                         SEQUENCE LISTING

<110>  Janssen Pharmaceuticals, Inc.
       GlaxoSmithKline Biologicals S.A.
 
<120>  Bioconjugates of E. coli O-Antigen Polysaccharides, Methods of 
       Production Thereof, and Methods of Use Thereof

<130>  004852.11560/90WO1 (CRU6008WOPCT1;VB66554P)

<150>  US62/819,746 

<151>  2019-03-18

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glycosylation consensus sequence


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  any amino acid residue except Pro

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Ser orThr

<400>  1

Asn Xaa Xaa 
1           


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  optimized glycosylation consensus sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Asp or Glu

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  any amino acid residue except Pro

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  any amino acid residue except Pro

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Ser or Thr

<400>  2

Xaa Xaa Asn Xaa Xaa 
1               5   


<210>  3
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPA carrier protein comprising 4 glycosylation consensus 
       sequences (EPA-4)

<400>  3

Gly Ser Gly Gly Gly Asp Gln Asn Ala Thr Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Leu Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
            20                  25                  30          


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
        35                  40                  45              


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met 
    50                  55                  60                  


Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala 
65                  70                  75                  80  


Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val 
                85                  90                  95      


Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly 
            100                 105                 110         


Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser 
        115                 120                 125             


Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser 
    130                 135                 140                 


His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala 
145                 150                 155                 160 


Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn 
                165                 170                 175     


Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val 
            180                 185                 190         


Met Ala Gln Ala Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala 
        195                 200                 205             


Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn 
    210                 215                 220                 


Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys 
225                 230                 235                 240 


Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile 
                245                 250                 255     


Lys Asp Asn Asn Asn Ser Thr Pro Thr Val Ile Ser His Arg Leu His 
            260                 265                 270         


Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys 
        275                 280                 285             


His Leu Pro Leu Glu Ala Phe Thr Arg His Arg Gln Pro Arg Gly Trp 
    290                 295                 300                 


Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu 
305                 310                 315                 320 


Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg 
                325                 330                 335     


Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile 
            340                 345                 350         


Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala 
        355                 360                 365             


Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly 
    370                 375                 380                 


Ala Ala Ser Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Lys Asp 
385                 390                 395                 400 


Gln Asn Arg Thr Lys Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp 
                405                 410                 415     


Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp 
            420                 425                 430         


Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val 
        435                 440                 445             


Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val 
    450                 455                 460                 


Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val 
465                 470                 475                 480 


Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg 
                485                 490                 495     


Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln 
            500                 505                 510         


Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu 
        515                 520                 525             


Arg Val Tyr Val Pro Arg Trp Ser Leu Pro Gly Phe Tyr Arg Thr Gly 
    530                 535                 540                 


Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile 
545                 550                 555                 560 


Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu 
                565                 570                 575     


Glu Gly Gly Arg Val Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr 
            580                 585                 590         


Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly 
        595                 600                 605             


Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala 
    610                 615                 620                 


Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu 
625                 630                 635                 640 


Lys Leu Gly Ser Gly Gly Gly Asp Gln Asn Ala Thr 
                645                 650         


<210>  4
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O4 GtrS amino acid sequence

<400>  4

Met Asn Asn Leu Ile Met Asn Asn Trp Cys Lys Leu Ser Ile Phe Ile 
1               5                   10                  15      


Ile Ala Phe Ile Leu Leu Trp Leu Arg Arg Pro Asp Ile Leu Thr Asn 
            20                  25                  30          


Ala Gln Phe Trp Ala Glu Asp Ser Val Phe Trp Tyr Lys Asp Ala Tyr 
        35                  40                  45              


Glu Asn Gly Phe Leu Ser Ser Leu Thr Thr Pro Arg Asn Gly Tyr Phe 
    50                  55                  60                  


Gln Thr Val Ser Thr Phe Ile Val Gly Leu Thr Ala Leu Leu Asn Pro 
65                  70                  75                  80  


Asp Tyr Ala Pro Phe Val Ser Asn Phe Phe Gly Ile Met Ile Arg Ser 
                85                  90                  95      


Val Ile Ile Trp Phe Leu Phe Thr Glu Arg Phe Asn Phe Leu Thr Leu 
            100                 105                 110         


Thr Thr Arg Ile Phe Leu Ser Ile Tyr Phe Leu Cys Met Pro Gly Leu 
        115                 120                 125             


Asp Glu Val His Ala Asn Ile Thr Asn Ala His Trp Tyr Leu Ser Leu 
    130                 135                 140                 


Tyr Val Ser Met Ile Leu Ile Ala Arg Asn Pro Ser Ser Lys Ser Trp 
145                 150                 155                 160 


Arg Phe His Asp Ile Phe Phe Ile Leu Leu Ser Gly Leu Ser Gly Pro 
                165                 170                 175     


Phe Ile Ile Phe Ile Leu Ala Ala Ser Cys Phe Lys Phe Ile Asn Asn 
            180                 185                 190         


Cys Lys Asp His Ile Ser Val Arg Ser Phe Ile Asn Phe Tyr Leu Arg 
        195                 200                 205             


Gln Pro Tyr Ala Leu Met Ile Val Cys Ala Leu Ile Gln Gly Thr Ser 
    210                 215                 220                 


Ile Ile Leu Thr Phe Asn Gly Thr Arg Ser Ser Ala Pro Leu Gly Phe 
225                 230                 235                 240 


Ser Phe Asp Val Ile Ser Ser Ile Ile Ser Ser Asn Ile Phe Leu Phe 
                245                 250                 255     


Thr Phe Val Pro Trp Asp Ile Ala Lys Ala Gly Trp Asp Asn Leu Leu 
            260                 265                 270         


Leu Ser Tyr Phe Leu Ser Val Ser Ile Leu Ser Cys Ala Ala Phe Val 
        275                 280                 285             


Phe Val Lys Gly Thr Trp Arg Met Lys Val Phe Ala Thr Leu Pro Leu 
    290                 295                 300                 


Leu Ile Ile Ile Phe Ser Met Ala Lys Pro Gln Leu Thr Asp Ser Ala 
305                 310                 315                 320 


Pro Gln Leu Pro Thr Leu Ile Asn Gly Gln Gly Ser Arg Tyr Phe Val 
                325                 330                 335     


Asn Ile His Ile Ala Ile Phe Ser Leu Leu Cys Val Tyr Leu Leu Glu 
            340                 345                 350         


Cys Val Arg Gly Lys Val Ala Thr Leu Phe Ser Lys Ile Tyr Leu Thr 
        355                 360                 365             


Ile Leu Leu Phe Val Met Gly Cys Leu Asn Phe Val Ile Thr Pro Leu 
    370                 375                 380                 


Pro Asn Met Asn Trp Arg Glu Gly Ala Thr Leu Ile Asn Asn Ala Lys 
385                 390                 395                 400 


Thr Gly Asp Val Ile Ser Ile Gln Val Leu Pro Pro Gly Leu Thr Leu 
                405                 410                 415     


Glu Leu Arg Lys Lys 
            420     


<210>  5
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Example O4 gtrS nucleic acid sequence

<400>  5
atgaataatt taattatgaa taactggtgt aaattatcta tatttattat tgcatttatt       60

ttgctatggc ttagaaggcc ggatatactc acaaacgcac aattttgggc agaagattcc      120

gttttctggt ataaggacgc ctatgagaac ggattcttaa gttcactaac aacgcctagg      180

aatgggtatt tccagactgt ttctacattt atagttggtc tgactgcttt attaaatcca      240

gattatgcac cttttgtttc taattttttt ggcataatga ttcgctcagt aattatatgg      300

tttttattta cagaaagatt caacttcctc acattgacta ctaggatttt cttatctatt      360

tattttctat gcatgcctgg attggatgaa gttcatgcaa atataacaaa tgcacattgg      420

tatttgtcat tatatgtatc aatgatcctg atagctcgca atccaagttc aaaatcatgg      480

aggtttcatg atatattctt tatcttgcta tccgggctca gtggcccatt tataattttc      540

attttagcag cttcatgctt taaatttata aataattgta aagatcatat tagtgtaaga      600

tctttcataa atttctactt gcgtcagcca tacgcattaa tgattgtttg cgctttaatt      660

caaggaactt ctataattct aactttcaat ggcacacgtt cctcagcacc gctaggattc      720

agttttgatg tgatttcgtc tattatatca tcgaatattt ttttatttac atttgtccca      780

tgggatattg caaaggctgg gtgggataat ttactgttat cttatttttt gtctgtttcg      840

attttgtcgt gtgcggcctt tgtttttgtt aaaggtacgt ggcgaatgaa agtatttgca      900

actttaccat tgctaattat aatattttca atggcaaaac cacaattgac agactcggca      960

cctcaattgc caacacttat taatgggcaa ggttcaagat acttcgtaaa tatacatatt     1020

gcgatattct ctttgctatg tgtttactta cttgagtgcg tcagggggaa agtggcaact     1080

ttattttcca aaatatactt aacaattttg ctattcgtga tgggatgttt gaattttgtt     1140

atcaccccac tcccaaacat gaactggagg gaaggtgcta ctttgattaa taatgcaaaa     1200

actggtgatg tcatttcgat tcaagtgcta ccacctggcc taacacttga actaaggaaa     1260

aaataa                                                                1266


<210>  6
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example PglB sequence ('wild-type')

<400>  6

Met Leu Lys Lys Glu Tyr Leu Lys Asn Pro Tyr Leu Val Leu Phe Ala 
1               5                   10                  15      


Met Ile Ile Leu Ala Tyr Val Phe Ser Val Phe Cys Arg Phe Tyr Trp 
            20                  25                  30          


Val Trp Trp Ala Ser Glu Phe Asn Glu Tyr Phe Phe Asn Asn Gln Leu 
        35                  40                  45              


Met Ile Ile Ser Asn Asp Gly Tyr Ala Phe Ala Glu Gly Ala Arg Asp 
    50                  55                  60                  


Met Ile Ala Gly Phe His Gln Pro Asn Asp Leu Ser Tyr Tyr Gly Ser 
65                  70                  75                  80  


Ser Leu Ser Ala Leu Thr Tyr Trp Leu Tyr Lys Ile Thr Pro Phe Ser 
                85                  90                  95      


Phe Glu Ser Ile Ile Leu Tyr Met Ser Thr Phe Leu Ser Ser Leu Val 
            100                 105                 110         


Val Ile Pro Thr Ile Leu Leu Ala Asn Glu Tyr Lys Arg Pro Leu Met 
        115                 120                 125             


Gly Phe Val Ala Ala Leu Leu Ala Ser Ile Ala Asn Ser Tyr Tyr Asn 
    130                 135                 140                 


Arg Thr Met Ser Gly Tyr Tyr Asp Thr Asp Met Leu Val Ile Val Leu 
145                 150                 155                 160 


Pro Met Phe Ile Leu Phe Phe Met Val Arg Met Ile Leu Lys Lys Asp 
                165                 170                 175     


Phe Phe Ser Leu Ile Ala Leu Pro Leu Phe Ile Gly Ile Tyr Leu Trp 
            180                 185                 190         


Trp Tyr Pro Ser Ser Tyr Thr Leu Asn Val Ala Leu Ile Gly Leu Phe 
        195                 200                 205             


Leu Ile Tyr Thr Leu Ile Phe His Arg Lys Glu Lys Ile Phe Tyr Ile 
    210                 215                 220                 


Ala Val Ile Leu Ser Ser Leu Thr Leu Ser Asn Ile Ala Trp Phe Tyr 
225                 230                 235                 240 


Gln Ser Ala Ile Ile Val Ile Leu Phe Ala Leu Phe Ala Leu Glu Gln 
                245                 250                 255     


Lys Arg Leu Asn Phe Met Ile Ile Gly Ile Leu Gly Ser Ala Thr Leu 
            260                 265                 270         


Ile Phe Leu Ile Leu Ser Gly Gly Val Asp Pro Ile Leu Tyr Gln Leu 
        275                 280                 285             


Lys Phe Tyr Ile Phe Arg Ser Asp Glu Ser Ala Asn Leu Thr Gln Gly 
    290                 295                 300                 


Phe Met Tyr Phe Asn Val Asn Gln Thr Ile Gln Glu Val Glu Asn Val 
305                 310                 315                 320 


Asp Leu Ser Glu Phe Met Arg Arg Ile Ser Gly Ser Glu Ile Val Phe 
                325                 330                 335     


Leu Phe Ser Leu Phe Gly Phe Val Trp Leu Leu Arg Lys His Lys Ser 
            340                 345                 350         


Met Ile Met Ala Leu Pro Ile Leu Val Leu Gly Phe Leu Ala Leu Lys 
        355                 360                 365             


Gly Gly Leu Arg Phe Thr Ile Tyr Ser Val Pro Val Met Ala Leu Gly 
    370                 375                 380                 


Phe Gly Phe Leu Leu Ser Glu Phe Lys Ala Ile Met Val Lys Lys Tyr 
385                 390                 395                 400 


Ser Gln Leu Thr Ser Asn Val Cys Ile Val Phe Ala Thr Ile Leu Thr 
                405                 410                 415     


Leu Ala Pro Val Phe Ile His Ile Tyr Asn Tyr Lys Ala Pro Thr Val 
            420                 425                 430         


Phe Ser Gln Asn Glu Ala Ser Leu Leu Asn Gln Leu Lys Asn Ile Ala 
        435                 440                 445             


Asn Arg Glu Asp Tyr Val Val Thr Trp Trp Asp Tyr Gly Tyr Pro Val 
    450                 455                 460                 


Arg Tyr Tyr Ser Asp Val Lys Thr Leu Val Asp Gly Gly Lys His Leu 
465                 470                 475                 480 


Gly Lys Asp Asn Phe Phe Pro Ser Phe Ala Leu Ser Lys Asp Glu Gln 
                485                 490                 495     


Ala Ala Ala Asn Met Ala Arg Leu Ser Val Glu Tyr Thr Glu Lys Ser 
            500                 505                 510         


Phe Tyr Ala Pro Gln Asn Asp Ile Leu Lys Thr Asp Ile Leu Gln Ala 
        515                 520                 525             


Met Met Lys Asp Tyr Asn Gln Ser Asn Val Asp Leu Phe Leu Ala Ser 
    530                 535                 540                 


Leu Ser Lys Pro Asp Phe Lys Ile Asp Thr Pro Lys Thr Arg Asp Ile 
545                 550                 555                 560 


Tyr Leu Tyr Met Pro Ala Arg Met Ser Leu Ile Phe Ser Thr Val Ala 
                565                 570                 575     


Ser Phe Ser Phe Ile Asn Leu Asp Thr Gly Val Leu Asp Lys Pro Phe 
            580                 585                 590         


Thr Phe Ser Thr Ala Tyr Pro Leu Asp Val Lys Asn Gly Glu Ile Tyr 
        595                 600                 605             


Leu Ser Asn Gly Val Val Leu Ser Asp Asp Phe Arg Ser Phe Lys Ile 
    610                 615                 620                 


Gly Asp Asn Val Val Ser Val Asn Ser Ile Val Glu Ile Asn Ser Ile 
625                 630                 635                 640 


Lys Gln Gly Glu Tyr Lys Ile Thr Pro Ile Asp Asp Lys Ala Gln Phe 
                645                 650                 655     


Tyr Ile Phe Tyr Leu Lys Asp Ser Ala Ile Pro Tyr Ala Gln Phe Ile 
            660                 665                 670         


Leu Met Asp Lys Thr Met Phe Asn Ser Ala Tyr Val Gln Met Phe Phe 
        675                 680                 685             


Leu Gly Asn Tyr Asp Lys Asn Leu Phe Asp Leu Val Ile Asn Ser Arg 
    690                 695                 700                 


Asp Ala Lys Val Phe Lys Leu Lys Ile 
705                 710             


<210>  7
<211>  120
<212>  PRT
<213>  Escherichia coli

<400>  7

Met Leu Lys Leu Phe Ala Lys Tyr Thr Ser Ile Gly Val Leu Asn Thr 
1               5                   10                  15      


Leu Ile His Trp Val Val Phe Gly Val Cys Ile Tyr Val Ala His Thr 
            20                  25                  30          


Asn Gln Ala Leu Ala Asn Phe Ala Gly Phe Val Val Ala Val Ser Phe 
        35                  40                  45              


Ser Phe Phe Ala Asn Ala Lys Phe Thr Phe Lys Ala Ser Thr Thr Thr 
    50                  55                  60                  


Met Arg Tyr Met Leu Tyr Val Gly Phe Met Gly Thr Leu Ser Ala Thr 
65                  70                  75                  80  


Val Gly Trp Ala Ala Asp Arg Cys Ala Leu Pro Pro Met Ile Thr Leu 
                85                  90                  95      


Val Thr Phe Ser Ala Ile Ser Leu Val Cys Gly Phe Val Tyr Ser Lys 
            100                 105                 110         


Phe Ile Val Phe Arg Asp Ala Lys 
        115                 120 


<210>  8
<211>  306
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Lys Ile Ser Leu Val Val Pro Val Phe Asn Glu Glu Glu Ala Ile 
1               5                   10                  15      


Pro Ile Phe Tyr Lys Thr Val Arg Glu Phe Glu Glu Leu Lys Ser Tyr 
            20                  25                  30          


Glu Val Glu Ile Val Phe Ile Asn Asp Gly Ser Lys Asp Ala Thr Glu 
        35                  40                  45              


Ser Ile Ile Asn Ala Leu Ala Val Ser Asp Pro Leu Val Val Pro Leu 
    50                  55                  60                  


Ser Phe Thr Arg Asn Phe Gly Lys Glu Pro Ala Leu Phe Ala Gly Leu 
65                  70                  75                  80  


Asp His Ala Thr Gly Asp Ala Ile Ile Pro Ile Asp Val Asp Leu Gln 
                85                  90                  95      


Asp Pro Ile Glu Val Ile Pro His Leu Ile Glu Lys Trp Gln Ala Gly 
            100                 105                 110         


Ala Asp Met Val Leu Ala Lys Arg Ser Asp Arg Ser Thr Asp Gly Arg 
        115                 120                 125             


Leu Lys Arg Lys Thr Ala Glu Trp Phe Tyr Lys Leu His Asn Lys Ile 
    130                 135                 140                 


Ser Asn Pro Lys Ile Glu Glu Asn Val Gly Asp Phe Arg Leu Met Ser 
145                 150                 155                 160 


Arg Asp Val Val Glu Asn Ile Lys Leu Met Pro Glu Arg Asn Leu Phe 
                165                 170                 175     


Met Lys Gly Ile Leu Ser Trp Val Gly Gly Lys Thr Asp Ile Val Glu 
            180                 185                 190         


Tyr Val Arg Ala Glu Arg Ile Ala Gly Asp Thr Lys Phe Asn Gly Trp 
        195                 200                 205             


Lys Leu Trp Asn Leu Ala Leu Glu Gly Ile Thr Ser Phe Ser Thr Phe 
    210                 215                 220                 


Pro Leu Arg Ile Trp Thr Tyr Ile Gly Leu Val Val Ala Ser Val Ala 
225                 230                 235                 240 


Phe Ile Tyr Gly Ala Trp Met Ile Leu Asp Thr Ile Ile Phe Gly Asn 
                245                 250                 255     


Ala Val Arg Gly Tyr Pro Ser Leu Leu Val Ser Ile Leu Phe Leu Gly 
            260                 265                 270         


Gly Ile Gln Met Ile Gly Ile Gly Val Leu Gly Glu Tyr Ile Gly Arg 
        275                 280                 285             


Thr Tyr Ile Glu Thr Lys Lys Arg Pro Lys Tyr Ile Ile Lys Arg Val 
    290                 295                 300                 


Lys Lys 
305     


<210>  9
<211>  14440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example O4 rfb locus nucleotide sequence - O4-EPA production 
       strain BVEC-L-00684f

<400>  9
atgacgaatt taaaagcagt tattcctgta gcgggtctcg ggatgcatat gttgcctgcc       60

actaaggcga tacccaaaga gatgctacca atcgtcgaca agccaatgat tcagtacatt      120

gttgacgaga ttgtggctgc agggatcaaa gaaatcctcc tggtaactca cgcgtccaag      180

aacgcggtcg aaaaccactt cgacacctct tatgagttag aatcactcct tgagcagcgc      240

gtgaagcgtc aactgctggc ggaagtacag tccatctgtc cgccgggcgt gaccattatg      300

aacgtgcgtc agggcgaacc tttaggttta ggccactcca ttttgtgtgc gcgacctgcc      360

attggtgaca acccatttgt cgtggtactg ccagacgttg tgatcgacga tgccagcgcc      420

gacccgctac gttacaacct tgctgccatg attgcacgtt tcaacgaaac gggccgcagc      480

caggtgctgg caaaacgtat gccgggtgac ctctctgaat actccgtcat ccagactaaa      540

gagccgctgg accgtgaggg taaagtcagc cgcattgttg aatttatcga aaaaccggat      600

cagccgcaga cgctggactc agacatcatg gccgtaggtc gctatgtgct ttctgccgat      660

atttggccgg aactggaacg tactcagcct ggtgcatggg gacgtattca gctgactgat      720

gctattgccg agctggcgaa aaaacaatcc gttgatgcaa tgctgatgac cggcgacagt      780

tacgactgcg gcaaaaaaat gggctatatg caggcgtttg tgaagtatgg cctacgcaac      840

ctgaaagaag gggcgaagtt ccgtaaaggt attgagaagc tgttaagcga ataatgaaaa      900

tctgaccgga tgtaacggtt gataagaaaa ttataacggc agtgaaaatt cgcagcaaaa      960

gtaatttgtt gcgaatcttc ctgccgttgt tttatataaa ccatcagaat aacaacgagt     1020

tagcagtagg gttttattca aagttttcca ggattttcct tgtttccaga gcggattggt     1080

aagacaatta gcgtttgaat ttttcgggtt tagcgcgagt gggtaacgct cgtcacatca     1140

taggcatgca tgcagtgctc tggtagctgt aaagccaggg gcggtagcgt gcattaatac     1200

ctctattaat caaactgaga gccgcttatt tcacagcatg ctctgaagta atatggaata     1260

aattaagtga aaatacttgt tactggtggc gcaggattta ttggttcagc tgtagttcgt     1320

cacattataa ataatacgca ggatagtgtt gttaatgtcg ataaattaac gtacgccgga     1380

aaccgggaat cacttgctga tgtttctgat tctgaacgct atgtttttga acatgcggat     1440

atttgcgatg cacctgcaat ggcacggatt tttgctcagc atcagccgga tgcagtgatg     1500

cacctggctg ctgaaagcca tgttgaccgt tcaattacag gccctgcggc atttattgaa     1560

accaatattg ttggtactta tgtccttttg gaagccgctc gcaattactg gtctgctctt     1620

gatagcgaca agaaaaatag cttccgtttt catcatattt ctactgacga agtatatggt     1680

gatttgcctc atcctgacga ggtaaataat acagaagaat tacccttatt tactgagaca     1740

acagcttacg cgccaagcag cccttattcc gcatccaaag catccagcga tcatttagtc     1800

cgcgcgtgga aacgtaccta tggtttaccg accattgtga ctaattgctc taacaattat     1860

ggtccttatc atttcccgga aaaattgatt ccattggtta ttctcaatgc tctggaaggt     1920

aaagcattac ctatttatgg taaaggggat caaattcgcg actggctgta tgttgaagat     1980

catgcgcgtg cgttatatac cgtcgtaacc gaaggtaaag cgggtgaaac ttataacatt     2040

ggtgggcaca acgaaaagaa aaacatagat gtagtgctca ctatttgtga tttgctggat     2100

gagattgtac cgaaagagaa atcttatcgt gagcaaatca cttatgttgc cgatcgtccg     2160

ggacacgatc gccgttatgc gattgatgct gagaatattg gtcgcgaatt gggatggaaa     2220

ccacaggaaa cgtttgagag cgggattcgg aagacagtgg aatggtatct gtccaataca     2280

aaatgggttg ataatgtgaa aagtggtgcc tatcaatcgt ggattgaaga gaactatgag     2340

ggccgccagt aatgaatatc ctcctttttg gcaaaacagg gcaggtaggt tgggaactac     2400

agcgtgctct ggcacctctg ggtaacttga ttgctcttga tgttcattcc actgattatt     2460

gtggcgattt cagtaacccc gaaggtgtgg ctgaaaccgt caaaaaaatt cgcccagatg     2520

ttattgttaa tgctgctgct cataccgcgg tagataaggc tgagtcagaa ccagaatttg     2580

cacaattact caatgcgacc agcgttgaag caattgcaaa agcggctaat gaagttgggg     2640

cttgggtaat tcattactca actgactacg tcttccctgg aaatggcgac atgccatggc     2700

tcgagactga tgtaaccgct ccgctcaatg tttatggcaa aaccaaattg gctggagaaa     2760

gagcattaca agaacattgc gcaaagcatc ttattttccg taccagctgg gtatatgcag     2820

gtaaaggaaa taactttgcc aaaacaatgt tacgtctggc aaaagagcgc gaagaactgg     2880

ctgtgataaa cgatcagttt ggcgcaccaa caggtgctga attgctggct gattgcaccg     2940

ctcatgccat tcgcgtggca ttaaaaaaac cagaagttgc tggcttgtac catctggtag     3000

caaatggcac aacaacctgg cacgattacg ccgcgctagt attcgaagaa gcccgtaaag     3060

cagggattga ccttgcactt aacaaactca acgccgtacc aacaacggct tatcctactc     3120

cagcccgccg tcctcataat tctcgcctca ataccgaaaa gtttcagcag aactttgcgc     3180

ttgtcttgcc tgactggcag gtgggcgtga aacgtatgct caacgaatta tttacgacta     3240

cggcaattta acaaattttt gcatctcgct catgatgcca gagcgggatg aattaaaagg     3300

aatggtgaaa tgaaaacgcg taaaggtatt attctggctg gtggttccgg cactcgtctt     3360

tatcctgtga cgatggcagt gagtaaacaa ctgctgccga tttatgataa gccgatgatt     3420

tattatccgc tttcaacgct tatgttagcg ggtattcgcg atattcttat tatcagtacg     3480

ccacaggata caccgcgttt ccaacaattg ttgggggacg ggagtcagtg ggggcttaat     3540

ctacagtata aagtacaacc gagtccggat ggcctggcgc aagcgtttat tattggtgaa     3600

gactttattg gtggtgatga ttgtgcactc gtacttggcg ataatatctt ctatggacac     3660

gacttgccga aattaatgga agctgctgtt aacaaagaaa tcggtgcaac ggtatttgct     3720

tatcacgtca atgatcctga acgttatggt gtcgtggagt ttgataataa cggtactgca     3780

attagcctgg aagaaaaacc gctggaacca aaaagtaact atgcggttac tgggctttat     3840

ttctatgaca atgatgttgt agaaatggcg aaaaacctta agccttctgc ccgtggcgaa     3900

ctggaaatta ccgatattaa ccgtatttat atggagcagg gacgtttgtc tgtcgctatg     3960

atggggcgtg gttatgcctg gttggatact ggtacacatc aaagtcttat tgaagcaagt     4020

aacttcattg ccaccattga agagcgtcag ggattaaagg tatcttgccc ggaagagatt     4080

gcttaccgta aagggtttat tgatgctgag caggtgaaag tattagccga accgctgaag     4140

aaaaatgatt atggtcagta tctgctaaaa atgattaaag gttattaata aaatgaacgt     4200

aattaaaact gaaattcctg atgtgctgat ttttgaacca aaagtttttg gtgatgaacg     4260

tggcttcttt tttgagagtt ttaaccagaa agtatttgaa gaagctgtag gacggaaggt     4320

tgaatttgtt caggataacc attctaagtc taaaataaat gtattgcgtg ggatgcatta     4380

tcaaacacaa aatactcaag gaaaactggt tcgggtaatt tctggttcag tatatgatgt     4440

tgccgtagat ttaagagaaa aatcaaagac atttggcaaa tgggtgggtg tagaattatc     4500

tgggaataat aaaagacaat tgtggatccc cgaaggtttt gcccatggtt tttatgtgtt     4560

ggaggagaat accgaatttg tttataaatg taccgatact tataaccctg ctcatgaaca     4620

cacattgcta tggaatgatc caactatcaa tataagttgg ccaatcatac aaaactgcaa     4680

gccaattatt tctgaaaaag atgctaatgg acatcttttt tcacataaaa cctatttctg     4740

aaatgcaata ttatgagttt aattagaaac agtttctata atattgctgg ttttgctgtg     4800

ccgacattag ttgcagtccc tgctttgggg attcttgcca ggctgcttgg accggagaat     4860

tttggacttt tcacactagc attcgctttg ataggatatg caagtatttt cgacgccggg     4920

attagtcgag ctgtaatcag agaaatcgct ctttatcgag aaagtgaaaa agagcaaata     4980

caaattattt cgacagcaag tgtaatcgta ctattcttag gggtggttgc agctttgtta     5040

ctttatttta gtagtaataa agttgttgag ttattgaatg ttagttccgt ttatattgaa     5100

acagcagtgc gtgcattctc tgttatttca tttataatac ctgtgtatct gattaaccag     5160

atttggcttg gttatctgga agggctagaa aaatttgcaa atataaatgt tcagagaatg     5220

atttctagca caagcttggc tatattacca gtgatatttt gttattacaa tccctcgttg     5280

ctttatgcta tgtatgggtt ggtggttggg cgtgtgattt catttttgat tagcgcaata     5340

atttgtcgag atattattct taaaagtaaa ctttacttta atgtggcaac ttgcaatcgt     5400

cttatctctt ttggtggatg gataacagtt agtaatatca taagcccaat catggcatat     5460

ttcgaccgct ttatcatctc tcatattatg ggggcttcga gaattgcatt ttatacagcg     5520

ccctcagagg gtgtatcaag gttaattaat atcccatatg ctttggcaag agctctattt     5580

cctaaattgg catatagcaa taatgatgat gaacgaaaaa aattacaact acagagctac     5640

gcaattataa gcattgtatg tctacccata gttgttattg gtgtcatttt tgcctcattc     5700

ataatgacaa catggatggg acctgattat gccttagaag cagcaactat catgaaaata     5760

cttcttgctg gttttttctt taactcttta gcgcaaatac cttatgcata cttgcaatct     5820

atcggaaagt caaaaattac cgcatttgtg catctcatag aacttgcgcc atacttatta     5880

ttattgtatt acttcacaat gcatttcggc ataattggca cggcaatcgc ttggtcactt     5940

agaacatttt gtgattttgt tatactactt tcgatatcga gaagaaaatg attgcggttg     6000

atattgcgct tgcaacctac aatggtgcta attttattcg gcaacagatt gaatctatcc     6060

agaaacaaac ttatagaaat tggcgtctta taataagtga tgataactcg agtgatgata     6120

ctgttgatat tattaaggat atgatgtcta acgacagtcg tatctatttg gtaggaaata     6180

aaagacaagg aggggttatt cagaacttta attatgctct ttcacaaact acatctgaaa     6240

ttgtgttact atgtgaccag gatgacattt ggccggagga gcgtctggaa attcttatag     6300

ataaatttaa ggccttgcag cgtaatgatt ttgttccggc aatgatgttt actgatttga     6360

aattagtaga cgaaaataat tgtttgattg cagaaagttt ttatcgaacg aataatatta     6420

atccacaaga taatctgaaa aataataatc ttctctggcg ttcaacggta tatggctgta     6480

cttgcatcat gaataagaaa cttgttgata ttgcattgcc tatacctaca tatgcacata     6540

tgcatgatca atggttggca ttattagcga agcaatatgg taacattttt tatttcgact     6600

atgcgtctgt tcgttatagg caacattcta caaatgttgt tggtggtaga aataaaacgc     6660

catttcaaaa atttaattcc atacaaaaaa acctaaaaag gattaatttg ctagtggata     6720

gaactgttgc tttaattaaa tcaaataacg atttctatcc agggaataaa atggaaaata     6780

aaattgatta cttaaaattt ggagtgaatg aagtattacc ttatcttttt aaaggaaaca     6840

agaaagtttt ttcactttgt gtattaatta gtttggcatt acaaaaatga tatatttatt     6900

attttttttt gcactgttta tgatctgtac gtttttaaca cacaggcgac aggcattata     6960

tgttgtatct gcgttagtat ttcttttttt ggctttaacc tatccatcag gaggggactg     7020

gataggttat tttctccatt atgactgcat ggttaatgag cagtgtaata atggttttat     7080

aatgtttgaa cctggatatg aattaattgt ttccttattt ggatatttgg gatttcagac     7140

aattattatt tttatagccg ctgtaaatgt aattctaata ttaaattttg caaagcattt     7200

tgaaaacgga agttttgtta ttgttgcgat aatgtgcatg ttcctttgga gtgtttatgt     7260

tgaggcgatt agacaggctc tggccttatc tatagttata tttgggattc attctctttt     7320

tttgggtaga aaaaggaaat ttataacatt agtattattt gcgtcaactt tccatataac     7380

tgctttgatt tgttttcttc taatgactcc tctattttca aagaaattaa gcaagataat     7440

aagttatagc ctattaattt tcagtagctt ctttttcgct ttttctgaaa ccatattaag     7500

tgcactcctt gcaattttgc cagaaggatc cattgccagt gaaaaattaa gtttttactt     7560

agcaaccgag caatacaggc cacagttatc tattgggagt ggcactattc ttgacattat     7620

acttattttt ctgatatgtg taagttttaa acgaataaag aaatatatgc tcgctaatta     7680

taatgctgca aatgagatat tgcttattgg ttgctgtctt tatatttctt tcggtatttt     7740

tatcgggaaa atgatgccag ttatgactcg cattggttgg tatggttttc catttgttat     7800

agtacttctt tatattaact tgggttattc agaatatttt aagaggtata taaataaaag     7860

agggtgtggg tatagcaaat tattaattgc tttttatttt ttgctacaaa ttttgcgacc     7920

attaacatat gattatagct attataatat aatgcaccag gatactttgc tgaataggtt     7980

tgatgcatta gatgatgcat cattaagaca atcagcgaag agaaaatgtt tcgatttggg     8040

aaagatagga tatggtttct tatgtagtat ataatatcct gcattcattc ggataatttc     8100

ctatggaagt gtcctttgct ctgtctgtcc tcatttgttg aaattttatg ttaataagaa     8160

gctttagata accacttagg aactgtatgt ttgatctgtc caaaaattat attattgtaa     8220

gtgcgacggc gctggcttcc ggaggtgcat taactatatt aaagcaattt ataaaacatg     8280

catcacaaaa ttcaaatgac tatattatgt ttgtatctgc gggattggag ttgccggtct     8340

gtgataacat catttacata gaaaacacac caaaaggatg gttgaaaaga atatattggg     8400

attggttcgg ttgtcggaag tttatctcgg aacataagat taacgttaag aaagtaattt     8460

ctctacaaaa ttccagtttg aatgttcctt acgaacagat tatttacttg caccagccaa     8520

ttccttttag taaagttgat tcttttttaa aaaatatcac atccgataac gtaaagcttt     8580

ttttatataa aaagttttat tcctatttta tatttaaata tgtgaatgcc aatacaacca     8640

tcgtagtgca aacgaattgg atgaaaaaag gagtgctgga gcaatgtgat aaaattagta     8700

ccgaaagggt ccttgttata aaacctgata tcaaagcatt taataatact aattttgatg     8760

tagatatgga tgtatctgca aaaacactct tatatccagc gacaccactt acctataaaa     8820

atcatttggt cattctgaag gcgttggtta ttttaaagaa aaagtatttt atagatgatc     8880

tgaaattcca agtgactttt gaaaagaata ggtacaaaaa ttttgataag tttgtgcaat     8940

taaataactt aagcaaaaac gttgattatc tcggcgttct ttcatactcg aacttgcaaa     9000

aaaaatatat ggcggcatct ttaatcgttt ttcctagcta tatcgaatca tatgggttac     9060

cactcatcga agctgctagt ttaggaaaaa aaatcattag tagtgatctt ccttatgccc     9120

gggatgtttt aaaggattat agcggcgtag attttgtaat ttacaataat gaagatggct     9180

gggctaaggc gttgtttaat gttttaaatg gcaattcgaa gctcaatttt aggccttatg     9240

aaaaagatag tcgttcatct tggccacagt tcttctctat tttgaaataa ggtgtattat     9300

gtttaatggt aaaatattgt taattactgg tggtacgggg tctttcggta atgctgttct     9360

aagacgtttt cttgacactg atatcaaaga aatacgtatt ttttcccggg atgaaaaaaa     9420

acaagatgac atgaggaaaa aatataataa tccgaaactt aagttctata taggtgatgt     9480

tcgcgactat tcgagtatcc tcaatgcttc tcgaggtgtt gattttattt atcatgctgc     9540

agctctgaag caagtacctt cctgcgaatt ccacccaatg gaagctgtaa aaacgaatgt     9600

tttaggtacg gaaaacgtac tggaagcggc aatagctaat ggagttaggc gaattgtatg     9660

tttgagtaca gataaagctg tatatcctat caatgcaatg ggtatttcca aagcgatgat     9720

ggaaaaagta atggtagcaa aatcgcgcaa tgttgactgc tctaaaacgg ttatttgcgg     9780

tacacgttat ggcaatgtaa tggcatctcg tggttcagtt atcccattat ttgtcgatct     9840

gattaaatca ggtagaccaa tgacgataac agaccctaat atgactcgtt tcatgatgac     9900

tctcgaagac gctgttgatt tggttcttta cgcatttgaa catggcaata atggtgatat     9960

ttttgtccaa aaggcacctg cggctaccat cgaaacgttg gctattgcac tcaaagaatt    10020

acttaatgta aaccaacacc ctgtaaatat aatcggcacc cgacacgggg aaaaactgta    10080

cgaagcgtta ttgagccgag aggaaatgat tgcagcggag gatatgggtg attattatcg    10140

tgttccacca gatctccgcg atttgaacta tggaaaatat gtggaacatg gtgaccgtcg    10200

tatctcggaa gtggaagatt ataactctca taatactgat aggttagatg ttgagggaat    10260

gaaaaaatta ctgctaaaac ttccttttat ccgggcactt cggtctggtg aagattatga    10320

gttggattca taatatgaaa attttagtta ctggcgctgc agggtttatc ggtcgaaatt    10380

tggtattccg gcttaaggaa gctggatata acgaactcat tacgatagat cgtaactctt    10440

ctttggcgga tttagagcag ggacttaagc aggcagattt tatttttcac cttgctgggg    10500

taaatcgtcc cgtgaaggag tgtgaatttg aagagggaaa tagtaatcta actcaacaga    10560

ttgttgatat cctgaaaaaa aacaataaaa atactcctat catgctgagt tcttccatcc    10620

aggctgaatg tgataacgct tatggaaaga gtaaagcagc tgcggaaaaa atcattcagc    10680

agtatgggga aacgacaaac gctaaatatt atatttatcg cttgccgaat gtattcggta    10740

agtggtgtcg accaaattat aactccttta tagcaacttt ctgccatcgc attgcaaatg    10800

atgaagctat tacaattaat gatccttcag cagttgtaaa tctggtgtat atagatgact    10860

tttgttctga catattaaag ctattagaag gagcgaacga aactggttac aggacatttg    10920

gtccaattta ttctgttact gttggtgaag tggcacaatt aatttaccgg tttaaagaaa    10980

gtcgccaaac attaatcacc gaagatgtag gtaatggatt tacacgtgca ttgtactcaa    11040

catggttaag ttacctgtct cctgaacagt ttgcgtatac ggttccttct tatagtgatg    11100

acagaggggt attctgtgaa gtattgaaaa cgaaaaacgc gggccagttt tcgttcttta    11160

ctgcgcatcc aggaattact cggggtggtc attatcatca ttccaaaaat gagaaattta    11220

ttgtcatccg aggaagtgct tgtttcaaat ttgaaaatat tgtcacgagt gaacgatatg    11280

aacttaatgt ttcctctgat gattttaaaa ttgttgaaac agttccggga tggacgcata    11340

acattactaa taatggctcg gatgagctag ttgttatgct ttgggcaaat gaaatattta    11400

atcgttctga accagatact atagcgagag ttttatcgtg aaaaaattga aagtcatgtc    11460

ggttgttggg actcgtccag aaattattcg actctcgcgt gtccttgcaa aattagatga    11520

atattgtgac caccttattg ttcataccgg gcaaaactac gattatgaac tgaatgaagt    11580

ttttttcaaa gatttgggtg ttcgcaaacc tgattatttt cttaatgccg caggtaaaaa    11640

tgcagcagag actattggac aagttatcat taaagttgat gaggtccttg aacaggaaaa    11700

accagaagcc atgttagtac ttggcgatac taactcctgt atttcagcaa taccagcaaa    11760

gcgtcgaaga attccgatct tccatatgga ggctgggaat cgttgttttg accaacgcgt    11820

accggaagaa actaacagaa aaatagttga tcataccgct gatatcaata tgacatatag    11880

tgatatcgcg cgtgaatatc ttctggctga aggtgtacca gccgatagaa ttattaaaac    11940

cggtagccca atgtttgaag tactcactca ttatatgccg cagattgatg gttccgatgt    12000

actttctcgc ctgaatttaa cacctgggaa tttctttgtg gtaagtgccc acagagaaga    12060

aaatgttgat acccctaaac aacttgtgaa actggcgaat atacttaata ccgtggctga    12120

aaaatatgat gtcccggtag ttgtttctac tcatcctcgc actcgtaacc gcatcaacga    12180

aaacggtatt caattccata aaaatatctt gcttcttaag ccattaggat ttcacgatta    12240

caaccatctg caaaaaaatg cacgtgctgt tttatcggat agtgggacta ttacagaaga    12300

gtcctccatt atgaacttcc ctgcactcaa tatacgagaa gcgcacgaac gcccggaagg    12360

cttcgaagaa ggggcagtaa tgatggtcgg tcttgaatct gatcgcgttt tacaggcatt    12420

agaaattatt gcaacacagc ctcgtggaga agtacgctta cttcgtcagg ttagtgacta    12480

tagcatgcca aatgtttcag ataaagttct gcgtattatc cattcatata ctgactacgt    12540

taaacgggtt gtctggaagc aatactaatg aaacttgcat taatcattga tgattatttg    12600

ccccatagca cacgcgttgg ggctaaaatg tttcatgagt taggccttga attactgagc    12660

agaggccatg atgtaactgt aattacgcct gacatctcat tacaagcaat ttattctatt    12720

agtatgattg atggtataaa ggtttggcgt ttcaaaagtg gacctttaaa ggatgtaggt    12780

aaggctaaac gtgccataaa tgaaactctt ttatcttttc gcgcatggcg cgcatttaag    12840

cacctcattc aacatgatac atttgatggt atcgtttatt attccccctc tattttttgg    12900

ggcgacttgg ttaaaaaaat aaaacaacga tgccagtgcc caagctatct gatcctaagg    12960

gatatgtttc cacagtgggt cattgatgca ggtatgttga aagccggttc accaattgaa    13020

aaatatttta ggtattttga aaaaaagtca tatcagcagg ctggccggat aggggtaatg    13080

tctgataaga atcttgagat atttcgccag accaataaag gttatccgtg tgaagtttta    13140

cgtaattggg cctcaatgac tcctgtgtct gccagcgatg attatcattc acttcgtcaa    13200

aaatacgatc taaaagataa agtcattttt ttctatggcg gtaatattgg gcatgctcag    13260

gatatggcaa acttaatgcg ccttgcgcgt aatatgatgc gttatcatga tgctcatttc    13320

ctgtttatag ggcagggtga tgaagttgag ctgataaaat ctcttgctgc agaatggaat    13380

ttaactaatt tcactcatct accttcagtg aaccaggaag agtttaaatt aattttatct    13440

gaagttgatg tcggcctgtt ctccctttca tctcgccatt cttcacataa tttccccgga    13500

aaattactag ggtatatggt tcaatcaatc ccgatccttg ggagtgtgaa tggcggcaat    13560

gatttaatgg atgtaattaa taagcacaga gccggtttca ttcatgttaa tggtgaagat    13620

gataaactgt ttgaatctgc acaattgctt cttagtgatt cagttttaag aaaacagcta    13680

ggtcagaacg ctaatgtgtt gttaaagtct caattttcgg ttgaatcggc ggcacatact    13740

atcgaagtcc gactggaggc tggagaatgc gtttagttga tgacaatatt ctggatgaac    13800

tttttcgcac tgcagcaaat tctgaacgtt tgcgcgctca ttatttattg cacgcatctc    13860

atcaggagaa ggttcaacgt ttacttattg catttgtacg cgacagctat gttgaacccc    13920

attggcatga gttaccgcat cagtgggaaa tgtttgtcgt catgcaaggg caattagaag    13980

tttgtttgta tgagcaaaat ggtgagatcc aaaaacagtt tgttgttgga gacggtacgg    14040

gaataagcgt cgtggaattt tccccaggag atatacatag tgtcaaatgc ctgtcaccaa    14100

aagcccttat gttggagata aaggaggggc catttgaccc actcaaagct aaggcttttt    14160

ctaagtggtt atagggcgat acaccaccgt ttattcttct atcttattct atacatgctg    14220

ggttaccatc ttagcttctt caagccgcgc aaccccgcgg tgaccacccc tgacaggagt    14280

agctagcatt tgaccacccc tgacaggatt agctagcata tgagctcgag gatatctact    14340

gtgggtaccc gggatccgtg taggctggag ctgcttcgaa gttcctatac tttctagaga    14400

ataggaactt cggaatagga actaaggagg atattcatat                          14440


<210>  10
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  example signal sequence for EPA carrier protein

<400>  10

Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala 
            


<210>  11
<211>  13043
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example O1A rfb locus nucleotide sequence - O1A-EPA production 
       strain stGVXN4411 and stLMTB10217

<400>  11
atgacgaatt taaaagcagt tattcctgta gcgggtctcg ggatgcatat gttgcctgcc       60

actaaggcga tacccaaaga gatgctacca atcgtcgaca agccaatgat tcagtacatt      120

gttgacgaga ttgtggctgc agggatcaaa gaaatcctcc tggtaactca cgcgtccaag      180

aacgcggtcg aaaaccactt cgacacctct tatgagttag aatcactcct tgagcagcgc      240

gtgaagcgtc aactgctggc ggaagtacag tccatctgtc cgccgggcgt gaccattatg      300

aacgtgcgtc agggcgaacc tttaggttta ggccactcca ttttgtgtgc gcgacctgcc      360

attggtgaca acccatttgt cgtggtactg ccagacgttg tgatcgacga tgccagcgcc      420

gacccgctac gttacaacct tgctgccatg attgcacgtt tcaacgaaac gggccgcagc      480

caggtgctgg caaaacgtat gccgggtgac ctctctgaat actccgtcat ccagactaaa      540

gagccgctgg accgtgaggg taaagtcagc cgcattgttg aatttatcga aaaaccggat      600

cagccgcaga cgctggactc agacatcatg gccgtaggtc gctatgtgct ttctgccgat      660

atttggccgg aactggaacg tactcagcct ggtgcatggg gacgtattca gctgactgat      720

gctattgccg agctggcgaa aaaacaatcc gttgatgcaa tgctgatgac cggcgacagt      780

tacgactgcg gcaaaaaaat gggctatatg caggcgtttg tgaagtatgg cctacgcaac      840

ctgaaagaag gggcgaagtt ccgtaaaggt attgagaagc tgttaagcga ataatgaaaa      900

tctgaccgga tgtaacggtt gataagaaaa ttataacggc agtgaaaatt cgcagcaaaa      960

gtaatttgtt gcgaatcttc ctgccgttgt tttatataaa ccatcagaat aacaacgagt     1020

tagcagtagg gttttattca aagttttcca ggattttcct tgtttccaga gcggattggt     1080

aagacaatta gcgtttgaat ttttcgggtt tagcgcgagt gggtaacgct cgtcacatca     1140

taggcatgca tgcagtgctc tggtagctgt aaagccaggg gcggtagcgt gcattaatac     1200

ctctattaat caaactgaga gccgcttatt tcacagcatg ctctgaagta atatggaata     1260

aattaagcta gcgtgaagat acttgttact aggggcgcag gatttattgg ttctgctgta     1320

gttcgtcaca ttataaataa tacgcaggat agtgttgtta atgtcgataa attaacgtac     1380

gccggaaacc tggaatcact tgctgatgtt tctgactctg aacgctatgt ttttgaacat     1440

gcggatattt gcgatgctgc tgcaatggcg cggatttttg ctcagcatca gccggatgca     1500

gtgatgcacc tggctgctga aagccatgtg gatcgttcaa ttacaggccc tgcggcattt     1560

attgaaacca atattgttgg tacttatgtc cttttggaag cggctcgcaa ttactggtct     1620

gctcttgatg gcgacaagaa aaatagcttc cgttttcatc atatttctac tgacgaagtc     1680

tatggtgatt tgcctcatcc tgacgaagta aataataaag aacaattacc cctctttact     1740

gagacgacag cttacgcgcc tagtagtcct tattccgcat caaaagcatc cagcgatcat     1800

ttagtccgcg cgtggaaacg tacctatggt ttaccgacta ttgtgactaa ctgttcgaat     1860

aactacggtc cttatcactt tccggaaaaa ttgattccac tagtaattct taatgctctg     1920

gaaggtaagg cattacctat ttatggcaaa ggggatcaaa ttcgtgactg gctgtatgtt     1980

gaagatcatg cgcgtgcgtt atataccgta gttactgaag gtcaagcggg tgaaacctat     2040

aacattggcg gacacaacga aaagaaaaac atcgatgttg tgctgactat ttgtgatttg     2100

ttggacgaga tagtcccgaa agagaaatct tatcgtgagc aaattactta tgttgctgat     2160

cgcccagggc atgatcgccg ttatgcgatt gatgctgaga agattggtcg cgaattggga     2220

tggaaaccac aggaaacgtt tgagagtggg attcgtaaaa cggtggaatg gtatttggct     2280

aatgcaaaat gggttgataa tgtgaaaagt ggtgcctatc aatcgtggat tgaacagaac     2340

tatgagggcc gccagtaatg aatatcctcc tttttggcaa aacagggcag gtaggttggg     2400

aactacagcg tgctctggca cctctgggta atttgattgc tcttgatgtt cactccactg     2460

attactgtgg tgattttagt aaccctgaag gtgtggctga aacagtcaaa agaattcgac     2520

ctgatgttat tgttaatgct gcggctcaca ccgcagtaga taaggctgag tcagaacccg     2580

aatttgcaca attactcaat gcgactagcg ttgaatcaat tgcaaaagcg gcaaatgaag     2640

ttggggcttg ggtaattcat tactcaactg actacgtatt ccctggaaat ggcgacacgc     2700

catggctgga gatggatgca accgcaccgc taaatgttta cggtgaaacc aagttagctg     2760

gagaaaaagc attacaagag cattgtgcga agcacctaat tttccgtacc agctgggtct     2820

atgcaggtaa aggaaataat ttcgccaaaa cgatgttgcg tctggcaaaa gagcgtgaag     2880

aactagccgt tattaatgat cagtttggtg cgccaacagg tgctgaactg ctggctgatt     2940

gtacggcaca tgccattcgt gtcgcactga ataaaccgga tgtcgcaggc ttgtaccatt     3000

tggtagccag tggtaccaca acctggtacg attatgctgc gctggttttt gaagaggcgc     3060

gcaatgcagg cattcctctt gcactcaaca agctcaacgc agtaccaaca actgcctatc     3120

ctacaccagc tcgtcgtcca cataactctc gccttaatac agaaaaattt cagcagaatt     3180

ttgcgcttgt attgcctgac tggcaggttg gtgtgaaacg catgctcaac gaattattta     3240

cgactacagc aatttaatag tttttgcatc ttgttcgtga tggtggagca agatgaatta     3300

aaaggaatga tgaaatgaaa acgcgtaaag gtattatttt agcgggtggt tctggtactc     3360

gtctttatcc tgtgactatg gtcgtcagta aacagctatt acctatatat gataaaccga     3420

tgatctatta tccgctttct acactgatgt tagcgggtat tcgcgatatt ctgattatta     3480

gtacgccaca ggatactcct cgttttcaac aactgctggg tgacggtagc cagtggggcc     3540

tgaatcttca gtacaaagtg caaccgagtc cggatggtct tgcgcaggca tttattatcg     3600

gtgaagagtt tattggtggt gatgattgtg ctttggtact tggtgataat atcttctacg     3660

gtcacgacct gcctaagtta atggatgccg ctgttaacaa agaaagtggt gcaacggtat     3720

ttgcctatca cgttaatgat cctgaacgct atggtgtcgt tgagtttgat aaaaacggta     3780

cggcgatcag cctggaagaa aaaccgctac aaccaaaaag taattatgcg gtaaccgggc     3840

tttattttta tgataacgac gttgtcgaaa tggcgaaaaa tcttaagcct tctgcccgcg     3900

gtgaactgga aattaccgat attaaccgta tctatatgga acaagggcgt ttatctgttg     3960

ccatgatggg gcgtggttat gcgtggttag acacggggac acatcagagc ctgattgagg     4020

caagcaactt tattgcaaca attgaagagc gtcaggggct gaaagtttcc tgcccggaag     4080

aaattgctta ccgtaaaggg tttgttgatg ctgagcaggt gaaagtatta gctgaacctc     4140

tgaaaaaaaa tgcttatggt cagtatctgc tgaaaatgat taaaggttat taataaaatg     4200

aacgtaatta aaacagaaat tcctgatgta ctgatttttg aaccgaaagt ttttggtgat     4260

gagcgtggtt tcttttttga gagctttaac cagaaggttt ttgaggaagc tgtaggccgc     4320

aaagttgaat ttgttcagga taaccattcg aagtctagta aaggtgtttt acgcgggctg     4380

cattatcagt tggaacctta tgcacaagga aaattggtgc gttgcgttgt cggtgaagtt     4440

tttgacgtag ctgttgatat tcgtaaatcg tcatcgactt ttggcaaatg ggttggggtg     4500

aatttatctg ctgagaataa gcggcaattg tggattcctg agggatttgc acatggtttt     4560

ttagtgctga gtgagacggc ggagtttttg tataagacga caaattatta tcatcctcag     4620

agtgatagag gaataaaatg ggatgatcca agcatcaata tttcatggcc agtcgattca     4680

caagtgctgc tatcagctaa agataataag catcctccat taacaaagat tgaaatgtat     4740

agttaagatc acgataaatc ttggaagggt tgcaaaattg aataaaatag tgagcaaaag     4800

tgaaataagg aacgtaatcc acaatgctgg ctatatgatg attactcaga tagctttata     4860

tgttgcacca ttatttatac tgagttatct gttaaaaaca ctgggggttg cacagtttgg     4920

taattatgcc ttaatactat caatcgttgc atatttacag attataacgg attatggttt     4980

ttcttttagt gcaagtcgtg cgatctcaca gaatagagag gacaaagaat atatatcaaa     5040

aatttatctg tcaactatga ctatcaagtt ggcgatatgc gctttcttat tcttattgct     5100

catgctattt ttaaatcttt tgcctgtgca agctgaatta aaacaaggaa tattatatgg     5160

atatcttctt gtaataggaa atactttcca accacaatgg tttttccaag gtatcgaaaa     5220

attaaaaatc atagcccttt ctaatgttat atcaagatgc gccgcgtgtt tacttgtatt     5280

tatctatgtg aggaatagcg aggatttaca aaaagcactt ttagtacagt cacttccatt     5340

agtaatttct gcgattggat taaatatatt tatattgaaa tatatcaata ttatttttcc     5400

ggaaaaaaaa ttatttaagg taattttaaa agaaggtaag gatttttttc ttgcatcact     5460

ttattctgtt attctcaata atagtggcat ttttctatta gggattttta ctaatcctgt     5520

tattgttggt gtatatgccg ccgctgaaaa gatagtcaag gccgtattgt cgctatttac     5580

accactgacg caagctatat atccttataa ttgtcgtaag ttttcactat ccgtatttga     5640

cggcattgag gcagcaaaaa aaactggtat accaattata attttagcat ttatagctgc     5700

tgttatcgtt gcaattacct tacctgttgc aatcgactat cttaattttc caaaagaaac     5760

aatttttgta ggtcaaatat taagtgcatg gatctttttt ggtgttctta ataatgtatt     5820

cggcattcag atattgagtg catcaggaag aagtaaaata tatagtagga tggtattcgt     5880

atcagcgctt ataacattac ttttgattac tctattattg cagttttgta acgccactgg     5940

agtggcatgt gcaatattat tgggtgaaat gttcttatca atattgttac ttaagcgata     6000

taaaaaaata atttaaggaa tagttatgaa gaagttatta ttagtgttcg gtactaggcc     6060

tgaagcaata aagatggcct ctatcattga attattaaaa aaagattgta gattcgaata     6120

taaaatatgt gtgacaggcc aacataaaga gatgcttgat caagttatgc aagtatttga     6180

tgttaaacct gattataatt tacggattat gcagcctggg caaacattag tatctatagc     6240

aacaaatata ctctcacggt taagtgaagt tttaattata gaaaagccag atattatact     6300

tgtgcatggg gatacaacga ctacccttgc tgctacttta gctgggtatt accaccaaat     6360

aaaagtttgt catgtggaag caggattaag aacaggggat atttactctc cttggcctga     6420

agagggcaat cgtaaagtta caggggcatt agcatgtatt catttcgccc caacagagag     6480

atcaaaagat aatctcctga gggagggggt caaagtaaat aatatatttg taacgggtaa     6540

taccgtcatc gactctttat ttattgcaaa agatatcata gataatgacc ctaatataaa     6600

gaacgcttta cataataaat ttaattttct tgataaaagc cgacgagtag tacttataac     6660

aggtcatcga agagaaaatt tcgggaaagg ttttgaagat atatgctttg caataaagga     6720

attagctttc atttatccta atgtagattt tatttatccg gtgcatctta atcccaatgt     6780

aatggaacca gtacatcgta tattagataa tatatgtaat atttacctta ttgagccctt     6840

ggattatttg ccttttgttt atttaatgaa tgagtcatat ttaatattga ctgattcagg     6900

ggggatacaa gaagaagcgc cttcgttagg taaaccggtt ttggttatgc gtgatactac     6960

tgaacgccct gaggcggttg aggctggtac tgttgtatta gtggggactt ctaagataaa     7020

aatagtaaat aaagtaacgg agctattaaa caatgctgat atctacaatg ctatgtctct     7080

gttacataat ccatatggcg atggaacagc tgctcaaaaa attcttaatg tgctcgccca     7140

agagctaatt taatttaagc taaaaatatg ttattaatta ttgctgatta tccaaacgaa     7200

atgaatatgc gcgagggagc tatgcaacga atagatgcga tagactctct cattcgagat     7260

cgcaagcgag tgtatttgaa tatttcattc aaaaagcatc tagttcgctc aaatagttcc     7320

tttaataatg ttatagttga aaatctaaat gcaattattc acagaaacat cataaaacag     7380

tacatgcaaa aatcaacaac tatatatgtt cattctgttt ataatttatt aaaggttata     7440

acgctcattg atctaaaaaa aacaattctt gatatacatg gtgttgtacc ggaagaactt     7500

ttggcagata ataaaaaatt acttagtaaa gtatataaca tggtggaaaa aaaaggtgtc     7560

cttggatgca aaaaattaat acacgtcagt acagaaatgc aaaaacacta tgaagcaaaa     7620

tatggagtaa acttggctga aaggtcaata gtgctcccga tttttgaata taaaaatata     7680

acccaatcgc aaaacaaatg gacagaaaat aaaatacgaa gtatctatct tggaggatta     7740

caaacatggc aaaatattga taaaatgatt caagtttgtg atgacacagt gataaacaat     7800

gaagcaggta agtatgaatt caactttttc atcccacaga gtaacttgga agggtttata     7860

gataaatatt cgttaaaatt acataatatc aatgctaatg catctacgct atcacgtgat     7920

gaagtaattc cctttctaaa agaatgtcat attggttttg tattgcgcga tgatataata     7980

gtaaacagag ttgcgtgccc tacaaaattg gttgaatatt tagagtgtgg tgtcgttcca     8040

gttgtgctct ccccacttat aggtgatttt tattcgatgg gatatcaata cattactaca     8100

gaggaaatgg ctaacagaag tataagtttg ttggatcttg aaaaaatggc tgcacataat     8160

ttacaaattt tgacttctta tcagaagaga acctacaagg cacagaaaga acttattgct     8220

caactgtgct gaatttttta catatataaa attatgtaag catatcgcgg gtcaggtaat     8280

tgtatgcgta tcaaatataa agataacggt tatatattat gttttctatt atgtttcatt     8340

ttgagctact tagttttact caaatctgac tactttcctg ctgattttct gccatataca     8400

gaaatatacg atgggacata cggagaaatc aataatattg agcctgcctt tttatattta     8460

acacggttgt ttcattattt aaatttcccc tatatatttt ttgcaatgtt agtttgtgcc     8520

ttatgtttaa gttggaaaat aaaatatgca agaaaaataa ttaaagatag ttatatatat     8580

ttgttcttgt atgtatatgt atcattttat gtgtttttgc atgaaatgac tcaattgcgc     8640

atagcaattg cagtcactat gtgctatgtg tcggtttatt attactttta taaaaattgt     8700

attaaacatg cactgccatg gatggtgttg gctattttgt ttcattacag cgccttgctt     8760

ttatttatgt cattatttat atacagttat aggaggttat taatagtaat tatagggttt     8820

gtaatatgta tgagcttttt aaacgtgtat gcagatacaa ttgcactata tttgccaaat     8880

gaaaaaatag taaattattt atatagtatt tcatcatcat tagacaatag aaatgatttg     8940

gcaatattca acctgaataa tataatattt ttatcaatat ttattttgat cttttatctt     9000

agccgatata taaaattaaa tgataatgag gcgaagttta ttaagtatgt gcaatgttca     9060

ggaatattag ccttttgtat tttctttctg gctagtggag tcccggtcat tgcttatcga     9120

actgcagagt tgctgcgaat attttatccg atggctttag tattaatcct ttcgcatata     9180

aaaaataata atatgcgtta ttttattgca gtcattatag ttatcctttc aggcttaatg     9240

ttgtttataa cactaagggc tgtatcaata gttggtcaag gattataaaa tgaatgttgc     9300

tattttgttg tctacgtata atggcgaaaa atatttagag gaacaactgg attcattgct     9360

gcttcaaagt tatcaggatt ttgtagtgta tatccgtgat gacggatcat ctgatagaac     9420

tgtaaatata ataaaccaat acgtaatgaa agataacaga tttattaacg tgggtaattc     9480

agaaaatctt ggttgtgctg cttcgtttat taatttatta agaaatgctt cagccgatat     9540

ttatatgttt tgtgaccaag atgattattg gcttccgaat aaattacagc gtgctgtgga     9600

ttatttttcg gctattgatc ctttacaacc taccttgtat cattgcgatc taagcgttgt     9660

tgatgaaaaa cttaatatta tacaaaattc atttttgcag catcagaaaa tgtcagcgta     9720

tgattcaatg agaaaaaata atcttttcat acaaaatttt gttgttggtt gttcatgtgc     9780

tgttaatgct tcacttgcgg aatttgttct ttcgcgaatt ggagagcagc atgtaaaaat     9840

gatagctatg catgactggt ggttagccgt gactgcaaaa ctttttggtc gaatccattt     9900

tgataatact caaacgattc tttatcgaca acatcagggc aatgtattag gtgcaaaatc     9960

atcaggtatg atgcgtttta ttcgattagg attaaatggg caagggattt cgcgagtagt    10020

atcttttaga aaaaaagttt gtgcgcaaaa taagcttctt ttagatgtct atgataaaga    10080

tttaaatctt gagcaaaaaa aatctatcag gcttgtaatt gagggcctta aagagaactc    10140

ttcaattgct gaccttttaa aatgtttcta tcatggtagc tatatgcaag gttttaaacg    10200

taatcttgcc ttaatatatt cagttcttta cacaaaaaaa agaagatagt gtatccttat    10260

gaaaaaaatt gctattatcg gtactgttgg cataccagca tcatatggcg gatttgaaac    10320

attagttgaa aatttaacaa gatacaattc ctcgggagtt gaatataatg ttttttgttc    10380

atcgtttcac tacaaatccc accaaaaaaa acataatggg gcccgtttaa tttatattcc    10440

gcttaaagcc aatggatggc agagcattgc gtatgacata atttcgttag catattctat    10500

ttttttgaag cctgatgtga ttctgatttt aggggtttct ggttgttcat ttttgccttt    10560

cttcaaactc ttaacacgcg ctaagtttat tactaatatt gatggcctgg aatggcgaag    10620

agataaatgg aattcaaaag tgaaacgttt cttaaaattt tcagaaaaaa tcgcagttca    10680

atattcggat gtcgttatta cggataatga ggcaatttct gagtacgttt ttaacgagta    10740

taataaagat agccgagtta ttgcctatgg aggggatcat gcatggttaa atactgagga    10800

tgtatttaca acaagaaatt ataaaagcga ttactacctt tctgtatgtc gtatcgaacc    10860

cgaaaacaat gtagaattaa ttttaaaaac attttcaaag ctaaaatata aaataaaatt    10920

tattggaaat tggaatggca gcgagtttgg aaagaaactt aggctgcatt attctaacta    10980

tccaaatatt gaaatgattg atccgattta tgatcttcaa caattatttc acttacgaaa    11040

taattgcata ggatatatac atggtcattc ggctggagga acaaaccctt ctttagtcga    11100

ggcaatgcat tttagtaaac ctatatttgc atatgattgt aagtttaata ggtacactac    11160

tgaaaatgaa gcatgttatt tttctaatga atctgacctc gcagagaaaa tcataatgca    11220

ttgtgagcta tcattaggtg tctctggcac gaaaatgaaa gaaattgcta accagaaata    11280

cacttggaga cgaatagcag aaatgtatga ggattgctat taactctgtt aaacttcaaa    11340

tcttttacaa tatatggcat gactataagc gcattaattg tttttcaagc cgctctcgcg    11400

gtgaccaccc cctgacaggg gatccgtgta ggctggagct gcttcgaagt tcctatactt    11460

tctagagaat aggaacttcg gaataggaac taaggaggat attcatatgg ataaagccgt    11520

aagcatataa gcatggataa gctatttata ctttaataag tactttgtat acttatttgc    11580

gaacattcca ggccgcgagc attcagcgcg gtgatcacac ctgacaggag tatgtaatgt    11640

ccaagcaaca gatcggcgta gtcggtatgg cagtgatggg acgcaacctt gcgctcaaca    11700

tcgaaagccg tggttatacc gtctctattt tcaaccgttc ccgtgagaag acggaagaag    11760

tgattgccga aaatccaggc aagaaactgg ttccttacta tacggtgaaa gagtttgtcg    11820

aatctctgga aacgcctcgt cgcatcctgt taatggtgaa agcaggtgca ggcacggatg    11880

ctgctattga ttccctcaaa ccatatctcg ataaaggaga catcatcatt gatggtggta    11940

acaccttctt ccaggacact attcgtcgta atcgtgagct ttcagcagag ggctttaact    12000

tcatcggtac cggtgtttct ggcggtgaag agggggcgct gaaaggtcct tctattatgc    12060

ctggtggcca gaaagaagcc tatgaattgg tagcaccgat cctgaccaaa atcgccgccg    12120

tagctgaaga cggtgaacca tgcgttacct atattggtgc cgatggcgca ggtcactatg    12180

tgaagatggt tcacaacggt attgaatacg gcgatatgca gctgattgct gaagcctatt    12240

ctctgcttaa aggtggcctg aacctcacca acgaagaact ggcgcagacc tttaccgagt    12300

ggaataacgg tgaactgagc agttacctga tcgacatcac caaagatatc ttcaccaaaa    12360

aagatgaaga cggtaactac ctggttgatg tgatcctgga tgaagcggct aacaaaggta    12420

ccggtaaatg gaccagccag agcgcgctgg atctcggcga accgctgtcg ctgattaccg    12480

agtctgtgtt tgcacgttat atctcttctc tgaaagatca gcgtgttgcc gcatctaaag    12540

ttctctctgg tccgcaagca cagccagcag gcgacaaggc tgagttcatc gaaaaagttc    12600

gtcgtgcgct gtatctgggc aaaatcgttt cttacgccca gggcttctct cagctgcgtg    12660

ctgcgtctga agagtacaac tgggatctga actacggcga aatcgcgaag attttccgtg    12720

ctggctgcat catccgtgcg cagttcctgc agaaaatcac cgatgcttat gccgaaaatc    12780

cacagatcgc taacctgttg ctggctccgt acttcaagca aattgccgat gactaccagc    12840

aggcgctgcg tgatgtcgtt gcttatgcag tacagaacgg tattccggtt ccgaccttct    12900

ccgcagcggt tgcctattac gacagctacc gtgctgctgt tctgcctgcg aacctgatcc    12960

aggcacagcg tgactatttt ggtgcgcata cttataagcg tatcgataaa gaaggtgtgt    13020

tccataccga atggctggat taa                                            13043


<210>  12
<211>  13790
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example O2 rfb locus nucleotide sequence - O2-EPA production 
       strain stGVXN4906

<400>  12
atgacgaatt taaaagcagt tattcctgta gcgggtctcg ggatgcatat gttgcctgcc       60

actaaggcga tacccaaaga gatgctacca atcgtcgaca agccaatgat tcagtacatt      120

gttgacgaga ttgtggctgc agggatcaaa gaaatcctcc tggtaactca cgcgtccaag      180

aacgcggtcg aaaaccactt cgacacctct tatgagttag aatcactcct tgagcagcgc      240

gtgaagcgtc aactgctggc ggaagtacag tccatctgtc cgccgggcgt gaccattatg      300

aacgtgcgtc agggcgaacc tttaggttta ggccactcca ttttgtgtgc gcgacctgcc      360

attggtgaca acccatttgt cgtggtactg ccagacgttg tgatcgacga tgccagcgcc      420

gacccgctac gttacaacct tgctgccatg attgcacgtt tcaacgaaac gggccgcagc      480

caggtgctgg caaaacgtat gccgggtgac ctctctgaat actccgtcat ccagactaaa      540

gagccgctgg accgtgaggg taaagtcagc cgcattgttg aatttatcga aaaaccggat      600

cagccgcaga cgctggactc agacatcatg gccgtaggtc gctatgtgct ttctgccgat      660

atttggccgg aactggaacg tactcagcct ggtgcatggg gacgtattca gctgactgat      720

gctattgccg agctggcgaa aaaacaatcc gttgatgcaa tgctgatgac cggcgacagt      780

tacgactgcg gcaaaaaaat gggctatatg caggcgtttg tgaagtatgg cctacgcaac      840

ctgaaagaag gggcgaagtt ccgtaaaggt attgagaagc tgttaagcga ataatgaaaa      900

tctgaccgga tgtaacggtt gataagaaaa ttataacggc agtgaaaatt cgcagcaaaa      960

gtaatttgtt gcgaatcttc ctgccgttgt tttatataaa ccatcagaat aacaacgagt     1020

tagcagtagg gttttattca aagttttcca ggattttcct tgtttccaga gcggattggt     1080

aagacaatta gcgtttgaat ttttcgggtt tagcgcgagt gggtaacgct cgtcacatca     1140

taggcatgca tgcagtgctc tggtagctgt aaagccaggg gcggtagcgt gcattaatac     1200

ctctattaat caaactgaga gccgcttatt tcacagcatg ctctgaagta atatggaata     1260

aattaagtga aaatacttgt tactggtggc gcaggattta ttggttcagc tgtagttcgt     1320

cacattataa ataatacgca ggatagtgtt gttaatgtcg ataaattaac gtacgccgga     1380

aaccgggaat cacttgctga tgtttctgat tctgaacgct atgtttttga acatgcggat     1440

atttgcgatg cacctgcaat ggcacggatt tttgctcagc atcagccgga tgcagtgatg     1500

cacctggctg ctgaaagcca tgttgaccgt tcaattacag gccctgcggc atttattgaa     1560

accaatattg ttggtactta tgtccttttg gaagccgctc gcaattactg gtctgctctt     1620

gatagcgaca agaaaaatag cttccgtttt catcatattt ctactgacga agtctatggt     1680

gatttgcctc atccagatga agtaaataat acagaagaat tacccttatt tactgagacg     1740

acagcttacg cgccaagcag cccttattcc gcatccaaag catccagcga tcatttagtc     1800

cgcgcatgga aacgtacgta tggtttaccg accattgtga ctaattgctc gaacaactat     1860

ggtccgtatc acttcccgga aaagcttatt ccattggtta ttcttaatgc actggaaggt     1920

aaggcattac ctatttatgg caaaggggat caaattcgcg actggttgta tgtagaggat     1980

catgctcgtg cgttatatac cgtcgtaacc gaaggtaaag cgggtgaaac ttataacatt     2040

ggcggacaca acgaaaagaa aaacatcgat gttgtgctga ctatttgtga tttgttggat     2100

gagattgtac cgaaagagaa atcttatcgt gagcaaatta cttatgttgc tgatcgccca     2160

gggcatgatc gccgttatgc aattgatgcc gataaaatta gccgcgaatt gggctggaaa     2220

ccacaggaaa cgtttgagag cgggattcgc aaaacggtgg aatggtatct ggctaataca     2280

aattgggttg agaatgtgaa aagcggtgct tatcagtcat ggatcgaaca aaactatgag     2340

ggccgtcagt aatgaatatc ctgcttttcg gcaaaacagg gcaggtgggt tgggaactgc     2400

agcgtgctct ggcgccgctg ggtaatctga tcgctcttga tgttcactcc actaattatt     2460

gtggagattt cagcaacccc gaaggtgtgg cagaaaccgt caaaaaaatt cgtcctgacg     2520

ttattgttaa tgctgctgct cacactgcag tagataaagc agaatcagaa ccggatttcg     2580

cacaattact taacgcgaca agcgtcgaag cgattgcaaa agctgctaat gaagtcgggg     2640

cctgggttat acactactct actgattatg ttttcccagg cagtggtgac gcgccatggc     2700

tggaaacgga tgcaacagca ccgctaaatg tttacggtga aacaaaatta gctggggaaa     2760

aggcattaca agaacattgc gcaaagcatc ttattttccg taccagctgg gtatacgctg     2820

gtaaaggaaa taactttgct aaaacgatgt tgcgtttggc aaaagaacgc gaagaactgg     2880

ctgtgataaa cgatcagttt ggcgcaccaa caggtgctga attgctggct gattgcaccg     2940

ctcatgccat tcgcgtggca ttaaaaaaac cagaagtcgc tggcttgtac catctggtag     3000

caagtggcac aacaacctgg cacgattatg ctgcgctggt ttttgaagag gcgcgcaaag     3060

cagggattaa tcttgcactt aacaaactta acgccgtgcc aacaacggcc tatcccacac     3120

cagcccgtcg accccataac tctcgcctca atacagaaaa gtttcagcag aactttgcgc     3180

ttgtcttgcc tgactggcag gtgggcgtga aacgtatgct caacgaatta tttacgacta     3240

cggcaattta acaaattttt gcatctcgct catgatgcca gagcgggatg aattaaaagg     3300

aatggtgaaa tgaaaacgcg taaaggtatt attctggctg gtggttccgg cactcgtctt     3360

tatcctgtga cgatggcagt gagtaaacaa ttgctgccga tttatgataa gccgatgatt     3420

tattatccgc tttcaacgct tatgttagcg ggtattcgcg atattcttat tattagtacg     3480

ccacaggata caccgcgttt ccaacaatta ttgggggacg ggagccagtg gggtcttaat     3540

ctacagtata aagtacaacc gagtccggat ggcctggcgc aagcgtttat tattggcgaa     3600

gactttattg gtggtgatga ttgtgcactc gtacttggcg ataatatctt ctatggacac     3660

gacttgccga aattgatgga agctgctgtt aacaaagaaa gcggtgcaac ggtatttgct     3720

tatcacgtta atgatcctga acgctatggt gtcgtggagt ttgataataa cggtacggca     3780

attagcctgg aagaaaaacc gctggagcca aaaagcaact atgcggttac tgggctttat     3840

ttctatgaca atgacgttgt ggaaatggct aaaaacctta agccttctgc ccgtggcgaa     3900

ctggaaatta ccgatattaa ccgtatttat atggaacaag gacgtttgtc tgtagccatg     3960

atggggcgtg gctatgcatg gttggataca gggacgcatc aaagccttat tgaagcaagt     4020

aacttcattg caacaattga agagcgtcag ggattaaagg tatcttgccc ggaagagatt     4080

gcttaccgta aagggtttat tgatgccgag caggtgaaag tattagccga accgcttatc     4140

aagaatcaat atggtcaata tttgctgaaa atgatcagcg aatagtatat gggaactcaa     4200

tgatggatat taaattaatc tctttgcaaa aacatgggga tgagcgcggt gcattaattg     4260

ctcttgaaga gcaacgaaat atacctttcg aagtcaaaag aatatattac atacttgaga     4320

ctcttaatgg agtaagacgc ggatttcatg cgcacaaggt tactcgtcag ttagctattg     4380

tagtcaaggg agcttgtaaa tttcatctgg ataatggtaa agaaacaaag caggtggaac     4440

ttaatgatcc aacaattgcg ttgctgatag aaccctatat atggcatgaa atgtatgatt     4500

ttagtgatga ttgtgtgctg cttgtaattg cggatgattt ctataaagag tctgattata     4560

tccgcaatta tgatgatttt attagaagag taaattcaat tgagaattca taagctaagt     4620

gacgtccaga caacatcaat tggtgatgga acaactatct ggcagtttgt tgtgatacta     4680

aaaggtgctg taattggtaa taattgcaac atctgtgcaa ataccttaat tgaaaataac     4740

gttgtaattg gtaacaatgt cacagtcaaa agcggtgtgt atatttggga tggcgttaaa     4800

atagaggata atgtttttat tggtccttgt gtagcattta caaatgataa gtatcctcgc     4860

tctaaagtct atcctgatga atttttgcaa acaataatac gcaaaggagc atcaataggt     4920

gctaacgcaa ccatcctgcc aggaattgaa attggtgaaa aagcaatcgt tggtgcgggg     4980

agtgttgtaa ccaaaaatgt accgccatgc gcaatagtag taggtaatcc agctcgattt     5040

attaaatggg tagaggataa tgaataaaat tgatttttta gatctttttg caattaacca     5100

gcgacagcac aaagaattag tctctgcgtt tagtagggtg ctagattctg gttggtatat     5160

catgggcgaa gaacttgagc agttcgagaa agagttcgca gaatactgtg gagttaagta     5220

ttgcattggt gtagcaaatg gccttgatgc gttgatacta gtattgaggg catggaaaga     5280

acttggctat cttgaagacg gtgacgaggt attagtaccg gcaaatacat atattgcttc     5340

tattcttgct ataacagaga acaaacttgt tcctgttctt gttgaaccag atatagaaac     5400

ttataatatt aatcctgctt taattgaaaa ttacattacg gaaaaaacta aagcaatatt     5460

accggttcac ttatatggtc tattgtgcaa tatgccagaa attagtgcaa tcgccagaaa     5520

atataatctg ttgattcttg aagattgtgc acaagcacat ggtgcaatac gtgatggtcg     5580

caaagctgga gcttgggggg atgctgcagg atttagtttt tatccaggaa aaaaccttgg     5640

agctttgggg gatgcgggag ctgttactac aaataatgca gaattatcct caactataaa     5700

agctttgcga aattatgggt cacataagaa atatgaaaat atttatcagg gattgaatag     5760

tcgattggat gaactgcaag cagccttatt gcgtgtaaaa atccatacat taccggaaga     5820

tactgcgatt cggcaaagga ttgctgaaaa atatattcgt gaaataaaaa accctgcgat     5880

tacgttacca gtgtacgaag gccaaggtgc gcatgtttgg catttatttg tagtaagaat     5940

cgctaatcgt gaaaaattcc agtcatactt attagagaag ggtatcaaaa ccttaattca     6000

ctatccatta ccaccccata agcagcaagc atatcaaaat atgtctagcc ttagccttcc     6060

aattactgag caaattcatg atgaagtcat ttctttacct ataagtccgg taatgagtga     6120

agatgatgtc aattatgtaa tcaaaatggt caatgattac aagtaatgaa aaaatttctt     6180

caggtaacta tattatccgc tatctataca ttcattaaaa tgattgcggg ttttatcatc     6240

ggtaaggtag tagcaattta tacagggcca tcaggggtag caatgcttgg ccaagtgcaa     6300

agtttaatca caatagttgc aggtactacc tctgcacctg taagcacagg ccttgttcga     6360

tatactgcgg aaaattggca agaaggacaa gaagcatgcg cgccatggtg gcgcgcatgc     6420

ttaagggtta ctctgttttt attcttgctt attattcccg ttgttattat attgtcgaaa     6480

aatattagtg agttactttt tagcgatgga caatacacat ggttaatcat tttcgcatgt     6540

tgtatattgc cattctccat tataaataca ttgatcgctt cagttttaaa tggtcaacaa     6600

ttttataagc aatatatatt ggttgggatg ttttctgtat tcatttctac tatgtttatg     6660

attttgttga ttgtagctta taatcttaaa ggtgcattga ttgccacagc tataaatagt     6720

gctattgctg gtcttgtatt ggttttattt tgtctcaata aatcttggtt tagatttaaa     6780

tattggtggg gtaaaacgga taaagacaaa attataaaaa ttattcatta tactctgatg     6840

gctctggttt ctgttatctc catgcctaca gcattgatgt gtattagaaa aatattgatt     6900

gctaaaactg gttgggagga tgcagggcaa tggcaggccg tatggaagat atctgaggtt     6960

tatcttggtg ttgtgacaat tgctttgtca acatatttct taccaagatt gacaattata     7020

aaaacaagtt tccttataaa aaaagaagta aatagtacta tattatacat aatatctatt     7080

acttcattca tggcgttgag tatctattta ttccgcgatt tggtaataac agttttattt     7140

actgaacagt ttcgctcagc tcgtgaatta tttttattac aacttatagg ggatgtaata     7200

aaaattgctg ggtttcttta tgcataccct cttcaaagtc aggggcatac taaactattc     7260

atcagttcag aagtgatttt ttctatgctc tttatcatta ccacctatat ttttgttgta     7320

aattatggag tacatggtgc taacataagt tatgtcatta catatagttt atattttgtg     7380

tttgcatttg tgtttactaa ttttattaat gttagaagaa ataattaaaa acagaggttg     7440

aattttgaaa ataattatac ctgtcttagg atttggcagg gctggtggtg aaagagttct     7500

ttctaagctg gcaactgaat tgatgaatta tggacatgat gtaagttttg ttgttccaga     7560

taatagaact aatccatatt atgctaccac agcaaaaatt gtcacgagta aatctagtca     7620

aaaccgtgta aaaatattga gaatcattaa aaattactat aatctgtggc gtaaatgcat     7680

agagttaaat cctgatgctg tagttgctag ttttcatttg actgcctatc ttgtcgcatt     7740

attaccaatc acccgtcgta agaaatatta ttatattcag gcgtatgaag ttaatttttt     7800

tgataatata atatggaaat taatagcggg tttaacatat tatttaccgc ttaaaaaaat     7860

actaaatagt cctaatttgc ttcctcataa acatgatgat tttataggag tagttcctgc     7920

aggagtagat ttaaacgttt tctatccgaa accatcaaat aggttattaa atggtcacac     7980

atcaataggg attattggta gaaaagagaa gcacaaagga actagcgaaa ttatttcagt     8040

attgtgttca ctggaaaata aagctggaat tataatcaat attgcgatct atcttgaaga     8100

agttgataag cagcgtttaa tcgctgccgg gtttcaggtt aatttttttc cgattacttc     8160

tgatttagaa ttggcatcct tttatcgaag caatgacatc atgattgctg ttgggttaat     8220

tgaagatggc gctttccatt atccttgtgc tgaatcaatg gcttgtggtt gtcttgttat     8280

ttcaaattat gcgccactta ctgaaactaa cagtgtactt aaattagtca agtttgatgc     8340

ttgcaaactt ggtgaagcaa ttaatctttg tctcaatctt gacctagaag aaaaaagcaa     8400

agaaatccaa tctaatattt ctgtgttgaa taaatatgac tggaaaattg ttggtgaaac     8460

tttcaatagt ttattgttag atgcaaataa atagtatacg ttgatgggga aaatatgaat     8520

attgttaaaa ctgatattcc agatctgatc gttcttgaac caaaagtgtt tagtgatgaa     8580

cgcggctttt ttatggagag ttataatcag attgaatttg agaaggcaat aggaaggcac     8640

gtaaattttg ttcaggataa tcattcaaaa tctagtaaag gcgtactacg tgggttgcat     8700

tatcaattag caccgtatgc acaggctaaa ttagttcgat gtgttgtagg tcaggtattt     8760

gatgttgctg ttgatcttag aaaaaattca ccaacgttca aaaaatggtt tggaataacc     8820

ctttccgcag aaaataaacg acaattatgg atacccgaag gatttgctca tggtttcttg     8880

gtgaccagtg atgaagctga gttcatttat aagacaacta actactatgc tcctggtcat     8940

cagcaagcaa ttatttacaa tgatcctatt ttaaacatcg attggccttt ctgcagtagt     9000

gctctgtcat tatcacaaaa agatcaagaa gcaaaattat tttcagaatt attggacagt     9060

gaactgttct aataaagtgt gccaccttat ccgtctgaag gataggtggt tgcttatatt     9120

tttttgagta tgtttgtata atgacagaaa atagtccgaa atataaacac gataaaagct     9180

taataagttt tatctactta ttttttatat ttacacttat tgtaggcttt attatcgcaa     9240

atacccagtt tttggggcga agtagagact atgataatta tatacagatc ttttctggta     9300

aagaagggga gggggttctt gaattatttt atcgcggatt gatgttaata acgaccagct     9360

atgaaactat catttttata attttaacat gttctttttt tataaaggca aggtttctcg     9420

ctaactattc gcgtaatttt tcaggcttga ccttattctt tatttattat gcaagcgttg     9480

cactttgggt tttagattat actcaattca gaaatggtct atgtatttcc attttaatgt     9540

tttccgtata ctatttattt ataaataaac cgacttattt ttatttctcg gtattatgtg     9600

caattgcaac tcattggtct gctttgcctt ttttgctttt atatcctttt gtctattcaa     9660

caaaaataag acgccttggt tatttttgtt tcagtattct tgttttgatt gcgatctcag     9720

gagaaggaaa agagatcata tcttttataa gaaattttgg agtgggacaa aaaataggaa     9780

atgaagctgg tgtaaattta ataaattcat tatcccttac cgctatttcc tggtttatta     9840

ttagttacat atcaagcatt ggaaatgaaa ggagaaattt aaggcttttc ttttgttatg     9900

gtgtcatgca atacgtgact tttagccttt tctctctacc tgttatggct ttccgtattt     9960

tggaaatgta ttttttcctt atgctaacca ttggggtgtt tattaagcaa aaaaagaatt    10020

attattttat tttttgcaaa gtgttaattt tattgtatct aacatactat tatcatatgg    10080

tctttggagt gattaatgtg taaggctaag gtgttggcta taattgttac ttacaacccg    10140

gaaattattc gattgacgga atgtattaac tctttagccc cacaagttga gagaataatt    10200

cttgtagata atggctcaaa taatagtgat ttgataaaaa atatcagtat taataacctt    10260

gaaattattt tactttcgga aaacaaaggc attgcatttg ctcagaacca tggtgttaag    10320

aagggcctgg aagcaaaaga gtttgactat ttatttttct cagatcagga tacttgcttt    10380

cctagcgatg ttattgaaaa acttaagagt acatttacga aaaataataa aaaaggtaaa    10440

aatgttgctt gtgcttctcc tttttttaaa gaccatcgtt caaattatat gcatccgtca    10500

gtcagcctaa atatttttac gagtacaaaa gttatatgta gtgaagtaga cgatgatctt    10560

tatccctcgc atgttattgc ttctgggatg ttaatgtctc gtgaagcatg gcgcgtcgtc    10620

ggaccatttt gtgaaaaact ctttatagac tgggttgata cagaatggtg ttggcgtgca    10680

ttagctaata atatgattat tgttcagaca ccatcagtca tcatttctca tgaacttggg    10740

tatgggcaga aaatttttgc tggtcgatct gttacaatac ataattcttt cagaaatttt    10800

tataaaatac gcaatgcaat atacttaatg ctgcattcaa attatagctt caagtatcgt    10860

tatcatgctt tttttcatgc gacaaagaat gttgtatttg aaattttata ttcgaaagaa    10920

aaattaaatt cactgaaggt ttgttttaaa gctgtacgtg atggtatgtt caataatttt    10980

taatacgaaa atagttaggc tcaaggtgtt taaatggaag aaaataatat gaagacggtc    11040

gctgtagttg gcacagtggg tgttcctgct tgttatggtg ggttcgaatc acttgttcag    11100

aatctaattg attatcaatc tgatggtata caatatcaga tattttgctc ttcaaaaaaa    11160

tatgataaaa aatttaaaaa ttataaaaat gcagaattaa tctatttgcc gataaatgcc    11220

aatggcgtct ctagcataat ttatgatatt atgtgtttaa ttatttgttt attcaaaagg    11280

ccagatgttg ttttaatatt gggggtgtct ggttgtttat ttctaccaat ttataaacta    11340

ttttcaaaat caaagattat tgtcaatatt gatgggcttg aatggcgtag aaataaatgg    11400

ggaacgtttg ctaagaaatt tcttaaaata tctgaggcga tatctattag aatagctgat    11460

attatcattt cagataatca agcaatagct gattatgtgg aaaataagta caagaaaaaa    11520

agtgtagtta tagcttatgg cggagatcat gccactaatc ttagtacacc gatagacaat    11580

gatcaaaaaa aagaaggtta ttatttgggg ctttgtagga tagagcctga gaataatata    11640

gaaatgattc tgaatgcctt cattaataca gataaaaaaa ttaaatttat gggtaattgg    11700

gataacagcg agtatggacg ccagctaaaa aaatattatt caaactatcc aaatatcacc    11760

ctactagaac ctaactataa tattgaagag ctttataaac taagaaaaaa ttgtcttgca    11820

tacattcatg gacactcggc tggtggaaca aacccttctt tagttgaagc gatgcatttt    11880

aatattccta tttttgcttt cgattgtgac tttaatcgtt acacaactaa caatttagct    11940

cattacttta atgattctga acaacttagc ttattagcag aaagtttgtc ttttggaaat    12000

cttaaatgtc gagtattaga tttaaaaaat tatgctgaag atatgtataa ctggaggcat    12060

atagctgcta tgtatgaatc tatttattaa acgcattaac aataatataa ttgaccttat    12120

atagcaggga aagatcacgt aacgctgcgg cgcgccgatc cccatatgaa tatcctcctt    12180

agttcctatt ccgaagttcc tattctttct agagaatagg aacttcggaa taggaactaa    12240

ggaggatatt catatggata aagccgtaag catataagca tggataagct atttatactt    12300

taataagtac tttgtatact tatttgcgaa cattccaggc cgcgagcatt cagcgcggtg    12360

atcacacctg acaggagtat gtaatgtcca agcaacagat cggcgtagtc ggtatggcag    12420

tgatgggacg caaccttgcg ctcaacatcg aaagccgtgg ttataccgtc tctattttca    12480

accgttcccg tgagaagacg gaagaagtga ttgccgaaaa tccaggcaag aaactggttc    12540

cttactatac ggtgaaagag tttgtcgaat ctctggaaac gcctcgtcgc atcctgttaa    12600

tggtgaaagc aggtgcaggc acggatgctg ctattgattc cctcaaacca tatctcgata    12660

aaggagacat catcattgat ggtggtaaca ccttcttcca ggacactatt cgtcgtaatc    12720

gtgagctttc agcagagggc tttaacttca tcggtaccgg tgtttctggc ggtgaagagg    12780

gggcgctgaa aggtccttct attatgcctg gtggccagaa agaagcctat gaattggtag    12840

caccgatcct gaccaaaatc gccgccgtag ctgaagacgg tgaaccatgc gttacctata    12900

ttggtgccga tggcgcaggt cactatgtga agatggttca caacggtatt gaatacggcg    12960

atatgcagct gattgctgaa gcctattctc tgcttaaagg tggcctgaac ctcaccaacg    13020

aagaactggc gcagaccttt accgagtgga ataacggtga actgagcagt tacctgatcg    13080

acatcaccaa agatatcttc accaaaaaag atgaagacgg taactacctg gttgatgtga    13140

tcctggatga agcggctaac aaaggtaccg gtaaatggac cagccagagc gcgctggatc    13200

tcggcgaacc gctgtcgctg attaccgagt ctgtgtttgc acgttatatc tcttctctga    13260

aagatcagcg tgttgccgca tctaaagttc tctctggtcc gcaagcacag ccagcaggcg    13320

acaaggctga gttcatcgaa aaagttcgtc gtgcgctgta tctgggcaaa atcgtttctt    13380

acgcccaggg cttctctcag ctgcgtgctg cgtctgaaga gtacaactgg gatctgaact    13440

acggcgaaat cgcgaagatt ttccgtgctg gctgcatcat ccgtgcgcag ttcctgcaga    13500

aaatcaccga tgcttatgcc gaaaatccac agatcgctaa cctgttgctg gctccgtact    13560

tcaagcaaat tgccgatgac taccagcagg cgctgcgtga tgtcgttgct tatgcagtac    13620

agaacggtat tccggttccg accttctccg cagcggttgc ctattacgac agctaccgtg    13680

ctgctgttct gcctgcgaac ctgatccagg cacagcgtga ctattttggt gcgcatactt    13740

ataagcgtat cgataaagaa ggtgtgttcc ataccgaatg gctggattaa               13790


<210>  13
<211>  13777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example O6A rfb locus nucleotide sequence - O6A-EPA production 
       strain stGVXN4112 and stLMTB10923

<400>  13
atgacgaatt taaaagcagt tattcctgta gcgggtctcg ggatgcatat gttgcctgcc       60

actaaggcga tacccaaaga gatgctacca atcgtcgaca agccaatgat tcagtacatt      120

gttgacgaga ttgtggctgc agggatcaaa gaaatcctcc tggtaactca cgcgtccaag      180

aacgcggtcg aaaaccactt cgacacctct tatgagttag aatcactcct tgagcagcgc      240

gtgaagcgtc aactgctggc ggaagtacag tccatttgcc cgccgggcgt gacaattatg      300

aacgtgcgtc agggcgaacc tttaggtttg ggccactcca ttttatgtgc acgacctgcc      360

attggtgaca atccatttgt cgtggtgctg ccagacgttg tgatcgacga cgccagcgcc      420

gacccgctgc gctacaacct tgctgccatg attgcgcgct tcaacgaaac gggccgcagc      480

caggtgctgg caaaacgtat gccgggtgac ctctctgaat actctgtcat ccagaccaaa      540

gagccgctgg accgcgaagg taaagtcagc cgcattgttg aattcatcga aaaaccggat      600

cagccgcaga cgctggactc agacatcatg gccgttggtc gctatgtgct ttctgccgat      660

atttggccgg aacttgaacg cactcagcct ggtgcatggg ggcgtattca gctgactgat      720

gccattgccg aactggcgaa aaaacagtcc gttgatgcca tgctgatgac cggcgacagc      780

tacgactgcg gtaaaaaaat gggttatatg caagcgttcg tgaagtatgg actacgcaac      840

ctcaaagaag gggcgaagtt ccgtaaaggg attgagaagc tgttaagcga ataatgaaaa      900

tctgaccgga tgtaacggtt gataagaaaa ttataacggc agtgaagatt agcggcgaaa      960

gtaatttgtt gcgaattttc ctgccgttgt tttatataaa caatcagaat aacaacgact     1020

tagcaatagg attttcgtca aagttttcca ggattttcct tgtttccaga gcggattggt     1080

aagacaatta gcatttgaat tttacgggtt tagcgcgagt gggtaacgct cgtcacatcg     1140

tagacatgca tgcagtgctc tggtagctgt aaagccaggg gcggtagcgt gctgaaatta     1200

taaagtcatt cttatagaac atcgcatttc aataatataa ttacacctaa atgaatagga     1260

tacaacgtgt gcacaattat ttaaggctta aagataaaat aaaaaacgta tttttagggt     1320

tgtatatatt gcagttattt aattatatcg cgccattggt aattatccct atcctgataa     1380

aatatattgg gttgggggaa tatggggaat tggtctatat tacatctatt tatcaaatag     1440

tggctttgat tattgatttt ggctttactt acacaggacc tgtggttgct gcgagacata     1500

gatgtgagac ccaaaattta cagcgctatt actcaatagt tgttctttta aaatcattgc     1560

tttttataat tgcattaaca tgtgtatttt tattgtgcag attaaatata gtccacttgt     1620

cattttttgg gtttttgtca atttttctat gcactattgg taatatatta tcgcccaatt     1680

ggtttttgca ggggattggt gattttaaaa aactttcata ctcacaagta atagtgagaa     1740

taacattgtt tatcatactt cttgtttatg tctgtagtgg cggagataat gtttttatcc     1800

taagtttttt gcaaaatgca acattactca tatgctgtat atacttatgg ccaaatattc     1860

atattagcca tgttgttcat cttaaaccta atgaatgcat tgtggaattt aagaaggcag     1920

gaaatgtttt tattggcgta ataggtacga ttggttacaa tggtctaatt cctgtgttaa     1980

ttggaaacct ttgcggtaat acgagtcttg gtgttttttc aatcgttcaa aaaatgacaa     2040

cagcatgtca aagtctaatt aatccaatat cacagtatat gttatctcaa gtttcagaaa     2100

ttaaacctca agataaactg ttttattata gaattaaaaa aagttttttt gtgcatttaa     2160

caattagcat aattgcatgt ttatgttata tggggttagg gcaatatgtg gcgactttta     2220

taggtaaagt tgacgtttca tttgttatta ttttatttgc gtcaataatt accatttttt     2280

catctttaaa taatgtcctt ggtatacagt ttcttatacc gacagataat gtaaaaatac     2340

tacgaagtat aaatgttatg gcgggaatta ttgttgttag tttgtcctgg ctgttaatat     2400

cacgctttga cattctgggg ggggttttat taaacctaat tggtgagttt cttgtattca     2460

gtatgctagc ttttattgcc catcgaaagt ggggagcgag agtataatga aagtgaaggc     2520

ggttcctgct attacattct atttaagttt aatgctgaca attttagtgt tactgtttgg     2580

taatgaacca aataaatcac aatatatcct tgttatagca acgataacag ttttttatat     2640

cgcatatatc actaataaaa taacttctcc ggccagcctt ctcgttatat catcttttgt     2700

gtttttaggt tgtcgccctt tattatcttt gtttgcaaac tatgattata ggattgccga     2760

ttggtttatt gaaggatata tggatgacga tgtgattttg gctaactatg ctataacact     2820

aatgtattat ggttatacat tgggactaat tctatgcaaa aatactgaaa aattttatcc     2880

gcatggtcct tatcctgaaa aacaattgct aaaaataaag tttcttttga ctttattttt     2940

tctgggttcg ataggtatgg ttgtaaaagg gatattcttt tttaacttta tagaatctaa     3000

tagttatgtt gatatttatc aatcaaatat aacaacgcca ataggttatg attttctatc     3060

ttatttattt tattgttctt ttttccttat atgtgcgttt catatacagt tcagaacaaa     3120

taaaaaattt ctttttattg cgatatgcat tgctgcattt agcaccttga agggtagtcg     3180

tagtgaagct ataacgtttc ttttaacggt tacatgtata tattttaatg aagtaaagac     3240

aagaaactta cgtctgctga ttacaatgat ttttgttttt agcgtcattt ttgtgattag     3300

tgaatttatc tcaatgtggc gcactggagg gagttttttt caattaatgc agggtaataa     3360

tcctgttata aactttgtat acggcatggg agtatcatat ctttccattt atcaatcagt     3420

aaaactacaa ctattgtcag ggggatataa tgttacctat ctattcagcc agttaataat     3480

aacttgctcg tcaatattta atgtcaaatt gagcttgccg gaaataagct atagccattt     3540

ggcctcatac acagcaaacc cagaactata taatcttggg ttcggacttg gggggagtta     3600

tttagcagaa tcgtttttag catttggtct gattggatgt ttcattatac cctttttact     3660

tttacttaat ttaaatgtat tggaaaaata tacaaaaaac aaaccaatta tatattttgt     3720

ttattatagt gtgttgccac ctatattatt cacaccaaga gagactttgt tctatttctt     3780

cccctatctt gtcaaaagta tatttgttgc ttttttagtt acattataca tccagtataa     3840

aaaggattga ccaaaatgtc agaaaaaaat gtcagcataa taatcccaag ttataacagg     3900

gctcatattc ttaaggaggt cataccaagt tattttcagg atgagacttt agaggttata     3960

gttatcaatg atggatcaac agataataca aatagtgtat tagctgaact gaaggaaaaa     4020

tattctcagt tagttatttt agaaaatgaa acgaataaaa aacagatgta ttctaaaaac     4080

cgagggattg aaatagccaa agggaaatat attttttttg gtgatgatga ctcttacctc     4140

ttacccggtg ttatatctcg gttattggct acaaaatatg agacaggcgc tgatgtaatc     4200

ggcgcaagaa tactttatat gaataataac gagaaaacaa ttgaagattg cataaatcga     4260

cataaaaaag aggggcgttt tgttagtgat ctaaatagat tggattttag ttatacatgt     4320

gatttggacc atccgattga atgtttttat gcacagcctt ttgttctagc tgaaagggaa     4380

ctaatatcga aatatcgatt tgatatatct tatacgggaa actgctatcg tgaggaaact     4440

gatttcatgc tatctctatt tattaaaaat aaaaaattta tatatgattc aaaggctttg     4500

ttaataaatt tacctccaag aaaagcgacg ggaggggcaa gaacagctaa tcgattaaaa     4560

tatcattacg aaagttgcat aaataattat agatttttaa aaaaatataa tgataatttg     4620

aatcttcttt caggacaaaa gcatgctata ttttaccgac agtgtcaatt cgttctgcta     4680

aaaatgaagt cgtttatcgg gaagttttta aaatgattat atatatcgcc gcgtataatg     4740

gttcaggagg gcaaggtggg gtggaaaggg ttgttgccca acaatgtaac attcttaaaa     4800

atttgggggt taaagtcatt atacttgata aaacatactt caaaatttct aacaaaattc     4860

gtaacaaaaa aatacaagta gcactttatc caatattagt ttctctttat ttaaccttac     4920

aaaaattacg tggcgtgacg tttaaagtta ttgcacatgg ctattgttct cctttttata     4980

ggaatgacat cttaatagct catggcaata tgaaatgtta ttttcaaaca gtcatgaata     5040

aaaaacctaa tcggttgtct ggcagtggtc ttttatcttt ctatgagcgt tgggctggag     5100

cattttcaaa aaatatctgg gctgtttcaa ataaggttaa aagtgaatgg aatgagcttt     5160

acaatattaa ttcacataaa atcaaagttg ttcgaaattt tataaatctt gcacaatttg     5220

attacactga tgttaatgaa gcagaatatg tgacatttgt cgggcgattg gaaaaaggaa     5280

aaggaataga tgatctgtat tacatatgta aaaatctgcc agatacttcc ttccatttag     5340

tttcaagtat tcccgcccca caaaattttg cttcgctaaa taatgttctg accagcattg     5400

ctgtccccta tgcgaaaatg ccagaaatat ttaagaaatc cagagtactt attttaccgt     5460

cctattatga aggatatgag ctggttacta ttgaagcgct atgctgtggt tgccctgtga     5520

taggctataa tgttggtgca attagagagt tgtatgcaga aagttttcct ggcgtattta     5580

ttgccaataa taaagaagat ttagcacaag tagcctacaa attaattagt cttgataatg     5640

aaaaatatta tcatttgaga caaactattt atagcaagcg tgagcttttt tctgaagaga     5700

gatatgcgga aattttaacg gcggcattta atgaaaaaaa ataagaaact ctgtctcatt     5760

tcaattaact catataatga acttaccgga ggaggagtat atttacgtac gcttgttagt     5820

tttctacaaa aacagaatgt taatttaaca cttattgata aaaaatcctc aggtaaacta     5880

ttcgaagaca atacttttca acatatatca tttattaaag gtaaacgtca ggatataata     5940

tccaggcttt tttttatacc atcattttat gtcccttata ttttctcaat aattaaaatt     6000

ttacggaagc aagatattct tgcttttcac aactctcggc ttggattgtt atgtctgctt     6060

tttagaatac tcatgcccca caaaaagatc atattgttta cggataactt cgaatatgac     6120

ttaataagac aaaaagataa aaacataact acttttattg aaaaattaat tgtttatctc     6180

aatgaattta tcgggcttaa gaattcagat ttagttagct atattacccg gcaagataaa     6240

aatgcaatgg ataaatttta tgggattaaa aaaagcagaa atttaattct ccctgtgata     6300

tttagtagag aaaaaccaac tgatgtattg tcagctcact ttattaatga gtataatcga     6360

ttgaataatg ataataggaa aaaagtagta tttactgcat cttttgattt ttttccaaat     6420

atagatgctg ccaactatgt tttaaatgca gcaaagtcta ataatgatta ttgctatatt     6480

ttggcaggta ggaaaagtac tactttgaat cttcctgatt tggataattt attttttttc     6540

gataatctat ctaatagtga aatgtcatat ttattatctg cttgtgatgt tttttattct     6600

cctatagttt taggaagtgg aatgaaaaca aaaattgcag aagcactatc atatggatta     6660

tatatttatg cgacagagca ttccttaatc ggctatgatg aaattataca caataaggag     6720

tgtgttaaaa aaatctcaca tttggatgag gaatttccta aagatttcaa gatgaaaagt     6780

atcaataaac agctaataat gtcttatcag caaaaatatt attcacatta tcggtttaat     6840

ggccatgaac ttgatataat aaattttgac gattagttag tggagatata atatgaacat     6900

attagtaact ggtggtgctg gatatatcgg atctcatacg gctattgaat tactgaatgc     6960

aggtcatgag attatcgttc tggacaattt cagtaatgct tcatacaagt gtatcgaaaa     7020

aataaaagaa attactcgac gtgattttat aacaattact ggagatgctg ggtgtaggaa     7080

gacactctcc gctattttcg agaaacacgc catagatata gttattcatt ttgctggctt     7140

taaatctgtt tcagagtcta aaagtgaacc cttaaagtat taccagaata atgttggagt     7200

gaccattact ttattacagg taatggaaga gtacagaatt aaaaaattta tctttagttc     7260

atctgcgaca gtctatggtg aaccagagat aattccaatt ccagaaacag ctaaaattgg     7320

aggaactacg aatccatatg gcacatcgaa gtattttgtt gaaaaaattc tagaggatgt     7380

tagttccacg ggaaaactgg atataatttg cttgagatat tttaatcctg tcggtgctca     7440

ttctagtggt aaaataggtg aggctccatc tggtatccct aataatcttg ttccttattt     7500

attggatgtt gcgagtggta aacgtgataa attatttatt tatggcaatg attaccctac     7560

taatgatgga acaggtgtaa gggattttat tcatgttgtt gacttagcga aaggtcattt     7620

ggctgcaatg aattatttaa gtatcaattc gggatataat atctttaatc ttggtacagg     7680

aaaaggttat tcggtacttg aattaatcac tacatttgaa aaattaacaa acattaaggt     7740

caataaatct tttatagaga gaagggcagg ggatgttgcg tcttgttggg ctgatgcaga     7800

taaagctaat tctttattgg actggcaagc cgaacaaact ctagaacaga tgttattgga     7860

ctcgtggcgt tggaaaaaaa attatccaga cggattctga atataaaagg tttcagtttt     7920

atgaatcaat cagagcagag aaaaaaaata ctggttctta cacctcgctt tccctaccct     7980

gtcattggag gggatagatt aagagtctat atgttatgta aagaactttc caaaaaatat     8040

gatcttattc ttctgagctt atgtgatcaa ccactagaac ttgaaataaa tataaatgac     8100

tcggtcttca aagaaattca tcgtgtctat ctaccaaaat ataaatcata ttataatgta     8160

ttaaaagctt tggttacgca aaaaccgttg caaattgctt attatcaatc ggacacattt     8220

aagaataaat acaataaatt aattaaacaa tgcgatgcag tattttgtca tctgataaga     8280

gttgctgatt atgttaagga tacagacaag ttcaaaattc ttgatatgac agatgcaata     8340

tctttgaatt acagtcgcgt taaaaaatta gcaagtaaaa aaagtttgcg tgcaattatt     8400

tattctctgg aacaaaaaag attagaatca tatgaacgtt ctgtggcgaa tctttttgat     8460

ttgaccactt ttatttcatc cgtagaccgt gactatctct accctaatct gggcagtaat     8520

atccatatag tcaataatgg ggttgataca tcagccttga gatatataaa aagagaaata     8580

aaaatcgata agcctgtgga acttatattt atcggaaata tgtattcttt acaaaatatg     8640

gatgctgcaa aacattttgc taagaatatt ttaccttgct tgtatgatga gtttaatatt     8700

atttttaaag tgattggtaa gatctcagaa actaataaaa atatattaaa ttcatttaaa     8760

aatacaattg ctttaggtac tgttgatgat atcaattctt ccgcttctac agggcatata     8820

ggtatatgtc ctgttcgtct tggagcaggc gtacaaaata aaattcttga atacatggct     8880

ttaggtttac catgtattac atctagcatt ggttatgaag gtattaatgc aaaatcaggt     8940

agcgaaattt ttgttgcaga tacagtagag caatataaaa acgtactaag agaaataatt     9000

tacgattata atcgttatac tgaagtggct gaaaatgccc gtagttttgt agaaaataat     9060

ttttcttggg aatcaaaagt tgccaattta atgaatacat tagatgagaa attatatgaa     9120

caataataaa attattacac ctatcattat ggctggtggt tcaggcagtc ggttgtggcc     9180

actatcaaga attctctatc cgaaacaatt tcttagccta atcggtagtc ataccatgct     9240

tcaaacaacg gctaatcgtc tggatggttt ggattgtacc aacccttatg tcatttgtaa     9300

tgaacaatac cgctttatag ttgctgaaca gcttagaaaa atcgatagat tgacttcaaa     9360

gaatatcatc cttgagcctg ttgggcgtaa cactgcccct gcaattgcat tagcggcgtt     9420

gctgatgtct aagtctgata aaagtgcaga tgatcttatg ctcgtactgg ctgcagatca     9480

cgttatacac gatgaagaaa aattttgtaa cgctgttaga tcggcaattc catacgctgc     9540

tgatgggaaa ttggtaacat ttggtataat tccagacaaa gcagaaactg gttatggtta     9600

tatacatcga ggacaatata ttaatcagga agattcggat gcatttatag tgtcatcatt     9660

tgttgaaaag ccaaatcatg agacagccac taaatatctt gcttccggtg agtattattg     9720

gaatagcggt atgtttttgt ttagtgcaaa tcgttatata gaggaactta aacaatttcg     9780

gcctgatatt ttatccgctt gtgaaaaagc aattgcttca gcgaactttg accttgattt     9840

tgtgcgttta gatgaaagtt ctttctctaa gtgccctgaa gaatcaattg attacgctgt     9900

aatggaaaaa acaaaagacg caattgttat tccaatggat gctggctgga gtgatgtcgg     9960

ttcatggtct tctctttggg aaattaatga taaagactca gacggcaacg taatagttgg    10020

ggatattttc tctcatgaaa caaagaattc tttcatatat gccgaatcgg gaattgttgc    10080

tacagttgga gtggaaaatt tagttgttgt ccaaacaaag gatgctgttc ttgtctcaga    10140

gagaaataaa gttcaggatg taaagaaaat agtagaacaa attaaaaatt caggtcgtag    10200

cgagcattat gttcatcgcg aagtatatcg tccttggggt aaatatgatt ccattgacac    10260

aggggagcgt tatcaggtca aacgtataac agtaaatcct ggtgaaggac tttctttaca    10320

aatgcaccat catagggcag aacattggat catagtttct ggaactgcaa gggtgactat    10380

aggttctgaa actaagattc ttagcgaaaa tgaatctgtt tacatacctc ttggtgtaat    10440

acactgcttg gaaaatccag ggaaaattcc tcttgattta attgaagttc gttctggatc    10500

ttatttagaa gaagacgatg ttatccgttt tcaggaccga tatggtcgta gctaaatttt    10560

tgataatgta acgttagtag aagagcgcta atatttttag ttaatctgta ataagtatta    10620

tttgtttaag gtatatcatg tcgagtttac cctgctttaa agcctatgat attcgcggga    10680

aattaggcga agaactgaat gaagatattg cctggcgcat tggtcgcgct tatggcgaat    10740

ttctcaaacc gaaaaccatt gtgttaggcg gtgacgtccg actcaccagc gaaaccttaa    10800

aactggcgct ggcgaagggg ttacaggatg cgggcgtcga tgtgctggat attggcatgt    10860

ccggcaccga agagatctat ttcgccacgt tccatctcgg cgtggatggc ggcatcgaag    10920

ttaccgccag ccataacccg atggattaca acggcatgaa actggtgcgc gaaggggctc    10980

gcccgatcag cggtgatacc ggactgcgcg acatccagcg tctggcagaa gccaacgact    11040

ttcctcccgt tgatgaaacc aaacgcggtc gctatcagca aatcaatctg cgtgacgctt    11100

acgttgatca cctgttcggt tatatcaacg tcaaaaacct cacgccgctc aagctggtga    11160

ttaactccgg gaacggcgcg gcgggtccgg tggtggacgc cattgaagcc cgctttaaag    11220

ccctcggcgc acccgtggaa ttaatcaaag tgcacaacac gccggacggc aatttcccca    11280

acggtattcc taacccgcta ctgccggaat gtcgcgacga cacccgcaat gcggtcatca    11340

aacacggcgc ggatatgggc attgcctttg atggcgattt tgaccgctgt ttcctgtttg    11400

acgaaaaagg gcagtttatt gagggctact acattgtcgg cctgctggca gaagcgttcc    11460

tcgaaaaaaa tcccggcgcg aagatcatcc acgatccacg tctctcctgg aacaccgttg    11520

atgtggtgac tgccgcaggc ggcaccccgg taatgtcgaa aaccggacac gcctttatta    11580

aagaacgtat gcgcaaggaa gacgctatct acggtggcga aatgagcgcc caccattact    11640

tccgtgattt cgcttactgc gacagcggca tgatcccgtg gctgctggtc gccgaactgg    11700

tgtgcctgaa aggaaaaacg ctgggcgaac tggtgcgcga ccggatggca gcgtttccgg    11760

caagcggtga gatcaacagc aaactggcac accccgttga ggcgattaac cgcgtggaac    11820

agcactttag ccgcgaggcg ctggcggtgg atcgcaccga tggcatcagc atgacctttg    11880

ccgactggcg ctttaacctg cgctcctcta acaccgaacc ggtggtgcgg ttgaatgtgg    11940

aatcgcgcgg cgatgtaccg ctgatggaag aaaagacaaa acttatcctt gagttactga    12000

acaagtaatt cagtaatttc atataaatgg gttttaaaaa acggaaaaga tgagatatcc    12060

ggtgtggtat atccaaggta atgctattca gtatctctat gagtgagtta acatctatac    12120

cacatttaag ccgcacactt cgggatcccc atatgaatat cctccttagt tcctattccg    12180

aagttcctat tctttctaga gaataggaac ttcggaatag gaactaagga ggatattcat    12240

atggataaag ccgtaagcat ataagcatgg ataagctatt tatactttaa taagtacttt    12300

gtatacttat ttgcgaacat tccaggccgc gagcattcag cgcggtgatc acacctgaca    12360

ggagtatgta atgtccaagc aacagatcgg cgtagtcggt atggcagtga tgggacgcaa    12420

ccttgcgctc aacatcgaaa gccgtggtta taccgtctct attttcaacc gttcccgtga    12480

gaagacggaa gaagtgattg ccgaaaatcc aggcaagaaa ctggttcctt actatacggt    12540

gaaagagttt gtcgaatctc tggaaacgcc tcgtcgcatc ctgttaatgg tgaaagcagg    12600

tgcaggcacg gatgctgcta ttgattccct caaaccatat ctcgataaag gagacatcat    12660

cattgatggt ggtaacacct tcttccagga cactattcgt cgtaatcgtg agctttcagc    12720

agagggcttt aacttcatcg gtaccggtgt ttctggcggt gaagaggggg cgctgaaagg    12780

tccttctatt atgcctggtg gccagaaaga agcctatgaa ttggtagcac cgatcctgac    12840

caaaatcgcc gccgtagctg aagacggtga accatgcgtt acctatattg gtgccgatgg    12900

cgcaggtcac tatgtgaaga tggttcacaa cggtattgaa tacggcgata tgcagctgat    12960

tgctgaagcc tattctctgc ttaaaggtgg cctgaacctc accaacgaag aactggcgca    13020

gacctttacc gagtggaata acggtgaact gagcagttac ctgatcgaca tcaccaaaga    13080

tatcttcacc aaaaaagatg aagacggtaa ctacctggtt gatgtgatcc tggatgaagc    13140

ggctaacaaa ggtaccggta aatggaccag ccagagcgcg ctggatctcg gcgaaccgct    13200

gtcgctgatt accgagtctg tgtttgcacg ttatatctct tctctgaaag atcagcgtgt    13260

tgccgcatct aaagttctct ctggtccgca agcacagcca gcaggcgaca aggctgagtt    13320

catcgaaaaa gttcgtcgtg cgctgtatct gggcaaaatc gtttcttacg cccagggctt    13380

ctctcagctg cgtgctgcgt ctgaagagta caactgggat ctgaactacg gcgaaatcgc    13440

gaagattttc cgtgctggct gcatcatccg tgcgcagttc ctgcagaaaa tcaccgatgc    13500

ttatgccgaa aatccacaga tcgctaacct gttgctggct ccgtacttca agcaaattgc    13560

cgatgactac cagcaggcgc tgcgtgatgt cgttgcttat gcagtacaga acggtattcc    13620

ggttccgacc ttctccgcag cggttgccta ttacgacagc taccgtgctg ctgttctgcc    13680

tgcgaacctg atccaggcac agcgtgacta ttttggtgcg catacttata agcgtatcga    13740

taaagaaggt gtgttccata ccgaatggct ggattaa                             13777


<210>  14
<211>  15027
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example O8 rfb locus nucleotide sequence - O8-EPA production 
       strain stLMTB11734

<400>  14
atgacgaatt taaaagcagt tattcctgta gcgggtctcg ggatgcatat gttgcctgcc       60

actaaggcga tacccaaaga gatgctacca atcgtcgaca agccaatgat tcagtacatt      120

gttgacgaga ttgtggctgc agggatcaaa gaaatcctcc tggtaactca cgcgtccaag      180

aacgcggtcg aaaaccactt cgacacctct tatgagttag aatcactcct tgagcagcgc      240

gtgaagcgtc aactgctggc ggaagtacag tccatctgtc cgccgggcgt gaccattatg      300

aacgtgcgtc agggcgaacc tttaggttta ggccactcca ttttgtgtgc gcgacctgcc      360

attggtgaca acccatttgt cgtggtactg ccagacgttg tgatcgacga tgccagcgcc      420

gacccgctac gttacaacct tgctgccatg attgcacgtt tcaacgaaac gggccgcagc      480

caggtgctgg caaaacgtat gccgggtgac ctctctgaat actccgtcat ccagactaaa      540

gagccgctgg accgtgaggg taaagtcagc cgcattgttg aatttatcga aaaaccggat      600

cagccgcaga cgctggactc agacatcatg gccgtaggtc gctatgtgct ttctgccgat      660

atttggccgg aactggaacg tactcagcct ggtgcatggg gacgtattca gctgactgat      720

gctattgccg agctggcgaa aaaacaatcc gttgatgcaa tgctgatgac cggcgacagt      780

tacgactgcg gcaaaaaaat gggctatatg caggcgtttg tgaagtatgg cctacgcaac      840

ctgaaagaag gggcgaagtt ccgtaaaggt attgagaagc tgttaagcga ataatgaaaa      900

tctgaccgga tgtaacggtt gataagaaaa ttataacggc agtgaaaatt cgcagcaaaa      960

gtaatttgtt gcgaatcttc ctgccgttgt tttatataaa ccatcagaat aacaacgagt     1020

tagcagtagg gttttattca aagttttcca ggattttcct tgtttccaga gcggattggt     1080

aagacaatta gcgtttgaat ttttcgggtt tagcgcgagt gggtaacgct cgtcacatca     1140

taggcatgca tgcagtgctc tggtagctgt aaagccaggg gcggtagcgt gcattaatac     1200

ctctattaat caaactgaga gccgcttatt tcacagcatg ctctgaagta atatggaata     1260

aattaagcta gcgatcgctt aagatctagg atttcattat gttacttcct gtaattatgg     1320

ctggtggtac cggcagtcgt ctctggccga tgtcacgcga gctttatccg aaacagttcc     1380

tccgcctgtt cgggcagaac tccatgctgc aggaaaccat cacccgactc tcgggccttg     1440

aaatccatga accgatggtc atctgtaacg aagagcaccg cttcctggtg gctgaacagc     1500

tacgccagct caataagctg tcgaataata ttattcttga gccggtcggg cgcaacaccg     1560

ccccggccat cgccctggca gcccttcagg ccacccgcga cggcgacgac ccgctgatgc     1620

tggttctcgc cgctgaccat atcatcaata accagtcggc cttccacgac gccatccggg     1680

tcgccgagca gtatgctgat gaaggtcatc tggtcacctt cggtatcgtg ccgaatgccc     1740

cggaaactgg ctacggttac attcagcgcg gcgtggcgct caccgatagt gcccattccg     1800

cgtaccaggt ggcccgcttt gtggagaagc cggatcgcga gcgcgccgag gcttacctcg     1860

cctccgggga gtactactgg aacagcggca tgtttatgtt ccgcgccaag aaatacctca     1920

tcgagctggc caaataccgt ccggatatcc tggaagcctg ccaggctgcg gtgaatgccg     1980

ccgataatgg cagcgatttc atcaatatcc cgcatgatat tttctgcgag tgcccggatg     2040

agtccgtgga ctatgccgtt atggagaaaa ccgccgatgc ggtggtggtc ggtctcgatg     2100

ctgactggag cgacgtcggc tcctggtccg cactatggga ggtcagcccg aaagacgagc     2160

agggcaatgt cctcagcggt gacgcgtggg tacacaacag cgaaaactgc tacatcaaca     2220

gcgacgagaa gctagtggcg gccattggcg tagagaatct ggtgattgtc agcactaagg     2280

acgccgtgct ggtgatgaat cgcgagcgtt cccaggacgt gaagaaggcg gtcgagttcc     2340

tcaagcagaa ccagcgcagc gagtacaagc gccaccgtga gatttaccgc ccctggggcc     2400

gttgcgacgt agtggtccag accccgcgct tcaacgtcaa ccgcatcacg gtgaaaccag     2460

gcggtgcctt ctcgatgcag atgcaccacc atcgcgccga gcattgggtt attctcgccg     2520

gcaccggtca ggtgactgtc aacggtaagc agttcctgtt gtccgagaac cagtccacct     2580

ttattccgat tggcgccgag cactgcctgg aaaaccctgg ctgtattccg ctggaagtgc     2640

tggagatcca gtcgggggcg taccttggcg aggacgacat tattcgtatt aaagaccagt     2700

atggtcgttg ctaattattt tcgggacaag acgcagaatg acacagttaa cttgttttaa     2760

agcttatgac atccgtggtg aactgggtga ggaactgaac gaggacatcg cctaccgtat     2820

cggtcgcgcc tacggcgaat ttctgaaacc cgggaagata gtggtggggg gcgatgtgcg     2880

cctcacaagc gagtcgctga agctggcgct ggcccgcggg ttaatggacg ccggtaccga     2940

cgtgctggac atcggcctga gcggtaccga agagatttac tttgccacct tccaccttgg     3000

ggtagatggt ggcatcgagg tgaccgcgag ccacaatcct atgaactaca acggcatgaa     3060

gctggtgcgc gagaatgcga agcccatcag cggcgacacc ggcctgcggg atatccagcg     3120

cctggcggag gaaaaccagt tcccgccagt ggacccggcg cgtcgcggga ccctgagcaa     3180

gatatcggta ctgaaggagt atgttgacca tctgatgagc tacgtggact tctcgaactt     3240

cacccgtcca ctgaagttgg tggtgaactc cggaaacggg gctgcggggc acgtgattga     3300

tgaggtggag aaacgcttcg cggcggctgg ggtgccggta acctttatca aggtgcatca     3360

ccagccggat ggccatttcc ctaacggtat cccgaatccg ctgctgccgg agtgccgcca     3420

ggataccgcc gacgcggtgc gcgagcatca ggccgacatg gggattgcct ttgacggcga     3480

cttcgatcgc tgcttcctgt tcgatgacga agcttcgttt atcgaggggt attacattgt     3540

cggcctgctg gctgaggcgt tcctgcagaa gcagccggga gcgaaaatca ttcacgaccc     3600

gcgcttgacg tggaacacgg tagacatcgt gacccgcaac ggcggccagc cggtgatgtc     3660

gaagacgggg catgcgttca tcaaggagcg gatgcgtcag gaagacgcta tctacggcgg     3720

ggagatgagt gcgcaccatt acttccgcga tttcgcctac tgcgatagcg ggatgatccc     3780

gtggctgctg gtggcggagc tgctgtgtct gaagaacagc tcgctgaaat cgctggtggc     3840

ggaccgccag aaggcgttcc ctgcgtcggg agagatcaac cgcaagctaa gtaatgctgc     3900

tgaggcgatc gcccgcatcc gggcgcagta tgagccggcg gctgcacaca tcgacacaac     3960

ggacgggatc agtattgaat accctgaatg gcgctttaac ctgcgcacgt ctaacaccga     4020

gccggtggtg cgtctgaacg ttgagtccag agctgatgtg gcgcttatga atgaaaaaac     4080

gaccgagctg ttacacctgt taagcgggga ataaggtgag agatttacta acgacgattt     4140

atcgttatcg gggatttatc tggagcagtg ttaaacgtga ttttcaggca cgctatcaaa     4200

ctagtatgct gggcgcacta tggctcgttt tacaaccgct ctctatgatt ctggtctata     4260

ccctggtttt ttccgaggtg atgaaggcaa gaatgcccga taataccggg tcgtttgcct     4320

atagtattta tctctgttcc ggggtactga cctggggatt atttactgag atgctggata     4380

aaggtcagag cgtatttatt aacaatgcta atctgatcaa gaaactcagt tttccgaaaa     4440

tctgtctgcc gatcatcgtg acgttatcgg cggtgctaaa tttcgcgatt attttcagtc     4500

tgtttctaat ttttatcatt gtcaccggta acttccccgg ctggctcttt ctctcggtga     4560

taccggtcct gcttttgcag atcctgtttg ccggtgggct ggggatgatc cttggtgtca     4620

tgaacgtctt tttcagggat gtggggcaac tggttggcgt tgcgctgcaa ttctggtttt     4680

ggttcacacc cattgtttat gtactgaatt cattacctgc atgggcaaaa aatctgatga     4740

tgtataaccc gatgactcgg atcatgcaat cttatcagtc catcttcgcc tatcatctgg     4800

cccccaactg gtattcgcta tggccagtat tggctctcgc cattattttc tgcgtcatcg     4860

gtttcaggat gttccgcaag catgcggcgg atatggtgga tgaattataa tgagttatat     4920

cagagtaaat aatgtcggta aggcgtatcg ccagtatcac tcaaagaccg ggagactgat     4980

cgaatggtta tcccctctga ataccaaacg ccataatttg aaatggatcc tccgcgatat     5040

taatttcgaa gtcgctccgg gcgaggctgt cggtattatc ggtatcaacg gtgcaggcaa     5100

gagtaccctg cttaaactca taaccgggac gtccaggccg acgactggag aaattgaaat     5160

ctccggacgt gtcgctgcat tactcgaatt ggggatgggg tttcattctg atttcactgg     5220

tcggcagaat gtttatatgt ctgggcaact gttggggtta tcgtcagaga aaataactga     5280

actgatgccg caaattgaag agtttgctga gattggggac tatatcgatc aacctgtgcg     5340

cgtctactcc agtgggatgc aagttcgatt agcttttagt gtagcgacgg ctatccgtcc     5400

tgatgtgcta attatcgatg aggcattatc tgttggggat gcatatttcc agcataaaag     5460

ctttgagcgt attcgaaaat ttcgtcagga agggaccacg ctgttgctgg tatcccatga     5520

taaacaagcg atccaaagca tttgcgaccg ggccatttta ttgaataaag gccaaattga     5580

aatggaaggt gaacctgaag cagtgatgga ttattacaat gctcttctgg ccgataaaca     5640

aaatcagtcc attaaacaag ttgagcataa tggtaaaacg caaactgttt caggcactgg     5700

tgaggtgact atctctgagg ttcatcttct cgatgaacag ggcaatgtga ctgaatttgt     5760

ttcggtaggg catcgtgtca gcttgcaggt caacgttgag gtcaaggacg atattcctga     5820

gcttgttgtc ggatatatga ttaaggatcg acttgggcag ccgattttcg ggaccaatac     5880

gtaccatctc aatcagacac tcacctccct gaaaaaagga gaaaagcgtt cgttcttatt     5940

ttctttcgat gcgagattgg gggttggctc ctattctgtc gctgtcgcgt tgcatacttc     6000

cagtacgcac ctcggcaaaa actatgaatg gcgcgatctg gccgtggtat tcaacgtcgt     6060

taacacggaa caacaagagt ttgtcggcgt gtcctggttg ccgcctgaac tggagatttc     6120

ttaatgggtt cgtcgtttta tcgttcattt gaagaacgac acagaggttc ggttgaagaa     6180

atcaagcgcc gcttgagttt ttatttacct tttcttgcag gtctgaagga catttatcct     6240

gatggcgtga ttgcggatat tggttgcgga cgtggcgaat ggttggagat cctgactgaa     6300

aatggcattg cgaacatcgg cgtcgatctc gatgatggca tgctggcgcg cgccagggag     6360

gccggactga atgtgcagaa aatggattgt ctgcagtttt tgcaaagtca ggcggatcag     6420

agcctgatag cgttgaccgg ttttcatatt gctgagcatt tgccgtttga ggtcctgcag     6480

caactcgcca tgcataccct acgggtgctg aaaccaggtg gtttgctgat cctcgaaacg     6540

ccgaacccgg agaatgtaag cgtcggcacc tgttcatttt atatggatcc aacgcataat     6600

catcctctgc caccgccact gcttgagttt ttacctattc attatggttt tacccgagca     6660

attaccgttc gtctgcagga aaaagaggtt cttcaatctc cggatgcagc cgttaatttg     6720

gtcgatgtac tcaaaggggt gagccccgac tacagcatca ttgctcagaa agcagcgcca     6780

acagatattc ttgaacgctt tgacaccctg tttacccagc agtacggtct gacgctggat     6840

gctctgagca accgttacga tgcgattttg cgccaacagt tttcgtccgt tgtctcacgg     6900

ctggagacgt tgaaccaaac ctatatgcaa cagataagcc aaatgtcaga gactattcag     6960

acgttgcaag gtgaggttga cgatctgagt catgtcatcg atcagaacca tcagcttcat     7020

cagcaaatgg cggatttaca taacagtcgt tcatggcgta ttactcaacc actacgctgg     7080

ttgtctttgc aacgtcaatt attacgtcag gaaggggcta aagtgcgagc ccgtagggct     7140

gggaaaaaaa tattgcgcaa agggatggcg ctctcgctgg tctttttcca tcgttaccct     7200

aagtctaagg tttatctgtt taaggttctg agaaaaactg gctgctatac attgctacaa     7260

cgtttgttcc aacgcgtaat gctggtgcaa tctgacacga tgatgatgca gtccagaaga     7320

tatgatgtgg gtactgaaga aatgacaagt cgcgcgatga gtatttataa cgaattaaaa     7380

aataaaaata cggagaaata acgatgcgta ttgtcataga tttacaaggc gcacagacgg     7440

aaagccgctt tcgtggcatc ggtcgttata gtatcgcaat cgccagaggc ataatcagaa     7500

ataacagccg gcatgagatt ttcatcgcgc tatccgccat gctggatgag tcgattgcaa     7560

atattaaggc gcaatttgcc gatctcctgc cggcagaaaa tatagtcgta tggcatgccg     7620

taggccctgt tcgtgcgatg gaccaaggta atgaatggcg tcgggagagc gcagaactga     7680

ttcgggaagc gtttcttgaa tcattgtgtc cagatgtcgt tttcattacg agtttgtttg     7740

aaggtcatgt cgacgatgcg gctacatcgg tacacaaatt tagtcgtcag tataaagtag     7800

ccgtactgca ccacgatctt atccccctcg tgcaggcgga aacctatctg caggacgatg     7860

tatacaaacc ctactattta cagaaagttg agtggttaaa aaacgctgac cttttgttga     7920

ctaactctgc ttataccgca caggaagcga tcgagcatct gcatttacag ggcgatcatg     7980

tgcagaatat tgcagccgca gtcgattctc agttttgtat ggcggaggtg gcagcgagcg     8040

aaaaagagac cgtccttggc cattacggta ttcagcgcga gttcatgttg tatgcgcccg     8100

gaggatttga ctcaaggaaa aactttaaac ggttgattga ggcctatgcc gggctcagtg     8160

atgccttacg tcgcagtcat caactggtca tcgtcagtaa gctttccatc ggtgatcgtc     8220

agtatctgga atcccttgcg tcaggtaatg gtttacagca gggcgaactg gtactcactg     8280

gttatgtgcc ggaagatgag ctgatccagc tctatcgcct atgtaagctg ttcatctttg     8340

cttcactaca tgaaggtttt gggttgccgg ttctggaagc aatgtcgtgc ggtgcgccgg     8400

tgattggctc aaatgtcacc agtattcctg aagtcatcgg taatcctgag gcattattcg     8460

acccgtattc tgtctcttcc atgagggata agatcgcgca atgtttgact gatgatacct     8520

tcctcgcgcg tctgaaagaa atggcgcagc agcaagcgcg taatttctct tgggataaag     8580

ctgcggtgac tgctctggaa gctttcgaaa agatcgcggt agaagacacc ggtactgcgc     8640

aggttttgcc tgaagctttg attcagaaga tccttgctat ctcacaaggg cagccagatg     8700

accgcgatct gcgcttgtgc gcaacggcca ttgattacaa tctgaaaacg gcagaacttt     8760

atcaaatcga cgataaatcg ctgaactggc gtgtggaagg cccattcgat agctcatata     8820

gtctggcgtt ggtcaaccgc gaatttgccc gggcactctc agccgatggt gtagaggttt     8880

tattgcattc cactgaagga ccaggtgatt ttgccccaga tgcctcgttt atggcacagt     8940

cggaaaatag tgatcttctg gcattttata atcaatgtca gacccgcaag agtaacgaaa     9000

agatagatat tattagcaga aatatctatc caccgcgggt taccaaaatg gatgccaaag     9060

taaaattcct tcattgttat gcttgggaag aaacgggctt tccgcaaccg tggatcaatg     9120

aatttaatcg ggaacttgac ggagtgctgt gtacttcgga acatgttcgt aaaatactga     9180

ttgataacgg actgaatgtg cccgcatttg ttgttggcaa tggctgtgac cattggctca     9240

atatcccagc cgagacgaca aaagatgtgg atcacggaac attccgtttc ctgcacgtct     9300

cttcttgttt cccacgcaaa gggatacagg caatgcttca ggcttggggg aaggcgttca     9360

ctcgtcgtga caatgttatc ttaatcatta agacttttaa caatccgcac aatgaaattg     9420

acgcatggct ggctcaggcc caggctcaat tcatagacta tcccaaagtt gaagtgatca     9480

aagaggatat gtcagccacc gagcttaaag ggctttatga aagctgtgat gttttggttg     9540

ctccaggttg cgctgaaggc tttggtttac ctattgctga agcaatgctg agtgggctac     9600

cggctatcgt caccaattgg agcgggcaac ttgattttgt taattcacaa aattcatggc     9660

tggttgacta tcagttcact cgggtaaaaa cgcactttgg tctgttttcc tcagcctggg     9720

ccagtgtgga tattgacaac ttaacagatg cattaaaagc ggcagcctca accgataaat     9780

cagtgctgcg tgacatggcc aatgctggtc gcgagcttct tctgcagcag tttacctgga     9840

aagcggtggc tgatcgttct tgccaggcgg tcaagactct gcgtgcgcat attgatattg     9900

cacagcatcg ggcgcgcatt ggctgggtga cgacctggaa cacgaaatgt gggatcgcaa     9960

cctattccca gcatctggtg gaaagcgcac ctcatggcgc ggatgttgtt tttgctcccc    10020

aggtcagcgc tggcgatctt gtgtgtgcag acgaagagtt tgtacttcgc aactggattg    10080

taggtaaaga gagcaactat ctggaaaacc tccagccaca cattgatgct ctgagactcg    10140

atgtcattgt gatccaattc aactatggat tctttaatca tcgagaactg tcggcgttta    10200

ttcgtcgcca gcatgacgcc ggtcgttcag ttgttatgac gatgcactca actgtggatc    10260

cgctggaaaa agagccgagc tggaatttcc gtcttgctga aatgaaagag gcgctggcac    10320

tttgcgaccg gttgttggtg cattcgattg ccgatatgaa ccgccttaaa gatttaggct    10380

taactgcgaa tgttgcttta ttcccgcacg gtgttatcaa ctactccgca gcgagcgtca    10440

cacgtcaaca gcagtcttta ccgctaattg cgagctatgg cttctgctta ccgcataagg    10500

gcctgatgga actagtagaa tccgtccata gactcaagca agccggtaaa ccggttcgtt    10560

tacgactggt gaacgcagag tatcctgttg gggagtcacg cgatctggtg gcagagctta    10620

aagctgctgc tcagcggtta ggtgttaccg atctgattga gatgcataat gatttcctac    10680

ctgatgcgga gagtctgcgg ttgctttcag aagccgatct tctgattttt gcttatcaga    10740

atactgggga gtctgctagc ggggcggtac gttatggtat ggcgactcaa aaacctgttg    10800

cggtaacgcc cctggcgata tttgatgatt tggacgatgc cgtctttaaa tttgatggat    10860

gcagcgtcga tgatatcagt caggggattg accggatcct gaattccatc cgtgaacaga    10920

actcttgggc aaccaggact caacaacgtg ccgatgcatg gcgggaacaa catgattatc    10980

aagctgtttc acgccgtctg gttaatatgt gtcaaggctt agctaaagct aaatatttta    11040

aataaaaata tctctcttgt attttttgcc tttgaataca agaggggtta gataatgtgt    11100

catttattat gaaaattatt tttgctactg agccaattaa atacccatta acgggcatcg    11160

gtcggtattc cctggagctg gttaagcggc tggcggtcgc ccgcgaaatt gaagaattaa    11220

agctatttca cggtgcgtcg tttatagaac agatcccttt ggtggagaat aaaagcgata    11280

ccaaagccag caatcatggt cgtctgtcgg cgtttctacg ccgacagacg ctgttgattg    11340

aggcttatcg cttgctgcat ccgcggcgcc aggcgtgggc attgcgcgac tataaggatt    11400

atatctacca tggccccaat ttttatctgc cgcataaact ggaacgcgcc gtgaccacgt    11460

ttcatgacat atccattttt acctgcccgg aatatcatcc aaaagatcgg gttcgctata    11520

tggagaagtc cctgcatgag agtctggatt cggcaaagct gatcctgacc gtttctgatt    11580

tctcgcgcag tgaaattatc cgcttgttca actatccggc ggagcggatc gtaaccacca    11640

agctagcctg cagcagtgac tatatcccac gcagcccggc agagtgtctg ccggtactgc    11700

agaaatatca gctggcgtgg caggcctacg cgctatatat cggcactatg gagccacgta    11760

aaaatatccg aggcctgctg catgcctatc agctgctacc gatggagatc cgcatgcgct    11820

atccgctaat ccttagcggc tatcgcggct gggaagacga tgtgctgtgg cagttagtcg    11880

agcgcggtac tcgggaaggc tggatccgtt acctcggata tgttccggat gaagacctgc    11940

cgtatctgta cgcagcggcc agagtctttg tttatccctc cttctacgag ggattcggtt    12000

tacctattct tgaagcgatg tcttgcggtg tgccggtagt atgctccaat gtcacctctt    12060

tgcctgaggt tgttggcgat gccggcctcg ttgccgatcc taatgatata gacgcgatta    12120

gcgcgcaaat tttgcagagc ctgcaagatg atagctggcg ggaaatcgcc accgcgcgcg    12180

gtcttgctca ggcgaaacag ttttcgtggg agaactgtgc gacacagacc attaacgcct    12240

ataaattact ctaagggtgt cagttgagag ttctacacgt ctataagact tactatcccg    12300

atacctacgg cggtattgag caggtcattt atcagctaag tcagggctgc gcccgccggg    12360

gaatcgcagc cgatgttttc acttttagcc cggacaaaga tacaggtcct gtcgcttacg    12420

aagatcatcg ggtcatttat aataaacagc tttttgaaat tgcctccacg ccgttttcgc    12480

tgaaagcgtt aaagcgtttt aagctgatta aagatgacta cgatatcatc aactaccatt    12540

ttccgtttcc ctttatggat atgctgcatc tttcggcgcg gcctgacgcc aggactgtgg    12600

tgacctatca ctctgatata gtgaaacaaa aacggttaat gaagctgtac cagccgctgc    12660

aggagcgatt tctcagcggc gtagattgca tcgttgcctc gtcgcccaat tacgtggctt    12720

ccagccagac cctgaaaaaa tatctggata aaacggtggt gatcccgttt ggtctggagc    12780

agcaggacgt gcagcacgat ccgcagaggg tcgcgcactg gcgggaaact gtcggcgata    12840

agttctttct cttcgtcggc actttccgct actacaaagg gctgcatatt ctgatggatg    12900

ccgctgagcg tagccgactg ccagtggtgg ttgtaggggg cgggccgctg gaatcggaag    12960

tgcggcgtga agcgcagcag cgcgggctga gcaatgtgat gtttaccggc atgctcaacg    13020

acgaagataa gtacattctc ttccagctct gccggggcgt ggtattcccc tcgcatctgc    13080

gctctgaggc gtttggcatt acgttattgg aaggcgcacg ctttgcaagg ccgctgatct    13140

cttgcgagat cggtacaggt acctctttca ttaaccagga caaagtgagt ggttgcgtga    13200

ttccgccgaa tgatagccag gcgctggtgg aggcgatgaa tgagctctgg aataacgagg    13260

aaacctccaa ccgctatggc gaaaactcgc gtcgtcgttt tgaagagatg tttactgccg    13320

accatatgat tgacgcctat gtcaatctct acactacatt gctggaaagc aaatcctgag    13380

cggccgcgag ctcgtcgact cgaggatccg tgtaggctgg agctgcttcg aagttcctat    13440

actttctaga gaataggaac ttcggaatag gaactaagga ggatattcat atggataaag    13500

ccgtaagcat ataagcatgg ataagctatt tatactttaa taagtacttt gtatacttat    13560

ttgcgaacat tccaggccgc gagcattcag cgcggtgatc acacctgaca ggagtatgta    13620

atgtccaagc aacagatcgg cgtagtcggt atggcagtga tgggacgcaa ccttgcgctc    13680

aacatcgaaa gccgtggtta taccgtctct attttcaacc gttcccgtga gaagacggaa    13740

gaagtgattg ccgaaaatcc aggcaagaaa ctggttcctt actatacggt gaaagagttt    13800

gtcgaatctc tggaaacgcc tcgtcgcatc ctgttaatgg tgaaagcagg tgcaggcacg    13860

gatgctgcta ttgattccct caaaccatat ctcgataaag gagacatcat cattgatggt    13920

ggtaacacct tcttccagga cactattcgt cgtaatcgtg agctttcagc agagggcttt    13980

aacttcatcg gtaccggtgt ttctggcggt gaagaggggg cgctgaaagg tccttctatt    14040

atgcctggtg gccagaaaga agcctatgaa ttggtagcac cgatcctgac caaaatcgcc    14100

gccgtagctg aagacggtga accatgcgtt acctatattg gtgccgatgg cgcaggtcac    14160

tatgtgaaga tggttcacaa cggtattgaa tacggcgata tgcagctgat tgctgaagcc    14220

tattctctgc ttaaaggtgg cctgaacctc accaacgaag aactggcgca gacctttacc    14280

gagtggaata acggtgaact gagcagttac ctgatcgaca tcaccaaaga tatcttcacc    14340

aaaaaagatg aagacggtaa ctacctggtt gatgtgatcc tggatgaagc ggctaacaaa    14400

ggtaccggta aatggaccag ccagagcgcg ctggatctcg gcgaaccgct gtcgctgatt    14460

accgagtctg tgtttgcacg ttatatctct tctctgaaag atcagcgtgt tgccgcatct    14520

aaagttctct ctggtccgca agcacagcca gcaggcgaca aggctgagtt catcgaaaaa    14580

gttcgtcgtg cgctgtatct gggcaaaatc gtttcttacg cccagggctt ctctcagctg    14640

cgtgctgcgt ctgaagagta caactgggat ctgaactacg gcgaaatcgc gaagattttc    14700

cgtgctggct gcatcatccg tgcgcagttc ctgcagaaaa tcaccgatgc ttatgccgaa    14760

aatccacaga tcgctaacct gttgctggct ccgtacttca agcaaattgc cgatgactac    14820

cagcaggcgc tgcgtgatgt cgttgcttat gcagtacaga acggtattcc ggttccgacc    14880

ttctccgcag cggttgccta ttacgacagc taccgtgctg ctgttctgcc tgcgaacctg    14940

atccaggcac agcgtgacta ttttggtgcg catacttata agcgtattga taaagaaggt    15000

gtgttccata ccgaatggct ggattaa                                        15027


<210>  15
<211>  11283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example O15 rfb locus nucleotide sequence - O15-EPA production 
       strain stLMTB11738

<400>  15
atgacgaatt taaaagcagt tattcctgta gcgggtctcg ggatgcatat gttgcctgcc       60

actaaggcga tacccaaaga gatgctacca atcgtcgaca agccaatgat tcagtacatt      120

gttgacgaga ttgtggctgc agggatcaaa gaaatcctcc tggtaactca cgcgtccaag      180

aacgcggtcg aaaaccactt cgacacctct tatgagttag aatcactcct tgagcagcgc      240

gtgaagcgtc aactgctggc ggaagtacag tccatctgtc cgccgggcgt gaccattatg      300

aacgtgcgtc agggcgaacc tttaggttta ggccactcca ttttgtgtgc gcgacctgcc      360

attggtgaca acccatttgt cgtggtactg ccagacgttg tgatcgacga tgccagcgcc      420

gacccgctac gttacaacct tgctgccatg attgcacgtt tcaacgaaac gggccgcagc      480

caggtgctgg caaaacgtat gccgggtgac ctctctgaat actccgtcat ccagactaaa      540

gagccgctgg accgtgaggg taaagtcagc cgcattgttg aatttatcga aaaaccggat      600

cagccgcaga cgctggactc agacatcatg gccgtaggtc gctatgtgct ttctgccgat      660

atttggccgg aactggaacg tactcagcct ggtgcatggg gacgtattca gctgactgat      720

gctattgccg agctggcgaa aaaacaatcc gttgatgcaa tgctgatgac cggcgacagt      780

tacgactgcg gcaaaaaaat gggctatatg caggcgtttg tgaagtatgg cctacgcaac      840

ctgaaagaag gggcgaagtt ccgtaaaggt attgagaagc tgttaagcga ataatgaaaa      900

tctgaccgga tgtaacggtt gataagaaaa ttataacggc agtgaaaatt cgcagcaaaa      960

gtaatttgtt gcgaatcttc ctgccgttgt tttatataaa ccatcagaat aacaacgagt     1020

tagcagtagg gttttattca aagttttcca ggattttcct tgtttccaga gcggattggt     1080

aagacaatta gcgtttgaat ttttcgggtt tagcgcgagt gggtaacgct cgtcacatca     1140

taggcatgca tgcagtgctc tggtagctgt aaagccaggg gcggtagcgt gcattaatac     1200

ctctattaat caaactgaga gccgcttatt tcacagcatg ctctgaagta atatggaata     1260

aattaagcta gcatgagcaa aactaaacta aatgttcttt accttgcaat aagtcagggt     1320

gccaattacc tactgccatt attaattttt ccttatcttg ttagagtcat tggtgtatcg     1380

aattttggtg atctgagttt ttcattgata actatacaag tgttgttaat ggttgttgaa     1440

tatggttttg gatatagtgg gacaagagaa atagcactaa ataacgataa aaaataccat     1500

tctgaatttt tttgcggtgt ggtgcttgct cgttttatat taatgctaat tgcagctata     1560

atactcataa tactctgttt tttttatgtt tttaacgacg ttaagtcttt gttatgtgtt     1620

ggttttctgt ccgtaattgc aggtgttttc aatccaaatt ggtttttgca aggtaaggaa     1680

atgatgagtg tgatggctgt gctgtcacta ttttcacgag gcatagcagt cgttgcagtt     1740

tatctaatta taaaacccgc aacgccgatg tacatcagtg ccttattatt gagcatgcca     1800

tatattttgt attcattctg tggcgttgcc tacttactta ttatcaagga gattttttta     1860

tgtaggccac cgataaagaa aattcaagta attttaaaaa atggatttca ttttttttgt     1920

tcaacacttg cgactagtgc atacacaatg ttgacccctc ttgtattggg tggcgtatct     1980

ggaaagtttg atgtaggcat ctttaactca gctaacatga tcaaacaagg tttggctgga     2040

cttgcatcac cattagtcca agctttttat ccaagaatta acattttgca aagagagaat     2100

ccatatattg caaacttaaa atctagaatg attcttaaat acttgcttgt tttttacatg     2160

gctttagcaa taccattttt actttttgcc aaccaattat cattattaat attcggcatg     2220

aaaggtgaag taattgcagg tgcaatgcaa ttaatgacat tgcttcctat attcataggt     2280

tttaatacag ttgtcgggtt acttgtatta gtacctaatg ggatgcaaaa acagtatttc     2340

aaatctattt tcctaggaac tattacttgt ttaagcatag tttatccagc atgtaaatat     2400

tatggagcaa cgggtgcgat tgtgagtctt attgtagctg aaattttcgt tggcatggga     2460

atgcttaaac aattcattaa agtaaataaa accgtatgta ggcctcataa attatgaata     2520

tctcggtaat aatatctgtt tggaaacgcc cagttcaatt agaattgatt ctctctgagc     2580

tcgattctca ggctaaagac aatagtctac acctagaagt aattgtttcc gatagtcata     2640

gtggtaaaga aattgatgat gtagttgctg ataatattca taaaaagaaa aatattaata     2700

ttatccatca acatactaaa aatatactct ccgctaagcg caatttcgga gcatccctag     2760

cccatgggga ttatttaata tttcttgatg atgattgtat acccgcaagt ggatatatat     2820

catcgttgct gaactattta aaaaaaatga atagtaaaag cgttttatgt ggggaagtta     2880

gattcgaaaa tgaactcatt gagaccagca attactatcg ctacaggaac tctttacacc     2940

ctaagtttag tgatagtcct gatatctcta tgaatgcctg gacttttgtc gcaatgaatt     3000

gtgttcttga tagaaaggca ttttcatcag gtatagtttc atataatgaa aattttattg     3060

gttatggttg tgaagatcat gagtttgggt ggcaacttga aaaaaatgac ttcaaaatta     3120

tttttgctga ttttaaaata ttacatcacg aatacagtgg cgatatagaa ggatatacaa     3180

aaaaaattcg tgctacagca cgtgatggta tgaatgtatt aagcaaagta aggcctgaaa     3240

tgttttctac taataaaaaa ttattcctag ttgagaaaat atttagtaaa cacaaaacgt     3300

ttagtaaaat atgccaatca atatttttca ataaatttat ttttaaaaaa ataatacaat     3360

ttttaaaaaa aacagatgca aataaaaaac tctatttccc aattctttac agatatgtgt     3420

tgatttcggc atatatacat ggtattggag agcgtggcac ctcaaaaaca gatgatttgc     3480

ttaagaactg gtatatatag atgatgctat cttcatttat taagacattt gtatggaagg     3540

taaaaaacaa tgaagtataa tgcattgatg gcttttttat tattttttgt tgtttttttt     3600

agattgtcgc tgataatacc tttcttatat ttggcattta ttcctgcatt ttttggtatt     3660

atgtatttag tgcgtaattt tatgattact atgggcaatg gattggtatc tatagatcgt     3720

aaaaatttgt tgctgttatc tatattcata attatttttt tattttgttt ggttttcgat     3780

ttgtttcaaa aaagccattc ttttcaaagt tattttaccg ttagattatt tatgttgttt     3840

ttattttcat ttgttcctgc gtattattta gtaaatagat tcataaaggg tgacttgaaa     3900

ttaatggagc gaatattagt gtattctctc tgggttcaaa tagttatttt ttttggtatg     3960

tatataagtc cagagttaaa aagattgtta tatactttct ttggtatgtc tgactctgtt     4020

aatctttggg aacaaaatgc taaagtaaga ggatttgggt tgtcgggtga aataaatttc     4080

atgacaccat ttttgatgat ctatatgtca ttttttatga tgaaaaggcg ttatgcttta     4140

attactttaa tttgtctgac tcaaatcgta aattctaaca tggctgtgat tgcagccatt     4200

attggtatcg gttgctctag acttaatatt aatataaaaa ttgcaacagt attgattttg     4260

ggagttttag tttatagctt aggagcggtg ttctttcctc gattttatga tgagttcgtt     4320

tctggagatg gcacaagaac tctggatatc ttattacagc aacatgtgtt tgttgtaggt     4380

aatttagatt tttttaatat tatatttgga ttacagcaaa acatatcttc atcaatcccc     4440

gatattaaac aaagttcgga tatgggctgg gttatactgt ttaattacgg tgggttaaca     4500

tttattacac tctttttatt tttaatcttt actatttcta ttgcgacatt tggaatgaca     4560

tatcaagcaa ttatatggat gttaattggg ataattttca ataccaaagg tttagtttta     4620

ggatctaacg gctatttctt tctatctttt atatatatgt ttttgaatag agtaacactt     4680

agtggacaga gttcaattac taataagtta ggtcaagtaa gtaaatagct tccagagtat     4740

atttgtcaat gatttgaggt tcggttatta tgttttcatc taaaacactg ttaattactg     4800

gtggtactgg ctctttcggg aatgctgtat taaatagatt tcttgataca gatattgcag     4860

aaatccgtat atttagtcgt gatgaaaaaa aacaagatga tatgcggaaa aaatacaata     4920

atcaaaaatt aaagttctat attggtgatg tcagagatta ccgtagtatt ttgaatgcga     4980

ctcgcggtgt tgattttata tatcatgcag cggcacttaa gcaagttcca tcatgtgaat     5040

ttcatcctat ggaagccgtt aaaactaata tccttggtac ggaaaatgtt cttgaagcag     5100

ctatagcgaa tgaagtgaag agggttgtat gcctaagtac tgataaagct gtatacccga     5160

ttaacgcaat gggtatttca aaagctatga tggaaaaggt catggtcgcg aaatcccgta     5220

atgttgatcg caataaaaca gtaatatgtg gtacccgtta tgggaatgtt atggcatctc     5280

gcggttcagt tattccatta tttgttgatc ttattagagc gggcaagcca ctcacaataa     5340

ctgatcctaa tatgacccgc tttatgatga ctcttgagga tgcggtagat ttagttcttt     5400

atgcgtttga acatggtaat aatggtgata tctttgtgca aaaagcacct gcagcaacta     5460

ttgacacatt agctattgct ttaaaggaat tactaaatgt tcctgaccat ccggtaaatg     5520

tcattggaac gcgtcatggc gagaaattat atgaagctct acttagtcgt gaggaaatga     5580

tcgctgctat agatatgggc gattattacc gtgtcccgcc agatcttcgt gaccttaatt     5640

atggcaaata tgttgagcaa ggtgatagcc gaatatctga aatagaagat tataactctc     5700

ataatactca acggttagat gttgaaggca tgaaagagct cttgctaaaa ttagccttta     5760

ttcgagcaat tcgtgctggt gaaaaatata atctggattc atgatatgaa aatattagtt     5820

actggtgcaa atggttttat tggtcgtaat ttatgtttga ggcttgagga acttggttat     5880

aaagatctta ttagaattga tcgagaatca acgaagcaag atcttgaaca aggcttacag     5940

gatgccgatt ttatttatca cttagctggt atcaatagac ctaagactga tgatgagttt     6000

atttctggaa acagtgattt aacaaagcat atagttgagt atctcctttc tattggtaag     6060

aatacaccaa ttatgctaag ttcttcgata caagctgaac ttaataatgc ttatggggtt     6120

agcaaagctg tagctgaaag ctatgtcgaa aaatatgctg ctgctagtgg ttcttcgtat     6180

tatattttca gatatccaaa cgtttttggt aaatggtgta agccaaacta taattctttt     6240

atagcaactt tttgctacaa tatttccaat gatattgaga ttactatcaa tgatgcagca     6300

gcgccagtca atctggtcta tattgatgat gtttgtactg atgctatagc tcttctctct     6360

gggacggttg aaagtggata taaagttgtt gcaccaattt attcaacaac agttggtgaa     6420

gttgcagaat taatttatag cttcaaaaat agccgttcca ccctgatcac agaggctgtc     6480

ggggcgggat ttacccgtgc attgtattct acatggctga gttatttacc agcagagaag     6540

tttgcgtaca aggtaccttt ttatggggat gcccgcggag tcttttgtga gatgttgaaa     6600

acgccttcag cggggcagtt ttcatttttt actgctcacc ctggtattac gcgtggcgga     6660

cattaccatc acagtaaaaa tgagaagttt ttggtcattc gaggtcaggc atgctttaaa     6720

tttgaacatg tgattaccgg tgagcgatat gaactgaaag tttcatcggg tgagtttaag     6780

attgttgaaa cagttcctgg ttggacacat gacattacaa atattggaac tgatgaatta     6840

atagtcatgc tctgggcaaa tgaaattttc aaccgtgatg agcccgatac tattgcgaga     6900

cctctataat gaaaaaatta aaagttatgt ctgttgttgg aacccgtcct gagattatcc     6960

gtttgtcgag ggttcttgct aagtttgatg aatactgcga gcatattatt gtccatactg     7020

gtcaaaatta tgattacgaa ttaaatgaag tgttcttcaa tgacttgggt gttcgaaaac     7080

ctgattattt tttaaatgca gcgggtaaaa atgcggcgga aaccattggt caggttatta     7140

ttaaggtaga tgaagtatta gaaatcgaaa aacctgaagc aatactggta ttgggcgata     7200

cgaattcatg tatttctgcc attccggcca aacgccgtaa agtgcctata tttcatatgg     7260

aagcaggtaa ccgttgtttc gatcaacgcg tgcctgaaga aaccaacaga cgtattgttg     7320

accatacggc tgatatcaat atgacctaca gtgatattgc tcgtgaatat ctcttggctg     7380

aaggtatccc agctgatcgg atcataaaaa ctggtagccc tatgtttgag gttctttcat     7440

attatatgcc ccaaattgat ggttcagatg tgctatcgcg tttgaatcta cagtctggtg     7500

agttttttgt agtaagtgcg catcgtgaag agaatgttga ttctccaaaa cagctcgtaa     7560

agcttgcgaa cattctaaat actgttgctg aaaaatataa tcttccagtt attgtctcca     7620

cacacccaag gacacgtaac cgaatccgtg agcaaggaat tgaatttcat tcaaatataa     7680

atctactgaa accattgggt ttccatgatt ataaccactt gcagaagaac tcacgagctg     7740

tgctttcaga tagcggtact atcactgaag agtcatccat catgaatttc ccagcggtaa     7800

acatccggga agcgcatgag cgtccggaag gctttgagga agcatccgtc atgatggtgg     7860

ggttagagtg tgaacgcgta ttacaagcgc tggatattct ggcaacacaa ccgcgaggtg     7920

aagtccgtct tttacgtcag gttagtgatt acagcatgcc aaatgtgtcg gataaagttg     7980

tcagaattgt tcactcttac acagattatg ttaagagagt cgtctggaaa gaatattgat     8040

gaaacttgct ttaatcatag atgattacct gcccaacagt actcgtgttg gtgcaaaaat     8100

gtttcatgaa cttgctcaag aatttatcca gcgtgggcac gatgttacgg taattactcc     8160

tggtacgggc atgcaagaag agatttcttt tgataccttt cagggggtaa aaacatggcg     8220

ttttaaaagc gggccgctca aggatgtaag taaaattcag cgagcggtca atgaaacgct     8280

tttgtcctat cgggcgtgga aagccatcaa aaaatgggta aaaaaagaga cctttgaggg     8340

ggtgatttat tattcacctt ccatattctg ggggccttta gttaaaaaaa ttaaagctcg     8400

ttgccaatgt cctgcttatc ttattttaag agatatgttt ccacaatggg taattgatgc     8460

aggaatgctt aatgctggtt ccccaataga acgctacttt cgtctttttg aaaaaatatc     8520

ttatcgtcag gcaaatcgta ttggacttat gtctgataag aatcttgatg tttttcggaa     8580

agataataaa ggctatccgt gcgaagtttt gcgtaattgg gcatccctaa caccaacgat     8640

catacccaag gattatatac cactacgtaa gcgacttggc ctagaggata aaaccatttt     8700

cttctatggt ggaaacatag gtcatgcaca ggacatgaca aacttgatgc gacttgtgag     8760

aaacatggca gcatatcctc aagctcattt cctatttatt ggccaggggg atgaagttga     8820

attaattaat tcattagcat ctgagtgggc attgacgaat ttcacctatt tgccctcggt     8880

taaccaagat gaatttaagt tcattttgtc ggaaatggat atcggcttgt tttctctttc     8940

cgctagacac tcttcccata attttcctgg taagttatta ggctatatgg ttcagtcgct     9000

acctatttta ggtagcgtaa atgccggaaa tgatttgctc gacattgtca atcaaaataa     9060

tgcgggatta atccatgtca atggtgagga cgataaatta tgtcaatctg cgctattaat     9120

gttgcatgat attgatgtgc gccggcaact tggttcgggg gcgaatatat tgttgaaaga     9180

acaattctcc gttgagtctg cggcacagac gatagaaatg aggttggagg catgcaatgc     9240

gattaattga taatgaccaa ctcgacgaat tatatgatca agccgggcaa tcggaacgtt     9300

tacgttccca ccttatgatg cacggctcgc atcaagaaaa ggtacagcgt ttacttattg     9360

cattagtaaa gggcagctat gttgaaccgc attatcacga acttcctcat cagtgggaaa     9420

tgttcattgt tatggagggg caacttcagg tttgtttgta tggtagaaat ggtgaggtta     9480

taaagcaatt tatagcagga gataatactg gaatgagcat tgtggagttt tctccgggcg     9540

atatacacag tgtcgaatgc ctatctccgc gtgctcttat ggtggaagtt aaggaggggc     9600

catttgaccc ttcttttgca aaatcgttcg tgtgagcggc cgcgagctcg tcgactcgag     9660

gatccgtgta ggctggagct gcttcgaagt tcctatactt tctagagaat aggaacttcg     9720

gaataggaac taaggaggat attcatatgg ataaagccgt aagcatataa gcatggataa     9780

gctatttata ctttaataag tactttgtat acttatttgc gaacattcca ggccgcgagc     9840

attcagcgcg gtgatcacac ctgacaggag tatgtaatgt ccaagcaaca gatcggcgta     9900

gtcggtatgg cagtgatggg acgcaacctt gcgctcaaca tcgaaagccg tggttatacc     9960

gtctctattt tcaaccgttc ccgtgagaag acggaagaag tgattgccga aaatccaggc    10020

aagaaactgg ttccttacta tacggtgaaa gagtttgtcg aatctctgga aacgcctcgt    10080

cgcatcctgt taatggtgaa agcaggtgca ggcacggatg ctgctattga ttccctcaaa    10140

ccatatctcg ataaaggaga catcatcatt gatggtggta acaccttctt ccaggacact    10200

attcgtcgta atcgtgagct ttcagcagag ggctttaact tcatcggtac cggtgtttct    10260

ggcggtgaag agggggcgct gaaaggtcct tctattatgc ctggtggcca gaaagaagcc    10320

tatgaattgg tagcaccgat cctgaccaaa atcgccgccg tagctgaaga cggtgaacca    10380

tgcgttacct atattggtgc cgatggcgca ggtcactatg tgaagatggt tcacaacggt    10440

attgaatacg gcgatatgca gctgattgct gaagcctatt ctctgcttaa aggtggcctg    10500

aacctcacca acgaagaact ggcgcagacc tttaccgagt ggaataacgg tgaactgagc    10560

agttacctga tcgacatcac caaagatatc ttcaccaaaa aagatgaaga cggtaactac    10620

ctggttgatg tgatcctgga tgaagcggct aacaaaggta ccggtaaatg gaccagccag    10680

agcgcgctgg atctcggcga accgctgtcg ctgattaccg agtctgtgtt tgcacgttat    10740

atctcttctc tgaaagatca gcgtgttgcc gcatctaaag ttctctctgg tccgcaagca    10800

cagccagcag gcgacaaggc tgagttcatc gaaaaagttc gtcgtgcgct gtatctgggc    10860

aaaatcgttt cttacgccca gggcttctct cagctgcgtg ctgcgtctga agagtacaac    10920

tgggatctga actacggcga aatcgcgaag attttccgtg ctggctgcat catccgtgcg    10980

cagttcctgc agaaaatcac cgatgcttat gccgaaaatc cacagatcgc taacctgttg    11040

ctggctccgt acttcaagca aattgccgat gactaccagc aggcgctgcg tgatgtcgtt    11100

gcttatgcag tacagaacgg tattccggtt ccgaccttct ccgcagcggt tgcctattac    11160

gacagctacc gtgctgctgt tctgcctgcg aacctgatcc aggcacagcg tgactatttt    11220

ggtgcgcata cttataagcg tattgataaa gaaggtgtgt tccataccga atggctggat    11280

taa                                                                  11283


<210>  16
<211>  13435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example O16 rfb locus nucleotide sequence - O16-EPA production 
       strain stLMTB11739

<400>  16
atgacgaatt taaaagcagt tattcctgta gcgggtctcg ggatgcatat gttgcctgcc       60

actaaggcga tacccaaaga gatgctacca atcgtcgaca agccaatgat tcagtacatt      120

gttgacgaga ttgtggctgc agggatcaaa gaaatcctcc tggtaactca cgcgtccaag      180

aacgcggtcg aaaaccactt cgacacctct tatgagttag aatcactcct tgagcagcgc      240

gtgaagcgtc aactgctggc ggaagtacag tccatctgtc cgccgggcgt gaccattatg      300

aacgtgcgtc agggcgaacc tttaggttta ggccactcca ttttgtgtgc gcgacctgcc      360

attggtgaca acccatttgt cgtggtactg ccagacgttg tgatcgacga tgccagcgcc      420

gacccgctac gttacaacct tgctgccatg attgcacgtt tcaacgaaac gggccgcagc      480

caggtgctgg caaaacgtat gccgggtgac ctctctgaat actccgtcat ccagactaaa      540

gagccgctgg accgtgaggg taaagtcagc cgcattgttg aatttatcga aaaaccggat      600

cagccgcaga cgctggactc agacatcatg gccgtaggtc gctatgtgct ttctgccgat      660

atttggccgg aactggaacg tactcagcct ggtgcatggg gacgtattca gctgactgat      720

gctattgccg agctggcgaa aaaacaatcc gttgatgcaa tgctgatgac cggcgacagt      780

tacgactgcg gcaaaaaaat gggctatatg caggcgtttg tgaagtatgg cctacgcaac      840

ctgaaagaag gggcgaagtt ccgtaaaggt attgagaagc tgttaagcga ataatgaaaa      900

tctgaccgga tgtaacggtt gataagaaaa ttataacggc agtgaaaatt cgcagcaaaa      960

gtaatttgtt gcgaatcttc ctgccgttgt tttatataaa ccatcagaat aacaacgagt     1020

tagcagtagg gttttattca aagttttcca ggattttcct tgtttccaga gcggattggt     1080

aagacaatta gcgtttgaat ttttcgggtt tagcgcgagt gggtaacgct cgtcacatca     1140

taggcatgca tgcagtgctc tggtagctgt aaagccaggg gcggtagcgt gcattaatac     1200

ctctattaat caaactgaga gccgcttatt tcacagcatg ctctgaagta atatggaata     1260

aattaagtga aaatacttgt tactggtggc gcaggattta ttggttcagc tgtagttcgt     1320

cacattataa ataatacgca ggatagtgtt gttaatgtcg ataaattaac gtacgccgga     1380

aaccgggaat cacttgctga tgtttctgat tctgaacgct atgtttttga acatgcggat     1440

atttgcgatg cacctgcaat ggcacggatt tttgctcagc atcagccgga tgcagtgatg     1500

cacctggctg ctgaaagcca tgttgaccgt tcaattacag gccctgcggc atttattgaa     1560

accaatattg ttggtactta tgtccttttg gaagccgctc gcaattactg gtctgctctt     1620

gatagcgaca agaaaaatag cttccgtttt catcatattt ctactgacga agtctatggt     1680

gatttgcctc atccagatga agtaaataat acagaagaat tacccttatt tactgagacg     1740

acagcttacg cgccaagcag cccttattcc gcatccaaag catccagcga tcatttagtc     1800

cgcgcgtgga aacgtacata tggtttaccg acaattgtga ctaattgctc gaacaactat     1860

ggtccttatc atttcccgga aaagcttatt ccactggtta ttcttaatgc actggaaggt     1920

aaggcattac ctatttatgg caaaggagat cagatccgcg actggttgta tgttgaagat     1980

catgcgcgtg cgttatatac cgtcgtaacc gaaggtaaag cgggtgaaac ttataacatt     2040

ggtgggcaca acgaaaagaa aaacatcgat gtagtgctca ctatttgtga tttgctggat     2100

gagattgtac cgaaagagaa atcttatcgt gagcaaatca cttatgttgc tgatcgtccg     2160

ggacacgatc gccgctatgc tattgatgct gagaagattg gtcgcgcatt gggatggaaa     2220

ccacaggaaa cgtttgagag cgggattcgt aaaacggtgg aatggtacct gtccaataca     2280

aaatgggttg ataatgtgaa aagtggtgcc tatcaatcgt ggattgaaca gaactatgag     2340

ggccgccagt aatgaatatc ctcctttttg gcaaaacagg gcaggtaggt tgggaactac     2400

agcgtgctct ggcacctttg ggtaatttga ttgcttttga tgttcactct actgattatt     2460

gcggtgattt tagtaatcct gaaggtgtag ctgaaaccgt aagaagcatt cggccggata     2520

ttattgtcaa tgcagccgct cacaccgcag tagacaaagc agaatcagaa ccggagtttg     2580

cacaattaat taacgcaaca agtgtcgaag cgattgcgaa agcagcaaat gaagttggag     2640

cctgggttat ccattactcg actgattacg tcttccctgg aaatggcgat atgccatggc     2700

tggagacgga tgcaaccgca ccactaaatg tttacggtga aaccaagtta gccggagaaa     2760

aagcgttaca ggaatattgc gcgaagcatc ttattttccg gaccagctgg gtctatgcag     2820

gaaaaggaaa taacttcgcc aaaacgatgt tacgtctggc aaaagagcgt gaagaattag     2880

cggttattaa cgatcagttt ggtgcgccaa caggtgctga actgctggct gattgtacag     2940

cacatgccat tcgtgtcgca ctgaataaac cggatgtcgc aggcttgtac catttggtag     3000

ccagtggtac cacaacctgg tacgattatg ctgcgctggt ttttgaagag gcgcgcaaag     3060

caggcattcc ccttgcactc aacaagctca acgcagtacc aacaacagcc tatcctacac     3120

cagctcgtcg tccacataac tctcgcctta atacagaaaa atttcagcag aactttgcgc     3180

ttgtcttgcc tgactggcag gttggcgtga aacgaatgct caatgaatta tttacgacta     3240

cagcaattta atagtttttg catcttgttc gtgatggtgg agcaagatga attaaaagga     3300

atgatgaaat gaaaatgcgt aaaggtatta ttttagcggg tggttctggt acacgtcttt     3360

atcctgtgac tatggctgtc agtaaacagc tattacctat ttatgataaa ccgatgatct     3420

attacccgct ctctacactg atgttggcgg gtattcgcga tattttgatt atcagtacac     3480

ctcaggatac tcctcgtttt caacaattgc tgggtgacgg tagccagtgg ggcctgaatc     3540

ttcagtacaa agtgcaacct agcccagatg gcctcgcgca ggcatttatc atcggtgaag     3600

agtttattgg tggtgatgat tgtgctttgg ttcttggtga taatatcttt tacggtcacg     3660

atctgccgaa gctaatggag gccgctgtta acaaagaaag tggtgcaacg gtatttgcct     3720

atcacgttaa tgatccagaa cgctatggtg tcgttgagtt tgataaaaac ggtacggcaa     3780

tcagtctgga agaaaaaccg ttagaaccaa agagtaatta cgccgttaca ggtctgtact     3840

tttatgataa cgacgtggtt cagatggcga aaaacttgaa gccgtctgca cgtggtgagt     3900

tagaaattac agatattaac cgtatttatc ttgagcaggg acgtctgtct gtcgcgatga     3960

tggggcgtgg ctacgcgtgg ctggacacgg ggactcatca gagtctgata gaagcaagta     4020

attttattgc gacaattgaa gagcgccagg gattgaaggt ttcctgtcct gaagagattg     4080

catttcgtaa aggttttatt gatgttgagc aagtaagaaa attagctgta ccactaataa     4140

agaataatta tgggcagtat ctttataaaa tgacgaagga ttcaaattaa tgaatgtgat     4200

tagaactgaa attgaagatg tgctaattct ggagccaaga gtatttggtg atgatagagg     4260

tttcttttat gagagcttta atcaatcagc atttgaacat attctaggct atccggtcag     4320

ctttgttcaa gacaatcact cacgttcatc aaaaaatgta ctcagaggcc ttcactttca     4380

acgcggcgag tacgcacaag ataaacttgt acgctgcact catggagcag tttttgatgt     4440

tgctgttgat attcgaccca attcggtatc ctttggtaaa tgggttggtg ttctgctttc     4500

agctgataat aagcagcagt tgtggatacc aaaagggttt gctcatggct ttttggttct     4560

gtctgatatc gctgaatttc aatataaaac tacaaactat tatcatcctg aaagcgattg     4620

tggaatatgt tggaatgatg aacgcattgc aattgattgg ccccaaacat cagggttaat     4680

cctttcgcca aaagatgaaa ggctctttac gttagatgag cttatcagat taaaattaat     4740

tgcatgaata cgaataaatt atctttaaga agaaacgtta tatatctggc tgtcgttcaa     4800

ggtagcaatt atcttttacc attgcttaca tttccatatc ttgtaagaac acttggtcct     4860

gaaaatttcg gtatattcgg tttttgccaa gcgactatgc tatatatgat aatgtttgtt     4920

gaatatggtt tcaatctcac agcaactcag agtattgcca aagcagcaga tagtaaagat     4980

aaagtaacgt ctattttttg ggcggtgata ttttcaaaaa tagttcttat cgtcattaca     5040

ttgattttct taacgtcgat gaccttgctt gttcctgaat ataacaagca tgccgtaatt     5100

atatggtcgt ttgttcctgc attagtcggg aatttaatct accctatctg gctgtttcag     5160

ggaaaagaaa aaatgaaatg gctgacttta agtagtattt tatcccgctt ggctattatc     5220

cctctaacat ttatttttgt gaacacaaag tcagatatag caattgccgg ttttattcag     5280

tcaagtgcaa atctggttgc tggaattatt gcactagcta tcgttgttca tgaaggttgg     5340

attggtaaag ttacgctatc attacataat gtgcgtcgat ctttagcaga cggttttcat     5400

gtttttattt ccacatctgc tattagttta tattctacgg gaatagttat tatcctggga     5460

tttatatctg gaccaacgtc cgtagggaat tttaatgcgg ccaatactat aagaaacgcg     5520

cttcaagggc tattaaatcc tatcacccaa gcaatatacc caagaatatc aagtacgctt     5580

gttcttaatc gtgtgaaggg tgtgatttta attaaaaaat cattgacctg cttgagtttg     5640

attggtggtg ctttttcatt aattctgctc ttgggtgcat ctatactagt aaaaataagt     5700

atagggccgg gatatgataa tgcagtgatt gtgctaatga ttatatcgcc tctgcctttt     5760

cttatttcat taagtaatgt ctatggcatt caagttatgc tgacccataa ttataagaaa     5820

gaattcagta agattttaat cgctgcgggt ttgttgagtt tgttgttgat ttttccgcta     5880

acaactcttt ttaaagagat tggtgcagca ataacattgc ttgcaacaga gtgcttagtt     5940

acgtcactca tgctgatgtt cgtaagaaat aataaattac tggtttgctg aggattttat     6000

gtacgattat atcattgttg gttctggttt gtttggtgcc gtttgtgcga atgagttaaa     6060

aaagctaaac aaaaaagttt tagtgattga gaaaagaaat catatcggtg gaaatgcgta     6120

cacagaggac tgtgagggta tccagattca taaatatggt gcacatattt ttcataccaa     6180

tgataaatat atatgggatt acgttaatga tttagtagaa tttaatcgtt ttactaattc     6240

tccactggcg atttataaag acaaattatt caaccttcct tttaatatga atactttcca     6300

ccaaatgtgg ggagttaaag atcctcaaga agctcaaaat atcattaatg ctcagaaaaa     6360

aaagtatggt gacaaggtac ctgaaaattt ggaggagcag gcgatttcat tagttgggga     6420

ggacttatac caagcattga taaagggtta tacggagaag cagtggggaa gaagtgcaaa     6480

agaattgcct gcatttatta ttaagcgaat cccagtgaga tttacgtttg ataacaatta     6540

tttttccgat cgctatcaag gtattccggt gggaggctac actaagctta ttgaaaaaat     6600

gcttgaaggt gtggacgtaa aattaggcat tgattttttg aaagacaaag attctctagc     6660

gagtaaagcc catagaatca tctacactgg acccattgat cagtacttcg actataggtt     6720

tggagcgtta gaatatcgct ctttaaaatt tgagacggaa cgccatgaat ttccaaactt     6780

ccaagggaat gcagtaataa atttcactga tgctaatgta ccatatacca gaataattga     6840

gcataaacat tttgactatg ttgagacaaa gcatacggtt gttacaaaag aatatccatt     6900

agagtggaaa gttggcgacg aaccctacta tccagttaat gataataaaa acatggagct     6960

ttttaagaaa tatagagagt tagctagcag agaagacaag gttatatttg gcgggcgttt     7020

ggccgagtat aaatattatg atatgcatca agtgatatct gccgctcttt atcaagtgaa     7080

aaatataatg agtacggatt aatgatctat cttgtaatta gtgtctttct cattacagca     7140

tttatctgtt tatatcttaa gaaggatata ttttatccag ccgtatgcgt taatatcatc     7200

ttcgcactgg tcttattggg atatgaaata acgtcagata tatatgcttt tcagttaaat     7260

gacgctacgt tgatttttct actttgcaat gttttgacat ttaccctgtc atgtttattg     7320

acggaaagtg tattagatct aaatatcaga aaagtcaata atgctattta tagcatacca     7380

tcgaagaaag tgcataatgt aggcttgtta gttatttctt tttcgatgat atatatatgc     7440

atgaggttaa gtaactacca gttcgggact agcttactta gctatatgaa tttgataaga     7500

gatgctgatg ttgaagacac atcaagaaat ttctcagcat acatgcagcc aatcattcta     7560

actacttttg ctttatttat ttggtctaaa aaatttacta atacaaaggt aagtaaaaca     7620

tttactttac ttgtttttat tgtattcatc tttgcaatta tactgaatac tggtaagcaa     7680

attgtcttta tggttatcat ctcttatgca ttcatcgtag gtgttaatag agtaaaacat     7740

tatgtttatc ttattacagc tgtaggtgtt ctattctcct tgtatatgct ctttttacgt     7800

ggactgcctg gggggatggc atattatcta tccatgtatt tggtcagccc tataatcgcg     7860

tttcaggagt tttattttca gcaagtatct aactctgcca gttctcatgt cttttggttt     7920

tttgaaaggc tgatggggct attaacaggt ggagtctcta tgtcgttgca taaagaattt     7980

gtgtgggtgg gtttgccaac aaatgtttat actgcttttt cggattatgt ttatatttcc     8040

gcggagctaa gctatttgat gatggttatt catggctgta tttcaggtgt tttatggaga     8100

ttgtctcgaa attacatatc tgtgaaaata ttttattcat attttattta taccttttct     8160

ttcatttttt atcatgaaag cttcatgact aatattagca gttggataca aataactctt     8220

tgtatcatag tattctctca atttcttaag gcccagaaaa taaagtgaaa atgtattttt     8280

tgaatgattt aaatttctct agacgcgatg ctggatttaa agcaagaaaa gatgcactgg     8340

acattgcttc agattatgaa aacatttctg ttgttaacat tcctctatgg ggtggagtag     8400

tccagagaat tattagttct gttaagctta gtacatttct ctgcggtctt gaaaataaag     8460

atgttttaat tttcaatttc ccgatggcca aaccattttg gcatatattg tcattctttc     8520

accgccttct aaaatttaga atagtacctc tgattcatga tattgatgaa ttaagaggag     8580

gagggggtag tgattctgtg cggcttgcta cctgtgatat ggtcataagt cacaatccac     8640

aaatgacaaa gtaccttagt aaatatatgt ctcaggataa aatcaaagac ataaaaatat     8700

ttgattacct cgtctcatct gatgtggagc atcgagatgt tacggataag caacgagggg     8760

tcatatatgc tggcaacctt tctaggcata aatgttcttt catatatact gaaggatgcg     8820

attttactct ctttggtgtc aactatgaaa ataaagataa tcctaaatat cttggaagtt     8880

ttgatgctca atctccggaa aagattaacc tcccaggcat gcaatttgga ctcatttggg     8940

atggagattc tgtcgaaacc tgtagtggtg cctttggcga ctatttaaag tttaataacc     9000

ctcataagac atctctttat ctttcaatgg aacttccagt atttatatgg gataaagccg     9060

cccttgcgga tttcattgta gataatagaa taggatatgc agtgggatca atcaaagaaa     9120

tgcaagagat tgttgactcc atgacaatag aaacttataa gcaaattagt gagaatacaa     9180

aaattatttc tcagaaaatt cgaacaggaa gttacttcag ggatgttctt gaagaggtga     9240

tcgatgatct taaaactcgc taaacgatat ggtctctgtg gttttattcg gcttgttaga     9300

gatgtcttat tgactcgtgt attttaccgg aactgtagaa ttattcgatt tccctgctat     9360

attcgcaatg atggtagcat taattttggt gaaaatttca caagtggagt cggtctcagg     9420

ctggatgcat ttggacgtgg cgtgattttt ttttccgata atgtgcaagt taacgactat     9480

gttcatatcg cctcaattga gagcgttacg ataggtcggg atacgcttat tgcaagtaaa     9540

gtatttatta ccgatcataa tcacggttcc tttaagcact ctgatccaat gagttcgcca     9600

aatatacctc cagacatgcg cacgttggaa tcttcagctg ttgtaattgg ccagagggtt     9660

tggttgggtg agaatgtgac ggttttgcct ggaacaatta ttggtaatgg agtcgtagtc     9720

ggcgccaatt ctgttgttag aggttctatt cccgaaaata ctgtcattgc gggagtacca     9780

gcaaaaatca taaagaaata caatcatgag accaaattat gggaaaaagc atagtcgttg     9840

tttctgcggt caattttacc actggcggtc catttaccat tttgaaaaaa tttttggcag     9900

caactaataa taaagaaaat gtcagtttta tcgcattagt ccattctgct aaagagttaa     9960

aagaaagtta tccatgggtt aaattcattg agtttcctga ggttaaaggg tcgtggctaa    10020

aacgtttgca ctttgaatat gtagtttgta aaaaactttc aaaagagctg aatgctacgc    10080

attggatttg tctgcatgat attacggcca atgtcgtcac taaaaaaaga tatgtgtatt    10140

gtcataaccc tgcccctttt tataaaggaa ttttattccg tgaaattctt atggagccta    10200

gctttttctt atttaaaatg ctatacgggc tgatatataa aataaacatt aaaaaaaata    10260

ctgcagtgtt tgttcaacaa ttctggatga aagaaaaatt tatcaagaaa tattctataa    10320

ataacatcat tgtcagtcgg ccagaaatta aattatctga taaaagccaa cttactgatg    10380

atgattctca atttaagaat aacccttctg agttgacaat attttaccct gctgttccac    10440

gagtatttaa aaattacgag cttattatta gtgcagcaag gaaattgaaa gaacaatcca    10500

atattaaatt tctgcttact atcagtggta cagaaaatgc gtatgcaaaa tatattatca    10560

gtcttgcaga aggactggat aatgttcatt tcctcgggta cttggataaa gaaaaaatcg    10620

atcattgtta taatatttca gatatagttt gttttccctc taggttagaa acatggggat    10680

tgccgttgtc tgaggctaaa gagcgaggta agtgggtatt agcatcagat ttcccattta    10740

ctagagaaac tcttggtagt tatgaaaaga aagctttttt tgattctaat aacgatgaca    10800

tgttagttaa acttattatt gacttcaaaa aaggtaacct caaaaaagat atctctgatg    10860

caaatttcat ttatcgtaat gaaaatgtat tagttgggtt tgatgaacta gttaatttta    10920

ttactgaaga acattgaaat ggtatatata ataatcgttt cccacggaca tgaagactac    10980

atcaaaaaat tactcgaaaa tcttaatgct gacgatgagc actacaagat tatcgtacgc    11040

gacaacaaag actctctatt attgaaacaa atatgccagc attatgcagg cctggactat    11100

attagtggag gtgtatacgg ctttggtcat aataataata ttgcggtggc gtatgtaaag    11160

gaaaaatata gacccgcaga tgatgattac attttgtttt tgaatcccga tatcatcatg    11220

aagcatgatg atttgctgac atatattaaa tatgtcgaaa gtaagcgtta tgcttttagt    11280

acattatgcc tgttccgaga tgaagcgaaa tctttacatg attattccgt aagaaaattt    11340

cctgtgcttt ctgattttat tgtgtcattt atgttaggga ttaataaaac aaaaattcct    11400

aaagaaagta tctattctga tacggttgtt gattggtgcg caggatcatt tatgctggta    11460

cgtttttcag attttgtgcg tgtaaatggc ttcgatcaag gttactttat gtactgtgaa    11520

gatattgacc tgtgcttgag gcttagcctg gctggtgtca gacttcatta tgttcccgct    11580

tttcatgcga tacattatgc tcatcatgac aatcgaagtt ttttttcaaa agccttcaga    11640

tggcacttaa aaagtacttt tagatattta gccagaaaac gtattttatc aaatcgcaac    11700

tttgatcgaa tttcatcagt ttttcacccg taagagctcg gtacccgggc ctagggtgta    11760

ggctggagct gcttcgaagt tcctatactt tctagagaat aggaacttcg gaataggaac    11820

taaggaggat attcatatcc gtcgacggcg gccgccctgc aggcatgcaa gcttgatcca    11880

tatggatcgc tagcttaatt aaataaagcc gtaagcatat aagcatggat aagctattta    11940

tactttaata agtactttgt atacttattt gcgaacattc caggccgcga gcattcagcg    12000

cggtgatcac acctgacagg agtatgtaat gtccaagcaa cagatcggcg tagtcggtat    12060

ggcagtgatg ggacgcaacc ttgcgctcaa catcgaaagc cgtggttata ccgtctctat    12120

tttcaaccgt tcccgtgaga agacggaaga agtgattgcc gaaaatccag gcaagaaact    12180

ggttccttac tatacggtga aagagtttgt cgaatctctg gaaacgcctc gtcgcatcct    12240

gttaatggtg aaagcaggtg caggcacgga tgctgctatt gattccctca aaccatatct    12300

cgataaagga gacatcatca ttgatggtgg taacaccttc ttccaggaca ctattcgtcg    12360

taatcgtgag ctttcagcag agggctttaa cttcatcggt acgggtgttt ctggcggtga    12420

agagggggcg ctgaaaggtc cttctattat gcctggtggc cagaaagaag cctatgaatt    12480

ggtagcaccg atcctgacca aaatcgccgc cgtagctgaa gacggtgaac catgcgttac    12540

ctatattggt gccgatggcg caggtcacta tgtgaagatg gttcacaacg gtattgaata    12600

cggcgatatg cagctgattg ctgaagccta ttctctgctt aaaggtggcc tgaacctcac    12660

caacgaagaa ctggcgcaga cctttaccga gtggaataac ggtgaactga gcagttacct    12720

gatcgacatc accaaagata tcttcaccaa aaaagatgaa gacggtaact acctggttga    12780

tgtgatcctg gatgaagcgg ctaacaaagg tacgggtaaa tggaccagcc agagcgcgct    12840

ggatctcggc gaaccgctgt cgctgattac cgagtctgtg tttgcacgtt atatctcttc    12900

tctgaaagat cagcgtgttg ccgcatctaa agttctctct ggtccgcaag cacagccagc    12960

aggcgacaag gctgagttca tcgaaaaagt tcgtcgtgcg ctgtatctgg gcaaaatcgt    13020

ttcttacgcc cagggcttct ctcagctgcg tgctgcgtct gaagagtaca actgggatct    13080

gaactacggc gaaatcgcga agattttccg tgctggctgc atcatccgtg cgcagttcct    13140

gcaaaaaatc accgatgctt atgccgaaaa tccacagatc gctaacctgt tgctggctcc    13200

gtacttcaag caaattgccg atgactacca gcaggcgctg cgtgatgtcg ttgcttatgc    13260

agtacagaac ggtattccgg ttccgacctt ctccgcagcg gttgcctatt acgacagcta    13320

ccgtgctgct gttctgcctg cgaacctgat ccaggcacag cgtgactatt ttggtgcgca    13380

tacttataag cgtattgata aagaaggtgt gttccatacc gaatggctgg attaa         13435


<210>  17
<211>  13228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example O18A rfb locus nucleotide sequence - O18A-EPA production 
       strain BVEC-L-00559

<400>  17
atgacgaatt taaaagcagt tattcctgta gcgggtctcg ggatgcatat gttgcctgcc       60

actaaggcga tacccaaaga gatgctacca atcgtcgaca agccaatgat tcagtacatt      120

gttgacgaga ttgtggctgc agggatcaaa gaaatcctcc tggtaactca cgcgtccaag      180

aacgcggtcg aaaaccactt cgacacctct tatgagttag aatcactcct tgagcagcgc      240

gtgaagcgtc aactgctggc ggaagtacag tccatctgtc cgccgggcgt gaccattatg      300

aacgtgcgtc agggcgaacc tttaggttta ggccactcca ttttgtgtgc gcgacctgcc      360

attggtgaca acccatttgt cgtggtactg ccagacgttg tgatcgacga tgccagcgcc      420

gacccgctac gttacaacct tgctgccatg attgcacgtt tcaacgaaac gggccgcagc      480

caggtgctgg caaaacgtat gccgggtgac ctctctgaat actccgtcat ccagactaaa      540

gagccgctgg accgtgaggg taaagtcagc cgcattgttg aatttatcga aaaaccggat      600

cagccgcaga cgctggactc agacatcatg gccgtaggtc gctatgtgct ttctgccgat      660

atttggccgg aactggaacg tactcagcct ggtgcatggg gacgtattca gctgactgat      720

gctattgccg agctggcgaa aaaacaatcc gttgatgcaa tgctgatgac cggcgacagt      780

tacgactgcg gcaaaaaaat gggctatatg caggcgtttg tgaagtatgg cctacgcaac      840

ctgaaagaag gggcgaagtt ccgtaaaggt attgagaagc tgttaagcga ataatgaaaa      900

tctgaccgga tgtaacggtt gataagaaaa ttataacggc agtgaaaatt cgcagcaaaa      960

gtaatttgtt gcgaatcttc ctgccgttgt tttatataaa ccatcagaat aacaacgagt     1020

tagcagtagg gttttattca aagttttcca ggattttcct tgtttccaga gcggattggt     1080

aagacaatta gcgtttgaat ttttcgggtt tagcgcgagt gggtaacgct cgtcacatca     1140

taggcatgca tgcagtgctc tggtagctgt aaagccaggg gcggtagcgt gcattaatac     1200

ctctattaat caaactgaga gccgcttatt tcacagcatg ctctgaagta atatggaata     1260

aattaagtga aaatacttgt tactggtggc gcaggattta ttggttcagc tgtagttcgt     1320

cacattataa ataatacgca ggatagtgtt gttaatgtcg ataaattaac gtacgccgga     1380

aaccgggaat cacttgctga tgtttctgat tctgaacgct atgtttttga acatgcggat     1440

atttgcgatg cacctgcaat ggcacggatt tttgctcagc atcagccgga tgcagtgatg     1500

cacctggctg ctgaaagcca tgttgaccgt tcaattacag gccctgcggc atttattgaa     1560

accaatattg ttggtactta tgtccttttg gaagccgctc gcaattactg gtctgctctt     1620

gatagcgaca agaaaaatag cttccgtttt catcatattt ctactgacga agtctatggt     1680

gatttgcctc atccagatga agtaaataat acagaagaat tacccttatt tactgagacg     1740

acagcttacg cgccaagcag cccttattcc gcatccaaag catccagcga tcatttagtc     1800

cgcgcgtgga aacgtacata tggtttaccg acaattgtga ctaattgctc gaacaactat     1860

ggtccttatc atttcccgga aaagcttatt ccactggtta ttcttaatgc actggaaggt     1920

aaggcattac ctatttatgg caaaggagat cagatccgcg actggttgta tgttgaagat     1980

catgcgcgtg cgttatatac cgtcgtaacc gaaggtaaag cgggtgaaac ttataacatt     2040

ggtgggcaca acgaaaagaa aaacatcgat gtagtgctca ctatttgtga tttgctggat     2100

gagattgtac cgaaagagaa atcttatcgt gagcaaatca cttatgttgc tgatcgtccg     2160

ggacacgatc gccgctatgc tattgatgct gagaagattg gtcgcgcatt gggatggaaa     2220

ccacaggaaa cgtttgagag cgggattcgt aaaacggtgg aatggtacct gtccaataca     2280

aaatgggttg ataatgtgaa aagtggtgcc tatcaatcgt ggattgaaca gaactatgag     2340

ggccgccagt aatgaatatc ctcctttttg gcaaaacagg gcaggtaggt tgggaactac     2400

agcgtgctct ggcacctttg ggtaatttga ttgcttttga tgttcactct actgattatt     2460

gcggtgattt tagtaatcct gaaggtgtag ctgaaaccgt aagaagcatt cggccggata     2520

ttattgtcaa tgcagccgct cacaccgcag tagacaaagc agaatcagaa ccggagtttg     2580

cacaattaat taacgcaaca agtgtcgaag cgattgcgaa agcagcaaat gaagttggag     2640

cctgggttat ccattactcg actgattacg tcttccctgg aaatggcgat atgccatggc     2700

tggagacgga tgcaaccgca ccactaaatg tttacggtga aaccaagtta gccggagaaa     2760

aagcgttaca ggaatattgc gcgaagcatc ttattttccg gaccagctgg gtctatgcag     2820

gaaaaggaaa taacttcgcc aaaacgatgt tacgtctggc aaaagagcgt gaagaattag     2880

cggttattaa cgatcagttt ggtgcgccaa caggtgctga actgctggct gattgtacag     2940

cacatgccat tcgtgtcgca ctgaataaac cggatgtcgc aggcttgtac catttggtag     3000

ccagtggtac cacaacctgg tacgattatg ctgcgctggt ttttgaagag gcgcgcaaag     3060

caggcattcc ccttgcactc aacaagctca acgcagtacc aacaacagcc tatcctacac     3120

cagctcgtcg tccacataac tctcgcctta atacagaaaa atttcagcag aactttgcgc     3180

ttgtcttgcc tgactggcag gttggcgtga aacgaatgct caatgaatta tttacgacta     3240

cagcaattta atagtttttg catcttgttc gtgatggtgg agcaagatga attaaaagga     3300

atgatgaaat gaaaatgcgt aaaggtatta ttttagcggg tggttctggt acacgtcttt     3360

atcctgtgac tatggctgtc agtaaacagc tattacctat ttatgataaa ccgatgatct     3420

attacccgct ctctacactg atgttggcgg gtattcgcga tattttgatt atcagtacac     3480

ctcaggatac tcctcgtttt caacaattgc tgggtgacgg tagccagtgg ggcctgaatc     3540

ttcagtacaa agtgcaacct agcccagatg gcctcgcgca ggcatttatc atcggtgaag     3600

agtttattgg tggtgatgat tgtgctttgg ttcttggtga taatatcttt tacggtcacg     3660

atctgccgaa gctaatggag gccgctgtta acaaagaaag tggtgcaacg gtatttgcct     3720

atcacgttaa tgatccagaa cgctatggtg tcgttgagtt tgataaaaac ggtacggcaa     3780

tcagtctgga agaaaaaccg ttagaaccaa agagtaatta cgccgttaca ggtctgtact     3840

tttatgataa cgacgtggtt cagatggcga aaaacttgaa gccgtctgca cgtggtgagt     3900

tagaaattac agatattaac cgtatttatc ttgagcaggg acgtctgtct gtcgcgatga     3960

tggggcgtgg ctacgcgtgg ctggacacgg ggactcatca gagtctgata gaagcaagta     4020

attttattgc gacaattgaa gagcgccagg gattgaaggt ttcctgtcct gaagagattg     4080

catttcgtaa aggttttatt gatgttgagc aagtaagaaa attagctgta ccactaataa     4140

agaataatta tgggcagtat ctttataaaa tgacgaagga ttcaaattaa tgaatgtgat     4200

tagaactgaa attgaagatg tgctaattct ggagccaaga gtatttggtg atgatagagg     4260

tttcttttat gagagcttta atcaatcagc atttgaacat attctaggct atccggtcag     4320

ctttgttcaa gacaatcact cacgttcatc aaaaaatgta ctcagaggcc ttcactttca     4380

acgcggcgag tacgcacaag ataaacttgt acgctgcact catggagcag tttttgatgt     4440

tgctgttgat attcgaccca attcggtatc ctttggtaaa tgggttggtg ttctgctttc     4500

agctgataat aagcagcagt tgtggatacc aaaagggttt gctcatggct ttttggttct     4560

gtctgatatc gctgaatttc aatataaaac tacaaactat tatcatcctg aaagcgattg     4620

tggaatatgt tggaatgatg aacgcattgc aattgattgg ccccaaacat cagggttaat     4680

cctttcgcca aaagatgaaa ggctctttac gttagatgag cttatcagat taaaattaat     4740

tgcatgaggc cggccttaag gaggactagt cccggcgcgc catgagttta atcaaaaaca     4800

gtttttggaa cctttgcggg tatgtacttc cagctattgt gacactacca gctttgggta     4860

ttatggggcg aaaattaggc ccagaattat ttggtgtatt cactttggca ttagctgttg     4920

tgggttatgc aagcattttt gatgcaggcc ttactcgcgc agtgatacga gaagtcgcaa     4980

ttgaaaaaga taatgaagaa aataagttga aaattatttc ttcagcgaca gttgtaatta     5040

tttatttgag tttggccgcc tcactcttat tatttttttt tagtggtcat atcgcattgc     5100

tactgaacat tagtgagact ttttttcata atgtaagtgt ctcgcttaaa attctcgcag     5160

catccatacc attatttttg attactcaaa tatggttgtc aattttagaa ggtgaagaaa     5220

gatttggttt acttaatatc tacaaatcaa ttacgggagt gatattagca atctcaccgg     5280

cattatttat acttattaaa ccctctttga tgtatgcgat aataggctta gttctagcaa     5340

ggtttttatg ttttattttg gcttttataa tttgtcacga taaagtgctt aaagctaaac     5400

taacaatcga tataccaaca attaaaagat tgtttatgtt cggtggttgg attacagtaa     5460

gtaatatcat cagccctgtg ctatcatatt ttgataggtt tattgtttca aatcaacttg     5520

gggctgctaa tgttgctttt tatactgcac catcagaaat tatttctcgg cttagtataa     5580

ttccaggtgc gttttcaaga gccttatttc caagattagc taatgcaaat aattccgctg     5640

aaagatataa aacgaaaaga ttaattacaa tttcactttt aataatcatc acccctattt     5700

tttgtattgg cgtgttattt tcagagaaga taatggtttt atggatgggg gcatcatttt     5760

ttggtgagcc tggtttggta ttatcaatat tactgattgg ctttattttt aatggattgg     5820

cacaagtacc atttgccagt attcaatccc gaggtcatgc taagataact gcatttgttc     5880

atctcttaga gttgtttcct tatttattac ttttatttta cctcataaaa gcacatgggg     5940

ttgttggcgc gggtattgcg tggtcagtga ggatgatagt agattatata gcattaagtc     6000

ttttggacgg taagtatatt aataaataaa attcaaaatg caagttaata actcatggct     6060

ttatttgggt aggtgacaat ttataatgat atatatatta actttaactc ttcttctagt     6120

tatagccata atgttttctc ttctcggcac aaaaagtagg atcacatctc cattaccttt     6180

gcatttttta ccatggttac taactttaat tgtcgggata agtaattacg atcaatttta     6240

cgagtttaat gaaagaagct tttactcttt gttgatttgg tttacagtta tttttatatt     6300

ttatttcata ggggaactgg ttaattataa acgtgaaaat ataaatgttt attatggtct     6360

ttcacatatt aaatatgaat gtaaaaaata ttggatcatt gtcatcccaa tttcattata     6420

taccattttc gaaatatata tggttggtat ggggggagca gatggattct ttctcaattt     6480

acgtcttgca aatacattgg agggctatac gggtaaaaaa tttatcttaa tgcctgctgt     6540

atatcctcta atgatggcta tgttcgcaat tgtttgtcta acaaaaactt ccaaattaaa     6600

taaatactcc atttatttct ggatgttttt gtattgtatt ggcacaatgg gaaaattttc     6660

aatattaacg ccaatattga catatttaat tatttatgac ttcaaacata gattaaaagt     6720

aaaaaaaaca ataaagttta cattgttgat aattatatta gctttaactt tgcattttac     6780

acgtatggct gagaatgacc actcaacatt tttatctatt ttagggctct atatttattc     6840

accaataatt gctttaggcc agttgaatga agtaaatagt agtcattttg gtgagtatac     6900

gtttagattc atatatgcta taactaataa aattggcctt attaaagaat tgccagtaaa     6960

tactattctt gactattcat acgttcctgt accaacaaat gtatatactg cacttcaacc     7020

attttaccag gattttggtt atactggcat catatttgga gcagtattat acggactaat     7080

atatgtgagt ttatacacgg ccggtgttcg tggaaataat acacaggcat tactgattta     7140

cgcattgttt tcagttagca gtgcaacggc tttcttcgct gaaacgctag taacgaattt     7200

agctggaaat gtgatgttag tattatgtac catcttacta tggcgattta cagtaatatg     7260

caaaccagta cagtaaccat tctaatggcc acctacaatg gcgaggcctt catcaaaaat     7320

cagattttgt cactacaaca acaaacattt tctaactggc ggttatttat tcaggatgat     7380

gggtctacag acaatactat atctataata aaaaacttcc aaaaatctga ctccagaatt     7440

cggctagttg atgataattt gaaaggtcaa ggtgcaggaa aaaatttttt atcgctgata     7500

aagtacagcg agacagatta tacaatttat tgtgaccaag atgatatttg gttagaaaac     7560

aaaatatttg aattagtaaa gtatgcaaat gaaattaaat tgaatgtatc agatgcgcct     7620

tcgctagttt atgctgatgg ctatgcttat atggatggtg agggtacaat cgatttttct     7680

gggatatcta acaatcatgc tgatcaatta aaggattttc ttttttttaa tggtggatac     7740

caaggatgtt ctattatgtt caatcgtgca atgaccaaat ttcttctgaa ttatcgagga     7800

tttgtatatc tacatgacga tatcacaaca ttagctgcat acgctcttgg taaagtttat     7860

tttctcccga aataccttat gttatataga cagcacacga atgcggtaac tggtatcaaa     7920

acattccgca atggattgac ttctaaattt aaatcaccag taaactatct tttatcacga     7980

aaacattatc aggtaaaaaa atcttttttt gaatgtaaca gctctatctt atcagagacg     8040

aataaaaaag tttttttgga ttttatttca ttttgtgaat caaataataa atttacagat     8100

ttttttaagt tatggcgagg tgggtttaga ttaaataaca gtagaactaa attattatta     8160

aaattcttaa tacggagaaa atttagcgaa tgatttcaat acttacacct acttttaatc     8220

ggcaacatac tttatcaagg ctattcaatt ctcttatatt acaaactgat aaagattttg     8280

agtggataat aattgatgat ggtagtatag atgcaacagc ggtacttgta gaagatttta     8340

gaaaaaaatg tgattttgac ttgatttatt gctatcagga aaataatggt aagcccatgg     8400

ctttaaacgc tggtgttaaa gcttgtagag gcgattatat ctttattgtt gacagtgatg     8460

atgcactaac tcccgatgcc ataaaattaa ttaaagaatc aatacatgat tgcttatctg     8520

agaaggaaag tttcagcgga gtcggtttta gaaaagcata tataaaaggg gggattattg     8580

gtaatgattt aaataattct tcagaacata tatactattt aaatgcgact gagattagca     8640

atttaataaa tggtgatgtt gcatattgtt ttaaaaaaga aagtttggta aaaaatccat     8700

tcccccgtat agaagatgaa aaatttgttc cagaattata tatttggaat aaaataactg     8760

acaaggcgaa gattcgattt aacataagca aagttatata tctttgtgag tatcttgatg     8820

atggtctttc taaaaatttc cataaccagc ttaaaaaata cccaaagggg tttaagattt     8880

attacaaaga tcaaagaaaa cgagagaaaa cttatataaa aaaaacaaag atgctaatta     8940

gatatttgca atgttgttat tatgagaaaa taaaatgaaa atactatttg tcattacagg     9000

tttaggcctt ggaggtgctg agaagcaggt ttgtctttta gctgataaat taagtttaag     9060

cgggcaccat gtaaagatta tttcacttgg acatatgtct aataataaag tctttcctag     9120

cgaaaataat gttaatgtca ttaatgtaaa tatgtcaaaa aacatttctg gagttataaa     9180

aggttgtgtc agaattagag atgttatagc taatttcaaa ccagacattg tacacagtca     9240

tatgtttcat gcaaacatta tcactagatt gtctgtaatt ggaatcaaaa acagacctgg     9300

tattatatca actgcacata ataaaaatga aggtgggtat ttcagaatgc tcacatatag     9360

aataaccgat tgtttaagtg attgttgtac aaatgttagc aaagaagcag tggatgagtt     9420

tttacggata aaagccttta atcccgctaa agcaattact atgtataatg ggatagatac     9480

caataaattt aaatttgatt tattggcaag gagggaaatt cgagacggta ttaatataaa     9540

aaatgatgat atattattac ttgctgcagg tcgtttaacg ttagctaaag attatcctaa     9600

tttattgaat gcaatgactc tgcttcctga acactttaaa cttattatta ttggtgatgg     9660

tgaattgcgt gacgaaatta atatgcttat aaaaaaattg caattatcta atagggtgtc     9720

cttgttggga gttaaaaaaa atattgctcc ctatttttct gcatgtgata tttttgttct     9780

ctcttctcgt tgggaaggat ttggattagt cgtggcagaa gctatgtcat gtgagcgaat     9840

tgttgttggc acggattcag ggggagtaag agaagttatt ggtgacgatg attttcttgt     9900

acccatatct gattcaacac aacttgcaag caaaattgaa aaattgtctt tgagccagat     9960

acgtgatcac attggttttc ggaatcgtga gcgtatttta aaaaatttct caatagatac    10020

tattattatg cagtggcaag aactctatgg aactataatt tgctcaaaac atgaaaggta    10080

gatttatatt tggaacgtgt cttttgtttg aatttaattc aatctcaatt gagatttttg    10140

tatttcaaaa ataccatcat agctaacgat gattggtatt tattttaaga tgctttctat    10200

aaatatattg acgtttttaa tgcgccgaaa cgattgggct gggaacagag aagtaaaact    10260

gttttgagaa tgaagagttt ttgagatgtt tatggatatt aaaaattgat ccagtgaatt    10320

aattatttat aataaatcaa gatttaatgt taataaatga taatcttttc tgacactcat    10380

attaattatg agtggtacgt ttggtaaacg gtaaactatt atatgacagc tagaacaact    10440

aaagttttgc acttacaatt actcccactc ttaagtggcg ttcaaagggt aacattaaac    10500

gaaattagtg cgttatatac tgattatgat tatacactag tttgctcaaa aaaaggtcca    10560

ctaacaaaag cattgctgga atatgatgtc gattgtcatt gtatccccga acttacgaga    10620

gaaattaccg taaagaatga ttttaaagca ttgttcaagc tttataagtt cataaaaaaa    10680

gaaaaatttg acattgtgca tacacattct tcaaaaacag gtattttggg gcgagttgct    10740

gccaaattag cacgtgttgg aaaggtgatc cacactgtac atggtttttc ttttccagcc    10800

gcatctagta aaaaaagtta ttacctttat tttttcatgg aatggatagc aaagttcttt    10860

acggataagt taatcgtctt gaatgtagat gatgaatata tagcaataaa caaattaaaa    10920

ttcaagcggg ataaagtttt tttaattcct aatggagtag acactgataa gttttctcct    10980

ttagaaaata aaatttatag tagcaccttg aatctagtaa tggttggtag attatccaag    11040

caaaaagatc ctgagacatt attgcttgct gttgaaaaac tgctgaatga aaatgttaat    11100

gttaagctga cacttgtagg agatggtgaa ctaaaagaac agttagaaag caggttcaaa    11160

cggcaagatg gacgtataat ttttcatgga tggtcagata acattgttaa tattttaaaa    11220

gttaatgatc tttttatatt accttctctt tgggagggta tgccattagc aattttagaa    11280

gcattgagct gtggacttcc atgtatagtc actaatattc caggtaataa tagcttaata    11340

gaagatggct ataatggttg tttgtttgaa attagagatt gtcagttatt atctcaaaaa    11400

atcatgtcat atgttggtaa gccagaactg attgcacagc aatctaccaa tgcacgatca    11460

tttattctga aaaattatgg attagttaaa agaaataata aggtcagaca gctatatgat    11520

aattaagagc tcggtacccg ggcctagggt gtaggctgga gctgcttcga agttcctata    11580

ctttctagag aataggaact tcggaatagg aactaaggag gatattcata tccgtcgacg    11640

gcggccgccc tgcaggcatg caagcttgat ccatatggat cgctagctta attaaataaa    11700

gccgtaagca tataagcatg gataagctat ttatacttta ataagtactt tgtatactta    11760

tttgcgaaca ttccaggccg cgagcattca gcgcggtgat cacacctgac aggagtatgt    11820

aatgtccaag caacagatcg gcgtagtcgg tatggcagtg atgggacgca accttgcgct    11880

caacatcgaa agccgtggtt ataccgtctc tattttcaac cgttcccgtg agaagacgga    11940

agaagtgatt gccgaaaatc caggcaagaa actggttcct tactatacgg tgaaagagtt    12000

tgtcgaatct ctggaaacgc ctcgtcgcat cctgttaatg gtgaaagcag gtgcaggcac    12060

ggatgctgct attgattccc tcaaaccata tctcgataaa ggagacatca tcattgatgg    12120

tggtaacacc ttcttccagg acactattcg tcgtaatcgt gagctttcag cagagggctt    12180

taacttcatc ggtaccggtg tttctggcgg tgaagagggg gcgctgaaag gtccttctat    12240

tatgcctggt ggccagaaag aagcctatga attggtagca ccgatcctga ccaaaatcgc    12300

cgccgtagct gaagacggtg aaccatgcgt tacctatatt ggtgccgatg gcgcaggtca    12360

ctatgtgaag atggttcaca acggtattga atacggcgat atgcagctga ttgctgaagc    12420

ctattctctg cttaaaggtg gcctgaacct caccaacgaa gaactggcgc agacctttac    12480

cgagtggaat aacggtgaac tgagcagtta cctgatcgac atcaccaaag atatcttcac    12540

caaaaaagat gaagacggta actacctggt tgatgtgatc ctggatgaag cggctaacaa    12600

aggtacgggt aaatggacca gccagagcgc gctggatctc ggcgaaccgc tgtcgctgat    12660

taccgagtct gtgtttgcac gttatatctc ttctctgaaa gatcagcgtg ttgccgcatc    12720

taaagttctc tctggtccgc aagcacagcc agcaggcgac aaggctgagt tcatcgaaaa    12780

agttcgtcgt gcgctgtatc tgggcaaaat cgtttcttac gcccagggct tctctcagct    12840

gcgtgctgcg tctgaagagt acaactggga tctgaactac ggcgaaatcg cgaagatttt    12900

ccgtgctggc tgcatcatcc gtgcgcagtt cctgcaaaaa atcaccgatg cttatgccga    12960

aaatccacag atcgctaacc tgttgctggc tccgtacttc aagcaaattg ccgatgacta    13020

ccagcaggcg ctgcgtgatg tcgttgctta tgcagtacag aacggtattc cggttccgac    13080

cttctccgca gcggttgcct attacgacag ctaccgtgct gctgttctgc ctgcgaacct    13140

gatccaggca cagcgtgact attttggtgc gcatacttat aagcgtattg ataaagaagg    13200

tgtgttccat accgaatggc tggattaa                                       13228


<210>  18
<211>  13554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example O25B rfb locus nucleotide sequence - O25B-EPA production 
       strain stGVXN4459

<400>  18
atgacgaatt taaaagcagt tattcctgta gcgggtctcg ggatgcatat gttgcctgcc       60

actaaggcga tacccaaaga gatgctacca atcgtcgaca agccaatgat tcagtacatt      120

gttgacgaga ttgtggctgc agggatcaaa gaaatcctcc tggtaactca cgcgtccaag      180

aacgcggtcg aaaaccactt cgacacctct tatgagttag aatcactcct tgagcagcgc      240

gtgaagcgtc aactgctggc ggaagtacag tccatctgtc cgccgggcgt gaccattatg      300

aacgtgcgtc agggcgaacc tttaggttta ggccactcca ttttgtgtgc gcgacctgcc      360

attggtgaca acccatttgt cgtggtactg ccagacgttg tgatcgacga tgccagcgcc      420

gacccgctac gttacaacct tgctgccatg attgcacgtt tcaacgaaac gggccgcagc      480

caggtgctgg caaaacgtat gccgggtgac ctctctgaat actccgtcat ccagactaaa      540

gagccgctgg accgtgaggg taaagtcagc cgcattgttg aatttatcga aaaaccggat      600

cagccgcaga cgctggactc agacatcatg gccgtaggtc gctatgtgct ttctgccgat      660

atttggccgg aactggaacg tactcagcct ggtgcatggg gacgtattca gctgactgat      720

gctattgccg agctggcgaa aaaacaatcc gttgatgcaa tgctgatgac cggcgacagt      780

tacgactgcg gcaaaaaaat gggctatatg caggcgtttg tgaagtatgg cctacgcaac      840

ctgaaagaag gggcgaagtt ccgtaaaggt attgagaagc tgttaagcga ataatgaaaa      900

tctgaccgga tgtaacggtt gataagaaaa ttataacggc agtgaaaatt cgcagcaaaa      960

gtaatttgtt gcgaatcttc ctgccgttgt tttatataaa ccatcagaat aacaacgagt     1020

tagcagtagg gttttattca aagttttcca ggattttcct tgtttccaga gcggattggt     1080

aagacaatta gcgtttgaat ttttcgggtt tagcgcgagt gggtaacgct cgtcacatca     1140

taggcatgca tgcagtgctc tggtagctgt aaagccaggg gcggtagcgt gcattaatac     1200

ctctattaat caaactgaga gccgcttatt tcacagcatg ctctgaagta atatggaata     1260

aattaagcta gcagtgaaga tacttgttac tggtggcgca ggatttattg gttctgctgt     1320

tgttcgtcac ataataaata atacgcaaga tagtgttgtt aatgtcgata aattaacata     1380

cgccggaaac ctggaatcac ttgcagatgt ttctgattct gaacgctatt tctttgaaca     1440

tgcggatatt tgtgatgcag ctgcaatggc acggattttt gctcagcatc agccggatgc     1500

agtgatgcac ctggcagctg aaagccatgt tgaccgttca attacaggcc ctgcggcatt     1560

tattgaaacc aatattgtgg gtacttatgt ccttttagaa gcggctcgga attattggtc     1620

tggtctggat gatgaaaaga aaaaaaactt ccgttttcat catatttcta ctgatgaggt     1680

gtatggtgac ttaccccatc cggatgaagt aaatagcaat gaaacgttgc cgctatttac     1740

ggaaacgaca gcatacgcgc caagtagtcc atattctgct tctaaagctt ccagcgatca     1800

tttggttcgc gcatggaaac gtacttatgg tttaccgacc attgtgacta attgctcgaa     1860

caactatggt ccttatcatt tcccggaaaa gcttattcca ctggttattc ttaattcact     1920

ggaaggtaag gcattaccta tttatggcaa aggagatcag atccgcgact ggttgtatgt     1980

agaggatcat gctcgagcgt tatataccgt cgtaaccgaa ggtaaagcgg gcgaaactta     2040

taacattggt ggacacaacg aaaagaaaaa catcgacgta gtgttcacta tttgtgattt     2100

gttggatgag atagtcccga aagagaaatc ttaccgcgag caaattactt atgttaccga     2160

tcgtccggga cacgatcgcc gttatgcgat tgatgctgag aagattggtc gcgaattggg     2220

atggaaacca caggaaacgt ttgagagtgg gattcgtaaa acggtggaat ggtacctgtc     2280

caatacaaaa tgggttgata atgtgaaaag tggtgcctat caatcgtgga ttgaacagaa     2340

ctatgagggc cgccagtaat gaatatcctc ctttttggca aaacagggca ggtaggttgg     2400

gaactacagc gtgctctggc acctctgggt aatttgattg ctcttgatgt tcactccact     2460

gattactgtg gtgattttag taatcctgaa ggtgtagctg aaaccgtaag aagcattcgg     2520

cctgatatta ttgtcaacgc agccgctcac accgcagtag acaaagcaga atcagaaccg     2580

aagtttgcac aattactgaa cgcgacgagt gtcgaagcga tcgcgaaagc agccaatgaa     2640

gtcggcgcct gggttattca ctactctact gactacgtat ttccggggac cggtgaaata     2700

ccatggcagg aggaggatgc aaccgcaccg ctaaatgttt acggtgaaac caagttagcg     2760

ggagaaaaag cattacaaga gcattgtgcg aagcacctta ttttccggac cagctgggtc     2820

tatgcaggta aaggaaataa cttcgccaaa acaatgttgc gtctggcaaa agagcgtgaa     2880

gaattagccg ttattaatga tcagtttggt gcgccaactg gcgcagagtt actggctgat     2940

tgtacggcac atgctattcg tgtggcactg aataaaccgg aagtcgcagg cttgtaccat     3000

ctggtagcta gtggtaccac aacgtggcac gattatgctg cgctggtttt tgaagaggcg     3060

cgcaaagcag gcattcccct tgcactcaac aagctcaacg cagtaccaac aacagcctat     3120

cctacaccag ctcgtcgtcc acataactct cgccttaata cagaaaaatt tcagcagaac     3180

tttgcgcttg tcttgcctga ctggcaggtt ggcgtgaaac gaatgcttaa cgaattattt     3240

acgactacag caatttaata gtttttgcat cttgttcgta atggtggagc aagatgtatt     3300

aaaaggaatg atgaaatgaa aacgcgtaaa ggtattattt tggcgggtgg ttctggtact     3360

cgtctttatc ctgtgacgat ggccgtcagt aaacagctgt taccgattta tgataaaccg     3420

atgatctatt acccgctctc tacactgatg ttagcgggta ttcgcgatat tctgattatc     3480

agtacaccac aggatactcc tcgttttcaa caactgctgg gtgacgggag ccagtggggc     3540

ctgaatcttc agtacaaagt gcaaccgagt ccggatggtc ttgcgcaggc gtttattatc     3600

ggtgaagagt ttattggtgg tgatgattgt gctttggtac ttggtgataa tatcttctac     3660

ggccacgacc tgccgaagtt aatggacgta gctgttaaca aagaaagtgg tgcaacggta     3720

tttgcctatc acgttaatga tcctgaacgt tatggtgtcg tggagtttga taataacggt     3780

actgcaatta gcctggaaga aaaaccgctg gaaccaaaaa gtaactatgc ggttactggg     3840

ctttatttct atgacaatga cgttgtggaa atggcgaaaa accttaagcc ttctgcccga     3900

ggtgaactgg aaattaccga tattaaccgt atttatatgg aacaaggacg tttgtctgtc     3960

gctatgatgg ggcgtggcta tgcatggctg gatacaggga cgcatcaaag tcttattgaa     4020

gcaagcaact tcattgccac cattgaagag cgccagggac taaaggtttc ctgtccggaa     4080

gaaattgctt atcgtaaagg gtttattgat gctgagcagg taaaagtatt agccgaaccg     4140

ttgaagaaaa atgcttatgg tcagtatctg ctcaaaatga ttaaaggtta ttaataagat     4200

gaacgtaatt aaaactgaaa ttcctgatgt gctgattttt gaaccaaaag tttttgggga     4260

tgaacgtggc ttcttttttg agagttttaa tcagaggatt tttgaagaag cagtaggtcg     4320

taaggttgag tttgttcagg ataaccattc taagtccagt aaaggtgttt tacgtggtct     4380

tcattatcag ttagaacctt atgctcaagg aaaactggtg cgctgtgttg ttggcgaggt     4440

ttttgatgtt gcggttgata ttcgtaaatc gtcacctaca tttgggaaat gggttggggt     4500

gaatttgtct gctgagaata agcgtcagtt gtggattcct gagggatttg cacatggttt     4560

tttggtgctg agtgatttag cagaagtttt atataaaacg aatcaatatt atgctccatc     4620

acatgaaaaa aatattatat ggaatgacct cttgcttaat attaaatggc cgagcacagc     4680

actgatcact ctgtctgata aggatgcaaa tggggaaaga tttgaactaa gtgagttttg     4740

aaatgtctct cttaaaacat agtatatgga atgttgcggg ctactttata ccaacattaa     4800

ttgcaattcc cgcctttgga ttaattgcga ggaaaattgg tgtagaacta tttggtttgt     4860

atacgttagc aatgattttt atagggtatg caagtatatt tgatgctggg ttaacaagag     4920

ctgttgtgcg tgaaatagca ttactaaaaa acagagtgga cgattgtaat acgataatag     4980

taacttctat tatcgctgtg atatttttag ggtttatcgg aggcggggga gtgtttctgc     5040

ttaaaggcga tattattgaa ctgttaaata tctcaccaat atattacgcc gattcgataa     5100

agtctctagt attattatca tctctgatac ctgtattctt agtcacgcaa atactattag     5160

cagagcttga gggtcgggaa tattttggga ttctaaatat acaaaaaagt gtagggaatt     5220

ctttaattgc agggttacct gcattatttg ttttaattaa tcaaacgctt ttttctgcaa     5280

ttattggtgt agcgattgca agagttatat gcttgtggtt aagctacatt atgagcaggg     5340

aaagaataac tatcgatatc tcattttttt caataactgt tttaaagcgg ttatttagat     5400

atggcgggtg ggtaactata agtaacataa tatctcctat attagcgagt atggatagat     5460

ttattctatc ccatatccag ggagcatcaa aaatatcatt ctatacagtc cctaatgagc     5520

tggtaactag gcttggaata gttccaggct ctcttgggaa agctgttttt ccaaaattaa     5580

gtcatgcaag gaattttaca gcgtcatatg cagagcaaaa aaaagcttat atattaatga     5640

ctgtcattgt aatgcctttg gttttatttg tatattatta cgcaaagttt attttaacat     5700

tgtggatggg ggctgagtat gcagggattt cggtcgaaat attacggatt atgcttatag     5760

ggtatatttt taactgttat tcacaaatct cttttgccaa catacaggcc tttggaaaag     5820

caaaatacac tgcatacatc catatgatgg aatttattcc ttatttgata atgttatata     5880

taatttcaaa ggaatatggg gttattggtg ttgcgtggtt atggacaatt cgagtaataa     5940

ttgatttttt gatgctttta tatatgagtt atcgttgtaa taatcttatg aaaaaagggt     6000

agcctgatga tatatattgt ggtattaaat tggaatgggg ctatagatac cattaattgt     6060

gttaaaagtt taatggattt aaatgttagc gattataaaa ttatcattgt tgataactgt     6120

tctatggata actcatatga tactataaaa gaaaatctta attcattata tattgctgat     6180

aaaagtatca ttgaggtgaa gtatgaggat agaaataaat ataaaacctt agaaaacgat     6240

aaaatcatat taatacaatc tccgcaaaat aatgggtacg caagtggtaa taatattggc     6300

atagagttcg ctcttaatca ggagaatatg aaatacgtct gggttctgaa taatgatact     6360

gaagtggata aagaggcttt aactcattta attagtaaat gtgattcaga taaaagtata     6420

gggatttgcg gttctcgttt agtctatttt gccgacagag agatgcagca aggactaggt     6480

ggggtgcata acaaatggtt atgcactaca aaaaattatg aaatgggaag attagtttcc     6540

aaaaaatatg atgatgaagt cattagtaat gatatagatt atataattgg cgcatcgatg     6600

tttttctcta gagaatgttt ggaaacagtt ggattgatga atgaagaata ttttttatac     6660

tatgaagagt tagatatttg cctcagagca aaagcaaaga actttaaatt aggtatttgc     6720

tcagaaagtt tggtttatca taaaataggt gcaagtactg atgggggaaa gagcatgatg     6780

gctgatcttt gctcaataaa aaataggctg gtcattacag aaaggtttta tccccaatat     6840

tattggacgg tatggttgtc actttttgtt gtagcattta accgtgctag aagaggtgag     6900

tttaataaga tgaaaagatg tttgaatgtt atgtttaact tcaaacgaaa caaaggtagc     6960

aaatgccatt agaatatgca cttaatcatg gtgttaataa atctatagtt tgatatgtta     7020

ttaaagggta tttaatgaaa gtggcttttt tatctgctta tgatccacta tctacatcca     7080

gttggtctgg cacaccttat tatatgctaa aggcattatc gaagagaaat atttccattg     7140

aaatattagg accggtaaat agctatatga tatacatgtt aaaagtatat aaattaatat     7200

taaggtgttt cggaaaagaa tatgattata gtcattcgaa gttgctttcc aggtattacg     7260

gtagaatatt cggtaggaaa ttaaaaaaaa ttgatggttt ggattttatt atcgcacctg     7320

caggttcctc acaaattgct tttttaaaaa caaccatacc aataatatat ctatcggata     7380

caacatatga tcaattaaaa agctattatc cgaatttaaa taaaaaaaca attataaatg     7440

atgaggatgc aagtttaatc gaacgcaagg ctattgaaaa agcaacagta gtatctttcc     7500

catctaaatg ggcaatggat ttttgcagga attattacag attagatttt gataaattag     7560

ttgaaatacc atggggggct aatttatttg atgatattca ctttgctaat aaaaatataa     7620

ttcaaaagaa tagttatact tgtcttttct tgggagttga ttgggaaaga aaaggtggga     7680

aaacagcctt gaaagcaatt gaatatgtaa ggcagttata tgggatcgat gttagactaa     7740

aaatttgtgg atgtactccg aatcaaaaga ttttacctac ttgggttgaa ttaattgata     7800

aagtagataa aaataacgtt gacgaatatc agaaattcat cgatgtgtta tctaacgctg     7860

atatacttct tttaccaacc attgctgaat gttatggaat ggtattttgt gaagctgctg     7920

cttttggatt gcctgttgtc gctacagata caggtggagt cagttctata gttatcaacg     7980

aaaggacggg gatattaatt aaagacccgt tagactataa gcactttgga aatgcaattc     8040

ataaaataat tagttccgta gagacttatc aaaactactc ccaaaacgca agaattagat     8100

ataataatat attgcattgg gacaattggg ctaaaaagat aattgagatt atgtatgagc     8160

ataagaatag aagaatcaaa tagcacaaaa agaattatat gtttatttat actttttctt     8220

gttttccctg attttttgtt ttatacatta ggggttgata attttagcat ttcaacgata     8280

atctcaatta cattgctttt tgttttttta agagctaaaa atatttgcaa agataatttt     8340

ctaataatag tagcgttatt catattgttg tgttttaact gtttgttaag tatgctattt     8400

aatattgaac aggctttaac atttaaagtt gtactttcaa tatatagcat cttaataatg     8460

gcatacgtct cctcttgtta tgcacagacg ttgtggttat gttctgaaga aatacttaag     8520

agatccgtct tttatttgtt cgcatttctt tgccttattg gcattataag tattctttta     8580

cagaagactg agattataca tgataaaagt atgattcttt ttcctgaacc atcagcattt     8640

gcattggttt ttatacctat cttttcattt tgtttatact atacaagagg gggggggcta     8700

ctattgctct atatattatc tttgggtatt gcgttaggta tccagaattt aacaatgttg     8760

gtaggcattg tgattagtgt ttttgtgatg aaaaaaataa ctataaggca aactattgtt     8820

atacttttgg gggcatggat tttttccatg atattaagtg atttagacat ttcttactat     8880

acatcgcggc ttgattttaa aaatactacg aacctatcag tgcttgtata tctttcagga     8940

attgaaagag ctttcttgaa ttttattaca agttatggtc ttggtattgg ttttcaacaa     9000

atgggagtga atggggagat aggaatatat caacaaattt tagctgaact tgatgcccct     9060

atgttaaata tatacgatgg ctcatttatt tcttctaagt taatatctga gtttggggtt     9120

attggtgcat taatgtgtat tttctatttt ttttattttt cccgatttta tctgcgtttc     9180

aaaaaaagta agagatattc accgcagtat attttagcat atagcttcta catgtgtttc     9240

ttcatccctc tttttatacg tggtgctggt tatataaacc cctatgtgtt tatgttattt     9300

tcatcaatat ttttgtgcaa atatcacgct aaaaatatct tgatgaaatc taatgtccag     9360

atagctatat aatagtagat tatattatca ttatcacgta aattacatat taatagcata     9420

tatgataact aggacataaa taatgtgcat taaaaaaaaa cttaagttaa ttaaacgata     9480

tggcctttat ggtggtctta ggcttcttaa agatatattc ttaacaaaat ttttattttg     9540

ttcaaatgtt aggattatta gatttccatg ttatattaga aaagatggaa gtgttagttt     9600

tggaaaaggt tttacatcag gtgtaggatt acgagttgat gcatttatgg atgccgtagt     9660

ttccattgga gaaaatgttc aaattaatga ctatgttcac atcgcggcta ttaataatgt     9720

cattattggt agagatacat taatagcaag taaagtattt attagtgatc ataatcatgg     9780

tattttttct aaatccgata tccatagttc accaactatt attccttcgt ctaggcccct     9840

tgaatctgca cctgtgtata ttggagagcg tgtgtggatt ggcgaaaatg tgacaatatt     9900

accaggtgcg tgtataggta atggtgtagt tattggcgca aacagtgttg ttcgtggtga     9960

gattcctaat aatgtgatca ttgctggtgt tccagctaaa attgttaaaa aatataacta    10020

tgagcgtatg caatgggaaa gaatatagtt gtaatatcgg ctgttaattt tacaaccgga    10080

ggccccttta ccgtactaaa aaatgtgctt acagcaacta aagatagagc cgaatgtaaa    10140

tttattgcac tggttcatag ctctgctgaa ctaatggaat tatttccgtg ggttgaattt    10200

atagagtatc cagaagtcaa gtcttcgtgg gttaaaagat tatatttcga atatataact    10260

tgcaatagat tatctaaggt gattaaggca actcattggg tatgcttaca tgatattaca    10320

gcaaatgtta gtgtacccta tagatttgtt tattgccaca atcctgcacc gttctataaa    10380

tatttaagct atcgagatat tataggagaa cctaaatttt atctttttta tcttttttat    10440

gggcttttat acaatatcaa tataaaaaag aacacagcag tttttgttca gcagcagtgg    10500

ctaaaaaaag aattcgaaaa aaaatataag ttaaagaatg ttgttgttag tcgccctgaa    10560

gatatttgcc cttttgaaag tgatggtttg gtaagaaata ataataaaaa ggatgtgagg    10620

atattttacc cagcagtgcc ccgtatattt aaaaactttg aagttatcat acgtgctgca    10680

caaatattac aagataaaaa tattcatttt tatcttactt ttgatggtac tgaaaataag    10740

tatgcaaaaa gaatatataa attagcttcc gaactgaaaa atgtacattt cctcggttac    10800

cttaatgcaa ccgagatggt taacttttat caagattcag atattatttg tttcccatcg    10860

aaactagaaa cgtggggatt accattatca gaagctaaaa catacaaaaa atggatattt    10920

gcggcagact taccttatgc tcatgaagtt ttatataact attcaaaaac tagatatttt    10980

ccatttgacg atgagaaaat acttgttcgc tacatattag agtacacaag taaaaatatg    11040

catgaagata taaaaaatag tagggtgaat tttaataatg atgcattgac tggttttgaa    11100

cagtttattg aatatatcct caaggggaac tgacgtggtt tatattataa tcgtttcaca    11160

tggccatgat gactatatag aaaatctttt attaaattta aagttgccct ctggaagatt    11220

taaaataata gttcgtgata acaaaagttc aatggtttta aaaaaaacat gcgaaaaaaa    11280

ttgcgtaacc tatttgcatg gagggcaata tggatttgga cataataata acatagcagt    11340

gtcatatata attaataact tcatgattat gaataatgat tattttctct ttcttaaccc    11400

cgatgtattc ataaccagtg aaagtttgat taattatgtt gattatataa ttagtaatga    11460

ttataagttt agcacattat gtctttatcg agattttact aaaagcaaac atgattattc    11520

aatacggagt tttccaactt tatatgattt tctttgttct tttttattgg gggtgaataa    11580

aagtaaaatt aagaaggaaa atatactttc tgatactgta gttgattggt gtgctggctc    11640

atttatgctt attcatgctt taagtttctt aaatgtgaat ggttttgatc aaaaatattt    11700

tatgtattgt gaagatattg acctttgtat gcgtttaaaa ttaagtggag tagatcttta    11760

ctatactccc cattttgatg ctattcatta tgcgcagcat gaaaatagaa gaatatttac    11820

taaagcattt cgatggcata taaggagtat tacgcgctac atattacgga aaccaattct    11880

ttcttataaa aactatagaa aaattacatc cgaactggta aagtgattaa ggatccgtgt    11940

aggctggagc tgcttcgaag ttcctatact ttctagagaa taggaacttc ggaataggaa    12000

ctaaggagga tattcatatg gataaagccg taagcatata agcatggata agctatttat    12060

actttaataa gtactttgta tacttatttg cgaacattcc aggccgcgag cattcagcgc    12120

ggtgatcaca cctgacagga gtatgtaatg tccaagcaac agatcggcgt agtcggtatg    12180

gcagtgatgg gacgcaacct tgcgctcaac atcgaaagcc gtggttatac cgtctctatt    12240

ttcaaccgtt cccgtgagaa gacggaagaa gtgattgccg aaaatccagg caagaaactg    12300

gttccttact atacggtgaa agagtttgtc gaatctctgg aaacgcctcg tcgcatcctg    12360

ttaatggtga aagcaggtgc aggcacggat gctgctattg attccctcaa accatatctc    12420

gataaaggag acatcatcat tgatggtggt aacaccttct tccaggacac tattcgtcgt    12480

aatcgtgagc tttcagcaga gggctttaac ttcatcggta ccggtgtttc tggcggtgaa    12540

gagggggcgc tgaaaggtcc ttctattatg cctggtggcc agaaagaagc ctatgaattg    12600

gtagcaccga tcctgaccaa aatcgccgcc gtagctgaag acggtgaacc atgcgttacc    12660

tatattggtg ccgatggcgc aggtcactat gtgaagatgg ttcacaacgg tattgaatac    12720

ggcgatatgc agctgattgc tgaagcctat tctctgctta aaggtggcct gaacctcacc    12780

aacgaagaac tggcgcagac ctttaccgag tggaataacg gtgaactgag cagttacctg    12840

atcgacatca ccaaagatat cttcaccaaa aaagatgaag acggtaacta cctggttgat    12900

gtgatcctgg atgaagcggc taacaaaggt accggtaaat ggaccagcca gagcgcgctg    12960

gatctcggcg aaccgctgtc gctgattacc gagtctgtgt ttgcacgtta tatctcttct    13020

ctgaaagatc agcgtgttgc cgcatctaaa gttctctctg gtccgcaagc acagccagca    13080

ggcgacaagg ctgagttcat cgaaaaagtt cgtcgtgcgc tgtatctggg caaaatcgtt    13140

tcttacgccc agggcttctc tcagctgcgt gctgcgtctg aagagtacaa ctgggatctg    13200

aactacggcg aaatcgcgaa gattttccgt gctggctgca tcatccgtgc gcagttcctg    13260

cagaaaatca ccgatgctta tgccgaaaat ccacagatcg ctaacctgtt gctggctccg    13320

tacttcaagc aaattgccga tgactaccag caggcgctgc gtgatgtcgt tgcttatgca    13380

gtacagaacg gtattccggt tccgaccttc tccgcagcgg ttgcctatta cgacagctac    13440

cgtgctgctg ttctgcctgc gaacctgatc caggcacagc gtgactattt tggtgcgcat    13500

acttataagc gtattgataa agaaggtgtg ttccataccg aatggctgga ttaa          13554


<210>  19
<211>  15197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example O75 rfb locus nucleotide sequence - O75-EPA production 
       strain stLMTB11737

<400>  19
atgacgaatt taaaagcagt tattcctgta gcgggtctcg ggatgcatat gttgcctgcc       60

actaaggcga tacccaaaga gatgctacca atcgtcgaca agccaatgat tcagtacatt      120

gttgacgaga ttgtggctgc agggatcaaa gaaatcctcc tggtaactca cgcgtccaag      180

aacgcggtcg aaaaccactt cgacacctct tatgagttag aatcactcct tgagcagcgc      240

gtgaagcgtc aactgctggc ggaagtacag tccatctgtc cgccgggcgt gaccattatg      300

aacgtgcgtc agggcgaacc tttaggttta ggccactcca ttttgtgtgc gcgacctgcc      360

attggtgaca acccatttgt cgtggtactg ccagacgttg tgatcgacga tgccagcgcc      420

gacccgctac gttacaacct tgctgccatg attgcacgtt tcaacgaaac gggccgcagc      480

caggtgctgg caaaacgtat gccgggtgac ctctctgaat actccgtcat ccagactaaa      540

gagccgctgg accgtgaggg taaagtcagc cgcattgttg aatttatcga aaaaccggat      600

cagccgcaga cgctggactc agacatcatg gccgtaggtc gctatgtgct ttctgccgat      660

atttggccgg aactggaacg tactcagcct ggtgcatggg gacgtattca gctgactgat      720

gctattgccg agctggcgaa aaaacaatcc gttgatgcaa tgctgatgac cggcgacagt      780

tacgactgcg gcaaaaaaat gggctatatg caggcgtttg tgaagtatgg cctacgcaac      840

ctgaaagaag gggcgaagtt ccgtaaaggt attgagaagc tgttaagcga ataatgaaaa      900

tctgaccgga tgtaacggtt gataagaaaa ttataacggc agtgaaaatt cgcagcaaaa      960

gtaatttgtt gcgaatcttc ctgccgttgt tttatataaa ccatcagaat aacaacgagt     1020

tagcagtagg gttttattca aagttttcca ggattttcct tgtttccaga gcggattggt     1080

aagacaatta gcgtttgaat ttttcgggtt tagcgcgagt gggtaacgct cgtcacatca     1140

taggcatgca tgcagtgctc tggtagctgt aaagccaggg gcggtagcgt gcattaatac     1200

ctctattaat caaactgaga gccgcttatt tcacagcatg ctctgaagta atatggaata     1260

aattaagcta gcagtgaaga tacttgttac tggtggcgca ggatttattg gttctgctgt     1320

tgttcgtcac ataataaata atacgcaaga tagtgttgtt aatgtcgata aattaacata     1380

cgccggaaac ctggaatcgc tcgctgaaat ttctgattct gaacgttatt catttgagca     1440

tgcagatatc tgcgatgccg aagcgatggc tcgtattttc gcacagcacc agccagacgc     1500

ggtgatgcac ctggcagcag agagccacgt tgaccgctca ataactggcc ctgcggcatt     1560

tattgaaacc aatattgtgg gtacttatgt tcttttagaa gcggcgcgca attattggtc     1620

tggtctggat gatgaaaaga aaaaaaactt ccgctttcat catatttcta ctgatgaggt     1680

gtatggtgac ttaccccatc cggatgaagt aaatagcaat gaaacgttgc cgctatttac     1740

ggaaatgaca gcatacgcgc caagtagtcc atattctgct tctaaagctt ccagcgatca     1800

tttggttcgc gcatggaaac gtacttatgg tttaccgacc attgtgacta attgctcgaa     1860

caactatggt ccttatcatt tcccggaaaa gcttattcca ctggttattc ttaatgcact     1920

ggaaggtaag gcattaccta tttatggcaa aggagatcag atccgcgact ggttgtatgt     1980

agaggatcat gctcgagcgt tatataccgt cgtaaccgaa ggtaaagcgg gcgaaactta     2040

taacattggt ggacacaacg aaaagaaaaa catcgacgta gtgttcacta tttgtgattt     2100

gttggatgag atagtcccga aagagaaatc ttatcgtgag caaattacct atgttgctga     2160

tcgcccaggg catgatcgcc gttatgcaat tgatgccgat aaaattagcc gcgaattggg     2220

ctggaaacca caggaaacgt ttgagagcgg gattcgtaaa actgtggaat ggtatctgtc     2280

caatacaaaa tgggttgata atgtgaaaag tggtgcctat caatcgtgga ttgaacagaa     2340

ctatgggggc cgccactaat gaatatcctc ctttttggca aaacagggca ggttggttgg     2400

gaactacagc gtgctctggc acctctgggt aatttgattg ctcttgatgt tcactccact     2460

gattactgtg gtgattttag taaccctgaa ggtgtggctg aaaccgttag aagcattcgg     2520

cctgatatta ttgtcaacgc agccgctcac accgcagtag acaaagcaga atcagaaccg     2580

gagtttgcac aattactgaa cgcgacgagt gtcgaagcga tcgcgaaagc agccaatgaa     2640

gtcggcgctt gggttattca ctactctact gactacgtat ttccggggac cggtgaaata     2700

ccatggcagg aggaggatgc aaccgcaccg ctaaatgttt acggtgaaac caagttagca     2760

ggagaaaaag cattacaaga gcattgtgcg aagcacctta ttttccggac cagctgggtc     2820

tatgcaggta aaggaaataa cttcgccaaa acgatgttgc gtctggcaaa agagcgtgaa     2880

gaattagccg ttattaatga tcagtttggt gcgccaactg gcgcagagtt gctggctgat     2940

tgtacggcac atgccattcg tgtggcactg aataaaccgg aagtcgcagg tttgtaccat     3000

ctggtagcca gtggtaccac aacctggcac gattatgctg cgctggtttt tgaagaggcg     3060

cgcaaagcag gcattcccct tgcactcaac aagctcaacg cagtaccaac aacagtctat     3120

cctacaccag ctcgtcgtcc acataactct cgccttaata cagaaaaatt tcagcagaac     3180

tttgcgcttg tcttgcctga ctggcaggtt ggtgtgaaac gcatgctcaa cgaattattt     3240

acgactacag caatttaata gtttttgcat cttgttcgtg atggtggaac aagatgaatt     3300

aaaaggaatg atggaatgaa tacgcgtaaa ggtattattt tagcgggtgg ttctggtaca     3360

cgtctttatc ctgtgactat ggctgtcagt aaacagctgt taccgattta tgataaaccg     3420

atgatctatt acccgctctc tacactgatg ttggcgggta ttcgcgatat tttgattatc     3480

agcacgccac aggatactcc tcgttttcaa caactgctgg gtgatgggag ccagtggggg     3540

ctaaatcttc actacaaagt gcaaccgagt ccggatggtc ttgcgcaggc atttatcatc     3600

ggtgaagagt ttatcggtgg tgatgattgt gctttggtac ttggtgataa tatcttctac     3660

ggtcacgacc tgcctaagtt aatggatgcc gctgttaaca aagaaagtgg tgcaacggta     3720

tttgcctatc acgttaatga tcctgaacgc tatggtgtcg ttgagtttga taaaaacggt     3780

actgcaatca gcctggaaga aaaaccgtta caaccaaaaa gtaattatgc ggtaaccggg     3840

ctttatttct atgataacta cgttgtggaa atggcgaaaa atcttaagcc ttctgcccgc     3900

ggtgaactgg aaattaccga tattaaccgt atctatatgg aacaggggca tttatctgtt     3960

gccatgatgg gacgtggata tgcctggctg gacacgggga cacatcaaag tcttattgaa     4020

gcaagcaact tcattgccac cattgaagag cgccagggct tgaaagtttc ctgcccggaa     4080

gaaattgctt accgtaaagg gtttattgat gctgagcagg tgaaagtatt agctaaaccg     4140

ctgaaaaaaa atgcttatgg tcagtatctg ctaaaaatga ttaaaggtta ttaataaaat     4200

gaatgttatt aaaacagaaa ttccagatgt actgattttt gaaccgaaag tttttggtga     4260

tgagcgtggt ttctttatgg aaagctttaa tcagaaagtt ttcgaagagg ctgtagggcg     4320

gaaggttgaa tttgttcagg ataatcattc taaatcgtgt aaaggtgtac ttagaggttt     4380

acactttcag cttcctccct ttgagcaggc aaaattagta aggtgtatag ttggcgaggt     4440

atttgatgtt gcagtagaca ttagacctaa ttctgaaaca tttggttcat gggttggagt     4500

aactctttcg tcagaaaata aaaggcagct atggattcca gaaggattcg cccatggttt     4560

tttaacttta agtgatattg cagagtttgt ttataaaact aacaactatt attctttaaa     4620

tcatgaaagg ggagtcattt ggaacgatga ggaaattaac attgcctggc cctctcaatc     4680

agagaagatt ctgtcacaga aagatattaa tttaccatca tttagatttg ttcaaatgtt     4740

tagcaagtag tgttatcttt acactgcaca tagtcatcat tttttatgct ttaagtaaat     4800

tatattgcac atctataaca caaagcgcaa taatatttcg acctgatgaa ggtttgtggt     4860

tatttatctt tctaggcgtt ttttatgact aaaatagttg tggtttctac agctccaata     4920

ttcccgacaa ataatgggta caaaagttct gtattaggaa gaattgatga gttattaaat     4980

gaggataatg aggtcgtttt gattgaaata aaccttgaaa atgttacgga aaagaaagat     5040

gaattaatac caacaagatt taataatatt caaagatatg aagtaaaaaa aatatctaga     5100

tcatttattg ccgagttaca aatattattt gatatcagaa ctcggtatga acaattattt     5160

tcttctgctg acattagaga taacataaaa aagataattg atttagaaaa accttctatt     5220

attattgctg agtctatatg ggcgttgcaa gcattgccta ttgaaattag tgcgagaata     5280

cactgtgtta ttcatgatgt ggcaactgat ttctttaaag aaatgtttgt atctcataat     5340

gaggttgtac gaaaaatttt gttttttaat gattacctaa agttgaaaat tactgaagaa     5400

aatattatca aacgtttgag agttgagcaa tttatctttc tgacagaaga agataaatgt     5460

tggtataaaa caagatacaa tattgatgag ggttgttgtt ccttagcgag caatcatctt     5520

tatgtagaaa agattaagag aactatcaat ttccaaaccc ctttcctgct tattcccggt     5580

agcattgaat tttcacaaaa tttttacggc ttaaattggt ttataaaaaa tatatatcct     5640

ggattaaata ggaaaataag aatagttgta acaggaaagg catcagataa aaaaataaag     5700

atgttaaact gtggagagga aattaccttt acgggagagc ttgacttttc cacatataat     5760

aaacttagct caacatgctt gtgtgttatt gcaccgatta caacgggcac tggaattaaa     5820

ataaaaatat tagaagctgt acaaaaaggt attcctgtac ttacaacaaa atttgcttca     5880

aaaggaatat gttccgattt atgtttttat tgcgaggagg atactgacac aaactttgtc     5940

aatttaatta acagttttct tgaaacgaca ttaagagtcc aagaatgaat ttattgcttt     6000

tttcagtcct tgcgtttggt ttaatattgg ctttggccca taataataaa agtggagata     6060

ttaacgcata cttaatgttt tttctcgtgg tcctaatggt attaatatca gggctgcgta     6120

tgaatgatag tgattatatc gaatacagga aaatgtataa tgaagtgcct attttatgtg     6180

actttagtct cgcatctata agagatatac atggggaggt aggctatcta ttcttatcat     6240

caatctttaa aactttatgc ttgccatttc aattatttct tttttttatt gcttttttat     6300

cactcctgct tacatatttt tcattcagaa aaataagttt aataccgata ctatcgttag     6360

ttttttattt aagccatgct tttatagtta gagatttgat tcaaattagg gcaggattag     6420

ctgttagcat atcattatat tcaataatta aatttaaagg aaataaaagt ataattacag     6480

gagttttatt tgcttctttg attcattctg gggcgcttat tattgctctt tgttatcctt     6540

ttttcaaaaa aaaatacata acattaaaaa tgatgttgtt tttattttta gtgtcaatta     6600

ttttttctta tttgaatggg cttaatttat cgatacaact cttatctcaa tatagtttgc     6660

ttccaactgc aatttcgaat tatgttggtt gggaagaata tgattatcgg gtgagtatat     6720

ttactaatcc ggtttttatt aaaggtgttt ttttaattgt cttaatgcac aaatatgtac     6780

tttcagatat taaaaatgag aaaattatag tgctttataa cttatatgtt ttaggtgtat     6840

tagctatggt tgcattgagt gggatggcta ttctttcagg ccgtctttca tcctttctga     6900

cactaggtga aagcatttta attgtatatg ctctgttcta caaaagaaat acacctctgg     6960

cgtttctaat tttttctttt ttaacaattg tgcaattagg atatgatcta tttatttcta     7020

atgtgcatcc tgagcttact ctgattatat ttgggtgaat ctaagtgaaa aataataaaa     7080

taggcatact tatctctaaa atacaaaatc ttggacctgt gaatgtagta cgaggattga     7140

taaaagaaaa taaaaaatat gcttttactg ttttttgttt aacaaatagc gtagataaaa     7200

atatatatga tgagttatgc tgtttaggag ccaaggttat attaatacca gatggtactt     7260

ggttcagcaa aattttattt gtgagaagtt ttttaaagga acatccacat aatatcttac     7320

attcacatgg gatcacggcc gatatgtttt cttactttct gaatggcgtg aaaatatcta     7380

ctattcacaa tagactagat gaggattata tcccattatt tggcgcggtt aaagggaatg     7440

ctatatatta tcttcatcgt tttatattac gaagatttaa tcatatcgtt gcttgctcag     7500

cagcggtcca atcaaaactg aaacaatcga aagtaaaaac taaaataacc accatccaga     7560

atgggattga tataactagg tttaagacac ttgagtctga taaaaaaaaa ttattgaggg     7620

aaaaacacgg atttgatagt gaaaaaagaa tatttatata ttgtggctcg ttatcattaa     7680

ggaaaaatat tgcttacctc ttggaacact tagccatcga agaaaatgat atatttttaa     7740

ttctaggtga tggtgaactt tttagatatt gtaaggataa atattctaaa gatttacggt     7800

atatatttat ggggaaagtt gaatgccctc ttgaatatta tcaattatca gatatttttg     7860

tttccgcttc tttatcggaa gggctcccct tggcactatt agaagctgcc tctactgggt     7920

gctatttata tgttagcgat atagagcccc atagagaaat tgcatctcta ttaggagagg     7980

aaaatatttc tatgtttaaa attaaggatg gatcatataa ttatttgcaa cctaaaataa     8040

aaaaagctga ctataacgct ctttctgacg ataaacttta caatatatcc gataaaaaaa     8100

tgtcaaatct ttatgacaaa ctttttgttt ctttattaga gcagaggcac taatataatg     8160

atttatgttt cggtaatttc tcatggtcat ttcaaaactc ttaaggaatt aggagcagta     8220

tcaaaattaa ataatcacag cagaattaaa gttatcatca aagataattt aggagagagc     8280

gagcttttgg atttttgtca ggaaaacaaa ataacttatt taaggtctaa agagaaaaaa     8340

ggatttggag agaataataa tgaagttttt tcctctatat cctccttaat tactaaggaa     8400

gatttttttg tggttatgaa tcctgatata tatattgagt gctctgatct attagatgtc     8460

gtagatgagt gtggttcagc gaatgttaat ctagcaacga taaatttata cagggatttt     8520

gataaaaaaa catatgataa ctcagtaagg aaatttccct cggcaattga tttttttatg     8580

tcatttttat ttaagaaaaa tgactgtgta gtaaataaga acaaaataac gaaaccaaca     8640

tatgttgatt gggctgcagg ttcttttcta atatttaatg ccttctttta ttcaaaactc     8700

aacggattca acgaaaagta ttttatgtat tgcgaagata ttgatatatg ttggcgagct     8760

aaaaaacact tcaatacttc agttttatac tatccatgct atgcagcaat tcatttggca     8820

caatttaaca atcgtaggat ttttagtaga catttcattt ggcatataaa aagtattatc     8880

ctttttttat tatataaaaa tggtatgctg cgttctagta agttgcttta atgctaatat     8940

tcttttaaga ggtgagaatg atacctgtta ttttggctgg tggttcggga agtcgcttgt     9000

ggccactttc acgagaaaag ttccccaagc agtttttaaa gttgactggc agtttgacaa     9060

tgttgcagtc aacattgtca cgtcttaata atttaaatgc tgatgattca atagttatat     9120

gcaacgaaga gcatagattt attgttgcag aacaattaag agagttaggc aaactttcaa     9180

ataacattat tcttgaaccc aaaggtcgta atacagcccc tgctataaca ctcgcagcat     9240

tagcagcaaa aagaaaattc gctgatgaag atccattgat tcttatttta gctgcagatc     9300

acaacatcca agacgaacat gttttctgtg aggcaattaa taaggcgtca tctttagcta     9360

gttatggaaa actagtgact tttggtatcg ttccattcaa acctgaaact gggtatggct     9420

atattcgtcg cggtgatgaa gtgcctgtag atgagcagca tgcggtggcc tttgaagtgg     9480

cgcagtttgt cgaaaaaccg aatctggaaa ccgcgcaggc ctatgtggca agcggcgaat     9540

attactggaa cagcggtatg ttcctgttcc gtgccggacg ctatctcgaa gaactgaaaa     9600

agtatcgtcc ggatattctc gatgcctgtg aaaaagcgat gagcgccgtc gatccggatc     9660

tcgattttat tcgtgtggat gaagaggcgt ttctcgcttg tccggaagag tcggtggatt     9720

acgcggtcat ggaatgcacg gcagatgccg ttgtggtgcc gatggatgcg ggctggagcg     9780

atgtcggttc ctggtcttca ttatgggaga tcagcgccca caccgccgag ggcaacgttt     9840

gccacggcga tgtgattaat cacaaaactg aaaacagcta tgtgtacgcc gaatctggcc     9900

tggtcaccac cgtcggggtg aaagatttgg tggtagtgca gaccaaagat gcagtgctga     9960

ttgccgaccg taatgcggtg caggatgtga agaaagtggt cgagcagatc aaagctgatg    10020

gtcgccatga gcatcgggtg catcgcgaag tgtatcgtcc gtggggcaaa tatgactcta    10080

tcgacgcggg cgaccgctac caggtgaaac gcatcaccgt gaaaccgggc gaaggtttgt    10140

cggtacagat gcattatcat cgcgcggaac actgggtggt tgtcgcggga acggcaaaag    10200

tcactatcaa cggtgatatc aaactgcttg gtgaaaacga gtccatttat attccgctgg    10260

gggcgatgca ctgcctggaa aacccgggga aaatagattt agaattaatt gaagttcgct    10320

ctggtgcata tcttgaagaa gatgatgtta ttagatgtta tgatcgctat ggacgaaagt    10380

aatatataat aattatttca gaattagaaa tgataattat aagttttcgt ctggataaac    10440

aatagatagt atgggttgga aaatatgagt tctttaactt gttttaaagc ttacgacatt    10500

cgcgggaaat taggtgaaga actgaatgaa gatatcgcct ggcgcattgg tcgcgcctat    10560

ggcgaatttc tcaaaccgaa aaccattgtg ttaggcggtg atgtccgtct caccagcgaa    10620

accttaaaac tggcgctggc aaaaggttta caggatgcgg gcgtcgatgt gctggatatt    10680

ggcatgtccg gcaccgaaga gatttatttc gccacgttcc atctcggcgt ggatggcggc    10740

attgaagtta ccgccagcca taatccgatg gattacaacg gcatgaagct ggtgcgcgaa    10800

ggggctcgcc cgatcagcgg tgataccgga ctgcgcgacg tccagcgtct ggcagaagct    10860

aacgactttc ctcccgtcga tgaaaccaaa cgcggtcgct atcagcaaat caatctgcgt    10920

gacgcttacg ttgatcacct gttcggttat atcaatgtca aaaaccttac gccgctcaag    10980

ctggtgatca actccgggaa tggcgcagcg ggtccggtgg tggacgctat cgaagcccgc    11040

tttaaagccc tcggcgcacc ggtggagtta atcaaagtgc ataacacgcc ggacggcaat    11100

ttccccaacg gtattcctaa cccgttgctg ccggaatgtc gcgacgacac ccgcaatgcg    11160

gtcatcaaac acggcgcgga tatgggcatt gcctttgatg gcgattttga ccgctgtttc    11220

ctgtttgacg aaaaagggca gtttattgag ggctactaca ttgtcggcct gctggcagaa    11280

gcgttcctcg aaaaaaatcc cggcgcgaag atcatccacg atccacgtct ctcctggaac    11340

accattgatg tggtgacggc cgcgggcggc acgccggtga tgtcgaaaac aggacacgcc    11400

tttattaaag aacgtatgcg caaggaagac gccatctacg gtggcgaaat gagcgctcac    11460

cattacttcc gcgatttcgc ttactgtgac agcggcatga tcccgtggct gctggtcgcc    11520

gaactggtgt gcctgaaagg aaaaacgctg ggcgaactgg tgcgcgaccg gatggcggcg    11580

tttccggcaa gcggtgagat caacagaaaa ctggcgcacc ctgttgaggc gattaaccgc    11640

gtggaacagc attttagccg tgaggtgctg gcggtggatc gcaccgatgg catcagcatg    11700

acctttgccg actggcgctt taacctgcgc tcttccaaca ccgaaccggt ggtgcgcctg    11760

aatgtggaat ctcgcggtga tgttcaggtt atggtaatcc atactcaaga aatattatca    11820

attttgacgt cataaagaat aagccctgac aagttagggc ttaattaata tatatttttt    11880

ttgaattggg gatttgtggt aagattttta atatgttatt taatgtggtt gaattaatgt    11940

tgactggaaa ataataatga gaacgaaaaa agcattacac aactttaaag ttgatttatt    12000

aattactttt ttattggttt tgctagggtt ttatattcga actgtttttg tttcaaaaat    12060

gggaagtgat attactggag tgatgttact attcacacag ttgacagcat atctcaattt    12120

ggcagaatta ggtattggaa ttgcagctgc cagcgtatta tataaaccgc tcagcgagaa    12180

tgaatacaat aaaataactt acataatatc tttgctctca gtcatataca aatatatatt    12240

tgtgtttgtt ttgattcttg gcgttgttat aggtatctgt atttattact ttattgattc    12300

tgtaaaggtt gtaaatggcg tttttttata ttgggctttg ttcgttttta atacatcgtt    12360

gacatatagt tatgctaaat actccacatt attaactgct aatcagcggt actcagcagt    12420

aagaaaaatt caaggtggcg gaaaagttat aataattgta tttcagatat taattttgtg    12480

ctttacgcaa agtttcatac tttatttgtt agttgagact ttaggtattt tttctcaata    12540

tttgattttt aaaaaaataa ttgggaacgg aaatcaatat ctcagtaatg aggttttact    12600

tattgaaagc gataaacttt tgataaaaaa agaattaaaa ataagaataa aaaatatgtt    12660

cttccataaa ataggtgctg tgcttgtcct taatacagac tacctgcttg tatcaaagtt    12720

tctgacatta agttatgtga caatttttgg cagctatatg atggtatttc agatagtaac    12780

tgttttgatg tcaagttttg ttaatgctat tactgcagga atgggtaatt acttaattaa    12840

taaaagtaat ttagaaatta aggaaattac acgtcaattt tatgtgatat ttatcgcctt    12900

tgcaacattc atatcactaa atatgttttt tcttgttaat gattttatcg caaaatggat    12960

aggtgttaat tatacattaa gtaacaccct agttgcatta atgattgtta acgtattcat    13020

tagtgttgtc agggtacctt ctgatatatt aaaaaacgca agtggacatt ttggtgatat    13080

ttattatcca ttattagaag gtgtgctgaa tattacgata tccatcattt tggctatcat    13140

tattggatta cctggcatta ttatagggac aatagtatct aacttaatag taataatgct    13200

tgcgaaacca ttatatcttt actctaagtt atttaatctt agaaatccga cgagggttta    13260

ttttgaattt atttctcggc ctatgttata ttcattatgt gtgattgggg tgagctattt    13320

attgcgcgat gaaatatatt catttaaagt aagtacatgg ttggatttta ttaacaagct    13380

actcttagtc tctactccta gcatattggt aatatgtgct attttctcta cggatagtga    13440

ctttagatta tttttcagaa aaattatata tgtgattatg aagaaataaa aatttcgaaa    13500

atgtattaat cgaaattatg caacgagctt tatttttata aatgatatgt gatcttttcg    13560

cgaataggag taaggatccg tgtaggctgg agctgcttcg aagttcctat actttctaga    13620

gaataggaac ttcggaatag gaactaagga ggatattcat atggataaag ccgtaagcat    13680

ataagcatgg ataagctatt tatactttaa taagtacttt gtatacttat ttgcgaacat    13740

tccaggccgc gagcattcag cgcggtgatc acacctgaca ggagtatgta atgtccaagc    13800

aacagatcgg cgtagtcggt atggcagtga tgggacgcaa ccttgcgctc aacatcgaaa    13860

gccgtggtta taccgtctct attttcaacc gttcccgtga gaagacggaa gaagtgattg    13920

ccgaaaatcc aggcaagaaa ctggttcctt actatacggt gaaagagttt gtcgaatctc    13980

tggaaacgcc tcgtcgcatc ctgttaatgg tgaaagcagg tgcaggcacg gatgctgcta    14040

ttgattccct caaaccatat ctcgataaag gagacatcat cattgatggt ggtaacacct    14100

tcttccagga cactattcgt cgtaatcgtg agctttcagc agagggcttt aacttcatcg    14160

gtaccggtgt ttctggcggt gaagaggggg cgctgaaagg tccttctatt atgcctggtg    14220

gccagaaaga agcctatgaa ttggtagcac cgatcctgac caaaatcgcc gccgtagctg    14280

aagacggtga accatgcgtt acctatattg gtgccgatgg cgcaggtcac tatgtgaaga    14340

tggttcacaa cggtattgaa tacggcgata tgcagctgat tgctgaagcc tattctctgc    14400

ttaaaggtgg cctgaacctc accaacgaag aactggcgca gacctttacc gagtggaata    14460

acggtgaact gagcagttac ctgatcgaca tcaccaaaga tatcttcacc aaaaaagatg    14520

aagacggtaa ctacctggtt gatgtgatcc tggatgaagc ggctaacaaa ggtaccggta    14580

aatggaccag ccagagcgcg ctggatctcg gcgaaccgct gtcgctgatt accgagtctg    14640

tgtttgcacg ttatatctct tctctgaaag atcagcgtgt tgccgcatct aaagttctct    14700

ctggtccgca agcacagcca gcaggcgaca aggctgagtt catcgaaaaa gttcgtcgtg    14760

cgctgtatct gggcaaaatc gtttcttacg cccagggctt ctctcagctg cgtgctgcgt    14820

ctgaagagta caactgggat ctgaactacg gcgaaatcgc gaagattttc cgtgctggct    14880

gcatcatccg tgcgcagttc ctgcagaaaa tcaccgatgc ttatgccgaa aatccacaga    14940

tcgctaacct gttgctggct ccgtacttca agcaaattgc cgatgactac cagcaggcgc    15000

tgcgtgatgt cgttgcttat gcagtacaga acggtattcc ggttccgacc ttctccgcag    15060

cggttgccta ttacgacagc taccgtgctg ctgttctgcc tgcgaacctg atccaggcac    15120

agcgtgacta ttttggtgcg catacttata agcgtattga taaagaaggt gtgttccata    15180

ccgaatggct ggattaa                                                   15197


