                         SEQUENCE LISTING

<110>  ݿҽҩƼ޹˾
       ϳ߹ɷ޹˾Synimmune, Inc.
 
<120>  ٲϸƼӦ

<130>  UP-201606-59:52

<150>  CN2019102375601

<151>  2019-03-27

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  132
<212>  PRT
<213>  ˣHomo sapiens

<400>  1

Met Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg 
1               5                   10                  15      


Asp Ala Arg Ala Gln Ser Val Ser Gln His Asn His His Val Ile Leu 
            20                  25                  30          


Ser Glu Ala Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly 
        35                  40                  45              


Thr Val Asn Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg 
                85                  90                  95      


Lys Pro Ser Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Asn Asp Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
        115                 120                 125             


Val Arg Ala Asn 
    130         


<210>  2
<211>  133
<212>  PRT
<213>  ˣHomo sapiens

<400>  2

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Glu Ala Gly Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu 
    130             


<210>  3
<211>  9
<212>  PRT
<213>  ˣHomo sapiens

<400>  3

Lys Ile Phe Gly Ser Leu Ala Phe Leu 
1               5                   


<210>  4
<211>  272
<212>  PRT
<213>  ˣHomo sapiens

<400>  4

Met Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg 
1               5                   10                  15      


Asp Ala Arg Ala Gln Ser Val Ser Gln His Asn His His Val Ile Leu 
            20                  25                  30          


Ser Glu Ala Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly 
        35                  40                  45              


Thr Val Asn Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg 
                85                  90                  95      


Lys Pro Ser Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Asn Asp Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
        115                 120                 125             


Val Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  5
<211>  272
<212>  PRT
<213>  ˹Уartificial sequence

<400>  5

Met Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg 
1               5                   10                  15      


Asp Ala Arg Ala Gln Ser Val Ser Gln His Asn His His Val Ile Leu 
            20                  25                  30          


Ser Glu Ala Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly 
        35                  40                  45              


Thr Val Asn Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg 
                85                  90                  95      


Lys Pro Ser Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Asn Asp Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
        115                 120                 125             


Val Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  6
<211>  268
<212>  PRT
<213>  ˹Уartificial sequence

<400>  6

Met Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg 
1               5                   10                  15      


Asp Ala Arg Ala Gln Ser Val Ser Gln His Asn His His Val Ile Leu 
            20                  25                  30          


Ser Glu Ala Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly 
        35                  40                  45              


Thr Val Asn Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg 
                85                  90                  95      


Lys Pro Ser Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Asn Asp Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
        115                 120                 125             


Val Arg Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  7
<211>  312
<212>  PRT
<213>  ˣHomo sapiens

<400>  7

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Glu Ala Gly Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Ser Arg Gly 
305                 310         


<210>  8
<211>  312
<212>  PRT
<213>  ˹Уartificial sequence

<400>  8

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Glu Ala Gly Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Ser Arg Gly 
305                 310         


<210>  9
<211>  306
<212>  PRT
<213>  ˹Уartificial sequence

<400>  9

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Glu Ala Gly Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  10
<211>  396
<212>  DNA
<213>  ˣHomo sapiens

<400>  10
atgctcctgt tgctcatacc agtgctgggg atgatttttg ccctgagaga tgccagagcc       60

cagtctgtga gccagcataa ccaccacgta attctctctg aagcagcctc actggagttg      120

ggatgcaact attcctatgg tggaactgtt aatctcttct ggtatgtcca gtaccctggt      180

caacaccttc agcttctcct caagtacttt tcaggggatc cactggttaa aggcatcaag      240

ggctttgagg ctgaatttat aaagagtaaa ttctccttta atctgaggaa accctctgtg      300

cagtggagtg acacagctga gtacttctgt gccgtgaatg ataacgacta caagctcagc      360

tttggagccg gaaccacagt aactgtaaga gcaaac                                396


<210>  11
<211>  399
<212>  DNA
<213>  ˣHomo sapiens

<400>  11
atgggctgca ggctgctctg ctgtgcggtt ctctgtctcc tgggagcggt ccccatggaa       60

acgggagtta cgcagacacc aagacacctg gtcatgggaa tgacaaataa gaagtctttg      120

aaatgtgaac aacatctggg tcataacgct atgtattggt acaagcaaag tgctaagaag      180

ccactggagc tcatgtttgt ctacagtctt gaagaacggg ttgaaaacaa cagtgtgcca      240

agtcgcttct cacctgaatg ccccaacagc tctcacttat tccttcacct acacaccctg      300

cagccagaag actcggccct gtatctctgc gccagcagcc aagaagccgg ttcctacaat      360

gagcagttct tcgggccagg gacacggctc accgtgcta                             399


<210>  12
<211>  819
<212>  DNA
<213>  ˣHomo sapiens

<400>  12
atgctcctgt tgctcatacc agtgctgggg atgatttttg ccctgagaga tgccagagcc       60

cagtctgtga gccagcataa ccaccacgta attctctctg aagcagcctc actggagttg      120

ggatgcaact attcctatgg tggaactgtt aatctcttct ggtatgtcca gtaccctggt      180

caacaccttc agcttctcct caagtacttt tcaggggatc cactggttaa aggcatcaag      240

ggctttgagg ctgaatttat aaagagtaaa ttctccttta atctgaggaa accctctgtg      300

cagtggagtg acacagctga gtacttctgt gccgtgaatg ataacgacta caagctcagc      360

tttggagccg gaaccacagt aactgtaaga gcaaatatcc agaaccctga ccctgccgtg      420

taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat      480

tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaaccgtg      540

ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct      600

gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc      660

agcccagaaa gttcctgtga tgtcaagctg gtcgagaaaa gctttgaaac agatacgaac      720

ctaaactttc aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg      780

tttaatctgc tcatgacgct gcggctgtgg tccagctga                             819


<210>  13
<211>  819
<212>  DNA
<213>  ˹Уartificial sequence

<400>  13
atgctcctgt tgctcatacc agtgctgggg atgatttttg ccctgagaga tgccagagcc       60

cagtctgtga gccagcataa ccaccacgta attctctctg aagcagcctc actggagttg      120

ggatgcaact attcctatgg tggaactgtt aatctcttct ggtatgtcca gtaccctggt      180

caacaccttc agcttctcct caagtacttt tcaggggatc cactggttaa aggcatcaag      240

ggctttgagg ctgaatttat aaagagtaaa ttctccttta atctgaggaa accctctgtg      300

cagtggagtg acacagctga gtacttctgt gccgtgaatg ataacgacta caagctcagc      360

tttggagccg gaaccacagt aactgtaaga gcaaatatcc agaaccctga ccctgccgtg      420

taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat      480

tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaatgcgtg      540

ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct      600

gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc      660

agcccagaaa gttcctgtga tgtcaagctg gtcgagaaaa gctttgaaac agatacgaac      720

ctaaactttc aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg      780

tttaatctgc tcatgacgct gcggctgtgg tccagctga                             819


<210>  14
<211>  807
<212>  DNA
<213>  ˹Уartificial sequence

<400>  14
atgctcctgt tgctcatacc agtgctgggg atgatttttg ccctgagaga tgccagagcc       60

cagtctgtga gccagcataa ccaccacgta attctctctg aagcagcctc actggagttg      120

ggatgcaact attcctatgg tggaactgtt aatctcttct ggtatgtcca gtaccctggt      180

caacaccttc agcttctcct caagtacttt tcaggggatc cactggttaa aggcatcaag      240

ggctttgagg ctgaatttat aaagagtaaa ttctccttta atctgaggaa accctctgtg      300

cagtggagtg acacagctga gtacttctgt gccgtgaatg ataacgacta caagctcagc      360

tttggagccg gaaccacagt aactgtaaga gcaaacatcc agaacccaga acctgctgtg      420

taccagttaa aagatcctcg gtctcaggac agcaccctct gcctgttcac cgactttgac      480

tcccaaatca atgtgccgaa aaccatggaa tctggaacgt tcatcactga caaaactgtg      540

ctggacatga aagctatgga ttccaagagc aatggggcca ttgcctggag caaccagaca      600

agcttcacct gccaagatat cttcaaagag accaacgcca cctaccccag ttcagacgtt      660

ccctgtgatg ccacgttgac cgagaaaagc tttgaaacag atatgaacct aaactttcaa      720

aacctgtcag ttatgggact ccgaatcctc ctgctgaaag tagcgggatt taacctgctc      780

atgacgctga ggctgtggtc cagttga                                          807


<210>  15
<211>  939
<212>  DNA
<213>  ˣHomo sapiens

<400>  15
atgggctgca ggctgctctg ctgtgcggtt ctctgtctcc tgggagcggt ccccatggaa       60

acgggagtta cgcagacacc aagacacctg gtcatgggaa tgacaaataa gaagtctttg      120

aaatgtgaac aacatctggg tcataacgct atgtattggt acaagcaaag tgctaagaag      180

ccactggagc tcatgtttgt ctacagtctt gaagaacggg ttgaaaacaa cagtgtgcca      240

agtcgcttct cacctgaatg ccccaacagc tctcacttat tccttcacct acacaccctg      300

cagccagaag actcggccct gtatctctgc gccagcagcc aagaagccgg ttcctacaat      360

gagcagttct tcgggccagg gacacggctc accgtgctag aggacctgaa aaacgtgttc      420

ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc      480

acactggtat gcctggccac aggcttctac cccgaccacg tggagctgag ctggtgggtg      540

aatgggaagg aggtgcacag tggggtcagc acagacccgc agcccctcaa ggagcagccc      600

gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg      660

cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac      720

gagtggaccc aggatagggc caaacccgtc acccagatcg tcagcgccga ggcctggggt      780

agagcagact gtggcttcac ctccgagtct taccagcaag gggtcctgtc tgccaccatc      840

ctctatgaga tcttgctagg gaaggccacc ttgtatgccg tgctggtcag tgccctcgtg      900

ctgatggcca tggtcaagag aaaggattcc agaggctaa                             939


<210>  16
<211>  939
<212>  DNA
<213>  ˹Уartificial sequence

<400>  16
atgggctgca ggctgctctg ctgtgcggtt ctctgtctcc tgggagcggt ccccatggaa       60

acgggagtta cgcagacacc aagacacctg gtcatgggaa tgacaaataa gaagtctttg      120

aaatgtgaac aacatctggg tcataacgct atgtattggt acaagcaaag tgctaagaag      180

ccactggagc tcatgtttgt ctacagtctt gaagaacggg ttgaaaacaa cagtgtgcca      240

agtcgcttct cacctgaatg ccccaacagc tctcacttat tccttcacct acacaccctg      300

cagccagaag actcggccct gtatctctgc gccagcagcc aagaagccgg ttcctacaat      360

gagcagttct tcgggccagg gacacggctc accgtgctag aggacctgaa aaacgtgttc      420

ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc      480

acactggtat gcctggccac aggcttctac cccgaccacg tggagctgag ctggtgggtg      540

aatgggaagg aggtgcacag tggggtctgc acagacccgc agcccctcaa ggagcagccc      600

gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg      660

cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac      720

gagtggaccc aggatagggc caaacccgtc acccagatcg tcagcgccga ggcctggggt      780

agagcagact gtggcttcac ctccgagtct taccagcaag gggtcctgtc tgccaccatc      840

ctctatgaga tcttgctagg gaaggccacc ttgtatgccg tgctggtcag tgccctcgtg      900

ctgatggcca tggtcaagag aaaggattcc agaggctaa                             939


<210>  17
<211>  921
<212>  DNA
<213>  ˹Уartificial sequence

<400>  17
atgggctgca ggctgctctg ctgtgcggtt ctctgtctcc tgggagcggt ccccatggaa       60

acgggagtta cgcagacacc aagacacctg gtcatgggaa tgacaaataa gaagtctttg      120

aaatgtgaac aacatctggg tcataacgct atgtattggt acaagcaaag tgctaagaag      180

ccactggagc tcatgtttgt ctacagtctt gaagaacggg ttgaaaacaa cagtgtgcca      240

agtcgcttct cacctgaatg ccccaacagc tctcacttat tccttcacct acacaccctg      300

cagccagaag actcggccct gtatctctgc gccagcagcc aagaagccgg ttcctacaat      360

gagcagttct tcgggccagg gacacggctc accgtgctag aggatctgag aaatgtgact      420

ccacccaagg tctccttgtt tgagccatca aaagcagaga ttgcaaacaa acaaaaggct      480

accctcgtgt gcttggccag gggcttcttc cctgaccacg tggagctgag ctggtgggtg      540

aatggcaagg aggtccacag tggggtcagc acggaccctc aggcctacaa ggagagcaat      600

tatagctact gcctgagcag ccgcctgagg gtctctgcta ccttctggca caatcctcgc      660

aaccacttcc gctgccaagt gcagttccat gggctttcag aggaggacaa gtggccagag      720

ggctcaccca aacctgtcac acagaacatc agtgcagagg cctggggccg agcagactgt      780

gggattacct cagcatccta tcaacaaggg gtcttgtctg ccaccatcct ctatgagatc      840

ctgctaggga aagccaccct gtatgctgtg cttgtcagta cactggtggt gatggctatg      900

gtcaaaagaa agaattcata a                                                921


<210>  18
<211>  1851
<212>  DNA
<213>  ˹Уartificial sequence

<400>  18
atgggctgca ggctgctctg ctgtgcggtt ctctgtctcc tgggagcggt ccccatggaa       60

acgggagtta cgcagacacc aagacacctg gtcatgggaa tgacaaataa gaagtctttg      120

aaatgtgaac aacatctggg tcataacgct atgtattggt acaagcaaag tgctaagaag      180

ccactggagc tcatgtttgt ctacagtctt gaagaacggg ttgaaaacaa cagtgtgcca      240

agtcgcttct cacctgaatg ccccaacagc tctcacttat tccttcacct acacaccctg      300

cagccagaag actcggccct gtatctctgc gccagcagcc aagaagccgg ttcctacaat      360

gagcagttct tcgggccagg gacacggctc accgtgctag aggacctgaa aaacgtgttc      420

ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc      480

acactggtat gcctggccac aggcttctac cccgaccacg tggagctgag ctggtgggtg      540

aatgggaagg aggtgcacag tggggtcagc acagacccgc agcccctcaa ggagcagccc      600

gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg      660

cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac      720

gagtggaccc aggatagggc caaacccgtc acccagatcg tcagcgccga ggcctggggt      780

agagcagact gtggcttcac ctccgagtct taccagcaag gggtcctgtc tgccaccatc      840

ctctatgaga tcttgctagg gaaggccacc ttgtatgccg tgctggtcag tgccctcgtg      900

ctgatggcca tggtcaagag aaaggattcc agaggccgtg ccaagcgatc cggaagcgga      960

gcccctgtaa agcagacttt gaattttgac cttctcaagt tggcgggaga cgtcgagtcc     1020

aaccctgggc ccatgctcct gttgctcata ccagtgctgg ggatgatttt tgccctgaga     1080

gatgccagag cccagtctgt gagccagcat aaccaccacg taattctctc tgaagcagcc     1140

tcactggagt tgggatgcaa ctattcctat ggtggaactg ttaatctctt ctggtatgtc     1200

cagtaccctg gtcaacacct tcagcttctc ctcaagtact tttcagggga tccactggtt     1260

aaaggcatca agggctttga ggctgaattt ataaagagta aattctcctt taatctgagg     1320

aaaccctctg tgcagtggag tgacacagct gagtacttct gtgccgtgaa tgataacgac     1380

tacaagctca gctttggagc cggaaccaca gtaactgtaa gagcaaatat ccagaaccct     1440

gaccctgccg tgtaccagct gagagactct aaatccagtg acaagtctgt ctgcctattc     1500

accgattttg attctcaaac aaatgtgtca caaagtaagg attctgatgt gtatatcaca     1560

gacaaaaccg tgctagacat gaggtctatg gacttcaaga gcaacagtgc tgtggcctgg     1620

agcaacaaat ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac     1680

accttcttcc ccagcccaga aagttcctgt gatgtcaagc tggtcgagaa aagctttgaa     1740

acagatacga acctaaactt tcaaaacctg tcagtgattg ggttccgaat cctcctcctg     1800

aaagtggccg ggtttaatct gctcatgacg ctgcggctgt ggtccagctg a              1851


<210>  19
<211>  1851
<212>  DNA
<213>  ˹Уartificial sequence

<400>  19
atgggctgca ggctgctctg ctgtgcggtt ctctgtctcc tgggagcggt ccccatggaa       60

acgggagtta cgcagacacc aagacacctg gtcatgggaa tgacaaataa gaagtctttg      120

aaatgtgaac aacatctggg tcataacgct atgtattggt acaagcaaag tgctaagaag      180

ccactggagc tcatgtttgt ctacagtctt gaagaacggg ttgaaaacaa cagtgtgcca      240

agtcgcttct cacctgaatg ccccaacagc tctcacttat tccttcacct acacaccctg      300

cagccagaag actcggccct gtatctctgc gccagcagcc aagaagccgg ttcctacaat      360

gagcagttct tcgggccagg gacacggctc accgtgctag aggacctgaa aaacgtgttc      420

ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc      480

acactggtat gcctggccac aggcttctac cccgaccacg tggagctgag ctggtgggtg      540

aatgggaagg aggtgcacag tggggtctgc acagacccgc agcccctcaa ggagcagccc      600

gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg      660

cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac      720

gagtggaccc aggatagggc caaacccgtc acccagatcg tcagcgccga ggcctggggt      780

agagcagact gtggcttcac ctccgagtct taccagcaag gggtcctgtc tgccaccatc      840

ctctatgaga tcttgctagg gaaggccacc ttgtatgccg tgctggtcag tgccctcgtg      900

ctgatggcca tggtcaagag aaaggattcc agaggccgtg ccaagcgatc cggaagcgga      960

gcccctgtaa agcagacttt gaattttgac cttctcaagt tggcgggaga cgtcgagtcc     1020

aaccctgggc ccatgctcct gttgctcata ccagtgctgg ggatgatttt tgccctgaga     1080

gatgccagag cccagtctgt gagccagcat aaccaccacg taattctctc tgaagcagcc     1140

tcactggagt tgggatgcaa ctattcctat ggtggaactg ttaatctctt ctggtatgtc     1200

cagtaccctg gtcaacacct tcagcttctc ctcaagtact tttcagggga tccactggtt     1260

aaaggcatca agggctttga ggctgaattt ataaagagta aattctcctt taatctgagg     1320

aaaccctctg tgcagtggag tgacacagct gagtacttct gtgccgtgaa tgataacgac     1380

tacaagctca gctttggagc cggaaccaca gtaactgtaa gagcaaatat ccagaaccct     1440

gaccctgccg tgtaccagct gagagactct aaatccagtg acaagtctgt ctgcctattc     1500

accgattttg attctcaaac aaatgtgtca caaagtaagg attctgatgt gtatatcaca     1560

gacaaatgcg tgctagacat gaggtctatg gacttcaaga gcaacagtgc tgtggcctgg     1620

agcaacaaat ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac     1680

accttcttcc ccagcccaga aagttcctgt gatgtcaagc tggtcgagaa aagctttgaa     1740

acagatacga acctaaactt tcaaaacctg tcagtgattg ggttccgaat cctcctcctg     1800

aaagtggccg ggtttaatct gctcatgacg ctgcggctgt ggtccagctg a              1851


<210>  20
<211>  1821
<212>  DNA
<213>  ˹Уartificial sequence

<400>  20
atgggctgca ggctgctctg ctgtgcggtt ctctgtctcc tgggagcggt ccccatggaa       60

acgggagtta cgcagacacc aagacacctg gtcatgggaa tgacaaataa gaagtctttg      120

aaatgtgaac aacatctggg tcataacgct atgtattggt acaagcaaag tgctaagaag      180

ccactggagc tcatgtttgt ctacagtctt gaagaacggg ttgaaaacaa cagtgtgcca      240

agtcgcttct cacctgaatg ccccaacagc tctcacttat tccttcacct acacaccctg      300

cagccagaag actcggccct gtatctctgc gccagcagcc aagaagccgg ttcctacaat      360

gagcagttct tcgggccagg gacacggctc accgtgctag aggatctgag aaatgtgact      420

ccacccaagg tctccttgtt tgagccatca aaagcagaga ttgcaaacaa acaaaaggct      480

accctcgtgt gcttggccag gggcttcttc cctgaccacg tggagctgag ctggtgggtg      540

aatggcaagg aggtccacag tggggtcagc acggaccctc aggcctacaa ggagagcaat      600

tatagctact gcctgagcag ccgcctgagg gtctctgcta ccttctggca caatcctcgc      660

aaccacttcc gctgccaagt gcagttccat gggctttcag aggaggacaa gtggccagag      720

ggctcaccca aacctgtcac acagaacatc agtgcagagg cctggggccg agcagactgt      780

gggattacct cagcatccta tcaacaaggg gtcttgtctg ccaccatcct ctatgagatc      840

ctgctaggga aagccaccct gtatgctgtg cttgtcagta cactggtggt gatggctatg      900

gtcaaaagaa agaattcacg tgccaagcga tccggaagcg gagcccctgt aaagcagact      960

ttgaattttg accttctcaa gttggcggga gacgtcgagt ccaaccctgg gcccatgctc     1020

ctgttgctca taccagtgct ggggatgatt tttgccctga gagatgccag agcccagtct     1080

gtgagccagc ataaccacca cgtaattctc tctgaagcag cctcactgga gttgggatgc     1140

aactattcct atggtggaac tgttaatctc ttctggtatg tccagtaccc tggtcaacac     1200

cttcagcttc tcctcaagta cttttcaggg gatccactgg ttaaaggcat caagggcttt     1260

gaggctgaat ttataaagag taaattctcc tttaatctga ggaaaccctc tgtgcagtgg     1320

agtgacacag ctgagtactt ctgtgccgtg aatgataacg actacaagct cagctttgga     1380

gccggaacca cagtaactgt aagagcaaac atccagaacc cagaacctgc tgtgtaccag     1440

ttaaaagatc ctcggtctca ggacagcacc ctctgcctgt tcaccgactt tgactcccaa     1500

atcaatgtgc cgaaaaccat ggaatctgga acgttcatca ctgacaaaac tgtgctggac     1560

atgaaagcta tggattccaa gagcaatggg gccattgcct ggagcaacca gacaagcttc     1620

acctgccaag atatcttcaa agagaccaac gccacctacc ccagttcaga cgttccctgt     1680

gatgccacgt tgaccgagaa aagctttgaa acagatatga acctaaactt tcaaaacctg     1740

tcagttatgg gactccgaat cctcctgctg aaagtagcgg gatttaacct gctcatgacg     1800

ctgaggctgt ggtccagttg a                                               1821


<210>  21
<211>  1255
<212>  PRT
<213>  ˣHomo sapiens

<400>  21

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  22
<211>  10
<212>  PRT
<213>  ˣHomo sapiens

<400>  22

Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
1               5                   10  


<210>  23
<211>  606
<212>  PRT
<213>  ˹Уartificial sequence

<400>  23

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Leu Glu Glu Arg Val Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Glu Ala Gly Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr 
305                 310                 315                 320 


Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
                325                 330                 335     


Gly Pro Met Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala 
            340                 345                 350         


Leu Arg Asp Ala Arg Ala Gln Ser Val Ser Gln His Asn His His Val 
        355                 360                 365             


Ile Leu Ser Glu Ala Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr 
    370                 375                 380                 


Gly Gly Thr Val Asn Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His 
385                 390                 395                 400 


Leu Gln Leu Leu Leu Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly 
                405                 410                 415     


Ile Lys Gly Phe Glu Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn 
            420                 425                 430         


Leu Arg Lys Pro Ser Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys 
        435                 440                 445             


Ala Val Asn Asp Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr 
    450                 455                 460                 


Val Thr Val Arg Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
465                 470                 475                 480 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
                485                 490                 495     


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
            500                 505                 510         


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
        515                 520                 525             


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
    530                 535                 540                 


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
545                 550                 555                 560 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
                565                 570                 575     


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
            580                 585                 590         


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605     


<210>  24
<211>  22
<212>  DNA
<213>  ˹Уartificial sequence

<400>  24
gcctctggaa tcctttctct tg                                                22


<210>  25
<211>  21
<212>  DNA
<213>  ˹Уartificial sequence

<400>  25
tcagctggac cacagccgca g                                                 21


<210>  26
<211>  36
<212>  DNA
<213>  ˹Уartificial sequence

<400>  26
agagctagcg aattcaacat gggctgcagg ctgctc                                 36


<210>  27
<211>  42
<212>  DNA
<213>  ˹Уartificial sequence

<400>  27
ggatcgcttg gcacgtgaat tctttctttt gaccatagcc at                          42


<210>  28
<211>  39
<212>  DNA
<213>  ˹Уartificial sequence

<400>  28
tccaaccctg ggcccatgct cctgttgctc ataccagtg                              39


<210>  29
<211>  35
<212>  DNA
<213>  ˹Уartificial sequence

<400>  29
gttgattgtc gacgccctca actggaccac agcct                                  35


<210>  30
<211>  23
<212>  DNA
<213>  ˹Уartificial sequence

<400>  30
ggaagatctg gactgaaaat gag                                               23


<210>  31
<211>  24
<212>  DNA
<213>  ˹Уartificial sequence

<400>  31
tgaggtcaga tgtaaccaag atta                                              24


<210>  32
<211>  33
<212>  DNA
<213>  ˹Уartificial sequence

<400>  32
cgcgtcgact actgtaatag taatcaatta cgg                                    33


<210>  33
<211>  33
<212>  DNA
<213>  ˹Уartificial sequence

<400>  33
gacgtcgact aagatacatt gatgagtttg gac                                    33


<210>  34
<211>  21
<212>  DNA
<213>  ˹Уartificial sequence

<400>  34
tccggtttct atgccaaacc t                                                 21


<210>  35
<211>  22
<212>  DNA
<213>  ˹Уartificial sequence

<400>  35
tcctccggtg ataatgacaa ga                                                22


<210>  36
<211>  22
<212>  DNA
<213>  ˹Уartificial sequence

<400>  36
ccattacctt tgactcttgt gt                                                22


<210>  37
<211>  22
<212>  DNA
<213>  ˹Уartificial sequence

<400>  37
ggtagtcctt gtatttagta tc                                                22


<210>  38
<211>  29
<212>  DNA
<213>  ˹Уartificial sequence

<400>  38
catgccttct tgcctcttgt ctcttagat                                         29


<210>  39
<211>  30
<212>  DNA
<213>  ˹Уartificial sequence

<400>  39
ccatgggtgg aatcatattg gaacatgtaa                                        30


<210>  40
<211>  32
<212>  DNA
<213>  ˹Уartificial sequence

<400>  40
cgcgtcgaca tgaggatatt tgctgtcttt at                                     32


<210>  41
<211>  32
<212>  DNA
<213>  ˹Уartificial sequence

<400>  41
ccgctcgagc gtctcctcca aatgtgtatc ac                                     32


<210>  42
<211>  24
<212>  DNA
<213>  ˹Уartificial sequence

<400>  42
cgcctattac acccactcgt gcag                                              24


<210>  43
<211>  62
<212>  DNA
<213>  ˹Уartificial sequence

<400>  43
caccgggaaa tggaggataa gaacattcaa gagatgttct tatcctccat ttcccttttt       60

tg                                                                      62


<210>  44
<211>  62
<212>  DNA
<213>  ˹Уartificial sequence

<400>  44
agctcaaaaa agggaaatgg aggataagaa catctcttga atgttcttat cctccatttc       60

cc                                                                      62


<210>  45
<211>  53
<212>  DNA
<213>  ˹Уartificial sequence

<400>  45
gggaaatgga ggataagaac attcaagaga tgttcttatc ctccatttcc ctt              53


<210>  46
<211>  62
<212>  DNA
<213>  ˹Уartificial sequence

<400>  46
caccggatcc agtcacctct gaacattcaa gagatgttca gaggtgactg gatccttttt       60

tg                                                                      62


<210>  47
<211>  62
<212>  DNA
<213>  ˹Уartificial sequence

<400>  47
agctcaaaaa aggatccagt cacctctgaa catctcttga atgttcagag gtgactggat       60

cc                                                                      62


<210>  48
<211>  53
<212>  DNA
<213>  ˹Уartificial sequence

<400>  48
ggatccagtc acctctgaac attcaagaga tgttcagagg tgactggatc ctt              53


<210>  49
<211>  62
<212>  DNA
<213>  ˹Уartificial sequence

<400>  49
caccgagaat caacacaaca actaattcaa gagattagtt gttgtgttga ttctcttttt       60

tg                                                                      62


<210>  50
<211>  62
<212>  DNA
<213>  ˹Уartificial sequence

<400>  50
agctcaaaaa agagaatcaa cacaacaact aatctcttga attagttgtt gtgttgattc       60

tc                                                                      62


<210>  51
<211>  53
<212>  DNA
<213>  ˹Уartificial sequence

<400>  51
gagaatcaac acaacaacta attcaagaga ttagttgttg tgttgattct ctt              53


<210>  52
<211>  59
<212>  DNA
<213>  ˹Уartificial sequence

<400>  52
caccgttctc cgaacgtgtc acgtcaagag attacgtgac acgttcggag aattttttg        59


<210>  53
<211>  59
<212>  DNA
<213>  ˹Уartificial sequence

<400>  53
agctcaaaaa attctccgaa cgtgtcacgt aatctcttga cgtgacacgt tcggagaac        59


<210>  54
<211>  50
<212>  DNA
<213>  ˹Уartificial sequence

<400>  54
gttctccgaa cgtgtcacgt caagagatta cgtgacacgt tcggagaatt                  50


