                         SEQUENCE LISTING

<110>  UBO
       INSERM
       CHRU de Brest
 
<120>  Substance interacting with C terminal fragment of the STIM1 
       fraction localized to the plasma membrane of the cells, for its 
       use in the treatment of cancers, and in screening and diagnostic 
       methods

<130>  BNT225656PC00

<150>  EP19305374.1
<151>  2019-03-25

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Val Cys Val Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu 
1               5                   10                  15      


Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Ala Thr 
            20                  25                  30          


Gly Thr Ser Ser Gly Ala Asn Ser Glu Glu Ser Thr Ala Ala Glu Phe 
        35                  40                  45              


Cys Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser 
    50                  55                  60                  


Phe Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn 
65                  70                  75                  80  


Gly Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu 
                85                  90                  95      


Asn Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp 
            100                 105                 110         


Lys Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu 
        115                 120                 125             


Val Tyr Asn Trp Thr Val Asp Glu Val Val Gln Trp Leu Ile Thr Tyr 
    130                 135                 140                 


Val Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Ser 
145                 150                 155                 160 


Gly His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly 
                165                 170                 175     


Thr Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu 
            180                 185                 190         


Lys Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His 
        195                 200                 205             


Asn His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val 
    210                 215                 220                 


Gly Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His 
225                 230                 235                 240 


Met Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln 
                245                 250                 255     


Ser Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His 
            260                 265                 270         


Arg Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp 
        275                 280                 285             


Glu Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg 
    290                 295                 300                 


Glu Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu 
305                 310                 315                 320 


Leu Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu 
                325                 330                 335     


Ser His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln 
            340                 345                 350         


Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn 
        355                 360                 365             


Ala Glu Lys Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys 
    370                 375                 380                 


Lys Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser 
385                 390                 395                 400 


Ser Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu 
                405                 410                 415     


Ser Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln 
            420                 425                 430         


Ile Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His 
        435                 440                 445             


Ser Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr 
    450                 455                 460                 


Arg Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met 
465                 470                 475                 480 


Asp Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln 
                485                 490                 495     


Ser Ser Val Arg Gln Arg Leu Thr Glu Pro Gln His Gly Leu Gly Ser 
            500                 505                 510         


Gln Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Met Ser 
        515                 520                 525             


Asp Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Ser Arg Ala Ala 
    530                 535                 540                 


Asp Glu Ala Leu Asn Ala Met Thr Ser Asn Gly Ser His Arg Leu Ile 
545                 550                 555                 560 


Glu Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro 
                565                 570                 575     


Ala Leu Ala Lys Lys Ala Leu Leu Ala Leu Asn His Gly Leu Asp Lys 
            580                 585                 590         


Ala His Ser Leu Met Glu Leu Ser Pro Ser Ala Pro Pro Gly Gly Ser 
        595                 600                 605             


Pro His Leu Asp Ser Ser Arg Ser His Ser Pro Ser Ser Pro Asp Pro 
    610                 615                 620                 


Asp Thr Pro Ser Pro Val Gly Asp Ser Arg Ala Leu Gln Ala Ser Arg 
625                 630                 635                 640 


Asn Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Val Ala Glu Glu 
                645                 650                 655     


Asp Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys 
            660                 665                 670         


Lys Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys 
        675                 680                 685 


<210>  2
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  2

Asn Arg Tyr Ser Lys Glu His Met Lys Lys Met Met Lys Asp Leu Glu 
1               5                   10                  15      


Gly Leu His Arg Ala Glu Gln Ser Leu His Asp Leu Gln Glu Arg Leu 
            20                  25                  30          


His Lys Ala Gln Glu Glu His Arg Thr Val Glu Val Glu Lys Val His 
        35                  40                  45              


Leu Glu Lys Lys Leu Arg Asp Glu Ile Asn Leu Ala Lys Gln Glu Ala 
    50                  55                  60                  


Gln Arg Leu Lys Glu Leu Arg Glu Gly Thr Glu Asn Glu Arg Ser Arg 
65                  70                  75                  80  


Gln Lys Tyr Ala Glu Glu Glu Leu Glu Gln Val Arg Glu Ala Leu Arg 
                85                  90                  95      


Lys Ala Glu Lys Glu Leu Glu Ser His Ser Ser Trp Tyr Ala Pro Glu 
            100                 105                 110         


Ala Leu Gln Lys Trp Leu Gln Leu Thr His Glu Val Glu Val Gln Tyr 
        115                 120                 125             


Tyr Asn Ile Lys Lys Gln Asn Ala Glu Lys Gln Leu Leu Val Ala Lys 
    130                 135                 140                 


Glu Gly Ala Glu Lys Ile Lys Lys Lys Arg Asn Thr Leu Phe Gly Thr 
145                 150                 155                 160 


Phe His Val Ala His Ser Ser Ser Leu Asp Asp Val Asp His Lys Ile 
                165                 170                 175     


Leu Thr Ala Lys Gln Ala Leu Ser Glu Val Thr Ala Ala Leu Arg Glu 
            180                 185                 190         


Arg Leu His Arg Trp Gln Gln Ile Glu Ile Leu Cys Gly Phe Gln Ile 
        195                 200                 205             


Val Asn Asn Pro Gly Ile His Ser Leu Val Ala Ala Leu Asn Ile Asp 
    210                 215                 220                 


Pro Ser Trp Met Gly Ser Thr Arg Pro Asn Pro Ala His Phe Ile Met 
225                 230                 235                 240 


Thr Asp Asp Val Asp Asp Met Asp Glu Glu Ile Val Ser Pro Leu Ser 
                245                 250                 255     


Met Gln Ser Pro Ser Leu Gln Ser Ser Val Arg Gln Arg Leu Thr Glu 
            260                 265                 270         


Pro Gln His Gly Leu Gly Ser Gln Arg Asp Leu Thr His Ser Asp Ser 
        275                 280                 285             


Glu Ser Ser Leu His Met Ser Asp Arg Gln Arg Val Ala Pro Lys Pro 
    290                 295                 300                 


Pro Gln Met Ser Arg Ala Ala Asp Glu Ala Leu Asn Ala Met Thr Ser 
305                 310                 315                 320 


Asn Gly Ser His Arg Leu Ile Glu Gly Val His Pro Gly Ser Leu Val 
                325                 330                 335     


Glu Lys Leu Pro Asp Ser Pro Ala Leu Ala Lys Lys Ala Leu Leu Ala 
            340                 345                 350         


Leu Asn His Gly Leu Asp Lys Ala His Ser Leu Met Glu Leu Ser Pro 
        355                 360                 365             


Ser Ala Pro Pro Gly Gly Ser Pro His Leu Asp Ser Ser Arg Ser His 
    370                 375                 380                 


Ser Pro Ser Ser Pro Asp Pro Asp Thr Pro Ser Pro Val Gly Asp Ser 
385                 390                 395                 400 


Arg Ala Leu Gln Ala Ser Arg Asn Thr Arg Ile Pro His Leu Ala Gly 
                405                 410                 415     


Lys Lys Ala Val Ala Glu Glu Asp Asn Gly Ser Ile Gly Glu Glu Thr 
            420                 425                 430         


Asp Ser Ser Pro Gly Arg Lys Lys Phe Pro Leu Lys Ile Phe Lys Lys 
        435                 440                 445             


Pro Leu Lys Lys 
    450         


<210>  3
<211>  19
<212>  RNA
<213>  Unknown

<220>
<223>  Artificial sequence

<400>  3
ugagggaaga ccucaauua                                                    19


