                         SEQUENCE LISTING

<110>  The University of Alabama Research Foundation
 
<120>  METHOD FOR INCREASING CELL SUSCEPTIBILITY TO COMPLEMENT-MEDIATED 
       LYSIS

<130>  222104-2940

<150>  62/821,641
<151>  2019-03-21

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pig CD46 gRNA-1 primer

<400>  1
caccgctcat ggacccctat tgacg                                             25


<210>  2
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pig CD46 gRNA-2 primer

<400>  2
aaaccgtcaa taggggtcca tgagc                                             25


<210>  3
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pig CD55 gRNA-1 primer

<400>  3
caccggcgcc atgagtcccc tgccg                                             25


<210>  4
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pig CD55 gRNA-2 primer

<400>  4
aaaccggcag gggactcatg gcgcc                                             25


<210>  5
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pig CD59 gRNA-1 primer

<400>  5
caccgaatcc atagacggtc acgat                                             25


<210>  6
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pig CD59 gRNA-2 primer

<400>  6
aaacatcgtg accgtctatg gattc                                             25


<210>  7
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human CD46 gRNA-1 primer

<400>  7
caccggcgcc gcgcatggag cctcc                                             25


<210>  8
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human CD46 gRNA-2 primer

<400>  8
aaacggaggc tccatgcgcg gcgcc                                             25


<210>  9
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human CD55 gRNA-1 primer

<400>  9
caccgggcgc gccatgaccg tcgcg                                             25


<210>  10
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human CD55 gRNA-2 primer

<400>  10
aaaccgcgac ggtcatggcg cgccc                                             25


<210>  11
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human CD59 gRNA-1 primer

<400>  11
caccgatcac aatgggaatc caagg                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human CD59 gRNA-2 primer

<400>  12
aaacccttgg attcccattg tgatc                                             25


<210>  13
<211>  634
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pig CD46 in PX330

<400>  13
ttggggttcg atttcttggc tttatatatc ttgtggaagg acgaaacacc gctcatggac       60

ccctattgac ggttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa      120

cttgaaaaag tggcaccgag tcggtgcttt tttgttttag agctagaaat agcaagttaa      180

aataaggcta gtccgttttt agcgcgtgcg ccaattctgc agacaaatgg ctctagaggt      240

acccgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc      300

attgacgtca atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt      360

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat      420

tgacgtcaat gacggtaaat ggcccgcctg gcattgtgcc cagtacatga ccttatggga      480

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggg                                  634


<210>  14
<211>  624
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pig CD55 in PX458

<400>  14
gcggattcga tttcttggct ttatatatct tgtggaagga cgaaacaccg gcgccatgag       60

tcccctgccg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      120

ttgaaaaagt ggcaccgagt cggtgctttt ttgttttaga gctagaaata gcaagttaaa      180

ataaggctag tccgttttta gcgcgtgcgc caattctgca gacaaatggc tctagaggta      240

cccgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      300

ttgacgtcaa tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattgtgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgca                                             624


<210>  15
<211>  634
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pig CD59 in PX330

<400>  15
cggaatccgg atttcttggc tttaatatct tgtggaagga cgaaacaccg aatccataga       60

cggtcacgat gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      120

ttgaaaaagt ggcaccgagt cggtgctttt ttgttttaga gctagaaata gcaagttaaa      180

ataaggctag tccgttttta gcgcgtgcgc caattctgca gacaaatggc tctagaggta      240

cccgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      300

ttgacgtcaa tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattgtgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg gggg                                  634


<210>  16
<211>  603
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human CD46 in PX468

<400>  16
tcgggttcga tttcttggct ttatatatct tgtggaagga cgaaacaccg gcgccgcgca       60

tggagcctcc gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      120

ttgaaaaagt ggcaccgagt cggtgctttt ttgttttaga gctagaaata gcaagttaaa      180

ataaggctag tccgttttta gcgcgtgcgc caattctgca gacaaatggc tctagaggta      240

cccgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      300

ttgacgtcaa tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattgtgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

ttt                                                                    603


<210>  17
<211>  616
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human CD55 in PX330

<400>  17
acgtatcgat ttcttggctt tatatatctt gtggaaggac gaaacaccgg gcgcgccatg       60

accgtcgcgg ttttagagct agaaatagca agttaaaata aggctagtcc gttatcaact      120

tgaaaaagtg gcaccgagtc ggtgcttttt tgttttagag ctagaaatag caagttaaaa      180

taaggctagt ccgtttttag cgcgtgcgcc aattctgcag acaaatggct ctagaggtac      240

ccgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat      300

tgacgtcaat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac      360

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg      420

acgtcaatga cggtaaatgg cccgcctggc attgtgccca gtacatgacc ttatgggact      480

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtc gaggtgagcc      540

ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat      600

ttatttttta attatt                                                      616


<210>  18
<211>  619
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human CD59 in PX330

<400>  18
tcggttgcga tttcttggct ttatatatct tgtggaagga cgaaacaccg atcacaatgg       60

gaatccaagg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      120

ttgaaaaagt ggcaccgagt cggtgctttt ttgttttaga gctagaaata gcaagttaaa      180

ataaggctag tccgttttta gcgcgtgcgc caattctgca gacaaatggc tctagaggta      240

cccgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      300

ttgacgtcaa tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattgtgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattatttt                                                   619


<210>  19
<211>  2675
<212>  DNA
<213>  Sus scrofa

<400>  19
ttgttgcgtc tggtaagcct accctaaaag ctgtctcatg ggttggcctc agatttcccg       60

ctgatttccc caaacatgac ggtggcttgc gcaccgcgca aggcacctcc cgagcgccca      120

gagaggcctc ctttttcctg gtgctgcgtg gggattcttt tgctggcttt agtgttcccg      180

ctacccttat tcgccttcgt tgtctgtcct gatccaccga aactgaagag tgcggtgctc      240

acgagtgtcc ttcaacaacg ttattatcct ggggacaaaa tagagtatcg gtgtcgccca      300

ggataccttc cagatccatt tgaaacccgg aaatcttcct gtgaggcaaa tggctcatgg      360

acccctattg acgaggcttg ttttcgaaaa tcatgtccga aaccaacaat agaacatggt      420

gaaatatatg cccctcaaag aaactttgag tttgaatcag aagttcacat ttcgtgtatt      480

gaaggttacc atttaaaagg gaaaggtatt ctaacttgtc aacttattgg acaggacgtg      540

ttttggagtg atagaatgcc acaatgtgaa agggtttact gtggacgacc tccacaaata      600

aaaaatggaa aacataccaa tagctacagg aatatatttg aatataatga attagtaact      660

tatacttgta atccttcaaa tggaccagat gaatattcac ttgttggaga aagcaaactt      720

ttttgttctg cacctggcaa atggagtagt gcccctcctc agtgtaaagt ggtcaaatgt      780

gaacgtccag aactcaaaca tggagtcata gtatcgggaa gtagagaaaa attttcctac      840

caagcagtgg tgatatttgg atgcctgcaa ggtttttacc ttaatggcag caacgtggtg      900

ttctgtagtg gtaataatac atgggagcct gagataccaa agtgtattaa aggttacagg      960

ccaacttatc caaccaagaa tccagttgac aaatatccag gctatcctaa tcccgatttt     1020

gaaataccat cacttgacga ctttgaggat ttagatgccg gaatcattgc tcttatggct     1080

cttactgcaa ttgttgctgt tgcagtagtt ttcacctgcc tatacagatg tcttcgcagt     1140

gagaaggagg tggtgaagga taagaaaggg gaggaggaag aggagcagaa ggaggagaag     1200

aaggagaaag aggaggaaac agagaaaaag gaggagaagg agaagaagaa agagaaggag     1260

aaggagaaga aagagaagaa gaaaaaaggg aaaaaagaag ctggtgctgt atccgctact     1320

caaatggaaa aaccaaccag tccatcagtg cagaagcact aatttttctt ccacaaaccc     1380

atatatcagt ttatcttttg attctgttaa tatgttaaga tctacagtaa attcatacag     1440

aaactatgga aaaccatatg taggttcctc aaaaaattaa aaatagagct actatatgat     1500

ccagcaattc cactgtaggt atatatccaa agaaaacaaa atcaccagtg gaagagataa     1560

cagcacccac tgtgtaatgc agcattgttt acagtaacca caatatggaa acagcctaag     1620

tgtccagtgt caaatgaatg ggtgaagaga atgtgaggta gatatataga tacacacaca     1680

cacacacaca cacacacaca cacctacacc tatatataca ttcataaata gatacagaca     1740

gtggaatacc attcaaccat taaaaagaaa gccctgccat atgtgacaat acttatgaaa     1800

cttgagcaca ttatggtaag taaataagtc gtacagaaag acacaaatac tctatgatct     1860

cacttatagg tagaatccaa aaatccacac acagaaaaag aaatcagatt tctggttgcc     1920

agaggcaggg gatgagggtg gtgtaagaaa tgggtgaaag gtgtcaaaag gtacaaagta     1980

gcaggtataa gataagtact aggatatcat gtacagcatg gtgactataa ttagtaatgc     2040

tgtgttgtat acagctggct ctgtatttga tggtccccca tccatatctg tggctatgga     2100

gagctggttg tgctttgcca caatatataa gagacttgag cattcaggat tttatttgta     2160

ggggaagagg atgggaatct ggaaccaatc cccctcatat atcaagggat gacagcttta     2220

caagttgtta gagggtaggt ctttgatgtt ctgatcacaa ggaagaataa aaaaaatttt     2280

gtaactatga gaggtgatgc atattaagaa tttattgtaa tcatttcata atatttacat     2340

tatcaagtca tgctgtatac cctcaactta aacagtttta cacaggttac ctccttttct     2400

tcttcacttt gtcacacgtt gcagagatgg caattttcac agtttatggc aaccctacac     2460

cagcaagttt attggtgcca ttttcgcaac aacatttact cattttgtgt ctctgtgtca     2520

cattttggta attcatgcag tatttaaatt ttttattatc atcattctgt ttgttatggt     2580

gatctctgtt caattatatt tcatgtcact gctgttattc actgaagatg caaatgatta     2640

ttagtacttt tagcaataaa ttatttttta attaa                                2675


<210>  20
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pig CD46 crispr target

<400>  20
gcatgggaag caggaacact a                                                 21


<210>  21
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro 
        275                 280                 285             


Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser 
    290                 295                 300                 


Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr 
305                 310                 315                 320 


Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu 
                325                 330                 335     


Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile 
            340                 345                 350         


Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr 
        355                 360                 365             


Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu Thr His 
    370                 375                 380                 


Arg Glu Val Lys Phe Thr Ser Leu 
385                 390         


<210>  22
<211>  378
<212>  PRT
<213>  Sus scrofa

<400>  22

Met Met Ala Phe Cys Ala Leu Arg Lys Ala Leu Pro Cys Arg Pro Glu 
1               5                   10                  15      


Asn Pro Phe Ser Ser Arg Cys Phe Val Glu Ile Leu Trp Val Ser Leu 
            20                  25                  30          


Ala Leu Val Phe Leu Leu Pro Met Pro Ser Asp Ala Cys Asp Glu Pro 
        35                  40                  45              


Pro Lys Phe Glu Ser Met Arg Pro Gln Val Leu Asn Thr Thr Tyr Arg 
    50                  55                  60                  


Pro Gly Asp Arg Val Glu Tyr Glu Cys Arg Pro Gly Phe Gln Pro Met 
65                  70                  75                  80  


Val Pro Ala Leu Pro Thr Ser Ser Val Cys Gln Asp Asp Asn Thr Trp 
                85                  90                  95      


Ser Pro Leu Gln Glu Ala Cys Arg Arg Lys Ala Cys Ser Asn Leu Pro 
            100                 105                 110         


Asp Pro Leu Asn Gly Gln Val Ser Tyr Pro Asn Gly Asp Thr Leu Phe 
        115                 120                 125             


Gly Ser Lys Ala Gln Phe Thr Cys Asn Thr Gly Phe Tyr Ile Ile Gly 
    130                 135                 140                 


Ala Glu Thr Val Tyr Cys Gln Val Ser Gly Asn Val Met Ala Trp Ser 
145                 150                 155                 160 


Glu Pro Ser Pro Leu Cys Glu Lys Ile Leu Cys Lys Pro Pro Gly Glu 
                165                 170                 175     


Ile Pro Asn Gly Lys Tyr Thr Asn Ser His Lys Asp Val Phe Glu Tyr 
            180                 185                 190         


Asn Glu Val Val Thr Tyr Ser Cys Leu Ser Ser Thr Gly Pro Asp Glu 
        195                 200                 205             


Phe Ser Leu Val Gly Glu Ser Ser Leu Phe Cys Ile Gly Lys Asp Glu 
    210                 215                 220                 


Trp Ser Ser Asp Pro Pro Glu Cys Lys Val Val Lys Cys Pro Tyr Pro 
225                 230                 235                 240 


Val Val Pro Asn Gly Glu Ile Val Ser Gly Phe Gly Ser Lys Phe Tyr 
                245                 250                 255     


Tyr Lys Ala Glu Val Val Phe Lys Cys Asn Ala Gly Phe Thr Leu His 
            260                 265                 270         


Gly Arg Asp Thr Ile Val Cys Gly Ala Asn Ser Thr Trp Glu Pro Glu 
        275                 280                 285             


Met Pro Gln Cys Ile Lys Glu Ser Thr Pro Pro Asn Thr Gln Pro Pro 
    290                 295                 300                 


Thr Pro Ser Val Ser Asp Ser Lys Pro Thr Asp Pro Pro Ala Thr Pro 
305                 310                 315                 320 


Gly Pro Ser His Pro Gly Pro Pro Ser Pro Ser Asp Ala Ser Pro Pro 
                325                 330                 335     


Lys Asp Ala Glu Ser Leu Asp Gly Gly Ile Ile Ala Ala Ile Val Val 
            340                 345                 350         


Gly Val Leu Ala Ala Ile Ala Val Ile Ala Gly Gly Val Tyr Phe Phe 
        355                 360                 365             


His His Lys Tyr Asn Lys Lys Arg Ser Lys 
    370                 375             


<210>  23
<211>  427
<212>  PRT
<213>  Sus scrofa

<400>  23

Met Thr Val Ala Cys Ala Pro Arg Lys Ala Pro Pro Glu Arg Pro Glu 
1               5                   10                  15      


Arg Pro Pro Phe Ser Trp Cys Cys Val Gly Ile Leu Leu Leu Ala Leu 
            20                  25                  30          


Val Phe Pro Leu Pro Leu Phe Ala Phe Val Val Cys Pro Asp Pro Pro 
        35                  40                  45              


Lys Leu Lys Ser Ala Val Leu Thr Ser Val Leu Gln Gln Arg Tyr Tyr 
    50                  55                  60                  


Pro Gly Asp Lys Ile Glu Tyr Arg Cys Arg Pro Gly Tyr Leu Pro Asp 
65                  70                  75                  80  


Pro Phe Glu Thr Arg Lys Ser Ser Cys Glu Ala Asn Gly Ser Trp Thr 
                85                  90                  95      


Pro Ile Asp Glu Ala Cys Phe Arg Lys Ser Cys Pro Lys Pro Thr Ile 
            100                 105                 110         


Glu His Gly Ile Tyr Ala Pro Gln Arg Asn Phe Glu Phe Glu Ser Glu 
        115                 120                 125             


Val His Ile Ser Cys Ile Glu Gly Tyr His Leu Lys Gly Lys Gly Ile 
    130                 135                 140                 


Leu Thr Cys Gln Leu Ile Gly Gln Asp Val Phe Trp Ser Asp Arg Met 
145                 150                 155                 160 


Pro Gln Cys Glu Arg Val Tyr Cys Gly Arg Pro Pro Gln Ile Lys Asn 
                165                 170                 175     


Gly Lys His Thr Asn Ser Tyr Arg Asn Ile Phe Glu Tyr Asn Glu Leu 
            180                 185                 190         


Val Thr Tyr Thr Cys Asn Pro Ser Asn Gly Pro Asp Glu Tyr Ser Leu 
        195                 200                 205             


Val Gly Glu Ser Lys Leu Phe Cys Ser Ala Pro Gly Lys Trp Ser Ser 
    210                 215                 220                 


Ala Pro Pro Gln Cys Lys Val Val Lys Cys Glu Arg Pro Glu Leu Lys 
225                 230                 235                 240 


His Gly Val Ile Val Ser Gly Ser Arg Glu Lys Phe Ser Tyr Gln Ala 
                245                 250                 255     


Val Val Ile Phe Gly Cys Leu Gln Gly Phe Tyr Leu Asn Gly Ser Asn 
            260                 265                 270         


Val Val Phe Cys Ser Gly Asn Asn Thr Trp Glu Pro Glu Ile Pro Lys 
        275                 280                 285             


Cys Ile Lys Gly Tyr Arg Pro Thr Tyr Pro Thr Lys Asn Pro Val Asp 
    290                 295                 300                 


Lys Tyr Pro Gly Tyr Pro Asn Pro Asp Phe Glu Ile Pro Ser Leu Asp 
305                 310                 315                 320 


Asp Phe Glu Asp Leu Asp Ala Gly Ile Ile Ala Leu Met Ala Leu Thr 
                325                 330                 335     


Ala Ile Val Ala Val Ala Val Val Phe Thr Cys Leu Tyr Arg Cys Leu 
            340                 345                 350         


Arg Ser Glu Lys Glu Val Val Lys Asp Lys Lys Gly Glu Glu Glu Glu 
        355                 360                 365             


Glu Gln Lys Glu Glu Lys Lys Glu Lys Glu Glu Glu Thr Glu Lys Lys 
    370                 375                 380                 


Glu Glu Lys Glu Lys Lys Lys Glu Lys Glu Lys Glu Lys Lys Glu Lys 
385                 390                 395                 400 


Lys Lys Lys Gly Lys Lys Glu Ala Gly Ala Val Ser Ala Thr Gln Met 
                405                 410                 415     


Glu Lys Pro Thr Ser Pro Ser Val Gln Lys His 
            420                 425         


