                         SEQUENCE LISTING

<110>  PTC Therapeutics
       University of South Florida
       Weeber, Edwin
       Kim, Min Jung
       Cao, Liangxian
       Arulanandam, Antonio
       Nash, Kevin
 
<120>  VECTOR AND METHOD FOR TREATING ANGELMAN SYNDROME

<130>  P1550-WO

<150>  62/821,442
<151>  2019-03-21

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  6619
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid


<220>
<221>  misc_feature
<222>  (1)..(6619)
<223>  pTR-UphUBE3 plasmid

<400>  1
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc tgaattcgcg atcgcttaat taaggccggc      180

cggcctccgc gccgggtttt ggcgcctccc gcgggcgccc ccctcctcac ggcgagcgct      240

gccacgtcag acgaagggcg cagcgagcgt cctgatcctt ccgcccggac gctcaggaca      300

gcggcccgct gctcataaga ctcggcctta gaaccccagt atcagcagaa ggacatttta      360

ggacgggact tgggtgactc tagggcactg gttttctttc cagagagcgg aacaggcgag      420

gaaaagtagt cccttctcgg cgattctgcg gagggatctc cgtggggcgg tgaacgccga      480

tgattatata aggacgcgcc gggtgtggca cagctagttc cgtcgcagcc gggatttggg      540

tcgcggttct tgtttgtgga tcgctgtgat cgtcacttgg tgagtagcgg gctgctgggc      600

tgggtacgtg cgctcggggt tggcgagtgt gttttgtgaa gttttttagg caccttttga      660

aatgtaatca tttgggtcaa tatgtaattt tcagtgttag actagtaaat tgtccgctaa      720

attctggccg tttttggctt ttttgttaga cgaagcttac cggtccacca tgaagcgagc      780

agctgcaaag catctaatag aacgctacta ccaccagtta actgagggct gtggaaatga      840

agcctgcacg aatgagtttt gtgcttcctg tccaactttt cttcgtatgg ataataatgc      900

agcagctatt aaagccctcg agctttataa gattaatgca aaactctgtg atcctcatcc      960

ctccaagaaa ggagcaagct cagcttacct tgagaactcg aaaggtgccc ccaacaactc     1020

ctgctctgag ataaaaatga acaagaaagg cgctagaatt gattttaaag atgtgactta     1080

cttaacagaa gagaaggtat atgaaattct tgaattatgt agagaaagag aggattattc     1140

ccctttaatc cgtgttattg gaagagtttt ttctagtgct gaggcattgg tacagagctt     1200

ccggaaagtt aaacaacaca ccaaggaaga actgaaatct cttcaagcaa aagatgaaga     1260

caaagatgaa gatgaaaagg aaaaagctgc atgttctgct gctgctatgg aagaagactc     1320

agaagcatct tcctcaagga taggtgatag ctcacaggga gacaacaatt tgcaaaaatt     1380

aggccctgat gatgtgtctg tggatattga tgccattaga agggtctaca ccagattgct     1440

ctctaatgaa aaaattgaaa ctgcctttct caatgcactt gtatatttgt cacctaacgt     1500

ggaatgtgac ttgacgtatc acaatgtata ctctcgagat cctaattatc tgaatttgtt     1560

cattatcgta atggagaata gaaatctcca cagtcctgaa tatctggaaa tggctttgcc     1620

attattttgc aaagcgatga gcaagctacc ccttgcagcc caaggaaaac tgatcagact     1680

gtggtctaaa tacaatgcag accagattcg gagaatgatg gagacatttc agcaacttat     1740

tacttataaa gtcataagca atgaatttaa cagtcgaaat ctagtgaatg atgatgatgc     1800

cattgttgct gcttcgaagt gcttgaaaat ggtttactat gcaaatgtag tgggagggga     1860

agtggacaca aatcacaatg aagaagatga tgaagagccc atccctgagt ccagcgagct     1920

gacacttcag gaacttttgg gagaagaaag aagaaacaag aaaggtcctc gagtggaccc     1980

cctggaaact gaacttggtg ttaaaaccct ggattgtcga aaaccactta tcccttttga     2040

agagtttatt aatgaaccac tgaatgaggt tctagaaatg gataaagatt atactttttt     2100

caaagtagaa acagagaaca aattctcttt tatgacatgt ccctttatat tgaatgctgt     2160

cacaaagaat ttgggattat attatgacaa tagaattcgc atgtacagtg aacgaagaat     2220

cactgttctc tacagcttag ttcaaggaca gcagttgaat ccatatttga gactcaaagt     2280

tagacgtgac catatcatag atgatgcact tgtccggcta gagatgatcg ctatggaaaa     2340

tcctgcagac ttgaagaagc agttgtatgt ggaatttgaa ggagaacaag gagttgatga     2400

gggaggtgtt tccaaagaat tttttcagct ggttgtggag gaaatcttca atccagatat     2460

tggtatgttc acatacgatg aatctacaaa attgttttgg tttaatccat cttcttttga     2520

aactgagggt cagtttactc tgattggcat agtactgggt ctggctattt acaataactg     2580

tatactggat gtacattttc ccatggttgt ctacaggaag ctaatgggga aaaaaggaac     2640

ttttcgtgac ttgggagact ctcacccagt tctatatcag agtttaaaag atttattgga     2700

gtatgaaggg aatgtggaag atgacatgat gatcactttc cagatatcac agacagatct     2760

ttttggtaac ccaatgatgt atgatctaaa ggaaaatggt gataaaattc caattacaaa     2820

tgaaaacagg aaggaatttg tcaatcttta ttctgactac attctcaata aatcagtaga     2880

aaaacagttc aaggcttttc ggagaggttt tcatatggtg accaatgaat ctcccttaaa     2940

gtacttattc agaccagaag aaattgaatt gcttatatgt ggaagccgga atctagattt     3000

ccaagcacta gaagaaacta cagaatatga cggtggctat accagggact ctgttctgat     3060

tagggagttc tgggaaatcg ttcattcatt tacagatgaa cagaaaagac tcttcttgca     3120

gtttacaacg ggcacagaca gagcacctgt gggaggacta ggaaaattaa agatgattat     3180

agccaaaaat ggcccagaca cagaaaggtt acctacatct catacttgct ttaatgtgct     3240

tttacttccg gaatactcaa gcaaagaaaa acttaaagag agattgttga aggccatcac     3300

gtatgccaaa ggatttggca tgctgtaagc tagccccggg atgcatatcg atgtcgacta     3360

gagctcgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct     3420

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     3480

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     3540

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggag agatctagga     3600

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgc     3660

ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc     3720

gcgcagagag ggagtggcca accccccccc ccccccccct gcaggccagc tggcgtaata     3780

gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg tagcctgaat ggcgaatggc     3840

gcgacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga     3900

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg     3960

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat     4020

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg     4080

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata     4140

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt     4200

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat     4260

ttaacgcgaa ttttaacaaa atattaacgt ttacaatttc ctgatgcggt attttctcct     4320

tacgcatctg tgcggtattt cacaccgcat atggtgcact ctcagtacaa tctgctctga     4380

tgccgcatag ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc     4440

ttgtctgctc ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg     4500

tcagaggttt tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct     4560

atttttatag gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg     4620

gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc     4680

gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag     4740

tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt     4800

tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt     4860

gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga     4920

acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat     4980

tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga     5040

gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag     5100

tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg     5160

accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg     5220

ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt     5280

agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg     5340

gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc     5400

ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg     5460

tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac     5520

ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact     5580

gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa     5640

acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa     5700

aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg     5760

atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc     5820

gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac     5880

tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca     5940

ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt     6000

ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc     6060

ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg     6120

aacgacctac accgaactga gatacctaca gcgtgagcat tgagaaagcg ccacgcttcc     6180

cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac     6240

gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct     6300

ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc     6360

cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt     6420

tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac     6480

cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg     6540

cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctgggctgc     6600

aggggggggg ggggggggg                                                  6619


<210>  2
<211>  3744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid sequence (ITR-ITR sequence of pTR-UphUbe)


<220>
<221>  misc_feature
<222>  (1)..(3744)
<223>  ITR-ITR SEQUENCE OF pTR-UphUBE3

<400>  2
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc tgaattcgcg atcgcttaat taaggccggc      180

cggcctccgc gccgggtttt ggcgcctccc gcgggcgccc ccctcctcac ggcgagcgct      240

gccacgtcag acgaagggcg cagcgagcgt cctgatcctt ccgcccggac gctcaggaca      300

gcggcccgct gctcataaga ctcggcctta gaaccccagt atcagcagaa ggacatttta      360

ggacgggact tgggtgactc tagggcactg gttttctttc cagagagcgg aacaggcgag      420

gaaaagtagt cccttctcgg cgattctgcg gagggatctc cgtggggcgg tgaacgccga      480

tgattatata aggacgcgcc gggtgtggca cagctagttc cgtcgcagcc gggatttggg      540

tcgcggttct tgtttgtgga tcgctgtgat cgtcacttgg tgagtagcgg gctgctgggc      600

tgggtacgtg cgctcggggt tggcgagtgt gttttgtgaa gttttttagg caccttttga      660

aatgtaatca tttgggtcaa tatgtaattt tcagtgttag actagtaaat tgtccgctaa      720

attctggccg tttttggctt ttttgttaga cgaagcttac cggtccacca tgaagcgagc      780

agctgcaaag catctaatag aacgctacta ccaccagtta actgagggct gtggaaatga      840

agcctgcacg aatgagtttt gtgcttcctg tccaactttt cttcgtatgg ataataatgc      900

agcagctatt aaagccctcg agctttataa gattaatgca aaactctgtg atcctcatcc      960

ctccaagaaa ggagcaagct cagcttacct tgagaactcg aaaggtgccc ccaacaactc     1020

ctgctctgag ataaaaatga acaagaaagg cgctagaatt gattttaaag atgtgactta     1080

cttaacagaa gagaaggtat atgaaattct tgaattatgt agagaaagag aggattattc     1140

ccctttaatc cgtgttattg gaagagtttt ttctagtgct gaggcattgg tacagagctt     1200

ccggaaagtt aaacaacaca ccaaggaaga actgaaatct cttcaagcaa aagatgaaga     1260

caaagatgaa gatgaaaagg aaaaagctgc atgttctgct gctgctatgg aagaagactc     1320

agaagcatct tcctcaagga taggtgatag ctcacaggga gacaacaatt tgcaaaaatt     1380

aggccctgat gatgtgtctg tggatattga tgccattaga agggtctaca ccagattgct     1440

ctctaatgaa aaaattgaaa ctgcctttct caatgcactt gtatatttgt cacctaacgt     1500

ggaatgtgac ttgacgtatc acaatgtata ctctcgagat cctaattatc tgaatttgtt     1560

cattatcgta atggagaata gaaatctcca cagtcctgaa tatctggaaa tggctttgcc     1620

attattttgc aaagcgatga gcaagctacc ccttgcagcc caaggaaaac tgatcagact     1680

gtggtctaaa tacaatgcag accagattcg gagaatgatg gagacatttc agcaacttat     1740

tacttataaa gtcataagca atgaatttaa cagtcgaaat ctagtgaatg atgatgatgc     1800

cattgttgct gcttcgaagt gcttgaaaat ggtttactat gcaaatgtag tgggagggga     1860

agtggacaca aatcacaatg aagaagatga tgaagagccc atccctgagt ccagcgagct     1920

gacacttcag gaacttttgg gagaagaaag aagaaacaag aaaggtcctc gagtggaccc     1980

cctggaaact gaacttggtg ttaaaaccct ggattgtcga aaaccactta tcccttttga     2040

agagtttatt aatgaaccac tgaatgaggt tctagaaatg gataaagatt atactttttt     2100

caaagtagaa acagagaaca aattctcttt tatgacatgt ccctttatat tgaatgctgt     2160

cacaaagaat ttgggattat attatgacaa tagaattcgc atgtacagtg aacgaagaat     2220

cactgttctc tacagcttag ttcaaggaca gcagttgaat ccatatttga gactcaaagt     2280

tagacgtgac catatcatag atgatgcact tgtccggcta gagatgatcg ctatggaaaa     2340

tcctgcagac ttgaagaagc agttgtatgt ggaatttgaa ggagaacaag gagttgatga     2400

gggaggtgtt tccaaagaat tttttcagct ggttgtggag gaaatcttca atccagatat     2460

tggtatgttc acatacgatg aatctacaaa attgttttgg tttaatccat cttcttttga     2520

aactgagggt cagtttactc tgattggcat agtactgggt ctggctattt acaataactg     2580

tatactggat gtacattttc ccatggttgt ctacaggaag ctaatgggga aaaaaggaac     2640

ttttcgtgac ttgggagact ctcacccagt tctatatcag agtttaaaag atttattgga     2700

gtatgaaggg aatgtggaag atgacatgat gatcactttc cagatatcac agacagatct     2760

ttttggtaac ccaatgatgt atgatctaaa ggaaaatggt gataaaattc caattacaaa     2820

tgaaaacagg aaggaatttg tcaatcttta ttctgactac attctcaata aatcagtaga     2880

aaaacagttc aaggcttttc ggagaggttt tcatatggtg accaatgaat ctcccttaaa     2940

gtacttattc agaccagaag aaattgaatt gcttatatgt ggaagccgga atctagattt     3000

ccaagcacta gaagaaacta cagaatatga cggtggctat accagggact ctgttctgat     3060

tagggagttc tgggaaatcg ttcattcatt tacagatgaa cagaaaagac tcttcttgca     3120

gtttacaacg ggcacagaca gagcacctgt gggaggacta ggaaaattaa agatgattat     3180

agccaaaaat ggcccagaca cagaaaggtt acctacatct catacttgct ttaatgtgct     3240

tttacttccg gaatactcaa gcaaagaaaa acttaaagag agattgttga aggccatcac     3300

gtatgccaaa ggatttggca tgctgtaagc tagccccggg atgcatatcg atgtcgacta     3360

gagctcgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct     3420

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     3480

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     3540

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggag agatctagga     3600

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgc     3660

ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc     3720

gcgcagagag ggagtggcca accc                                            3744


<210>  3
<211>  10893
<212>  DNA
<213>  Homo sapiens


<220>
<221>  gene
<222>  (1)..(10893)
<223>  UBE3A genomic sequence

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (340)..(340)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1145)..(1145)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1180)..(1180)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1257)..(1257)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5410)..(5410)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7624)..(7624)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7644)..(7644)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7647)..(7647)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7741)..(7741)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7836)..(7836)
<223>  n is a, c, g, or t

<400>  3
ggagtagttt actgagccac taatctaaag tttaatactg tgagtgaata ccagtgagta       60

cctttgttaa tgtggataac caatacttgg ctataggaag ttttttagtt gtgtgtttta      120

tnacacgtat ttgactttgt gaataattat ggcttataat ggcttgtctg ttggtatcta      180

tgtatagcgt ttacagtttc ctttaaaaaa catgcattga gttttttaat agtccaaccc      240

ttaaaataaa tgtgttgtat ggccacctga tctgaccact ttctttcatg ttgacatctt      300

taattttaaa actgttttat ttagtgctta aatcttgttn acaaaattgt cttcctaagt      360

aatatgtcta cctttttttt tggaatatgg aatattttgc taactgtttc tcaattgcat      420

tttacagatc aggagaacct cagtctgacg acattgaagc tagccgaatg taagtgtaac      480

ttggttgaga ctgtggttct tattttgagt tgccctagac tgctttaaat tacgtcacat      540

tatttggaaa taatttctgg ttaaaagaaa ggaatcattt agcagtaaat gggagatagg      600

aacataccta ctttttttcc tatcagataa ctctaaacct cggtaacagt ttactaggtt      660

tctactacta gatagataaa tgcacacgcc taaattctta gtctttttgc ttccctggta      720

gcagttgtag ggaaataggg aggttgagga aagagtttaa cagtctcaac gcctaccata      780

tttaaggcat caagtactat gttatagata cagagatgcg taataattag ttttcaccct      840

acagaaattt atattatact caagagtgaa agatgcagaa gcaaataatt tcagtcactg      900

aggtagaatg gtatccaaaa tacaatagta acatgaagga gtactggagt accaggtatg      960

caataggaat ctagtgtaga tggcagggaa gtaagagtgg ccaggaaatg ctaagttcag     1020

tcttgaaatg tgactgggaa tcaggcagct atcaactata agtcaaatgt ttacaagctg     1080

ttaaaaatga aatactgatt atgtaaaaga aaaccggatt gatgctttaa atagactcat     1140

tttcntaatg ctaattttta aaatgataga atcctacaan tcttagctgt aaaccttgtg     1200

atttttcagc tgttgtacta aacaacttaa gcacatatac catcagacaa gcccccntcc     1260

ccccttttaa accaaaggaa tgtatactct gttaatacag tcagtaagca ttgacattct     1320

ttatcataat atcctagaaa atatttatta actatttcac tagtcaggag ttgtggtaaa     1380

tagtgcatct ccattttcta cttctcatct tcatacacag gttaatcact tcagtgcttg     1440

actaactttt gccttgatga tatgttgagc tttgtacttg agagctgtac taatcactgt     1500

gcttattgtt tgaatgtttg gtacaggaag cgagcagctg caaagcatct aatagaacgc     1560

tactaccacc agttaactga gggctgtgga aatgaagcct gcacgaatga gttttgtgct     1620

tcctgtccaa cttttcttcg tatggataat aatgcagcag ctattaaagc cctcgagctt     1680

tataagatta atgcaaaact ctgtgatcct catccctcca agaaaggagc aagctcagct     1740

taccttgaga actcgaaagg tgcccccaac aactcctgct ctgagataaa aatgaacaag     1800

aaaggcgcta gaattgattt taaaggtaag atgttttatt ttcaattgag aattgttgcc     1860

tgaaaaccat gtgggagatt taaatgtatt agtttttatt tgttttttct tctgtgacat     1920

aaagacattt tgatatcgta gaaccaattt tttattgtgg taacggacag gaataataac     1980

tacattttac aggtctaatc attgctaatt agaagcagat catatgccaa aagttcattt     2040

gttaatagat tgatttgaac tttttaaaat tcttaggaaa aatgtattaa gtggtagtga     2100

atctccaaaa ctatttaaga gctgtattat gattaatcag tacatgacat attggttcat     2160

atttataatt aaagctatac attaatagat atcttgatta taaagaaagt ttaaactcat     2220

gatcttatta agagttatac attgttgaaa gaatgtaaaa gcatgggtga ggtcattggt     2280

ataggtaggt agttcattga aaaaaatagg taagcattaa attttgtttg ctgaatctaa     2340

gtattagata ctttaagagt tgtatatcat aaatgatatt gagcctagaa tgtttggctg     2400

ttttactttt agaacttttt gcaacagagt aaacatacat attatgaaaa taaatgttct     2460

cttttttcct ctgattttct agatgtgact tacttaacag aagagaaggt atatgaaatt     2520

cttgaattat gtagagaaag agaggattat tcccctttaa tccgtgttat tggaagagtt     2580

ttttctagtg ctgaggcatt ggtacagagc ttccggaaag ttaaacaaca caccaaggaa     2640

gaactgaaat ctcttcaagc aaaagatgaa gacaaagatg aagatgaaaa ggaaaaagct     2700

gcatgttctg ctgctgctat ggaagaagac tcagaagcat cttcctcaag gataggtgat     2760

agctcacagg gagacaacaa tttgcaaaaa ttaggccctg atgatgtgtc tgtggatatt     2820

gatgccatta gaagggtcta caccagattg ctctctaatg aaaaaattga aactgccttt     2880

ctcaatgcac ttgtatattt gtcacctaac gtggaatgtg acttgacgta tcacaatgta     2940

tactctcgag atcctaatta tctgaatttg ttcattatcg taatggagaa tagaaatctc     3000

cacagtcctg aatatctgga aatggctttg ccattatttt gcaaagcgat gagcaagcta     3060

ccccttgcag cccaaggaaa actgatcaga ctgtggtcta aatacaatgc agaccagatt     3120

cggagaatga tggagacatt tcagcaactt attacttata aagtcataag caatgaattt     3180

aacagtcgaa atctagtgaa tgatgatgat gccattgttg ctgcttcgaa gtgcttgaaa     3240

atggtttact atgcaaatgt agtgggaggg gaagtggaca caaatcacaa tgaagaagat     3300

gatgaagagc ccatccctga gtccagcgag ctgacacttc aggaactttt gggagaagaa     3360

agaagaaaca agaaaggtcc tcgagtggac cccctggaaa ctgaacttgg tgttaaaacc     3420

ctggattgtc gaaaaccact tatccctttt gaagagttta ttaatgaacc actgaatgag     3480

gttctagaaa tggataaaga ttatactttt ttcaaagtag aaacagagaa caaattctct     3540

tttatgacat gtccctttat attgaatgct gtcacaaaga atttgggatt atattatgac     3600

aatagaattc gcatgtacag tgaacgaaga atcactgttc tctacagctt agttcaagga     3660

cagcagttga atccatattt gagactcaaa gttagacgtg accatatcat agatgatgca     3720

cttgtccggg taagttgggc tgctagatta aaaacctaat aatggggata tcatgataca     3780

gttcagtgaa ttcattttaa aagtgactga aaaaaatgat accatatagc ataggaacac     3840

atggacattt ctgatcttat ataagtatta tacttttgtt gttcctgtgc aagtttatag     3900

atgtgttcta caaagtatcg gttgtattat ataatggtca tgctatcttt gaaaaagaat     3960

gggttttcta aatcttgaaa actaaatcca aagtttcttt cattcagaag agaatagagt     4020

gttggacaaa gaccagaaca agagaaatgt ggagataccc aataataagt gtggatgtgc     4080

agtcttgaac tgggagtaat ggtacagtaa aaccatacca taaaattata ggtagtgtcc     4140

aaaaaattcc atcgtgtaaa attcagagtt gcattattgt ggacttgaag aagcagttgt     4200

atgtgggacg gtatcgataa gcttgatatc gaattcctgc agcccggggg atccactagt     4260

gtggtaatta atactaagtc ttactgtgag agaccataaa ctgctttagt attcagtgta     4320

tttttcttaa ttgaaatatt taacttatga cttagtagat actaagactt aacccttgag     4380

tttctattct aataaaggac tactaatgaa caattttgag gttagacctc tactccattg     4440

tttttgctga aatgatttag ctgcttttcc atgtcctgtg tagtccagac ttaacacaca     4500

agtaataaaa tcttaattaa ttgtatgtta atttcataac aaatcagtaa agttagcttt     4560

ttactatgct agtgtctgtt ttgtgtctgt ctttttgatt atctttaaga ctgaatcttt     4620

gtcttcactg gctttttatc agtttgcttt ctgtttccat ttacatacaa aaagtcaaaa     4680

atttgtattt gtttcctaat cctactcctt gtttttattt tgtttttttc ctgatactag     4740

caatcatctt cttttcatgt ttatcttttc aatcactagc tagagatgat cgctatggaa     4800

aatcctgcag acttgaagaa gcagttgtat gtggaatttg aaggagaaca aggagttgat     4860

gagggaggtg tttccaaaga attttttcag ctggttgtgg aggaaatctt caatccagat     4920

attggtaaat acattagtaa tgtgattatg gtgtcgtatc atcttttgag ttagttattt     4980

gtttatctta ctttgtaaat attttcagct atgaagagca gcaaaagaag gatttggtat     5040

ggattaccca gaatcacaca tcatgactga atttgtaggt tttaggaact gatttgtatc     5100

actaatttat tcaaattctt ttatttctta gaaggaatat tctaatgaag gaaattatct     5160

ctttggtaaa ctgaattgaa agcactttag aatggtatat tggaacagtt ggagggattt     5220

ctttgctttt tgttgtctaa aaccatcatc aaactcacgg ttttcctgac ctgtgaactt     5280

caaagaacaa tggtttgaag agtattgaga gactgtctca caagtatgtc atgctcaaag     5340

ttcagaaaca ctagctgata tcacattaat taggtttatt tgctataaga tttcttgggg     5400

cttaatatan gtagtgttcc cccaaacttt ttgaactcca gaactctttt ctgccctaac     5460

agtagctact caggagctga ggcaggagaa ttgtttgaac ctaggaggca gaggttgcag     5520

tgagctgaga tcgtgccact ccagcccacc cctgggtaac agagcgagac tccatctcaa     5580

agaaaaaaat gaaaaattgt tttcaaaaat agtacgtgtg gtacagatat aagtaattat     5640

atttttataa atgaaacact ttggaaatgt agccattttt tgttttttta tgtttatttt     5700

tcagctatgg gtggataaag catgaatata acttttctta tgtgttagta gaaaattaga     5760

aagcttgaat ttaattaacg tatttttcta cccgatgcca ccaaattact tactacttta     5820

ttcctttggc ttcataaaat tacatatcac cattcacccc aatttatagc agatatatgt     5880

ggacattgtt ttctcaagtg ctaatataat agaaatcaat gttgcatgcc taattacata     5940

tattttaaat gttttatatg cataattatt ttaagtttat atttgtatta ttcatcagtc     6000

cttaataaaa tacaaaagta atgtattttt aaaaatcatt tcttataggt atgttcacat     6060

acgatgaatc tacaaaattg ttttggttta atccatcttc ttttgaaact gagggtcagt     6120

ttactctgat tggcatagta ctgggtctgg ctatttacaa taactgtata ctggatgtac     6180

attttcccat ggttgtctac aggaagctaa tggggaaaaa aggaactttt cgtgacttgg     6240

gagactctca cccagtaagt tctttgtcat ttttttaatt cagtctctta gattttattt     6300

aaatgcaaaa atttaattta tgtcaaaatt ttaaagtttt tgtttagaat ctttgttgat     6360

actcttatca ataagataaa aatgttttaa tctgaccgaa gtaccagaaa cacttaaaaa     6420

ctcaaagggg gacattttta tatattgctg tcagcacgaa gctttcgtaa gattgatttc     6480

atagagaagt gtttctaaac attttgtttg tgttttagtg aaatcttaag agataggtaa     6540

aaatcagagt agccctggct aagggtcttg gtagttacaa cgagtgtgcc tgctcctacc     6600

acccccaccc ccaccttgag acaccacaga atttctcata gagcacagtg tgaattctat     6660

tgctaaattg gtggtatggg gtttctcagc agagaatggg acatcacagt gactgacaat     6720

ctttctttta taggttggaa actatttggg ggactggagg gatactgtct acacttttta     6780

caatttttat tgataagatt tttgttgtct tctaagaaga gtgatataaa ttatttgttg     6840

tattttgtag ttctatggtg gcctcaattt accatttctg gttgctaggt tctatatcag     6900

agtttaaaag atttattgga gtatgaaggg aatgtggaag atgacatgat gatcactttc     6960

cagatatcac agacagatct ttttggtaac ccaatgatgt atgatctaaa ggaaaatggt     7020

gataaaattc caattacaaa tgaaaacagg aaggtaataa atgtttttat gtcacatttt     7080

gtctcttcat taacactttc aaagcatgta tgcttataat ttttaaagaa gtatctaata     7140

tagtctgtac aaaaaaaaaa caagtaacta agtttatgta aatgctagag tccacttttc     7200

taaatcttgg atataagttg gtatgaaagc acacagttgg gcactaaagc cccttttaga     7260

gaaagaggac atgaagcagg agatagttaa tagctaagtg tggttgtagt ataaagcaag     7320

aagcagggtg tttcttgtat taagctgtaa gcaggaacct catgattaag gtctttatca     7380

cagaacaaat aaaaattaca tttaatttac acatgtatat cctgtttgtg ataaaaatac     7440

atttctgaaa agtatacttt acgtcagatt tgggttctat tgactaaaat gtgttcatcg     7500

ggaatgggaa taacccagaa cataacaagc aaaaaattat gacaaatata tagtatacct     7560

ttaagaaaca tgtttatatt gatataattt tttgattaaa tattatacac actaagggta     7620

caangcacat tttcctttta tganttngat acagtagttt atgtgtcagt cagatacttc     7680

cacatttttg ctgaactgga tacagtaagc agcttaccaa atattctatg gtagaaaact     7740

nggacttcct ggtttgctta aatcaaatat attgtactct cttaaaacgg ttggcattta     7800

taaatagatg gatacatggt ttaaatgtgt ctgttnacat acctagttga gagaacctaa     7860

agaattttct gcgtctccag catttatatt cagttctgtt taatacatta tcgaaattga     7920

catttataag tatgacagtt ttgtgtatat ggccttttca tagcttaata ttggctgtaa     7980

cagagaattg tgaaattgta agaagtagtt ttctttgtag gtgtaaaatt gaatttttaa     8040

gaatattctt gacagtttta tgtatatggc cttttcatag cttaatattg gctataacag     8100

agaattgtga aattgttaag aagtaggtgt aaaattgaat ttttaagaat attcttgaat     8160

gtttttttct tggaaaaatt aaaaagctat gcagcccaat aacttgtgtt ttgtttgcat     8220

agcatattat aagaagttct tgtgattaat gttttctaca ggaatttgtc aatctttatt     8280

ctgactacat tctcaataaa tcagtagaaa aacagttcaa ggcttttcgg agaggttttc     8340

atatggtgac caatgaatct cccttaaagt acttattcag accagaagaa attgaattgc     8400

ttatatgtgg aagccgggta agaaagcagg tgtctgcaaa aagtcatgta tcgatttatt     8460

gtttgtaatg atacagtagt atagcagata actaagacat attttcttga atttgcagaa     8520

tctagatttc caagcactag aagaaactac agaatatgac ggtggctata ccagggactc     8580

tgttctgatt aggtgaggta cttagttctt cagaggaaga tttgattcac caaaggggtg     8640

tgtgattttg cttcagacct ttatctctag gtactaattc ccaaataagc aaactcacaa     8700

attgtcatct atatacttag atttgtattt gtaatataat caccattttt cagagctaat     8760

cttgtgattt atttcatgaa tgaagtgttg ttatatataa gtctcatgta atctcctgca     8820

tttggcgtat ggattatcta gtattcctca ctggttagag tatgcttact gctggttaga     8880

agataattaa aataaggcta ccatgtctgc aatttttcct ttcttttgaa ctctgcattt     8940

gtgaactgtt acatggcttc ccaggatcaa gcactttttg agtgaaatgg tagtctttta     9000

tttaattctt aagataatat gtccagatac atactagtat ttccatttta caccctaaaa     9060

aactaagccc tgaattctca cagaaagatg tagaggttcc cagttctatc tgcttttaaa     9120

caaatgccct tactactcta ctgtctactt ctgtgtacta catcatcgta tgtagttgtt     9180

tgcatttggg ccagttggtt ggggcagggg tctttttttc ttttgtccct taatctgtat     9240

cactttttcc tcccaaagtt gagttaaagg atgagtagac caggagaata aaggagaaag     9300

gataaataaa atatataccc aaaggcacct ggagttaatt tttccaaata ttcatttcag     9360

tctttttcaa ttcataggat tttgtctttt gctcattact gactgcataa tgtgattata     9420

ccatagttta aatagtcact tcctgttact acacacttgg gttttctcaa ttttttacta     9480

ttgtagtact aatattttac tatattgtaa tctaatccaa atttttacgt attcagagct     9540

gttcaggata aatttgcttg gaaattttta aatcaccaga agtgatacta tcctgataat     9600

taacttccaa gttgtctctt aatatagttt taatgcaaat cataagctta tgttagtacc     9660

agtcataatg aatgccaaac tgaaaccagt attgtatttt ttctcattag ggagttctgg     9720

gaaatcgttc attcatttac agatgaacag aaaagactct tcttgcagtt tacaacgggc     9780

acagacagag cacctgtggg aggactagga aaattaaaga tgattatagc caaaaatggc     9840

ccagacacag aaaggtaggt aattattaac ttgtgactgt atacctaccg aaaaccttgc     9900

attcctcgtc acatacatat gaactgtctt tatagtttct gagcacattc gtgattttat     9960

atacaaatcc ccaaatcata ttagacaatt gagaaaatac tttgctgtca ttgtgtgagg    10020

aaacttttaa gaaattgccc tagttaaaaa ttattatggg gctcacattg gtttggaatc    10080

aaattagtgt gattcattta cttttttgat tcccagcttg ttaattgaaa gccatataac    10140

atgatcatct atttagaatg gttacattga ggctcggaag attatcattt gattgtgcta    10200

gaatcctgtt atcaaatcat tttcttagtc atattgccag cagtgtttct aataagcatt    10260

taagagcaca cactttgcag tcttgtaaaa caggtttgag tattttctcc accttagagg    10320

aagttacttg acttctcagt gacctaacct ctaaagtgca tttactgatg tcctctctgt    10380

ggttttgttg tggaaagatt tagttaaatg aactgtaaga attcagtacc taaaatggta    10440

tctgttatgt agtaaaaact caatggatac agtatcttat catcgtcact agctttgagt    10500

aatttatagg ataaaggcaa cttggtagtt acacaacaaa aagtttatga tttgcattaa    10560

tgtatagttt gcattgcaga ccgtctcaac tatatacaat ctaaaaatag gagcatttaa    10620

ttctaagtgt atttcccatg acttacagtt ttcctgtttt tttccccttt tctctattta    10680

ggttacctac atctcatact tgctttaatg tgcttttact tccggaatac tcaagcaaag    10740

aaaaacttaa agagagattg ttgaaggcca tcacgtatgc caaaggattt ggcatgctgt    10800

aaaacaaaac aaaacaaaat aaaacaaaaa aaaggaagga aaaaaaaaga aaaaatttaa    10860

aaaattttaa aaatataacg agggataaat ttt                                 10893


<210>  4
<211>  852
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(852)
<223>  Human UBE3A Isoform 1

<400>  4

Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg Tyr Tyr His Gln 
1               5                   10                  15      


Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn Glu Phe Cys Ala 
            20                  25                  30          


Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala Ala Ala Ile Lys 
        35                  40                  45              


Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys Asp Pro His Pro 
    50                  55                  60                  


Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn Ser Lys Gly Ala 
65                  70                  75                  80  


Pro Asn Asn Ser Cys Ser Glu Ile Lys Met Asn Lys Lys Gly Ala Arg 
                85                  90                  95      


Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu Lys Val Tyr Glu 
            100                 105                 110         


Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser Pro Leu Ile Arg 
        115                 120                 125             


Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu Val Gln Ser Phe 
    130                 135                 140                 


Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu Gln Ala 
145                 150                 155                 160 


Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala Cys Ser 
                165                 170                 175     


Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg Ile Gly 
            180                 185                 190         


Asp Ser Ser Gln Gly Asp Asn Asn Leu Gln Lys Leu Gly Pro Asp Asp 
        195                 200                 205             


Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr Thr Arg Leu Leu 
    210                 215                 220                 


Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala Leu Val Tyr Leu 
225                 230                 235                 240 


Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr Ser Arg 
                245                 250                 255     


Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met Glu Asn Arg Asn 
            260                 265                 270         


Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe Cys Lys 
        275                 280                 285             


Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys Leu Ile Arg Leu 
    290                 295                 300                 


Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met Met Glu Thr Phe 
305                 310                 315                 320 


Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn Ser Arg 
                325                 330                 335     


Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys Cys Leu 
            340                 345                 350         


Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu Val Asp Thr Asn 
        355                 360                 365             


His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser Glu Leu 
    370                 375                 380                 


Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn Lys Lys Gly Pro 
385                 390                 395                 400 


Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys Thr Leu Asp Cys 
                405                 410                 415     


Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn Glu Pro Leu Asn 
            420                 425                 430         


Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val Glu Thr 
        435                 440                 445             


Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn Ala Val 
    450                 455                 460                 


Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met Tyr Ser 
465                 470                 475                 480 


Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln Gln Leu 
                485                 490                 495     


Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile Asp Asp 
            500                 505                 510         


Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala Asp Leu 
        515                 520                 525             


Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val Asp Glu 
    530                 535                 540                 


Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu Ile Phe 
545                 550                 555                 560 


Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser Thr Lys Leu Phe 
                565                 570                 575     


Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr Leu Ile 
            580                 585                 590         


Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys Ile Leu Asp Val 
        595                 600                 605             


His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys Gly Thr 
    610                 615                 620                 


Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr Gln Ser Leu Lys 
625                 630                 635                 640 


Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp Met Met Ile Thr 
                645                 650                 655     


Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met Tyr Asp 
            660                 665                 670         


Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn Arg Lys 
        675                 680                 685             


Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser Val Glu 
    690                 695                 700                 


Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met Val Thr Asn Glu 
705                 710                 715                 720 


Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu Leu Ile 
                725                 730                 735     


Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr Thr Glu 
            740                 745                 750         


Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile Arg Glu Phe Trp 
        755                 760                 765             


Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe Leu Gln 
    770                 775                 780                 


Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly Lys Leu 
785                 790                 795                 800 


Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu Pro Thr 
                805                 810                 815     


Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser Ser Lys 
            820                 825                 830         


Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala Lys Gly 
        835                 840                 845             


Phe Gly Met Leu 
    850         


<210>  5
<211>  2559
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2559)
<223>  UBE3Av1 cDNA

<400>  5
atgaagcgag cagctgcaaa gcatctaata gaacgctact accaccagtt aactgagggc       60

tgtggaaatg aagcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg      120

gataataatg cagcagctat taaagccctc gagctttata agattaatgc aaaactctgt      180

gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc gaaaggtgcc      240

cccaacaact cctgctctga gataaaaatg aacaagaaag gcgctagaat tgattttaaa      300

gatgtgactt acttaacaga agagaaggta tatgaaattc ttgaattatg tagagaaaga      360

gaggattatt cccctttaat ccgtgttatt ggaagagttt tttctagtgc tgaggcattg      420

gtacagagct tccggaaagt taaacaacac accaaggaag aactgaaatc tcttcaagca      480

aaagatgaag acaaagatga ggatgaaaag gaaaaagctg catgttctgc tgctgctatg      540

gaagaagact cagaagcatc ttcctcaagg ataggtgata gctcacaggg agacaacaat      600

ttgcaaaaat taggccctga tgatgtgtct gtggatattg atgccattag aagggtctac      660

accagattgc tctctaatga aaaaattgaa actgcctttc tcaatgcact tgtatatttg      720

tcacctaacg tggaatgtga cttgacgtat cacaatgtat actctcgaga tcctaattat      780

ctgaatttgt tcattatcgt aatggagaat agaaatctcc acagtcctga atatctggaa      840

atggctttgc cattattttg caaagcgatg agcaagctac cccttgcagc ccaaggaaaa      900

ctgatcagac tgtggtctaa atacaatgca gaccagattc ggagaatgat ggagacattt      960

cagcaactta ttacttataa agtcataagc aatgaattta acagtcgaaa tctagtgaat     1020

gatgatgatg ccattgttgc tgcttcgaag tgcttgaaaa tggtttacta tgcaaatgta     1080

gtgggagggg aagtggacac aaatcacaat gaagaagatg atgaagagcc catccctgag     1140

tccagcgagc tgacacttca ggaacttttg ggagaagaaa gaagaaacaa gaaaggtcct     1200

cgagtggacc ccctggaaac tgaacttggt gttaaaaccc tggattgtcg aaaaccactt     1260

atcccttttg aagagtttat taatgaacca ctgaatgagg ttctagaaat ggataaagat     1320

tatacttttt tcaaagtaga aacagagaac aaattctctt ttatgacatg tccctttata     1380

ttgaatgctg tcacaaagaa tttgggatta tattatgaca atagaattcg catgtacagt     1440

gaacgaagaa tcactgttct ctacagctta gttcaaggac agcagttgaa tccatatttg     1500

agactcaaag ttagacgtga ccatatcata gatgatgcac ttgtccggct agagatgatc     1560

gctatggaaa atcctgcaga cttgaagaag cagttgtatg tggaatttga aggagaacaa     1620

ggagttgatg agggaggtgt ttccaaagaa ttttttcagc tggttgtgga ggaaatcttc     1680

aatccagata ttggtatgtt cacatacgat gaatctacaa aattgttttg gtttaatcca     1740

tcttcttttg aaactgaggg tcagtttact ctgattggca tagtactggg tctggctatt     1800

tacaataact gtatactgga tgtacatttt cccatggttg tctacaggaa gctaatgggg     1860

aaaaaaggaa cttttcgtga cttgggagac tctcacccag ttctatatca gagtttaaaa     1920

gatttattgg agtatgaagg gaatgtggaa gatgacatga tgatcacttt ccagatatca     1980

cagacagatc tttttggtaa cccaatgatg tatgatctaa aggaaaatgg tgataaaatt     2040

ccaattacaa atgaaaacag gaaggaattt gtcaatcttt attctgacta cattctcaat     2100

aaatcagtag aaaaacagtt caaggctttt cggagaggtt ttcatatggt gaccaatgaa     2160

tctcccttaa agtacttatt cagaccagaa gaaattgaat tgcttatatg tggaagccgg     2220

aatctagatt tccaagcact agaagaaact acagaatatg acggtggcta taccagggac     2280

tctgttctga ttagggagtt ctgggaaatc gttcattcat ttacagatga acagaaaaga     2340

ctcttcttgc agtttacaac gggcacagac agagcacctg tgggaggact aggaaaatta     2400

aagatgatta tagccaaaaa tggcccagac acagaaaggt tacctacatc tcatacttgc     2460

tttaatgtgc ttttacttcc ggaatactca agcaaagaaa aacttaaaga gagattgttg     2520

aaggccatca cgtatgccaa aggatttggc atgctgtaa                            2559


<210>  6
<211>  5276
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(5276)
<223>  UBE3Av2 cDNA

<400>  6
agccagtcct cccgtcttgc gccgcggccg cgagatccgt gtgtctccca agatggtggc       60

gctgggctcg gggtgactac aggagacgac ggggcctttt cccttcgcca ggacccgaca      120

caccaggctt cgctcgctcg cgcacccctc cgccgcgtag ccatccgcca gcgcgggcgc      180

ccgccatccg ccgcctactt acgcttcacc tctgccgacc cggcgcgctc ggctgcgggc      240

ggcggcgcct ccttcggctc ctcctcggaa tagctcgcgg cctgtagccc ctggcaggag      300

ggcccctcag ccccccggtg tggacaggca gcggcggctg gcgacgaacg ccgggatttc      360

ggcggccccg gcgctccctt tcccggcctc gttttccgga taaggaagcg cgggtcccgc      420

atgagccccg gcggtggcgg cagcgaaaga gaacgaggcg gtggcgggcg gaggcggcgg      480

gcgagggcga ctacgaccag tgaggcggcc gccgcagccc aggcgcgggg gcgacgacag      540

gttaaaaatc tgtaagagcc tgattttaga attcaccagc tcctcagaag tttggcgaaa      600

tatgagttat taagcctacg ctcagatcaa ggtagcagct agactggtgt gacaacctgt      660

ttttaatcag tgactcaaag ctgtgatcac cctgatgtca ccgaatggcc acagcttgta      720

aaagagagtt acagtggagg taaaaggagt ggcttgcagg atggagaagc tgcaccagtg      780

ttattggaaa tcaggagaac ctcagtctga cgacattgaa gctagccgaa tgaagcgagc      840

agctgcaaag catctaatag aacgctacta ccaccagtta actgagggct gtggaaatga      900

agcctgcacg aatgagtttt gtgcttcctg tccaactttt cttcgtatgg ataataatgc      960

agcagctatt aaagccctcg agctttataa gattaatgca aaactctgtg atcctcatcc     1020

ctccaagaaa ggagcaagct cagcttacct tgagaactcg aaaggtgccc ccaacaactc     1080

ctgctctgag ataaaaatga acaagaaagg cgctagaatt gattttaaag atgtgactta     1140

cttaacagaa gagaaggtat atgaaattct tgaattatgt agagaaagag aggattattc     1200

ccctttaatc cgtgttattg gaagagtttt ttctagtgct gaggcattgg tacagagctt     1260

ccggaaagtt aaacaacaca ccaaggaaga actgaaatct cttcaagcaa aagatgaaga     1320

caaagatgaa gatgaaaagg aaaaagctgc atgttctgct gctgctatgg aagaagactc     1380

agaagcatct tcctcaagga taggtgatag ctcacaggga gacaacaatt tgcaaaaatt     1440

aggccctgat gatgtgtctg tggatattga tgccattaga agggtctaca ccagattgct     1500

ctctaatgaa aaaattgaaa ctgcctttct caatgcactt gtatatttgt cacctaacgt     1560

ggaatgtgac ttgacgtatc acaatgtata ctctcgagat cctaattatc tgaatttgtt     1620

cattatcgta atggagaata gaaatctcca cagtcctgaa tatctggaaa tggctttgcc     1680

attattttgc aaagcgatga gcaagctacc ccttgcagcc caaggaaaac tgatcagact     1740

gtggtctaaa tacaatgcag accagattcg gagaatgatg gagacatttc agcaacttat     1800

tacttataaa gtcataagca atgaatttaa cagtcgaaat ctagtgaatg atgatgatgc     1860

cattgttgct gcttcgaagt gcttgaaaat ggtttactat gcaaatgtag tgggagggga     1920

agtggacaca aatcacaatg aagaagatga tgaagagccc atccctgagt ccagcgagct     1980

gacacttcag gaacttttgg gagaagaaag aagaaacaag aaaggtcctc gagtggaccc     2040

cctggaaact gaacttggtg ttaaaaccct ggattgtcga aaaccactta tcccttttga     2100

agagtttatt aatgaaccac tgaatgaggt tctagaaatg gataaagatt atactttttt     2160

caaagtagaa acagagaaca aattctcttt tatgacatgt ccctttatat tgaatgctgt     2220

cacaaagaat ttgggattat attatgacaa tagaattcgc atgtacagtg aacgaagaat     2280

cactgttctc tacagcttag ttcaaggaca gcagttgaat ccatatttga gactcaaagt     2340

tagacgtgac catatcatag atgatgcact tgtccggcta gagatgatcg ctatggaaaa     2400

tcctgcagac ttgaagaagc agttgtatgt ggaatttgaa ggagaacaag gagttgatga     2460

gggaggtgtt tccaaagaat tttttcagct ggttgtggag gaaatcttca atccagatat     2520

tggtatgttc acatacgatg aatctacaaa attgttttgg tttaatccat cttcttttga     2580

aactgagggt cagtttactc tgattggcat agtactgggt ctggctattt acaataactg     2640

tatactggat gtacattttc ccatggttgt ctacaggaag ctaatgggga aaaaaggaac     2700

ttttcgtgac ttgggagact ctcacccagt tctatatcag agtttaaaag atttattgga     2760

gtatgaaggg aatgtggaag atgacatgat gatcactttc cagatatcac agacagatct     2820

ttttggtaac ccaatgatgt atgatctaaa ggaaaatggt gataaaattc caattacaaa     2880

tgaaaacagg aaggaatttg tcaatcttta ttctgactac attctcaata aatcagtaga     2940

aaaacagttc aaggcttttc ggagaggttt tcatatggtg accaatgaat ctcccttaaa     3000

gtacttattc agaccagaag aaattgaatt gcttatatgt ggaagccgga atctagattt     3060

ccaagcacta gaagaaacta cagaatatga cggtggctat accagggact ctgttctgat     3120

tagggagttc tgggaaatcg ttcattcatt tacagatgaa cagaaaagac tcttcttgca     3180

gtttacaacg ggcacagaca gagcacctgt gggaggacta ggaaaattaa agatgattat     3240

agccaaaaat ggcccagaca cagaaaggtt acctacatct catacttgct ttaatgtgct     3300

tttacttccg gaatactcaa gcaaagaaaa acttaaagag agattgttga aggccatcac     3360

gtatgccaaa ggatttggca tgctgtaaaa caaaacaaaa caaaataaaa caaaaaaaag     3420

gaaggaaaaa aaaagaaaaa atttaaaaaa ttttaaaaat ataacgaggg ataaattttt     3480

ggtggtgata gtgtcccagt acaaaaaggc tgtaagatag tcaaccacag tagtcaccta     3540

tgtctgtgcc tcccttcttt attggggaca tgtgggctgg aacagcagat ttcagctaca     3600

tatatgaaca aatcctttat tattattata attatttttt tgcgtgaaag tgttacatat     3660

tctttcactt gtatgtacag agaggttttt ctgaatattt attttaaggg ttaaatcact     3720

tttgcttgtg tttattactg cttgaggttg agccttttga gtatttaaaa aatatatacc     3780

aacagaacta ctctcccaag gaaaatattg ccaccatttg tagaccacgt aaccttcaag     3840

tatgtgctac ttttttgtcc ctgtatctaa ctcaaatcag gaactgtatt ttttttaatg     3900

atttgctttt gaaacttgaa gtcttgaaaa cagtgtgatg caattactgc tgttctagcc     3960

cccaaagagt tttctgtgca aaatcttgag aatcaatcaa taaagaaaga tggaaggaag     4020

ggagaaattg gaatgtttta actgcagccc tcagaacttt agtaacagca caacaaatta     4080

aaaacaaaaa caactcatgc cacagtatgt cgtcttcatg tgtcttgcaa tgaactgttt     4140

cagtagccaa tcctctttct tagtatatga aaggacaggg atttttgttc ttgttgttct     4200

cgttgttgtt ttaagtttac tggggaaagt gcatttggcc aaatgaaatg gtagtcaagc     4260

ctattgcaac aaagttagga agtttgttgt ttgtttatta taaacaaaaa gcatgtgaaa     4320

gtgcacttaa gatagagttt ttattaatta cttacttatt acctagattt taaatagaca     4380

atccaaagtc tccccttcgt gttgccatca tcttgttgaa tcagccattt tatcgaggca     4440

cgtgatcagt gttgcaacat aatgaaaaag atggctactg tgccttgtgt tacttaatca     4500

tacagtaagc tgacctggaa atgaatgaaa ctattactcc taagaattac attgtatagc     4560

cccacagatt aaatttaatt aattaattca aaacatgtta aacgttactt tcatgtacta     4620

tggaaaagta caagtaggtt tacattactg atttccagaa gtaagtagtt tcccctttcc     4680

tagtcttctg tgtatgtgat gttgttaatt tcttttattg cattataaaa taaaaggatt     4740

atgtattttt aactaaggtg agacattgat atatcctttt gctacaagct atagctaatg     4800

tgctgagctt gtgccttggt gattgattga ttgattgact gattgtttta actgattact     4860

gtagatcaac ctgatgattt gtttgtttga aattggcagg aaaaatgcag ctttcaaatc     4920

attgggggga gaaaaaggat gtctttcagg attattttaa ttaatttttt tcataattga     4980

gacagaactg tttgttatgt accataatgc taaataaaac tgtggcactt ttcaccataa     5040

tttaatttag tggaaaaaga agacaatgct ttccatattg tgataaggta acatggggtt     5100

tttctgggcc agcctttaga acactgttag ggtacatacg ctaccttgat gaaagggacc     5160

ttcgtgcaac tgtagtcatc ttaaaggctt ctcatccact gtgcttctta atgtgtaatt     5220

aaagtgagga gaaattaaat actctgaggg cgttttatat aataaattcg tgaaga         5276


<210>  7
<211>  875
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(875)
<223>  UBE3A Isoform 2

<400>  7

Met Glu Lys Leu His Gln Cys Tyr Trp Lys Ser Gly Glu Pro Gln Ser 
1               5                   10                  15      


Asp Asp Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu 
            20                  25                  30          


Ile Glu Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala 
        35                  40                  45              


Cys Thr Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp 
    50                  55                  60                  


Asn Asn Ala Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala 
65                  70                  75                  80  


Lys Leu Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr 
                85                  90                  95      


Leu Glu Asn Ser Lys Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys 
            100                 105                 110         


Met Asn Lys Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu 
        115                 120                 125             


Thr Glu Glu Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu 
    130                 135                 140                 


Asp Tyr Ser Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala 
145                 150                 155                 160 


Glu Ala Leu Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu 
                165                 170                 175     


Glu Leu Lys Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu 
            180                 185                 190         


Lys Glu Lys Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu 
        195                 200                 205             


Ala Ser Ser Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu 
    210                 215                 220                 


Gln Lys Leu Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg 
225                 230                 235                 240 


Arg Val Tyr Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe 
                245                 250                 255     


Leu Asn Ala Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr 
            260                 265                 270         


Tyr His Asn Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile 
        275                 280                 285             


Ile Val Met Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met 
    290                 295                 300                 


Ala Leu Pro Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala 
305                 310                 315                 320 


Gln Gly Lys Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile 
                325                 330                 335     


Arg Arg Met Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile 
            340                 345                 350         


Ser Asn Glu Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile 
        355                 360                 365             


Val Ala Ala Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val 
    370                 375                 380                 


Gly Gly Glu Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro 
385                 390                 395                 400 


Ile Pro Glu Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu 
                405                 410                 415     


Arg Arg Asn Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu 
            420                 425                 430         


Gly Val Lys Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu 
        435                 440                 445             


Phe Ile Asn Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr 
    450                 455                 460                 


Thr Phe Phe Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys 
465                 470                 475                 480 


Pro Phe Ile Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp 
                485                 490                 495     


Asn Arg Ile Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser 
            500                 505                 510         


Leu Val Gln Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg 
        515                 520                 525             


Arg Asp His Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala 
    530                 535                 540                 


Met Glu Asn Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu 
545                 550                 555                 560 


Gly Glu Gln Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln 
                565                 570                 575     


Leu Val Val Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr 
            580                 585                 590         


Asp Glu Ser Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr 
        595                 600                 605             


Glu Gly Gln Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr 
    610                 615                 620                 


Asn Asn Cys Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys 
625                 630                 635                 640 


Leu Met Gly Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro 
                645                 650                 655     


Val Leu Tyr Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val 
            660                 665                 670         


Glu Asp Asp Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe 
        675                 680                 685             


Gly Asn Pro Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro 
    690                 695                 700                 


Ile Thr Asn Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr 
705                 710                 715                 720 


Ile Leu Asn Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly 
                725                 730                 735     


Phe His Met Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro 
            740                 745                 750         


Glu Glu Ile Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln 
        755                 760                 765             


Ala Leu Glu Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser 
    770                 775                 780                 


Val Leu Ile Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu 
785                 790                 795                 800 


Gln Lys Arg Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro 
                805                 810                 815     


Val Gly Gly Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro 
            820                 825                 830         


Asp Thr Glu Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu 
        835                 840                 845             


Leu Pro Glu Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys 
    850                 855                 860                 


Ala Ile Thr Tyr Ala Lys Gly Phe Gly Met Leu 
865                 870                 875 


<210>  8
<211>  2970
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2970)
<223>  UBE3v3 cDNA

<400>  8
tttttccgga taaggaagcg cgggtcccgc atgagccccg gcggtggcgg cagcgaaaga       60

gaacgaggcg gtggcgggcg gaggcggcgg gcgagggcga ctacgaccag tgaggcggcc      120

gccgcagccc aggcgcgggg gcgacgacag gttaaaaatc tgtaagagcc tgattttaga      180

attcaccagc tcctcagaag tttggcgaaa tatgagttat taagcctacg ctcagatcaa      240

ggtagcagct agactggtgt gacaacctgt ttttaatcag tgactcaaag ctgtgatcac      300

cctgatgtca ccgaatggcc acagcttgta aaagatcagg agaacctcag tctgacgaca      360

ttgaagctag ccgaatgaag cgagcagctg caaagcatct aatagaacgc tactaccacc      420

agttaactga gggctgtgga aatgaagcct gcacgaatga gttttgtgct tcctgtccaa      480

cttttcttcg tatggataat aatgcagcag ctattaaagc cctcgagctt tataagatta      540

atgcaaaact ctgtgatcct catccctcca agaaaggagc aagctcagct taccttgaga      600

actcgaaagg tgcccccaac aactcctgct ctgagataaa aatgaacaag aaaggcgcta      660

gaattgattt taaagatgtg acttacttaa cagaagagaa ggtatatgaa attcttgaat      720

tatgtagaga aagagaggat tattcccctt taatccgtgt tattggaaga gttttttcta      780

gtgctgaggc attggtacag agcttccgga aagttaaaca acacaccaag gaagaactga      840

aatctcttca agcaaaagat gaagacaaag atgaagatga aaaggaaaaa gctgcatgtt      900

ctgctgctgc tatggaagaa gactcagagg catcttcctc aaggataggt gatagctcac      960

agggagacaa caatttgcaa aaattaggcc ctgatgatgt gtctgtggat attgatgcca     1020

ttagaagggt ctacaccaga ttgctctcta atgaaaaaat tgaaactgcc tttctcaatg     1080

cacttgtata tttgtcacct aacgtggaat gtgacttgac gtatcacaat gtatactctc     1140

gagatcctaa ttatctgaat ttgttcatta tcgtaatgga gaatagaaat ctccacagtc     1200

ctgaatatct ggaaatggct ttgccattat tttgcaaagc gatgagcaag ctaccccttg     1260

cagcccaagg aaaactgatc agactgtggt ctaaatacaa tgcagaccag attcggagaa     1320

tgatggagac atttcagcaa cttattactt ataaagtcat aagcaatgaa tttaacagtc     1380

gaaatctagt gaatgatgat gatgccattg ttgctgcttc gaagtgcttg aaaatggttt     1440

actatgcaaa tgtagtggga ggggaagtgg acacaaatca caatgaagaa gatgatgaag     1500

agcccatccc tgagtccagc gagctgacac ttcaggaact tttgggagaa gaaagaagaa     1560

acaagaaagg tcctcgagtg gaccccctgg aaactgaact tggtgttaaa accctggatt     1620

gtcgaaaacc acttatccct tttgaagagt ttattaatga accactgaat gaggttctag     1680

aaatggataa agattatact tttttcaaag tagaaacaga gaacaaattc tcttttatga     1740

catgtccctt tatattgaat gctgtcacaa agaatttggg attatattat gacaatagaa     1800

ttcgcatgta cagtgaacga agaatcactg ttctctacag cttagttcaa ggacagcagt     1860

tgaatccata tttgagactc aaagttagac gtgaccatat catagatgat gcacttgtcc     1920

ggctagagat gatcgctatg gaaaatcctg cagacttgaa gaagcagttg tatgtggaat     1980

ttgaaggaga acaaggagtt gatgagggag gtgtttccaa agaatttttt cagctggttg     2040

tggaggaaat cttcaatcca gatattggta tgttcacata cgatgaatct acaaaattgt     2100

tttggtttaa tccatcttct tttgaaactg agggtcagtt tactctgatt ggcatagtac     2160

tgggtctggc tatttacaat aactgtatac tggatgtaca ttttcccatg gttgtctaca     2220

ggaagctaat ggggaaaaaa ggaacttttc gtgacttggg agactctcac ccagttctat     2280

atcagagttt aaaagattta ttggagtatg aagggaatgt ggaagatgac atgatgatca     2340

ctttccagat atcacagaca gatctttttg gtaacccaat gatgtatgat ctaaaggaaa     2400

atggtgataa aattccaatt acaaatgaaa acaggaagga atttgtcaat ctttattctg     2460

actacattct caataaatca gtagaaaaac agttcaaggc ttttcggaga ggttttcata     2520

tggtgaccaa tgaatctccc ttaaagtact tattcagacc agaagaaatt gaattgctta     2580

tatgtggaag ccggaatcta gatttccaag cactagaaga aactacagaa tatgacggtg     2640

gctataccag ggactctgtt ctgattaggg agttctggga aatcgttcat tcatttacag     2700

atgaacagaa aagactcttc ttgcagttta caacgggcac agacagagca cctgtgggag     2760

gactaggaaa attaaagatg attatagcca aaaatggccc agacacagaa aggttaccta     2820

catctcatac ttgctttaat gtgcttttac ttccggaata ctcaagcaaa gaaaaactta     2880

aagagagatt gttgaaggcc atcacgtatg ccaaaggatt tggcatgctg taaaacaaaa     2940

caaaacaaaa taaaacaaaa aaaaggaagg                                      2970


<210>  9
<211>  872
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(872)
<223>  UBE3A Isoform 3

<400>  9

Met Ala Thr Ala Cys Lys Arg Ser Gly Glu Pro Gln Ser Asp Asp Ile 
1               5                   10                  15      


Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg 
            20                  25                  30          


Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn 
        35                  40                  45              


Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala 
    50                  55                  60                  


Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys 
65                  70                  75                  80  


Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn 
                85                  90                  95      


Ser Lys Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys Met Asn Lys 
            100                 105                 110         


Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu 
        115                 120                 125             


Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser 
    130                 135                 140                 


Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu 
145                 150                 155                 160 


Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys 
                165                 170                 175     


Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys 
            180                 185                 190         


Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser 
        195                 200                 205             


Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu Gln Lys Leu 
    210                 215                 220                 


Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr 
225                 230                 235                 240 


Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala 
                245                 250                 255     


Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn 
            260                 265                 270         


Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met 
        275                 280                 285             


Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro 
    290                 295                 300                 


Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys 
305                 310                 315                 320 


Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met 
                325                 330                 335     


Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu 
            340                 345                 350         


Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala 
        355                 360                 365             


Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu 
    370                 375                 380                 


Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu 
385                 390                 395                 400 


Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn 
                405                 410                 415     


Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys 
            420                 425                 430         


Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn 
        435                 440                 445             


Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe 
    450                 455                 460                 


Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile 
465                 470                 475                 480 


Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile 
                485                 490                 495     


Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln 
            500                 505                 510         


Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His 
        515                 520                 525             


Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn 
    530                 535                 540                 


Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln 
545                 550                 555                 560 


Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val 
                565                 570                 575     


Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser 
            580                 585                 590         


Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln 
        595                 600                 605             


Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys 
    610                 615                 620                 


Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly 
625                 630                 635                 640 


Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr 
                645                 650                 655     


Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp 
            660                 665                 670         


Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro 
        675                 680                 685             


Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn 
    690                 695                 700                 


Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn 
705                 710                 715                 720 


Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met 
                725                 730                 735     


Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile 
            740                 745                 750         


Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu 
        755                 760                 765             


Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile 
    770                 775                 780                 


Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg 
785                 790                 795                 800 


Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly 
                805                 810                 815     


Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu 
            820                 825                 830         


Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu 
        835                 840                 845             


Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr 
    850                 855                 860                 


Tyr Ala Lys Gly Phe Gly Met Leu 
865                 870         


<210>  10
<211>  2767
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2767)
<223>  UBE3Av1 cDNA (bottom strand)

<400>  10
attttgtttt gttttgtttt acagcatgcc aaatcctttg gcatacgtga tggccttcaa       60

caatctctct ttaagttttt ctttgcttga gtattccgga agtaaaagca cattaaagca      120

agtatgagat gtaggtaacc tttctgtgtc tgggccattt ttggctataa tcatctttaa      180

ttttcctagt cctcccacag gtgctctgtc tgtgcccgtt gtaaactgca agaagagtct      240

tttctgttca tctgtaaatg aatgaacgat ttcccagaac tccctaatca gaacagagtc      300

cctggtatag ccaccgtcat attctgtagt ttcttctagt gcttggaaat ctagattccg      360

gcttccacat ataagcaatt caatttcttc tggtctgaat aagtacttta agggagattc      420

attggtcacc atatgaaaac ctctccgaaa agccttgaac tgtttttcta ctgatttatt      480

gagaatgtag tcagaataaa gattgacaaa ttccttcctg ttttcatttg taattggaat      540

tttatcacca ttttccttta gatcatacat cattgggtta ccaaaaagat ctgtctgtga      600

tatctggaaa gtgatcatca tgtcatcttc cacattccct tcatactcca ataaatcttt      660

taaactctga tatagaactg ggtgagagtc tcccaagtca cgaaaagttc cttttttccc      720

cattagcttc ctgtagacaa ccatgggaaa atgtacatcc agtatacagt tattgtaaat      780

agccagaccc agtactatgc caatcagagt aaactgaccc tcagtttcaa aagaagatgg      840

attaaaccaa aacaattttg tagattcatc gtatgtgaac ataccaatat ctggattgaa      900

gatttcctcc acaaccagct gaaaaaattc tttggaaaca cctccctcat caactccttg      960

ttctccttca aattccacat acaactgctt cttcaagtct gcaggatttt ccatagcgat     1020

catctctagc cggacaagtg catcatctat gatatggtca cgtctaactt tgagtctcaa     1080

atatggattc aactgctgtc cttgaactaa gctgtagaga acagtgattc ttcgttcact     1140

gtacatgcga attctattgt cataatataa tcccaaattc tttgtgacag cattcaatat     1200

aaagggacat gtcataaaag agaatttgtt ctctgtttct actttgaaaa aagtataatc     1260

tttatccatt tctagaacct cattcagtgg ttcattaata aactcttcaa aagggataag     1320

tggttttcga caatccaggg ttttaacacc aagttcagtt tccagggggt ccactcgagg     1380

acctttcttg tttcttcttt cttctcccaa aagttcctga agtgtcagct cgctggactc     1440

agggatgggc tcttcatcat cttcttcatt gtgatttgtg tccacttccc ctcccactac     1500

atttgcatag taaaccattt tcaagcactt cgaagcagca acaatggcat catcatcatt     1560

cactagattt cgactgttaa attcattgct tatgacttta taagtaataa gttgctgaaa     1620

tgtctccatc attctccgaa tctggtctgc attgtattta gaccacagtc tgatcagttt     1680

tccttgggct gcaaggggta gcttgctcat cgctttgcaa aataatggca aagccatttc     1740

cagatattca ggactgtgga gatttctatt ctccattacg ataatgaaca aattcagata     1800

attaggatct cgagagtata cattgtgata cgtcaagtca cattccacgt taggtgacaa     1860

atatacaagt gcattgagaa aggcagtttc aattttttca ttagagagca atctggtgta     1920

gacccttcta atggcatcaa tatccacaga cacatcatca gggcctaatt tttgcaaatt     1980

gttgtctccc tgtgagctat cacctatcct tgaggaagat gcttctgagt cttcttccat     2040

agcagcagca gaacatgcag ctttttcctt ttcatcctca tctttgtctt catcttttgc     2100

ttgaagagat ttcagttctt ccttggtgtg ttgtttaact ttccggaagc tctgtaccaa     2160

tgcctcagca ctagaaaaaa ctcttccaat aacacggatt aaaggggaat aatcctctct     2220

ttctctacat aattcaagaa tttcatatac cttctcttct gttaagtaag tcacatcttt     2280

aaaatcaatt ctagcgcctt tcttgttcat ttttatctca gagcaggagt tgttgggggc     2340

acctttcgag ttctcaaggt aagctgagct tgctcctttc ttggagggat gaggatcaca     2400

gagttttgca ttaatcttat aaagctcgag ggctttaata gctgctgcat tattatccat     2460

acgaagaaaa gttggacagg aagcacaaaa ctcattcgtg caggcttcat ttccacagcc     2520

ctcagttaac tggtggtagt agcgttctat tagatgcttt gcagctgctc gcttcattcg     2580

gctagcttca atgtcgtcag actgaggttc tcctgatctg gtctccacca gccttgtggg     2640

taagtacccc aagattgctt ccaaacttgt atctcccaga cagaagagct aaaaattgat     2700

gataacccca tgtaccagct gactcatttg tgaaagtgcg accctccagc atcagatgtc     2760

atactgt                                                               2767


<210>  11
<211>  5276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UBE3Av2 cDNA (bottom strand)


<220>
<221>  misc_feature
<222>  (1)..(5276)
<223>  UBE3A v2 cDNA (bottom strand)

<400>  11
tcttcacgaa tttattatat aaaacgccct cagagtattt aatttctcct cactttaatt       60

acacattaag aagcacagtg gatgagaagc ctttaagatg actacagttg cacgaaggtc      120

cctttcatca aggtagcgta tgtaccctaa cagtgttcta aaggctggcc cagaaaaacc      180

ccatgttacc ttatcacaat atggaaagca ttgtcttctt tttccactaa attaaattat      240

ggtgaaaagt gccacagttt tatttagcat tatggtacat aacaaacagt tctgtctcaa      300

ttatgaaaaa aattaattaa aataatcctg aaagacatcc tttttctccc cccaatgatt      360

tgaaagctgc atttttcctg ccaatttcaa acaaacaaat catcaggttg atctacagta      420

atcagttaaa acaatcagtc aatcaatcaa tcaatcacca aggcacaagc tcagcacatt      480

agctatagct tgtagcaaaa ggatatatca atgtctcacc ttagttaaaa atacataatc      540

cttttatttt ataatgcaat aaaagaaatt aacaacatca catacacaga agactaggaa      600

aggggaaact acttacttct ggaaatcagt aatgtaaacc tacttgtact tttccatagt      660

acatgaaagt aacgtttaac atgttttgaa ttaattaatt aaatttaatc tgtggggcta      720

tacaatgtaa ttcttaggag taatagtttc attcatttcc aggtcagctt actgtatgat      780

taagtaacac aaggcacagt agccatcttt ttcattatgt tgcaacactg atcacgtgcc      840

tcgataaaat ggctgattca acaagatgat ggcaacacga aggggagact ttggattgtc      900

tatttaaaat ctaggtaata agtaagtaat taataaaaac tctatcttaa gtgcactttc      960

acatgctttt tgtttataat aaacaaacaa caaacttcct aactttgttg caataggctt     1020

gactaccatt tcatttggcc aaatgcactt tccccagtaa acttaaaaca acaacgagaa     1080

caacaagaac aaaaatccct gtcctttcat atactaagaa agaggattgg ctactgaaac     1140

agttcattgc aagacacatg aagacgacat actgtggcat gagttgtttt tgtttttaat     1200

ttgttgtgct gttactaaag ttctgagggc tgcagttaaa acattccaat ttctcccttc     1260

cttccatctt tctttattga ttgattctca agattttgca cagaaaactc tttgggggct     1320

agaacagcag taattgcatc acactgtttt caagacttca agtttcaaaa gcaaatcatt     1380

aaaaaaaata cagttcctga tttgagttag atacagggac aaaaaagtag cacatacttg     1440

aaggttacgt ggtctacaaa tggtggcaat attttccttg ggagagtagt tctgttggta     1500

tatatttttt aaatactcaa aaggctcaac ctcaagcagt aataaacaca agcaaaagtg     1560

atttaaccct taaaataaat attcagaaaa acctctctgt acatacaagt gaaagaatat     1620

gtaacacttt cacgcaaaaa aataattata ataataataa aggatttgtt catatatgta     1680

gctgaaatct gctgttccag cccacatgtc cccaataaag aagggaggca cagacatagg     1740

tgactactgt ggttgactat cttacagcct ttttgtactg ggacactatc accaccaaaa     1800

atttatccct cgttatattt ttaaaatttt ttaaattttt tctttttttt tccttccttt     1860

tttttgtttt attttgtttt gttttgtttt acagcatgcc aaatcctttg gcatacgtga     1920

tggccttcaa caatctctct ttaagttttt ctttgcttga gtattccgga agtaaaagca     1980

cattaaagca agtatgagat gtaggtaacc tttctgtgtc tgggccattt ttggctataa     2040

tcatctttaa ttttcctagt cctcccacag gtgctctgtc tgtgcccgtt gtaaactgca     2100

agaagagtct tttctgttca tctgtaaatg aatgaacgat ttcccagaac tccctaatca     2160

gaacagagtc cctggtatag ccaccgtcat attctgtagt ttcttctagt gcttggaaat     2220

ctagattccg gcttccacat ataagcaatt caatttcttc tggtctgaat aagtacttta     2280

agggagattc attggtcacc atatgaaaac ctctccgaaa agccttgaac tgtttttcta     2340

ctgatttatt gagaatgtag tcagaataaa gattgacaaa ttccttcctg ttttcatttg     2400

taattggaat tttatcacca ttttccttta gatcatacat cattgggtta ccaaaaagat     2460

ctgtctgtga tatctggaaa gtgatcatca tgtcatcttc cacattccct tcatactcca     2520

ataaatcttt taaactctga tatagaactg ggtgagagtc tcccaagtca cgaaaagttc     2580

cttttttccc cattagcttc ctgtagacaa ccatgggaaa atgtacatcc agtatacagt     2640

tattgtaaat agccagaccc agtactatgc caatcagagt aaactgaccc tcagtttcaa     2700

aagaagatgg attaaaccaa aacaattttg tagattcatc gtatgtgaac ataccaatat     2760

ctggattgaa gatttcctcc acaaccagct gaaaaaattc tttggaaaca cctccctcat     2820

caactccttg ttctccttca aattccacat acaactgctt cttcaagtct gcaggatttt     2880

ccatagcgat catctctagc cggacaagtg catcatctat gatatggtca cgtctaactt     2940

tgagtctcaa atatggattc aactgctgtc cttgaactaa gctgtagaga acagtgattc     3000

ttcgttcact gtacatgcga attctattgt cataatataa tcccaaattc tttgtgacag     3060

cattcaatat aaagggacat gtcataaaag agaatttgtt ctctgtttct actttgaaaa     3120

aagtataatc tttatccatt tctagaacct cattcagtgg ttcattaata aactcttcaa     3180

aagggataag tggttttcga caatccaggg ttttaacacc aagttcagtt tccagggggt     3240

ccactcgagg acctttcttg tttcttcttt cttctcccaa aagttcctga agtgtcagct     3300

cgctggactc agggatgggc tcttcatcat cttcttcatt gtgatttgtg tccacttccc     3360

ctcccactac atttgcatag taaaccattt tcaagcactt cgaagcagca acaatggcat     3420

catcatcatt cactagattt cgactgttaa attcattgct tatgacttta taagtaataa     3480

gttgctgaaa tgtctccatc attctccgaa tctggtctgc attgtattta gaccacagtc     3540

tgatcagttt tccttgggct gcaaggggta gcttgctcat cgctttgcaa aataatggca     3600

aagccatttc cagatattca ggactgtgga gatttctatt ctccattacg ataatgaaca     3660

aattcagata attaggatct cgagagtata cattgtgata cgtcaagtca cattccacgt     3720

taggtgacaa atatacaagt gcattgagaa aggcagtttc aattttttca ttagagagca     3780

atctggtgta gacccttcta atggcatcaa tatccacaga cacatcatca gggcctaatt     3840

tttgcaaatt gttgtctccc tgtgagctat cacctatcct tgaggaagat gcttctgagt     3900

cttcttccat agcagcagca gaacatgcag ctttttcctt ttcatcttca tctttgtctt     3960

catcttttgc ttgaagagat ttcagttctt ccttggtgtg ttgtttaact ttccggaagc     4020

tctgtaccaa tgcctcagca ctagaaaaaa ctcttccaat aacacggatt aaaggggaat     4080

aatcctctct ttctctacat aattcaagaa tttcatatac cttctcttct gttaagtaag     4140

tcacatcttt aaaatcaatt ctagcgcctt tcttgttcat ttttatctca gagcaggagt     4200

tgttgggggc acctttcgag ttctcaaggt aagctgagct tgctcctttc ttggagggat     4260

gaggatcaca gagttttgca ttaatcttat aaagctcgag ggctttaata gctgctgcat     4320

tattatccat acgaagaaaa gttggacagg aagcacaaaa ctcattcgtg caggcttcat     4380

ttccacagcc ctcagttaac tggtggtagt agcgttctat tagatgcttt gcagctgctc     4440

gcttcattcg gctagcttca atgtcgtcag actgaggttc tcctgatttc caataacact     4500

ggtgcagctt ctccatcctg caagccactc cttttacctc cactgtaact ctcttttaca     4560

agctgtggcc attcggtgac atcagggtga tcacagcttt gagtcactga ttaaaaacag     4620

gttgtcacac cagtctagct gctaccttga tctgagcgta ggcttaataa ctcatatttc     4680

gccaaacttc tgaggagctg gtgaattcta aaatcaggct cttacagatt tttaacctgt     4740

cgtcgccccc gcgcctgggc tgcggcggcc gcctcactgg tcgtagtcgc cctcgcccgc     4800

cgcctccgcc cgccaccgcc tcgttctctt tcgctgccgc caccgccggg gctcatgcgg     4860

gacccgcgct tccttatccg gaaaacgagg ccgggaaagg gagcgccggg gccgccgaaa     4920

tcccggcgtt cgtcgccagc cgccgctgcc tgtccacacc ggggggctga ggggccctcc     4980

tgccaggggc tacaggccgc gagctattcc gaggaggagc cgaaggaggc gccgccgccc     5040

gcagccgagc gcgccgggtc ggcagaggtg aagcgtaagt aggcggcgga tggcgggcgc     5100

ccgcgctggc ggatggctac gcggcggagg ggtgcgcgag cgagcgaagc ctggtgtgtc     5160

gggtcctggc gaagggaaaa ggccccgtcg tctcctgtag tcaccccgag cccagcgcca     5220

ccatcttggg agacacacgg atctcgcggc cgcggcgcaa gacgggagga ctggct         5276


<210>  12
<211>  2970
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UBE3Av3 (bottom strand)


<220>
<221>  misc_feature
<222>  (1)..(2970)
<223>  UBE3Av3 cDNA (bottom strand)

<400>  12
ccttcctttt ttttgtttta ttttgttttg ttttgtttta cagcatgcca aatcctttgg       60

catacgtgat ggccttcaac aatctctctt taagtttttc tttgcttgag tattccggaa      120

gtaaaagcac attaaagcaa gtatgagatg taggtaacct ttctgtgtct gggccatttt      180

tggctataat catctttaat tttcctagtc ctcccacagg tgctctgtct gtgcccgttg      240

taaactgcaa gaagagtctt ttctgttcat ctgtaaatga atgaacgatt tcccagaact      300

ccctaatcag aacagagtcc ctggtatagc caccgtcata ttctgtagtt tcttctagtg      360

cttggaaatc tagattccgg cttccacata taagcaattc aatttcttct ggtctgaata      420

agtactttaa gggagattca ttggtcacca tatgaaaacc tctccgaaaa gccttgaact      480

gtttttctac tgatttattg agaatgtagt cagaataaag attgacaaat tccttcctgt      540

tttcatttgt aattggaatt ttatcaccat tttcctttag atcatacatc attgggttac      600

caaaaagatc tgtctgtgat atctggaaag tgatcatcat gtcatcttcc acattccctt      660

catactccaa taaatctttt aaactctgat atagaactgg gtgagagtct cccaagtcac      720

gaaaagttcc ttttttcccc attagcttcc tgtagacaac catgggaaaa tgtacatcca      780

gtatacagtt attgtaaata gccagaccca gtactatgcc aatcagagta aactgaccct      840

cagtttcaaa agaagatgga ttaaaccaaa acaattttgt agattcatcg tatgtgaaca      900

taccaatatc tggattgaag atttcctcca caaccagctg aaaaaattct ttggaaacac      960

ctccctcatc aactccttgt tctccttcaa attccacata caactgcttc ttcaagtctg     1020

caggattttc catagcgatc atctctagcc ggacaagtgc atcatctatg atatggtcac     1080

gtctaacttt gagtctcaaa tatggattca actgctgtcc ttgaactaag ctgtagagaa     1140

cagtgattct tcgttcactg tacatgcgaa ttctattgtc ataatataat cccaaattct     1200

ttgtgacagc attcaatata aagggacatg tcataaaaga gaatttgttc tctgtttcta     1260

ctttgaaaaa agtataatct ttatccattt ctagaacctc attcagtggt tcattaataa     1320

actcttcaaa agggataagt ggttttcgac aatccagggt tttaacacca agttcagttt     1380

ccagggggtc cactcgagga cctttcttgt ttcttctttc ttctcccaaa agttcctgaa     1440

gtgtcagctc gctggactca gggatgggct cttcatcatc ttcttcattg tgatttgtgt     1500

ccacttcccc tcccactaca tttgcatagt aaaccatttt caagcacttc gaagcagcaa     1560

caatggcatc atcatcattc actagatttc gactgttaaa ttcattgctt atgactttat     1620

aagtaataag ttgctgaaat gtctccatca ttctccgaat ctggtctgca ttgtatttag     1680

accacagtct gatcagtttt ccttgggctg caaggggtag cttgctcatc gctttgcaaa     1740

ataatggcaa agccatttcc agatattcag gactgtggag atttctattc tccattacga     1800

taatgaacaa attcagataa ttaggatctc gagagtatac attgtgatac gtcaagtcac     1860

attccacgtt aggtgacaaa tatacaagtg cattgagaaa ggcagtttca attttttcat     1920

tagagagcaa tctggtgtag acccttctaa tggcatcaat atccacagac acatcatcag     1980

ggcctaattt ttgcaaattg ttgtctccct gtgagctatc acctatcctt gaggaagatg     2040

cctctgagtc ttcttccata gcagcagcag aacatgcagc tttttccttt tcatcttcat     2100

ctttgtcttc atcttttgct tgaagagatt tcagttcttc cttggtgtgt tgtttaactt     2160

tccggaagct ctgtaccaat gcctcagcac tagaaaaaac tcttccaata acacggatta     2220

aaggggaata atcctctctt tctctacata attcaagaat ttcatatacc ttctcttctg     2280

ttaagtaagt cacatcttta aaatcaattc tagcgccttt cttgttcatt tttatctcag     2340

agcaggagtt gttgggggca cctttcgagt tctcaaggta agctgagctt gctcctttct     2400

tggagggatg aggatcacag agttttgcat taatcttata aagctcgagg gctttaatag     2460

ctgctgcatt attatccata cgaagaaaag ttggacagga agcacaaaac tcattcgtgc     2520

aggcttcatt tccacagccc tcagttaact ggtggtagta gcgttctatt agatgctttg     2580

cagctgctcg cttcattcgg ctagcttcaa tgtcgtcaga ctgaggttct cctgatcttt     2640

tacaagctgt ggccattcgg tgacatcagg gtgatcacag ctttgagtca ctgattaaaa     2700

acaggttgtc acaccagtct agctgctacc ttgatctgag cgtaggctta ataactcata     2760

tttcgccaaa cttctgagga gctggtgaat tctaaaatca ggctcttaca gatttttaac     2820

ctgtcgtcgc ccccgcgcct gggctgcggc ggccgcctca ctggtcgtag tcgccctcgc     2880

ccgccgcctc cgcccgccac cgcctcgttc tctttcgctg ccgccaccgc cggggctcat     2940

gcgggacccg cgcttcctta tccggaaaaa                                      2970


<210>  13
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence

<400>  13

Ser Gly Glu Pro Gln Ser Asp Asp Ile Glu Ala Ser Arg Met Lys Arg 
1               5                   10                  15      


Ala Ala Ala Lys His Leu Ile Glu Arg Tyr Tyr His Gln Leu Thr Glu 
            20                  25                  30          


Gly Cys Gly Asn Glu Ala Cys Thr Asn Glu Phe Cys Ala Ser Cys Pro 
        35                  40                  45              


Thr Phe Leu Arg Met Asp Asn Asn Ala Ala Ala Ile Lys Ala Leu Glu 
    50                  55                  60                  


Leu Tyr Lys Ile Asn Ala Lys Leu Cys Asp Pro His Pro Ser Lys Lys 
65                  70                  75                  80  


Gly Ala Ser Ser Ala Tyr Leu Glu Asn Ser Lys Gly Ala Pro Asn Asn 
                85                  90                  95      


Ser Cys Ser Glu Ile Lys Met Asn Lys Lys Gly Ala Arg Ile Asp Phe 
            100                 105                 110         


Lys Asp Val Thr Tyr Leu Thr Glu Glu Lys Val Tyr Glu Ile Leu Glu 
        115                 120                 125             


Leu Cys Arg Glu Arg Glu Asp Tyr Ser Pro Leu Ile Arg Val Ile Gly 
    130                 135                 140                 


Arg Val Phe Ser Ser Ala Glu Ala Leu Val Gln Ser Phe Arg Lys Val 
145                 150                 155                 160 


Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu Gln Ala Lys Asp Glu 
                165                 170                 175     


Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala Cys Ser Ala Ala Ala 
            180                 185                 190         


Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg Ile Gly Asp Ser Ser 
        195                 200                 205             


Gln Gly Asp Asn Asn Leu Gln Lys Leu Gly Pro Asp Asp Val Ser Val 
    210                 215                 220                 


Asp Ile Asp Ala Ile Arg Arg Val Tyr Thr Arg Leu Leu Ser Asn Glu 
225                 230                 235                 240 


Lys Ile Glu Thr Ala Phe Leu Asn Ala Leu Val Tyr Leu Ser Pro Asn 
                245                 250                 255     


Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr Ser Arg Asp Pro Asn 
            260                 265                 270         


Tyr Leu Asn Leu Phe Ile Ile Val Met Glu Asn Arg Asn Leu His Ser 
        275                 280                 285             


Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe Cys Lys Ala Met Ser 
    290                 295                 300                 


Lys Leu Pro Leu Ala Ala Gln Gly Lys Leu Ile Arg Leu Trp Ser Lys 
305                 310                 315                 320 


Tyr Asn Ala Asp Gln Ile Arg Arg Met Met Glu Thr Phe Gln Gln Leu 
                325                 330                 335     


Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn Ser Arg Asn Leu Val 
            340                 345                 350         


Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys Cys Leu Lys Met Val 
        355                 360                 365             


Tyr Tyr Ala Asn Val Val Gly Gly Glu Val Asp Thr Asn His Asn Glu 
    370                 375                 380                 


Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser Glu Leu Thr Leu Gln 
385                 390                 395                 400 


Glu Leu Leu Gly Glu Glu Arg Arg Asn Lys Lys Gly Pro Arg Val Asp 
                405                 410                 415     


Pro Leu Glu Thr Glu Leu Gly Val Lys Thr Leu Asp Cys Arg Lys Pro 
            420                 425                 430         


Leu Ile Pro Phe Glu Glu Phe Ile Asn Glu Pro Leu Asn Glu Val Leu 
        435                 440                 445             


Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val Glu Thr Glu Asn Lys 
    450                 455                 460                 


Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn Ala Val Thr Lys Asn 
465                 470                 475                 480 


Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met Tyr Ser Glu Arg Arg 
                485                 490                 495     


Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln Gln Leu Asn Pro Tyr 
            500                 505                 510         


Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile Asp Asp Ala Leu Val 
        515                 520                 525             


Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala Asp Leu Lys Lys Gln 
    530                 535                 540                 


Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val Asp Glu Gly Gly Val 
545                 550                 555                 560 


Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu Ile Phe Asn Pro Asp 
                565                 570                 575     


Ile Gly Met Phe Thr Tyr Asp Glu Ser Thr Lys Leu Phe Trp Phe Asn 
            580                 585                 590         


Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr Leu Ile Gly Ile Val 
        595                 600                 605             


Leu Gly Leu Ala Ile Tyr Asn Asn Cys Ile Leu Asp Val His Phe Pro 
    610                 615                 620                 


Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys Gly Thr Phe Arg Asp 
625                 630                 635                 640 


Leu Gly Asp Ser His Pro Val Leu Tyr Gln Ser Leu Lys Asp Leu Leu 
                645                 650                 655     


Glu Tyr Glu Gly Asn Val Glu Asp Asp Met Met Ile Thr Phe Gln Ile 
            660                 665                 670         


Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met Tyr Asp Leu Lys Glu 
        675                 680                 685             


Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn Arg Lys Glu Phe Val 
    690                 695                 700                 


Asn Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser Val Glu Lys Gln Phe 
705                 710                 715                 720 


Lys Ala Phe Arg Arg Gly Phe His Met Val Thr Asn Glu Ser Pro Leu 
                725                 730                 735     


Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu Leu Ile Cys Gly Ser 
            740                 745                 750         


Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr Thr Glu Tyr Asp Gly 
        755                 760                 765             


Gly Tyr Thr Arg Asp Ser Val Leu Ile Arg Glu Phe Trp Glu Ile Val 
    770                 775                 780                 


His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe Leu Gln Phe Thr Thr 
785                 790                 795                 800 


Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly Lys Leu Lys Met Ile 
                805                 810                 815     


Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu Pro Thr Ser His Thr 
            820                 825                 830         


Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser Ser Lys Glu Lys Leu 
        835                 840                 845             


Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala Lys Gly Phe Gly Met 
    850                 855                 860                 


Leu 
865 


<210>  14
<211>  145
<212>  DNA
<213>  adeno-associated virus 1


<220>
<221>  misc_feature
<222>  (1)..(145)
<223>  AAV1 ITR

<400>  14
ttgcccactc cctctctgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcag agagggagtg      120

ggcaactcca tcactagggg taatc                                            145


<210>  15
<211>  145
<212>  DNA
<213>  adeno-associated virus 2


<220>
<221>  misc_feature
<222>  (1)..(145)
<223>  AAV2 ITR

<400>  15
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  16
<211>  143
<212>  DNA
<213>  adeno-associated virus 3


<220>
<221>  misc_feature
<222>  (1)..(143)
<223>  AAV3 ITR

<400>  16
ttggccactc cctctatgcg cactcgctcg ctcggtgggg cctggcgacc aaaggtcgcc       60

agacggacgt gctttgcacg tccggcccca ccgagcgagc gagtgcgcat agagggagtg      120

gccaactcca tcactagagg tat                                              143


<210>  17
<211>  146
<212>  DNA
<213>  adeno-associated virus 4


<220>
<221>  misc_feature
<222>  (1)..(146)
<223>  AAV4 ITR

<400>  17
atgccggggt tctacgagat cgtgctgaag gtgcccagcg acctggacga gcacctgccc       60

ggcatttctg actcttttgt gagctgggtg gccgagaagg aatgggagct gccgccggat      120

tctgacatgg acttgaatct gattga                                           146


<210>  18
<211>  143
<212>  DNA
<213>  adeno-associated virus 5


<220>
<221>  misc_feature
<222>  (1)..(143)
<223>  AAV5 ITR

<400>  18
ctctcccccc tgtcgcgttc gctcgctcgc tggctcgttt gggggggtgg cagctcaaag       60

agctgccaga cgacggccct ctggccgtcg cccccccaaa cgagccagcg agcgagcgaa      120

cgcgacaggg gggagagtgc cac                                              143


<210>  19
<211>  145
<212>  DNA
<213>  adeno-associated virus 6


<220>
<221>  misc_feature
<222>  (1)..(145)
<223>  AAV6 ITR

<400>  19
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  20
<211>  145
<212>  DNA
<213>  adeno-associated virus 7


<220>
<221>  misc_feature
<222>  (1)..(145)
<223>  AAV7 ITR

<400>  20
ttggccactc cctctatgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcat agagggagtg      120

gccaactcca tcactagggg taccg                                            145


<210>  21
<211>  146
<212>  DNA
<213>  adeno-associated virus 8


<220>
<221>  misc_feature
<222>  (1)..(146)
<223>  AAV8 ITR

<400>  21
cagagaggga gtggccaact ccatcactag gggtagcgcg aagcgcctcc cacgctgccg       60

cgtcagcgct gacgtaaatt acgtcatagg ggagtggtcc tgtattagct gtcacgtgag      120

tgcttttgcg gcattttgcg acacca                                           146


<210>  22
<211>  61
<212>  DNA
<213>  adeno-associated virus 2


<220>
<221>  misc_feature
<222>  (1)..(61)
<223>  truncated AAV2 ITR

<400>  22
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

g                                                                       61


<210>  23
<211>  6619
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid sequence


<220>
<221>  misc_feature
<222>  (1)..(6619)
<223>  pTR-UphUBE3 ITR-ITR sequence (bottom strand)

<400>  23
cccccccccc cccccccctg cagcccagct gcattaatga atcggccaac gcgcggggag       60

aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt      120

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga      180

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg      240

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa      300

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt      360

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct      420

gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct gtaggtatct      480

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc      540

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt      600

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc      660

tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat      720

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa      780

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa      840

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga      900

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct      960

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     1020

cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc     1080

catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg     1140

ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat     1200

aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat     1260

ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg     1320

caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc     1380

attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa     1440

agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc     1500

actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt     1560

ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag     1620

ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt     1680

gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag     1740

atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac     1800

cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc     1860

gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca     1920

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg     1980

ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat     2040

gacattaacc tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga     2100

tgacggtgaa aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc     2160

ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg     2220

ctggcttaac tatgcggcat cagagcagat tgtactgaga gtgcaccata tgcggtgtga     2280

aataccgcac agatgcgtaa ggagaaaata ccgcatcagg aaattgtaaa cgttaatatt     2340

ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat tttttaacca ataggccgaa     2400

atcggcaaaa tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca     2460

gtttggaaca agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc     2520

gtctatcagg gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg     2580

aggtgccgta aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg     2640

ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg     2700

gcgctggcaa gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg     2760

ccgctacagg gcgcgtcgcg ccattcgcca ttcaggctac gcaactgttg ggaagggcga     2820

tcggtgcggg cctcttcgct attacgccag ctggcctgca gggggggggg ggggggggtt     2880

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     2940

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggagtggc     3000

caactccatc actaggggtt cctagatctc tccccagcat gcctgctatt gtcttcccaa     3060

tcctccccct tgctgtcctg ccccacccca ccccccagaa tagaatgaca cctactcaga     3120

caatgcgatg caatttcctc attttattag gaaaggacag tgggagtggc accttccagg     3180

gtcaaggaag gcacggggga ggggcaaaca acagatggct ggcaactaga aggcacagtc     3240

gaggctgatc agcgagctct agtcgacatc gatatgcatc ccggggctag cttacagcat     3300

gccaaatcct ttggcatacg tgatggcctt caacaatctc tctttaagtt tttctttgct     3360

tgagtattcc ggaagtaaaa gcacattaaa gcaagtatga gatgtaggta acctttctgt     3420

gtctgggcca tttttggcta taatcatctt taattttcct agtcctccca caggtgctct     3480

gtctgtgccc gttgtaaact gcaagaagag tcttttctgt tcatctgtaa atgaatgaac     3540

gatttcccag aactccctaa tcagaacaga gtccctggta tagccaccgt catattctgt     3600

agtttcttct agtgcttgga aatctagatt ccggcttcca catataagca attcaatttc     3660

ttctggtctg aataagtact ttaagggaga ttcattggtc accatatgaa aacctctccg     3720

aaaagccttg aactgttttt ctactgattt attgagaatg tagtcagaat aaagattgac     3780

aaattccttc ctgttttcat ttgtaattgg aattttatca ccattttcct ttagatcata     3840

catcattggg ttaccaaaaa gatctgtctg tgatatctgg aaagtgatca tcatgtcatc     3900

ttccacattc ccttcatact ccaataaatc ttttaaactc tgatatagaa ctgggtgaga     3960

gtctcccaag tcacgaaaag ttcctttttt ccccattagc ttcctgtaga caaccatggg     4020

aaaatgtaca tccagtatac agttattgta aatagccaga cccagtacta tgccaatcag     4080

agtaaactga ccctcagttt caaaagaaga tggattaaac caaaacaatt ttgtagattc     4140

atcgtatgtg aacataccaa tatctggatt gaagatttcc tccacaacca gctgaaaaaa     4200

ttctttggaa acacctccct catcaactcc ttgttctcct tcaaattcca catacaactg     4260

cttcttcaag tctgcaggat tttccatagc gatcatctct agccggacaa gtgcatcatc     4320

tatgatatgg tcacgtctaa ctttgagtct caaatatgga ttcaactgct gtccttgaac     4380

taagctgtag agaacagtga ttcttcgttc actgtacatg cgaattctat tgtcataata     4440

taatcccaaa ttctttgtga cagcattcaa tataaaggga catgtcataa aagagaattt     4500

gttctctgtt tctactttga aaaaagtata atctttatcc atttctagaa cctcattcag     4560

tggttcatta ataaactctt caaaagggat aagtggtttt cgacaatcca gggttttaac     4620

accaagttca gtttccaggg ggtccactcg aggacctttc ttgtttcttc tttcttctcc     4680

caaaagttcc tgaagtgtca gctcgctgga ctcagggatg ggctcttcat catcttcttc     4740

attgtgattt gtgtccactt cccctcccac tacatttgca tagtaaacca ttttcaagca     4800

cttcgaagca gcaacaatgg catcatcatc attcactaga tttcgactgt taaattcatt     4860

gcttatgact ttataagtaa taagttgctg aaatgtctcc atcattctcc gaatctggtc     4920

tgcattgtat ttagaccaca gtctgatcag ttttccttgg gctgcaaggg gtagcttgct     4980

catcgctttg caaaataatg gcaaagccat ttccagatat tcaggactgt ggagatttct     5040

attctccatt acgataatga acaaattcag ataattagga tctcgagagt atacattgtg     5100

atacgtcaag tcacattcca cgttaggtga caaatataca agtgcattga gaaaggcagt     5160

ttcaattttt tcattagaga gcaatctggt gtagaccctt ctaatggcat caatatccac     5220

agacacatca tcagggccta atttttgcaa attgttgtct ccctgtgagc tatcacctat     5280

ccttgaggaa gatgcttctg agtcttcttc catagcagca gcagaacatg cagctttttc     5340

cttttcatct tcatctttgt cttcatcttt tgcttgaaga gatttcagtt cttccttggt     5400

gtgttgttta actttccgga agctctgtac caatgcctca gcactagaaa aaactcttcc     5460

aataacacgg attaaagggg aataatcctc tctttctcta cataattcaa gaatttcata     5520

taccttctct tctgttaagt aagtcacatc tttaaaatca attctagcgc ctttcttgtt     5580

catttttatc tcagagcagg agttgttggg ggcacctttc gagttctcaa ggtaagctga     5640

gcttgctcct ttcttggagg gatgaggatc acagagtttt gcattaatct tataaagctc     5700

gagggcttta atagctgctg cattattatc catacgaaga aaagttggac aggaagcaca     5760

aaactcattc gtgcaggctt catttccaca gccctcagtt aactggtggt agtagcgttc     5820

tattagatgc tttgcagctg ctcgcttcat ggtggaccgg taagcttcgt ctaacaaaaa     5880

agccaaaaac ggccagaatt tagcggacaa tttactagtc taacactgaa aattacatat     5940

tgacccaaat gattacattt caaaaggtgc ctaaaaaact tcacaaaaca cactcgccaa     6000

ccccgagcgc acgtacccag cccagcagcc cgctactcac caagtgacga tcacagcgat     6060

ccacaaacaa gaaccgcgac ccaaatcccg gctgcgacgg aactagctgt gccacacccg     6120

gcgcgtcctt atataatcat cggcgttcac cgccccacgg agatccctcc gcagaatcgc     6180

cgagaaggga ctacttttcc tcgcctgttc cgctctctgg aaagaaaacc agtgccctag     6240

agtcacccaa gtcccgtcct aaaatgtcct tctgctgata ctggggttct aaggccgagt     6300

cttatgagca gcgggccgct gtcctgagcg tccgggcgga aggatcagga cgctcgctgc     6360

gcccttcgtc tgacgtggca gcgctcgccg tgaggagggg ggcgcccgcg ggaggcgcca     6420

aaacccggcg cggaggccgg ccggccttaa ttaagcgatc gcgaattcag atctaggaac     6480

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgccc     6540

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     6600

gcagagaggg agtggccaa                                                  6619


<210>  24
<211>  3744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid sequence


<220>
<221>  misc_feature
<222>  (1)..(3744)
<223>  pTR-UphUBE3 ITR-ITR sequence (bottom strand)

<400>  24
gggttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc       60

gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagagaggga      120

gtggccaact ccatcactag gggttcctag atctctcccc agcatgcctg ctattgtctt      180

cccaatcctc ccccttgctg tcctgcccca ccccaccccc cagaatagaa tgacacctac      240

tcagacaatg cgatgcaatt tcctcatttt attaggaaag gacagtggga gtggcacctt      300

ccagggtcaa ggaaggcacg ggggaggggc aaacaacaga tggctggcaa ctagaaggca      360

cagtcgaggc tgatcagcga gctctagtcg acatcgatat gcatcccggg gctagcttac      420

agcatgccaa atcctttggc atacgtgatg gccttcaaca atctctcttt aagtttttct      480

ttgcttgagt attccggaag taaaagcaca ttaaagcaag tatgagatgt aggtaacctt      540

tctgtgtctg ggccattttt ggctataatc atctttaatt ttcctagtcc tcccacaggt      600

gctctgtctg tgcccgttgt aaactgcaag aagagtcttt tctgttcatc tgtaaatgaa      660

tgaacgattt cccagaactc cctaatcaga acagagtccc tggtatagcc accgtcatat      720

tctgtagttt cttctagtgc ttggaaatct agattccggc ttccacatat aagcaattca      780

atttcttctg gtctgaataa gtactttaag ggagattcat tggtcaccat atgaaaacct      840

ctccgaaaag ccttgaactg tttttctact gatttattga gaatgtagtc agaataaaga      900

ttgacaaatt ccttcctgtt ttcatttgta attggaattt tatcaccatt ttcctttaga      960

tcatacatca ttgggttacc aaaaagatct gtctgtgata tctggaaagt gatcatcatg     1020

tcatcttcca cattcccttc atactccaat aaatctttta aactctgata tagaactggg     1080

tgagagtctc ccaagtcacg aaaagttcct tttttcccca ttagcttcct gtagacaacc     1140

atgggaaaat gtacatccag tatacagtta ttgtaaatag ccagacccag tactatgcca     1200

atcagagtaa actgaccctc agtttcaaaa gaagatggat taaaccaaaa caattttgta     1260

gattcatcgt atgtgaacat accaatatct ggattgaaga tttcctccac aaccagctga     1320

aaaaattctt tggaaacacc tccctcatca actccttgtt ctccttcaaa ttccacatac     1380

aactgcttct tcaagtctgc aggattttcc atagcgatca tctctagccg gacaagtgca     1440

tcatctatga tatggtcacg tctaactttg agtctcaaat atggattcaa ctgctgtcct     1500

tgaactaagc tgtagagaac agtgattctt cgttcactgt acatgcgaat tctattgtca     1560

taatataatc ccaaattctt tgtgacagca ttcaatataa agggacatgt cataaaagag     1620

aatttgttct ctgtttctac tttgaaaaaa gtataatctt tatccatttc tagaacctca     1680

ttcagtggtt cattaataaa ctcttcaaaa gggataagtg gttttcgaca atccagggtt     1740

ttaacaccaa gttcagtttc cagggggtcc actcgaggac ctttcttgtt tcttctttct     1800

tctcccaaaa gttcctgaag tgtcagctcg ctggactcag ggatgggctc ttcatcatct     1860

tcttcattgt gatttgtgtc cacttcccct cccactacat ttgcatagta aaccattttc     1920

aagcacttcg aagcagcaac aatggcatca tcatcattca ctagatttcg actgttaaat     1980

tcattgctta tgactttata agtaataagt tgctgaaatg tctccatcat tctccgaatc     2040

tggtctgcat tgtatttaga ccacagtctg atcagttttc cttgggctgc aaggggtagc     2100

ttgctcatcg ctttgcaaaa taatggcaaa gccatttcca gatattcagg actgtggaga     2160

tttctattct ccattacgat aatgaacaaa ttcagataat taggatctcg agagtataca     2220

ttgtgatacg tcaagtcaca ttccacgtta ggtgacaaat atacaagtgc attgagaaag     2280

gcagtttcaa ttttttcatt agagagcaat ctggtgtaga cccttctaat ggcatcaata     2340

tccacagaca catcatcagg gcctaatttt tgcaaattgt tgtctccctg tgagctatca     2400

cctatccttg aggaagatgc ttctgagtct tcttccatag cagcagcaga acatgcagct     2460

ttttcctttt catcttcatc tttgtcttca tcttttgctt gaagagattt cagttcttcc     2520

ttggtgtgtt gtttaacttt ccggaagctc tgtaccaatg cctcagcact agaaaaaact     2580

cttccaataa cacggattaa aggggaataa tcctctcttt ctctacataa ttcaagaatt     2640

tcatatacct tctcttctgt taagtaagtc acatctttaa aatcaattct agcgcctttc     2700

ttgttcattt ttatctcaga gcaggagttg ttgggggcac ctttcgagtt ctcaaggtaa     2760

gctgagcttg ctcctttctt ggagggatga ggatcacaga gttttgcatt aatcttataa     2820

agctcgaggg ctttaatagc tgctgcatta ttatccatac gaagaaaagt tggacaggaa     2880

gcacaaaact cattcgtgca ggcttcattt ccacagccct cagttaactg gtggtagtag     2940

cgttctatta gatgctttgc agctgctcgc ttcatggtgg accggtaagc ttcgtctaac     3000

aaaaaagcca aaaacggcca gaatttagcg gacaatttac tagtctaaca ctgaaaatta     3060

catattgacc caaatgatta catttcaaaa ggtgcctaaa aaacttcaca aaacacactc     3120

gccaaccccg agcgcacgta cccagcccag cagcccgcta ctcaccaagt gacgatcaca     3180

gcgatccaca aacaagaacc gcgacccaaa tcccggctgc gacggaacta gctgtgccac     3240

acccggcgcg tccttatata atcatcggcg ttcaccgccc cacggagatc cctccgcaga     3300

atcgccgaga agggactact tttcctcgcc tgttccgctc tctggaaaga aaaccagtgc     3360

cctagagtca cccaagtccc gtcctaaaat gtccttctgc tgatactggg gttctaaggc     3420

cgagtcttat gagcagcggg ccgctgtcct gagcgtccgg gcggaaggat caggacgctc     3480

gctgcgccct tcgtctgacg tggcagcgct cgccgtgagg aggggggcgc ccgcgggagg     3540

cgccaaaacc cggcgcggag gccggccggc cttaattaag cgatcgcgaa ttcagatcta     3600

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     3660

cgcccgggca aagcccgggc gtcgggcgac ctttggtcgc ccggcctcag tgagcgagcg     3720

agcgcgcaga gagggagtgg ccaa                                            3744


<210>  25
<211>  2559
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2559)
<223>  UBE3Av1 coding region

<400>  25
atgaagcgag cagctgcaaa gcatctaata gaacgctact accaccagtt aactgagggc       60

tgtggaaatg aagcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg      120

gataataatg cagcagctat taaagccctc gagctttata agattaatgc aaaactctgt      180

gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc gaaaggtgcc      240

cccaacaact cctgctctga gataaaaatg aacaagaaag gcgctagaat tgattttaaa      300

gatgtgactt acttaacaga agagaaggta tatgaaattc ttgaattatg tagagaaaga      360

gaggattatt cccctttaat ccgtgttatt ggaagagttt tttctagtgc tgaggcattg      420

gtacagagct tccggaaagt taaacaacac accaaggaag aactgaaatc tcttcaagca      480

aaagatgaag acaaagatga ggatgaaaag gaaaaagctg catgttctgc tgctgctatg      540

gaagaagact cagaagcatc ttcctcaagg ataggtgata gctcacaggg agacaacaat      600

ttgcaaaaat taggccctga tgatgtgtct gtggatattg atgccattag aagggtctac      660

accagattgc tctctaatga aaaaattgaa actgcctttc tcaatgcact tgtatatttg      720

tcacctaacg tggaatgtga cttgacgtat cacaatgtat actctcgaga tcctaattat      780

ctgaatttgt tcattatcgt aatggagaat agaaatctcc acagtcctga atatctggaa      840

atggctttgc cattattttg caaagcgatg agcaagctac cccttgcagc ccaaggaaaa      900

ctgatcagac tgtggtctaa atacaatgca gaccagattc ggagaatgat ggagacattt      960

cagcaactta ttacttataa agtcataagc aatgaattta acagtcgaaa tctagtgaat     1020

gatgatgatg ccattgttgc tgcttcgaag tgcttgaaaa tggtttacta tgcaaatgta     1080

gtgggagggg aagtggacac aaatcacaat gaagaagatg atgaagagcc catccctgag     1140

tccagcgagc tgacacttca ggaacttttg ggagaagaaa gaagaaacaa gaaaggtcct     1200

cgagtggacc ccctggaaac tgaacttggt gttaaaaccc tggattgtcg aaaaccactt     1260

atcccttttg aagagtttat taatgaacca ctgaatgagg ttctagaaat ggataaagat     1320

tatacttttt tcaaagtaga aacagagaac aaattctctt ttatgacatg tccctttata     1380

ttgaatgctg tcacaaagaa tttgggatta tattatgaca atagaattcg catgtacagt     1440

gaacgaagaa tcactgttct ctacagctta gttcaaggac agcagttgaa tccatatttg     1500

agactcaaag ttagacgtga ccatatcata gatgatgcac ttgtccggct agagatgatc     1560

gctatggaaa atcctgcaga cttgaagaag cagttgtatg tggaatttga aggagaacaa     1620

ggagttgatg agggaggtgt ttccaaagaa ttttttcagc tggttgtgga ggaaatcttc     1680

aatccagata ttggtatgtt cacatacgat gaatctacaa aattgttttg gtttaatcca     1740

tcttcttttg aaactgaggg tcagtttact ctgattggca tagtactggg tctggctatt     1800

tacaataact gtatactgga tgtacatttt cccatggttg tctacaggaa gctaatgggg     1860

aaaaaaggaa cttttcgtga cttgggagac tctcacccag ttctatatca gagtttaaaa     1920

gatttattgg agtatgaagg gaatgtggaa gatgacatga tgatcacttt ccagatatca     1980

cagacagatc tttttggtaa cccaatgatg tatgatctaa aggaaaatgg tgataaaatt     2040

ccaattacaa atgaaaacag gaaggaattt gtcaatcttt attctgacta cattctcaat     2100

aaatcagtag aaaaacagtt caaggctttt cggagaggtt ttcatatggt gaccaatgaa     2160

tctcccttaa agtacttatt cagaccagaa gaaattgaat tgcttatatg tggaagccgg     2220

aatctagatt tccaagcact agaagaaact acagaatatg acggtggcta taccagggac     2280

tctgttctga ttagggagtt ctgggaaatc gttcattcat ttacagatga acagaaaaga     2340

ctcttcttgc agtttacaac gggcacagac agagcacctg tgggaggact aggaaaatta     2400

aagatgatta tagccaaaaa tggcccagac acagaaaggt tacctacatc tcatacttgc     2460

tttaatgtgc ttttacttcc ggaatactca agcaaagaaa aacttaaaga gagattgttg     2520

aaggccatca cgtatgccaa aggatttggc atgctgtaa                            2559


<210>  26
<211>  2559
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2599)
<223>  UBE3Av1 cDNA coding strand (bottom strand)

<400>  26
ttacagcatg ccaaatcctt tggcatacgt gatggccttc aacaatctct ctttaagttt       60

ttctttgctt gagtattccg gaagtaaaag cacattaaag caagtatgag atgtaggtaa      120

cctttctgtg tctgggccat ttttggctat aatcatcttt aattttccta gtcctcccac      180

aggtgctctg tctgtgcccg ttgtaaactg caagaagagt cttttctgtt catctgtaaa      240

tgaatgaacg atttcccaga actccctaat cagaacagag tccctggtat agccaccgtc      300

atattctgta gtttcttcta gtgcttggaa atctagattc cggcttccac atataagcaa      360

ttcaatttct tctggtctga ataagtactt taagggagat tcattggtca ccatatgaaa      420

acctctccga aaagccttga actgtttttc tactgattta ttgagaatgt agtcagaata      480

aagattgaca aattccttcc tgttttcatt tgtaattgga attttatcac cattttcctt      540

tagatcatac atcattgggt taccaaaaag atctgtctgt gatatctgga aagtgatcat      600

catgtcatct tccacattcc cttcatactc caataaatct tttaaactct gatatagaac      660

tgggtgagag tctcccaagt cacgaaaagt tccttttttc cccattagct tcctgtagac      720

aaccatggga aaatgtacat ccagtataca gttattgtaa atagccagac ccagtactat      780

gccaatcaga gtaaactgac cctcagtttc aaaagaagat ggattaaacc aaaacaattt      840

tgtagattca tcgtatgtga acataccaat atctggattg aagatttcct ccacaaccag      900

ctgaaaaaat tctttggaaa cacctccctc atcaactcct tgttctcctt caaattccac      960

atacaactgc ttcttcaagt ctgcaggatt ttccatagcg atcatctcta gccggacaag     1020

tgcatcatct atgatatggt cacgtctaac tttgagtctc aaatatggat tcaactgctg     1080

tccttgaact aagctgtaga gaacagtgat tcttcgttca ctgtacatgc gaattctatt     1140

gtcataatat aatcccaaat tctttgtgac agcattcaat ataaagggac atgtcataaa     1200

agagaatttg ttctctgttt ctactttgaa aaaagtataa tctttatcca tttctagaac     1260

ctcattcagt ggttcattaa taaactcttc aaaagggata agtggttttc gacaatccag     1320

ggttttaaca ccaagttcag tttccagggg gtccactcga ggacctttct tgtttcttct     1380

ttcttctccc aaaagttcct gaagtgtcag ctcgctggac tcagggatgg gctcttcatc     1440

atcttcttca ttgtgatttg tgtccacttc ccctcccact acatttgcat agtaaaccat     1500

tttcaagcac ttcgaagcag caacaatggc atcatcatca ttcactagat ttcgactgtt     1560

aaattcattg cttatgactt tataagtaat aagttgctga aatgtctcca tcattctccg     1620

aatctggtct gcattgtatt tagaccacag tctgatcagt tttccttggg ctgcaagggg     1680

tagcttgctc atcgctttgc aaaataatgg caaagccatt tccagatatt caggactgtg     1740

gagatttcta ttctccatta cgataatgaa caaattcaga taattaggat ctcgagagta     1800

tacattgtga tacgtcaagt cacattccac gttaggtgac aaatatacaa gtgcattgag     1860

aaaggcagtt tcaatttttt cattagagag caatctggtg tagacccttc taatggcatc     1920

aatatccaca gacacatcat cagggcctaa tttttgcaaa ttgttgtctc cctgtgagct     1980

atcacctatc cttgaggaag atgcttctga gtcttcttcc atagcagcag cagaacatgc     2040

agctttttcc ttttcatcct catctttgtc ttcatctttt gcttgaagag atttcagttc     2100

ttccttggtg tgttgtttaa ctttccggaa gctctgtacc aatgcctcag cactagaaaa     2160

aactcttcca ataacacgga ttaaagggga ataatcctct ctttctctac ataattcaag     2220

aatttcatat accttctctt ctgttaagta agtcacatct ttaaaatcaa ttctagcgcc     2280

tttcttgttc atttttatct cagagcagga gttgttgggg gcacctttcg agttctcaag     2340

gtaagctgag cttgctcctt tcttggaggg atgaggatca cagagttttg cattaatctt     2400

ataaagctcg agggctttaa tagctgctgc attattatcc atacgaagaa aagttggaca     2460

ggaagcacaa aactcattcg tgcaggcttc atttccacag ccctcagtta actggtggta     2520

gtagcgttct attagatgct ttgcagctgc tcgcttcat                            2559


<210>  27
<211>  736
<212>  PRT
<213>  adeno-associated virus 9


<220>
<221>  PEPTIDE
<222>  (1)..(660)
<223>  AAV 9.2 VP1 capsid protein

<400>  27

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Phe Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Phe Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  28
<211>  736
<212>  PRT
<213>  adeno-associated virus 9


<220>
<221>  Peptide
<222>  (1)..(736)
<223>  wt AAV 9 VPI protein

<400>  28

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  29
<211>  736
<212>  PRT
<213>  adeno-associated virus 9


<220>
<221>  PEPTIDE
<222>  (1)..(736)
<223>  AAV9 VP1 protein

<220>
<221>  MISC_FEATURE
<222>  (446)..(446)
<223>  X= Y or F

<220>
<221>  MISC_FEATURE
<222>  (731)..(731)
<223>  X= Y or F

<400>  29

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Xaa Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Xaa Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  30
<211>  2208
<212>  DNA
<213>  adeno-associated virus 9


<220>
<221>  misc_feature
<222>  (1)..(2208)
<223>  AAV 9.1 VP1 capsid cDNA

<400>  30
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactttct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctg                  2208


<210>  31
<211>  2208
<212>  DNA
<213>  adeno-associated virus 9


<220>
<221>  misc_feature
<222>  (1)..(2208)
<223>  AAV 9.1 cDNA (bottom strand)

<400>  31
cagattacga gtcaggtatc tggtgccaat ggggcggggt tcactatata caccttcagt       60

attaacagca aattcaacat tattagactt gtaatagttg gaagtgtact ggatctccgg      120

gttccagcgc ttgctgtttt ccttctgcag ctcccactcg atctccacgc tgacttggcc      180

agtagaatac tgggtgatga aagagttcag cttgtccttg ttgaaggccg ttggaggatc      240

cgcaggtaca ggtgtgtttt tgatgaggat ctgaggaggc gggtgcttca ttccaaaccc      300

tcccatcagc ggagaagggt gaaagttgcc gtccgtgtga ggaattttgg cccaaatggg      360

tccttgcagg tacacatctc tgtcctgcca aaccataccc ggaagtattc cttggttttg      420

aacccagccg gtctgcgcct gtgcttgggc actctggtgg tttgtggcca cttgtccata      480

ggactccgtt gctaccgggt tagtagtttt aatttcttct tcgttggtta tcatgacttt      540

gtccgcatcc acgttgtctc ttccagttcc ttgtttgcca aaaattaaag atccagacaa      600

aggaaagaaa cggtcctctc cttctttgtg gctggccata gcaggtccag gattcatcaa      660

gctattacgt ccattgagag cccaagaaga agctccaggc caagcaaatt cgctgttgtt      720

gttttgagtc acagtggttg agacacgttg ttgtcggtag ctgggtccag gtatgtagtt      780

tcttccctgg acagccatgt tgctgggtcc ggccacactg aattttagcg tttgttgatt      840

ctgtccagaa ccgttaatag tctttgagag aaagtacaag tattggtcga tgagtggatt      900

cattagtcgg tccaggcttt ggctgtgagc gtagctgcta tggaaaggta cgttctcaaa      960

ctcgtagctg aactggaagt tgttacccgt tcttagcatt tgcgacggga aatattccag     1020

gcagtaaaag gacgaacgac ccacggcctg gcttccatca ttaagcgtca gatacccgta     1080

ctgaggaatc atgaaaacgt ccgctgggaa cggcgggagg cagccctcgt gagccgaccc     1140

gagcacgtac gggagctgat agtctgagtc cgtgaagacc tggaccgtgc tggtaaggtt     1200

attggcgatg gtcttgactc cattgttgtc cgtaacctct ttgacctgaa tgttgaagag     1260

cttgaagttg agtcgcttag gccggaatcc ccagttgttg ttgatgagtc gctgccagtc     1320

acgtggtgag aagtggcagt ggaatctgtt gaagtcaaaa tacccccagg gggtgctgta     1380

gccgaagtag gcgttgtcat ttgaagatcc tccagatgtg ctgttggaga tttgcttgta     1440

gaggtgattg ttgtaggtgg gcagggccca ggttcgggtg ctggtggtga tgactctgtc     1500

ccccagccat tgggaatcgc aatgccaatt tcccgaggaa ctacccactc catcggcacc     1560

ttcgttattg tctgccactg gtgcgccacc acctgaagcc attgtaagag atcccacacc     1620

tgagggggct gcgggaggtt ctccgattgg ttgagggtct gggactgact ctgtgtcgcc     1680

agtctgaccg aaattgagtc tctttttagc gggctgtgca cccgatttgc caatacccgc     1740

ggaggagtcc ggttcctgag gagactgctc tacaggcctc ttctttccag gagccgtctt     1800

agccgcttcc tcaaccagac caagaggttc aagaagcctc tttttggcct ggaagactgc     1860

tcgcccgagg ttgcccccaa aagacgtatc ttctttgagc cgctcctgga actcggcgtc     1920

ggcgtggttg tacttgaggt acgggttgtc tccggccttg agctgctggt cgtaggcctt     1980

gtcgtgctcg agggccgccg cgtctgctgc gttgaccggc tcccccttgt cgagtccgtt     2040

gccgggtcca aggtatttgt aacccggaag cacaagacct cgagcgttgt cttgatgttg     2100

ttgatttgcc ttgggttgag gggctccagg tttcaaagcc caccactcgc gaattccttc     2160

actaaggttg tcctcgagcc aatctggaag ataaccatcg gcagccat                  2208


<210>  32
<211>  736
<212>  PRT
<213>  adeno-associated virus 9


<220>
<221>  peptide
<222>  (1)..(736)
<223>  AAV 9.1 VP1 capsid protein

<400>  32

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Phe Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  33
<211>  2208
<212>  DNA
<213>  adeno-associated virus 9


<220>
<221>  misc_feature
<222>  (1)..(2208)
<223>  AAV 9.2 VP1 cDNA

<400>  33
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactttct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga ttcctgactc gtaatctg                  2208


<210>  34
<211>  2208
<212>  DNA
<213>  adeno-associated virus 9


<220>
<221>  misc_feature
<222>  (1)..(2208)
<223>  AAV 9.2 VP1 cDNA (bottom strand)

<400>  34
cagattacga gtcaggaatc tggtgccaat ggggcggggt tcactatata caccttcagt       60

attaacagca aattcaacat tattagactt gtaatagttg gaagtgtact ggatctccgg      120

gttccagcgc ttgctgtttt ccttctgcag ctcccactcg atctccacgc tgacttggcc      180

agtagaatac tgggtgatga aagagttcag cttgtccttg ttgaaggccg ttggaggatc      240

cgcaggtaca ggtgtgtttt tgatgaggat ctgaggaggc gggtgcttca ttccaaaccc      300

tcccatcagc ggagaagggt gaaagttgcc gtccgtgtga ggaattttgg cccaaatggg      360

tccttgcagg tacacatctc tgtcctgcca aaccataccc ggaagtattc cttggttttg      420

aacccagccg gtctgcgcct gtgcttgggc actctggtgg tttgtggcca cttgtccata      480

ggactccgtt gctaccgggt tagtagtttt aatttcttct tcgttggtta tcatgacttt      540

gtccgcatcc acgttgtctc ttccagttcc ttgtttgcca aaaattaaag atccagacaa      600

aggaaagaaa cggtcctctc cttctttgtg gctggccata gcaggtccag gattcatcaa      660

gctattacgt ccattgagag cccaagaaga agctccaggc caagcaaatt cgctgttgtt      720

gttttgagtc acagtggttg agacacgttg ttgtcggtag ctgggtccag gtatgtagtt      780

tcttccctgg acagccatgt tgctgggtcc ggccacactg aattttagcg tttgttgatt      840

ctgtccagaa ccgttaatag tctttgagag aaagtacaag tattggtcga tgagtggatt      900

cattagtcgg tccaggcttt ggctgtgagc gtagctgcta tggaaaggta cgttctcaaa      960

ctcgtagctg aactggaagt tgttacccgt tcttagcatt tgcgacggga aatattccag     1020

gcagtaaaag gacgaacgac ccacggcctg gcttccatca ttaagcgtca gatacccgta     1080

ctgaggaatc atgaaaacgt ccgctgggaa cggcgggagg cagccctcgt gagccgaccc     1140

gagcacgtac gggagctgat agtctgagtc cgtgaagacc tggaccgtgc tggtaaggtt     1200

attggcgatg gtcttgactc cattgttgtc cgtaacctct ttgacctgaa tgttgaagag     1260

cttgaagttg agtcgcttag gccggaatcc ccagttgttg ttgatgagtc gctgccagtc     1320

acgtggtgag aagtggcagt ggaatctgtt gaagtcaaaa tacccccagg gggtgctgta     1380

gccgaagtag gcgttgtcat ttgaagatcc tccagatgtg ctgttggaga tttgcttgta     1440

gaggtgattg ttgtaggtgg gcagggccca ggttcgggtg ctggtggtga tgactctgtc     1500

ccccagccat tgggaatcgc aatgccaatt tcccgaggaa ctacccactc catcggcacc     1560

ttcgttattg tctgccactg gtgcgccacc acctgaagcc attgtaagag atcccacacc     1620

tgagggggct gcgggaggtt ctccgattgg ttgagggtct gggactgact ctgtgtcgcc     1680

agtctgaccg aaattgagtc tctttttagc gggctgtgca cccgatttgc caatacccgc     1740

ggaggagtcc ggttcctgag gagactgctc tacaggcctc ttctttccag gagccgtctt     1800

agccgcttcc tcaaccagac caagaggttc aagaagcctc tttttggcct ggaagactgc     1860

tcgcccgagg ttgcccccaa aagacgtatc ttctttgagc cgctcctgga actcggcgtc     1920

ggcgtggttg tacttgaggt acgggttgtc tccggccttg agctgctggt cgtaggcctt     1980

gtcgtgctcg agggccgccg cgtctgctgc gttgaccggc tcccccttgt cgagtccgtt     2040

gccgggtcca aggtatttgt aacccggaag cacaagacct cgagcgttgt cttgatgttg     2100

ttgatttgcc ttgggttgag gggctccagg tttcaaagcc caccactcgc gaattccttc     2160

actaaggttg tcctcgagcc aatctggaag ataaccatcg gcagccat                  2208


<210>  35
<211>  183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA fragment encoding AZUL domain


<220>
<221>  misc_feature
<222>  (1)..(183)
<223>  Azul domain

<400>  35
atgaagcgag cagctgcaaa gcatctaata gaacgctact accaccagtt aactgagggc       60

tgtggaaatg aagcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg      120

gataataatg cagcagctat taaagccctc gagctttata agattaatgc aaaactctgt      180

gat                                                                    183


<210>  36
<211>  183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Azul domain cDNA (bottom strand)


<220>
<221>  misc_feature
<222>  (1)..(183)
<223>  Azul domain (bottom strand)

<400>  36
atcacagagt tttgcattaa tcttataaag ctcgagggct ttaatagctg ctgcattatt       60

atccatacga agaaaagttg gacaggaagc acaaaactca ttcgtgcagg cttcatttcc      120

acagccctca gttaactggt ggtagtagcg ttctattaga tgctttgcag ctgctcgctt      180

cat                                                                    183


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  37
taaattctgg ccgtttttgg                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  38
catttccaca gccctcagtt                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39
catttccaca gccctcagtt                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  40
attcgtgcag gcttcatttc                                                   20


<210>  41
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDNF gene fragment encoding secretion sequence

<400>  41
atgaagttat gggatgtcgt ggctgtctgc ctggtgctgc tccacaccgc gtccgc           56


<210>  42
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Insulin gene fragment encoding secretion sequence

<400>  42
atggccctgt ggatgcgcct cctgcccctg ctggcgctgc tggccctctg gggacctgac       60

ccagccgcag cc                                                           72


<210>  43
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgK gene fragment encoding secretion sequence

<400>  43
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60


<210>  44
<211>  3792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid sequence (ITR-ITR sequence of pUphUbeKan)


<220>
<221>  misc_feature
<222>  (1)..(3792)
<223>  ITR-ITR nucleotide sequence of the pUphUbe/kan plasmid

<400>  44
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttaactataa cggtcctaag gtagcgagcg atcgcttaat      180

taaggccggc cggcctccgc gccgggtttt ggcgcctccc gcgggcgccc ccctcctcac      240

ggcgagcgct gccacgtcag acgaagggcg cagcgagcgt cctgatcctt ccgcccggac      300

gctcaggaca gcggcccgct gctcataaga ctcggcctta gaaccccagt atcagcagaa      360

ggacatttta ggacgggact tgggtgactc tagggcactg gttttctttc cagagagcgg      420

aacaggcgag gaaaagtagt cccttctcgg cgattctgcg gagggatctc cgtggggcgg      480

tgaacgccga tgattatata aggacgcgcc gggtgtggca cagctagttc cgtcgcagcc      540

gggatttggg tcgcggttct tgtttgtgga tcgctgtgat cgtcacttgg tgagtagcgg      600

gctgctgggc tgggtacgtg cgctcggggt tggcgagtgt gttttgtgaa gttttttagg      660

caccttttga aatgtaatca tttgggtcaa tatgtaattt tcagtgttag actagtaaat      720

tgtccgctaa attctggccg tttttggctt ttttgttaga cgcctgcagg ggcgcgccac      780

gcgtaagctt accggtccac catgaagcga gcagctgcaa agcatctaat agaacgctac      840

taccaccagt taactgaggg ctgtggaaat gaagcctgca cgaatgagtt ttgtgcttcc      900

tgtccaactt ttcttcgtat ggataataat gcagcagcta ttaaagccct cgagctttat      960

aagattaatg caaaactctg tgatcctcat ccctccaaga aaggagcaag ctcagcttac     1020

cttgagaact cgaaaggtgc ccccaacaac tcctgctctg agataaaaat gaacaagaaa     1080

ggcgctagaa ttgattttaa agatgtgact tacttaacag aagagaaggt atatgaaatt     1140

cttgaattat gtagagaaag agaggattat tcccctttaa tccgtgttat tggaagagtt     1200

ttttctagtg ctgaggcatt ggtacagagc ttccggaaag ttaaacaaca caccaaggaa     1260

gaactgaaat ctcttcaagc aaaagatgaa gacaaagatg aagatgaaaa ggaaaaagct     1320

gcatgttctg ctgctgctat ggaagaagac tcagaagcat cttcctcaag gataggtgat     1380

agctcacagg gagacaacaa tttgcaaaaa ttaggccctg atgatgtgtc tgtggatatt     1440

gatgccatta gaagggtcta caccagattg ctctctaatg aaaaaattga aactgccttt     1500

ctcaatgcac ttgtatattt gtcacctaac gtggaatgtg acttgacgta tcacaatgta     1560

tactctcgag atcctaatta tctgaatttg ttcattatcg taatggagaa tagaaatctc     1620

cacagtcctg aatatctgga aatggctttg ccattatttt gcaaagcgat gagcaagcta     1680

ccccttgcag cccaaggaaa actgatcaga ctgtggtcta aatacaatgc agaccagatt     1740

cggagaatga tggagacatt tcagcaactt attacttata aagtcataag caatgaattt     1800

aacagtcgaa atctagtgaa tgatgatgat gccattgttg ctgcttcgaa gtgcttgaaa     1860

atggtttact atgcaaatgt agtgggaggg gaagtggaca caaatcacaa tgaagaagat     1920

gatgaagagc ccatccctga gtccagcgag ctgacacttc aggaactttt gggagaagaa     1980

agaagaaaca agaaaggtcc tcgagtggac cccctggaaa ctgaacttgg tgttaaaacc     2040

ctggattgtc gaaaaccact tatccctttt gaagagttta ttaatgaacc actgaatgag     2100

gttctagaaa tggataaaga ttatactttt ttcaaagtag aaacagagaa caaattctct     2160

tttatgacat gtccctttat attgaatgct gtcacaaaga atttgggatt atattatgac     2220

aatagaattc gcatgtacag tgaacgaaga atcactgttc tctacagctt agttcaagga     2280

cagcagttga atccatattt gagactcaaa gttagacgtg accatatcat agatgatgca     2340

cttgtccggc tagagatgat cgctatggaa aatcctgcag acttgaagaa gcagttgtat     2400

gtggaatttg aaggagaaca aggagttgat gagggaggtg tttccaaaga attttttcag     2460

ctggttgtgg aggaaatctt caatccagat attggtatgt tcacatacga tgaatctaca     2520

aaattgtttt ggtttaatcc atcttctttt gaaactgagg gtcagtttac tctgattggc     2580

atagtactgg gtctggctat ttacaataac tgtatactgg atgtacattt tcccatggtt     2640

gtctacagga agctaatggg gaaaaaagga acttttcgtg acttgggaga ctctcaccca     2700

gttctatatc agagtttaaa agatttattg gagtatgaag ggaatgtgga agatgacatg     2760

atgatcactt tccagatatc acagacagat ctttttggta acccaatgat gtatgatcta     2820

aaggaaaatg gtgataaaat tccaattaca aatgaaaaca ggaaggaatt tgtcaatctt     2880

tattctgact acattctcaa taaatcagta gaaaaacagt tcaaggcttt tcggagaggt     2940

tttcatatgg tgaccaatga atctccctta aagtacttat tcagaccaga agaaattgaa     3000

ttgcttatat gtggaagccg gaatctagat ttccaagcac tagaagaaac tacagaatat     3060

gacggtggct ataccaggga ctctgttctg attagggagt tctgggaaat cgttcattca     3120

tttacagatg aacagaaaag actcttcttg cagtttacaa cgggcacaga cagagcacct     3180

gtgggaggac taggaaaatt aaagatgatt atagccaaaa atggcccaga cacagaaagg     3240

ttacctacat ctcatacttg ctttaatgtg cttttacttc cggaatactc aagcaaagaa     3300

aaacttaaag agagattgtt gaaggccatc acgtatgcca aaggatttgg catgctgtaa     3360

gctagccccg ggatgcatat cgatgtcgac tagagctcgc tgatcagcct cgactgtgcc     3420

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     3480

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     3540

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     3600

caatagcagg catgctgggg agagatctag gaaattaccc tgttatccct aaggaacccc     3660

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     3720

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     3780

gctgcctgca gg                                                         3792


<210>  45
<211>  3792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid sequence


<220>
<221>  misc_feature
<222>  (1)..(3792)
<223>  ITR-ITR nucleotide sequence of the pUphUbe/kan plasmid (bottom 
       strand)

<400>  45
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttagggataa cagggtaatt tcctagatct ctccccagca      180

tgcctgctat tgtcttccca atcctccccc ttgctgtcct gccccacccc accccccaga      240

atagaatgac acctactcag acaatgcgat gcaatttcct cattttatta ggaaaggaca      300

gtgggagtgg caccttccag ggtcaaggaa ggcacggggg aggggcaaac aacagatggc      360

tggcaactag aaggcacagt cgaggctgat cagcgagctc tagtcgacat cgatatgcat      420

cccggggcta gcttacagca tgccaaatcc tttggcatac gtgatggcct tcaacaatct      480

ctctttaagt ttttctttgc ttgagtattc cggaagtaaa agcacattaa agcaagtatg      540

agatgtaggt aacctttctg tgtctgggcc atttttggct ataatcatct ttaattttcc      600

tagtcctccc acaggtgctc tgtctgtgcc cgttgtaaac tgcaagaaga gtcttttctg      660

ttcatctgta aatgaatgaa cgatttccca gaactcccta atcagaacag agtccctggt      720

atagccaccg tcatattctg tagtttcttc tagtgcttgg aaatctagat tccggcttcc      780

acatataagc aattcaattt cttctggtct gaataagtac tttaagggag attcattggt      840

caccatatga aaacctctcc gaaaagcctt gaactgtttt tctactgatt tattgagaat      900

gtagtcagaa taaagattga caaattcctt cctgttttca tttgtaattg gaattttatc      960

accattttcc tttagatcat acatcattgg gttaccaaaa agatctgtct gtgatatctg     1020

gaaagtgatc atcatgtcat cttccacatt cccttcatac tccaataaat cttttaaact     1080

ctgatataga actgggtgag agtctcccaa gtcacgaaaa gttccttttt tccccattag     1140

cttcctgtag acaaccatgg gaaaatgtac atccagtata cagttattgt aaatagccag     1200

acccagtact atgccaatca gagtaaactg accctcagtt tcaaaagaag atggattaaa     1260

ccaaaacaat tttgtagatt catcgtatgt gaacatacca atatctggat tgaagatttc     1320

ctccacaacc agctgaaaaa attctttgga aacacctccc tcatcaactc cttgttctcc     1380

ttcaaattcc acatacaact gcttcttcaa gtctgcagga ttttccatag cgatcatctc     1440

tagccggaca agtgcatcat ctatgatatg gtcacgtcta actttgagtc tcaaatatgg     1500

attcaactgc tgtccttgaa ctaagctgta gagaacagtg attcttcgtt cactgtacat     1560

gcgaattcta ttgtcataat ataatcccaa attctttgtg acagcattca atataaaggg     1620

acatgtcata aaagagaatt tgttctctgt ttctactttg aaaaaagtat aatctttatc     1680

catttctaga acctcattca gtggttcatt aataaactct tcaaaaggga taagtggttt     1740

tcgacaatcc agggttttaa caccaagttc agtttccagg gggtccactc gaggaccttt     1800

cttgtttctt ctttcttctc ccaaaagttc ctgaagtgtc agctcgctgg actcagggat     1860

gggctcttca tcatcttctt cattgtgatt tgtgtccact tcccctccca ctacatttgc     1920

atagtaaacc attttcaagc acttcgaagc agcaacaatg gcatcatcat cattcactag     1980

atttcgactg ttaaattcat tgcttatgac tttataagta ataagttgct gaaatgtctc     2040

catcattctc cgaatctggt ctgcattgta tttagaccac agtctgatca gttttccttg     2100

ggctgcaagg ggtagcttgc tcatcgcttt gcaaaataat ggcaaagcca tttccagata     2160

ttcaggactg tggagatttc tattctccat tacgataatg aacaaattca gataattagg     2220

atctcgagag tatacattgt gatacgtcaa gtcacattcc acgttaggtg acaaatatac     2280

aagtgcattg agaaaggcag tttcaatttt ttcattagag agcaatctgg tgtagaccct     2340

tctaatggca tcaatatcca cagacacatc atcagggcct aatttttgca aattgttgtc     2400

tccctgtgag ctatcaccta tccttgagga agatgcttct gagtcttctt ccatagcagc     2460

agcagaacat gcagcttttt ccttttcatc ttcatctttg tcttcatctt ttgcttgaag     2520

agatttcagt tcttccttgg tgtgttgttt aactttccgg aagctctgta ccaatgcctc     2580

agcactagaa aaaactcttc caataacacg gattaaaggg gaataatcct ctctttctct     2640

acataattca agaatttcat ataccttctc ttctgttaag taagtcacat ctttaaaatc     2700

aattctagcg cctttcttgt tcatttttat ctcagagcag gagttgttgg gggcaccttt     2760

cgagttctca aggtaagctg agcttgctcc tttcttggag ggatgaggat cacagagttt     2820

tgcattaatc ttataaagct cgagggcttt aatagctgct gcattattat ccatacgaag     2880

aaaagttgga caggaagcac aaaactcatt cgtgcaggct tcatttccac agccctcagt     2940

taactggtgg tagtagcgtt ctattagatg ctttgcagct gctcgcttca tggtggaccg     3000

gtaagcttac gcgtggcgcg cccctgcagg cgtctaacaa aaaagccaaa aacggccaga     3060

atttagcgga caatttacta gtctaacact gaaaattaca tattgaccca aatgattaca     3120

tttcaaaagg tgcctaaaaa acttcacaaa acacactcgc caaccccgag cgcacgtacc     3180

cagcccagca gcccgctact caccaagtga cgatcacagc gatccacaaa caagaaccgc     3240

gacccaaatc ccggctgcga cggaactagc tgtgccacac ccggcgcgtc cttatataat     3300

catcggcgtt caccgcccca cggagatccc tccgcagaat cgccgagaag ggactacttt     3360

tcctcgcctg ttccgctctc tggaaagaaa accagtgccc tagagtcacc caagtcccgt     3420

cctaaaatgt ccttctgctg atactggggt tctaaggccg agtcttatga gcagcgggcc     3480

gctgtcctga gcgtccgggc ggaaggatca ggacgctcgc tgcgcccttc gtctgacgtg     3540

gcagcgctcg ccgtgaggag gggggcgccc gcgggaggcg ccaaaacccg gcgcggaggc     3600

cggccggcct taattaagcg atcgctcgct accttaggac cgttatagtt aaggaacccc     3660

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     3720

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     3780

gctgcctgca gg                                                         3792


<210>  46
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Azul domain peptide


<220>
<221>  PEPTIDE
<222>  (1)..(61)
<223>  Azul domain peptide

<400>  46

Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg Tyr Tyr His Gln 
1               5                   10                  15      


Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn Glu Phe Cys Ala 
            20                  25                  30          


Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala Ala Ala Ile Lys 
        35                  40                  45              


Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys Asp 
    50                  55                  60      


