﻿               SEQUENCE LISTING

<110> Technische Universität München

<120> High affinity Anticalins directed against human CD98hc

<130> AC1243 PCT

<150> EP 19 16 5966.3
<151> 2019-03-28

<160> 30

<170> BiSSAP 1.3.6

<210> 1
<211> 419
<212> PRT
<213> Homo sapiens


<220> 
<223> huCD98hcED

<400> 1
Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile 
1               5                   10                  15      
Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly 
            20                  25                  30          
Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu 
        35                  40                  45              
Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr 
    50                  55                  60                  
Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp 
65                  70                  75                  80  
Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp 
                85                  90                  95      
Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val 
            100                 105                 110         
Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln 
        115                 120                 125             
Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp 
    130                 135                 140                 
Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser 
145                 150                 155                 160 
Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln 
                165                 170                 175     
Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser 
            180                 185                 190         
Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val 
        195                 200                 205             
Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu 
    210                 215                 220                 
Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg 
225                 230                 235                 240 
Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser 
                245                 250                 255     
Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro 
            260                 265                 270         
Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile 
        275                 280                 285             
Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp 
    290                 295                 300                 
Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser 
305                 310                 315                 320 
Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly 
                325                 330                 335     
Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe 
            340                 345                 350         
Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln 
        355                 360                 365             
Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu 
    370                 375                 380                 
Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu 
385                 390                 395                 400 
Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro 
                405                 410                 415     
Tyr Ala Ala 
            

<210> 2
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11vs

<400> 2
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Thr Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gly Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Ser Gly Gln Lys Lys Cys Met Tyr Ser Ile 
65                  70                  75                  80  
Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Ala Pro Gly Arg Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ser Val Thr Gln 
        115                 120                 125             
Asn Arg Glu Gly Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 3
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.1

<400> 3
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Thr Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gly Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Ser Gly Gln Lys Lys Cys Met Tyr Ser Ile 
65                  70                  75                  80  
Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Ala Pro Gly Gln Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ser Val Thr Gln 
        115                 120                 125             
Asn Arg Glu Gly Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Ile Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 4
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.2

<400> 4
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Thr Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gly Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Ser Gly Gln Lys Lys Cys Met Tyr Ser Ile 
65                  70                  75                  80  
Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Ala Pro Gly Arg Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Leu Val Phe Phe Lys Ser Val Thr Gln 
        115                 120                 125             
Asn Arg Glu Gly Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 5
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.3

<400> 5
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Thr Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gly Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Phe Gly Gln Lys Lys Cys Met Tyr Ser Ile 
65                  70                  75                  80  
Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Ala Pro Gly Arg Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln Tyr Ala Met Val Phe Phe Lys Ser Val Thr Gln 
        115                 120                 125             
Asn Arg Glu Gly Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 6
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.4

<400> 6
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Thr Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gly Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Phe 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Phe Gly Gln Lys Lys Cys Met Tyr Ser Ile 
65                  70                  75                  80  
Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Ala Pro Gly Arg Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ser Val Thr Gln 
        115                 120                 125             
Asn Arg Glu Gly Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 7
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.5

<400> 7
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Thr Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gly Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Phe Gly Gln Lys Lys Cys Met Asn Ser Ile 
65                  70                  75                  80  
Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Ala Pro Gly Arg Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln Tyr Ala Met Val Phe Phe Lys Ser Val Thr Gln 
        115                 120                 125             
Asn Arg Glu Gly Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 8
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.6

<400> 8
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Thr Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gly Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Phe Gly Gln Lys Lys Cys Met Tyr Ser Ile 
65                  70                  75                  80  
Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Ala Pro Gly Arg Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln Tyr Ala Met Val Phe Phe Lys Ser Glu Thr Gln 
        115                 120                 125             
Asn Arg Glu Gly Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Tyr Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 9
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.7

<400> 9
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Thr Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gly Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Phe Gly Gln Lys Lys Cys Met Tyr Ser Ile 
65                  70                  75                  80  
Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Ala Pro Gly Arg Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ser Val Thr Gln 
        115                 120                 125             
Asn Arg Glu Glu Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 10
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.8

<400> 10
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Thr Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gly Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Ser Gly Gln Lys Lys Cys Met Tyr Ser Ile 
65                  70                  75                  80  
Val Ser Phe Val Pro Gly Ser Gln Pro Gly Glu Tyr Asn Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Ala Pro Gly Arg Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ser Val Thr Gln 
        115                 120                 125             
Asn Arg Glu Gly Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 11
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.9

<400> 11
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Thr Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gly Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Ser Gly Gln Thr Lys Cys Met Tyr Ser Ile 
65                  70                  75                  80  
Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Ala Pro Gly Arg Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ser Val Thr Gln 
        115                 120                 125             
Asn Arg Glu Gly Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 12
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-P3D11

<400> 12
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Thr Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gly Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Phe Gly Gln Lys Lys Cys Met Tyr Ser Ile 
65                  70                  75                  80  
Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Ala Pro Gly Arg Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ser Val Thr Gln 
        115                 120                 125             
Asn Arg Glu Gly Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 13
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-P3A12

<400> 13
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Arg Ala Gly Asn Leu Gly Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Tyr Val Trp Phe Asp Leu Lys Lys Cys Lys Tyr Ser Ile 
65                  70                  75                  80  
His Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Lys 
                85                  90                  95      
Ile Lys Ser Gly Pro Gly His Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Gly Gln 
        115                 120                 125             
Asn Arg Glu Asn Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 14
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> hCD98hcED-P1E4

<400> 14
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Ile Ala Gly Asn Ser Met Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Phe Lys Met Thr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Arg Val Arg Phe Asp Asp Lys Lys Cys Leu Tyr Arg Ile 
65                  70                  75                  80  
Leu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Arg Pro Gly Trp Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Arg Val His Gln 
        115                 120                 125             
Asn Arg Glu Thr Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 15
<211> 1260
<212> DNA
<213> Homo sapiens


<220> 
<223> huCD98hcED

<400> 15
gaactgcctg cacagaaatg gtggcatacc ggtgcactgt atcgtattgg tgatctgcag      60

gcatttcagg gtcatggtgc aggtaatctg gcaggtctga aaggtcgtct ggattatctg     120

agcagcctga aagttaaagg tctggttctg ggtccgattc acaaaaatca gaaagatgat     180

gttgcacaga ccgatctgct gcagattgat ccgaattttg gtagcaaaga agatttcgat     240

agcctgctgc agtcagccaa aaaaaaaagc attcgtgtta ttctggatct gaccccgaat     300

tatcgtggtg aaaatagctg gtttagcacc caggttgata ccgttgcaac caaagtgaaa     360

gatgcactgg aattttggct gcaggcaggc gttgatggtt ttcaggttcg tgatattgaa     420

aatctgaaag acgcaagcag ctttctggca gaatggcaga atattaccaa aggctttagc     480

gaagatcgtc tgctgattgc aggcaccaat agcagcgatc tgcaacaaat tctgagcctg     540

ctggaaagca ataaagacct gctgctgacc agcagctatc tgagcgatag cggtagcacc     600

ggtgaacata ctaaaagcct ggttacccag tatctgaatg caaccggtaa tcgttggtgt     660

agctggtcac tgagccaggc acgcctgctg acctcatttc tgcctgccca gctgctgcgc     720

ctgtatcaac tgatgctgtt taccctgcct ggtacaccgg tttttagcta tggtgatgaa     780

attggtctgg atgcagcagc actgcctggt cagccgatgg aagcaccggt tatgctgtgg     840

gatgaaagca gttttccgga tattccgggt gcagttagcg caaatatgac cgtgaaaggt     900

cagagtgaag atccgggtag tctgctgagc ctgtttcgtc gtctgagtga tcagcgtagt     960

aaagaacgtt cactgctgca tggtgatttt catgcattta gcgcaggtcc gggtctgttt    1020

agctatattc gtcattggga tcagaatgaa cgttttctgg ttgttctgaa ctttggtgat    1080

gttggtctga gtgcaggtct gcaggccagt gatctgcctg caagcgcaag cctgccagca    1140

aaagcggatc tgctgctgag cacccagcct ggtcgtgaag aaggtagtcc gctggaactg    1200

gaacgtctga aactggaacc gcatgaagga ctgctgctgc gttttccgta tgcagcataa    1260


<210> 16
<211> 178
<212> PRT
<213> Artificial Sequence


<220> 
<223> Formula I

<220> 
<221> VARIANT
<222> 7
<223> L

<220> 
<221> VARIANT
<222> 8
<223> I

<220> 
<221> VARIANT
<222> 28
<223> Q or H

<220> 
<221> VARIANT
<222> 33
<223> V

<220> 
<221> VARIANT
<222> 36
<223> R

<220> 
<221> VARIANT
<222> 39
<223> N

<220> 
<221> VARIANT
<222> 40
<223> L or T

<220> 
<221> VARIANT
<222> 41
<223> G

<220> 
<221> VARIANT
<222> 42
<223> L

<220> 
<221> VARIANT
<222> 43
<223> R

<220> 
<221> VARIANT
<222> 45
<223> D

<220> 
<221> VARIANT
<222> 46
<223> K

<220> 
<221> VARIANT
<222> 47
<223> D

<220> 
<221> VARIANT
<222> 48
<223> P

<220> 
<221> VARIANT
<222> 49
<223> A or G

<220> 
<221> VARIANT
<222> 50
<223> K

<220> 
<221> VARIANT
<222> 52
<223> F

<220> 
<221> VARIANT
<222> 64
<223> Y or F

<220> 
<221> VARIANT
<222> 68
<223> Y

<220> 
<221> VARIANT
<222> 70
<223> W

<220> 
<221> VARIANT
<222> 71
<223> F or S

<220> 
<221> VARIANT
<222> 72
<223> D or G

<220> 
<221> VARIANT
<222> 73
<223> L or Q

<220> 
<221> VARIANT
<222> 74
<223> K or T

<220> 
<221> VARIANT
<222> 77
<223> K or M

<220> 
<221> VARIANT
<222> 78
<223> Y or N

<220> 
<221> VARIANT
<222> 79
<223> S

<220> 
<221> VARIANT
<222> 80
<223> I

<220> 
<221> VARIANT
<222> 81
<223> H, G or V

<220> 
<221> VARIANT
<222> 82
<223> T or S

<220> 
<221> VARIANT
<222> 83
<223> F

<220> 
<221> VARIANT
<222> 87
<223> C or S

<220> 
<221> VARIANT
<222> 92
<223> F or Y

<220> 
<221> VARIANT
<222> 93
<223> T or N

<220> 
<221> VARIANT
<222> 94
<223> L

<220> 
<221> VARIANT
<222> 96
<223> N or K

<220> 
<221> VARIANT
<222> 98
<223> K

<220> 
<221> VARIANT
<222> 100
<223> Y, R, G or A

<220> 
<221> VARIANT
<222> 102
<223> G

<220> 
<221> VARIANT
<222> 103
<223> H, R or Q

<220> 
<221> VARIANT
<222> 104
<223> T

<220> 
<221> VARIANT
<222> 106
<223> W

<220> 
<221> VARIANT
<222> 108
<223> V

<220> 
<221> VARIANT
<222> 118
<223> H or Y

<220> 
<221> VARIANT
<222> 120
<223> M or L

<220> 
<221> VARIANT
<222> 123
<223> F

<220> 
<221> VARIANT
<222> 125
<223> W or S

<220> 
<221> VARIANT
<222> 126
<223> V or E

<220> 
<221> VARIANT
<222> 127
<223> G or T

<220> 
<221> VARIANT
<222> 128
<223> Q

<220> 
<221> VARIANT
<222> 130
<223> R

<220> 
<221> VARIANT
<222> 132
<223> N, G or E

<220> 
<221> VARIANT
<222> 133
<223> F

<220> 
<221> VARIANT
<222> 134
<223> A

<220> 
<221> VARIANT
<222> 136
<223> T

<220> 
<221> VARIANT
<222> 138
<223> Y

<220> 
<221> VARIANT
<222> 151
<223> N, I or Y

<220> 
<221> VARIANT
<222> 164
<223> N

<220> 
<221> VARIANT
<222> 165
<223> H

<400> 16
Gln Asp Ser Thr Ser Asp Xaa Xaa Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Xaa Gly Lys Trp Tyr 
            20                  25                  30          
Xaa Val Gly Xaa Ala Gly Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Xaa Xaa 
        35                  40                  45              
Xaa Xaa Met Xaa Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Xaa 
    50                  55                  60                  
Asn Val Thr Xaa Val Xaa Xaa Xaa Xaa Xaa Lys Cys Xaa Xaa Xaa Xaa 
65                  70                  75                  80  
Xaa Xaa Xaa Val Pro Gly Xaa Gln Pro Gly Glu Xaa Xaa Xaa Gly Xaa 
                85                  90                  95      
Ile Xaa Ser Xaa Pro Xaa Xaa Xaa Ser Xaa Leu Xaa Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln Xaa Ala Xaa Val Phe Xaa Lys Xaa Xaa Xaa Xaa 
        115                 120                 125             
Asn Xaa Glu Xaa Xaa Xaa Ile Xaa Leu Xaa Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Xaa Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Xaa Xaa Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

<210> 17
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11vs

<400> 17
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatacc     120

ggactgcgtg aggataagga tccgggaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ctacgtgtgg tctggacaaa agaaatgcat gtacagcatt     240

gtaacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtgca     300

ccgggccgta catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg     360

gtgttcttca agagcgtgac ccagaaccgc gagggatttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa aactttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 18
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.1

<400> 18
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatacc     120

ggactgcgtg aggataagga tccgggaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ctacgtgtgg tctggacaaa agaaatgcat gtacagcatt     240

gtaacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtgca     300

ccgggccaaa catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg     360

gtgttcttca agagcgtgac ccagaaccgc gagggatttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa atttttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 19
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.2

<400> 19
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatacc     120

ggactgcgtg aggataagga tccgggaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ctacgtgtgg tctggacaaa agaaatgcat gtacagcatt     240

gtaacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtgca     300

ccgggccgta catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccttg     360

gtgtttttca agagcgtgac ccagaaccgc gagggatttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa aattttatac gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 20
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.3

<400> 20
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatacc     120

ggactgcgtg aggataagga tccgggaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ctacgtgtgg tttggacaaa agaaatgcat gtacagcatt     240

gtaacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtgca     300

ccgggccgta catcatggtt ggtccgcgtc gtgagcacca actacaacca gtatgccatg     360

gtgttcttca agagcgtgac ccagaaccgc gagggatttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 21
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.4

<400> 21
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatacc     120

ggactgcgtg aggataagga tccgggaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ttaacgtcac ctacgtgtgg tttggacaaa agaaatgcat gtacagcatt     240

gtaacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtgca     300

ccgggccgta catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg     360

gtgttcttca agagcgtgac ccagaaccgc gagggatttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 22
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.5

<400> 22
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatacc     120

ggactgcgtg aggataagga tccgggaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ctacgtgtgg tttggacaaa agaaatgcat gaacagcatt     240

gtaacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtgca     300

ccgggccgta catcatggtt ggtccgcgtc gtgagcacca actacaacca gtatgccatg     360

gtgttcttca agagcgtgac ccagaaccgc gagggatttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 23
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.6

<400> 23
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatacc     120

ggactgcgtg aggataagga tccgggaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ctacgtgtgg tttggacaaa agaaatgcat gtacagcatt     240

gtaacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtgca     300

ccgggccgta catcatggtt ggtccgcgtc gtgagcacca actacaacca gtatgccatg     360

gtgttcttca agagcgagac ccagaaccgc gagggatttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa tattttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 24
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.7

<400> 24
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatacc     120

ggactgcgtg aggataagga tccgggaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ctacgtgtgg tttggacaaa agaaatgcat gtacagcatt     240

gtaacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtgca     300

ccgggccgta catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg     360

gtgttcttca agagcgtgac ccagaaccgc gaggaatttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 25
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.8

<400> 25
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatacc     120

ggactgcgtg aggataagga tccgggaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ctacgtgtgg tctggacaaa agaaatgcat gtacagcatt     240

gtatcctttg tgccggggag ccagccgggc gagtataatt taggcaatat taaaagtgca     300

ccaggccgta catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg     360

gtgttcttca agagcgtgac ccagaaccgc gagggatttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 26
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-D11.9

<400> 26
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatacc     120

ggactgcgtg aggataagga tccgggaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ctacgtgtgg tctggacaaa cgaaatgcat gtacagcatt     240

gtaacctttg tgccggggag tcagccgggc gagtttactt taggcaatat taaaagtgca     300

ccgggccgta catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg     360

gtgttcttca agagcgtgac ccagaaccgc gagggatttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 27
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-P3D11

<400> 27
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatacc     120

ggactgcgtg aggataagga tccgggaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ctacgtgtgg tttggacaaa agaaatgcat gtacagcatt     240

ggaacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtgca     300

ccgggccgta catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg     360

gtgttcttca agagcgtgac ccagaaccgc gagggatttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 28
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-P3A12

<400> 28
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggccgtgc cggaaatctg     120

ggactgcgtg aggataagga tccggcaaaa atgttcgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ctacgtgtgg tttgacctga agaaatgcaa atacagcatt     240

cacacctttg tgccggggag ccagccgggc gagtttactt taggcaaaat taaaagtgga     300

ccgggccaca catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg     360

gtgttcttca agtgggtggg acagaaccgc gagaattttg caatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 29
<211> 534
<212> DNA
<213> Artificial Sequence


<220> 
<223> hCD98hcED-P1E4

<400> 29
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcatcgc cggaaatagc     120

atgctgcgtg aggataagga tccgttcaaa atgaccgcga ccatttacga gttgaaagaa     180

gataaatcat ataacgtcac ccgtgtgcgt tttgacgaca agaaatgcct gtaccgtatt     240

ctgacctttg tgccggggag ccagccgggc gagtttactt taggcaatat taaaagtcgt     300

ccgggctgga catcatggtt ggtccgcgtc gtgagcacca actacaacca gcatgccatg     360

gtgttcttca agcgtgtgca ccagaaccgc gagacctttt ggatcacact gtacgggcgc     420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc     480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc           534


<210> 30
<211> 178
<212> PRT
<213> Homo sapiens


<220> 
<223> Wild type Lcn2

<400> 30
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  
Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             
Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 
        

