                         SEQUENCE LISTING

<110>  H. Lee Moffitt Cancer Center and Research Institute, Inc.
 
<120>  CHIMERIC ANTIGEN RECEPTORS WITH ENHANCED TUMOR INFILTRATION

<130>  320803-2340

<150>  US 62/820,797
<151>  2019-03-19

<150>  US 62/820,798
<151>  2019-03-19

<150>  US 62/820,800
<151>  2019-03-19

<150>  US 62/914,685
<151>  2019-10-14

<150>  US 62/914,718
<151>  2019-10-14

<150>  US 62/914,724
<151>  2019-10-14

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp Leu 
1               5                   10                  15      


Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val Phe 
            20                  25                  30          


Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly Asn 
        35                  40                  45              


Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser Val 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe Val 
65                  70                  75                  80  


Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly Leu 
                85                  90                  95      


His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly Phe 
            100                 105                 110         


Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln His 
    130                 135                 140                 


Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val Ala 
145                 150                 155                 160 


Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu Gly 
                165                 170                 175     


Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn Val 
            180                 185                 190         


Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser Tyr 
        195                 200                 205             


Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His Lys 
    210                 215                 220                 


Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe Phe 
225                 230                 235                 240 


Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu Lys 
                245                 250                 255     


Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg Leu 
            260                 265                 270         


Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu Asn 
        275                 280                 285             


Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu Tyr 
    290                 295                 300                 


His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val His 
305                 310                 315                 320 


Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser Val 
                325                 330                 335     


Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu Leu 
            340                 345                 350         


Leu Leu 
        


<210>  2
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2
atggatcagt tccccgagag cgtgaccgag aacttcgagt acgatgatct ggccgaggcc       60

tgctacatcg gcgacatcgt ggtgttcggc accgtgtttc tgagcatctt ctacagcgtg      120

atcttcgcca tcggcctcgt gggcaatctg ctggtggtgt ttgccctgac caacagcaag      180

aaacccaagt ccgtgaccga catctacctg ctgaatctgg ccctgagcga cctgctgttc      240

gtggccacac tgcctttctg gacccactac ctgatcaacg agaagggcct gcacaacgcc      300

atgtgcaagt tcaccaccgc ctttttcttc atcggctttt tcggctccat cttcttcatc      360

accgtgatca gcatcgaccg ctacctggcc attgtgctgg ccgccaacag catgaacaac      420

cggacagttc agcacggcgt gaccatcagc cttggagttt gggccgctgc cattctggtt      480

gccgctcctc agttcatgtt caccaagcag aaagaaaacg agtgcctggg cgactacccc      540

gaggtgctgc aagaaatttg gcccgtgctg cggaacgtgg aaacaaactt cctgggcttc      600

ctgctgcctc tgctgatcat gagctactgc tacttccgga tcatccagac actgttcagc      660

tgcaaaaacc acaagaaggc caaggccatc aagctgatcc tgctggtcgt gatcgtgttc      720

ttcctgttct ggacacccta caacgtgatg atcttcctgg aaaccctgaa gctgtacgac      780

ttcttcccct cctgcgacat gcggaaggat ctgagactgg ccctgtccgt gacagagaca      840

gtggccttca gccactgctg cctgaatcct ctgatctacg cctttgccgg cgagaagttc      900

agaagatacc tgtaccacct gtacggcaag tgcctggctg tgctgtgtgg cagatccgtg      960

cacgtggact ttagcagcag cgagagccag agaagcagac acggctctgt gctgagcagc     1020

aacttcacct accacacctc tgatggcgac gccctgctgc ttctg                     1065


<210>  3
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser Glu 
    130                 135         


<210>  4
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
tgtaccggat gcagctgctg agctgtatcg ccctgtctct ggccctggtc acaaactctg       60

gcgccaactg ggtcaacgtg atcagcgacc tgaagaagat cgaggacctg atccagagca      120

tgcacatcga cgccacactg tacaccgaga gcgacgtgca ccctagctgt aaagtgaccg      180

ccatgaagtg ctttctgctg gaactgcaag tgatcagcct ggaaagcggc gacgccagca      240

tccacgacac cgtggaaaac ctgatcatcc tggccaacaa cagcctgagc agcaacggca      300

atgtgaccga gtccggctgc aaagagtgcg aggaactgga agagaagaat atcaaagagt      360

tcctgcagag cttcgtgcac atcgtgcaga tgttcatcaa caccagcg                   408


<210>  5
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile Ser 
1               5                   10                  15      


Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
            20                  25                  30          


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
        35                  40                  45              


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
    50                  55                  60                  


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
65                  70                  75                  80  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
                85                  90                  95      


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
            100                 105                 110         


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
        115                 120                 125             


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
    130                 135                 140                 


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
145                 150                 155                 160 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
                165                 170                 175     


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
            180                 185                 190         


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
        195                 200                 205             


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
    210                 215                 220                 


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
225                 230                 235                 240 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
                245                 250                 255     


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
            260                 265                 270         


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
        275                 280                 285             


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
    290                 295                 300                 


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
305                 310                 315                 320 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
                325                 330                 335     


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Pro 
            340                 345                 350         


<210>  6
<211>  1057
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tcgcaaagtg       60

tgtaacggaa taggtattgg tgaatttaaa gactcactct ccataaatgc tacgaatatt      120

aaacacttca aaaactgcac ctccatcagt ggcgatctcc acatcctgcc ggtggcattt      180

aggggtgact ccttcacaca tactcctcct ctggatccac aggaactgga tattctgaaa      240

accgtaaagg aaatcacagg gtttttgctg attcaggctt ggcctgaaaa caggacggac      300

ctccatgcct ttgagaacct agaaatcata cgcggcagga ccaagcaaca tggtcagttt      360

tctcttgcag tcgtcagcct gaacataaca tccttgggat tacgctccct caaggagata      420

agtgatggag atgtgataat ttcaggaaac aaaaatttgt gctatgcaaa tacaataaac      480

tggaaaaaac tgtttgggac ctccggtcag aaaaccaaaa ttataagcaa cagaggtgaa      540

aacagctgca aggccacagg ccaggtctgc catgccttgt gctcccccga gggctgctgg      600

ggcccggagc ccagggactg cgtctcttgc cggaatgtca gccgaggcag ggaatgcgtg      660

gacaagtgca accttctgga gggtgagcca agggagtttg tggagaactc tgagtgcata      720

cagtgccacc cagagtgcct gcctcaggcc atgaacatca cctgcacagg acggggacca      780

gacaactgta tccagtgtgc ccactacatt gacggccccc actgcgtcaa gacctgcccg      840

gcaggagtca tgggagaaaa caacaccctg gtctggaagt acgcagacgc cggccatgtg      900

tgccacctgt gccatccaaa ctgcacctac ggatgcactg ggccaggtct tgaaggctgt      960

ccaacgaatg ggcctaagat cccgtccatc gccactggga tggtgggggc cctcctcttg     1020

ctgctggtgg tggccctggg gatcggcctc ttcatgc                              1057


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Tyr Phe Asp Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Asn Met Asp Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ser 
        115         


<210>  8
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
caggttcagc tggttcagtc tggcggagga ctggttcaac caggcggaag cctgagactg       60

tcttgtgccg ccagctactt cgacttcgac agctacgaga tgagctgggt ccgacaggcc      120

cctggcaaag gacttgagtg gatcggcagc atctaccaca gcggcagcac ctactacaac      180

cccagcctga agtccagagt gaccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaata ccctgagagc cgaggacacc gccacctact attgcgccag agtgaacatg      300

gaccgcttcg actattgggg ccagggcaca ctggtcaccg tgtctagttc t               351


<210>  9
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly 
1               5                   10                  15      


Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe 
            20                  25                  30          


Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser 
        35                  40                  45              


Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu 
    50                  55                  60                  


Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro 
65                  70                  75                  80  


Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn 
                85                  90                  95      


Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala 
            100                 105                 110         


Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr 
        115                 120                 125             


Ile Cys Met Gln Arg Thr Val 
    130                 135 


<210>  10
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser 
1               5                   10                  15      


Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys 
            20                  25                  30          


Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser 
        35                  40                  45              


Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp 
    50                  55                  60                  


Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val 
65                  70                  75                  80  


His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu 
                85                  90                  95      


Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala 
            100                 105                 110         


Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro 
        115                 120                 125             


Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135             


<210>  11
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val 
    130             


<210>  12
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp 
1               5                   10                  15      


Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn 
            20                  25                  30          


Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu 
        35                  40                  45              


Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser 
    50                  55                  60                  


Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln 
65                  70                  75                  80  


Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu 
                85                  90                  95      


Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr 
            100                 105                 110         


Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr 
        115                 120                 125             


Val 
    


<210>  13
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
1               5                   10                  15      


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
            20                  25                  30          


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
        35                  40                  45              


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
    50                  55                  60                  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
65                  70                  75                  80  


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
                85                  90                  95      


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
            100                 105                 110         


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
        115                 120             


<210>  14
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Ser Lys Cys His Asn Tyr Asp Leu Lys Pro Ala Lys Trp Asp Thr 
1               5                   10                  15      


Ser Gln Glu Gln Gln Lys Gln Arg Leu Ala Leu Thr Thr Ser Gln Pro 
            20                  25                  30          


Gly Glu Asn Gly Ile Ile Arg Gly Arg Tyr Pro Ile Glu Lys Leu Lys 
        35                  40                  45              


Ile Ser Pro Met Phe Val Val Arg Val Leu Ala Ile Ala Leu Ala Ile 
    50                  55                  60                  


Arg Phe Thr Leu Asn Thr Leu Met Trp Leu Ala Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu 
                85                  90                  95      


Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn 
            100                 105                 110         


Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala 
        115                 120                 125             


Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu 
    130                 135                 140                 


Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
145                 150                 155                 160 


Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser 
                165                 170                 175     


Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys 
            180                 185                 190         


Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn 
        195                 200                 205             


Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val 
    210                 215                 


<210>  15
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Asn Lys Glu Val Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn 
            20                  25                  30          


Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn 
        35                  40                  45              


Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu 
                85                  90                  95      


Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser 
            100                 105                 110         


Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Lys Arg Ala Val 
    130             


<210>  16
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp 
1               5                   10                  15      


Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr 
            20                  25                  30          


Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu 
        35                  40                  45              


Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys Leu Val Lys Ser 
    50                  55                  60                  


Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala Asn Gly Ser Trp Gln 
65                  70                  75                  80  


Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu 
                85                  90                  95      


Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr 
            100                 105                 110         


Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala 
        115                 120                 125             


Val 
    


<210>  17
<211>  1262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Tyr Phe 
        35                  40                  45              


Asp Phe Asp Ser Tyr Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Val Asn Met Asp Arg Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Thr Thr Thr Pro Ala Pro 
    130                 135                 140                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
145                 150                 155                 160 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                165                 170                 175     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            180                 185                 190         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        195                 200                 205             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    210                 215                 220                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
225                 230                 235                 240 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                245                 250                 255     


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            260                 265                 270         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        275                 280                 285             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    290                 295                 300                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
305                 310                 315                 320 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                325                 330                 335     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            340                 345                 350         


Leu His Met Gln Ala Leu Pro Pro Arg Pro Gly Glu Gly Arg Gly Ser 
        355                 360                 365             


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Trp Leu 
    370                 375                 380                 


Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile Ser Arg Lys 
385                 390                 395                 400 


Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile 
                405                 410                 415     


Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly 
            420                 425                 430         


Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His 
        435                 440                 445             


Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys 
    450                 455                 460                 


Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr 
465                 470                 475                 480 


Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys 
                485                 490                 495     


Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser 
            500                 505                 510         


Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile 
        515                 520                 525             


Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys 
    530                 535                 540                 


Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly 
545                 550                 555                 560 


Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser 
                565                 570                 575     


Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg 
            580                 585                 590         


Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu 
        595                 600                 605             


Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His 
    610                 615                 620                 


Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly 
625                 630                 635                 640 


Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys 
                645                 650                 655     


Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val 
            660                 665                 670         


Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn 
        675                 680                 685             


Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn 
    690                 695                 700                 


Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu 
705                 710                 715                 720 


Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Pro Gly Glu 
                725                 730                 735     


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
            740                 745                 750         


Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala 
        755                 760                 765             


Leu Val Thr Asn Ser Gly Ala Asn Trp Val Asn Val Ile Ser Asp Leu 
    770                 775                 780                 


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
785                 790                 795                 800 


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
                805                 810                 815     


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
            820                 825                 830         


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
        835                 840                 845             


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
    850                 855                 860                 


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
865                 870                 875                 880 


Ile Val Gln Met Phe Ile Asn Thr Ser Glu Gly Arg Gly Ser Leu Leu 
                885                 890                 895     


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asp Gln Phe Pro 
            900                 905                 910         


Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp Leu Ala Glu Ala Cys 
        915                 920                 925             


Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val Phe Leu Ser Ile Phe 
    930                 935                 940                 


Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly Asn Leu Leu Val Val 
945                 950                 955                 960 


Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser Val Thr Asp Ile Tyr 
                965                 970                 975     


Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe Val Ala Thr Leu Pro 
            980                 985                 990         


Phe Trp Thr His Tyr Leu Ile Asn  Glu Lys Gly Leu His  Asn Ala Met 
        995                 1000                 1005             


Cys Lys  Phe Thr Thr Ala Phe  Phe Phe Ile Gly Phe  Phe Gly Ser 
    1010                 1015                 1020             


Ile Phe  Phe Ile Thr Val Ile  Ser Ile Asp Arg Tyr  Leu Ala Ile 
    1025                 1030                 1035             


Val Leu  Ala Ala Asn Ser Met  Asn Asn Arg Thr Val  Gln His Gly 
    1040                 1045                 1050             


Val Thr  Ile Ser Leu Gly Val  Trp Ala Ala Ala Ile  Leu Val Ala 
    1055                 1060                 1065             


Ala Pro  Gln Phe Met Phe Thr  Lys Gln Lys Glu Asn  Glu Cys Leu 
    1070                 1075                 1080             


Gly Asp  Tyr Pro Glu Val Leu  Gln Glu Ile Trp Pro  Val Leu Arg 
    1085                 1090                 1095             


Asn Val  Glu Thr Asn Phe Leu  Gly Phe Leu Leu Pro  Leu Leu Ile 
    1100                 1105                 1110             


Met Ser  Tyr Cys Tyr Phe Arg  Ile Ile Gln Thr Leu  Phe Ser Cys 
    1115                 1120                 1125             


Lys Asn  His Lys Lys Ala Lys  Ala Ile Lys Leu Ile  Leu Leu Val 
    1130                 1135                 1140             


Val Ile  Val Phe Phe Leu Phe  Trp Thr Pro Tyr Asn  Val Met Ile 
    1145                 1150                 1155             


Phe Leu  Glu Thr Leu Lys Leu  Tyr Asp Phe Phe Pro  Ser Cys Asp 
    1160                 1165                 1170             


Met Arg  Lys Asp Leu Arg Leu  Ala Leu Ser Val Thr  Glu Thr Val 
    1175                 1180                 1185             


Ala Phe  Ser His Cys Cys Leu  Asn Pro Leu Ile Tyr  Ala Phe Ala 
    1190                 1195                 1200             


Gly Glu  Lys Phe Arg Arg Tyr  Leu Tyr His Leu Tyr  Gly Lys Cys 
    1205                 1210                 1215             


Leu Ala  Val Leu Cys Gly Arg  Ser Val His Val Asp  Phe Ser Ser 
    1220                 1225                 1230             


Ser Glu  Ser Gln Arg Ser Arg  His Gly Ser Val Leu  Ser Ser Asn 
    1235                 1240                 1245             


Phe Thr  Tyr His Thr Ser Asp  Gly Asp Ala Leu Leu  Leu Leu 
    1250                 1255                 1260         


<210>  18
<211>  5136
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
gagtaattca tacaaaagga ctcgcccctg ccttggggaa tcccagggac cgtcgttaaa       60

ctcccactaa cgtagaaccc agagatcgct gcgttcccgc cccctcaccc gcccgctctc      120

gtcatcactg aggtggagaa gagcatgcgt gaggctccgg tgcccgtcag tgggcagagc      180

gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga accggtgcct      240

agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc      300

ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca      360

acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct      420

ttacgggtta tggcccttgc gtgccttgaa ttacttccac gcccctggct gcagtacgtg      480

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      540

ggagcccctt cgcctcgtgc ttgagttgag gcctggcttg ggcgctgggg ccgccgcgtg      600

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      660

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      720

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      780

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg      840

gggtagtctc aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc      900

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg      960

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1020

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1080

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1140

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1200

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1260

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1320

tttcaggtgt cgtgattcga attcgccacc atggccttac cagtgaccgc cttgctcctg     1380

ccgctggcct tgctgctcca cgccgccagg ccgcaggttc agctggttca gtctggcgga     1440

ggactggttc aaccaggcgg aagcctgaga ctgtcttgtg ccgccagcta cttcgacttc     1500

gacagctacg agatgagctg ggtccgacag gcccctggca aaggacttga gtggatcggc     1560

agcatctacc acagcggcag cacctactac aaccccagcc tgaagtccag agtgaccatc     1620

agccgggaca acagcaagaa caccctgtac ctgcagatga ataccctgag agccgaggac     1680

accgccacct actattgcgc cagagtgaac atggaccgct tcgactattg gggccagggc     1740

acactggtca ccgtgtctag ttctaccacg acgccagcgc cgcgaccacc aacaccggcg     1800

cccaccatcg cgtcgcagcc cctgtccctg cgcccagaag cgtgccggcc agcggcgggg     1860

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatttg ggcccctctg     1920

gctggtactt gcggggtcct gctgctttca ctcgtgatca ctctttactg taagcgcggt     1980

cggaagaagc tgctgtacat ctttaagcaa cccttcatga ggcctgtgca gactactcaa     2040

gaggaggacg gctgttcatg ccggttccca gaggaggagg aaggcggctg cgaactgcgc     2100

gtgaaattca gccgcagcgc agatgctcca gcctacaagc aggggcagaa ccagctctac     2160

aacgaactca atcttggtcg gagagaggag tacgacgtgc tggacaagcg gagaggacgg     2220

gacccagaaa tgggcgggaa gccgcgcaga aagaatcccc aagagggcct gtacaacgag     2280

ctccaaaagg ataagatggc agaagcctat agcgagattg gtatgaaagg ggaacgcaga     2340

agaggcaaag gccacgacgg actgtaccag ggactcagca ccgccaccaa ggacacctat     2400

gacgctcttc acatgcaggc cctgccgcct cggcccgggg agggcagagg cagcctgctg     2460

acatgtggcg acgtggaaga gaaccctggc cccatgtggc tgcagagcct gctgctcttg     2520

ggcactgtgg cctgcagcat ctctcgcaaa gtgtgtaacg gaataggtat tggtgaattt     2580

aaagactcac tctccataaa tgctacgaat attaaacact tcaaaaactg cacctccatc     2640

agtggcgatc tccacatcct gccggtggca tttaggggtg actccttcac acatactcct     2700

cctctggatc cacaggaact ggatattctg aaaaccgtaa aggaaatcac agggtttttg     2760

ctgattcagg cttggcctga aaacaggacg gacctccatg cctttgagaa cctagaaatc     2820

atacgcggca ggaccaagca acatggtcag ttttctcttg cagtcgtcag cctgaacata     2880

acatccttgg gattacgctc cctcaaggag ataagtgatg gagatgtgat aatttcagga     2940

aacaaaaatt tgtgctatgc aaatacaata aactggaaaa aactgtttgg gacctccggt     3000

cagaaaacca aaattataag caacagaggt gaaaacagct gcaaggccac aggccaggtc     3060

tgccatgcct tgtgctcccc cgagggctgc tggggcccgg agcccaggga ctgcgtctct     3120

tgccggaatg tcagccgagg cagggaatgc gtggacaagt gcaaccttct ggagggtgag     3180

ccaagggagt ttgtggagaa ctctgagtgc atacagtgcc acccagagtg cctgcctcag     3240

gccatgaaca tcacctgcac aggacgggga ccagacaact gtatccagtg tgcccactac     3300

attgacggcc cccactgcgt caagacctgc ccggcaggag tcatgggaga aaacaacacc     3360

ctggtctgga agtacgcaga cgccggccat gtgtgccacc tgtgccatcc aaactgcacc     3420

tacggatgca ctgggccagg tcttgaaggc tgtccaacga atgggcctaa gatcccgtcc     3480

atcgccactg ggatggtggg ggccctcctc ttgctgctgg tggtggccct ggggatcggc     3540

ctcttcatgc ccggggaggg cagaggcagc ctgctgacat gtggcgacgt ggaagagaac     3600

cctggcccca tgtaccggat gcagctgctg agctgtatcg ccctgtctct ggccctggtc     3660

acaaactctg gcgccaactg ggtcaacgtg atcagcgacc tgaagaagat cgaggacctg     3720

atccagagca tgcacatcga cgccacactg tacaccgaga gcgacgtgca ccctagctgt     3780

aaagtgaccg ccatgaagtg ctttctgctg gaactgcaag tgatcagcct ggaaagcggc     3840

gacgccagca tccacgacac cgtggaaaac ctgatcatcc tggccaacaa cagcctgagc     3900

agcaacggca atgtgaccga gtccggctgc aaagagtgcg aggaactgga agagaagaat     3960

atcaaagagt tcctgcagag cttcgtgcac atcgtgcaga tgttcatcaa caccagcgag     4020

ggcagaggca gcctgctgac atgtggcgac gtggaagaga accctggccc catggatcag     4080

ttccccgaga gcgtgaccga gaacttcgag tacgatgatc tggccgaggc ctgctacatc     4140

ggcgacatcg tggtgttcgg caccgtgttt ctgagcatct tctacagcgt gatcttcgcc     4200

atcggcctcg tgggcaatct gctggtggtg tttgccctga ccaacagcaa gaaacccaag     4260

tccgtgaccg acatctacct gctgaatctg gccctgagcg acctgctgtt cgtggccaca     4320

ctgcctttct ggacccacta cctgatcaac gagaagggcc tgcacaacgc catgtgcaag     4380

ttcaccaccg cctttttctt catcggcttt ttcggctcca tcttcttcat caccgtgatc     4440

agcatcgacc gctacctggc cattgtgctg gccgccaaca gcatgaacaa ccggacagtt     4500

cagcacggcg tgaccatcag ccttggagtt tgggccgctg ccattctggt tgccgctcct     4560

cagttcatgt tcaccaagca gaaagaaaac gagtgcctgg gcgactaccc cgaggtgctg     4620

caagaaattt ggcccgtgct gcggaacgtg gaaacaaact tcctgggctt cctgctgcct     4680

ctgctgatca tgagctactg ctacttccgg atcatccaga cactgttcag ctgcaaaaac     4740

cacaagaagg ccaaggccat caagctgatc ctgctggtcg tgatcgtgtt cttcctgttc     4800

tggacaccct acaacgtgat gatcttcctg gaaaccctga agctgtacga cttcttcccc     4860

tcctgcgaca tgcggaagga tctgagactg gccctgtccg tgacagagac agtggccttc     4920

agccactgct gcctgaatcc tctgatctac gcctttgccg gcgagaagtt cagaagatac     4980

ctgtaccacc tgtacggcaa gtgcctggct gtgctgtgtg gcagatccgt gcacgtggac     5040

tttagcagca gcgagagcca gagaagcaga cacggctctg tgctgagcag caacttcacc     5100

taccacacct ctgatggcga cgccctgctg cttctg                               5136


<210>  19
<211>  889
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Tyr Phe 
        35                  40                  45              


Asp Phe Asp Ser Tyr Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Val Asn Met Asp Arg Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Thr Thr Thr Pro Ala Pro 
    130                 135                 140                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
145                 150                 155                 160 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                165                 170                 175     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            180                 185                 190         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        195                 200                 205             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    210                 215                 220                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
225                 230                 235                 240 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                245                 250                 255     


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            260                 265                 270         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        275                 280                 285             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    290                 295                 300                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
305                 310                 315                 320 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                325                 330                 335     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            340                 345                 350         


Leu His Met Gln Ala Leu Pro Pro Arg Pro Gly Glu Gly Arg Gly Ser 
        355                 360                 365             


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Trp Leu 
    370                 375                 380                 


Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile Ser Arg Lys 
385                 390                 395                 400 


Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile 
                405                 410                 415     


Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly 
            420                 425                 430         


Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His 
        435                 440                 445             


Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys 
    450                 455                 460                 


Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr 
465                 470                 475                 480 


Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys 
                485                 490                 495     


Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser 
            500                 505                 510         


Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile 
        515                 520                 525             


Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys 
    530                 535                 540                 


Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly 
545                 550                 555                 560 


Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser 
                565                 570                 575     


Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg 
            580                 585                 590         


Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu 
        595                 600                 605             


Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His 
    610                 615                 620                 


Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly 
625                 630                 635                 640 


Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys 
                645                 650                 655     


Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val 
            660                 665                 670         


Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn 
        675                 680                 685             


Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn 
    690                 695                 700                 


Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu 
705                 710                 715                 720 


Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Pro Gly Glu 
                725                 730                 735     


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
            740                 745                 750         


Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala 
        755                 760                 765             


Leu Val Thr Asn Ser Gly Ala Asn Trp Val Asn Val Ile Ser Asp Leu 
    770                 775                 780                 


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
785                 790                 795                 800 


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
                805                 810                 815     


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
            820                 825                 830         


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
        835                 840                 845             


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
    850                 855                 860                 


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
865                 870                 875                 880 


Ile Val Gln Met Phe Ile Asn Thr Ser 
                885                 


<210>  20
<211>  1079
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Tyr Phe 
        35                  40                  45              


Asp Phe Asp Ser Tyr Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Val Asn Met Asp Arg Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Thr Thr Thr Pro Ala Pro 
    130                 135                 140                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
145                 150                 155                 160 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                165                 170                 175     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            180                 185                 190         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        195                 200                 205             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    210                 215                 220                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
225                 230                 235                 240 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                245                 250                 255     


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            260                 265                 270         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        275                 280                 285             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    290                 295                 300                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
305                 310                 315                 320 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                325                 330                 335     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            340                 345                 350         


Leu His Met Gln Ala Leu Pro Pro Arg Pro Gly Glu Gly Arg Gly Ser 
        355                 360                 365             


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Trp Leu 
    370                 375                 380                 


Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile Ser Arg Lys 
385                 390                 395                 400 


Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile 
                405                 410                 415     


Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly 
            420                 425                 430         


Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His 
        435                 440                 445             


Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys 
    450                 455                 460                 


Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr 
465                 470                 475                 480 


Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys 
                485                 490                 495     


Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser 
            500                 505                 510         


Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile 
        515                 520                 525             


Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys 
    530                 535                 540                 


Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly 
545                 550                 555                 560 


Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser 
                565                 570                 575     


Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg 
            580                 585                 590         


Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu 
        595                 600                 605             


Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His 
    610                 615                 620                 


Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly 
625                 630                 635                 640 


Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys 
                645                 650                 655     


Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val 
            660                 665                 670         


Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn 
        675                 680                 685             


Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn 
    690                 695                 700                 


Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu 
705                 710                 715                 720 


Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Pro Gly Glu 
                725                 730                 735     


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
            740                 745                 750         


Pro Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp 
        755                 760                 765             


Asp Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr 
    770                 775                 780                 


Val Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val 
785                 790                 795                 800 


Gly Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys 
                805                 810                 815     


Ser Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu 
            820                 825                 830         


Phe Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys 
        835                 840                 845             


Gly Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile 
    850                 855                 860                 


Gly Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg 
865                 870                 875                 880 


Tyr Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val 
                885                 890                 895     


Gln His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu 
            900                 905                 910         


Val Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys 
        915                 920                 925             


Leu Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg 
    930                 935                 940                 


Asn Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met 
945                 950                 955                 960 


Ser Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn 
                965                 970                 975     


His Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val 
            980                 985                 990         


Phe Phe Leu Phe Trp Thr Pro Tyr  Asn Val Met Ile Phe  Leu Glu Thr 
        995                 1000                 1005             


Leu Lys  Leu Tyr Asp Phe Phe  Pro Ser Cys Asp Met  Arg Lys Asp 
    1010                 1015                 1020             


Leu Arg  Leu Ala Leu Ser Val  Thr Glu Thr Val Ala  Phe Ser His 
    1025                 1030                 1035             


Cys Cys  Leu Asn Pro Leu Ile  Tyr Ala Phe Ala Gly  Glu Lys Phe 
    1040                 1045                 1050             


Arg Arg  Tyr Leu Tyr His Leu  Tyr Gly Lys Cys Leu  Ala Val Leu 
    1055                 1060                 1065             


Cys Gly  Arg Ser Val His Val  Asp Phe Ser Ser 
    1070                 1075                 


<210>  21
<211>  1280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
225                 230                 235                 240 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                245                 250                 255     


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            260                 265                 270         


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
        275                 280                 285             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    290                 295                 300                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
305                 310                 315                 320 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                325                 330                 335     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            340                 345                 350         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        355                 360                 365             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Pro Gly Glu Gly Arg 
    370                 375                 380                 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
385                 390                 395                 400 


Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile Ser 
                405                 410                 415     


Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
            420                 425                 430         


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
        435                 440                 445             


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
    450                 455                 460                 


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
465                 470                 475                 480 


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
                485                 490                 495     


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
            500                 505                 510         


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
        515                 520                 525             


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
    530                 535                 540                 


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
545                 550                 555                 560 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
                565                 570                 575     


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
            580                 585                 590         


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
        595                 600                 605             


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
    610                 615                 620                 


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
625                 630                 635                 640 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
                645                 650                 655     


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
            660                 665                 670         


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
        675                 680                 685             


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
    690                 695                 700                 


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
705                 710                 715                 720 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
                725                 730                 735     


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Pro 
            740                 745                 750         


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
        755                 760                 765             


Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser 
    770                 775                 780                 


Leu Ala Leu Val Thr Asn Ser Gly Ala Asn Trp Val Asn Val Ile Ser 
785                 790                 795                 800 


Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala 
                805                 810                 815     


Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala 
            820                 825                 830         


Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly 
        835                 840                 845             


Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn 
    850                 855                 860                 


Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu 
865                 870                 875                 880 


Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe 
                885                 890                 895     


Val His Ile Val Gln Met Phe Ile Asn Thr Ser Glu Gly Arg Gly Ser 
            900                 905                 910         


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asp Gln 
        915                 920                 925             


Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp Leu Ala Glu 
    930                 935                 940                 


Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val Phe Leu Ser 
945                 950                 955                 960 


Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly Asn Leu Leu 
                965                 970                 975     


Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser Val Thr Asp 
            980                 985                 990         


Ile Tyr Leu Leu Asn Leu Ala Leu  Ser Asp Leu Leu Phe  Val Ala Thr 
        995                 1000                 1005             


Leu Pro  Phe Trp Thr His Tyr  Leu Ile Asn Glu Lys  Gly Leu His 
    1010                 1015                 1020             


Asn Ala  Met Cys Lys Phe Thr  Thr Ala Phe Phe Phe  Ile Gly Phe 
    1025                 1030                 1035             


Phe Gly  Ser Ile Phe Phe Ile  Thr Val Ile Ser Ile  Asp Arg Tyr 
    1040                 1045                 1050             


Leu Ala  Ile Val Leu Ala Ala  Asn Ser Met Asn Asn  Arg Thr Val 
    1055                 1060                 1065             


Gln His  Gly Val Thr Ile Ser  Leu Gly Val Trp Ala  Ala Ala Ile 
    1070                 1075                 1080             


Leu Val  Ala Ala Pro Gln Phe  Met Phe Thr Lys Gln  Lys Glu Asn 
    1085                 1090                 1095             


Glu Cys  Leu Gly Asp Tyr Pro  Glu Val Leu Gln Glu  Ile Trp Pro 
    1100                 1105                 1110             


Val Leu  Arg Asn Val Glu Thr  Asn Phe Leu Gly Phe  Leu Leu Pro 
    1115                 1120                 1125             


Leu Leu  Ile Met Ser Tyr Cys  Tyr Phe Arg Ile Ile  Gln Thr Leu 
    1130                 1135                 1140             


Phe Ser  Cys Lys Asn His Lys  Lys Ala Lys Ala Ile  Lys Leu Ile 
    1145                 1150                 1155             


Leu Leu  Val Val Ile Val Phe  Phe Leu Phe Trp Thr  Pro Tyr Asn 
    1160                 1165                 1170             


Val Met  Ile Phe Leu Glu Thr  Leu Lys Leu Tyr Asp  Phe Phe Pro 
    1175                 1180                 1185             


Ser Cys  Asp Met Arg Lys Asp  Leu Arg Leu Ala Leu  Ser Val Thr 
    1190                 1195                 1200             


Glu Thr  Val Ala Phe Ser His  Cys Cys Leu Asn Pro  Leu Ile Tyr 
    1205                 1210                 1215             


Ala Phe  Ala Gly Glu Lys Phe  Arg Arg Tyr Leu Tyr  His Leu Tyr 
    1220                 1225                 1230             


Gly Lys  Cys Leu Ala Val Leu  Cys Gly Arg Ser Val  His Val Asp 
    1235                 1240                 1245             


Phe Ser  Ser Ser Glu Ser Gln  Arg Ser Arg His Gly  Ser Val Leu 
    1250                 1255                 1260             


Ser Ser  Asn Phe Thr Tyr His  Thr Ser Asp Gly Asp  Ala Leu Leu 
    1265                 1270                 1275             


Leu Leu  
    1280 


<210>  22
<211>  5048
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22
gagtaattca tacaaaagga ctcgcccctg ccttggggaa tcccagggac cgtcgttaaa       60

ctcccactaa cgtagaaccc agagatcgct gcgttcccgc cccctcaccc gcccgctctc      120

gtcatcactg aggtggagaa gagcatgcgt gaggctccgg tgcccgtcag tgggcagagc      180

gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga accggtgcct      240

agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc      300

ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca      360

acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct      420

ttacgggtta tggcccttgc gtgccttgaa ttacttccac gcccctggct gcagtacgtg      480

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      540

ggagcccctt cgcctcgtgc ttgagttgag gcctggcttg ggcgctgggg ccgccgcgtg      600

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      660

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      720

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      780

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg      840

gggtagtctc aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc      900

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg      960

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1020

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1080

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1140

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1200

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1260

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1320

tttcaggtgt cgtgattcga attcgccacc atggctctgc ctgtgacagc tctgctgctg     1380

cctctggctc tgcttctgca tgctgccaga cctctgttca atcaagaggt gcagatcctg     1440

tcctaagaac tggatctgct acaagaacaa ctgctaccag ttcttcgacg agagcaagaa     1500

ttggtacgag agccaggcca gctgcatgag ccagaatgcc agcctgctga aggtgtacag     1560

caaagaggac caggatctgc tgaagctggt caagagctac cactggatgg gcctcgtgca     1620

catccctacc aatggctctt ggcagtggga ggacggcagc attctgagcc ctaacctgct     1680

gaccatcatc gagatgcaga agggcgactg cgccctgtac gccagcagct ttaagggcta     1740

catcgagaac tgcagcaccc ctaacaccta catctgtatg cagcggaccg tgaccacgac     1800

gccagcgccg cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg     1860

cccagaagcg tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc     1920

ctgtgatatc tacatttggg cccctctggc tggtacttgc ggggtcctgc tgctttcact     1980

cgtgatcact ctttactgta agcgcggtcg gaagaagctg ctgtacatct ttaagcaacc     2040

cttcatgagg cctgtgcaga ctactcaaga ggaggacggc tgttcatgcc ggttcccaga     2100

ggaggaggaa ggcggctgcg aactgcgcgt gaaattcagc cgcagcgcag atgctccagc     2160

ctacaagcag gggcagaacc agctctacaa cgaactcaat cttggtcgga gagaggagta     2220

cgacgtgctg gacaagcgga gaggacggga cccagaaatg ggcgggaagc cgcgcagaaa     2280

gaatccccaa gagggcctgt acaacgagct ccaaaaggat aagatggcag aagcctatag     2340

cgagattggt atgaaagggg aacgcagaag aggcaaaggc caagggcaga ggcagcctgc     2400

tgacatgtgg cgacgtggaa gagaaccctg gccccatgtg gctgcagagc ctgctgctct     2460

tgggcactgt ggcctgcagc atctctcgca aagtgtgtaa cggaataggt attggtgaat     2520

ttaaagactc actctccata aatgctacga atattaaaca cttcaaaaac tgcacctcca     2580

tcagtggcga tctccacatc ctgccggtgg catttagggg tgactccttc acacatactc     2640

ctcctctgga tccacaggaa ctggatattc tgaaaaccgt aaaggaaatc acagggtttt     2700

tgctgattca ggcttggcct gaaaacagga cggacctcca tgcctttgag aacctagaaa     2760

tcatacgcgg caggaccaag caacatggtc agttttctct tgcagtcgtc agcctgaaca     2820

taacatcctt gggattacgc tccctcaagg agataagtga tggagatgtg ataatttcag     2880

gaaacaaaaa tttgtgctat gcaaatacaa taaactggaa aaaactgttt gggacctccg     2940

gtcagaaaac caaaattata agcaacagag gtgaaaacag ctgcaaggcc acaggccagg     3000

tctgccatgc cttgtgctcc cccgagggct gctggggccc ggagcccagg gactgcgtct     3060

cttgccggaa tgtcagccga ggcagggaat gcgtggacaa gtgcaacctt ctggagggtg     3120

agccaaggga gtttgtggag aactctgagt gcatacagtg ccacccagag tgcctgcctc     3180

aggccatgaa catcacctgc acaggacggg gaccagacaa ctgtatccag tgtgcccact     3240

acattgacgg cccccactgc gtcaagacct gcccggcagg agtcatggga gaaaacaaca     3300

ccctggtctg gaagtacgca gacgccggcc atgtgtgcca cctgtgccat ccaaactgca     3360

cctacggatg cactgggcca ggtcttgaag gctgtccaac gaatgggcct aagatcccgt     3420

ccatcgccac tgggatggtg ggggccctcc tcttgctgct ggtggtggcc ctggggatcg     3480

gcctcttcat gcccggggag ggcagaggca gcctgctgac atgtggcgac gtggaagaga     3540

accctggccc catgtaccgg atgcagctgc tgagctgtat cgccctgtct ctggccctgg     3600

tcacaaactc tggcgccaac tgggtcaacg tgatcagcga cctgaagaag atcgaggacc     3660

tgatccagag catgcacatc gacgccacac tgtacaccga gagcgacgtg caccctagct     3720

gtaaagtgac cgccatgaag tgctttctgc tggaactgca agtgatcagc ctggaaagcg     3780

gcgacgccag catccacgac accgtggaaa acctgatcat cctggccaac aacagcctga     3840

gcagcaacgg caatgtgacc gagtccggct gcaaagagtg cgaggaactg gaagagaaga     3900

atatcaaaga gttcctgcag agcttcgtgc acatcgtgca gatgttcatc aacaccagcg     3960

agggcagagg cagcctgctg acatgtggcg acgtggaaga gaaccctggc cccatggatc     4020

agttccccga gagcgtgacc gagaacttcg agtacgatga tctggccgag gcctgctaca     4080

tcggcgacat cgtggtgttc ggcaccgtgt ttctgagcat cttctacagc gtgatcttcg     4140

ccatcggcct cgtgggcaat ctgctggtgg tgtttgccct gaccaacagc aagaaaccca     4200

agtccgtgac cgacatctac ctgctgaatc tggccctgag cgacctgctg ttcgtggcca     4260

cactgccttt ctggacccac tacctgatca acgagaaggg cctgcacaac gccatgtgca     4320

agttcaccac cgcctttttc ttcatcggct ttttcggctc catcttcttc atcaccgtga     4380

tcagcatcga ccgctacctg gccattgtgc tggccgccaa cagcatgaac aaccggacag     4440

ttcagcacgg cgtgaccatc agccttggag tttgggccgc tgccattctg gttgccgctc     4500

ctcagttcat gttcaccaag cagaaagaaa acgagtgcct gggcgactac cccgaggtgc     4560

tgcaagaaat ttggcccgtg ctgcggaacg tggaaacaaa cttcctgggc ttcctgctgc     4620

ctctgctgat catgagctac tgctacttcc ggatcatcca gacactgttc agctgcaaaa     4680

accacaagaa ggccaaggcc atcaagctga tcctgctggt cgtgatcgtg ttcttcctgt     4740

tctggacacc ctacaacgtg atgatcttcc tggaaaccct gaagctgtac gacttcttcc     4800

cctcctgcga catgcggaag gatctgagac tggccctgtc cgtgacagag acagtggcct     4860

tcagccactg ctgcctgaat cctctgatct acgcctttgc cggcgagaag ttcagaagat     4920

acctgtacca cctgtacggc aagtgcctgg ctgtgctgtg tggcagatcc gtgcacgtgg     4980

actttagcag cagcgagagc cagagaagca gacacggctc tgtgctgagc agcaacttca     5040

cctaccac                                                              5048


<210>  23
<211>  907
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
225                 230                 235                 240 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                245                 250                 255     


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            260                 265                 270         


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
        275                 280                 285             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    290                 295                 300                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
305                 310                 315                 320 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                325                 330                 335     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            340                 345                 350         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        355                 360                 365             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Pro Gly Glu Gly Arg 
    370                 375                 380                 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
385                 390                 395                 400 


Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile Ser 
                405                 410                 415     


Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
            420                 425                 430         


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
        435                 440                 445             


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
    450                 455                 460                 


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
465                 470                 475                 480 


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
                485                 490                 495     


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
            500                 505                 510         


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
        515                 520                 525             


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
    530                 535                 540                 


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
545                 550                 555                 560 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
                565                 570                 575     


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
            580                 585                 590         


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
        595                 600                 605             


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
    610                 615                 620                 


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
625                 630                 635                 640 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
                645                 650                 655     


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
            660                 665                 670         


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
        675                 680                 685             


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
    690                 695                 700                 


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
705                 710                 715                 720 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
                725                 730                 735     


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Pro 
            740                 745                 750         


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
        755                 760                 765             


Pro Gly Pro Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser 
    770                 775                 780                 


Leu Ala Leu Val Thr Asn Ser Gly Ala Asn Trp Val Asn Val Ile Ser 
785                 790                 795                 800 


Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala 
                805                 810                 815     


Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala 
            820                 825                 830         


Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly 
        835                 840                 845             


Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn 
    850                 855                 860                 


Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu 
865                 870                 875                 880 


Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe 
                885                 890                 895     


Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            900                 905         


<210>  24
<211>  1126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
225                 230                 235                 240 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                245                 250                 255     


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            260                 265                 270         


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
        275                 280                 285             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    290                 295                 300                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
305                 310                 315                 320 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                325                 330                 335     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            340                 345                 350         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        355                 360                 365             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Pro Gly Glu Gly Arg 
    370                 375                 380                 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
385                 390                 395                 400 


Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile Ser 
                405                 410                 415     


Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
            420                 425                 430         


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
        435                 440                 445             


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
    450                 455                 460                 


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
465                 470                 475                 480 


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
                485                 490                 495     


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
            500                 505                 510         


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
        515                 520                 525             


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
    530                 535                 540                 


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
545                 550                 555                 560 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
                565                 570                 575     


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
            580                 585                 590         


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
        595                 600                 605             


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
    610                 615                 620                 


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
625                 630                 635                 640 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
                645                 650                 655     


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
            660                 665                 670         


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
        675                 680                 685             


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
    690                 695                 700                 


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
705                 710                 715                 720 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
                725                 730                 735     


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Pro 
            740                 745                 750         


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
        755                 760                 765             


Pro Gly Pro Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu 
    770                 775                 780                 


Tyr Asp Asp Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe 
785                 790                 795                 800 


Gly Thr Val Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly 
                805                 810                 815     


Leu Val Gly Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys 
            820                 825                 830         


Pro Lys Ser Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp 
        835                 840                 845             


Leu Leu Phe Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn 
    850                 855                 860                 


Glu Lys Gly Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe 
865                 870                 875                 880 


Phe Ile Gly Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile 
                885                 890                 895     


Asp Arg Tyr Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg 
            900                 905                 910         


Thr Val Gln His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala 
        915                 920                 925             


Ile Leu Val Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn 
    930                 935                 940                 


Glu Cys Leu Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val 
945                 950                 955                 960 


Leu Arg Asn Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu 
                965                 970                 975     


Ile Met Ser Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys 
            980                 985                 990         


Lys Asn His Lys Lys Ala Lys Ala  Ile Lys Leu Ile Leu  Leu Val Val 
        995                 1000                 1005             


Ile Val  Phe Phe Leu Phe Trp  Thr Pro Tyr Asn Val  Met Ile Phe 
    1010                 1015                 1020             


Leu Glu  Thr Leu Lys Leu Tyr  Asp Phe Phe Pro Ser  Cys Asp Met 
    1025                 1030                 1035             


Arg Lys  Asp Leu Arg Leu Ala  Leu Ser Val Thr Glu  Thr Val Ala 
    1040                 1045                 1050             


Phe Ser  His Cys Cys Leu Asn  Pro Leu Ile Tyr Ala  Phe Ala Gly 
    1055                 1060                 1065             


Glu Lys  Phe Arg Arg Tyr Leu  Tyr His Leu Tyr Gly  Lys Cys Leu 
    1070                 1075                 1080             


Ala Val  Leu Cys Gly Arg Ser  Val His Val Asp Phe  Ser Ser Ser 
    1085                 1090                 1095             


Glu Ser  Gln Arg Ser Arg His  Gly Ser Val Leu Ser  Ser Asn Phe 
    1100                 1105                 1110             


Thr Tyr  His Thr Ser Asp Gly  Asp Ala Leu Leu Leu  Leu 
    1115                 1120                 1125     


