
                                SEQUENCE LISTING

<110> Thor Wagner
      Jaya Sahini

<120> METHODS AND COMPOSITIONS FOR ENGINEERING
  CD4-DEFICIENT CAR T CELLS AND ANTI-CD4 CAR T CELLS
  

<130> SCRI.206WO

<150> 62820387            
<151> 2019-03-19  

<160> 9

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD4-G1 (antisense)

<400> 1
agggactccc cggttcattg                                             20

<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD4-G2 (antisense)

<400> 2
gttcattgtg gccttgccga                                             20

<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD4-G3 (sense)

<400> 3
ggcaaggcca caatgaaccg                                             20

<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD4-G4 (antisense)

<400> 4
gcgcgatcat tcagcttgga                                             20

<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD4-G5 (antisense)

<400> 5
gtcagcgcga tcattcagct                                             20

<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD4-G6 (sense)

<400> 6
gaggtgcaat tgctagtgtt                                             20

<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD4-G7 (antisense)

<400> 7
cattcagctt ggatggacct                                             20

<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD4-G8 (antisense)

<400> 8
tcattcagct tggatggacc                                             20

<210> 9
<211> 249
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv for anti-CD4 chimeric antigen receptor

<400> 9
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
            20                  25                  30          
Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
        115                 120                 125             
Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser
    130                 135                 140                 
Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val
145                 150                 155                 160 
Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Asp Trp Ile Gly
                165                 170                 175     
Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe Lys
            180                 185                 190         
Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met
        195                 200                 205             
Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala
    210                 215                 220                 
Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr Trp Gly
225                 230                 235                 240 
Gln Gly Thr Thr Val Thr Val Ser Ser
                245                 

