               SEQUENCE LISTING

<110> GENETHON
      INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE
      MEDICALE)
      UNIVERSITE D'EVRY-VAL-D'ESSONNE

<120> PRODUCTION OF LARGE-SIZED QUASIDYSTROPHINS USING OVERLAPPING AAV VECTORS

<130> G143-B-53376 PCT

<150> EP19305377
<151> 2019-03-25

<160> 23

<170> BiSSAP 1.3.6

<210> 1
<211> 2361
<212> PRT
<213> Artificial Sequence


<220> 
<223> DD

<400> 1
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      
Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          
Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              
Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  
Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 
Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     
Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         
His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             
Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 
Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 
His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     
Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         
Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             
Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 
Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 
Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     
Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         
Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             
Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 
Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 
Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     
Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         
Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             
Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 
Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 
Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     
Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         
Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             
Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 
Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 
Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     
Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Glu Ile Ser Tyr Val 
            660                 665                 670         
Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu 
        675                 680                 685             
Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 
    690                 695                 700                 
Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser 
705                 710                 715                 720 
Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys Thr 
                725                 730                 735     
Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln Glu 
            740                 745                 750         
Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr 
        755                 760                 765             
Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg 
    770                 775                 780                 
Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu 
785                 790                 795                 800 
Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys 
                805                 810                 815     
Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln 
            820                 825                 830         
Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln 
        835                 840                 845             
Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu 
    850                 855                 860                 
Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys 
865                 870                 875                 880 
Arg Leu Glu Glu Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu 
                885                 890                 895     
Asn Glu Phe Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile 
            900                 905                 910         
Pro Leu Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln 
        915                 920                 925             
Val Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys 
    930                 935                 940                 
Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile Ser 
945                 950                 955                 960 
Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr Asn Leu 
                965                 970                 975     
Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln Gly Glu Ile 
            980                 985                 990         
Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys Lys Leu Glu Asp 
        995                 1000                1005            
Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp Leu Ser Pro Ile Arg 
    1010                1015                1020                
Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn Gln Glu Gly Pro Phe Asp 
1025                1030                1035                1040
Val Gln Glu Thr Glu Ile Ala Val Gln Ala Lys Gln Pro Asp Val Glu 
                1045                1050                1055    
Glu Ile Leu Ser Lys Gly Gln His Leu Tyr Lys Glu Lys Pro Ala Thr 
            1060                1065                1070        
Gln Pro Val Lys Arg Lys Leu Glu Asp Leu Ser Ser Glu Trp Lys Ala 
        1075                1080                1085            
Val Asn Arg Leu Leu Gln Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala 
    1090                1095                1100                
Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu 
1105                1110                1115                1120
Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu 
                1125                1130                1135    
Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn 
            1140                1145                1150        
Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val 
        1155                1160                1165            
Ile Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 
    1170                1175                1180                
Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg 
1185                1190                1195                1200
Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys 
                1205                1210                1215    
Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg 
            1220                1225                1230        
Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg 
        1235                1240                1245            
Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala 
    1250                1255                1260                
Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu 
1265                1270                1275                1280
Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile 
                1285                1290                1295    
Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn 
            1300                1305                1310        
Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser 
        1315                1320                1325            
Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile Asn Ala 
    1330                1335                1340                
Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu 
1345                1350                1355                1360
Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys 
                1365                1370                1375    
Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln 
            1380                1385                1390        
Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys 
        1395                1400                1405            
Glu Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 
    1410                1415                1420                
Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg 
1425                1430                1435                1440
Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp 
                1445                1450                1455    
Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile 
            1460                1465                1470        
Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu 
        1475                1480                1485            
Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu 
    1490                1495                1500                
Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln 
1505                1510                1515                1520
Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro 
                1525                1530                1535    
Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln 
            1540                1545                1550        
Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro 
        1555                1560                1565            
Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala 
    1570                1575                1580                
Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp 
1585                1590                1595                1600
Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln 
                1605                1610                1615    
Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile 
            1620                1625                1630        
Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln 
        1635                1640                1645            
Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 
    1650                1655                1660                
Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr 
1665                1670                1675                1680
Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu 
                1685                1690                1695    
Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg 
            1700                1705                1710        
Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe 
        1715                1720                1725            
Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn 
    1730                1735                1740                
Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp 
1745                1750                1755                1760
His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 
                1765                1770                1775    
Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 
            1780                1785                1790        
Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 
        1795                1800                1805            
Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 
    1810                1815                1820                
Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 
1825                1830                1835                1840
His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 
                1845                1850                1855    
Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 
            1860                1865                1870        
Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 
        1875                1880                1885            
Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 
    1890                1895                1900                
Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 
1905                1910                1915                1920
Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 
                1925                1930                1935    
Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 
            1940                1945                1950        
Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 
        1955                1960                1965            
Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 
    1970                1975                1980                
His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 
1985                1990                1995                2000
Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 
                2005                2010                2015    
Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 
            2020                2025                2030        
Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 
        2035                2040                2045            
Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 
    2050                2055                2060                
His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 
2065                2070                2075                2080
Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser 
                2085                2090                2095    
Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg 
            2100                2105                2110        
Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly 
        2115                2120                2125            
Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu 
    2130                2135                2140                
His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro 
2145                2150                2155                2160
Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser 
                2165                2170                2175    
Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu 
            2180                2185                2190        
Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu 
        2195                2200                2205            
His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr 
    2210                2215                2220                
Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu 
2225                2230                2235                2240
Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu 
                2245                2250                2255    
Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu 
            2260                2265                2270        
Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser 
        2275                2280                2285            
Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu 
    2290                2295                2300                
Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp 
2305                2310                2315                2320
Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met 
                2325                2330                2335    
Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro 
            2340                2345                2350        
Gly Lys Pro Met Arg Glu Asp Thr Met 
        2355                2360    

<210> 2
<211> 2427
<212> PRT
<213> Artificial Sequence


<220> 
<223> WL1

<400> 2
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      
Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          
Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              
Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  
Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 
Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     
Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         
His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             
Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 
Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 
His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     
Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         
Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             
Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 
Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 
Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     
Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         
Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             
Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 
Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 
Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     
Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         
Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             
Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 
Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 
Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     
Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         
Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             
Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 
Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 
Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     
Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         
Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             
Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 
Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Gly Leu Glu 
705                 710                 715                 720 
Lys Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 
                725                 730                 735     
Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys Thr 
            740                 745                 750         
Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala Lys Glu 
        755                 760                 765             
Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr Glu Ser Val 
    770                 775                 780                 
Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln Glu Ala Leu Lys 
785                 790                 795                 800 
Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln Trp Leu Cys Thr Arg 
                805                 810                 815     
Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu Val Trp Ala Cys Trp His 
            820                 825                 830         
Glu Leu Leu Ser Tyr Leu Glu Lys Ala Asn Lys Trp Leu Asn Glu Val 
        835                 840                 845             
Glu Phe Lys Leu Lys Thr Thr Glu Asn Ile Pro Gly Gly Ala Glu Glu 
    850                 855                 860                 
Ile Ser Glu Val Leu Asp Ser Leu Glu Asn Leu Met Arg His Ser Glu 
865                 870                 875                 880 
Asp Asn Pro Asn Gln Ile Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly 
                885                 890                 895     
Gly Val Met Asp Glu Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser 
            900                 905                 910         
Arg Trp Arg Glu Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu 
        915                 920                 925             
Glu Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu 
    930                 935                 940                 
Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu 
945                 950                 955                 960 
Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn 
                965                 970                 975     
Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu 
            980                 985                 990         
Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg 
        995                 1000                1005            
Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr 
    1010                1015                1020                
Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe 
1025                1030                1035                1040
Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe 
                1045                1050                1055    
Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile 
            1060                1065                1070        
Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln 
        1075                1080                1085            
Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu 
    1090                1095                1100                
Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 
1105                1110                1115                1120
Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser 
                1125                1130                1135    
Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val 
            1140                1145                1150        
Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Pro Asp 
        1155                1160                1165            
Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val 
    1170                1175                1180                
Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys 
1185                1190                1195                1200
Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp 
                1205                1210                1215    
Phe Asn Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp 
            1220                1225                1230        
Gln Val Ile Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile 
        1235                1240                1245            
Asn Glu Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln 
    1250                1255                1260                
Arg Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys 
1265                1270                1275                1280
Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile 
                1285                1290                1295    
Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn 
            1300                1305                1310        
Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln Trp Leu 
        1315                1320                1325            
Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys 
    1330                1335                1340                
Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys 
1345                1350                1355                1360
Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln 
                1365                1370                1375    
Thr Asn Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp 
            1380                1385                1390        
Tyr Ser Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile 
        1395                1400                1405            
Asn Ala Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu Ala 
    1410                1415                1420                
Ala Leu Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu 
1425                1430                1435                1440
Glu Lys Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val 
                1445                1450                1455    
Leu Gln Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly 
            1460                1465                1470        
Val Lys Glu Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu 
        1475                1480                1485            
Ala His Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile 
    1490                1495                1500                
Leu Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg 
1505                1510                1515                1520
Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu 
                1525                1530                1535    
Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu 
            1540                1545                1550        
His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp 
        1555                1560                1565            
Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln 
    1570                1575                1580                
Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys 
1585                1590                1595                1600
Glu Pro Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr 
                1605                1610                1615    
Glu Gln Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu 
            1620                1625                1630        
Leu Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys 
        1635                1640                1645            
Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser 
    1650                1655                1660                
Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu 
1665                1670                1675                1680
Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu 
                1685                1690                1695    
Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser 
            1700                1705                1710        
Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala 
        1715                1720                1725            
Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu 
    1730                1735                1740                
Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 
1745                1750                1755                1760
Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg 
                1765                1770                1775    
Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln 
            1780                1785                1790        
His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser 
        1795                1800                1805            
Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys 
    1810                1815                1820                
Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu 
1825                1830                1835                1840
Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg 
                1845                1850                1855    
Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys 
            1860                1865                1870        
Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp 
        1875                1880                1885            
Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu 
    1890                1895                1900                
Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys 
1905                1910                1915                1920
Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile 
                1925                1930                1935    
Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His 
            1940                1945                1950        
Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr 
        1955                1960                1965            
Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile 
    1970                1975                1980                
Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn 
1985                1990                1995                2000
Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro 
                2005                2010                2015    
Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln 
            2020                2025                2030        
Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr 
        2035                2040                2045            
Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile 
    2050                2055                2060                
Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln 
2065                2070                2075                2080
Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr 
                2085                2090                2095    
Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg 
            2100                2105                2110        
Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe 
        2115                2120                2125            
Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu 
    2130                2135                2140                
Gly Asp Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val 
2145                2150                2155                2160
Asp Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His 
                2165                2170                2175    
Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser 
            2180                2185                2190        
Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp 
        2195                2200                2205            
Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp 
    2210                2215                2220                
Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu 
2225                2230                2235                2240
Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu 
                2245                2250                2255    
Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln 
            2260                2265                2270        
His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met 
        2275                2280                2285            
Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala 
    2290                2295                2300                
Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile 
2305                2310                2315                2320
Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg 
                2325                2330                2335    
Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr 
            2340                2345                2350        
Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro 
        2355                2360                2365            
Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu 
    2370                2375                2380                
Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu 
2385                2390                2395                2400
Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn 
                2405                2410                2415    
Thr Pro Gly Lys Pro Met Arg Glu Asp Thr Met 
            2420                2425        

<210> 3
<211> 2406
<212> PRT
<213> Artificial Sequence


<220> 
<223> WL2

<400> 3
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      
Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          
Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              
Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  
Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 
Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     
Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         
His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             
Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 
Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 
His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     
Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         
Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             
Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 
Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 
Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     
Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         
Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             
Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 
Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 
Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     
Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         
Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             
Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 
Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 
Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     
Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         
Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             
Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 
Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 
Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     
Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         
Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             
Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 
Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Gly Leu Glu 
705                 710                 715                 720 
Lys Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 
                725                 730                 735     
Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys Thr 
            740                 745                 750         
Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala Lys Glu 
        755                 760                 765             
Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr Glu Ser Val 
    770                 775                 780                 
Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln Glu Ala Leu Lys 
785                 790                 795                 800 
Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln Trp Leu Cys Thr Arg 
                805                 810                 815     
Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu Val Trp Ala Cys Trp His 
            820                 825                 830         
Glu Leu Leu Ser Tyr Leu Glu Lys Ala Asn Lys Trp Leu Asn Glu Val 
        835                 840                 845             
Glu Phe Lys Leu Lys Thr Thr Glu Asn Ile Pro Gly Gly Ala Glu Glu 
    850                 855                 860                 
Ile Ser Glu Val Leu Asp Ser Leu Glu Asn Leu Met Arg His Ser Glu 
865                 870                 875                 880 
Asp Asn Pro Asn Gln Ile Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly 
                885                 890                 895     
Gly Val Met Asp Glu Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser 
            900                 905                 910         
Arg Trp Arg Glu Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu 
        915                 920                 925             
Glu Gln Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser Asp Ile Gln Lys 
    930                 935                 940                 
Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln Gly Val Asn Leu Lys 
945                 950                 955                 960 
Glu Glu Asp Phe Asn Lys Asp Met Asn Glu Asp Asn Glu Gly Thr Val 
                965                 970                 975     
Lys Glu Leu Leu Gln Arg Gly Asp Asn Leu Gln Gln Arg Ile Thr Asp 
            980                 985                 990         
Glu Arg Lys Arg Glu Glu Ile Lys Ile Lys Gln Gln Leu Leu Gln Thr 
        995                 1000                1005            
Lys His Asn Ala Phe Lys Asp Leu Arg Ser Gln Arg Arg Lys Lys Ala 
    1010                1015                1020                
Leu Glu Ile Ser His Gln Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp 
1025                1030                1035                1040
Leu Leu Lys Cys Leu Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro 
                1045                1050                1055    
Glu Pro Arg Asp Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln 
            1060                1065                1070        
Lys Lys Lys Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu 
        1075                1080                1085            
Ser Glu Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu 
    1090                1095                1100                
Ser Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 
1105                1110                1115                1120
Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val 
                1125                1130                1135    
Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr 
            1140                1145                1150        
Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln 
        1155                1160                1165            
Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe 
    1170                1175                1180                
Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser 
1185                1190                1195                1200
Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln 
                1205                1210                1215    
Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln 
            1220                1225                1230        
Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln 
        1235                1240                1245            
Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp 
    1250                1255                1260                
Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg 
1265                1270                1275                1280
Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr 
                1285                1290                1295    
Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg 
            1300                1305                1310        
Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr 
        1315                1320                1325            
Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp 
    1330                1335                1340                
Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu 
1345                1350                1355                1360
Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr 
                1365                1370                1375    
Gln Thr Val Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala 
            1380                1385                1390        
Ile Ser Lys Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Thr 
        1395                1400                1405            
His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala 
    1410                1415                1420                
Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr 
1425                1430                1435                1440
Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met 
                1445                1450                1455    
Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val 
            1460                1465                1470        
Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu 
        1475                1480                1485            
Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn 
    1490                1495                1500                
Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His 
1505                1510                1515                1520
Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln 
                1525                1530                1535    
Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln 
            1540                1545                1550        
Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val 
        1555                1560                1565            
His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met 
    1570                1575                1580                
Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu 
1585                1590                1595                1600
Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu 
                1605                1610                1615    
Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val 
            1620                1625                1630        
Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg 
        1635                1640                1645            
Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr 
    1650                1655                1660                
Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser 
1665                1670                1675                1680
Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu 
                1685                1690                1695    
Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn 
            1700                1705                1710        
Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile 
        1715                1720                1725            
Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg 
    1730                1735                1740                
Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His 
1745                1750                1755                1760
Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr 
                1765                1770                1775    
Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro 
            1780                1785                1790        
Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys 
        1795                1800                1805            
Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe 
    1810                1815                1820                
Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu 
1825                1830                1835                1840
Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln 
                1845                1850                1855    
His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile 
            1860                1865                1870        
Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn 
        1875                1880                1885            
Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu 
    1890                1895                1900                
Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser Phe 
1905                1910                1915                1920
Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp Lys Tyr 
                1925                1930                1935    
Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln 
            1940                1945                1950        
Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln 
        1955                1960                1965            
Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val 
    1970                1975                1980                
Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala 
1985                1990                1995                2000
Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu 
                2005                2010                2015    
Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala 
            2020                2025                2030        
Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe Arg Tyr Arg 
        2035                2040                2045            
Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser 
    2050                2055                2060                
Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met Val Glu Tyr 
2065                2070                2075                2080
Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val 
                2085                2090                2095    
Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg 
            2100                2105                2110        
Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu 
        2115                2120                2125            
Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala 
    2130                2135                2140                
Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu His 
2145                2150                2155                2160
Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr Leu 
                2165                2170                2175    
Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu Leu 
            2180                2185                2190        
Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln 
        2195                2200                2205            
Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg 
    2210                2215                2220                
Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn 
2225                2230                2235                2240
Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys Gly 
                2245                2250                2255    
Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro Gln 
            2260                2265                2270        
Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln 
        2275                2280                2285            
His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn 
    2290                2295                2300                
Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln 
2305                2310                2315                2320
Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser 
                2325                2330                2335    
Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val 
            2340                2345                2350        
Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu Ser 
        2355                2360                2365            
Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu 
    2370                2375                2380                
Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys Pro 
2385                2390                2395                2400
Met Arg Glu Asp Thr Met 
                2405    

<210> 4
<211> 7284
<212> DNA
<213> Artificial Sequence


<220> 
<223> WL1 wt

<400> 4
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaaatgt tgccaaggcc acctaaagtg      780

actaaagaag aacattttca gttacatcat caaatgcact attctcaaca gatcacggtc      840

agtctagcac agggatatga gagaacttct tcccctaagc ctcgattcaa gagctatgcc      900

tacacacagg ctgcttatgt caccacctct gaccctacac ggagcccatt tccttcacag      960

catttggaag ctcctgaaga caagtcattt ggcagttcat tgatggagag tgaagtaaac     1020

ctggaccgtt atcaaacagc tttagaagaa gtattatcgt ggcttctttc tgctgaggac     1080

acattgcaag cacaaggaga gatttctaat gatgtggaag tggtgaaaga ccagtttcat     1140

actcatgagg ggtacatgat ggatttgaca gcccatcagg gccgggttgg taatattcta     1200

caattgggaa gtaagctgat tggaacagga aaattatcag aagatgaaga aactgaagta     1260

caagagcaga tgaatctcct aaattcaaga tgggaatgcc tcagggtagc tagcatggaa     1320

aaacaaagca atttacatag agttttaatg gatctccaga atcagaaact gaaagagttg     1380

aatgactggc taacaaaaac agaagaaaga acaaggaaaa tggaggaaga gcctcttgga     1440

cctgatcttg aagacctaaa acgccaagta caacaacata aggtgcttca agaagatcta     1500

gaacaagaac aagtcagggt caattctctc actcacatgg tggtggtagt tgatgaatct     1560

agtggagatc acgcaactgc tgctttggaa gaacaactta aggtattggg agatcgatgg     1620

gcaaacatct gtagatggac agaagaccgc tgggttcttt tacaagacat ccttctcaaa     1680

tggcaacgtc ttactgaaga acagtgcctt tttagtgcat ggctttcaga aaaagaagat     1740

gcagtgaaca agattcacac aactggcttt aaagatcaaa atgaaatgtt atcaagtctt     1800

caaaaactgg ccgttttaaa agcggatcta gaaaagaaaa agcaatccat gggcaaactg     1860

tattcactca aacaagatct tctttcaaca ctgaagaata agtcagtgac ccagaagacg     1920

gaagcatggc tggataactt tgcccggtgt tgggataatt tagtccaaaa acttgaaaag     1980

agtacagcac agatttcaca ggctgtcacc accactcagc catcactaac acagacaact     2040

gtaatggaaa cagtaactac ggtgaccaca agggaacaga tcctggtaaa gcatgctcaa     2100

gaggaacttc caccaccacc tccccaaaag aagaggcaga ttactgtgga tggtttggag     2160

aaaactgtaa gcctccagaa agatctatca gagatgcacg aatggatgac acaagctgaa     2220

gaagagtatc ttgagagaga ttttgaatat aaaactccag atgaattaca gaaagcagtt     2280

gaagagatga agagagctaa agaagaggcc caacaaaaag aagcgaaagt gaaactcctt     2340

actgagtctg taaatagtgt catagctcaa gctccacctg tagcacaaga ggccttaaaa     2400

aaggaacttg aaactctaac caccaactac cagtggctct gcactaggct gaatgggaaa     2460

tgcaagactt tggaagaagt ttgggcatgt tggcatgagt tattgtcata cttggagaaa     2520

gcaaacaagt ggctaaatga agtagaattt aaacttaaaa ccactgaaaa cattcctggc     2580

ggagctgagg aaatctctga ggtgctagat tcacttgaaa atttgatgcg acattcagag     2640

gataacccaa atcagattcg catattggca cagaccctaa cagatggcgg agtcatggat     2700

gagctaatca atgaggaact tgagacattt aattctcgtt ggagggaact acatgaagag     2760

gctgtaagga ggcaaaagtt gcttgaacag attcacactg tccgtgaaga aacgatgatg     2820

gtgatgactg aagacatgcc tttggaaatt tcttatgtgc cttctactta tttgactgaa     2880

atcactcatg tctcacaagc cctattagaa gtggaacaac ttctcaatgc tcctgacctc     2940

tgtgctaagg actttgaaga tctctttaag caagaggagt ctctgaagaa tataaaagat     3000

agtctacaac aaagctcagg tcggattgac attattcata gcaagaagac agcagcattg     3060

caaagtgcaa cgcctgtgga aagggtgaag ctacaggaag ctctctccca gcttgatttc     3120

caatgggaaa aagttaacaa aatgtacaag gaccgacaag ggcgatttga cagatctgtt     3180

gagaaatggc ggcgttttca ttatgatata aagatattta atcagtggct aacagaagct     3240

gaacagtttc tcagaaagac acaaattcct gagaattggg aacatgctaa atacaaatgg     3300

tatcttaagg aactccagga tggcattggg cagcggcaaa ctgttgtcag aacattgaat     3360

gcaactgggg aagaaataat tcagcaatcc tcaaaaacag atgccagtat tctacaggaa     3420

aaattgggaa gcctgaatct gcggtggcag gaggtctgca aacagctgtc agacagaaaa     3480

aagaggctag aagagcagcc tgacctagct cctggactga ccactattgg agcctctcct     3540

actcagactg ttactctggt gacacaacct gtggttacta aggaaactgc catctccaaa     3600

ctagaaatgc catcttcctt gatgttggag gtacctgctc tggcagattt caaccgggct     3660

tggacagaac ttaccgactg gctttctctg cttgatcaag ttataaaatc acagagggtg     3720

atggtgggtg accttgagga tatcaacgag atgatcatca agcagaaggc aacaatgcag     3780

gatttggaac agaggcgtcc ccagttggaa gaactcatta ccgctgccca aaatttgaaa     3840

aacaagacca gcaatcaaga ggctagaaca atcattacgg atcgaattga aagaattcag     3900

aatcagtggg atgaagtaca agaacacctt cagaaccgga ggcaacagtt gaatgaaatg     3960

ttaaaggatt caacacaatg gctggaagct aaggaagaag ctgagcaggt cttaggacag     4020

gccagagcca agcttgagtc atggaaggag ggtccctata cagtagatgc aatccaaaag     4080

aaaatcacag aaaccaagca gttggccaaa gacctccgcc agtggcagac aaatgtagat     4140

gtggcaaatg acttggccct gaaacttctc cgggattatt ctgcagatga taccagaaaa     4200

gtccacatga taacagagaa tatcaatgcc tcttggagaa gcattcataa aagggtgagt     4260

gagcgagagg ctgctttgga agaaactcat agattactgc aacagttccc cctggacctg     4320

gaaaagtttc ttgcctggct tacagaagct gaaacaactg ccaatgtcct acaggatgct     4380

acccgtaagg aaaggctcct agaagactcc aagggagtaa aagagctgat gaaacaatgg     4440

caagacctcc aaggtgaaat tgaagctcac acagatgttt atcacaacct ggatgaaaac     4500

agccaaaaaa tcctgagatc cctggaaggt tccgatgatg cagtcctgtt acaaagacgt     4560

ttggataaca tgaacttcaa gtggagtgaa cttcggaaaa agtctctcaa cattaggtcc     4620

catttggaag ccagttctga ccagtggaag cgtctgcacc tttctctgca ggaacttctg     4680

gtgtggctac agctgaaaga tgatgaatta agccggcagg cacctattgg aggcgacttt     4740

ccagcagttc agaagcagaa cgatgtacat agggccttca agagggaatt gaaaactaaa     4800

gaacctgtaa tcatgagtac tcttgagact gtacgaatat ttctgacaga gcagcctttg     4860

gaaggactag agaaactcta ccaggagccc agagagctgc ctcctgagga gagagcccag     4920

aatgtcactc ggcttctacg aaagcaggct gaggaggtca atactgagtg ggaaaaattg     4980

aacctgcact ccgctgactg gcagagaaaa atagatgaga cccttgaaag actccaggaa     5040

cttcaagagg ccacggatga gctggacctc aagctgcgcc aagctgaggt gatcaaggga     5100

tcctggcagc ccgtgggcga tctcctcatt gactctctcc aagatcacct cgagaaagtc     5160

aaggcacttc gaggagaaat tgcgcctctg aaagagaacg tgagccacgt caatgacctt     5220

gctcgccagc ttaccacttt gggcattcag ctctcaccgt ataacctcag cactctggaa     5280

gacctgaaca ccagatggaa gcttctgcag gtggccgtcg aggaccgagt caggcagctg     5340

catgaagccc acagggactt tggtccagca tctcagcact ttctttccac gtctgtccag     5400

ggtccctggg agagagccat ctcgccaaac aaagtgccct actatatcaa ccacgagact     5460

caaacaactt gctgggacca tcccaaaatg acagagctct accagtcttt agctgacctg     5520

aataatgtca gattctcagc ttataggact gccatgaaac tccgaagact gcagaaggcc     5580

ctttgcttgg atctcttgag cctgtcagct gcatgtgatg ccttggacca gcacaacctc     5640

aagcaaaatg accagcccat ggatatcctg cagattatta attgtttgac cactatttat     5700

gaccgcctgg agcaagagca caacaatttg gtcaacgtcc ctctctgcgt ggatatgtgt     5760

ctgaactggc tgctgaatgt ttatgatacg ggacgaacag ggaggatccg tgtcctgtct     5820

tttaaaactg gcatcatttc cctgtgtaaa gcacatttgg aagacaagta cagatacctt     5880

ttcaagcaag tggcaagttc aacaggattt tgtgaccagc gcaggctggg cctccttctg     5940

catgattcta tccaaattcc aagacagttg ggtgaagttg catcctttgg gggcagtaac     6000

attgagccaa gtgtccggag ctgcttccaa tttgctaata ataagccaga gatcgaagcg     6060

gccctcttcc tagactggat gagactggaa ccccagtcca tggtgtggct gcccgtcctg     6120

cacagagtgg ctgctgcaga aactgccaag catcaggcca aatgtaacat ctgcaaagag     6180

tgtccaatca ttggattcag gtacaggagt ctaaagcact ttaattatga catctgccaa     6240

agctgctttt tttctggtcg agttgcaaaa ggccataaaa tgcactatcc catggtggaa     6300

tattgcactc cgactacatc aggagaagat gttcgagact ttgccaaggt actaaaaaac     6360

aaatttcgaa ccaaaaggta ttttgcgaag catccccgaa tgggctacct gccagtgcag     6420

actgtcttag agggggacaa catggaaact cccgttactc tgatcaactt ctggccagta     6480

gattctgcgc ctgcctcgtc ccctcagctt tcacacgatg atactcattc acgcattgaa     6540

cattatgcta gcaggctagc agaaatggaa aacagcaatg gatcttatct aaatgatagc     6600

atctctccta atgagagcat agatgatgaa catttgttaa tccagcatta ctgccaaagt     6660

ttgaaccagg actcccccct gagccagcct cgtagtcctg cccagatctt gatttcctta     6720

gagagtgagg aaagagggga gctagagaga atcctagcag atcttgagga agaaaacagg     6780

aatctgcaag cagaatatga ccgtctaaag cagcagcacg aacataaagg cctgtcccca     6840

ctgccgtccc ctcctgaaat gatgcccacc tctccccaga gtccccggga tgctgagctc     6900

attgctgagg ccaagctact gcgtcaacac aaaggccgcc tggaagccag gatgcaaatc     6960

ctggaagacc acaataaaca gctggagtca cagttacaca ggctaaggca gctgctggag     7020

caaccccagg cagaggccaa agtgaatggc acaacggtgt cctctccttc tacctctcta     7080

cagaggtccg acagcagtca gcctatgctg ctccgagtgg ttggcagtca aacttcggac     7140

tccatgggtg aggaagatct tctcagtcct ccccaggaca caagcacagg gttagaggag     7200

gtgatggagc aactcaacaa ctccttccct agttcaagag gaagaaatac ccctggaaag     7260

ccaatgagag aggacacaat gtag                                            7284


<210> 5
<211> 7284
<212> DNA
<213> Artificial Sequence


<220> 
<223> WL1 opt

<400> 5
atgctgtggt gggaggaggt ggaggactgc tatgagagag aggatgtgca gaagaagacc       60

ttcaccaagt gggtgaatgc ccagttcagc aagtttggca agcagcacat tgagaacctg      120

ttctctgacc tgcaggatgg caggagcctg ctggacctgc tggagggcct aacaggccag      180

aagctgccca aggagaaggg cagtaccagg gtgcatgccc tgaacaatgt gaacaaggcc      240

ctgagggtgc tgcagaacaa caatgtggac ctagtgaata ttggcagtac agatattgtg      300

gatggcaacc acaagctgac cctgggcctg atctggaata ttatcctaca ctggcaggtg      360

aagaatgtga tgaagaatat tatggctggc ctgcagcaga ccaactctga gaagatcctg      420

ctgagctggg tgaggcagag taccaggaac tacccccagg tgaatgtgat caacttcacc      480

accagctggt ctgatggcct ggccctgaat gccctaatcc acagccacag gcctgacctg      540

tttgactgga actctgtggt gtgccagcag tctgccaccc agaggctaga gcatgccttc      600

aatattgcca ggtaccagct ggggattgag aagctgctgg accctgagga tgtggataca      660

acctaccctg acaagaagag catcctgatg tacatcacca gcctgttcca ggtgctgccc      720

cagcaggtga gcattgaggc catccaggag gtggagatgc tacccaggcc ccccaaggtg      780

accaaggagg agcacttcca gctacaccac cagatgcact acagccagca gatcacagtg      840

agcctggccc agggctatga gaggaccagc agccccaagc ccaggttcaa gagctatgcc      900

tacacccagg ctgcctatgt gaccacctca gaccccacca ggagcccctt ccccagccag      960

cacctggagg cccctgagga caagagcttt ggcagcagcc tgatggagtc tgaggtgaac     1020

ctggacaggt accagacagc cctggaggag gtgctgagct ggctgctgtc tgctgaggat     1080

accctacagg cccagggaga gatcagcaat gatgtggagg tggtgaagga ccagttccat     1140

acccatgagg gctacatgat ggacctaaca gcccaccagg gcagggtggg caacatcctg     1200

cagctgggca gcaagctgat tggcacaggc aagctgtctg aggatgagga gacagaggtg     1260

caggagcaga tgaacctgct gaacagcagg tgggagtgcc tgagggtggc cagtatggag     1320

aagcagagca acctacacag ggtgctgatg gacctgcaga accagaagct gaaggagctg     1380

aatgactggc tgaccaagac agaggagagg accaggaaga tggaggagga gcccctgggc     1440

cctgacctgg aggacctaaa gaggcaggtg cagcagcaca aggtgctgca ggaggacctg     1500

gagcaggagc aggtgagggt gaacagccta acccatatgg tggtggtggt ggatgagagc     1560

tcaggagacc atgctacagc tgccctggag gagcagctga aggtgctggg agacaggtgg     1620

gctaatatct gcaggtggac agaggacagg tgggtgctgc tgcaggatat cctgctgaag     1680

tggcagaggc tgacagagga gcagtgcctg ttctctgcct ggctgtcaga gaaggaggat     1740

gctgtgaaca agatccatac aacaggcttc aaggaccaga atgagatgct gagcagcctg     1800

cagaagctgg ctgtgctgaa ggctgacctg gagaagaaga agcagagtat gggcaagctg     1860

tacagcctga agcaggacct gctgagtacc ctgaagaaca agtctgtgac ccagaagaca     1920

gaggcctggc tggacaactt tgccaggtgc tgggataacc tggtgcagaa gctggagaag     1980

agtacagccc agatcagcca ggctgtgaca acaacccagc ccagcctgac ccagacaaca     2040

gtgatggaga cagtgacaac agtgacaacc agggagcaga tcctagtgaa gcatgcccag     2100

gaggagctgc cccccccccc cccccagaag aagaggcaga ttacagtgga tggcctggag     2160

aagacagtga gcctccagaa ggacctgtca gagatgcatg agtggatgac ccaggctgag     2220

gaggagtacc tggagaggga ctctgagtac aagacccctg atgagctgca gaaggctgtg     2280

gaggagatga agagggccaa ggaggaggcc cagcagaagg aggccaaggt gaagctgctg     2340

acagagtctg tgaactctgt gattgcccag gccccccctg tggcccagga ggccctgaag     2400

aaggagctgg agaccctgac aaccaactac cagtggctgt gcaccaggct gaatggcaag     2460

tgcaagaccc tagaggaggt gtgggcctgc tggcatgagc tgctgagcta cctggagaag     2520

gccaacaagt ggctgaatga ggtggagttc aagctgaaga ccacagagaa catccctgga     2580

ggagctgagg agatctctga ggtgctggac agcctggaga acctaatgag gcactctgag     2640

gacaacccca accagatcag gatcctggcc cagaccctga cagatggagg agtgatggat     2700

gagctgatca atgaggagct ggagaccttc aacagcaggt ggagggagct acatgaggag     2760

gctgtgagga ggcagaagct gctagagcag atccatacag tgagggagga gacaatgatg     2820

gtgatgacag aggatatgcc cctggagatc agctatgtgc ccagcaccta cctaacagag     2880

atcacccatg tgagccaggc cctgctggag gtggagcagc tgctgaatgc ccctgacctg     2940

tgtgccaagg actttgagga cctgttcaag caggaggaga gcctgaagaa catcaaggac     3000

agcctgcagc agagctcagg caggattgat attatccaca gcaagaagac agctgccctg     3060

cagtctgcta cccctgtgga gagggtgaag ctgcaggagg ccctgagcca gctggacttc     3120

cagtgggaga aggtgaacaa gatgtacaag gacaggcagg gcaggtttga caggtcagtg     3180

gagaagtgga ggaggttcca ctatgacatc aagatcttca accagtggct gacagaggct     3240

gagcagttcc taaggaagac ccagatccct gagaactggg agcatgccaa gtacaagtgg     3300

taccttaagg agctgcagga tggcattggc cagaggcaga cagtggtgag gaccctgaat     3360

gctacagggg aggagattat ccagcagagc agcaagacag atgccagtat cctgcaggag     3420

aagctgggca gcctgaacct gaggtggcag gaggtgtgca agcagctgtc tgacaggaag     3480

aagaggctgg aggagcagcc tgacctggcc cctggcctga caacaattgg agccagccct     3540

acccagacag tgaccctggt gacccagcct gtggtgacca aggagacagc tatcagcaag     3600

ctggagatgc ccagcagcct gatgctggag gtgcctgccc tggctgactt caacagggcc     3660

tggacagagc tgacagactg gctgagcctg ctggaccagg tgatcaagag ccagagggtg     3720

atggtggggg acctggagga tatcaatgag atgattatca agcagaaggc tacaatgcag     3780

gacctggagc agaggaggcc ccagctggag gagctgatta cagctgccca gaacctaaag     3840

aacaagacca gcaaccagga ggccaggaca attattacag acaggattga gaggatccag     3900

aaccagtggg atgaggtgca ggagcacctg cagaacagga ggcagcagct gaatgagatg     3960

ctgaaggaca gtacccagtg gctggaggcc aaggaggagg ctgagcaggt gctgggccag     4020

gccagggcca agctggagag ctggaaggag ggcccctaca cagtggatgc catccagaag     4080

aagatcacag agaccaagca gctggccaag gacctgaggc agtggcagac caatgtggat     4140

gtggccaatg acctggccct gaagctgctg agggactact cagctgatga caccaggaag     4200

gtgcacatga tcacagagaa catcaatgcc agctggagga gcatccacaa gagggtgtct     4260

gagagggagg ctgccctaga ggagacccac aggctgctgc agcagttccc cctggacctg     4320

gagaagttcc tggcctggct gacagaggct gagacaacag ccaatgtgct gcaggatgct     4380

accaggaagg agaggctgct ggaggacagc aagggagtga aggagctgat gaagcagtgg     4440

caggacctac agggggagat tgaggcccat acagatgtgt accacaacct ggatgagaac     4500

agccagaaga tcctgaggag cctggagggc tctgatgatg ctgtgctgct gcagaggagg     4560

ctggacaata tgaacttcaa gtggtctgag ctgaggaaga agagcctaaa tatcaggagc     4620

cacctggagg ccagctctga ccagtggaag aggctacacc tgagcctgca ggagctgctg     4680

gtgtggctgc agctgaagga tgatgagcta agcaggcagg cccctattgg gggagacttc     4740

cctgctgtgc agaagcagaa tgatgtgcac agggccttca agagggagct gaagaccaag     4800

gagcctgtga ttatgagtac cctggagaca gtgaggatct tcctgacaga gcagcccctg     4860

gagggcctgg agaagctgta ccaggagccc agggagctgc cccctgagga gagggcccag     4920

aatgtgacca ggctgctgag gaagcaggct gaggaggtga atacagagtg ggagaagctg     4980

aacctacact ctgctgactg gcagaggaag attgatgaga ccctggagag gctgcaggag     5040

ctgcaggagg ctacagatga gctggacctg aagctgaggc aggctgaggt gatcaagggc     5100

agctggcagc ctgtggggga cctgctgatt gacagcctac aggaccacct ggagaaggtg     5160

aaggccctga ggggagagat tgccccccta aaggagaatg tgagtcatgt gaatgacctg     5220

gccaggcagc tgaccaccct gggcatccag ctgagcccct acaacctgag caccctggag     5280

gacctgaaca ccaggtggaa gctgctgcag gtggctgtgg aggacagggt gaggcagcta     5340

catgaggccc acagggactt tggccctgcc agccagcact tcctaagcac ctctgttcag     5400

ggcccctggg agagggccat cagccccaac aaggtgccct actacatcaa ccatgagacc     5460

cagaccacct gctgggacca ccccaagatg acagagctgt accagagcct ggctgacctg     5520

aacaatgtga ggttctctgc ctacaggaca gccatgaagc tgaggaggct gcagaaggcc     5580

ctgtgcctgg acctgctgag cctgtctgct gcctgtgatg ccctagacca gcacaacctg     5640

aagcagaatg accagcccat ggacatcctt cagatcatca actgcctgac caccatctat     5700

gacaggctag agcaggagca caacaacctg gtgaatgtgc ccctgtgtgt ggacatgtgc     5760

ctgaactggc tgctgaatgt gtatgacaca ggcaggacag gcaggatcag ggtgctgagc     5820

ttcaagacag gcatcatcag cctatgcaag gctcacctgg aggacaagta caggtacctg     5880

ttcaagcagg tggccagcag cacaggcttc tgtgaccaga ggaggctggg cctgctactt     5940

catgacagca ttcagatccc caggcagctg ggagaggtgg ccagctttgg aggcagcaac     6000

attgagccct cagtgaggag ctgcttccag tttgccaaca acaagcctga gattgaggct     6060

gccctgttcc tggactggat gaggctggag cctcagagca tggtgtggct gcctgtgctg     6120

cacagggtgg ctgctgctga gacagccaag catcaggcca agtgcaacat ctgcaaggag     6180

tgccccatca ttggcttcag gtacaggagc ctaaagcact tcaactatga catctgccag     6240

agctgcttct tctcaggcag ggtggccaag ggccacaaga tgcactaccc catggtggag     6300

tactgcaccc ccaccacctc aggagaggat gtgagggact ttgccaaggt gctgaagaac     6360

aagttcagga ccaagaggta ctttgccaag caccccagga tgggctacct gcctgtgcag     6420

acagtgctgg agggggacaa catggagacc cctgtgaccc tgatcaactt ctggcctgtg     6480

gactcagccc ctgccagcag cccccagctg agccatgatg acacccacag caggattgag     6540

cactatgcca gcaggctggc tgagatggag aacagcaatg gcagctacct aaatgacagc     6600

atcagcccca atgagagcat tgatgatgag cacctgctaa tccagcacta ctgccagagc     6660

ctgaaccagg acagccccct gagccagccc aggagccctg cccagatcct gatcagcctg     6720

gagtctgagg agagggggga gctggagagg atcctggctg acctggagga ggagaacagg     6780

aaccttcagg ctgagtatga caggctaaag cagcagcatg agcacaaggg cctgagcccc     6840

ctacccagcc cccctgagat gatgcccacc agcccccaga gccccaggga tgctgagctg     6900

attgctgagg ccaagctgct gaggcagcac aagggcaggc tggaggccag gatgcagatc     6960

ctagaggacc acaacaagca gctggagagc cagctacaca ggctgaggca gctgctggag     7020

cagcctcagg ctgaggccaa ggtgaatggc accacagtga gcagccccag caccagcctg     7080

cagaggtctg acagcagtca gcccatgctg ctcagggtgg tgggcagtca gacctctgac     7140

agcatgggag aggaggacct gctgagcccc cctcaggaca ccagcacagg cctggaggag     7200

gtgatggagc agctgaacaa cagcttcccc agcagcaggg gcaggaacac ccctggcaag     7260

cccatgaggg aggacaccat gtag                                            7284


<210> 6
<211> 4768
<212> DNA
<213> Artificial Sequence


<220> 
<223> 5' WL1 opt

<400> 6
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta ttggccgtcc      180

gccctcggca ccatcctcac gacacccaaa tatggcgacg ggtgaggaat ggtggggagt      240

tatttttaga gcggtgagga aggtgggcag gcagcaggtg ttggcgctct aaaaataact      300

cccgggagtt atttttagag cggaggaatg gtggacaccc aaatatggcg acggttcctc      360

acccgtcgcc atatttgggt gtccgccctc ggccggggcc gcattcctgg gggccgggcg      420

gtgctcccgc ccgcctcgat aaaaggctcc ggggccggcg gcggcccacg agctacccgg      480

aggagcggga ggcgccaagc tctagagtaa gtatcaaggt tacaagacag gtttaaggag      540

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta      600

ttggtcttac tgacatccac tttgcctttc tctccacagg ccaccatgct gtggtgggag      660

gaggtggagg actgctatga gagagaggat gtgcagaaga agaccttcac caagtgggtg      720

aatgcccagt tcagcaagtt tggcaagcag cacattgaga acctgttctc tgacctgcag      780

gatggcagga gcctgctgga cctgctggag ggcctaacag gccagaagct gcccaaggag      840

aagggcagta ccagggtgca tgccctgaac aatgtgaaca aggccctgag ggtgctgcag      900

aacaacaatg tggacctagt gaatattggc agtacagata ttgtggatgg caaccacaag      960

ctgaccctgg gcctgatctg gaatattatc ctacactggc aggtgaagaa tgtgatgaag     1020

aatattatgg ctggcctgca gcagaccaac tctgagaaga tcctgctgag ctgggtgagg     1080

cagagtacca ggaactaccc ccaggtgaat gtgatcaact tcaccaccag ctggtctgat     1140

ggcctggccc tgaatgccct aatccacagc cacaggcctg acctgtttga ctggaactct     1200

gtggtgtgcc agcagtctgc cacccagagg ctagagcatg ccttcaatat tgccaggtac     1260

cagctgggga ttgagaagct gctggaccct gaggatgtgg atacaaccta ccctgacaag     1320

aagagcatcc tgatgtacat caccagcctg ttccaggtgc tgccccagca ggtgagcatt     1380

gaggccatcc aggaggtgga gatgctaccc aggcccccca aggtgaccaa ggaggagcac     1440

ttccagctac accaccagat gcactacagc cagcagatca cagtgagcct ggcccagggc     1500

tatgagagga ccagcagccc caagcccagg ttcaagagct atgcctacac ccaggctgcc     1560

tatgtgacca cctcagaccc caccaggagc cccttcccca gccagcacct ggaggcccct     1620

gaggacaaga gctttggcag cagcctgatg gagtctgagg tgaacctgga caggtaccag     1680

acagccctgg aggaggtgct gagctggctg ctgtctgctg aggataccct acaggcccag     1740

ggagagatca gcaatgatgt ggaggtggtg aaggaccagt tccataccca tgagggctac     1800

atgatggacc taacagccca ccagggcagg gtgggcaaca tcctgcagct gggcagcaag     1860

ctgattggca caggcaagct gtctgaggat gaggagacag aggtgcagga gcagatgaac     1920

ctgctgaaca gcaggtggga gtgcctgagg gtggccagta tggagaagca gagcaaccta     1980

cacagggtgc tgatggacct gcagaaccag aagctgaagg agctgaatga ctggctgacc     2040

aagacagagg agaggaccag gaagatggag gaggagcccc tgggccctga cctggaggac     2100

ctaaagaggc aggtgcagca gcacaaggtg ctgcaggagg acctggagca ggagcaggtg     2160

agggtgaaca gcctaaccca tatggtggtg gtggtggatg agagctcagg agaccatgct     2220

acagctgccc tggaggagca gctgaaggtg ctgggagaca ggtgggctaa tatctgcagg     2280

tggacagagg acaggtgggt gctgctgcag gatatcctgc tgaagtggca gaggctgaca     2340

gaggagcagt gcctgttctc tgcctggctg tcagagaagg aggatgctgt gaacaagatc     2400

catacaacag gcttcaagga ccagaatgag atgctgagca gcctgcagaa gctggctgtg     2460

ctgaaggctg acctggagaa gaagaagcag agtatgggca agctgtacag cctgaagcag     2520

gacctgctga gtaccctgaa gaacaagtct gtgacccaga agacagaggc ctggctggac     2580

aactttgcca ggtgctggga taacctggtg cagaagctgg agaagagtac agcccagatc     2640

agccaggctg tgacaacaac ccagcccagc ctgacccaga caacagtgat ggagacagtg     2700

acaacagtga caaccaggga gcagatccta gtgaagcatg cccaggagga gctgcccccc     2760

cccccccccc agaagaagag gcagattaca gtggatggcc tggagaagac agtgagcctc     2820

cagaaggacc tgtcagagat gcatgagtgg atgacccagg ctgaggagga gtacctggag     2880

agggactctg agtacaagac ccctgatgag ctgcagaagg ctgtggagga gatgaagagg     2940

gccaaggagg aggcccagca gaaggaggcc aaggtgaagc tgctgacaga gtctgtgaac     3000

tctgtgattg cccaggcccc ccctgtggcc caggaggccc tgaagaagga gctggagacc     3060

ctgacaacca actaccagtg gctgtgcacc aggctgaatg gcaagtgcaa gaccctagag     3120

gaggtgtggg cctgctggca tgagctgctg agctacctgg agaaggccaa caagtggctg     3180

aatgaggtgg agttcaagct gaagaccaca gagaacatcc ctggaggagc tgaggagatc     3240

tctgaggtgc tggacagcct ggagaaccta atgaggcact ctgaggacaa ccccaaccag     3300

atcaggatcc tggcccagac cctgacagat ggaggagtga tggatgagct gatcaatgag     3360

gagctggaga ccttcaacag caggtggagg gagctacatg aggaggctgt gaggaggcag     3420

aagctgctag agcagatcca tacagtgagg gaggagacaa tgatggtgat gacagaggat     3480

atgcccctgg agatcagcta tgtgcccagc acctacctaa cagagatcac ccatgtgagc     3540

caggccctgc tggaggtgga gcagctgctg aatgcccctg acctgtgtgc caaggacttt     3600

gaggacctgt tcaagcagga ggagagcctg aagaacatca aggacagcct gcagcagagc     3660

tcaggcagga ttgatattat ccacagcaag aagacagctg ccctgcagtc tgctacccct     3720

gtggagaggg tgaagctgca ggaggccctg agccagctgg acttccagtg ggagaaggtt     3780

aacaagatgt acaaggacag gcagggcagg tttgacaggt cagtggagaa gtggaggagg     3840

ttccactatg acatcaagat cttcaaccag tggctgacag aggctgagca gttcctaagg     3900

aagacccaga tccctgagaa ctgggagcat gccaagtaca agtggtacct taaggagctg     3960

caggatggca ttggccagag gcagacagtg gtgaggaccc tgaatgctac aggggaggag     4020

attatccagc agagcagcaa gacagatgcc agtatcctgc aggagaagct gggcagcctg     4080

aacctgaggt ggcaggaggt gtgcaagcag ctgtctgaca ggaagaagag gctggaggag     4140

cagcctgacc tggcccctgg cctgacaaca attggagcca gccctaccca gacagtgacc     4200

ctggtgaccc agcctgtggt gaccaaggag acagctatca gcaagctgga gatgcccagc     4260

agcctgatgc tggaggtgcc tgccctggct gacttcaaca gggcctggac agagctgaca     4320

gactggctga gcctgctgga ccaggtgatc aagagccaga gggtgatggt gggggacctg     4380

gaggatatca atgagatgat tatcaagcag aaggctacaa tgcaggacct ggagcagagg     4440

aggccccagc tggaggagct gattacagct gcccagaacc taaagaacaa gaccagcaac     4500

caggaggcca ggacaattat tacagacagg attgagagga tccagaacca gtgggatgag     4560

gtgcaggagc acctgcagtt tacgcgtttt gcggccgctt tacgtagata agtagcatgg     4620

cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg     4680

cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg     4740

ggcggcctca gtgagcgagc gagcgcgc                                        4768


<210> 7
<211> 4715
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3' WL1 opt

<400> 7
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta tttgaacaag      180

atgtacaagg acaggcaggg caggtttgac aggtcagtgg agaagtggag gaggttccac      240

tatgacatca agatcttcaa ccagtggctg acagaggctg agcagttcct aaggaagacc      300

cagatccctg agaactggga gcatgccaag tacaagtggt accttaagga gctgcaggat      360

ggcattggcc agaggcagac agtggtgagg accctgaatg ctacagggga ggagattatc      420

cagcagagca gcaagacaga tgccagtatc ctgcaggaga agctgggcag cctgaacctg      480

aggtggcagg aggtgtgcaa gcagctgtct gacaggaaga agaggctgga ggagcagcct      540

gacctggccc ctggcctgac aacaattgga gccagcccta cccagacagt gaccctggtg      600

acccagcctg tggtgaccaa ggagacagct atcagcaagc tggagatgcc cagcagcctg      660

atgctggagg tgcctgccct ggctgacttc aacagggcct ggacagagct gacagactgg      720

ctgagcctgc tggaccaggt gatcaagagc cagagggtga tggtggggga cctggaggat      780

atcaatgaga tgattatcaa gcagaaggct acaatgcagg acctggagca gaggaggccc      840

cagctggagg agctgattac agctgcccag aacctaaaga acaagaccag caaccaggag      900

gccaggacaa ttattacaga caggattgag aggatccaga accagtggga tgaggtgcag      960

gagcacctgc agaacaggag gcagcagctg aatgagatgc tgaaggacag tacccagtgg     1020

ctggaggcca aggaggaggc tgagcaggtg ctgggccagg ccagggccaa gctggagagc     1080

tggaaggagg gcccctacac agtggatgcc atccagaaga agatcacaga gaccaagcag     1140

ctggccaagg acctgaggca gtggcagacc aatgtggatg tggccaatga cctggccctg     1200

aagctgctga gggactactc agctgatgac accaggaagg tgcacatgat cacagagaac     1260

atcaatgcca gctggaggag catccacaag agggtgtctg agagggaggc tgccctagag     1320

gagacccaca ggctgctgca gcagttcccc ctggacctgg agaagttcct ggcctggctg     1380

acagaggctg agacaacagc caatgtgctg caggatgcta ccaggaagga gaggctgctg     1440

gaggacagca agggagtgaa ggagctgatg aagcagtggc aggacctaca gggggagatt     1500

gaggcccata cagatgtgta ccacaacctg gatgagaaca gccagaagat cctgaggagc     1560

ctggagggct ctgatgatgc tgtgctgctg cagaggaggc tggacaatat gaacttcaag     1620

tggtctgagc tgaggaagaa gagcctaaat atcaggagcc acctggaggc cagctctgac     1680

cagtggaaga ggctacacct gagcctgcag gagctgctgg tgtggctgca gctgaaggat     1740

gatgagctaa gcaggcaggc ccctattggg ggagacttcc ctgctgtgca gaagcagaat     1800

gatgtgcaca gggccttcaa gagggagctg aagaccaagg agcctgtgat tatgagtacc     1860

ctggagacag tgaggatctt cctgacagag cagcccctgg agggcctgga gaagctgtac     1920

caggagccca gggagctgcc ccctgaggag agggcccaga atgtgaccag gctgctgagg     1980

aagcaggctg aggaggtgaa tacagagtgg gagaagctga acctacactc tgctgactgg     2040

cagaggaaga ttgatgagac cctggagagg ctgcaggagc tgcaggaggc tacagatgag     2100

ctggacctga agctgaggca ggctgaggtg atcaagggca gctggcagcc tgtgggggac     2160

ctgctgattg acagcctaca ggaccacctg gagaaggtga aggccctgag gggagagatt     2220

gcccccctaa aggagaatgt gagtcatgtg aatgacctgg ccaggcagct gaccaccctg     2280

ggcatccagc tgagccccta caacctgagc accctggagg acctgaacac caggtggaag     2340

ctgctgcagg tggctgtgga ggacagggtg aggcagctac atgaggccca cagggacttt     2400

ggccctgcca gccagcactt cctaagcacc tctgttcagg gcccctggga gagggccatc     2460

agccccaaca aggtgcccta ctacatcaac catgagaccc agaccacctg ctgggaccac     2520

cccaagatga cagagctgta ccagagcctg gctgacctga acaatgtgag gttctctgcc     2580

tacaggacag ccatgaagct gaggaggctg cagaaggccc tgtgcctgga cctgctgagc     2640

ctgtctgctg cctgtgatgc cctagaccag cacaacctga agcagaatga ccagcccatg     2700

gacatccttc agatcatcaa ctgcctgacc accatctatg acaggctaga gcaggagcac     2760

aacaacctgg tgaatgtgcc cctgtgtgtg gacatgtgcc tgaactggct gctgaatgtg     2820

tatgacacag gcaggacagg caggatcagg gtgctgagct tcaagacagg catcatcagc     2880

ctatgcaagg ctcacctgga ggacaagtac aggtacctgt tcaagcaggt ggccagcagc     2940

acaggcttct gtgaccagag gaggctgggc ctgctacttc atgacagcat tcagatcccc     3000

aggcagctgg gagaggtggc cagctttgga ggcagcaaca ttgagccctc agtgaggagc     3060

tgcttccagt ttgccaacaa caagcctgag attgaggctg ccctgttcct ggactggatg     3120

aggctggagc ctcagagcat ggtgtggctg cctgtgctgc acagggtggc tgctgctgag     3180

acagccaagc atcaggccaa gtgcaacatc tgcaaggagt gccccatcat tggcttcagg     3240

tacaggagcc taaagcactt caactatgac atctgccaga gctgcttctt ctcaggcagg     3300

gtggccaagg gccacaagat gcactacccc atggtggagt actgcacccc caccacctca     3360

ggagaggatg tgagggactt tgccaaggtg ctgaagaaca agttcaggac caagaggtac     3420

tttgccaagc accccaggat gggctacctg cctgtgcaga cagtgctgga gggggacaac     3480

atggagaccc ctgtgaccct gatcaacttc tggcctgtgg actcagcccc tgccagcagc     3540

ccccagctga gccatgatga cacccacagc aggattgagc actatgccag caggctggct     3600

gagatggaga acagcaatgg cagctaccta aatgacagca tcagccccaa tgagagcatt     3660

gatgatgagc acctgctaat ccagcactac tgccagagcc tgaaccagga cagccccctg     3720

agccagccca ggagccctgc ccagatcctg atcagcctgg agtctgagga gaggggggag     3780

ctggagagga tcctggctga cctggaggag gagaacagga accttcaggc tgagtatgac     3840

aggctaaagc agcagcatga gcacaagggc ctgagccccc tacccagccc ccctgagatg     3900

atgcccacca gcccccagag ccccagggat gctgagctga ttgctgaggc caagctgctg     3960

aggcagcaca agggcaggct ggaggccagg atgcagatcc tagaggacca caacaagcag     4020

ctggagagcc agctacacag gctgaggcag ctgctggagc agcctcaggc tgaggccaag     4080

gtgaatggca ccacagtgag cagccccagc accagcctgc agaggtctga cagcagtcag     4140

cccatgctgc tcagggtggt gggcagtcag acctctgaca gcatgggaga ggaggacctg     4200

ctgagccccc ctcaggacac cagcacaggc ctggaggagg tgatggagca gctgaacaac     4260

agcttcccca gcagcagggg caggaacacc cctggcaagc ccatgaggga ggacaccatg     4320

tagcagacat gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa     4380

aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct     4440

gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggaga     4500

tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg tggtatttac gtagataagt     4560

agcatggcgg gttaatcatt aactacaagg aacccctagt gatggagttg gccactccct     4620

ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct     4680

ttgcccgggc ggcctcagtg agcgagcgag cgcgc                                4715


<210> 8
<211> 4787
<212> DNA
<213> Artificial Sequence


<220> 
<223> WL1 wt 5'AAV

<400> 8
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta tttactagtt      180

ttctcgagtt tggccgtccg ccctcggcac catcctcacg acacccaaat atggcgacgg      240

gtgaggaatg gtggggagtt atttttagag cggtgaggaa ggtgggcagg cagcaggtgt      300

tggcgctcta aaaataactc ccgggagtta tttttagagc ggaggaatgg tggacaccca      360

aatatggcga cggttcctca cccgtcgcca tatttgggtg tccgccctcg gccggggccg      420

cattcctggg ggccgggcgg tgctcccgcc cgcctcgata aaaggctccg gggccggcgg      480

cggcccacga gctacccgga ggagcgggag gcgccaagct ctagagtaag tatcaaggtt      540

acaagacagg tttaaggaga ccaatagaaa ctgggcttgt cgagacagag aagactcttg      600

cgtttctgat aggcacctat tggtcttact gacatccact ttgcctttct ctccacaggc      660

caccatgctt tggtgggaag aagtagagga ctgttatgaa agagaagatg ttcaaaagaa      720

aacattcaca aaatgggtaa atgcacaatt ttctaagttt gggaagcagc atattgagaa      780

cctcttcagt gacctacagg atgggaggcg cctcctagac ctcctcgaag gcctgacagg      840

gcaaaaactg ccaaaagaaa aaggatccac aagagttcat gccctgaaca atgtcaacaa      900

ggcactgcgg gttttgcaga acaataatgt tgatttagtg aatattggaa gtactgacat      960

cgtagatgga aatcataaac tgactcttgg tttgatttgg aatataatcc tccactggca     1020

ggtcaaaaat gtaatgaaaa atatcatggc tggattgcaa caaaccaaca gtgaaaagat     1080

tctcctgagc tgggtccgac aatcaactcg taattatcca caggttaatg taatcaactt     1140

caccaccagc tggtctgatg gcctggcttt gaatgctctc atccatagtc ataggccaga     1200

cctatttgac tggaatagtg tggtttgcca gcagtcagcc acacaacgac tggaacatgc     1260

attcaacatc gccagatatc aattaggcat agagaaacta ctcgatcctg aagatgttga     1320

taccacctat ccagataaga agtccatctt aatgtacatc acatcactct tccaagtttt     1380

gcctcaacaa gtgagcattg aagccatcca ggaagtggaa atgttgccaa ggccacctaa     1440

agtgactaaa gaagaacatt ttcagttaca tcatcaaatg cactattctc aacagatcac     1500

ggtcagtcta gcacagggat atgagagaac ttcttcccct aagcctcgat tcaagagcta     1560

tgcctacaca caggctgctt atgtcaccac ctctgaccct acacggagcc catttccttc     1620

acagcatttg gaagctcctg aagacaagtc atttggcagt tcattgatgg agagtgaagt     1680

aaacctggac cgttatcaaa cagctttaga agaagtatta tcgtggcttc tttctgctga     1740

ggacacattg caagcacaag gagagatttc taatgatgtg gaagtggtga aagaccagtt     1800

tcatactcat gaggggtaca tgatggattt gacagcccat cagggccggg ttggtaatat     1860

tctacaattg ggaagtaagc tgattggaac aggaaaatta tcagaagatg aagaaactga     1920

agtacaagag cagatgaatc tcctaaattc aagatgggaa tgcctcaggg tagctagcat     1980

ggaaaaacaa agcaatttac atagagtttt aatggatctc cagaatcaga aactgaaaga     2040

gttgaatgac tggctaacaa aaacagaaga aagaacaagg aaaatggagg aagagcctct     2100

tggacctgat cttgaagacc taaaacgcca agtacaacaa cataaggtgc ttcaagaaga     2160

tctagaacaa gaacaagtca gggtcaattc tctcactcac atggtggtgg tagttgatga     2220

atctagtgga gatcacgcaa ctgctgcttt ggaagaacaa cttaaggtat tgggagatcg     2280

atgggcaaac atctgtagat ggacagaaga ccgctgggtt cttttacaag acatccttct     2340

caaatggcaa cgtcttactg aagaacagtg cctttttagt gcatggcttt cagaaaaaga     2400

agatgcagtg aacaagattc acacaactgg ctttaaagat caaaatgaaa tgttatcaag     2460

tcttcaaaaa ctggccgttt taaaagcgga tctagaaaag aaaaagcaat ccatgggcaa     2520

actgtattca ctcaaacaag atcttctttc aacactgaag aataagtcag tgacccagaa     2580

gacggaagca tggctggata actttgcccg gtgttgggat aatttagtcc aaaaacttga     2640

aaagagtaca gcacagattt cacaggctgt caccaccact cagccatcac taacacagac     2700

aactgtaatg gaaacagtaa ctacggtgac cacaagggaa cagatcctgg taaagcatgc     2760

tcaagaggaa cttccaccac cacctcccca aaagaagagg cagattactg tggatggttt     2820

ggagaaaact gtaagcctcc agaaagatct atcagagatg cacgaatgga tgacacaagc     2880

tgaagaagag tatcttgaga gagattttga atataaaact ccagatgaat tacagaaagc     2940

agttgaagag atgaagagag ctaaagaaga ggcccaacaa aaagaagcga aagtgaaact     3000

ccttactgag tctgtaaata gtgtcatagc tcaagctcca cctgtagcac aagaggcctt     3060

aaaaaaggaa cttgaaactc taaccaccaa ctaccagtgg ctctgcacta ggctgaatgg     3120

gaaatgcaag actttggaag aagtttgggc atgttggcat gagttattgt catacttgga     3180

gaaagcaaac aagtggctaa atgaagtaga atttaaactt aaaaccactg aaaacattcc     3240

tggcggagct gaggaaatct ctgaggtgct agattcactt gaaaatttga tgcgacattc     3300

agaggataac ccaaatcaga ttcgcatatt ggcacagacc ctaacagatg gcggagtcat     3360

ggatgagcta atcaatgagg aacttgagac atttaattct cgttggaggg aactacatga     3420

agaggctgta aggaggcaaa agttgcttga acagattcac actgtccgtg aagaaacgat     3480

gatggtgatg actgaagaca tgcctttgga aatttcttat gtgccttcta cttatttgac     3540

tgaaatcact catgtctcac aagccctatt agaagtggaa caacttctca atgctcctga     3600

cctctgtgct aaggactttg aagatctctt taagcaagag gagtctctga agaatataaa     3660

agatagtcta caacaaagct caggtcggat tgacattatt catagcaaga agacagcagc     3720

attgcaaagt gcaacgcctg tggaaagggt gaagctacag gaagctctct cccagcttga     3780

tttccaatgg gaaaaagtta acaaaatgta caaggaccga caagggcgat ttgacagatc     3840

tgttgagaaa tggcggcgtt ttcattatga tataaagata tttaatcagt ggctaacaga     3900

agctgaacag tttctcagaa agacacaaat tcctgagaat tgggaacatg ctaaatacaa     3960

atggtatctt aaggaactcc aggatggcat tgggcagcgg caaactgttg tcagaacatt     4020

gaatgcaact ggggaagaaa taattcagca atcctcaaaa acagatgcca gtattctaca     4080

ggaaaaattg ggaagcctga atctgcggtg gcaggaggtc tgcaaacagc tgtcagacag     4140

aaaaaagagg ctagaagagc agcctgacct agctcctgga ctgaccacta ttggagcctc     4200

tcctactcag actgttactc tggtgacaca acctgtggtt actaaggaaa ctgccatctc     4260

caaactagaa atgccatctt ccttgatgtt ggaggtacct gctctggcag atttcaaccg     4320

ggcttggaca gaacttaccg actggctttc tctgcttgat caagttataa aatcacagag     4380

ggtgatggtg ggtgaccttg aggatatcaa cgagatgatc atcaagcaga aggcaacaat     4440

gcaggatttg gaacagaggc gtccccagtt ggaagaactc attaccgctg cccaaaattt     4500

gaaaaacaag accagcaatc aagaggctag aacaatcatt acggatcgaa ttgaaagaat     4560

tcagaatcag tgggatgaag tacaagaaca ccttcagttt acgcgttttg cggccgcttt     4620

acgtagataa gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt     4680

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     4740

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgc                   4787


<210> 9
<211> 4753
<212> DNA
<213> Artificial Sequence


<220> 
<223> WL1 wt 3'AAV

<400> 9
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta tttgcggccg      180

ctttacgcgt ttttaacaaa atgtacaagg accgacaagg gcgatttgac agatctgttg      240

agaaatggcg gcgttttcat tatgatataa agatatttaa tcagtggcta acagaagctg      300

aacagtttct cagaaagaca caaattcctg agaattggga acatgctaaa tacaaatggt      360

atcttaagga actccaggat ggcattgggc agcggcaaac tgttgtcaga acattgaatg      420

caactgggga agaaataatt cagcaatcct caaaaacaga tgccagtatt ctacaggaaa      480

aattgggaag cctgaatctg cggtggcagg aggtctgcaa acagctgtca gacagaaaaa      540

agaggctaga agagcagcct gacctagctc ctggactgac cactattgga gcctctccta      600

ctcagactgt tactctggtg acacaacctg tggttactaa ggaaactgcc atctccaaac      660

tagaaatgcc atcttccttg atgttggagg tacctgctct ggcagatttc aaccgggctt      720

ggacagaact taccgactgg ctttctctgc ttgatcaagt tataaaatca cagagggtga      780

tggtgggtga ccttgaggat atcaacgaga tgatcatcaa gcagaaggca acaatgcagg      840

atttggaaca gaggcgtccc cagttggaag aactcattac cgctgcccaa aatttgaaaa      900

acaagaccag caatcaagag gctagaacaa tcattacgga tcgaattgaa agaattcaga      960

atcagtggga tgaagtacaa gaacaccttc agaaccggcg ccaacagttg aatgaaatgt     1020

taaaggattc aacacaatgg ctggaagcta aggaagaagc tgagcaggtc ttaggacagg     1080

ccagagccaa gcttgagtca tggaaggagg gtccctatac agtagatgca atccaaaaga     1140

aaatcacaga aaccaagcag ttggccaaag acctccgcca gtggcagaca aatgtagatg     1200

tggcaaatga cttggccctg aaacttctcc gggattattc tgcagatgat accagaaaag     1260

tccacatgat aacagagaat atcaatgcct cttggagaag cattcataaa agggtgagtg     1320

agcgagaggc tgctttggaa gaaactcata gattactgca acagttcccc ctggacctgg     1380

aaaagtttct tgcctggctt acagaagctg aaacaactgc caatgtccta caggatgcta     1440

cccgtaagga aaggctccta gaagactcca agggagtaaa agagctgatg aaacaatggc     1500

aagacctcca aggtgaaatt gaagctcaca cagatgttta tcacaacctg gatgaaaaca     1560

gccaaaaaat cctgagatcc ctggaaggtt ccgatgatgc agtcctgtta caaagacgtt     1620

tggataacat gaacttcaag tggagtgaac ttcggaaaaa gtctctcaac attaggtccc     1680

atttggaagc cagttctgac cagtggaagc gtctgcacct ttctctgcag gaacttctgg     1740

tgtggctaca gctgaaagat gatgaattaa gccggcaggc acctattgga ggcgactttc     1800

cagcagttca gaagcagaac gatgtacata gggccttcaa gagggaattg aaaactaaag     1860

aacctgtaat catgagtact cttgagactg tacgaatatt tctgacagag cagcctttgg     1920

aaggactaga gaaactctac caggagccca gagagctgcc tcctgaggag agagcccaga     1980

atgtcactcg gcttctacga aagcaggctg aggaggtcaa tactgagtgg gaaaaattga     2040

acctgcactc cgctgactgg cagagaaaaa tagatgagac ccttgaaaga ctccaggaac     2100

ttcaagaggc cacggatgag ctggacctca agctgcgcca agctgaggtg atcaagggat     2160

cctggcagcc cgtgggcgat ctcctcattg actctctcca agatcacctc gagaaagtca     2220

aggcacttcg aggagaaatt gcgcctctga aagagaacgt gagccacgtc aatgaccttg     2280

ctcgccagct taccactttg ggcattcagc tctcaccgta taacctcagc actctggaag     2340

acctgaacac cagatggaag cttctgcagg tggccgtcga ggaccgagtc aggcagctgc     2400

atgaagccca cagggacttt ggtccagcat ctcagcactt tctttccacg tctgtccagg     2460

gtccctggga gagagccatc tcgccaaaca aagtgcccta ctatatcaac cacgagactc     2520

aaacaacttg ctgggaccat cccaaaatga cagagctcta ccagtcttta gctgacctga     2580

ataatgtcag attctcagct tataggactg ccatgaaact ccgaagactg cagaaggccc     2640

tttgcttgga tctcttgagc ctgtcagctg catgtgatgc cttggaccag cacaacctca     2700

agcaaaatga ccagcccatg gatatcctgc agattattaa ttgtttgacc actatttatg     2760

accgcctgga gcaagagcac aacaatttgg tcaacgtccc tctctgcgtg gatatgtgtc     2820

tgaactggct gctgaatgtt tatgatacgg gacgaacagg gaggatccgt gtcctgtctt     2880

ttaaaactgg catcatttcc ctgtgtaaag cacatttgga agacaagtac agataccttt     2940

tcaagcaagt ggcaagttca acaggatttt gtgaccagcg caggctgggc ctccttctgc     3000

atgattctat ccaaattcca agacagttgg gtgaagttgc atcctttggg ggcagtaaca     3060

ttgagccaag tgtccggagc tgcttccaat ttgctaataa taagccagag atcgaagcgg     3120

ccctcttcct agactggatg agactggaac cccagtccat ggtgtggctg cccgtcctgc     3180

acagagtggc tgctgcagaa actgccaagc atcaggccaa atgtaacatc tgcaaagagt     3240

gtccaatcat tggattcagg tacaggagtc taaagcactt taattatgac atctgccaaa     3300

gctgcttttt ttctggtcga gttgcaaaag gccataaaat gcactatccc atggtggaat     3360

attgcactcc gactacatca ggagaagatg ttcgagactt tgccaaggta ctaaaaaaca     3420

aatttcgaac caaaaggtat tttgcgaagc atccccgaat gggctacctg ccagtgcaga     3480

ctgtcttaga gggggacaac atggaaactc ccgttactct gatcaacttc tggccagtag     3540

attctgcgcc tgcctcgtcc cctcagcttt cacacgatga tactcattca cgcattgaac     3600

attatgctag caggctagca gaaatggaaa acagcaatgg atcttatcta aatgatagca     3660

tctctcctaa tgagagcata gatgatgaac atttgttaat ccagcattac tgccaaagtt     3720

tgaaccagga ctcccccctg agccagcctc gtagtcctgc ccagatcttg atttccttag     3780

agagtgagga aagaggggag ctagagagaa tcctagcaga tcttgaggaa gaaaacagga     3840

atctgcaagc agaatatgac cgtctaaagc agcagcacga acataaaggc ctgtccccac     3900

tgccgtcccc tcctgaaatg atgcccacct ctccccagag tccccgggat gctgagctca     3960

ttgctgaggc caagctactg cgtcaacaca aaggccgcct ggaagccagg atgcaaatcc     4020

tggaagacca caataaacag ctggagtcac agttacacag gctaaggcag ctgctggagc     4080

aaccccaggc agaggccaaa gtgaatggca caacggtgtc ctctccttct acctctctac     4140

agaggtccga cagcagtcag cctatgctgc tccgagtggt tggcagtcaa acttcggact     4200

ccatgggtga ggaagatctt ctcagtcctc cccaggacac aagcacaggg ttagaggagg     4260

tgatggagca actcaacaac tccttcccta gttcaagagg aagaaatacc cctggaaagc     4320

caatgagaga ggacacaatg tagcagacat gataagatac attgatgagt ttggacaaac     4380

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt     4440

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat     4500

gtttcaggtt cagggggaga tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg     4560

tggtattgtc gactttacta gtttttacgt agataagtag catggcgggt taatcattaa     4620

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4680

tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag     4740

cgagcgagcg cgc                                                        4753


<210> 10
<211> 800
<212> DNA
<213> Artificial Sequence


<220> 
<223> HR WL1 partial OPT1

<400> 10
ttaacaagat gtacaaggac cggcaggggc ggttcgaccg gtcggtggag aagtggcggc      60

ggttccacta cgacatcaag atcttcaacc agtggctgac ggaggcggag cagttcctgc     120

ggaagacgca gatcccggag aactgggagc acgcgaagta caagtggtac ctgaaggagc     180

tgcaggacgg catcgggcag cggcagacgg tggtccggac gctgaacgcg acgggggagg     240

agatcatcca gcagtcctcg aagacggacg cctcgatcct gcaggagaag ctggggagcc     300

tgaacctgcg gtggcaggag gtctgcaagc agctgtcgga ccggaagaag cggctggagg     360

agcagccgga cctcgcgccg gggctgacca cgatcggggc ctcgccgacg cagacggtga     420

cgctggtgac gcagccggtg gtgacgaagg agacggccat ctccaagctg gagatgccgt     480

cgtccctgat gctggaggtg ccggcgctgg cggacttcaa ccgggcgtgg acggagctga     540

ccgactggct gtcgctgctg gaccaggtga tcaagtcgca gagggtgatg gtgggcgacc     600

tggaggacat caacgagatg atcatcaagc agaaggcgac gatgcaggac ctggagcagc     660

ggcggcccca gctggaggag ctgatcaccg cggcccagaa cctgaagaac aagacctcga     720

accaggaggc gcggacgatc atcacggacc ggatcgagcg gatccagaac cagtgggacg     780

aggtgcagga gcacctgcag                                                 800


<210> 11
<211> 800
<212> DNA
<213> Artificial Sequence


<220> 
<223> HR WL1 partial OPT2

<400> 11
ttaacaagat gtacaaggac aggcagggga ggtttgacag gtctgtggag aagtggagga      60

ggttccacta tgacatcaag atcttcaacc agtggctgac agaggctgag cagttcctca     120

ggaagaccca gatccctgag aactgggagc atgccaagta caagtggtac ctgaaggagc     180

tccaggatgg cattgggcag aggcagactg tggtcaggac cctgaatgcc actggggagg     240

agatcatcca gcagtcctcc aagacagatg ccagcatcct gcaggagaag ctggggagcc     300

tgaacctgag gtggcaggag gtctgcaagc agctgtcaga caggaagaag aggctggagg     360

agcagcctga cctggcccct ggcctgacca ccattggggc ctcccccacc cagactgtga     420

ccctggtgac ccagcctgtg gtgaccaagg agactgccat ctccaagctg gagatgccct     480

cctccctgat gctggaggtg cctgccctgg cagacttcaa cagggcctgg acagagctga     540

ctgactggct gtccctgctg gaccaggtga tcaagtccca gagggtgatg gtgggggacc     600

tggaggacat caatgagatg atcatcaagc agaaggccac catgcaggac ctggagcaga     660

ggaggcccca gctggaggag ctcatcactg ctgcccagaa cctgaagaac aagaccagca     720

accaggaggc caggaccatc atcactgaca ggattgagag gatccagaac cagtgggatg     780

aggtgcagga gcacctgcag                                                 800


<210> 12
<211> 800
<212> DNA
<213> Artificial Sequence


<220> 
<223> HR WL1 OPT

<400> 12
ttaacaagat gtacaaggac aggcagggca ggtttgacag gtcagtggag aagtggagga      60

ggttccacta tgacatcaag atcttcaacc agtggctgac agaggctgag cagttcctaa     120

ggaagaccca gatccctgag aactgggagc atgccaagta caagtggtac cttaaggagc     180

tgcaggatgg cattggccag aggcagacag tggtgaggac cctgaatgct acaggggagg     240

agattatcca gcagagcagc aagacagatg ccagtatcct gcaggagaag ctgggcagcc     300

tgaacctgag gtggcaggag gtgtgcaagc agctgtctga caggaagaag aggctggagg     360

agcagcctga cctggcccct ggcctgacaa caattggagc cagccctacc cagacagtga     420

ccctggtgac ccagcctgtg gtgaccaagg agacagctat cagcaagctg gagatgccca     480

gcagcctgat gctggaggtg cctgccctgg ctgacttcaa cagggcctgg acagagctga     540

cagactggct gagcctgctg gaccaggtga tcaagagcca gagggtgatg gtgggggacc     600

tggaggatat caatgagatg attatcaagc agaaggctac aatgcaggac ctggagcaga     660

ggaggcccca gctggaggag ctgattacag ctgcccagaa cctaaagaac aagaccagca     720

accaggaggc caggacaatt attacagaca ggattgagag gatccagaac cagtgggatg     780

aggtgcagga gcacctgcag                                                 800


<210> 13
<211> 4687
<212> DNA
<213> Artificial Sequence


<220> 
<223> WL2 wt 5'AAV

<400> 13
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta ttggccgtcc      180

gccctcggca ccatcctcac gacacccaaa tatggcgacg ggtgaggaat ggtggggagt      240

tatttttaga gcggtgagga aggtgggcag gcagcaggtg ttggcgctct aaaaataact      300

cccgggagtt atttttagag cggaggaatg gtggacaccc aaatatggcg acggttcctc      360

acccgtcgcc atatttgggt gtccgccctc ggccggggcc gcattcctgg gggccgggcg      420

gtgctcccgc ccgcctcgat aaaaggctcc ggggccggcg gcggcccacg agctacccgg      480

aggagcggga ggcgccaagc tctagagtaa gtatcaaggt tacaagacag gtttaaggag      540

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta      600

ttggtcttac tgacatccac tttgcctttc tctccacagg ccaccatgct ttggtgggaa      660

gaagtagagg actgttatga aagagaagat gttcaaaaga aaacattcac aaaatgggta      720

aatgcacaat tttctaagtt tgggaagcag catattgaga acctcttcag tgacctacag      780

gatgggaggc gcctcctaga cctcctcgaa ggcctgacag ggcaaaaact gccaaaagaa      840

aaaggatcca caagagttca tgccctgaac aatgtcaaca aggcactgcg ggttttgcag      900

aacaataatg ttgatttagt gaatattgga agtactgaca tcgtagatgg aaatcataaa      960

ctgactcttg gtttgatttg gaatataatc ctccactggc aggtcaaaaa tgtaatgaaa     1020

aatatcatgg ctggattgca acaaaccaac agtgaaaaga ttctcctgag ctgggtccga     1080

caatcaactc gtaattatcc acaggttaat gtaatcaact tcaccaccag ctggtctgat     1140

ggcctggctt tgaatgctct catccatagt cataggccag acctatttga ctggaatagt     1200

gtggtttgcc agcagtcagc cacacaacga ctggaacatg cattcaacat cgccagatat     1260

caattaggca tagagaaact actcgatcct gaagatgttg ataccaccta tccagataag     1320

aagtccatct taatgtacat cacatcactc ttccaagttt tgcctcaaca agtgagcatt     1380

gaagccatcc aggaagtgga aatgttgcca aggccaccta aagtgactaa agaagaacat     1440

tttcagttac atcatcaaat gcactattct caacagatca cggtcagtct agcacaggga     1500

tatgagagaa cttcttcccc taagcctcga ttcaagagct atgcctacac acaggctgct     1560

tatgtcacca cctctgaccc tacacggagc ccatttcctt cacagcattt ggaagctcct     1620

gaagacaagt catttggcag ttcattgatg gagagtgaag taaacctgga ccgttatcaa     1680

acagctttag aagaagtatt atcgtggctt ctttctgctg aggacacatt gcaagcacaa     1740

ggagagattt ctaatgatgt ggaagtggtg aaagaccagt ttcatactca tgaggggtac     1800

atgatggatt tgacagccca tcagggccgg gttggtaata ttctacaatt gggaagtaag     1860

ctgattggaa caggaaaatt atcagaagat gaagaaactg aagtacaaga gcagatgaat     1920

ctcctaaatt caagatggga atgcctcagg gtagctagca tggaaaaaca aagcaattta     1980

catagagttt taatggatct ccagaatcag aaactgaaag agttgaatga ctggctaaca     2040

aaaacagaag aaagaacaag gaaaatggag gaagagcctc ttggacctga tcttgaagac     2100

ctaaaacgcc aagtacaaca acataaggtg cttcaagaag atctagaaca agaacaagtc     2160

agggtcaatt ctctcactca catggtggtg gtagttgatg aatctagtgg agatcacgca     2220

actgctgctt tggaagaaca acttaaggta ttgggagatc gatgggcaaa catctgtaga     2280

tggacagaag accgctgggt tcttttacaa gacatccttc tcaaatggca acgtcttact     2340

gaagaacagt gcctttttag tgcatggctt tcagaaaaag aagatgcagt gaacaagatt     2400

cacacaactg gctttaaaga tcaaaatgaa atgttatcaa gtcttcaaaa actggccgtt     2460

ttaaaagcgg atctagaaaa gaaaaagcaa tccatgggca aactgtattc actcaaacaa     2520

gatcttcttt caacactgaa gaataagtca gtgacccaga agacggaagc atggctggat     2580

aactttgccc ggtgttggga taatttagtc caaaaacttg aaaagagtac agcacagatt     2640

tcacaggctg tcaccaccac tcagccatca ctaacacaga caactgtaat ggaaacagta     2700

actacggtga ccacaaggga acagatcctg gtaaagcatg ctcaagagga acttccacca     2760

ccacctcccc aaaagaagag gcagattact gtggatggtt tggagaaaac tgtaagcctc     2820

cagaaagatc tatcagagat gcacgaatgg atgacacaag ctgaagaaga gtatcttgag     2880

agagattttg aatataaaac tccagatgaa ttacagaaag cagttgaaga gatgaagaga     2940

gctaaagaag aggcccaaca aaaagaagcg aaagtgaaac tccttactga gtctgtaaat     3000

agtgtcatag ctcaagctcc acctgtagca caagaggcct taaaaaagga acttgaaact     3060

ctaaccacca actaccagtg gctctgcact aggctgaatg ggaaatgcaa gactttggaa     3120

gaagtttggg catgttggca tgagttattg tcatacttgg agaaagcaaa caagtggcta     3180

aatgaagtag aatttaaact taaaaccact gaaaacattc ctggcggagc tgaggaaatc     3240

tctgaggtgc tagattcact tgaaaatttg atgcgacatt cagaggataa cccaaatcag     3300

attcgcatat tggcacagac cctaacagat ggcggagtca tggatgagct aatcaatgag     3360

gaacttgaga catttaattc tcgttggagg gaactacatg aagaggctgt aaggaggcaa     3420

aagttgcttg aacagccttt gaaggaattg gagcagttta actcagatat acaaaaattg     3480

cttgaaccac tggaggctga aattcagcag ggggtgaatc tgaaagagga agacttcaat     3540

aaagatatga atgaagacaa tgagggtact gtaaaagaat tgttgcaaag aggagacaac     3600

ttacaacaaa gaatcacaga tgagagaaag agagaggaaa taaagataaa acagcagctg     3660

ttacagacaa aacataacgc gttcaaggat ttgaggtctc aaagaagaaa aaaggctcta     3720

gaaatttctc atcagtggta tcagtacaag aggcaggctg atgatctcct gaaatgcttg     3780

gatgacattg aaaaaaaatt agccagccta cctgagccca gagatgaaag gaaaataaag     3840

gaaattgatc gggaattgca gaagaagaaa gaggagctga atgcagtgcg taggcaagct     3900

gagggcttgt ctgaggatgg ggccgcaatg gcagtggagc caactcagat ccagctcagc     3960

aagcgctggc gggaaattga gagcaaattt gctcagtttc gaagactcaa ctttgcacaa     4020

attcacactg tccgtgaaga aacgatgatg gtgatgactg aagacatgcc tttggaaatt     4080

tcttatgtgc cttctactta tttgactgaa atcactcatg tctcacaagc cctattagaa     4140

gtggaacaac ttctcaatgc tcctgacctc tgtgctaagg actttgaaga tctctttaag     4200

caagaggagt ctctgaagaa tataaaagat agtctacaac aaagctcagg tcggattgac     4260

attattcata gcaagaagac agcagcattg caaagtgcaa cgcctgtgga aagggtgaag     4320

ctacaggaag ctctctccca gcttgatttc caatgggaaa aagttaacaa aatgtacaag     4380

gaccgacaag ggcgatttga cagatctgtt gagaaatggc ggcgttttca ttatgatata     4440

aagatattta atcagtggct aacagaagct gaacagtttc tcagaaagac acaaattcct     4500

accggttttg cggccgcttt acgtagataa gtagcatggc gggttaatca ttaactacaa     4560

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     4620

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg     4680

agcgcgc                                                               4687


<210> 14
<211> 4739
<212> DNA
<213> Artificial Sequence


<220> 
<223> WL2 wt 3'AAV

<400> 14
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta ttacgcgttt      180

taaagaagaa aaaaggctct agaaatttct catcagtggt atcagtacaa gaggcaggct      240

gatgatctcc tgaaatgctt ggatgacatt gaaaaaaaat tagccagcct acctgagccc      300

agagatgaaa ggaaaataaa ggaaattgat cgggaattgc agaagaagaa agaggagctg      360

aatgcagtgc gtaggcaagc tgagggcttg tctgaggatg gggccgcaat ggcagtggag      420

ccaactcaga tccagctcag caagcgctgg cgggaaattg agagcaaatt tgctcagttt      480

cgaagactca actttgcaca aattcacact gtccgtgaag aaacgatgat ggtgatgact      540

gaagacatgc ctttggaaat ttcttatgtg ccttctactt atttgactga aatcactcat      600

gtctcacaag ccctattaga agtggaacaa cttctcaatg ctcctgacct ctgtgctaag      660

gactttgaag atctctttaa gcaagaggag tctctgaaga atataaaaga tagtctacaa      720

caaagctcag gtcggattga cattattcat agcaagaaga cagcagcatt gcaaagtgca      780

acgcctgtgg aaagggtgaa gctacaggaa gctctctccc agcttgattt ccaatgggaa      840

aaagttaaca aaatgtacaa ggaccgacaa gggcgatttg acagatctgt tgagaaatgg      900

cggcgttttc attatgatat aaagatattt aatcagtggc taacagaagc tgaacagttt      960

ctcagaaaga cacaaattcc tgagaattgg gaacatgcta aatacaaatg gtatcttaag     1020

gaactccagg atggcattgg gcagcggcaa actgttgtca gaacattgaa tgcaactggg     1080

gaagaaataa ttcagcaatc ctcaaaaaca gatgccagta ttctacagga aaaattggga     1140

agcctgaatc tgcggtggca ggaggtctgc aaacagctgt cagacagaaa aaagaggcta     1200

gaagagcagc ctgacctagc tcctggactg accactattg gagcctctcc tactcagact     1260

gttactctgg tgacacaacc tgtggttact aaggaaactg ccatctccaa actagaaatg     1320

ccatcttcct tgatgttgga ggtaccaact catagattac tgcaacagtt ccccctggac     1380

ctggaaaagt ttcttgcctg gcttacagaa gctgaaacaa ctgccaatgt cctacaggat     1440

gctacccgta aggaaaggct cctagaagac tccaagggag taaaagagct gatgaaacaa     1500

tggcaagacc tccaaggtga aattgaagct cacacagatg tttatcacaa cctggatgaa     1560

aacagccaaa aaatcctgag atccctggaa ggttccgatg atgcagtcct gttacaaaga     1620

cgtttggata acatgaactt caagtggagt gaacttcgga aaaagtctct caacattagg     1680

tcccatttgg aagccagttc tgaccagtgg aagcgtctgc acctttctct gcaggaactt     1740

ctggtgtggc tacagctgaa agatgatgaa ttaagccggc aggcacctat tggaggcgac     1800

tttccagcag ttcagaagca gaacgatgta catagggcct tcaagaggga attgaaaact     1860

aaagaacctg taatcatgag tactcttgag actgtacgaa tatttctgac agagcagcct     1920

ttggaaggac tagagaaact ctaccaggag cccagagagc tgcctcctga ggagagagcc     1980

cagaatgtca ctcggcttct acgaaagcag gctgaggagg tcaatactga gtgggaaaaa     2040

ttgaacctgc actccgctga ctggcagaga aaaatagatg agacccttga aagactccag     2100

gaacttcaag aggccacgga tgagctggac ctcaagctgc gccaagctga ggtgatcaag     2160

ggatcctggc agcccgtggg cgatctcctc attgactctc tccaagatca cctcgagaaa     2220

gtcaaggcac ttcgaggaga aattgcgcct ctgaaagaga acgtgagcca cgtcaatgac     2280

cttgctcgcc agcttaccac tttgggcatt cagctctcac cgtataacct cagcactctg     2340

gaagacctga acaccagatg gaagcttctg caggtggccg tcgaggaccg agtcaggcag     2400

ctgcatgaag cccacaggga ctttggtcca gcatctcagc actttctttc cacgtctgtc     2460

cagggtccct gggagagagc catctcgcca aacaaagtgc cctactatat caaccacgag     2520

actcaaacaa cttgctggga ccatcccaaa atgacagagc tctaccagtc tttagctgac     2580

ctgaataatg tcagattctc agcttatagg actgccatga aactccgaag actgcagaag     2640

gccctttgct tggatctctt gagcctgtca gctgcatgtg atgccttgga ccagcacaac     2700

ctcaagcaaa atgaccagcc catggatatc ctgcagatta ttaattgttt gaccactatt     2760

tatgaccgcc tggagcaaga gcacaacaat ttggtcaacg tccctctctg cgtggatatg     2820

tgtctgaact ggctgctgaa tgtttatgat acgggacgaa cagggaggat ccgtgtcctg     2880

tcttttaaaa ctggcatcat ttccctgtgt aaagcacatt tggaagacaa gtacagatac     2940

cttttcaagc aagtggcaag ttcaacagga ttttgtgacc agcgcaggct gggcctcctt     3000

ctgcatgatt ctatccaaat tccaagacag ttgggtgaag ttgcatcctt tgggggcagt     3060

aacattgagc caagtgtccg gagctgcttc caatttgcta ataataagcc agagatcgaa     3120

gcggccctct tcctagactg gatgagactg gaaccccagt ccatggtgtg gctgcccgtc     3180

ctgcacagag tggctgctgc agaaactgcc aagcatcagg ccaaatgtaa catctgcaaa     3240

gagtgtccaa tcattggatt caggtacagg agtctaaagc actttaatta tgacatctgc     3300

caaagctgct ttttttctgg tcgagttgca aaaggccata aaatgcacta tcccatggtg     3360

gaatattgca ctccgactac atcaggagaa gatgttcgag actttgccaa ggtactaaaa     3420

aacaaatttc gaaccaaaag gtattttgcg aagcatcccc gaatgggcta cctgccagtg     3480

cagactgtct tagaggggga caacatggaa actcccgtta ctctgatcaa cttctggcca     3540

gtagattctg cgcctgcctc gtcccctcag ctttcacacg atgatactca ttcacgcatt     3600

gaacattatg ctagcaggct agcagaaatg gaaaacagca atggatctta tctaaatgat     3660

agcatctctc ctaatgagag catagatgat gaacatttgt taatccagca ttactgccaa     3720

agtttgaacc aggactcccc cctgagccag cctcgtagtc ctgcccagat cttgatttcc     3780

ttagagagtg aggaaagagg ggagctagag agaatcctag cagatcttga ggaagaaaac     3840

aggaatctgc aagcagaata tgaccgtcta aagcagcagc acgaacataa aggcctgtcc     3900

ccactgccgt cccctcctga aatgatgccc acctctcccc agagtccccg ggatgctgag     3960

ctcattgctg aggccaagct actgcgtcaa cacaaaggcc gcctggaagc caggatgcaa     4020

atcctggaag accacaataa acagctggag tcacagttac acaggctaag gcagctgctg     4080

gagcaacccc aggcagaggc caaagtgaat ggcacaacgg tgtcctctcc ttctacctct     4140

ctacagaggt ccgacagcag tcagcctatg ctgctccgag tggttggcag tcaaacttcg     4200

gactccatgg gtgaggaaga tcttctcagt cctccccagg acacaagcac agggttagag     4260

gaggtgatgg agcaactcaa caactccttc cctagttcaa gaggaagaaa tacccctgga     4320

aagccaatga gagaggacac aatgtagcag acatgataag atacattgat gagtttggac     4380

aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt gatgctattg     4440

ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat tgcattcatt     4500

ttatgtttca ggttcagggg gagatgtggg aggtttttta aagcaagtaa aacctctaca     4560

aatgtggtat ttacgtagat aagtagcatg gcgggttaat cattaactac aaggaacccc     4620

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     4680

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgc      4739


<210> 15
<211> 800
<212> DNA
<213> Artificial Sequence


<220> 
<223> HR WL2 partial OPT1

<400> 15
agcggcggaa gaaggccctg gagatctccc accagtggta ccagtacaag cggcaggccg      60

acgacctcct gaagtgcctg gacgacatcg agaagaagct ggccagcctg ccggagcccc     120

gggacgagcg caagatcaag gagatcgacc gggagctgca gaagaagaag gaggagctga     180

acgccgtgcg ccggcaggcc gagggcctgt ccgaggacgg ggccgccatg gccgtggagc     240

ccacccagat ccagctcagc aagcgctggc gggagatcga gagcaagttc gcccagttcc     300

ggcgcctcaa cttcgcccag atccacaccg tccgggagga gacgatgatg gtgatgaccg     360

aggacatgcc cctggagatc tcctacgtgc cctccaccta cctgaccgag atcacccacg     420

tctcccaggc cctgctggag gtggagcagc tcctcaacgc ccccgacctc tgcgccaagg     480

acttcgagga cctcttcaag caggaggagt ccctgaagaa catcaaggac agcctgcagc     540

agagctccgg gcggatcgac atcatccaca gcaagaagac cgccgccctg cagagcgcca     600

cgcccgtgga gcgggtgaag ctgcaggagg ccctctccca gctggacttc cagtgggaga     660

aggtgaacaa gatgtacaag gaccggcagg ggcggttcga ccgctccgtg gagaagtggc     720

ggcgcttcca ctacgacatc aagatcttca accagtggct gaccgaggcc gagcagttcc     780

tccggaagac ccagatcccc                                                 800


<210> 16
<211> 800
<212> DNA
<213> Artificial Sequence


<220> 
<223> HR WL2 partial OPT2

<400> 16
agaggaggaa gaaggccctg gagatcagcc accagtggta ccagtacaag aggcaggctg      60

atgacctcct gaagtgcctg gatgacattg agaagaagct ggccagcctc cctgagccca     120

gggatgagag gaagatcaag gagattgaca gggagctgca gaagaagaag gaggagctga     180

atgcagtgag gaggcaggct gagggcctgt ctgaggatgg ggctgccatg gcagtggagc     240

ccacccagat ccagctcagc aagaggtgga gggagattga gagcaagttt gcccagttca     300

ggaggctcaa ctttgcccag atccacactg tcagggagga gaccatgatg gtgatgactg     360

aggacatgcc cctggagatc agctatgtgc ccagcaccta cctgactgag atcacccatg     420

tcagccaggc cctcctggag gtggagcagc tcctcaatgc ccctgacctc tgtgccaagg     480

actttgagga cctcttcaag caggaggaga gcctgaagaa catcaaggac agcctgcagc     540

agagctcagg caggattgac atcatccaca gcaagaagac agcagccctg cagagtgcca     600

cccctgtgga gagggtgaag ctgcaggagg ccctcagcca gctggacttc cagtgggaga     660

aggtgaacaa gatgtacaag gacaggcagg ggaggtttga caggagtgtg gagaagtgga     720

ggaggttcca ctatgacatc aagatcttca accagtggct gacagaggct gagcagttcc     780

tcaggaagac ccagatccct                                                 800


<210> 17
<211> 800
<212> DNA
<213> Artificial Sequence


<220> 
<223> HR WL2 OPT

<400> 17
agaggaggaa gaaggccctg gagatcagcc accagtggta ccagtacaag aggcaggctg      60

atgacctgct gaagtgcctg gatgacattg agaagaagct ggccagcctg cctgagccca     120

gggatgagag gaagatcaag gagattgaca gggagctgca gaagaagaag gaggagctga     180

atgctgtgag gaggcaggct gagggcctgt ctgaggatgg ggctgccatg gctgtggagc     240

ccacccagat ccagctgagc aagaggtgga gggagattga gagcaagttt gcccagttca     300

ggaggctgaa ctttgcccag atccacactg tgagggagga gaccatgatg gtgatgacag     360

aggacatgcc cctggagatc agctatgtgc ccagcaccta cctgactgag atcacccatg     420

tgagccaggc cctgctggag gtggagcagc tgctgaatgc ccctgacctg tgtgccaagg     480

actttgagga cctgttcaag caggaggaga gcctgaagaa catcaaggac agcctgcagc     540

agagctctgg caggattgac atcatccaca gcaagaagac tgctgccctg cagtctgcca     600

cccctgtgga gagggtgaag ctgcaggagg ccctgagcca gctggacttc cagtgggaga     660

aggtgaacaa gatgtacaag gacaggcagg gcaggtttga caggtctgtg gagaagtgga     720

ggaggttcca ctatgacatc aagatcttca accagtggct gactgaggct gagcagttcc     780

tgaggaagac ccagatccct                                                 800


<210> 18
<211> 4655
<212> DNA
<213> Artificial Sequence


<220> 
<223> DD 5'AAV

<400> 18
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta tttactagtt      180

ttctcgagtt tggccgtccg ccctcggcac catcctcacg acacccaaat atggcgacgg      240

gtgaggaatg gtggggagtt atttttagag cggtgaggaa ggtgggcagg cagcaggtgt      300

tggcgctcta aaaataactc ccgggagtta tttttagagc ggaggaatgg tggacaccca      360

aatatggcga cggttcctca cccgtcgcca tatttgggtg tccgccctcg gccggggccg      420

cattcctggg ggccgggcgg tgctcccgcc cgcctcgata aaaggctccg gggccggcgg      480

cggcccacga gctacccgga ggagcgggag gcgccaagct ctagagtaag tatcaaggtt      540

acaagacagg tttaaggaga ccaatagaaa ctgggcttgt cgagacagag aagactcttg      600

cgtttctgat aggcacctat tggtcttact gacatccact ttgcctttct ctccacaggc      660

caccatgctt tggtgggaag aagtagagga ctgttatgaa agagaagatg ttcaaaagaa      720

aacattcaca aaatgggtaa atgcacaatt ttctaagttt gggaagcagc atattgagaa      780

cctcttcagt gacctacagg atgggaggcg cctcctagac ctcctcgaag gcctgacagg      840

gcaaaaactg ccaaaagaaa aaggatccac aagagttcat gccctgaaca atgtcaacaa      900

ggcactgcgg gttttgcaga acaataatgt tgatttagtg aatattggaa gtactgacat      960

cgtagatgga aatcataaac tgactcttgg tttgatttgg aatataatcc tccactggca     1020

ggtcaaaaat gtaatgaaaa atatcatggc tggattgcaa caaaccaaca gtgaaaagat     1080

tctcctgagc tgggtccgac aatcaactcg taattatcca caggttaatg taatcaactt     1140

caccaccagc tggtctgatg gcctggcttt gaatgctctc atccatagtc ataggccaga     1200

cctatttgac tggaatagtg tggtttgcca gcagtcagcc acacaacgac tggaacatgc     1260

attcaacatc gccagatatc aattaggcat agagaaacta ctcgatcctg aagatgttga     1320

taccacctat ccagataaga agtccatctt aatgtacatc acatcactct tccaagtttt     1380

gcctcaacaa gtgagcattg aagccatcca ggaagtggaa atgttgccaa ggccacctaa     1440

agtgactaaa gaagaacatt ttcagttaca tcatcaaatg cactattctc aacagatcac     1500

ggtcagtcta gcacagggat atgagagaac ttcttcccct aagcctcgat tcaagagcta     1560

tgcctacaca caggctgctt atgtcaccac ctctgaccct acacggagcc catttccttc     1620

acagcatttg gaagctcctg aagacaagtc atttggcagt tcattgatgg agagtgaagt     1680

aaacctggac cgttatcaaa cagctttaga agaagtatta tcgtggcttc tttctgctga     1740

ggacacattg caagcacaag gagagatttc taatgatgtg gaagtggtga aagaccagtt     1800

tcatactcat gaggggtaca tgatggattt gacagcccat cagggccggg ttggtaatat     1860

tctacaattg ggaagtaagc tgattggaac aggaaaatta tcagaagatg aagaaactga     1920

agtacaagag cagatgaatc tcctaaattc aagatgggaa tgcctcaggg tagctagcat     1980

ggaaaaacaa agcaatttac atagagtttt aatggatctc cagaatcaga aactgaaaga     2040

gttgaatgac tggctaacaa aaacagaaga aagaacaagg aaaatggagg aagagcctct     2100

tggacctgat cttgaagacc taaaacgcca agtacaacaa cataaggtgc ttcaagaaga     2160

tctagaacaa gaacaagtca gggtcaattc tctcactcac atggtggtgg tagttgatga     2220

atctagtgga gatcacgcaa ctgctgcttt ggaagaacaa cttaaggtat tgggagatcg     2280

atgggcaaac atctgtagat ggacagaaga ccgctgggtt cttttacaag acatccttct     2340

caaatggcaa cgtcttactg aagaacagtg cctttttagt gcatggcttt cagaaaaaga     2400

agatgcagtg aacaagattc acacaactgg ctttaaagat caaaatgaaa tgttatcaag     2460

tcttcaaaaa ctggccgttt taaaagcgga tctagaaaag aaaaagcaat ccatgggcaa     2520

actgtattca ctcaaacaag atcttctttc aacactgaag aataagtcag tgacccagaa     2580

gacggaagca tggctggata actttgcccg gtgttgggat aatttagtcc aaaaacttga     2640

aaagagtaca gcacagattt cacaggaaat ttcttatgtg ccttctactt atttgactga     2700

aatcactcat gtctcacaag ccctattaga agtggaacaa cttctcaatg ctcctgacct     2760

ctgtgctaag gactttgaag atctctttaa gcaagaggag tctctgaaga atataaaaga     2820

tagtctacaa caaagctcag gtcggattga cattattcat agcaagaaga cagcagcatt     2880

gcaaagtgca acgcctgtgg aaagggtgaa gctacaggaa gctctctccc agcttgattt     2940

ccaatgggaa aaagttaaca aaatgtacaa ggaccgacaa gggcgatttg acagatctgt     3000

tgagaaatgg cggcgttttc attatgatat aaagatattt aatcagtggc taacagaagc     3060

tgaacagttt ctcagaaaga cacaaattcc tgagaattgg gaacatgcta aatacaaatg     3120

gtatcttaag gaactccagg atggcattgg gcagcggcaa actgttgtca gaacattgaa     3180

tgcaactggg gaagaaataa ttcagcaatc ctcaaaaaca gatgccagta ttctacagga     3240

aaaattggga agcctgaatc tgcggtggca ggaggtctgc aaacagctgt cagacagaaa     3300

aaagaggcta gaagaacaaa agaatatctt gtcagaattt caaagagatt taaatgaatt     3360

tgttttatgg ttggaggaag cagataacat tgctagtatc ccacttgaac ctggaaaaga     3420

gcagcaacta aaagaaaagc ttgagcaagt caagttactg gtggaagagt tgcccctgcg     3480

ccagggaatt ctcaaacaat taaatgaaac tggaggaccc gtgcttgtaa gtgctcccat     3540

aagcccagaa gagcaagata aacttgaaaa taagctcaag cagacaaatc tccagtggat     3600

aaaggtttcc agagctttac ctgagaaaca aggagaaatt gaagctcaaa taaaagacct     3660

tgggcagctt gaaaaaaagc ttgaagacct tgaagagcag ttaaatcatc tgctgctgtg     3720

gttatctcct attaggaatc agttggaaat ttataaccaa ccaaaccaag aaggaccatt     3780

tgacgttcag gaaactgaaa tagcagttca agctaaacaa ccggatgtgg aagagatttt     3840

gtctaaaggg cagcatttgt acaaggaaaa accagccact cagccagtga agaggaagtt     3900

agaagatctg agctctgagt ggaaggcggt aaaccgttta cttcaagagc tgagggcaaa     3960

gcagcctgac ctagctcctg gactgaccac tattggagcc tctcctactc agactgttac     4020

tctggtgaca caacctgtgg ttactaagga aactgccatc tccaaactag aaatgccatc     4080

ttccttgatg ttggaggtac ctgctctggc agatttcaac cgggcttgga cagaacttac     4140

cgactggctt tctctgcttg atcaagttat aaaatcacag agggtgatgg tgggtgacct     4200

tgaggatatc aacgagatga tcatcaagca gaaggcaaca atgcaggatt tggaacagag     4260

gcgtccccag ttggaagaac tcattaccgc tgcccaaaat ttgaaaaaca agaccagcaa     4320

tcaagaggct agaacaatca ttacggatcg aattgaaaga attcagaatc agtgggatga     4380

agtacaagaa caccttcaga accggcgcca acagttgaat gaaatgttaa aggattcaac     4440

acaatggctg gaagctaagg aagaatttac gcgttttgcg gccgctttac gtagataagt     4500

agcatggcgg gttaatcatt aactacaagg aacccctagt gatggagttg gccactccct     4560

ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct     4620

ttgcccgggc ggcctcagtg agcgagcgag cgcgc                                4655


<210> 19
<211> 4262
<212> DNA
<213> Artificial Sequence


<220> 
<223> DD 3'AAV

<400> 19
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta tttgcggccg      180

ctttacgcgt ttttggaggt acctgctctg gcagatttca accgggcttg gacagaactt      240

accgactggc tttctctgct tgatcaagtt ataaaatcac agagggtgat ggtgggtgac      300

cttgaggata tcaacgagat gatcatcaag cagaaggcaa caatgcagga tttggaacag      360

aggcgtcccc agttggaaga actcattacc gctgcccaaa atttgaaaaa caagaccagc      420

aatcaagagg ctagaacaat cattacggat cgaattgaaa gaattcagaa tcagtgggat      480

gaagtacaag aacaccttca gaaccggcgc caacagttga atgaaatgtt aaaggattca      540

acacaatggc tggaagctaa ggaagaagct gagcaggtct taggacaggc cagagccaag      600

cttgagtcat ggaaggaggg tccctataca gtagatgcaa tccaaaagaa aatcacagaa      660

accaagcagt tggccaaaga cctccgccag tggcagacaa atgtagatgt ggcaaatgac      720

ttggccctga aacttctccg ggattattct gcagatgata ccagaaaagt ccacatgata      780

acagagaata tcaatgcctc ttggagaagc attcataaaa gggtgagtga gcgagaggct      840

gctttggaag aaactcatag attactgcaa cagttccccc tggacctgga aaagtttctt      900

gcctggctta cagaagctga aacaactgcc aatgtcctac aggatgctac ccgtaaggaa      960

aggctcctag aagactccaa gggagtaaaa gagctgatga aacaatggca agacctccaa     1020

ggtgaaattg aagctcacac agatgtttat cacaacctgg atgaaaacag ccaaaaaatc     1080

ctgagatccc tggaaggttc cgatgatgca gtcctgttac aaagacgttt ggataacatg     1140

aacttcaagt ggagtgaact tcggaaaaag tctctcaaca ttaggtccca tttggaagcc     1200

agttctgacc agtggaagcg tctgcacctt tctctgcagg aacttctggt gtggctacag     1260

ctgaaagatg atgaattaag ccggcaggca cctattggag gcgactttcc agcagttcag     1320

aagcagaacg atgtacatag ggccttcaag agggaattga aaactaaaga acctgtaatc     1380

atgagtactc ttgagactgt acgaatattt ctgacagagc agcctttgga aggactagag     1440

aaactctacc aggagcccag agagctgcct cctgaggaga gagcccagaa tgtcactcgg     1500

cttctacgaa agcaggctga ggaggtcaat actgagtggg aaaaattgaa cctgcactcc     1560

gctgactggc agagaaaaat agatgagacc cttgaaagac tccaggaact tcaagaggcc     1620

acggatgagc tggacctcaa gctgcgccaa gctgaggtga tcaagggatc ctggcagccc     1680

gtgggcgatc tcctcattga ctctctccaa gatcacctcg agaaagtcaa ggcacttcga     1740

ggagaaattg cgcctctgaa agagaacgtg agccacgtca atgaccttgc tcgccagctt     1800

accactttgg gcattcagct ctcaccgtat aacctcagca ctctggaaga cctgaacacc     1860

agatggaagc ttctgcaggt ggccgtcgag gaccgagtca ggcagctgca tgaagcccac     1920

agggactttg gtccagcatc tcagcacttt ctttccacgt ctgtccaggg tccctgggag     1980

agagccatct cgccaaacaa agtgccctac tatatcaacc acgagactca aacaacttgc     2040

tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga     2100

ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat     2160

ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac     2220

cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag     2280

caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg     2340

ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc     2400

atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg     2460

gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc     2520

caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt     2580

gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta     2640

gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct     2700

gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt     2760

ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt     2820

tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg     2880

actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc     2940

aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag     3000

ggggacaaca tggaaactcc cgttactctg atcaacttct ggccagtaga ttctgcgcct     3060

gcctcgtccc ctcagctttc acacgatgat actcattcac gcattgaaca ttatgctagc     3120

aggctagcag aaatggaaaa cagcaatgga tcttatctaa atgatagcat ctctcctaat     3180

gagagcatag atgatgaaca tttgttaatc cagcattact gccaaagttt gaaccaggac     3240

tcccccctga gccagcctcg tagtcctgcc cagatcttga tttccttaga gagtgaggaa     3300

agaggggagc tagagagaat cctagcagat cttgaggaag aaaacaggaa tctgcaagca     3360

gaatatgacc gtctaaagca gcagcacgaa cataaaggcc tgtccccact gccgtcccct     3420

cctgaaatga tgcccacctc tccccagagt ccccgggatg ctgagctcat tgctgaggcc     3480

aagctactgc gtcaacacaa aggccgcctg gaagccagga tgcaaatcct ggaagaccac     3540

aataaacagc tggagtcaca gttacacagg ctaaggcagc tgctggagca accccaggca     3600

gaggccaaag tgaatggcac aacggtgtcc tctccttcta cctctctaca gaggtccgac     3660

agcagtcagc ctatgctgct ccgagtggtt ggcagtcaaa cttcggactc catgggtgag     3720

gaagatcttc tcagtcctcc ccaggacaca agcacagggt tagaggaggt gatggagcaa     3780

ctcaacaact ccttccctag ttcaagagga agaaataccc ctggaaagcc aatgagagag     3840

gacacaatgt agcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa     3900

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca     3960

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc     4020

agggggagat gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtattgtcg     4080

actttactag tttttacgta gataagtagc atggcgggtt aatcattaac tacaaggaac     4140

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     4200

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     4260

gc                                                                    4262


<210> 20
<211> 2427
<212> PRT
<213> Artificial Sequence


<220> 
<223> WL1 OPT codée

<400> 20
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      
Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          
Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              
Ser Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  
Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 
Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     
Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         
His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             
Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 
Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 
His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     
Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         
Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             
Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 
Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 
Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     
Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         
Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             
Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 
Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 
Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     
Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         
Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             
Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 
Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 
Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     
Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         
Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             
Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 
Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 
Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     
Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         
Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             
Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 
Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Gly Leu Glu 
705                 710                 715                 720 
Lys Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 
                725                 730                 735     
Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Ser Glu Tyr Lys Thr 
            740                 745                 750         
Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala Lys Glu 
        755                 760                 765             
Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr Glu Ser Val 
    770                 775                 780                 
Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln Glu Ala Leu Lys 
785                 790                 795                 800 
Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln Trp Leu Cys Thr Arg 
                805                 810                 815     
Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu Val Trp Ala Cys Trp His 
            820                 825                 830         
Glu Leu Leu Ser Tyr Leu Glu Lys Ala Asn Lys Trp Leu Asn Glu Val 
        835                 840                 845             
Glu Phe Lys Leu Lys Thr Thr Glu Asn Ile Pro Gly Gly Ala Glu Glu 
    850                 855                 860                 
Ile Ser Glu Val Leu Asp Ser Leu Glu Asn Leu Met Arg His Ser Glu 
865                 870                 875                 880 
Asp Asn Pro Asn Gln Ile Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly 
                885                 890                 895     
Gly Val Met Asp Glu Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser 
            900                 905                 910         
Arg Trp Arg Glu Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu 
        915                 920                 925             
Glu Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu 
    930                 935                 940                 
Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu 
945                 950                 955                 960 
Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn 
                965                 970                 975     
Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu 
            980                 985                 990         
Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg 
        995                 1000                1005            
Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr 
    1010                1015                1020                
Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe 
1025                1030                1035                1040
Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe 
                1045                1050                1055    
Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile 
            1060                1065                1070        
Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln 
        1075                1080                1085            
Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu 
    1090                1095                1100                
Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 
1105                1110                1115                1120
Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser 
                1125                1130                1135    
Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val 
            1140                1145                1150        
Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Pro Asp 
        1155                1160                1165            
Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val 
    1170                1175                1180                
Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys 
1185                1190                1195                1200
Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp 
                1205                1210                1215    
Phe Asn Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp 
            1220                1225                1230        
Gln Val Ile Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile 
        1235                1240                1245            
Asn Glu Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln 
    1250                1255                1260                
Arg Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys 
1265                1270                1275                1280
Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile 
                1285                1290                1295    
Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn 
            1300                1305                1310        
Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln Trp Leu 
        1315                1320                1325            
Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys 
    1330                1335                1340                
Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys 
1345                1350                1355                1360
Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln 
                1365                1370                1375    
Thr Asn Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp 
            1380                1385                1390        
Tyr Ser Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile 
        1395                1400                1405            
Asn Ala Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu Ala 
    1410                1415                1420                
Ala Leu Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu 
1425                1430                1435                1440
Glu Lys Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val 
                1445                1450                1455    
Leu Gln Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly 
            1460                1465                1470        
Val Lys Glu Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu 
        1475                1480                1485            
Ala His Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile 
    1490                1495                1500                
Leu Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg 
1505                1510                1515                1520
Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu 
                1525                1530                1535    
Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu 
            1540                1545                1550        
His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp 
        1555                1560                1565            
Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln 
    1570                1575                1580                
Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys 
1585                1590                1595                1600
Glu Pro Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr 
                1605                1610                1615    
Glu Gln Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu 
            1620                1625                1630        
Leu Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys 
        1635                1640                1645            
Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser 
    1650                1655                1660                
Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu 
1665                1670                1675                1680
Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu 
                1685                1690                1695    
Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser 
            1700                1705                1710        
Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala 
        1715                1720                1725            
Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu 
    1730                1735                1740                
Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 
1745                1750                1755                1760
Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg 
                1765                1770                1775    
Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln 
            1780                1785                1790        
His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser 
        1795                1800                1805            
Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys 
    1810                1815                1820                
Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu 
1825                1830                1835                1840
Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg 
                1845                1850                1855    
Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys 
            1860                1865                1870        
Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp 
        1875                1880                1885            
Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu 
    1890                1895                1900                
Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys 
1905                1910                1915                1920
Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile 
                1925                1930                1935    
Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His 
            1940                1945                1950        
Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr 
        1955                1960                1965            
Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile 
    1970                1975                1980                
Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn 
1985                1990                1995                2000
Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro 
                2005                2010                2015    
Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln 
            2020                2025                2030        
Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr 
        2035                2040                2045            
Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile 
    2050                2055                2060                
Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln 
2065                2070                2075                2080
Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr 
                2085                2090                2095    
Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg 
            2100                2105                2110        
Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe 
        2115                2120                2125            
Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu 
    2130                2135                2140                
Gly Asp Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val 
2145                2150                2155                2160
Asp Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His 
                2165                2170                2175    
Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser 
            2180                2185                2190        
Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp 
        2195                2200                2205            
Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp 
    2210                2215                2220                
Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu 
2225                2230                2235                2240
Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu 
                2245                2250                2255    
Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln 
            2260                2265                2270        
His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met 
        2275                2280                2285            
Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala 
    2290                2295                2300                
Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile 
2305                2310                2315                2320
Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg 
                2325                2330                2335    
Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr 
            2340                2345                2350        
Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro 
        2355                2360                2365            
Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu 
    2370                2375                2380                
Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu 
2385                2390                2395                2400
Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn 
                2405                2410                2415    
Thr Pro Gly Lys Pro Met Arg Glu Asp Thr Met 
            2420                2425        

<210> 21
<211> 7221
<212> DNA
<213> artificial sequence


<220> 
<223> WL2 wt

<400> 21
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaaatgt tgccaaggcc acctaaagtg      780

actaaagaag aacattttca gttacatcat caaatgcact attctcaaca gatcacggtc      840

agtctagcac agggatatga gagaacttct tcccctaagc ctcgattcaa gagctatgcc      900

tacacacagg ctgcttatgt caccacctct gaccctacac ggagcccatt tccttcacag      960

catttggaag ctcctgaaga caagtcattt ggcagttcat tgatggagag tgaagtaaac     1020

ctggaccgtt atcaaacagc tttagaagaa gtattatcgt ggcttctttc tgctgaggac     1080

acattgcaag cacaaggaga gatttctaat gatgtggaag tggtgaaaga ccagtttcat     1140

actcatgagg ggtacatgat ggatttgaca gcccatcagg gccgggttgg taatattcta     1200

caattgggaa gtaagctgat tggaacagga aaattatcag aagatgaaga aactgaagta     1260

caagagcaga tgaatctcct aaattcaaga tgggaatgcc tcagggtagc tagcatggaa     1320

aaacaaagca atttacatag agttttaatg gatctccaga atcagaaact gaaagagttg     1380

aatgactggc taacaaaaac agaagaaaga acaaggaaaa tggaggaaga gcctcttgga     1440

cctgatcttg aagacctaaa acgccaagta caacaacata aggtgcttca agaagatcta     1500

gaacaagaac aagtcagggt caattctctc actcacatgg tggtggtagt tgatgaatct     1560

agtggagatc acgcaactgc tgctttggaa gaacaactta aggtattggg agatcgatgg     1620

gcaaacatct gtagatggac agaagaccgc tgggttcttt tacaagacat ccttctcaaa     1680

tggcaacgtc ttactgaaga acagtgcctt tttagtgcat ggctttcaga aaaagaagat     1740

gcagtgaaca agattcacac aactggcttt aaagatcaaa atgaaatgtt atcaagtctt     1800

caaaaactgg ccgttttaaa agcggatcta gaaaagaaaa agcaatccat gggcaaactg     1860

tattcactca aacaagatct tctttcaaca ctgaagaata agtcagtgac ccagaagacg     1920

gaagcatggc tggataactt tgcccggtgt tgggataatt tagtccaaaa acttgaaaag     1980

agtacagcac agatttcaca ggctgtcacc accactcagc catcactaac acagacaact     2040

gtaatggaaa cagtaactac ggtgaccaca agggaacaga tcctggtaaa gcatgctcaa     2100

gaggaacttc caccaccacc tccccaaaag aagaggcaga ttactgtgga tggtttggag     2160

aaaactgtaa gcctccagaa agatctatca gagatgcacg aatggatgac acaagctgaa     2220

gaagagtatc ttgagagaga ttttgaatat aaaactccag atgaattaca gaaagcagtt     2280

gaagagatga agagagctaa agaagaggcc caacaaaaag aagcgaaagt gaaactcctt     2340

actgagtctg taaatagtgt catagctcaa gctccacctg tagcacaaga ggccttaaaa     2400

aaggaacttg aaactctaac caccaactac cagtggctct gcactaggct gaatgggaaa     2460

tgcaagactt tggaagaagt ttgggcatgt tggcatgagt tattgtcata cttggagaaa     2520

gcaaacaagt ggctaaatga agtagaattt aaacttaaaa ccactgaaaa cattcctggc     2580

ggagctgagg aaatctctga ggtgctagat tcacttgaaa atttgatgcg acattcagag     2640

gataacccaa atcagattcg catattggca cagaccctaa cagatggcgg agtcatggat     2700

gagctaatca atgaggaact tgagacattt aattctcgtt ggagggaact acatgaagag     2760

gctgtaagga ggcaaaagtt gcttgaacag cctttgaagg aattggagca gtttaactca     2820

gatatacaaa aattgcttga accactggag gctgaaattc agcagggggt gaatctgaaa     2880

gaggaagact tcaataaaga tatgaatgaa gacaatgagg gtactgtaaa agaattgttg     2940

caaagaggag acaacttaca acaaagaatc acagatgaga gaaagagaga ggaaataaag     3000

ataaaacagc agctgttaca gacaaaacat aacgcgttca aggatttgag gtctcaaaga     3060

agaaaaaagg ctctagaaat ttctcatcag tggtatcagt acaagaggca ggctgatgat     3120

ctcctgaaat gcttggatga cattgaaaaa aaattagcca gcctacctga gcccagagat     3180

gaaaggaaaa taaaggaaat tgatcgggaa ttgcagaaga agaaagagga gctgaatgca     3240

gtgcgtaggc aagctgaggg cttgtctgag gatggggccg caatggcagt ggagccaact     3300

cagatccagc tcagcaagcg ctggcgggaa attgagagca aatttgctca gtttcgaaga     3360

ctcaactttg cacaaattca cactgtccgt gaagaaacga tgatggtgat gactgaagac     3420

atgcctttgg aaatttctta tgtgccttct acttatttga ctgaaatcac tcatgtctca     3480

caagccctat tagaagtgga acaacttctc aatgctcctg acctctgtgc taaggacttt     3540

gaagatctct ttaagcaaga ggagtctctg aagaatataa aagatagtct acaacaaagc     3600

tcaggtcgga ttgacattat tcatagcaag aagacagcag cattgcaaag tgcaacgcct     3660

gtggaaaggg tgaagctaca ggaagctctc tcccagcttg atttccaatg ggaaaaagtt     3720

aacaaaatgt acaaggaccg acaagggcga tttgacagat ctgttgagaa atggcggcgt     3780

tttcattatg atataaagat atttaatcag tggctaacag aagctgaaca gtttctcaga     3840

aagacacaaa ttcctgagaa ttgggaacat gctaaataca aatggtatct taaggaactc     3900

caggatggca ttgggcagcg gcaaactgtt gtcagaacat tgaatgcaac tggggaagaa     3960

ataattcagc aatcctcaaa aacagatgcc agtattctac aggaaaaatt gggaagcctg     4020

aatctgcggt ggcaggaggt ctgcaaacag ctgtcagaca gaaaaaagag gctagaagag     4080

cagcctgacc tagctcctgg actgaccact attggagcct ctcctactca gactgttact     4140

ctggtgacac aacctgtggt tactaaggaa actgccatct ccaaactaga aatgccatct     4200

tccttgatgt tggaggtacc aactcataga ttactgcaac agttccccct ggacctggaa     4260

aagtttcttg cctggcttac agaagctgaa acaactgcca atgtcctaca ggatgctacc     4320

cgtaaggaaa ggctcctaga agactccaag ggagtaaaag agctgatgaa acaatggcaa     4380

gacctccaag gtgaaattga agctcacaca gatgtttatc acaacctgga tgaaaacagc     4440

caaaaaatcc tgagatccct ggaaggttcc gatgatgcag tcctgttaca aagacgtttg     4500

gataacatga acttcaagtg gagtgaactt cggaaaaagt ctctcaacat taggtcccat     4560

ttggaagcca gttctgacca gtggaagcgt ctgcaccttt ctctgcagga acttctggtg     4620

tggctacagc tgaaagatga tgaattaagc cggcaggcac ctattggagg cgactttcca     4680

gcagttcaga agcagaacga tgtacatagg gccttcaaga gggaattgaa aactaaagaa     4740

cctgtaatca tgagtactct tgagactgta cgaatatttc tgacagagca gcctttggaa     4800

ggactagaga aactctacca ggagcccaga gagctgcctc ctgaggagag agcccagaat     4860

gtcactcggc ttctacgaaa gcaggctgag gaggtcaata ctgagtggga aaaattgaac     4920

ctgcactccg ctgactggca gagaaaaata gatgagaccc ttgaaagact ccaggaactt     4980

caagaggcca cggatgagct ggacctcaag ctgcgccaag ctgaggtgat caagggatcc     5040

tggcagcccg tgggcgatct cctcattgac tctctccaag atcacctcga gaaagtcaag     5100

gcacttcgag gagaaattgc gcctctgaaa gagaacgtga gccacgtcaa tgaccttgct     5160

cgccagctta ccactttggg cattcagctc tcaccgtata acctcagcac tctggaagac     5220

ctgaacacca gatggaagct tctgcaggtg gccgtcgagg accgagtcag gcagctgcat     5280

gaagcccaca gggactttgg tccagcatct cagcactttc tttccacgtc tgtccagggt     5340

ccctgggaga gagccatctc gccaaacaaa gtgccctact atatcaacca cgagactcaa     5400

acaacttgct gggaccatcc caaaatgaca gagctctacc agtctttagc tgacctgaat     5460

aatgtcagat tctcagctta taggactgcc atgaaactcc gaagactgca gaaggccctt     5520

tgcttggatc tcttgagcct gtcagctgca tgtgatgcct tggaccagca caacctcaag     5580

caaaatgacc agcccatgga tatcctgcag attattaatt gtttgaccac tatttatgac     5640

cgcctggagc aagagcacaa caatttggtc aacgtccctc tctgcgtgga tatgtgtctg     5700

aactggctgc tgaatgttta tgatacggga cgaacaggga ggatccgtgt cctgtctttt     5760

aaaactggca tcatttccct gtgtaaagca catttggaag acaagtacag ataccttttc     5820

aagcaagtgg caagttcaac aggattttgt gaccagcgca ggctgggcct ccttctgcat     5880

gattctatcc aaattccaag acagttgggt gaagttgcat cctttggggg cagtaacatt     5940

gagccaagtg tccggagctg cttccaattt gctaataata agccagagat cgaagcggcc     6000

ctcttcctag actggatgag actggaaccc cagtccatgg tgtggctgcc cgtcctgcac     6060

agagtggctg ctgcagaaac tgccaagcat caggccaaat gtaacatctg caaagagtgt     6120

ccaatcattg gattcaggta caggagtcta aagcacttta attatgacat ctgccaaagc     6180

tgcttttttt ctggtcgagt tgcaaaaggc cataaaatgc actatcccat ggtggaatat     6240

tgcactccga ctacatcagg agaagatgtt cgagactttg ccaaggtact aaaaaacaaa     6300

tttcgaacca aaaggtattt tgcgaagcat ccccgaatgg gctacctgcc agtgcagact     6360

gtcttagagg gggacaacat ggaaactccc gttactctga tcaacttctg gccagtagat     6420

tctgcgcctg cctcgtcccc tcagctttca cacgatgata ctcattcacg cattgaacat     6480

tatgctagca ggctagcaga aatggaaaac agcaatggat cttatctaaa tgatagcatc     6540

tctcctaatg agagcataga tgatgaacat ttgttaatcc agcattactg ccaaagtttg     6600

aaccaggact cccccctgag ccagcctcgt agtcctgccc agatcttgat ttccttagag     6660

agtgaggaaa gaggggagct agagagaatc ctagcagatc ttgaggaaga aaacaggaat     6720

ctgcaagcag aatatgaccg tctaaagcag cagcacgaac ataaaggcct gtccccactg     6780

ccgtcccctc ctgaaatgat gcccacctct ccccagagtc cccgggatgc tgagctcatt     6840

gctgaggcca agctactgcg tcaacacaaa ggccgcctgg aagccaggat gcaaatcctg     6900

gaagaccaca ataaacagct ggagtcacag ttacacaggc taaggcagct gctggagcaa     6960

ccccaggcag aggccaaagt gaatggcaca acggtgtcct ctccttctac ctctctacag     7020

aggtccgaca gcagtcagcc tatgctgctc cgagtggttg gcagtcaaac ttcggactcc     7080

atgggtgagg aagatcttct cagtcctccc caggacacaa gcacagggtt agaggaggtg     7140

atggagcaac tcaacaactc cttccctagt tcaagaggaa gaaatacccc tggaaagcca     7200

atgagagagg acacaatgta g                                               7221


<210> 22
<211> 7284
<212> DNA
<213> Artificial Sequence


<220> 
<223> WL1 cor

<400> 22
atgctgtggt gggaggaggt ggaggactgc tatgagagag aggatgtgca gaagaagacc       60

ttcaccaagt gggtgaatgc ccagttcagc aagtttggca agcagcacat tgagaacctg      120

ttctctgacc tgcaggatgg caggaggctg ctggacctgc tggagggcct aacaggccag      180

aagctgccca aggagaaggg cagtaccagg gtgcatgccc tgaacaatgt gaacaaggcc      240

ctgagggtgc tgcagaacaa caatgtggac ctagtgaata ttggcagtac agatattgtg      300

gatggcaacc acaagctgac cctgggcctg atctggaata ttatcctaca ctggcaggtg      360

aagaatgtga tgaagaatat tatggctggc ctgcagcaga ccaactctga gaagatcctg      420

ctgagctggg tgaggcagag taccaggaac tacccccagg tgaatgtgat caacttcacc      480

accagctggt ctgatggcct ggccctgaat gccctaatcc acagccacag gcctgacctg      540

tttgactgga actctgtggt gtgccagcag tctgccaccc agaggctaga gcatgccttc      600

aatattgcca ggtaccagct ggggattgag aagctgctgg accctgagga tgtggataca      660

acctaccctg acaagaagag catcctgatg tacatcacca gcctgttcca ggtgctgccc      720

cagcaggtga gcattgaggc catccaggag gtggagatgc tacccaggcc ccccaaggtg      780

accaaggagg agcacttcca gctacaccac cagatgcact acagccagca gatcacagtg      840

agcctggccc agggctatga gaggaccagc agccccaagc ccaggttcaa gagctatgcc      900

tacacccagg ctgcctatgt gaccacctca gaccccacca ggagcccctt ccccagccag      960

cacctggagg cccctgagga caagagcttt ggcagcagcc tgatggagtc tgaggtgaac     1020

ctggacaggt accagacagc cctggaggag gtgctgagct ggctgctgtc tgctgaggat     1080

accctacagg cccagggaga gatcagcaat gatgtggagg tggtgaagga ccagttccat     1140

acccatgagg gctacatgat ggacctaaca gcccaccagg gcagggtggg caacatcctg     1200

cagctgggca gcaagctgat tggcacaggc aagctgtctg aggatgagga gacagaggtg     1260

caggagcaga tgaacctgct gaacagcagg tgggagtgcc tgagggtggc cagtatggag     1320

aagcagagca acctacacag ggtgctgatg gacctgcaga accagaagct gaaggagctg     1380

aatgactggc tgaccaagac agaggagagg accaggaaga tggaggagga gcccctgggc     1440

cctgacctgg aggacctaaa gaggcaggtg cagcagcaca aggtgctgca ggaggacctg     1500

gagcaggagc aggtgagggt gaacagccta acccatatgg tggtggtggt ggatgagagc     1560

tcaggagacc atgctacagc tgccctggag gagcagctga aggtgctggg agacaggtgg     1620

gctaatatct gcaggtggac agaggacagg tgggtgctgc tgcaggatat cctgctgaag     1680

tggcagaggc tgacagagga gcagtgcctg ttctctgcct ggctgtcaga gaaggaggat     1740

gctgtgaaca agatccatac aacaggcttc aaggaccaga atgagatgct gagcagcctg     1800

cagaagctgg ctgtgctgaa ggctgacctg gagaagaaga agcagagtat gggcaagctg     1860

tacagcctga agcaggacct gctgagtacc ctgaagaaca agtctgtgac ccagaagaca     1920

gaggcctggc tggacaactt tgccaggtgc tgggataacc tggtgcagaa gctggagaag     1980

agtacagccc agatcagcca ggctgtgaca acaacccagc ccagcctgac ccagacaaca     2040

gtgatggaga cagtgacaac agtgacaacc agggagcaga tcctagtgaa gcatgcccag     2100

gaggagctgc cccccccccc cccccagaag aagaggcaga ttacagtgga tggcctggag     2160

aagacagtga gcctccagaa ggacctgtca gagatgcatg agtggatgac ccaggctgag     2220

gaggagtacc tggagaggga cttcgagtac aagacccctg atgagctgca gaaggctgtg     2280

gaggagatga agagggccaa ggaggaggcc cagcagaagg aggccaaggt gaagctgctg     2340

acagagtctg tgaactctgt gattgcccag gccccccctg tggcccagga ggccctgaag     2400

aaggagctgg agaccctgac aaccaactac cagtggctgt gcaccaggct gaatggcaag     2460

tgcaagaccc tagaggaggt gtgggcctgc tggcatgagc tgctgagcta cctggagaag     2520

gccaacaagt ggctgaatga ggtggagttc aagctgaaga ccacagagaa catccctgga     2580

ggagctgagg agatctctga ggtgctggac agcctggaga acctaatgag gcactctgag     2640

gacaacccca accagatcag gatcctggcc cagaccctga cagatggagg agtgatggat     2700

gagctgatca atgaggagct ggagaccttc aacagcaggt ggagggagct acatgaggag     2760

gctgtgagga ggcagaagct gctagagcag atccatacag tgagggagga gacaatgatg     2820

gtgatgacag aggatatgcc cctggagatc agctatgtgc ccagcaccta cctaacagag     2880

atcacccatg tgagccaggc cctgctggag gtggagcagc tgctgaatgc ccctgacctg     2940

tgtgccaagg actttgagga cctgttcaag caggaggaga gcctgaagaa catcaaggac     3000

agcctgcagc agagctcagg caggattgat attatccaca gcaagaagac agctgccctg     3060

cagtctgcta cccctgtgga gagggtgaag ctgcaggagg ccctgagcca gctggacttc     3120

cagtgggaga aggtgaacaa gatgtacaag gacaggcagg gcaggtttga caggtcagtg     3180

gagaagtgga ggaggttcca ctatgacatc aagatcttca accagtggct gacagaggct     3240

gagcagttcc taaggaagac ccagatccct gagaactggg agcatgccaa gtacaagtgg     3300

taccttaagg agctgcagga tggcattggc cagaggcaga cagtggtgag gaccctgaat     3360

gctacagggg aggagattat ccagcagagc agcaagacag atgccagtat cctgcaggag     3420

aagctgggca gcctgaacct gaggtggcag gaggtgtgca agcagctgtc tgacaggaag     3480

aagaggctgg aggagcagcc tgacctggcc cctggcctga caacaattgg agccagccct     3540

acccagacag tgaccctggt gacccagcct gtggtgacca aggagacagc tatcagcaag     3600

ctggagatgc ccagcagcct gatgctggag gtgcctgccc tggctgactt caacagggcc     3660

tggacagagc tgacagactg gctgagcctg ctggaccagg tgatcaagag ccagagggtg     3720

atggtggggg acctggagga tatcaatgag atgattatca agcagaaggc tacaatgcag     3780

gacctggagc agaggaggcc ccagctggag gagctgatta cagctgccca gaacctaaag     3840

aacaagacca gcaaccagga ggccaggaca attattacag acaggattga gaggatccag     3900

aaccagtggg atgaggtgca ggagcacctg cagaacagga ggcagcagct gaatgagatg     3960

ctgaaggaca gtacccagtg gctggaggcc aaggaggagg ctgagcaggt gctgggccag     4020

gccagggcca agctggagag ctggaaggag ggcccctaca cagtggatgc catccagaag     4080

aagatcacag agaccaagca gctggccaag gacctgaggc agtggcagac caatgtggat     4140

gtggccaatg acctggccct gaagctgctg agggactact cagctgatga caccaggaag     4200

gtgcacatga tcacagagaa catcaatgcc agctggagga gcatccacaa gagggtgtct     4260

gagagggagg ctgccctaga ggagacccac aggctgctgc agcagttccc cctggacctg     4320

gagaagttcc tggcctggct gacagaggct gagacaacag ccaatgtgct gcaggatgct     4380

accaggaagg agaggctgct ggaggacagc aagggagtga aggagctgat gaagcagtgg     4440

caggacctac agggggagat tgaggcccat acagatgtgt accacaacct ggatgagaac     4500

agccagaaga tcctgaggag cctggagggc tctgatgatg ctgtgctgct gcagaggagg     4560

ctggacaata tgaacttcaa gtggtctgag ctgaggaaga agagcctaaa tatcaggagc     4620

cacctggagg ccagctctga ccagtggaag aggctacacc tgagcctgca ggagctgctg     4680

gtgtggctgc agctgaagga tgatgagcta agcaggcagg cccctattgg gggagacttc     4740

cctgctgtgc agaagcagaa tgatgtgcac agggccttca agagggagct gaagaccaag     4800

gagcctgtga ttatgagtac cctggagaca gtgaggatct tcctgacaga gcagcccctg     4860

gagggcctgg agaagctgta ccaggagccc agggagctgc cccctgagga gagggcccag     4920

aatgtgacca ggctgctgag gaagcaggct gaggaggtga atacagagtg ggagaagctg     4980

aacctacact ctgctgactg gcagaggaag attgatgaga ccctggagag gctgcaggag     5040

ctgcaggagg ctacagatga gctggacctg aagctgaggc aggctgaggt gatcaagggc     5100

agctggcagc ctgtggggga cctgctgatt gacagcctac aggaccacct ggagaaggtg     5160

aaggccctga ggggagagat tgccccccta aaggagaatg tgagtcatgt gaatgacctg     5220

gccaggcagc tgaccaccct gggcatccag ctgagcccct acaacctgag caccctggag     5280

gacctgaaca ccaggtggaa gctgctgcag gtggctgtgg aggacagggt gaggcagcta     5340

catgaggccc acagggactt tggccctgcc agccagcact tcctaagcac ctctgttcag     5400

ggcccctggg agagggccat cagccccaac aaggtgccct actacatcaa ccatgagacc     5460

cagaccacct gctgggacca ccccaagatg acagagctgt accagagcct ggctgacctg     5520

aacaatgtga ggttctctgc ctacaggaca gccatgaagc tgaggaggct gcagaaggcc     5580

ctgtgcctgg acctgctgag cctgtctgct gcctgtgatg ccctagacca gcacaacctg     5640

aagcagaatg accagcccat ggacatcctt cagatcatca actgcctgac caccatctat     5700

gacaggctag agcaggagca caacaacctg gtgaatgtgc ccctgtgtgt ggacatgtgc     5760

ctgaactggc tgctgaatgt gtatgacaca ggcaggacag gcaggatcag ggtgctgagc     5820

ttcaagacag gcatcatcag cctatgcaag gctcacctgg aggacaagta caggtacctg     5880

ttcaagcagg tggccagcag cacaggcttc tgtgaccaga ggaggctggg cctgctactt     5940

catgacagca ttcagatccc caggcagctg ggagaggtgg ccagctttgg aggcagcaac     6000

attgagccct cagtgaggag ctgcttccag tttgccaaca acaagcctga gattgaggct     6060

gccctgttcc tggactggat gaggctggag cctcagagca tggtgtggct gcctgtgctg     6120

cacagggtgg ctgctgctga gacagccaag catcaggcca agtgcaacat ctgcaaggag     6180

tgccccatca ttggcttcag gtacaggagc ctaaagcact tcaactatga catctgccag     6240

agctgcttct tctcaggcag ggtggccaag ggccacaaga tgcactaccc catggtggag     6300

tactgcaccc ccaccacctc aggagaggat gtgagggact ttgccaaggt gctgaagaac     6360

aagttcagga ccaagaggta ctttgccaag caccccagga tgggctacct gcctgtgcag     6420

acagtgctgg agggggacaa catggagacc cctgtgaccc tgatcaactt ctggcctgtg     6480

gactcagccc ctgccagcag cccccagctg agccatgatg acacccacag caggattgag     6540

cactatgcca gcaggctggc tgagatggag aacagcaatg gcagctacct aaatgacagc     6600

atcagcccca atgagagcat tgatgatgag cacctgctaa tccagcacta ctgccagagc     6660

ctgaaccagg acagccccct gagccagccc aggagccctg cccagatcct gatcagcctg     6720

gagtctgagg agagggggga gctggagagg atcctggctg acctggagga ggagaacagg     6780

aaccttcagg ctgagtatga caggctaaag cagcagcatg agcacaaggg cctgagcccc     6840

ctacccagcc cccctgagat gatgcccacc agcccccaga gccccaggga tgctgagctg     6900

attgctgagg ccaagctgct gaggcagcac aagggcaggc tggaggccag gatgcagatc     6960

ctagaggacc acaacaagca gctggagagc cagctacaca ggctgaggca gctgctggag     7020

cagcctcagg ctgaggccaa ggtgaatggc accacagtga gcagccccag caccagcctg     7080

cagaggtctg acagcagtca gcccatgctg ctcagggtgg tgggcagtca gacctctgac     7140

agcatgggag aggaggacct gctgagcccc cctcaggaca ccagcacagg cctggaggag     7200

gtgatggagc agctgaacaa cagcttcccc agcagcaggg gcaggaacac ccctggcaag     7260

cccatgaggg aggacaccat gtag                                            7284


<210> 23
<211> 4768
<212> DNA
<213> Artificial Sequence


<220> 
<223> 5' WL1 cor

<400> 23
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta ttggccgtcc      180

gccctcggca ccatcctcac gacacccaaa tatggcgacg ggtgaggaat ggtggggagt      240

tatttttaga gcggtgagga aggtgggcag gcagcaggtg ttggcgctct aaaaataact      300

cccgggagtt atttttagag cggaggaatg gtggacaccc aaatatggcg acggttcctc      360

acccgtcgcc atatttgggt gtccgccctc ggccggggcc gcattcctgg gggccgggcg      420

gtgctcccgc ccgcctcgat aaaaggctcc ggggccggcg gcggcccacg agctacccgg      480

aggagcggga ggcgccaagc tctagagtaa gtatcaaggt tacaagacag gtttaaggag      540

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta      600

ttggtcttac tgacatccac tttgcctttc tctccacagg ccaccatgct gtggtgggag      660

gaggtggagg actgctatga gagagaggat gtgcagaaga agaccttcac caagtgggtg      720

aatgcccagt tcagcaagtt tggcaagcag cacattgaga acctgttctc tgacctgcag      780

gatggcagga ggctgctgga cctgctggag ggcctaacag gccagaagct gcccaaggag      840

aagggcagta ccagggtgca tgccctgaac aatgtgaaca aggccctgag ggtgctgcag      900

aacaacaatg tggacctagt gaatattggc agtacagata ttgtggatgg caaccacaag      960

ctgaccctgg gcctgatctg gaatattatc ctacactggc aggtgaagaa tgtgatgaag     1020

aatattatgg ctggcctgca gcagaccaac tctgagaaga tcctgctgag ctgggtgagg     1080

cagagtacca ggaactaccc ccaggtgaat gtgatcaact tcaccaccag ctggtctgat     1140

ggcctggccc tgaatgccct aatccacagc cacaggcctg acctgtttga ctggaactct     1200

gtggtgtgcc agcagtctgc cacccagagg ctagagcatg ccttcaatat tgccaggtac     1260

cagctgggga ttgagaagct gctggaccct gaggatgtgg atacaaccta ccctgacaag     1320

aagagcatcc tgatgtacat caccagcctg ttccaggtgc tgccccagca ggtgagcatt     1380

gaggccatcc aggaggtgga gatgctaccc aggcccccca aggtgaccaa ggaggagcac     1440

ttccagctac accaccagat gcactacagc cagcagatca cagtgagcct ggcccagggc     1500

tatgagagga ccagcagccc caagcccagg ttcaagagct atgcctacac ccaggctgcc     1560

tatgtgacca cctcagaccc caccaggagc cccttcccca gccagcacct ggaggcccct     1620

gaggacaaga gctttggcag cagcctgatg gagtctgagg tgaacctgga caggtaccag     1680

acagccctgg aggaggtgct gagctggctg ctgtctgctg aggataccct acaggcccag     1740

ggagagatca gcaatgatgt ggaggtggtg aaggaccagt tccataccca tgagggctac     1800

atgatggacc taacagccca ccagggcagg gtgggcaaca tcctgcagct gggcagcaag     1860

ctgattggca caggcaagct gtctgaggat gaggagacag aggtgcagga gcagatgaac     1920

ctgctgaaca gcaggtggga gtgcctgagg gtggccagta tggagaagca gagcaaccta     1980

cacagggtgc tgatggacct gcagaaccag aagctgaagg agctgaatga ctggctgacc     2040

aagacagagg agaggaccag gaagatggag gaggagcccc tgggccctga cctggaggac     2100

ctaaagaggc aggtgcagca gcacaaggtg ctgcaggagg acctggagca ggagcaggtg     2160

agggtgaaca gcctaaccca tatggtggtg gtggtggatg agagctcagg agaccatgct     2220

acagctgccc tggaggagca gctgaaggtg ctgggagaca ggtgggctaa tatctgcagg     2280

tggacagagg acaggtgggt gctgctgcag gatatcctgc tgaagtggca gaggctgaca     2340

gaggagcagt gcctgttctc tgcctggctg tcagagaagg aggatgctgt gaacaagatc     2400

catacaacag gcttcaagga ccagaatgag atgctgagca gcctgcagaa gctggctgtg     2460

ctgaaggctg acctggagaa gaagaagcag agtatgggca agctgtacag cctgaagcag     2520

gacctgctga gtaccctgaa gaacaagtct gtgacccaga agacagaggc ctggctggac     2580

aactttgcca ggtgctggga taacctggtg cagaagctgg agaagagtac agcccagatc     2640

agccaggctg tgacaacaac ccagcccagc ctgacccaga caacagtgat ggagacagtg     2700

acaacagtga caaccaggga gcagatccta gtgaagcatg cccaggagga gctgcccccc     2760

cccccccccc agaagaagag gcagattaca gtggatggcc tggagaagac agtgagcctc     2820

cagaaggacc tgtcagagat gcatgagtgg atgacccagg ctgaggagga gtacctggag     2880

agggacttcg agtacaagac ccctgatgag ctgcagaagg ctgtggagga gatgaagagg     2940

gccaaggagg aggcccagca gaaggaggcc aaggtgaagc tgctgacaga gtctgtgaac     3000

tctgtgattg cccaggcccc ccctgtggcc caggaggccc tgaagaagga gctggagacc     3060

ctgacaacca actaccagtg gctgtgcacc aggctgaatg gcaagtgcaa gaccctagag     3120

gaggtgtggg cctgctggca tgagctgctg agctacctgg agaaggccaa caagtggctg     3180

aatgaggtgg agttcaagct gaagaccaca gagaacatcc ctggaggagc tgaggagatc     3240

tctgaggtgc tggacagcct ggagaaccta atgaggcact ctgaggacaa ccccaaccag     3300

atcaggatcc tggcccagac cctgacagat ggaggagtga tggatgagct gatcaatgag     3360

gagctggaga ccttcaacag caggtggagg gagctacatg aggaggctgt gaggaggcag     3420

aagctgctag agcagatcca tacagtgagg gaggagacaa tgatggtgat gacagaggat     3480

atgcccctgg agatcagcta tgtgcccagc acctacctaa cagagatcac ccatgtgagc     3540

caggccctgc tggaggtgga gcagctgctg aatgcccctg acctgtgtgc caaggacttt     3600

gaggacctgt tcaagcagga ggagagcctg aagaacatca aggacagcct gcagcagagc     3660

tcaggcagga ttgatattat ccacagcaag aagacagctg ccctgcagtc tgctacccct     3720

gtggagaggg tgaagctgca ggaggccctg agccagctgg acttccagtg ggagaaggtt     3780

aacaagatgt acaaggacag gcagggcagg tttgacaggt cagtggagaa gtggaggagg     3840

ttccactatg acatcaagat cttcaaccag tggctgacag aggctgagca gttcctaagg     3900

aagacccaga tccctgagaa ctgggagcat gccaagtaca agtggtacct taaggagctg     3960

caggatggca ttggccagag gcagacagtg gtgaggaccc tgaatgctac aggggaggag     4020

attatccagc agagcagcaa gacagatgcc agtatcctgc aggagaagct gggcagcctg     4080

aacctgaggt ggcaggaggt gtgcaagcag ctgtctgaca ggaagaagag gctggaggag     4140

cagcctgacc tggcccctgg cctgacaaca attggagcca gccctaccca gacagtgacc     4200

ctggtgaccc agcctgtggt gaccaaggag acagctatca gcaagctgga gatgcccagc     4260

agcctgatgc tggaggtgcc tgccctggct gacttcaaca gggcctggac agagctgaca     4320

gactggctga gcctgctgga ccaggtgatc aagagccaga gggtgatggt gggggacctg     4380

gaggatatca atgagatgat tatcaagcag aaggctacaa tgcaggacct ggagcagagg     4440

aggccccagc tggaggagct gattacagct gcccagaacc taaagaacaa gaccagcaac     4500

caggaggcca ggacaattat tacagacagg attgagagga tccagaacca gtgggatgag     4560

gtgcaggagc acctgcagtt tacgcgtttt gcggccgctt tacgtagata agtagcatgg     4620

cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg     4680

cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg     4740

ggcggcctca gtgagcgagc gagcgcgc                                        4768


