                         SEQUENCE LISTING

<110>  Board of Trustees of Michigan State University
 
<120>  Irisin Improves Placental Function During Pregnancy

<130>  6550-000355-WO-POA (TEC2019-00127-01)

<150>  62/819,239
<151>  2019-03-15

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Pro Gly Ser Pro Ser Ala Trp Pro Pro Arg Ala Arg Ala Ala 
1               5                   10                  15      


Leu Arg Leu Trp Leu Gly Cys Val Cys Phe Ala Leu Val Gln Ala Asp 
            20                  25                  30          


Ser Pro Ser Ala Pro Val Asn Val Thr Val Arg His Leu Lys Ala Asn 
        35                  40                  45              


Ser Ala Val Val Ser Trp Asp Val Leu Glu Asp Glu Val Val Ile Gly 
    50                  55                  60                  


Phe Ala Ile Ser Gln Gln Lys Lys Asp Val Arg Met Leu Arg Phe Ile 
65                  70                  75                  80  


Gln Glu Val Asn Thr Thr Thr Arg Ser Cys Ala Leu Trp Asp Leu Glu 
                85                  90                  95      


Glu Asp Thr Glu Tyr Ile Val His Val Gln Ala Ile Ser Ile Gln Gly 
            100                 105                 110         


Gln Ser Pro Ala Ser Glu Pro Val Leu Phe Lys Thr Pro Arg Glu Ala 
        115                 120                 125             


Glu Lys Met Ala Ser Lys Asn Lys Asp Glu Val Thr Met Lys Glu Met 
    130                 135                 140                 


Gly Arg Asn Gln Gln Leu Arg Thr Gly Glu Val Leu Ile Ile Val Val 
145                 150                 155                 160 


Val Leu Phe Met Trp Ala Gly Val Ile Ala Leu Phe Cys Arg Gln Tyr 
                165                 170                 175     


Asp Ile Ile Lys Asp Asn Glu Pro Asn Asn Asn Lys Glu Lys Thr Lys 
            180                 185                 190         


Ser Ala Ser Glu Thr Ser Thr Pro Glu His Gln Gly Gly Gly Leu Leu 
        195                 200                 205             


Arg Ser Lys Ile 
    210         


<210>  2
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNDC5 signal sequence

<400>  2

Met His Pro Gly Ser Pro Ser Ala Trp Pro Pro Arg Ala Arg Ala Ala 
1               5                   10                  15      


Leu Arg Leu Trp Leu Gly Cys Val Cys Phe Ala Leu Val Gln Ala 
            20                  25                  30      


<210>  3
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  irisn

<400>  3

Asp Ser Pro Ser Ala Pro Val Asn Val Thr Val Arg His Leu Lys Ala 
1               5                   10                  15      


Asn Ser Ala Val Val Ser Trp Asp Val Leu Glu Asp Glu Val Val Ile 
            20                  25                  30          


Gly Phe Ala Ile Ser Gln Gln Lys Lys Asp Val Arg Met Leu Arg Phe 
        35                  40                  45              


Ile Gln Glu Val Asn Thr Thr Thr Arg Ser Cys Ala Leu Trp Asp Leu 
    50                  55                  60                  


Glu Glu Asp Thr Glu Tyr Ile Val His Val Gln Ala Ile Ser Ile Gln 
65                  70                  75                  80  


Gly Gln Ser Pro Ala Ser Glu Pro Val Leu Phe Lys Thr Pro Arg Glu 
                85                  90                  95      


Ala Glu Lys Met Ala Ser Lys Asn Lys Asp Glu Val Thr Met Lys Glu 
            100                 105                 110         


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNDC5 spacer

<400>  4

Met Gly Arg Asn Gln Gln Leu Arg Thr 
1               5                   


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNDC5 transmembrane region

<400>  5

Gly Glu Val Leu Ile Ile Val Val Val Leu Phe Met Trp Ala Gly Val 
1               5                   10                  15      


Ile Ala Leu Phe Cys 
            20      


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNDC5 cytoplasmic domain

<400>  6

Arg Gln Tyr Asp Ile Ile Lys Asp Asn Glu Pro Asn Asn Asn Lys Glu 
1               5                   10                  15      


Lys Thr Lys Ser Ala Ser Glu Thr Ser Thr Pro Glu His Gln Gly Gly 
            20                  25                  30          


Gly Leu Leu Arg Ser Lys Ile 
        35                  


