                         SEQUENCE LISTING

<110>  Immunocore Limited
 
<120>  Specific binding molecules

<130>  P123152WO

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Leu Ser Pro Thr Val Trp Leu Ser Val 
1               5                   10  


<210>  2
<211>  197
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of the scaffold alpha chain extracellular 
       region

<400>  2

Ala Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg Asn Tyr Asn Thr 
                85                  90                  95      


Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr 
        195         


<210>  3
<211>  244
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of the scaffold beta chain extracellular 
       region

<400>  3

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  


Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ala 
                85                  90                  95      


Thr Gly Gly Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr 
            100                 105                 110         


Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
        115                 120                 125             


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro 
                165                 170                 175     


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu Ser Ser 
            180                 185                 190         


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg Asn His Phe 
        195                 200                 205             


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
    210                 215                 220                 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
225                 230                 235                 240 


Gly Arg Ala Asp 
                


<210>  4
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant alpha chain variable region (a01)

<400>  4

Ala Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Arg Asn Tyr Lys Thr 
                85                  90                  95      


Asp Leu Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro 
            100                 105                 110     


<210>  5
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant alpha chain variable region (a13)

<400>  5

Ala Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asp Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Arg Asn Tyr Lys Thr 
                85                  90                  95      


Asp Leu Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro 
            100                 105                 110     


<210>  6
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant alpha chain variable region (a19)

<400>  6

Ala Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Gly Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asp Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Arg Asn Tyr Lys Thr 
                85                  90                  95      


Asp Leu Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro 
            100                 105                 110     


<210>  7
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant beta chain variable region (b02)

<400>  7

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Leu Asn His Gly Tyr Met 
            20                  25                  30          


Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  


Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ala 
                85                  90                  95      


Thr Gly Gly Thr Gly Val Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr 
            100                 105                 110         


Val Leu 
        


<210>  8
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant beta chain variable region (b03)

<400>  8

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Ser His Gly Tyr Met 
            20                  25                  30          


Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  


Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ala 
                85                  90                  95      


Thr Gly Gly Thr Gly Asp Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr 
            100                 105                 110         


Val Leu 
        


<210>  9
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant beta chain variable region (b04)

<400>  9

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  


Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ala 
                85                  90                  95      


Thr Gly Gly Thr Gly Leu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr 
            100                 105                 110         


Val Leu 
        


<210>  10
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant beta chain variable region (b05)

<400>  10

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Leu Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  


Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ala 
                85                  90                  95      


Thr Gly Gly Thr Gly Asp Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr 
            100                 105                 110         


Val Leu 
        


<210>  11
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant beta chain variable region (b09)

<400>  11

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Leu Ser His Gly Tyr Met 
            20                  25                  30          


Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  


Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ala 
                85                  90                  95      


Thr Gly Gly Thr Gly Asp Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr 
            100                 105                 110         


Val Leu 
        


<210>  12
<211>  197
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain (a19)

<400>  12

Ala Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Gly Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asp Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Arg Asn Tyr Lys Thr 
                85                  90                  95      


Asp Leu Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr 
        195         


<210>  13
<211>  502
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain (b03)

<400>  13

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys 
            260                 265                 270         


Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Ser His Gly 
        275                 280                 285             


Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile 
    290                 295                 300                 


His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn 
305                 310                 315                 320 


Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu 
                325                 330                 335     


Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser 
            340                 345                 350         


Tyr Ala Thr Gly Gly Thr Gly Asp Leu Phe Phe Gly Glu Gly Ser Arg 
        355                 360                 365             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    370                 375                 380                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
385                 390                 395                 400 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                405                 410                 415     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            420                 425                 430         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu 
        435                 440                 445             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg Asn 
    450                 455                 460                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
465                 470                 475                 480 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                485                 490                 495     


Ala Trp Gly Arg Ala Asp 
            500         


<210>  14
<211>  197
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain (a13)

<400>  14

Ala Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asp Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Arg Asn Tyr Lys Thr 
                85                  90                  95      


Asp Leu Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr 
        195         


<210>  15
<211>  197
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain (a01)

<400>  15

Ala Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Arg Asn Tyr Lys Thr 
                85                  90                  95      


Asp Leu Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr 
        195         


<210>  16
<211>  502
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain (b09)

<400>  16

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys 
            260                 265                 270         


Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Leu Ser His Gly 
        275                 280                 285             


Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile 
    290                 295                 300                 


His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn 
305                 310                 315                 320 


Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu 
                325                 330                 335     


Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser 
            340                 345                 350         


Tyr Ala Thr Gly Gly Thr Gly Asp Leu Phe Phe Gly Glu Gly Ser Arg 
        355                 360                 365             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    370                 375                 380                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
385                 390                 395                 400 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                405                 410                 415     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            420                 425                 430         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu 
        435                 440                 445             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg Asn 
    450                 455                 460                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
465                 470                 475                 480 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                485                 490                 495     


Ala Trp Gly Arg Ala Asp 
            500         


<210>  17
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Leu Ser Pro Thr Val Trp Leu Ser Ala 
1               5                   10  


<210>  18
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR1

<400>  18

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR2

<400>  19

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  20
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR3

<400>  20

Cys Ala Val Arg Asn Tyr Asn Thr Asp Lys Leu Ile Phe 
1               5                   10              


<210>  21
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR1

<400>  21

Met Asn His Glu Tyr 
1               5   


<210>  22
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR2

<400>  22

Ser Val Gly Ala Gly Ile 
1               5       


<210>  23
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR3

<400>  23

Cys Ala Ser Ser Tyr Ala Thr Gly Gly Thr Gly Glu Leu Phe Phe 
1               5                   10                  15  


<210>  24
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR2

<400>  24

Ile Tyr Ser Asp Gly Asp 
1               5       


<210>  25
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR3

<400>  25

Cys Ala Ala Arg Asn Tyr Lys Thr Asp Leu Leu Ile Phe 
1               5                   10              


<210>  26
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR1

<400>  26

Leu Asn His Gly Tyr 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR1

<400>  27

Met Ser His Gly Tyr 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR1

<400>  28

Leu Ser His Gly Tyr 
1               5   


<210>  29
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR2

<400>  29

Ser Leu Gly Ala Gly Ile 
1               5       


<210>  30
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR3

<400>  30

Cys Ala Ser Ser Tyr Ala Thr Gly Gly Thr Gly Val Leu Phe Phe 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR3

<400>  31

Cys Ala Ser Ser Tyr Ala Thr Gly Gly Thr Gly Asp Leu Phe Phe 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR3

<400>  32

Cys Ala Ser Ser Tyr Ala Thr Gly Gly Thr Gly Leu Leu Phe Phe 
1               5                   10                  15  


<210>  33
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  33

Gly Gly Gly Gly Ser 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  34

Gly Gly Gly Ser Gly 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  35

Gly Gly Ser Gly Gly 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  36

Gly Ser Gly Gly Gly 
1               5   


<210>  37
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  37

Gly Ser Gly Gly Gly Pro 
1               5       


<210>  38
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  38

Gly Gly Glu Pro Ser 
1               5   


<210>  39
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  39

Gly Gly Glu Gly Gly Gly Pro 
1               5           


<210>  40
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  40

Gly Gly Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
1               5                   10          


<210>  41
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  41

Gly Gly Gly Ser Gly Gly Gly Gly 
1               5               


