                         SEQUENCE LISTING

<110>  Javelin Oncology, Inc.
       COOPER, Anthony B.
 
<120>  ANTI-ADAM12 ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS, AND 
       COMPOSITIONS AND METHODS COMPRISING

<130>  1156867.001613

<140>  To be assigned
<141>  Herewith

<150>  62/821,257
<151>  2019-03-20

<160>  297   

<170>  PatentIn version 3.5

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<210>  101
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Arg 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Asp Asn Gln Gly Leu Thr Ile Gly Ile Leu Val Thr Ile Leu Cys Leu 
705                 710                 715                 720 


Leu Ala Ala Gly Phe Val Val Tyr Leu Lys Arg Lys Thr Leu Ile Arg 
                725                 730                 735     


Leu Leu Phe Thr Asn Lys Lys Thr Thr Ile Glu Lys Leu Arg Cys Val 
            740                 745                 750         


Arg Pro Ser Arg Pro Pro Arg Gly Phe Gln Pro Cys Gln Ala His Leu 
        755                 760                 765             


Gly His Leu Gly Lys Gly Leu Met Arg Lys Pro Pro Asp Ser Tyr Pro 
    770                 775                 780                 


Pro Lys Asp Asn Pro Arg Arg Leu Leu Gln Cys Gln Asn Val Asp Ile 
785                 790                 795                 800 


Ser Arg Pro Leu Asn Gly Leu Asn Val Pro Gln Pro Gln Ser Thr Gln 
                805                 810                 815     


Arg Val Leu Pro Pro Leu His Arg Ala Pro Arg Ala Pro Ser Val Pro 
            820                 825                 830         


Ala Arg Pro Leu Pro Ala Lys Pro Ala Leu Arg Gln Ala Gln Gly Thr 
        835                 840                 845             


Cys Lys Pro Asn Pro Pro Gln Lys Pro Leu Pro Ala Asp Pro Leu Ala 
    850                 855                 860                 


Arg Thr Thr Arg Leu Thr His Ala Leu Ala Arg Thr Pro Gly Gln Trp 
865                 870                 875                 880 


Glu Thr Gly Leu Arg Leu Ala Pro Leu Arg Pro Ala Pro Gln Tyr Pro 
                885                 890                 895     


His Gln Val Pro Arg Ser Thr His Thr Ala Tyr Ile Lys 
            900                 905                 


<210>  102
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Arg 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Glu Ala Arg Gln Glu Ala Ala Glu Ser Asn Arg Glu Arg Gly Gln Gly 
705                 710                 715                 720 


Gln Glu Pro Val Gly Ser Gln Glu His Ala Ser Thr Ala Ser Leu Thr 
                725                 730                 735     


Leu Ile 
        


<210>  103
<211>  903
<212>  PRT
<213>  Mus musculus

<400>  103

Met Ala Glu Arg Pro Ala Arg Arg Ala Pro Pro Ala Arg Ala Leu Leu 
1               5                   10                  15      


Leu Ala Leu Ala Gly Ala Leu Leu Ala Pro Arg Ala Ala Arg Gly Met 
            20                  25                  30          


Ser Leu Trp Asp Gln Arg Gly Thr Tyr Glu Val Ala Arg Ala Ser Leu 
        35                  40                  45              


Leu Ser Lys Asp Pro Gly Ile Pro Gly Gln Ser Ile Pro Ala Lys Asp 
    50                  55                  60                  


His Pro Asp Val Leu Thr Val Gln Leu Gln Leu Glu Ser Arg Asp Leu 
65                  70                  75                  80  


Ile Leu Ser Leu Glu Arg Asn Glu Gly Leu Ile Ala Asn Gly Phe Thr 
                85                  90                  95      


Glu Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Thr Arg Asn 
            100                 105                 110         


His Thr Asp His Cys Tyr Tyr His Gly His Val Gln Gly Asp Ala Ala 
        115                 120                 125             


Ser Val Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu Ile Met 
    130                 135                 140                 


Phe Glu Asn Lys Thr Tyr Ser Leu Glu Pro Met Lys Asn Thr Thr Asp 
145                 150                 155                 160 


Ser Tyr Lys Leu Val Pro Ala Glu Ser Met Thr Asn Ile Gln Gly Leu 
                165                 170                 175     


Cys Gly Ser Gln His Asn Lys Ser Asn Leu Thr Met Glu Asp Val Ser 
            180                 185                 190         


Pro Gly Thr Ser Gln Met Arg Ala Arg Arg His Lys Arg Glu Thr Leu 
        195                 200                 205             


Lys Met Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn Arg Glu 
    210                 215                 220                 


Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg Leu Ile 
225                 230                 235                 240 


Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Ile Asp Lys Cys Ser 
            260                 265                 270         


Ile Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp Trp Arg 
        275                 280                 285             


Lys Ile Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln Leu Ile 
    290                 295                 300                 


Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro Ile Met 
305                 310                 315                 320 


Ser Met Cys Thr Ala Glu Gln Ser Gly Gly Val Val Met Asp His Ser 
                325                 330                 335     


Asp Ser Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu Gly His 
            340                 345                 350         


Asn Phe Gly Met Asn His Asp Thr Leu Glu Arg Gly Cys Ser Cys Arg 
        355                 360                 365             


Met Ala Ala Glu Lys Gly Gly Cys Ile Met Asn Pro Ser Thr Gly Phe 
    370                 375                 380                 


Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu Glu Ala 
385                 390                 395                 400 


Ser Leu Glu Lys Gly Met Gly Met Cys Leu Phe Asn Leu Pro Glu Val 
                405                 410                 415     


Lys Gln Ala Phe Gly Gly Arg Lys Cys Gly Asn Gly Tyr Val Glu Glu 
            420                 425                 430         


Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Thr Asn Arg Cys 
        435                 440                 445             


Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys Ala His 
    450                 455                 460                 


Gly Gln Cys Cys Glu Asp Cys Gln Leu Lys Pro Pro Gly Thr Ala Cys 
465                 470                 475                 480 


Arg Gly Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr 
                485                 490                 495     


Ala Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His Pro Cys 
            500                 505                 510         


Gln Gly Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr His Glu 
        515                 520                 525             


Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala Pro Gly 
    530                 535                 540                 


Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly Asn Cys 
545                 550                 555                 560 


Gly Lys Asp Ser Lys Ser Ala Phe Ala Lys Cys Glu Leu Arg Asp Ala 
                565                 570                 575     


Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro Val Ile 
            580                 585                 590         


Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Gln Gln Glu Gly 
        595                 600                 605             


Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp Asp Met 
    610                 615                 620                 


Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Glu Gly Lys 
625                 630                 635                 640 


Ile Cys Leu Asn Arg Arg Cys Gln Asn Ile Ser Val Phe Gly Val His 
                645                 650                 655     


Lys Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn Arg Lys 
            660                 665                 670         


Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp Lys Phe 
        675                 680                 685             


Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala Asp Asn 
    690                 695                 700                 


Gln Gly Leu Thr Val Gly Ile Leu Val Ser Ile Leu Cys Leu Leu Ala 
705                 710                 715                 720 


Ala Gly Phe Val Val Tyr Leu Lys Arg Lys Thr Leu Met Arg Leu Leu 
                725                 730                 735     


Phe Thr His Lys Lys Thr Thr Met Glu Lys Leu Arg Cys Val His Pro 
            740                 745                 750         


Ser Arg Thr Pro Ser Gly Pro His Leu Gly Gln Ala His His Thr Pro 
        755                 760                 765             


Gly Lys Gly Leu Leu Met Asn Arg Ala Pro His Phe Asn Thr Pro Lys 
    770                 775                 780                 


Asp Arg His Ser Leu Lys Cys Gln Asn Met Asp Ile Ser Arg Pro Leu 
785                 790                 795                 800 


Asp Ala Arg Ala Val Pro Gln Leu Gln Ser Pro Gln Arg Val Leu Leu 
                805                 810                 815     


Pro Leu His Gln Thr Pro Arg Ala Pro Ser Gly Pro Ala Arg Pro Leu 
            820                 825                 830         


Pro Ala Ser Pro Ala Val Arg Gln Ala Gln Gly Ile Arg Lys Pro Ser 
        835                 840                 845             


Pro Pro Gln Lys Pro Leu Pro Ala Asp Pro Leu Ser Arg Thr Ser Arg 
    850                 855                 860                 


Leu Thr Ser Ala Leu Val Arg Thr Pro Gly Gln Gln Glu Pro Gly His 
865                 870                 875                 880 


Arg Pro Ala Pro Ile Arg Pro Ala Pro Lys His Gln Val Pro Arg Pro 
                885                 890                 895     


Ser His Asn Ala Tyr Ile Lys 
            900             


<210>  104

<400>  104
000

<210>  105

<400>  105
000

<210>  106

<400>  106
000

<210>  107

<400>  107
000

<210>  108

<400>  108
000

<210>  109

<400>  109
000

<210>  110

<400>  110
000

<210>  111
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 Clone 6E6 Heavy chain variable

<400>  111

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Asn Thr Lys Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Thr Gln Val Phe Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Glu Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Tyr Phe Gly Ser Arg His Phe Tyr Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VH CDR 1

<400>  112

Gly Phe Ser Leu Ser Ser Tyr Gly 
1               5               


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VH CDR 2

<400>  113

Ile Trp Ala Gly Gly Asn Thr 
1               5           


<210>  114
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VH CDR 3

<400>  114

Tyr Phe Gly Ser Arg His Phe Tyr Ser Met Asp Tyr 
1               5                   10          


<210>  115
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 Clone 6E6 Light chain variable

<400>  115

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Met Tyr Phe Cys Gln Asn Gly His Thr Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  116
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VL CDR 1

<400>  116

Gln Gly Ile Ser Asp Tyr 
1               5       


<210>  117
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VL CDR 2

<400>  117

Tyr Ala Ser 
1           


<210>  118
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VL CDR 3

<400>  118

Gln Asn Gly His Thr Phe Pro Leu Thr Phe Gly Ala 
1               5                   10          


<210>  119

<400>  119
000

<210>  120

<400>  120
000

<210>  121
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 Clone 6C10 Heavy chain variable

<400>  121

Glu Ala Leu Leu Gln Gln Ser Gly Pro Asp Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Thr Gly Gly Thr Ile Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Asp Leu His Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Thr Tyr Tyr Gly Asn Ser Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  122
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VH CDR 1

<400>  122

Gly Tyr Thr Phe Thr Asp 
1               5       


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VH CDR 2

<400>  123

Ile Asn Pro Asn Thr Gly Gly Thr 
1               5               


<210>  124
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VH CDR 3

<400>  124

Arg Thr Tyr Tyr Gly Asn Ser Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210>  125
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 Clone 6C10 Light chain variable

<400>  125

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Met Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  126
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VL CDR 1

<400>  126

Gly Asp Ile His Asn 
1               5   


<210>  127
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VL CDR 2

<400>  127

Tyr Asn Ala Lys 
1               


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VL CDR 3

<400>  128

Gln His Phe Trp Ser Phe Pro Trp Thr Phe 
1               5                   10  


<210>  129

<400>  129
000

<210>  130

<400>  130
000

<210>  131
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 Clone 6E6 Heavy chain variable

<400>  131

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Ala Pro Gly Gln 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ala Gly Gly Asn Thr Lys Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Tyr Phe Gly Ser Arg His Phe Tyr Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  132
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VH CDR 1

<400>  132

Gly Phe Ser Leu Ser Ser Tyr Gly 
1               5               


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VH CDR 2

<400>  133

Ile Trp Ala Gly Gly Asn Thr 
1               5           


<210>  134
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VH CDR 3

<400>  134

Tyr Phe Gly Ser Arg His Phe Tyr Ser Met Asp Tyr 
1               5                   10          


<210>  135
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 Clone 6E6 Light chain variable

<400>  135

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser Gly Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Met Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn Gly His Thr Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  136
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VL CDR 1

<400>  136

Gln Gly Ile Ser Asp Tyr 
1               5       


<210>  137
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VL CDR 2

<400>  137

Tyr Ala Ser 
1           


<210>  138
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VL CDR 3

<400>  138

Gln Asn Gly His Thr Phe Pro Leu Thr Phe Gly Ala 
1               5                   10          


<210>  139
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 scFv VH-G4S3-VL

<400>  139

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Ala Pro Gly Gln 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ala Gly Gly Asn Thr Lys Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Tyr Phe Gly Ser Arg His Phe Tyr Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly 
                165                 170                 175     


Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Met Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Asn Gly His Thr Phe Pro Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  140
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 scFv VL-G4S3-VH

<400>  140

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser Gly Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Met Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn Gly His Thr Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Val Val Ala Pro Gly Gln Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Gly Val His Trp Val Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Ala Gly 
                165                 170                 175     


Gly Asn Thr Lys Tyr Asn Ser Ala Leu Met Ser Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Thr Ser Lys Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Glu 
        195                 200                 205             


Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Thr Tyr Phe Gly Ser Arg 
    210                 215                 220                 


His Phe Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  141
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 Clone 6C10 Heavy chain variable

<400>  141

Gln Val Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn 
            20                  25                  30          


Met Asp Trp Val Arg Gln Ser His Gly Gln Ser Leu Glu Trp Met Gly 
        35                  40                  45              


Asp Ile Asn Pro Asn Thr Gly Gly Thr Ile Phe Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Asp Leu His Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Thr Tyr Tyr Gly Asn Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  142
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VH CDR 1

<400>  142

Gly Tyr Thr Phe Thr Asp 
1               5       


<210>  143
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VH CDR 2

<400>  143

Ile Asn Pro Asn Thr Gly Gly Thr 
1               5               


<210>  144
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VH CDR 3

<400>  144

Arg Thr Tyr Tyr Gly Asn Ser Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210>  145
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 Clone 6C10 Light chain variable

<400>  145

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  146
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VL CDR 1

<400>  146

Gly Asp Ile His Asn 
1               5   


<210>  147
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VL CDR 2

<400>  147

Tyr Asn Ala Lys 
1               


<210>  148
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VL CDR 3

<400>  148

Gln His Phe Trp Ser Phe Pro Trp Thr Phe 
1               5                   10  


<210>  149
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 scFv VH-G4S3-VL

<400>  149

Gln Val Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn 
            20                  25                  30          


Met Asp Trp Val Arg Gln Ser His Gly Gln Ser Leu Glu Trp Met Gly 
        35                  40                  45              


Asp Ile Asn Pro Asn Thr Gly Gly Thr Ile Phe Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Asp Leu His Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Thr Tyr Tyr Gly Asn Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gly Asp Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ser Pro Gln Leu Leu Ile Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Thr Leu 
        195                 200                 205             


Thr Ile Asn Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


His Phe Trp Ser Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  150
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 scFv VL-G4S3-VH

<400>  150

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Leu Val Gln Ser 
        115                 120                 125             


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met Asp Trp Val Arg Gln 
145                 150                 155                 160 


Ser His Gly Gln Ser Leu Glu Trp Met Gly Asp Ile Asn Pro Asn Thr 
                165                 170                 175     


Gly Gly Thr Ile Phe Asn Gln Lys Phe Lys Gly Arg Ala Thr Ile Thr 
            180                 185                 190         


Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Asp Leu His Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Thr Tyr Tyr Gly 
    210                 215                 220                 


Asn Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  151
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Asn Gln Ile Glu Pro Gly Val Gln Tyr Asn Tyr Val Tyr Asp Glu 
1               5                   10                  15      


Asp Glu Tyr Met Ile Gln Glu Glu Glu Trp Asp Arg Asp Leu Leu Leu 
            20                  25                  30          


Asp Pro Ala Trp Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys 
        35                  40                  45              


Asn Ser His Leu Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Glu Glu 
    50                  55                  60                  


Asp Phe Arg Asn Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser 
65                  70                  75                  80  


Gly Glu Arg Leu Pro Lys Pro Asp Arg Gly Lys Met Arg Phe His Lys 
                85                  90                  95      


Ile Ala Asn Val Asn Lys Ala Leu Asp Tyr Ile Ala Ser Lys Gly Val 
            100                 105                 110         


Lys Leu Val Ser Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Val Lys 
        115                 120                 125             


Met Thr Leu Gly Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln 
    130                 135                 140                 


Asp Ile Ser Val Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp 
145                 150                 155                 160 


Cys Gln Arg Lys Thr Ala Pro Tyr Arg Asn Val Asn Ile Gln Asn Phe 
                165                 170                 175     


His Thr Ser Trp Lys Asp Gly Leu Gly Leu Cys Ala Leu Ile His Arg 
            180                 185                 190         


His Arg Pro Asp Leu Ile Asp Tyr Ser Lys Leu Asn Lys Asp Asp Pro 
        195                 200                 205             


Ile Gly Asn Ile Asn Leu Ala Met Glu Ile Ala Glu Lys His Leu Asp 
    210                 215                 220                 


Ile Pro Lys Met Leu Asp Ala Glu Asp Ile Val Asn Thr Pro Lys Pro 
225                 230                 235                 240 


Asp Glu Arg Ala Ile Met Thr Tyr Val Ser Cys Phe Tyr His Ala Phe 
                245                 250                 255     


Ala Gly Ala Glu Gln Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val 
            260                 265                 270         


Leu Ala Val Asn Gln Glu Asn Glu Arg Leu Met Glu Glu Tyr Glu Arg 
        275                 280                 285             


Leu Ala Ser Glu Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu 
    290                 295                 300                 


Glu Asn Arg Thr Pro Glu Lys Thr Met Gln Ala Met Gln Lys Lys Leu 
305                 310                 315                 320 


Glu Asp Phe Arg Asp Tyr Arg Arg Lys His Lys Pro Pro Lys Val Gln 
                325                 330                 335     


Glu Lys Cys Gln Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu 
            340                 345                 350         


Arg Ile Ser Asn Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val 
        355                 360                 365             


Ser Asp Ile Ala Gly Ala Trp Gln Arg Leu Glu Gln Ala Glu Lys Gly 
    370                 375                 380                 


Tyr Glu Glu Trp Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Glu 
385                 390                 395                 400 


His Leu Ala Glu Lys Phe Arg Gln Lys Ala Ser Thr His Glu Thr Trp 
                405                 410                 415     


Ala Tyr Gly Lys Glu Gln Ile Leu Leu Gln Lys Asp Tyr Glu Ser Ala 
            420                 425                 430         


Ser Leu Thr Glu Val Arg Ala Leu Leu Arg Lys His Glu Ala Phe Glu 
        435                 440                 445             


Ser Asp Leu Ala Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile 
    450                 455                 460                 


Ala Gln Glu Leu Asn Glu Leu Asp Tyr His Asp Ala Val Asn Val Asn 
465                 470                 475                 480 


Asp Arg Cys Gln Lys Ile Cys Asp Gln Trp Asp Arg Leu Gly Thr Leu 
                485                 490                 495     


Thr Gln Lys Arg Arg Glu Ala Leu Glu Arg Met Glu Lys Leu Leu Glu 
            500                 505                 510         


Thr Ile Asp Gln Leu His Leu Glu Phe Ala Lys Arg Ala Ala Pro Phe 
        515                 520                 525             


Asn Asn Trp Met Glu Gly Ala Met Glu Asp Leu Gln Asp Met Phe Ile 
    530                 535                 540                 


Val His Ser Ile Glu Glu Ile Gln Ser Leu Ile Thr Ala His Glu Gln 
545                 550                 555                 560 


Phe Lys Ala Thr Leu Pro Glu Ala Asp Gly Glu Arg Gln Ser Ile Met 
                565                 570                 575     


Ala Ile Gln Asn Glu Val Glu Lys Val Ile Gln Ser Tyr Asn Ile Arg 
            580                 585                 590         


Ile Ser Ser Ser Asn Pro Tyr Ser Thr Val Thr Met Asp Glu Leu Arg 
        595                 600                 605             


Thr Lys Trp Asp Lys Val Lys Gln Leu Val Pro Ile Arg Asp Gln Ser 
    610                 615                 620                 


Leu Gln Glu Glu Leu Ala Arg Gln His Ala Asn Glu Arg Leu Arg Arg 
625                 630                 635                 640 


Gln Phe Ala Ala Gln Ala Asn Ala Ile Gly Pro Trp Ile Gln Asn Lys 
                645                 650                 655     


Met Glu Glu Ile Ala Arg Ser Ser Ile Gln Ile Thr Gly Ala Leu Glu 
            660                 665                 670         


Asp Gln Met Asn Gln Leu Lys Gln Tyr Glu His Asn Ile Ile Asn Tyr 
        675                 680                 685             


Lys Asn Asn Ile Asp Lys Leu Glu Gly Asp His Gln Leu Ile Gln Glu 
    690                 695                 700                 


Ala Leu Val Phe Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile 
705                 710                 715                 720 


Arg Val Gly Trp Glu Leu Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn 
                725                 730                 735     


Glu Val Glu Thr Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Thr Gln 
            740                 745                 750         


Glu Gln Met Asn Glu Phe Arg Ala Ser Phe Asn His Phe Asp Arg Arg 
        755                 760                 765             


Lys Asn Gly Leu Met Asp His Glu Asp Phe Arg Ala Cys Leu Ile Ser 
    770                 775                 780                 


Met Gly Tyr Asp Leu Gly Glu Ala Glu Phe Ala Arg Ile Met Thr Leu 
785                 790                 795                 800 


Val Asp Pro Asn Gly Gln Gly Thr Val Thr Phe Gln Ser Phe Ile Asp 
                805                 810                 815     


Phe Met Thr Arg Glu Thr Ala Asp Thr Asp Thr Ala Glu Gln Val Ile 
            820                 825                 830         


Ala Ser Phe Arg Ile Leu Ala Ser Asp Lys Pro Tyr Ile Leu Ala Glu 
        835                 840                 845             


Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Gln Tyr Cys Ile Lys 
    850                 855                 860                 


Arg Met Pro Ala Tyr Ser Gly Pro Gly Ser Val Pro Gly Ala Leu Asp 
865                 870                 875                 880 


Tyr Ala Ala Phe Ser Ser Ala Leu Tyr Gly Glu Ser Asp Leu 
                885                 890                 


<210>  152
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala 
            20                  25                  30          


Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
        35                  40                  45              


Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 
    50                  55                  60                  


Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 
65                  70                  75                  80  


Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 
                85                  90                  95      


Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 
            100                 105                 110         


Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 
        115                 120                 125             


Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg 
    130                 135                 140                 


Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val 
145                 150                 155                 160 


Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys 
                165                 170                 175     


Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser 
            180                 185                 190         


Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr 
        195                 200                 205             


Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu 
    210                 215                 220                 


Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys 
225                 230                 235                 240 


Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly 
                245                 250                 255     


Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu 
            260                 265                 270         


Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met 
        275                 280                 285             


Gln Ser Lys 
    290     


<210>  153
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Val Leu Leu Thr Ala Val Leu Leu Leu Leu Ala Ala Tyr Ala Gly 
1               5                   10                  15      


Pro Ala Gln Ser Leu Gly Ser Phe Val His Cys Glu Pro Cys Asp Glu 
            20                  25                  30          


Lys Ala Leu Ser Met Cys Pro Pro Ser Pro Leu Gly Cys Glu Leu Val 
        35                  40                  45              


Lys Glu Pro Gly Cys Gly Cys Cys Met Thr Cys Ala Leu Ala Glu Gly 
    50                  55                  60                  


Gln Ser Cys Gly Val Tyr Thr Glu Arg Cys Ala Gln Gly Leu Arg Cys 
65                  70                  75                  80  


Leu Pro Arg Gln Asp Glu Glu Lys Pro Leu His Ala Leu Leu His Gly 
                85                  90                  95      


Arg Gly Val Cys Leu Asn Glu Lys Ser Tyr Arg Glu Gln Val Lys Ile 
            100                 105                 110         


Glu Arg Asp Ser Arg Glu His Glu Glu Pro Thr Thr Ser Glu Met Ala 
        115                 120                 125             


Glu Glu Thr Tyr Ser Pro Lys Ile Phe Arg Pro Lys His Thr Arg Ile 
    130                 135                 140                 


Ser Glu Leu Lys Ala Glu Ala Val Lys Lys Asp Arg Arg Lys Lys Leu 
145                 150                 155                 160 


Thr Gln Ser Lys Phe Val Gly Gly Ala Glu Asn Thr Ala His Pro Arg 
                165                 170                 175     


Ile Ile Ser Ala Pro Glu Met Arg Gln Glu Ser Glu Gln Gly Pro Cys 
            180                 185                 190         


Arg Arg His Met Glu Ala Ser Leu Gln Glu Leu Lys Ala Ser Pro Arg 
        195                 200                 205             


Met Val Pro Arg Ala Val Tyr Leu Pro Asn Cys Asp Arg Lys Gly Phe 
    210                 215                 220                 


Tyr Lys Arg Lys Gln Cys Lys Pro Ser Arg Gly Arg Lys Arg Gly Ile 
225                 230                 235                 240 


Cys Trp Cys Val Asp Lys Tyr Gly Met Lys Leu Pro Gly Met Glu Tyr 
                245                 250                 255     


Val Asp Gly Asp Phe Gln Cys His Thr Phe Asp Ser Ser Asn Val Glu 
            260                 265                 270         


<210>  154
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Ser Ala Glu Gly Tyr Gln Tyr Arg Ala Leu Tyr Asp Tyr Lys Lys 
1               5                   10                  15      


Glu Arg Glu Glu Asp Ile Asp Leu His Leu Gly Asp Ile Leu Thr Val 
            20                  25                  30          


Asn Lys Gly Ser Leu Val Ala Leu Gly Phe Ser Asp Gly Gln Glu Ala 
        35                  40                  45              


Arg Pro Glu Glu Ile Gly Trp Leu Asn Gly Tyr Asn Glu Thr Thr Gly 
    50                  55                  60                  


Glu Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Tyr Ile Gly Arg Lys 
65                  70                  75                  80  


Lys Ile Ser Pro Pro Thr Pro Lys Pro Arg Pro Pro Arg Pro Leu Pro 
                85                  90                  95      


Val Ala Pro Gly Ser Ser Lys Thr Glu Ala Asp Val Glu Gln Gln Ala 
            100                 105                 110         


Leu Thr Leu Pro Asp Leu Ala Glu Gln Phe Ala Pro Pro Asp Ile Ala 
        115                 120                 125             


Pro Pro Leu Leu Ile Lys Leu Val Glu Ala Ile Glu Lys Lys Gly Leu 
    130                 135                 140                 


Glu Cys Ser Thr Leu Tyr Arg Thr Gln Ser Ser Ser Asn Leu Ala Glu 
145                 150                 155                 160 


Leu Arg Gln Leu Leu Asp Cys Asp Thr Pro Ser Val Asp Leu Glu Met 
                165                 170                 175     


Ile Asp Val His Val Leu Ala Asp Ala Phe Lys Arg Tyr Leu Leu Asp 
            180                 185                 190         


Leu Pro Asn Pro Val Ile Pro Ala Ala Val Tyr Ser Glu Met Ile Ser 
        195                 200                 205             


Leu Ala Pro Glu Val Gln Ser Ser Glu Glu Tyr Ile Gln Leu Leu Lys 
    210                 215                 220                 


Lys Leu Ile Arg Ser Pro Ser Ile Pro His Gln Tyr Trp Leu Thr Leu 
225                 230                 235                 240 


Gln Tyr Leu Leu Lys His Phe Phe Lys Leu Ser Gln Thr Ser Ser Lys 
                245                 250                 255     


Asn Leu Leu Asn Ala Arg Val Leu Ser Glu Ile Phe Ser Pro Met Leu 
            260                 265                 270         


Phe Arg Phe Ser Ala Ala Ser Ser Asp Asn Thr Glu Asn Leu Ile Lys 
        275                 280                 285             


Val Ile Glu Ile Leu Ile Ser Thr Glu Trp Asn Glu Arg Gln Pro Ala 
    290                 295                 300                 


Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Thr Thr Val Ala Asn Asn 
305                 310                 315                 320 


Gly Met Asn Asn Asn Met Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly 
                325                 330                 335     


Asp Ile Ser Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Ala Asp 
            340                 345                 350         


Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met His Gly Asp Tyr 
        355                 360                 365             


Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Phe 
    370                 375                 380                 


His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Ser Ser 
385                 390                 395                 400 


Val Val Glu Leu Ile Asn His Tyr Arg Asn Glu Ser Leu Ala Gln Tyr 
                405                 410                 415     


Asn Pro Lys Leu Asp Val Lys Leu Leu Tyr Pro Val Ser Lys Tyr Gln 
            420                 425                 430         


Gln Asp Gln Val Val Lys Glu Asp Asn Ile Glu Ala Val Gly Lys Lys 
        435                 440                 445             


Leu His Glu Tyr Asn Thr Gln Phe Gln Glu Lys Ser Arg Glu Tyr Asp 
    450                 455                 460                 


Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln Met Lys 
465                 470                 475                 480 


Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu 
                485                 490                 495     


Gln Cys Gln Thr Gln Glu Arg Tyr Ser Lys Glu Tyr Ile Glu Lys Phe 
            500                 505                 510         


Lys Arg Glu Gly Asn Glu Lys Glu Ile Gln Arg Ile Met His Asn Tyr 
        515                 520                 525             


Asp Lys Leu Lys Ser Arg Ile Ser Glu Ile Ile Asp Ser Arg Arg Arg 
    530                 535                 540                 


Leu Glu Glu Asp Leu Lys Lys Gln Ala Ala Glu Tyr Arg Glu Ile Asp 
545                 550                 555                 560 


Lys Arg Met Asn Ser Ile Lys Pro Asp Leu Ile Gln Leu Arg Lys Thr 
                565                 570                 575     


Arg Asp Gln Tyr Leu Met Trp Leu Thr Gln Lys Gly Val Arg Gln Lys 
            580                 585                 590         


Lys Leu Asn Glu Trp Leu Gly Asn Glu Asn Thr Glu Asp Gln Tyr Ser 
        595                 600                 605             


Leu Val Glu Asp Asp Glu Asp Leu Pro His His Asp Glu Lys Thr Trp 
    610                 615                 620                 


Asn Val Gly Ser Ser Asn Arg Asn Lys Ala Glu Asn Leu Leu Arg Gly 
625                 630                 635                 640 


Lys Arg Asp Gly Thr Phe Leu Val Arg Glu Ser Ser Lys Gln Gly Cys 
                645                 650                 655     


Tyr Ala Cys Ser Val Val Val Asp Gly Glu Val Lys His Cys Val Ile 
            660                 665                 670         


Asn Lys Thr Ala Thr Gly Tyr Gly Phe Ala Glu Pro Tyr Asn Leu Tyr 
        675                 680                 685             


Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln His Thr Ser Leu Val 
    690                 695                 700                 


Gln His Asn Asp Ser Leu Asn Val Thr Leu Ala Tyr Pro Val Tyr Ala 
705                 710                 715                 720 


Gln Gln Arg Arg 
                


<210>  155
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
1               5                   10                  15      


Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
            20                  25                  30          


Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
        35                  40                  45              


Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
    50                  55                  60                  


Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
65                  70                  75                  80  


Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                85                  90                  95      


Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
            100                 105                 110         


Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
        115                 120                 125             


Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
    130                 135                 140                 


Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
145                 150                 155                 160 


Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                165                 170                 175     


Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
            180                 185                 190         


Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
        195                 200                 205             


<210>  156
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  156

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                  25                  30          


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
        35                  40                  45              


Trp Trp Glu Leu Arg 
    50              


<210>  157
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Asp Arg Ala Ala Arg Cys Ser Gly Ala Ser Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Leu Ala Leu Gly Leu Val Ile Leu His Cys Val Val Ala Asp 
            20                  25                  30          


Gly Asn Ser Thr Arg Ser Pro Glu Thr Asn Gly Leu Leu Cys Gly Asp 
        35                  40                  45              


Pro Glu Glu Asn Cys Ala Ala Thr Thr Thr Gln Ser Lys Arg Lys Gly 
    50                  55                  60                  


His Phe Ser Arg Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys Gly 
65                  70                  75                  80  


Arg Cys Arg Phe Val Val Ala Glu Gln Thr Pro Ser Cys Val Cys Asp 
                85                  90                  95      


Glu Gly Tyr Ile Gly Ala Arg Cys Glu Arg Val Asp Leu Phe Tyr Leu 
            100                 105                 110         


Arg Gly Asp Arg Gly Gln Ile Leu Val Ile Cys Met Ile Ala Val Met 
        115                 120                 125             


Val Val Phe Ile Ile Leu Val Ile Gly Val Cys Thr Cys Cys His Pro 
    130                 135                 140                 


Leu Arg Lys Arg Arg Lys Arg Lys Lys Lys Glu Glu Glu Met Glu Thr 
145                 150                 155                 160 


Leu Gly Lys Asp Ile Thr Pro Ile Asn Glu Asp Ile Glu Glu Thr Asn 
                165                 170                 175     


Ile Ala 
        


<210>  158
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro 
                325                 330                 335     


Cys Lys Asn Gly Gly Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys 
            340                 345                 350         


Thr Cys Pro Pro Gly Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met 
        355                 360                 365             


Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser 
    370                 375                 380                 


Pro Asp Gly Gly Tyr Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn 
                405                 410                 415     


Gly Ala Lys Cys Val Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln 
            420                 425                 430         


Ala Gly Phe Ser Gly Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala 
        435                 440                 445             


Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp 
    450                 455                 460                 


Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala 
465                 470                 475                 480 


Pro Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys 
                485                 490                 495     


His Glu Arg Gly His Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly 
            500                 505                 510         


Gly Pro Asn Cys Gln Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala 
        515                 520                 525             


Val Val Asp Leu Thr Glu Lys Leu Glu Gly Gln Gly Gly Pro Phe Pro 
    530                 535                 540                 


Trp Val Ala Val Cys Ala Gly Val Ile Leu Val Leu Met Leu Leu Leu 
545                 550                 555                 560 


Gly Cys Ala Ala Val Val Val Cys Val Arg Leu Arg Leu Gln Lys His 
                565                 570                 575     


Arg Pro Pro Ala Asp Pro Cys Arg Gly Glu Thr Glu Thr Met Asn Asn 
            580                 585                 590         


Leu Ala Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Ile Ile Gly 
        595                 600                 605             


Ala Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp 
    610                 615                 620                 


His Ser Ala Asp Lys Asn Gly Phe Lys Ala Arg Tyr Pro Ala Val Asp 
625                 630                 635                 640 


Tyr Asn Leu Val Gln Asp Leu Lys Gly Asp Asp Thr Ala Val Arg Asp 
                645                 650                 655     


Ala His Ser Lys Arg Asp Thr Lys Cys Gln Pro Gln Gly Ser Ser Gly 
            660                 665                 670         


Glu Glu Lys Gly Thr Pro Thr Thr Leu Arg Gly Gly Glu Ala Ser Glu 
        675                 680                 685             


Arg Lys Arg Pro Asp Ser Gly Cys Ser Thr Ser Lys Asp Thr Lys Tyr 
    690                 695                 700                 


Gln Ser Val Tyr Val Ile Ser Glu Glu Lys Asp Glu Cys Val Ile Ala 
705                 710                 715                 720 


Thr Glu Val 
            


<210>  159
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Glu Pro Phe Thr Asn Asp Arg Leu Gln Leu Pro Arg Asn Met Ile 
1               5                   10                  15      


Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys 
            20                  25                  30          


Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro 
        35                  40                  45              


Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu 
    50                  55                  60                  


Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser 
65                  70                  75                  80  


Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg 
                85                  90                  95      


Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val 
            100                 105                 110         


Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile 
        115                 120                 125             


Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys 
    130                 135                 140                 


Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu 
145                 150                 155                 160 


Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg 
                165                 170                 175     


Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly 
            180                 185                 190         


Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile 
        195                 200                 205             


Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala 
    210                 215                 220                 


Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His 
225                 230                 235                 240 


Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn 
                245                 250                 255     


Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr 
            260                 265                 270         


Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr 
        275                 280                 285             


Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro 
    290                 295                 300                 


Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile 
305                 310                 315                 320 


Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser 
                325                 330                 335     


Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val 
            340                 345                 350         


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn 
        355                 360                 365             


Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro 
    370                 375                 380                 


Glu Lys Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu 
385                 390                 395                 400 


Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys 
                405                 410                 415     


Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn 
            420                 425                 430         


Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn 
        435                 440                 445             


Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His 
    450                 455                 460                 


Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp 
465                 470                 475                 480 


Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe 
                485                 490                 495     


Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu 
            500                 505                 510         


Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His 
        515                 520                 525             


Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe 
    530                 535                 540                 


Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys 
545                 550                 555                 560 


Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu 
                565                 570                 575     


His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser 
            580                 585                 590         


Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys 
        595                 600                 605             


Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys 
    610                 615                 620                 


Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys 
625                 630                 635                 640 


Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu 
                645                 650                 655     


Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser 
            660                 665                 670         


Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu 
        675                 680                 685             


Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr 
    690                 695                 700                 


Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro 
705                 710                 715                 720 


Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe 
                725                 730                 735     


Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu 
            740                 745                 750         


Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala 
        755                 760                 765             


Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr 
    770                 775                 780                 


Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln 
785                 790                 795                 800 


Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met 
                805                 810                 815     


Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu 
            820                 825                 830         


Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala 
        835                 840                 845             


Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe 
    850                 855                 860                 


Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys 
865                 870                 875                 880 


Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala 
                885                 890                 895     


Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser 
            900                 905                 910         


Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile 
        915                 920                 925             


Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe 
    930                 935                 940                 


Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser 
945                 950                 955                 960 


Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr 
                965                 970                 975     


Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu 
            980                 985                 990         


Ala Thr Phe Arg Leu Arg Cys Val  Gln Glu Ala Leu Glu  Val Ile Gln 
        995                 1000                 1005             


Leu Asn  Ile Gln Trp Met Glu  Lys Asn Leu Lys Ser  Leu Thr Trp 
    1010                 1015                 1020             


Trp Leu  
    1025 


<210>  160
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lead sequence

<400>  160

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  161
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD28 transmembrane domain

<400>  161

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  162
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD3 zeta intracellular signaling domain

<400>  162

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  163
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD28 hinge

<400>  163

Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
1               5                   10                  15      


Pro Ser Lys Pro 
            20  


<210>  164
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD28 costimulatory domain

<400>  164

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Leu 
        35                  40              


<210>  165
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human 4-1BB costimulatory domain

<400>  165

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  166
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human DAP10 costimulatory domain

<400>  166

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210>  167
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glycine-Serine linker unite

<400>  167

Gly Gly Gly Gly Ser 
1               5   


<210>  168
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly-Gly-Gly-Gly-Ser)X3 linker ((Gly4Ser)3 linker, (G4S)3 linker,
       G4S X3 linker, or G4SX3 linker)

<400>  168

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  169
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A ribosomal skip sequence

<400>  169

Ala Gly Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
1               5                   10                  15      


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg 
            20                  25              


<210>  170
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated CD19

<400>  170

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr 
                325         


<210>  171
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h6E6scFvHL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  171

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Ala Pro Gly Gln 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ala Gly Gly Asn Thr Lys Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Tyr Phe Gly Ser Arg His Phe Tyr Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly 
                165                 170                 175     


Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Met Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Asn Gly His Thr Phe Pro Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu 
225                 230                 235                 240 


Ile Lys Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
    290                 295                 300                 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
305                 310                 315                 320 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Leu Arg Val Lys Phe 
                325                 330                 335     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            340                 345                 350         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        355                 360                 365             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
    370                 375                 380                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
385                 390                 395                 400 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                405                 410                 415     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            420                 425                 430         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445 


<210>  172
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h6E6scFvHL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  172

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Ala Pro Gly Gln 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ala Gly Gly Asn Thr Lys Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Tyr Phe Gly Ser Arg His Phe Tyr Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly 
                165                 170                 175     


Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Met Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Asn Gly His Thr Phe Pro Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu 
225                 230                 235                 240 


Ile Lys Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    290                 295                 300                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
305                 310                 315                 320 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                325                 330                 335     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            340                 345                 350         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        355                 360                 365             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
    370                 375                 380                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
385                 390                 395                 400 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                405                 410                 415     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            420                 425                 430         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 


<210>  173
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h6E6scFvHL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  173

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Ala Pro Gly Gln 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ala Gly Gly Asn Thr Lys Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Tyr Phe Gly Ser Arg His Phe Tyr Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly 
                165                 170                 175     


Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Met Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Asn Gly His Thr Phe Pro Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu 
225                 230                 235                 240 


Ile Lys Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys 
    290                 295                 300                 


Val Tyr Ile Asn Met Pro Gly Arg Gly Arg Val Lys Phe Ser Arg Ser 
305                 310                 315                 320 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                325                 330                 335     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            340                 345                 350         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
        355                 360                 365             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    370                 375                 380                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
385                 390                 395                 400 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                405                 410                 415     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425     


<210>  174
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h6E6scFvLH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  174

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser Gly Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Met Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn Gly His Thr Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Val Val Ala Pro Gly Gln Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Gly Val His Trp Val Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Ala Gly 
                165                 170                 175     


Gly Asn Thr Lys Tyr Asn Ser Ala Leu Met Ser Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Thr Ser Lys Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Glu 
        195                 200                 205             


Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Thr Tyr Phe Gly Ser Arg 
    210                 215                 220                 


His Phe Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
    290                 295                 300                 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
305                 310                 315                 320 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Leu Arg Val Lys Phe 
                325                 330                 335     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            340                 345                 350         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        355                 360                 365             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
    370                 375                 380                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
385                 390                 395                 400 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                405                 410                 415     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            420                 425                 430         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445 


<210>  175
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h6E6scFvLH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  175

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser Gly Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Met Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn Gly His Thr Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Val Val Ala Pro Gly Gln Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Gly Val His Trp Val Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Ala Gly 
                165                 170                 175     


Gly Asn Thr Lys Tyr Asn Ser Ala Leu Met Ser Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Thr Ser Lys Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Glu 
        195                 200                 205             


Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Thr Tyr Phe Gly Ser Arg 
    210                 215                 220                 


His Phe Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    290                 295                 300                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
305                 310                 315                 320 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                325                 330                 335     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            340                 345                 350         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        355                 360                 365             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
    370                 375                 380                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
385                 390                 395                 400 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                405                 410                 415     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            420                 425                 430         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 


<210>  176
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h6E6scFvLH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  176

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser Gly Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Met Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn Gly His Thr Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Val Val Ala Pro Gly Gln Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Gly Val His Trp Val Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Ala Gly 
                165                 170                 175     


Gly Asn Thr Lys Tyr Asn Ser Ala Leu Met Ser Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Thr Ser Lys Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Glu 
        195                 200                 205             


Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Thr Tyr Phe Gly Ser Arg 
    210                 215                 220                 


His Phe Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys 
    290                 295                 300                 


Val Tyr Ile Asn Met Pro Gly Arg Gly Arg Val Lys Phe Ser Arg Ser 
305                 310                 315                 320 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                325                 330                 335     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            340                 345                 350         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
        355                 360                 365             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    370                 375                 380                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
385                 390                 395                 400 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                405                 410                 415     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425     


<210>  177
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h6C10scFvHL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  177

Gln Val Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn 
            20                  25                  30          


Met Asp Trp Val Arg Gln Ser His Gly Gln Ser Leu Glu Trp Met Gly 
        35                  40                  45              


Asp Ile Asn Pro Asn Thr Gly Gly Thr Ile Phe Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Asp Leu His Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Thr Tyr Tyr Gly Asn Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gly Asp Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ser Pro Gln Leu Leu Ile Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Thr Leu 
        195                 200                 205             


Thr Ile Asn Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


His Phe Trp Ser Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
    290                 295                 300                 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
305                 310                 315                 320 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Leu Arg Val Lys Phe 
                325                 330                 335     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            340                 345                 350         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        355                 360                 365             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
    370                 375                 380                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
385                 390                 395                 400 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                405                 410                 415     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            420                 425                 430         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445 


<210>  178
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h6C10scFvHL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  178

Gln Val Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn 
            20                  25                  30          


Met Asp Trp Val Arg Gln Ser His Gly Gln Ser Leu Glu Trp Met Gly 
        35                  40                  45              


Asp Ile Asn Pro Asn Thr Gly Gly Thr Ile Phe Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Asp Leu His Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Thr Tyr Tyr Gly Asn Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gly Asp Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ser Pro Gln Leu Leu Ile Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Thr Leu 
        195                 200                 205             


Thr Ile Asn Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


His Phe Trp Ser Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    290                 295                 300                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
305                 310                 315                 320 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                325                 330                 335     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            340                 345                 350         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        355                 360                 365             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
    370                 375                 380                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
385                 390                 395                 400 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                405                 410                 415     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            420                 425                 430         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 


<210>  179
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h6C10scFvHL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  179

Gln Val Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn 
            20                  25                  30          


Met Asp Trp Val Arg Gln Ser His Gly Gln Ser Leu Glu Trp Met Gly 
        35                  40                  45              


Asp Ile Asn Pro Asn Thr Gly Gly Thr Ile Phe Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Asp Leu His Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Thr Tyr Tyr Gly Asn Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gly Asp Ile His Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ser Pro Gln Leu Leu Ile Tyr Asn Ala Lys Thr Leu Ala Asp Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Thr Leu 
        195                 200                 205             


Thr Ile Asn Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


His Phe Trp Ser Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys 
    290                 295                 300                 


Val Tyr Ile Asn Met Pro Gly Arg Gly Arg Val Lys Phe Ser Arg Ser 
305                 310                 315                 320 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                325                 330                 335     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            340                 345                 350         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
        355                 360                 365             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    370                 375                 380                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
385                 390                 395                 400 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                405                 410                 415     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425     


<210>  180
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h6C10scFvLH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  180

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Leu Val Gln Ser 
        115                 120                 125             


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met Asp Trp Val Arg Gln 
145                 150                 155                 160 


Ser His Gly Gln Ser Leu Glu Trp Met Gly Asp Ile Asn Pro Asn Thr 
                165                 170                 175     


Gly Gly Thr Ile Phe Asn Gln Lys Phe Lys Gly Arg Ala Thr Ile Thr 
            180                 185                 190         


Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Asp Leu His Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Thr Tyr Tyr Gly 
    210                 215                 220                 


Asn Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
    290                 295                 300                 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
305                 310                 315                 320 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Leu Arg Val Lys Phe 
                325                 330                 335     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            340                 345                 350         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        355                 360                 365             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
    370                 375                 380                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
385                 390                 395                 400 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                405                 410                 415     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            420                 425                 430         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445 


<210>  181
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h6C10scFvLH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  181

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Leu Val Gln Ser 
        115                 120                 125             


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met Asp Trp Val Arg Gln 
145                 150                 155                 160 


Ser His Gly Gln Ser Leu Glu Trp Met Gly Asp Ile Asn Pro Asn Thr 
                165                 170                 175     


Gly Gly Thr Ile Phe Asn Gln Lys Phe Lys Gly Arg Ala Thr Ile Thr 
            180                 185                 190         


Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Asp Leu His Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Thr Tyr Tyr Gly 
    210                 215                 220                 


Asn Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    290                 295                 300                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
305                 310                 315                 320 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                325                 330                 335     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            340                 345                 350         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        355                 360                 365             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
    370                 375                 380                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
385                 390                 395                 400 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                405                 410                 415     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            420                 425                 430         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 


<210>  182
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6C10scFvLH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  182

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Leu Val Gln Ser 
        115                 120                 125             


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met Asp Trp Val Arg Gln 
145                 150                 155                 160 


Ser His Gly Gln Ser Leu Glu Trp Met Gly Asp Ile Asn Pro Asn Thr 
                165                 170                 175     


Gly Gly Thr Ile Phe Asn Gln Lys Phe Lys Gly Arg Ala Thr Ile Thr 
            180                 185                 190         


Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Asp Leu His Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Thr Tyr Tyr Gly 
    210                 215                 220                 


Asn Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Leu Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                245                 250                 255     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            260                 265                 270         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        275                 280                 285             


Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys 
    290                 295                 300                 


Val Tyr Ile Asn Met Pro Gly Arg Gly Arg Val Lys Phe Ser Arg Ser 
305                 310                 315                 320 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                325                 330                 335     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            340                 345                 350         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
        355                 360                 365             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    370                 375                 380                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
385                 390                 395                 400 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                405                 410                 415     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425     


<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190

<400>  190
000

<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194
<211>  820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-h6E6scFvLH-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  194

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Glu Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Met Ser Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn Gly His 
            100                 105                 110         


Thr Phe Pro Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Ala Pro Gly Gln Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Gly Val 
                165                 170                 175     


His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val Ala Val 
            180                 185                 190         


Ile Trp Ala Gly Gly Asn Thr Lys Tyr Asn Ser Ala Leu Met Ser Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Thr Ser Lys Thr Thr Val Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Glu Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Thr Tyr 
225                 230                 235                 240 


Phe Gly Ser Arg His Phe Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Leu Glu Val Lys Gly Lys His Leu Cys Pro 
            260                 265                 270         


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        275                 280                 285             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    290                 295                 300                 


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
305                 310                 315                 320 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                325                 330                 335     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg Ala Gly Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Pro Pro 
                485                 490                 495     


Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg 
            500                 505                 510         


Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val 
        515                 520                 525             


Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr 
    530                 535                 540                 


Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly 
545                 550                 555                 560 


Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe 
                565                 570                 575     


Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro 
            580                 585                 590         


Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val 
        595                 600                 605             


Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly 
    610                 615                 620                 


Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro 
625                 630                 635                 640 


Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg 
                645                 650                 655     


Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser 
            660                 665                 670         


Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr 
        675                 680                 685             


Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro 
    690                 695                 700                 


Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser 
705                 710                 715                 720 


Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu 
                725                 730                 735     


Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr 
            740                 745                 750         


Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr 
        755                 760                 765             


Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys 
    770                 775                 780                 


Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu 
785                 790                 795                 800 


Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg 
                805                 810                 815     


Lys Arg Met Thr 
            820 


<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197
<211>  820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-h6C10scFvHL-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  197

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ser His Gly Gln Ser Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Asn Pro Asn Thr Gly Gly Thr Ile Phe Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Ile Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Asp Leu His Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Thr Tyr Tyr Gly Asn Ser Tyr Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gly Asp Ile His Asn Tyr Leu Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr Asn Ala Lys Thr 
        195                 200                 205             


Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Gln Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln His Phe Trp Ser Phe Pro Trp Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Leu Glu Val Lys Gly Lys His Leu Cys Pro 
            260                 265                 270         


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        275                 280                 285             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    290                 295                 300                 


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
305                 310                 315                 320 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                325                 330                 335     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg Ala Gly Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Pro Pro 
                485                 490                 495     


Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg 
            500                 505                 510         


Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val 
        515                 520                 525             


Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr 
    530                 535                 540                 


Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly 
545                 550                 555                 560 


Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe 
                565                 570                 575     


Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro 
            580                 585                 590         


Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val 
        595                 600                 605             


Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly 
    610                 615                 620                 


Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro 
625                 630                 635                 640 


Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg 
                645                 650                 655     


Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser 
            660                 665                 670         


Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr 
        675                 680                 685             


Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro 
    690                 695                 700                 


Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser 
705                 710                 715                 720 


Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu 
                725                 730                 735     


Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr 
            740                 745                 750         


Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr 
        755                 760                 765             


Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys 
    770                 775                 780                 


Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu 
785                 790                 795                 800 


Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg 
                805                 810                 815     


Lys Arg Met Thr 
            820 


<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200

<400>  200
000

<210>  201

<400>  201
000

<210>  202

<400>  202
000

<210>  203

<400>  203
000

<210>  204

<400>  204
000

<210>  205

<400>  205
000

<210>  206

<400>  206
000

<210>  207

<400>  207
000

<210>  208

<400>  208
000

<210>  209

<400>  209
000

<210>  210

<400>  210
000

<210>  211
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 Clone 6E6 Heavy chain variable

<400>  211
caggtgcagc tgcaggagtc tggacccggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaagc tcctatggag tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta atatgggctg gtggaaacac aaaatataat      180

tcggctctca tgtccagact gagcatcagc agagacacct ccaagaccca agtcttctta      240

gaaatgaata gtctggaaac tgatgacaca gccatgtact actgtgccac ttacttcggt      300

agccgacact tctattctat ggactattgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  212
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VH CDR 1

<400>  212
gggttttcat taagctccta tgga                                              24


<210>  213
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VH CDR 2

<400>  213
atatgggctg gtggaaacac a                                                 21


<210>  214
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VH CDR 3

<400>  214
tacttcggta gccgacactt ctattctatg gactat                                 36


<210>  215
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 Clone 6E6 Light chain variable

<400>  215
gacattgtga tgactcagtc tccagccacc ctgtctgtga ctccaggaga tagagtctct       60

ctttcctgca gggccagcca gggtattagc gactacttac actggtatca acaaaaatca      120

catgagtctc cgaggcttct catcaaatat gcttcccaat ccatgtctgg gatcccctcc      180

aggttcagtg gcagtggatc agggtcagat ttcactctca ctatcaacag tgtggaacct      240

gaagatgttg gaatgtattt ctgtcaaaat ggtcacacct ttccgctcac gttcggtgct      300

gggaccaagc tggaaataaa ac                                               322


<210>  216
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VL CDR 1

<400>  216
cagggtatta gcgactac                                                     18


<210>  217
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VL CDR 2

<400>  217
tatgcttcc                                                                9


<210>  218
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6E6 VL CDR 3

<400>  218
caaaatggtc acacctttcc gctcacgttc ggtgctg                                37


<210>  219

<400>  219
000

<210>  220

<400>  220
000

<210>  221
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 Clone 6C10 Heavy chain variable

<400>  221
gaggccctgc tgcagcagtc tggacctgat ctggcgaagc ctggggcttc agtacaaata       60

ccctgcaagg cttctggata cacattcact gattacaaca tggactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaatccaa acactggtgg tacaatcttc      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagccttc      240

atggacctcc acagcctgac atctgaggac actgcagtct attactgtgc aagacggacc      300

tactatggaa acagctacta ctttgactac tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  222
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VH CDR 1

<400>  222
ggatacacat tcactgat                                                     18


<210>  223
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VH CDR 2

<400>  223
attaatccaa acactggtgg taca                                              24


<210>  224
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VH CDR 3

<400>  224
cggacctact atggaaacag ctactacttt gactac                                 36


<210>  225
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 Clone 6C10 Light chain variable

<400>  225
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtgg ggatattcac aattatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggaacacaa tattctctca agatgaacag cctgcagcct      240

gaagattttg ggacttatta ctgtcaacat ttttggagtt ttccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  226
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VL CDR 1

<400>  226
ggggatattc acaat                                                        15


<210>  227
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VL CDR 2

<400>  227
tataatgcaa aa                                                           12


<210>  228
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse anti-ADAM12 6C10 VL CDR 3

<400>  228
caacattttt ggagttttcc gtggacgttc                                        30


<210>  229

<400>  229
000

<210>  230

<400>  230
000

<210>  231
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 Clone 6E6 Heavy chain variable

<400>  231
caggtgcagc tggtggagag cggaggaggt gtagttgctc ctggacagag cctgagactg       60

agctgtaccg ccagcgggtt cagcctgagc agctacgggg tgcactgggt gagacagccc      120

cccgggaagg ggctggagtg ggtggccgtg atctgggccg gggggaacac caagtacaac      180

agcgccctga tgagcagatt caccatcagc agagatacca gcaagaccac cgtgtacctg      240

cagatgaaca gcctggagac cgaggatacc gccatgtact actgtgccac ctacttcggg      300

agcagacact tctacagcat ggattactgg gggcagggga ccctggtgac cgtgagcagc      360


<210>  232
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VH CDR 1

<400>  232
gggttcagcc tgagcagcta cggg                                              24


<210>  233
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VH CDR 2

<400>  233
atctgggccg gggggaacac c                                                 21


<210>  234
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VH CDR 3

<400>  234
tacttcggga gcagacactt ctacagcatg gattac                                 36


<210>  235
<211>  321
<212>  DNA
<213>  Humanized anti-ADAM12 Clone 6E6 Light chain variable

<400>  235
gatatcgtgc tgacccagag ccccgccacc ctgagcgtga gccccgggga gagagccacc       60

ctgagctgta gagccagcca ggggatcagc gattacctgc actggtacca gcagaagagc      120

ggggagagcc ccagactgct gatcaagtac gccagccaga gcatgagcgg gatccccgcc      180

agattcagcg ggagcgggag cgggaccgat ttcaccctga ccatcagcag cctggagccc      240

gaggatgtgg ccgtgtacta ctgtcagaac gggcacacct tccccctgac cttcggggcc      300

gggaccagac tggagatcaa g                                                321


<210>  236
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VL CDR 1

<400>  236
caggggatca gcgattac                                                     18


<210>  237
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VL CDR 2

<400>  237
tacgccagc                                                                9


<210>  238
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 VL CDR 3

<400>  238
cagaacgggc acaccttccc cctgaccttc ggggcc                                 36


<210>  239
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 scFv VH-G4S3-VL

<400>  239
caggtgcagc tggtggagag cggaggaggt gtagttgctc ctggacagag cctgagactg       60

agctgtaccg ccagcgggtt cagcctgagc agctacgggg tgcactgggt gagacagccc      120

cccgggaagg ggctggagtg ggtggccgtg atctgggccg gggggaacac caagtacaac      180

agcgccctga tgagcagatt caccatcagc agagatacca gcaagaccac cgtgtacctg      240

cagatgaaca gcctggagac cgaggatacc gccatgtact actgtgccac ctacttcggg      300

agcagacact tctacagcat ggattactgg gggcagggga ccctggtgac cgtgagcagc      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgatat cgtgctgacc      420

cagagccccg ccaccctgag cgtgagcccc ggggagagag ccaccctgag ctgtagagcc      480

agccagggga tcagcgatta cctgcactgg taccagcaga agagcgggga gagccccaga      540

ctgctgatca agtacgccag ccagagcatg agcgggatcc ccgccagatt cagcgggagc      600

gggagcggga ccgatttcac cctgaccatc agcagcctgg agcccgagga tgtggccgtg      660

tactactgtc agaacgggca caccttcccc ctgaccttcg gggccgggac cagactggag      720

atcaag                                                                 726


<210>  240
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6E6 scFv VL-G4S3-VH

<400>  240
gatatcgtgc tgacccagag ccccgccacc ctgagcgtga gccccgggga gagagccacc       60

ctgagctgta gagccagcca ggggatcagc gattacctgc actggtacca gcagaagagc      120

ggggagagcc ccagactgct gatcaagtac gccagccaga gcatgagcgg gatccccgcc      180

agattcagcg ggagcgggag cgggaccgat ttcaccctga ccatcagcag cctggagccc      240

gaggatgtgg ccgtgtacta ctgtcagaac gggcacacct tccccctgac cttcggggcc      300

gggaccagac tggagatcaa gggtggtggt ggttctggcg gcggcggctc cggtggtggt      360

ggttcccagg tgcagctggt ggagagcgga ggaggtgtag ttgctcctgg acagagcctg      420

agactgagct gtaccgccag cgggttcagc ctgagcagct acggggtgca ctgggtgaga      480

cagccccccg ggaaggggct ggagtgggtg gccgtgatct gggccggggg gaacaccaag      540

tacaacagcg ccctgatgag cagattcacc atcagcagag ataccagcaa gaccaccgtg      600

tacctgcaga tgaacagcct ggagaccgag gataccgcca tgtactactg tgccacctac      660

ttcgggagca gacacttcta cagcatggat tactgggggc aggggaccct ggtgaccgtg      720

agcagc                                                                 726


<210>  241
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 Clone 6C10 Heavy chain variable

<400>  241
caggtgctgg tgcagagcgg ggccgaggtg aagaagcccg gggccagcgt gaaggtgagc       60

tgtaaggcca gcgggtacac cttcaccgat tacaacatgg attgggtgag acagagccac      120

gggcagagcc tggagtggat gggggatatc aaccccaaca ccggggggac catcttcaac      180

cagaagttca aggggagagc caccatcacc gtggatacca gcagcagcac cgcctacatg      240

gatctgcaca gcctgaccag cgaggatacc gccgtgtact actgtgccag aagaacctac      300

tacgggaaca gctactactt cgattactgg gggcagggga ccctggtgac cgtgagcagc      360


<210>  242
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VH CDR 1

<400>  242
gggtacacct tcaccgat                                                     18


<210>  243
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VH CDR 2

<400>  243
atcaacccca acaccggggg gacc                                              24


<210>  244
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VH CDR 3

<400>  244
agaacctact acgggaacag ctactacttc gattac                                 36


<210>  245
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 Clone 6C10 Light chain variable

<400>  245
gatatccaga tgacccagag ccccgccagc ctgagcgcca gcgtggggga gagagtgacc       60

atcacctgta gagccagcgg ggatatccac aactacctgg cctggtacca gcagaagccc      120

gggaagagcc cccagctgct gatctacaac gccaagaccc tggccgatgg ggtgcccagc      180

agattcagcg ggagcgggag cgggacccag tacaccctga ccatcaacag cctgcagccc      240

gaggatttcg ccacctacta ctgtcagcac ttctggagct tcccctggac cttcgggggg      300

gggaccaagc tggagatcaa g                                                321


<210>  246
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VL CDR 1

<400>  246
ggggatatcc acaac                                                        15


<210>  247
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VL CDR 2

<400>  247
tacaacgcca ag                                                           12


<210>  248
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 VL CDR 3

<400>  248
cagcacttct ggagcttccc ctggaccttc                                        30


<210>  249
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 scFv VH-G4S3-VL

<400>  249
caggtgctgg tgcagagcgg ggccgaggtg aagaagcccg gggccagcgt gaaggtgagc       60

tgtaaggcca gcgggtacac cttcaccgat tacaacatgg attgggtgag acagagccac      120

gggcagagcc tggagtggat gggggatatc aaccccaaca ccggggggac catcttcaac      180

cagaagttca aggggagagc caccatcacc gtggatacca gcagcagcac cgcctacatg      240

gatctgcaca gcctgaccag cgaggatacc gccgtgtact actgtgccag aagaacctac      300

tacgggaaca gctactactt cgattactgg gggcagggga ccctggtgac cgtgagcagc      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgatat ccagatgacc      420

cagagccccg ccagcctgag cgccagcgtg ggggagagag tgaccatcac ctgtagagcc      480

agcggggata tccacaacta cctggcctgg taccagcaga agcccgggaa gagcccccag      540

ctgctgatct acaacgccaa gaccctggcc gatggggtgc ccagcagatt cagcgggagc      600

gggagcggga cccagtacac cctgaccatc aacagcctgc agcccgagga tttcgccacc      660

tactactgtc agcacttctg gagcttcccc tggaccttcg ggggggggac caagctggag      720

atcaag                                                                 726


<210>  250
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-ADAM12 6C10 scFv VL-G4S3-VH

<400>  250
gatatccaga tgacccagag ccccgccagc ctgagcgcca gcgtggggga gagagtgacc       60

atcacctgta gagccagcgg ggatatccac aactacctgg cctggtacca gcagaagccc      120

gggaagagcc cccagctgct gatctacaac gccaagaccc tggccgatgg ggtgcccagc      180

agattcagcg ggagcgggag cgggacccag tacaccctga ccatcaacag cctgcagccc      240

gaggatttcg ccacctacta ctgtcagcac ttctggagct tcccctggac cttcgggggg      300

gggaccaagc tggagatcaa gggtggtggt ggttctggcg gcggcggctc cggtggtggt      360

ggttcccagg tgctggtgca gagcggggcc gaggtgaaga agcccggggc cagcgtgaag      420

gtgagctgta aggccagcgg gtacaccttc accgattaca acatggattg ggtgagacag      480

agccacgggc agagcctgga gtggatgggg gatatcaacc ccaacaccgg ggggaccatc      540

ttcaaccaga agttcaaggg gagagccacc atcaccgtgg ataccagcag cagcaccgcc      600

tacatggatc tgcacagcct gaccagcgag gataccgccg tgtactactg tgccagaaga      660

acctactacg ggaacagcta ctacttcgat tactgggggc aggggaccct ggtgaccgtg      720

agcagc                                                                 726


<210>  251

<400>  251
000

<210>  252

<400>  252
000

<210>  253

<400>  253
000

<210>  254

<400>  254
000

<210>  255

<400>  255
000

<210>  256

<400>  256
000

<210>  257

<400>  257
000

<210>  258

<400>  258
000

<210>  259

<400>  259
000

<210>  260
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lead sequence

<400>  260
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60


<210>  261
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD28 transmembrane domain

<400>  261
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  262
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD3 zeta intracellular signaling domain

<400>  262
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgc                             339


<210>  263
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD28 hinge

<400>  263
ctcgaggtga aagggaaaca cctttgtcca agtcccctat ttcccggacc ttctaagccc       60


<210>  264
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD28 costimulatory domain

<400>  264
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tccaagctt                                                              129


<210>  265
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human 4-1BB costimulatory domain

<400>  265
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  266
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human DAP10 costimulatory domain

<400>  266
ctgtgcgcac gcccacgccg cagccccgcc caagaagatg gcaaagtcta catcaacatg       60

ccaggcaggg gc                                                           72


<210>  267
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Glycine-Serine linker unite

<400>  267
ggtggtggtg gttct                                                        15


<210>  268
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (Gly-Gly-Gly-Gly-Ser)X3 linker ((Gly4Ser)3 linker, (G4S)3 linker,
       G4S X3 linker, or G4SX3 linker)

<400>  268
ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttcc                       45


<210>  269
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A ribosomal skip sequence

<400>  269
gccggcgcca aaaggtctgg ctccggtgag ggcagaggaa gtcttctaac atgcggtgac       60

gtggaggaga atcccggccc taga                                              84


<210>  270
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated CD19

<400>  270
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg      960

aggaaaagaa agcgaatgac ttaa                                             984


<210>  271
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h6E6scFvHL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  271
caggtgcagc tggtggagag cggaggaggt gtagttgctc ctggacagag cctgagactg       60

agctgtaccg ccagcgggtt cagcctgagc agctacgggg tgcactgggt gagacagccc      120

cccgggaagg ggctggagtg ggtggccgtg atctgggccg gggggaacac caagtacaac      180

agcgccctga tgagcagatt caccatcagc agagatacca gcaagaccac cgtgtacctg      240

cagatgaaca gcctggagac cgaggatacc gccatgtact actgtgccac ctacttcggg      300

agcagacact tctacagcat ggattactgg gggcagggga ccctggtgac cgtgagcagc      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgatat cgtgctgacc      420

cagagccccg ccaccctgag cgtgagcccc ggggagagag ccaccctgag ctgtagagcc      480

agccagggga tcagcgatta cctgcactgg taccagcaga agagcgggga gagccccaga      540

ctgctgatca agtacgccag ccagagcatg agcgggatcc ccgccagatt cagcgggagc      600

gggagcggga ccgatttcac cctgaccatc agcagcctgg agcccgagga tgtggccgtg      660

tactactgtc agaacgggca caccttcccc ctgaccttcg gggccgggac cagactggag      720

atcaagctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      900

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc      960

ccaccacgcg acttcgcagc ctatcgctcc aagcttagag tgaagttcag caggagcgca     1020

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1080

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1140

ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1200

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1260

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1320

gccctgcccc ctcgc                                                      1335


<210>  272
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h6E6scFvHL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  272
caggtgcagc tggtggagag cggaggaggt gtagttgctc ctggacagag cctgagactg       60

agctgtaccg ccagcgggtt cagcctgagc agctacgggg tgcactgggt gagacagccc      120

cccgggaagg ggctggagtg ggtggccgtg atctgggccg gggggaacac caagtacaac      180

agcgccctga tgagcagatt caccatcagc agagatacca gcaagaccac cgtgtacctg      240

cagatgaaca gcctggagac cgaggatacc gccatgtact actgtgccac ctacttcggg      300

agcagacact tctacagcat ggattactgg gggcagggga ccctggtgac cgtgagcagc      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgatat cgtgctgacc      420

cagagccccg ccaccctgag cgtgagcccc ggggagagag ccaccctgag ctgtagagcc      480

agccagggga tcagcgatta cctgcactgg taccagcaga agagcgggga gagccccaga      540

ctgctgatca agtacgccag ccagagcatg agcgggatcc ccgccagatt cagcgggagc      600

gggagcggga ccgatttcac cctgaccatc agcagcctgg agcccgagga tgtggccgtg      660

tactactgtc agaacgggca caccttcccc ctgaccttcg gggccgggac cagactggag      720

atcaagctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgaaa cggggcagaa agaaactcct gtatatattc      900

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      960

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1020

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1080

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1140

cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1200

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1260

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1320

ctgccccctc gc                                                         1332


<210>  273
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h6E6scFvHL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  273
caggtgcagc tggtggagag cggaggaggt gtagttgctc ctggacagag cctgagactg       60

agctgtaccg ccagcgggtt cagcctgagc agctacgggg tgcactgggt gagacagccc      120

cccgggaagg ggctggagtg ggtggccgtg atctgggccg gggggaacac caagtacaac      180

agcgccctga tgagcagatt caccatcagc agagatacca gcaagaccac cgtgtacctg      240

cagatgaaca gcctggagac cgaggatacc gccatgtact actgtgccac ctacttcggg      300

agcagacact tctacagcat ggattactgg gggcagggga ccctggtgac cgtgagcagc      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgatat cgtgctgacc      420

cagagccccg ccaccctgag cgtgagcccc ggggagagag ccaccctgag ctgtagagcc      480

agccagggga tcagcgatta cctgcactgg taccagcaga agagcgggga gagccccaga      540

ctgctgatca agtacgccag ccagagcatg agcgggatcc ccgccagatt cagcgggagc      600

gggagcggga ccgatttcac cctgaccatc agcagcctgg agcccgagga tgtggccgtg      660

tactactgtc agaacgggca caccttcccc ctgaccttcg gggccgggac cagactggag      720

atcaagctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgctg tgcgcacgcc cacgccgcag ccccgcccaa      900

gaagatggca aagtctacat caacatgcca ggcaggggca gagtgaagtt cagcaggagc      960

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1020

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1080

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1140

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1200

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1260

caggccctgc cccctcgc                                                   1278


<210>  274
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h6E6scFvLH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  274
gatatcgtgc tgacccagag ccccgccacc ctgagcgtga gccccgggga gagagccacc       60

ctgagctgta gagccagcca ggggatcagc gattacctgc actggtacca gcagaagagc      120

ggggagagcc ccagactgct gatcaagtac gccagccaga gcatgagcgg gatccccgcc      180

agattcagcg ggagcgggag cgggaccgat ttcaccctga ccatcagcag cctggagccc      240

gaggatgtgg ccgtgtacta ctgtcagaac gggcacacct tccccctgac cttcggggcc      300

gggaccagac tggagatcaa gggtggtggt ggttctggcg gcggcggctc cggtggtggt      360

ggttcccagg tgcagctggt ggagagcgga ggaggtgtag ttgctcctgg acagagcctg      420

agactgagct gtaccgccag cgggttcagc ctgagcagct acggggtgca ctgggtgaga      480

cagccccccg ggaaggggct ggagtgggtg gccgtgatct gggccggggg gaacaccaag      540

tacaacagcg ccctgatgag cagattcacc atcagcagag ataccagcaa gaccaccgtg      600

tacctgcaga tgaacagcct ggagaccgag gataccgcca tgtactactg tgccacctac      660

ttcgggagca gacacttcta cagcatggat tactgggggc aggggaccct ggtgaccgtg      720

agcagcctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      900

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc      960

ccaccacgcg acttcgcagc ctatcgctcc aagcttagag tgaagttcag caggagcgca     1020

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1080

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1140

ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1200

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1260

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1320

gccctgcccc ctcgc                                                      1335


<210>  275
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h6E6scFvLH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  275
gatatcgtgc tgacccagag ccccgccacc ctgagcgtga gccccgggga gagagccacc       60

ctgagctgta gagccagcca ggggatcagc gattacctgc actggtacca gcagaagagc      120

ggggagagcc ccagactgct gatcaagtac gccagccaga gcatgagcgg gatccccgcc      180

agattcagcg ggagcgggag cgggaccgat ttcaccctga ccatcagcag cctggagccc      240

gaggatgtgg ccgtgtacta ctgtcagaac gggcacacct tccccctgac cttcggggcc      300

gggaccagac tggagatcaa gggtggtggt ggttctggcg gcggcggctc cggtggtggt      360

ggttcccagg tgcagctggt ggagagcgga ggaggtgtag ttgctcctgg acagagcctg      420

agactgagct gtaccgccag cgggttcagc ctgagcagct acggggtgca ctgggtgaga      480

cagccccccg ggaaggggct ggagtgggtg gccgtgatct gggccggggg gaacaccaag      540

tacaacagcg ccctgatgag cagattcacc atcagcagag ataccagcaa gaccaccgtg      600

tacctgcaga tgaacagcct ggagaccgag gataccgcca tgtactactg tgccacctac      660

ttcgggagca gacacttcta cagcatggat tactgggggc aggggaccct ggtgaccgtg      720

agcagcctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgaaa cggggcagaa agaaactcct gtatatattc      900

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      960

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1020

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1080

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1140

cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1200

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1260

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1320

ctgccccctc gc                                                         1332


<210>  276
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h6E6scFvLH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  276
gatatcgtgc tgacccagag ccccgccacc ctgagcgtga gccccgggga gagagccacc       60

ctgagctgta gagccagcca ggggatcagc gattacctgc actggtacca gcagaagagc      120

ggggagagcc ccagactgct gatcaagtac gccagccaga gcatgagcgg gatccccgcc      180

agattcagcg ggagcgggag cgggaccgat ttcaccctga ccatcagcag cctggagccc      240

gaggatgtgg ccgtgtacta ctgtcagaac gggcacacct tccccctgac cttcggggcc      300

gggaccagac tggagatcaa gggtggtggt ggttctggcg gcggcggctc cggtggtggt      360

ggttcccagg tgcagctggt ggagagcgga ggaggtgtag ttgctcctgg acagagcctg      420

agactgagct gtaccgccag cgggttcagc ctgagcagct acggggtgca ctgggtgaga      480

cagccccccg ggaaggggct ggagtgggtg gccgtgatct gggccggggg gaacaccaag      540

tacaacagcg ccctgatgag cagattcacc atcagcagag ataccagcaa gaccaccgtg      600

tacctgcaga tgaacagcct ggagaccgag gataccgcca tgtactactg tgccacctac      660

ttcgggagca gacacttcta cagcatggat tactgggggc aggggaccct ggtgaccgtg      720

agcagcctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgctg tgcgcacgcc cacgccgcag ccccgcccaa      900

gaagatggca aagtctacat caacatgcca ggcaggggca gagtgaagtt cagcaggagc      960

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1020

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1080

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1140

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1200

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1260

caggccctgc cccctcgc                                                   1278


<210>  277
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h6C10scFvHL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  277
caggtgctgg tgcagagcgg ggccgaggtg aagaagcccg gggccagcgt gaaggtgagc       60

tgtaaggcca gcgggtacac cttcaccgat tacaacatgg attgggtgag acagagccac      120

gggcagagcc tggagtggat gggggatatc aaccccaaca ccggggggac catcttcaac      180

cagaagttca aggggagagc caccatcacc gtggatacca gcagcagcac cgcctacatg      240

gatctgcaca gcctgaccag cgaggatacc gccgtgtact actgtgccag aagaacctac      300

tacgggaaca gctactactt cgattactgg gggcagggga ccctggtgac cgtgagcagc      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgatat ccagatgacc      420

cagagccccg ccagcctgag cgccagcgtg ggggagagag tgaccatcac ctgtagagcc      480

agcggggata tccacaacta cctggcctgg taccagcaga agcccgggaa gagcccccag      540

ctgctgatct acaacgccaa gaccctggcc gatggggtgc ccagcagatt cagcgggagc      600

gggagcggga cccagtacac cctgaccatc aacagcctgc agcccgagga tttcgccacc      660

tactactgtc agcacttctg gagcttcccc tggaccttcg ggggggggac caagctggag      720

atcaagctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      900

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc      960

ccaccacgcg acttcgcagc ctatcgctcc aagcttagag tgaagttcag caggagcgca     1020

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1080

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1140

ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1200

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1260

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1320

gccctgcccc ctcgc                                                      1335


<210>  278
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h6C10scFvHL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  278
caggtgctgg tgcagagcgg ggccgaggtg aagaagcccg gggccagcgt gaaggtgagc       60

tgtaaggcca gcgggtacac cttcaccgat tacaacatgg attgggtgag acagagccac      120

gggcagagcc tggagtggat gggggatatc aaccccaaca ccggggggac catcttcaac      180

cagaagttca aggggagagc caccatcacc gtggatacca gcagcagcac cgcctacatg      240

gatctgcaca gcctgaccag cgaggatacc gccgtgtact actgtgccag aagaacctac      300

tacgggaaca gctactactt cgattactgg gggcagggga ccctggtgac cgtgagcagc      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgatat ccagatgacc      420

cagagccccg ccagcctgag cgccagcgtg ggggagagag tgaccatcac ctgtagagcc      480

agcggggata tccacaacta cctggcctgg taccagcaga agcccgggaa gagcccccag      540

ctgctgatct acaacgccaa gaccctggcc gatggggtgc ccagcagatt cagcgggagc      600

gggagcggga cccagtacac cctgaccatc aacagcctgc agcccgagga tttcgccacc      660

tactactgtc agcacttctg gagcttcccc tggaccttcg ggggggggac caagctggag      720

atcaagctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgaaa cggggcagaa agaaactcct gtatatattc      900

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      960

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1020

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1080

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1140

cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1200

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1260

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1320

ctgccccctc gc                                                         1332


<210>  279
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h6C10scFvHL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  279
caggtgctgg tgcagagcgg ggccgaggtg aagaagcccg gggccagcgt gaaggtgagc       60

tgtaaggcca gcgggtacac cttcaccgat tacaacatgg attgggtgag acagagccac      120

gggcagagcc tggagtggat gggggatatc aaccccaaca ccggggggac catcttcaac      180

cagaagttca aggggagagc caccatcacc gtggatacca gcagcagcac cgcctacatg      240

gatctgcaca gcctgaccag cgaggatacc gccgtgtact actgtgccag aagaacctac      300

tacgggaaca gctactactt cgattactgg gggcagggga ccctggtgac cgtgagcagc      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgatat ccagatgacc      420

cagagccccg ccagcctgag cgccagcgtg ggggagagag tgaccatcac ctgtagagcc      480

agcggggata tccacaacta cctggcctgg taccagcaga agcccgggaa gagcccccag      540

ctgctgatct acaacgccaa gaccctggcc gatggggtgc ccagcagatt cagcgggagc      600

gggagcggga cccagtacac cctgaccatc aacagcctgc agcccgagga tttcgccacc      660

tactactgtc agcacttctg gagcttcccc tggaccttcg ggggggggac caagctggag      720

atcaagctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgctg tgcgcacgcc cacgccgcag ccccgcccaa      900

gaagatggca aagtctacat caacatgcca ggcaggggca gagtgaagtt cagcaggagc      960

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1020

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1080

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1140

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1200

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1260

caggccctgc cccctcgc                                                   1278


<210>  280
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h6C10scFvLH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  280
gatatccaga tgacccagag ccccgccagc ctgagcgcca gcgtggggga gagagtgacc       60

atcacctgta gagccagcgg ggatatccac aactacctgg cctggtacca gcagaagccc      120

gggaagagcc cccagctgct gatctacaac gccaagaccc tggccgatgg ggtgcccagc      180

agattcagcg ggagcgggag cgggacccag tacaccctga ccatcaacag cctgcagccc      240

gaggatttcg ccacctacta ctgtcagcac ttctggagct tcccctggac cttcgggggg      300

gggaccaagc tggagatcaa gggtggtggt ggttctggcg gcggcggctc cggtggtggt      360

ggttcccagg tgctggtgca gagcggggcc gaggtgaaga agcccggggc cagcgtgaag      420

gtgagctgta aggccagcgg gtacaccttc accgattaca acatggattg ggtgagacag      480

agccacgggc agagcctgga gtggatgggg gatatcaacc ccaacaccgg ggggaccatc      540

ttcaaccaga agttcaaggg gagagccacc atcaccgtgg ataccagcag cagcaccgcc      600

tacatggatc tgcacagcct gaccagcgag gataccgccg tgtactactg tgccagaaga      660

acctactacg ggaacagcta ctacttcgat tactgggggc aggggaccct ggtgaccgtg      720

agcagcctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      900

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc      960

ccaccacgcg acttcgcagc ctatcgctcc aagcttagag tgaagttcag caggagcgca     1020

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1080

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1140

ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1200

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1260

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1320

gccctgcccc ctcgc                                                      1335


<210>  281
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h6C10scFvLH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  281
gatatccaga tgacccagag ccccgccagc ctgagcgcca gcgtggggga gagagtgacc       60

atcacctgta gagccagcgg ggatatccac aactacctgg cctggtacca gcagaagccc      120

gggaagagcc cccagctgct gatctacaac gccaagaccc tggccgatgg ggtgcccagc      180

agattcagcg ggagcgggag cgggacccag tacaccctga ccatcaacag cctgcagccc      240

gaggatttcg ccacctacta ctgtcagcac ttctggagct tcccctggac cttcgggggg      300

gggaccaagc tggagatcaa gggtggtggt ggttctggcg gcggcggctc cggtggtggt      360

ggttcccagg tgctggtgca gagcggggcc gaggtgaaga agcccggggc cagcgtgaag      420

gtgagctgta aggccagcgg gtacaccttc accgattaca acatggattg ggtgagacag      480

agccacgggc agagcctgga gtggatgggg gatatcaacc ccaacaccgg ggggaccatc      540

ttcaaccaga agttcaaggg gagagccacc atcaccgtgg ataccagcag cagcaccgcc      600

tacatggatc tgcacagcct gaccagcgag gataccgccg tgtactactg tgccagaaga      660

acctactacg ggaacagcta ctacttcgat tactgggggc aggggaccct ggtgaccgtg      720

agcagcctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgaaa cggggcagaa agaaactcct gtatatattc      900

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      960

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1020

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1080

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1140

cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1200

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1260

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1320

ctgccccctc gc                                                         1332


<210>  282
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6C10scFvLH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  282
gatatccaga tgacccagag ccccgccagc ctgagcgcca gcgtggggga gagagtgacc       60

atcacctgta gagccagcgg ggatatccac aactacctgg cctggtacca gcagaagccc      120

gggaagagcc cccagctgct gatctacaac gccaagaccc tggccgatgg ggtgcccagc      180

agattcagcg ggagcgggag cgggacccag tacaccctga ccatcaacag cctgcagccc      240

gaggatttcg ccacctacta ctgtcagcac ttctggagct tcccctggac cttcgggggg      300

gggaccaagc tggagatcaa gggtggtggt ggttctggcg gcggcggctc cggtggtggt      360

ggttcccagg tgctggtgca gagcggggcc gaggtgaaga agcccggggc cagcgtgaag      420

gtgagctgta aggccagcgg gtacaccttc accgattaca acatggattg ggtgagacag      480

agccacgggc agagcctgga gtggatgggg gatatcaacc ccaacaccgg ggggaccatc      540

ttcaaccaga agttcaaggg gagagccacc atcaccgtgg ataccagcag cagcaccgcc      600

tacatggatc tgcacagcct gaccagcgag gataccgccg tgtactactg tgccagaaga      660

acctactacg ggaacagcta ctacttcgat tactgggggc aggggaccct ggtgaccgtg      720

agcagcctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      780

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      840

acagtggcct ttattatttt ctgggtgctg tgcgcacgcc cacgccgcag ccccgcccaa      900

gaagatggca aagtctacat caacatgcca ggcaggggca gagtgaagtt cagcaggagc      960

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1020

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1080

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1140

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1200

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1260

caggccctgc cccctcgc                                                   1278


<210>  283

<400>  283
000

<210>  284

<400>  284
000

<210>  285

<400>  285
000

<210>  286

<400>  286
000

<210>  287

<400>  287
000

<210>  288

<400>  288
000

<210>  289

<400>  289
000

<210>  290

<400>  290
000

<210>  291

<400>  291
000

<210>  292

<400>  292
000

<210>  293

<400>  293
000

<210>  294
<211>  2463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-h6E6scFvLH-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  294
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gatatcgtgc tgacccagag ccccgccacc ctgagcgtga gccccgggga gagagccacc      120

ctgagctgta gagccagcca ggggatcagc gattacctgc actggtacca gcagaagagc      180

ggggagagcc ccagactgct gatcaagtac gccagccaga gcatgagcgg gatccccgcc      240

agattcagcg ggagcgggag cgggaccgat ttcaccctga ccatcagcag cctggagccc      300

gaggatgtgg ccgtgtacta ctgtcagaac gggcacacct tccccctgac cttcggggcc      360

gggaccagac tggagatcaa gggtggtggt ggttctggcg gcggcggctc cggtggtggt      420

ggttcccagg tgcagctggt ggagagcgga ggaggtgtag ttgctcctgg acagagcctg      480

agactgagct gtaccgccag cgggttcagc ctgagcagct acggggtgca ctgggtgaga      540

cagccccccg ggaaggggct ggagtgggtg gccgtgatct gggccggggg gaacaccaag      600

tacaacagcg ccctgatgag cagattcacc atcagcagag ataccagcaa gaccaccgtg      660

tacctgcaga tgaacagcct ggagaccgag gataccgcca tgtactactg tgccacctac      720

ttcgggagca gacacttcta cagcatggat tactgggggc aggggaccct ggtgaccgtg      780

agcagcctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      840

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      900

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc aagcttagag tgaagttcag caggagcgca     1080

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1140

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1200

ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1260

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1320

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1380

gccctgcccc ctcgcgccgg cgccaaaagg tctggctccg gtgagggcag aggaagtctt     1440

ctaacatgcg gtgacgtgga ggagaatccc ggccctagaa tgccacctcc tcgcctcctc     1500

ttcttcctcc tcttcctcac ccccatggaa gtcaggcccg aggaacctct agtggtgaag     1560

gtggaagagg gagataacgc tgtgctgcag tgcctcaagg ggacctcaga tggccccact     1620

cagcagctga cctggtctcg ggagtccccg cttaaaccct tcttaaaact cagcctgggg     1680

ctgccaggcc tgggaatcca catgaggccc ctggccatct ggcttttcat cttcaacgtc     1740

tctcaacaga tggggggctt ctacctgtgc cagccggggc ccccctctga gaaggcctgg     1800

cagcctggct ggacagtcaa tgtggagggc agcggggagc tgttccggtg gaatgtttcg     1860

gacctaggtg gcctgggctg tggcctgaag aacaggtcct cagagggccc cagctcccct     1920

tccgggaagc tcatgagccc caagctgtat gtgtgggcca aagaccgccc tgagatctgg     1980

gagggagagc ctccgtgtct cccaccgagg gacagcctga accagagcct cagccaggac     2040

ctcaccatgg cccctggctc cacactctgg ctgtcctgtg gggtaccccc tgactctgtg     2100

tccaggggcc ccctctcctg gacccatgtg caccccaagg ggcctaagtc attgctgagc     2160

ctagagctga aggacgatcg cccggccaga gatatgtggg taatggagac gggtctgttg     2220

ttgccccggg ccacagctca agacgctgga aagtattatt gtcaccgtgg caacctgacc     2280

atgtcattcc acctggagat cactgctcgg ccagtactat ggcactggct gctgaggact     2340

ggtggctgga aggtctcagc tgtgactttg gcttatctga tcttctgcct gtgttccctt     2400

gtgggcattc ttcatcttca aagagccctg gtcctgagga ggaaaagaaa gcgaatgact     2460

taa                                                                   2463


<210>  295

<400>  295
000

<210>  296

<400>  296
000

<210>  297
<211>  2463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-h6C10scFvHL-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  297
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgctgg tgcagagcgg ggccgaggtg aagaagcccg gggccagcgt gaaggtgagc      120

tgtaaggcca gcgggtacac cttcaccgat tacaacatgg attgggtgag acagagccac      180

gggcagagcc tggagtggat gggggatatc aaccccaaca ccggggggac catcttcaac      240

cagaagttca aggggagagc caccatcacc gtggatacca gcagcagcac cgcctacatg      300

gatctgcaca gcctgaccag cgaggatacc gccgtgtact actgtgccag aagaacctac      360

tacgggaaca gctactactt cgattactgg gggcagggga ccctggtgac cgtgagcagc      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgatat ccagatgacc      480

cagagccccg ccagcctgag cgccagcgtg ggggagagag tgaccatcac ctgtagagcc      540

agcggggata tccacaacta cctggcctgg taccagcaga agcccgggaa gagcccccag      600

ctgctgatct acaacgccaa gaccctggcc gatggggtgc ccagcagatt cagcgggagc      660

gggagcggga cccagtacac cctgaccatc aacagcctgc agcccgagga tttcgccacc      720

tactactgtc agcacttctg gagcttcccc tggaccttcg ggggggggac caagctggag      780

atcaagctcg aggtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      840

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      900

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc aagcttagag tgaagttcag caggagcgca     1080

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1140

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1200

ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1260

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1320

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1380

gccctgcccc ctcgcgccgg cgccaaaagg tctggctccg gtgagggcag aggaagtctt     1440

ctaacatgcg gtgacgtgga ggagaatccc ggccctagaa tgccacctcc tcgcctcctc     1500

ttcttcctcc tcttcctcac ccccatggaa gtcaggcccg aggaacctct agtggtgaag     1560

gtggaagagg gagataacgc tgtgctgcag tgcctcaagg ggacctcaga tggccccact     1620

cagcagctga cctggtctcg ggagtccccg cttaaaccct tcttaaaact cagcctgggg     1680

ctgccaggcc tgggaatcca catgaggccc ctggccatct ggcttttcat cttcaacgtc     1740

tctcaacaga tggggggctt ctacctgtgc cagccggggc ccccctctga gaaggcctgg     1800

cagcctggct ggacagtcaa tgtggagggc agcggggagc tgttccggtg gaatgtttcg     1860

gacctaggtg gcctgggctg tggcctgaag aacaggtcct cagagggccc cagctcccct     1920

tccgggaagc tcatgagccc caagctgtat gtgtgggcca aagaccgccc tgagatctgg     1980

gagggagagc ctccgtgtct cccaccgagg gacagcctga accagagcct cagccaggac     2040

ctcaccatgg cccctggctc cacactctgg ctgtcctgtg gggtaccccc tgactctgtg     2100

tccaggggcc ccctctcctg gacccatgtg caccccaagg ggcctaagtc attgctgagc     2160

ctagagctga aggacgatcg cccggccaga gatatgtggg taatggagac gggtctgttg     2220

ttgccccggg ccacagctca agacgctgga aagtattatt gtcaccgtgg caacctgacc     2280

atgtcattcc acctggagat cactgctcgg ccagtactat ggcactggct gctgaggact     2340

ggtggctgga aggtctcagc tgtgactttg gcttatctga tcttctgcct gtgttccctt     2400

gtgggcattc ttcatcttca aagagccctg gtcctgagga ggaaaagaaa gcgaatgact     2460

taa                                                                   2463


