                         SEQUENCE LISTING

<110>  ModernaTX, Inc.
       The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
 
<120>  HIV RNA VACCINES

<130>  M1378.70116WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/819,394
<151>  2019-03-15

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  856
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             


Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 


Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Lys 
            180                 185                 190         


Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
    210                 215                 220                 


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr 
225                 230                 235                 240 


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
            260                 265                 270         


Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu 
        275                 280                 285             


Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg 
    290                 295                 300                 


Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile 
305                 310                 315                 320 


Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
            340                 345                 350         


Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp 
        355                 360                 365             


Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu 
    450                 455                 460                 


Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
            580                 585                 590         


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val 
        595                 600                 605             


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn 
    610                 615                 620                 


His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 
625                 630                 635                 640 


Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
                645                 650                 655     


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
            660                 665                 670         


Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His 
705                 710                 715                 720 


Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Glu Arg Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Ser 
            740                 745                 750         


Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
        755                 760                 765             


His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu 
    770                 775                 780                 


Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu 
785                 790                 795                 800 


Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn 
                805                 810                 815     


Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val 
            820                 825                 830         


Val Gln Gly Ala Cys Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Gly Leu Glu Arg Ile Leu Leu 
    850                 855     


<210>  2
<211>  849
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Lys Val Met Gly Thr Lys Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Ile Met Leu Leu Gly Met Leu Met Met Ser Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Asn 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Met Gly Asn Val Thr Glu Asp Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


His Cys Thr Asn Val Thr Ile Ser Ser Thr Asn Gly Ser Thr Ala Asn 
    130                 135                 140                 


Val Thr Met Arg Glu Gly Met Lys Asn Cys Ser Phe Asn Thr Thr Thr 
145                 150                 155                 160 


Val Ile Arg Asp Lys Ile Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu 
                165                 170                 175     


Asp Ile Val Pro Ile Glu Gly Lys Asn Thr Asn Thr Ser Tyr Arg Leu 
            180                 185                 190         


Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser 
        195                 200                 205             


Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile 
    210                 215                 220                 


Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Arg Asn 
225                 230                 235                 240 


Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr 
                245                 250                 255     


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Asp Ile Ile Ile Arg 
            260                 265                 270         


Ser Glu Asn Phe Thr Asn Asn Gly Lys Asn Ile Ile Val Gln Leu Lys 
        275                 280                 285             


Glu Pro Val Lys Ile Asn Cys Thr Arg Pro Gly Asn Asn Thr Arg Arg 
    290                 295                 300                 


Ser Ile Asn Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Ala Ile 
305                 310                 315                 320 


Ile Gly Asp Ile Arg Lys Ala His Cys Asn Ile Ser Thr Glu Gln Trp 
                325                 330                 335     


Asn Asn Thr Leu Thr Gln Ile Val Asp Lys Leu Arg Glu Gln Phe Gly 
            340                 345                 350         


Asn Lys Thr Ile Ile Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Val 
        355                 360                 365             


Val Met His Thr Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
    370                 375                 380                 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Asn Gly Thr Ser Thr Trp 
385                 390                 395                 400 


Asn Ser Thr Ala Asp Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Val 
                405                 410                 415     


Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile 
            420                 425                 430         


Arg Gly Gln Ile Asp Cys Ser Ser Asn Ile Thr Gly Leu Ile Leu Thr 
        435                 440                 445             


Arg Asp Gly Gly Ser Asn Ser Ser Gln Asn Glu Thr Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Lys Ile Glu Pro Leu Gly Ile Ala Pro Thr Arg Ala Lys Arg 
                485                 490                 495     


Arg Val Val Gln Arg Glu Lys Arg Ala Val Thr Leu Gly Ala Val Phe 
            500                 505                 510         


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu 
        515                 520                 525             


Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln 
    530                 535                 540                 


Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln 
545                 550                 555                 560 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile 
                565                 570                 575     


Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
            580                 585                 590         


Gly Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Thr Ser Trp Ser 
        595                 600                 605             


Asn Lys Ser Tyr Asp Tyr Ile Trp Asn Asn Met Thr Trp Met Gln Trp 
    610                 615                 620                 


Glu Arg Glu Ile Asp Asn Tyr Thr Gly Phe Ile Tyr Thr Leu Ile Glu 
625                 630                 635                 640 


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Leu Glu Leu Leu Glu Leu 
                645                 650                 655     


Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu 
            660                 665                 670         


Trp Tyr Ile Lys Leu Phe Ile Met Ile Ile Gly Gly Leu Val Gly Leu 
        675                 680                 685             


Arg Thr Val Cys Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly 
    690                 695                 700                 


Tyr Ser Pro Leu Ser Phe Gln Thr Arg Leu Pro Asn Pro Arg Gly Pro 
705                 710                 715                 720 


Gly Arg Pro Glu Glu Thr Glu Gly Glu Gly Gly Glu Arg Asp Arg Asp 
                725                 730                 735     


Arg Ser Ala Arg Leu Val Asn Gly Phe Leu Ala Ile Ile Trp Asp Asp 
            740                 745                 750         


Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu 
        755                 760                 765             


Leu Ile Val Ala Arg Val Val Glu Ile Leu Gly Arg Arg Gly Trp Glu 
    770                 775                 780                 


Ile Leu Lys Tyr Trp Trp Asn Leu Leu Lys Tyr Trp Ser Gln Glu Leu 
785                 790                 795                 800 


Lys Asn Ser Ala Val Ser Leu Leu Asn Val Thr Ala Ile Ala Val Ala 
                805                 810                 815     


Glu Gly Thr Asp Arg Val Ile Glu Ile Val Gln Arg Ala Val Arg Ala 
            820                 825                 830         


Ile Leu His Ile Pro Thr Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu 
        835                 840                 845             


Leu 
    


<210>  3
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Arg Val Arg Gly Ile Pro Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Ile Ile Ile Cys Arg Val Val Gly Asn 
            20                  25                  30          


Leu Asp Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
        35                  40                  45              


Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Lys 
    50                  55                  60                  


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
65                  70                  75                  80  


Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
                85                  90                  95      


Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu 
            100                 105                 110         


Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
        115                 120                 125             


Thr Leu Asn Cys Lys Asn Val Asn Ile Ser Ala Asn Ala Asn Ala Thr 
    130                 135                 140                 


Ala Thr Leu Asn Ser Ser Met Asn Gly Glu Ile Lys Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Thr Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val Tyr Ala Leu 
                165                 170                 175     


Phe Tyr Lys Pro Asp Val Val Pro Leu Asn Gly Gly Glu His Asn Glu 
            180                 185                 190         


Thr Gly Glu Tyr Ile Leu Ile Asn Cys Asn Ser Ser Thr Ile Thr Gln 
        195                 200                 205             


Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala 
    210                 215                 220                 


Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
225                 230                 235                 240 


Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
                245                 250                 255     


Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Glu Glu Ile Ile Val Arg Ser Glu Asn Leu Thr Asn Asn Ile Lys Thr 
        275                 280                 285             


Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Lys Cys Thr Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro Gly Gln Thr Phe 
305                 310                 315                 320 


Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Glu Ala His Cys Asn 
                325                 330                 335     


Ile Ser Arg Glu Thr Trp Asn Ser Thr Leu Ile Gln Val Lys Glu Lys 
            340                 345                 350         


Leu Arg Glu His Tyr Asn Lys Thr Ile Lys Phe Glu Pro Ser Ser Gly 
        355                 360                 365             


Gly Asp Leu Glu Val Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
    370                 375                 380                 


Phe Tyr Cys Asp Thr Thr Lys Leu Phe Asn Glu Thr Lys Leu Phe Asn 
385                 390                 395                 400 


Glu Ser Glu Tyr Val Asp Asn Lys Thr Ile Ile Leu Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Glu Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Leu Leu Thr Trp Asp Gly Gly Glu Asn Ser Thr Glu Gly Val Phe Arg 
    450                 455                 460                 


Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
465                 470                 475                 480 


Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr Lys Ser 
                485                 490                 495     


Lys Arg Lys Val Val Gly Arg Glu Lys Arg Ala Val Gly Leu Gly Ala 
            500                 505                 510         


Val Leu Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
        515                 520                 525             


Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
    530                 535                 540                 


Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu 
545                 550                 555                 560 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu 
                565                 570                 575     


Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly 
            580                 585                 590         


Cys Ser Gly Lys Leu Ile Cys Ala Thr Ala Val Pro Trp Asn Ser Ser 
        595                 600                 605             


Trp Ser Asn Lys Ser Leu Gly Asp Ile Trp Asp Asn Met Thr Trp Met 
    610                 615                 620                 


Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asn Thr Ile Phe Arg Leu 
625                 630                 635                 640 


Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu 
                645                 650                 655     


Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn Trp Phe Asp Ile Thr Asn 
            660                 665                 670         


Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile 
        675                 680                 685             


Gly Leu Arg Ile Ile Phe Gly Val Leu Ala Ile Val Lys Arg Val Arg 
    690                 695                 700                 


Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Ile Pro Asn Pro Arg 
705                 710                 715                 720 


Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp 
                725                 730                 735     


Lys Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp 
            740                 745                 750         


Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Gln Leu Arg Asp 
        755                 760                 765             


Phe Ile Leu Thr Ala Ala Arg Ala Ala Glu Leu Leu Gly Arg Ser Ser 
    770                 775                 780                 


Leu Arg Gly Leu Gln Arg Gly Trp Glu Val Leu Lys Tyr Leu Gly Asn 
785                 790                 795                 800 


Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Arg Ser Ala Ile Asn Leu 
                805                 810                 815     


Phe Asp Thr Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile 
            820                 825                 830         


Glu Val Ile Gln Arg Ile Cys Arg Ala Ile Arg Tyr Ile Pro Thr Arg 
        835                 840                 845             


Ile Arg Gln Gly Phe Glu Ala Ala Leu Leu 
    850                 855             


<210>  4
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln His Leu Phe Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Ile Ile Ile Cys Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Gln Cys Thr Asn Val Thr Asn Asn Ile Thr Asp Asp Met Arg Gly Glu 
    130                 135                 140                 


Leu Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys 
145                 150                 155                 160 


Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val Val Gln Ile Asn 
                165                 170                 175     


Glu Asn Gln Gly Asn Arg Ser Asn Asn Ser Asn Lys Glu Tyr Arg Leu 
            180                 185                 190         


Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser 
        195                 200                 205             


Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile 
    210                 215                 220                 


Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Pro Ser 
225                 230                 235                 240 


Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr 
                245                 250                 255     


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Met Ile Arg 
            260                 265                 270         


Ser Glu Asn Ile Thr Asn Asn Ala Lys Asn Ile Leu Val Gln Phe Asn 
        275                 280                 285             


Thr Pro Val Gln Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys 
    290                 295                 300                 


Ser Ile Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile 
305                 310                 315                 320 


Ile Gly Asp Ile Arg Gln Ala His Cys Thr Val Ser Lys Ala Thr Trp 
                325                 330                 335     


Asn Glu Thr Leu Gly Lys Val Val Lys Gln Leu Arg Lys His Phe Gly 
            340                 345                 350         


Asn Asn Thr Ile Ile Arg Phe Ala Asn Ser Ser Gly Gly Asp Leu Glu 
        355                 360                 365             


Val Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Ser Gly Leu Phe Asn Ser Thr Trp Ile Ser Asn Thr Ser Val Gln 
385                 390                 395                 400 


Gly Ser Asn Ser Thr Gly Ser Asn Asp Ser Ile Thr Leu Pro Cys Arg 
                405                 410                 415     


Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Ile Gly Gln Ala Met Tyr 
            420                 425                 430         


Ala Pro Pro Ile Gln Gly Val Ile Arg Cys Val Ser Asn Ile Thr Gly 
        435                 440                 445             


Leu Ile Leu Thr Arg Asp Gly Gly Ser Thr Asn Ser Thr Thr Glu Thr 
    450                 455                 460                 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
465                 470                 475                 480 


Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr 
                485                 490                 495     


Arg Ala Lys Arg Arg Val Val Gly Arg Glu Lys Arg Ala Val Gly Ile 
            500                 505                 510         


Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
        515                 520                 525             


Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Asn Leu Leu Ser Gly 
    530                 535                 540                 


Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln 
545                 550                 555                 560 


His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg 
                565                 570                 575     


Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile 
            580                 585                 590         


Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn 
        595                 600                 605             


Ser Ser Trp Ser Asn Arg Asn Leu Ser Glu Ile Trp Asp Asn Met Thr 
    610                 615                 620                 


Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Gln Ile Ile Tyr 
625                 630                 635                 640 


Gly Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp 
                645                 650                 655     


Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
            660                 665                 670         


Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly 
        675                 680                 685             


Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Val Ile His Arg 
    690                 695                 700                 


Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Thr Pro Asn 
705                 710                 715                 720 


Pro Arg Gly Leu Asp Arg Pro Glu Arg Ile Glu Glu Glu Asp Gly Glu 
                725                 730                 735     


Gln Asp Arg Gly Arg Ser Thr Arg Leu Val Ser Gly Phe Leu Ala Leu 
            740                 745                 750         


Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Cys Tyr His Arg Leu 
        755                 760                 765             


Arg Asp Phe Ile Leu Ile Ala Ala Arg Ile Val Glu Leu Leu Gly His 
    770                 775                 780                 


Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu 
785                 790                 795                 800 


Trp Asn Leu Leu Ala Tyr Trp Gly Arg Glu Leu Lys Ile Ser Ala Ile 
                805                 810                 815     


Asn Leu Phe Asp Thr Ile Ala Ile Ala Val Ala Glu Trp Thr Asp Arg 
            820                 825                 830         


Val Ile Glu Ile Gly Gln Arg Leu Cys Arg Ala Phe Leu His Ile Pro 
        835                 840                 845             


Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
    850                 855                 860 


<210>  5
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Ile Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Thr Ala Arg Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser Tyr Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Ser Gly Val Glu Thr Thr Thr Pro Pro Gln Lys Gln Glu Pro Ile Asp 
465                 470                 475                 480 


Lys Glu Leu Tyr Pro Leu Thr Ser Leu Arg Ser Leu Phe Gly Asn Asp 
                485                 490                 495     


Pro Ser Ser Gln 
            500 


<210>  6
<211>  4307
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcaatta aaggaagctc tattagatac aggagcagat gatacagtat     1560

tagaagaaat gaatttgcca ggaagatgga aaccaaaaat gataggggga attggaggtt     1620

ttatcaaagt aagacagtat gatcagatac tcatagaaat ctgcggacat aaagctatag     1680

gtacagtatt agtaggacct acacctgtca acataattgg aagaaatctg ttgactcaga     1740

ttggctgcac tttaaatttt cccattagtc ctattgagac tgtaccagta aaattaaagc     1800

caggaatgga tggcccaaaa gttaaacaat ggccattgac agaagaaaaa ataaaagcat     1860

tagtagaaat ttgtacagaa atggaaaagg aaggaaaaat ttcaaaaatt gggcctgaaa     1920

atccatacaa tactccagta tttgccataa agaaaaaaga cagtactaaa tggagaaaat     1980

tagtagattt cagagaactt aataagagaa ctcaagattt ctgggaagtt caattaggaa     2040

taccacatcc tgcagggtta aaacagaaaa aatcagtaac agtactggat gtgggcgatg     2100

catatttttc agttccctta gataaagact tcaggaagta tactgcattt accataccta     2160

gtataaacaa tgagacacca gggattagat atcagtacaa tgtgcttcca cagggatgga     2220

aaggatcacc agcaatattc cagtgtagca tgacaaaaat cttagagcct tttagaaaac     2280

aaaatccaga catagtcatc tatcaataca tggatgattt gtatgtagga tctgacttag     2340

aaatagggca gcatagaaca aaaatagagg aactgagaca acatctgttg aggtggggat     2400

ttaccacacc agacaaaaaa catcagaaag aacctccatt cctttggatg ggttatgaac     2460

tccatcctga taaatggaca gtacagccta tagtgctgcc agaaaaggac agctggactg     2520

tcaatgacat acagaaatta gtgggaaaat tgaattgggc aagtcagatt tatgcaggga     2580

ttaaagtaag gcaattatgt aaacttctta ggggaaccaa agcactaaca gaagtagtac     2640

cactaacaga agaagcagag ctagaactgg cagaaaacag ggagattcta aaagaaccgg     2700

tacatggagt gtattatgac ccatcaaaag acttaatagc agaaatacag aagcaggggc     2760

aaggccaatg gacatatcaa atttatcaag agccatttaa aaatctgaaa acaggaaagt     2820

atgcaagaat gaagggtgcc cacactaatg atgtgaaaca attaacagag gcagtacaaa     2880

aaatagccac agaaagcata gtaatatggg gaaagactcc taaatttaaa ttacccatac     2940

aaaaggaaac atgggaagca tggtggacag agtattggca agccacctgg attcctgagt     3000

gggagtttgt caatacccct cccttagtga agttatggta ccagttagag aaagaaccca     3060

taataggagc agaaactttc tatgtagatg gggcagccaa tagggaaact aaattaggaa     3120

aagcaggata tgtaactgac agaggaagac aaaaagttgt ccccctaacg gacacaacaa     3180

atcagaagac tgagttacaa gcaattcatc tagctttgca ggattcggga ttagaagtaa     3240

acatagtgac agactcacaa tatgcattgg gaatcattca agcacaacca gataagagtg     3300

aatcagagtt agtcagtcaa ataatagagc agttaataaa aaaggaaaaa gtctacctgg     3360

catgggtacc agcacacaaa ggaattggag gaaatgaaca agtagataaa ttggtcagtg     3420

ctggaatcag gaaagtacta tttttagatg gaatagataa ggcccaagaa gaacatgaga     3480

aatatcacag taattggaga gcaatggcta gtgattttaa cctaccacct gtagtagcaa     3540

aagaaatagt agccagctgt gataaatgtc agctaaaagg ggaagccatg catggacaag     3600

tagactgtag cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct     3660

tggtagcagt tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag     3720

ggcaagaaac agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac     3780

atacagacaa tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg     3840

ggatcaagca ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta     3900

tgaataaaga attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga     3960

cagcagtaca aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt     4020

acagtgcagg ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac     4080

aaaaacaaat tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag     4140

tttggaaagg accagcaaag ctcctctgga aaggtgaagg ggcagtagta atacaagata     4200

atagtgacat aaaagtagtg ccaagaagaa aagcaaagat catcagggat tatggaaaac     4260

agatggcagg tgatgattgt gtggcaagta gacaggatga ggattaa                   4307


<210>  7
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Pro Gln Ile Thr Leu Trp Lys Arg Pro Leu Val Thr Ile Lys Ile Gly 
1               5                   10                  15      


Gly Gln Leu Lys Glu Ala Leu Leu Asp Thr Gly Ala Asp Asp Thr Val 
            20                  25                  30          


Leu Glu Glu Met Asn Leu Pro Gly Arg Trp Lys Pro Lys Met Ile Gly 
        35                  40                  45              


Gly Ile Gly Gly Phe Ile Lys Val Arg Gln Tyr Asp Gln Ile Leu Ile 
    50                  55                  60                  


Glu Ile Cys Gly His Lys Ala Ile Gly Thr Val Leu Val Gly Pro Thr 
65                  70                  75                  80  


Pro Val Asn Ile Ile Gly Arg Asn Leu Leu Thr Gln Ile Gly Cys Thr 
                85                  90                  95      


Leu Asn Phe 
            


<210>  8
<211>  794
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  9
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Gly Ala Arg Ala Glu Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro 
        35                  40                  45              


Val Trp Lys Asp Ala Glu Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
    50                  55                  60                  


Ala Tyr Glu Thr Glu Lys His Asn Val Trp Ala Thr His Ala Cys Val 
65                  70                  75                  80  


Pro Thr Asp Pro Asn Pro Gln Glu Ile His Leu Glu Asn Val Thr Glu 
                85                  90                  95      


Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Thr Asp 
            100                 105                 110         


Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr 
        115                 120                 125             


Pro Leu Cys Val Thr Leu Gln Cys Thr Asn Val Thr Asn Asn Ile Thr 
    130                 135                 140                 


Asp Asp Met Arg Gly Glu Leu Lys Asn Cys Ser Phe Asn Met Thr Thr 
145                 150                 155                 160 


Glu Leu Arg Asp Lys Lys Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu 
                165                 170                 175     


Asp Val Val Gln Ile Asn Glu Asn Gln Gly Asn Arg Ser Asn Asn Ser 
            180                 185                 190         


Asn Lys Glu Tyr Arg Leu Ile Cys Asn Thr Ser Ala Ile Thr Gln Ala 
        195                 200                 205             


Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro 
    210                 215                 220                 


Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr 
225                 230                 235                 240 


Gly Pro Cys Pro Ser Val Ser Thr Val Gln Cys Thr His Gly Ile Lys 
                245                 250                 255     


Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu 
            260                 265                 270         


Glu Val Met Ile Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys Asn Ile 
        275                 280                 285             


Leu Val Gln Phe Asn Thr Pro Val Gln Ile Asn Cys Thr Arg Pro Asn 
    290                 295                 300                 


Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Ala Phe Tyr 
305                 310                 315                 320 


Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Val 
                325                 330                 335     


Ser Lys Ala Thr Trp Asn Glu Thr Leu Gly Lys Val Val Lys Gln Leu 
            340                 345                 350         


Arg Lys His Phe Gly Asn Asn Thr Ile Ile Arg Phe Ala Asn Ser Ser 
        355                 360                 365             


Gly Gly Asp Leu Glu Val Thr Thr His Ser Phe Asn Cys Gly Gly Glu 
    370                 375                 380                 


Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr Trp Ile Ser 
385                 390                 395                 400 


Asn Thr Ser Val Gln Gly Ser Asn Ser Thr Gly Ser Asn Asp Ser Ile 
                405                 410                 415     


Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Ile 
            420                 425                 430         


Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile Arg Cys Val 
        435                 440                 445             


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Ser Thr Asn 
    450                 455                 460                 


Ser Thr Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn 
465                 470                 475                 480 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu 
                485                 490                 495     


Gly Val Ala Pro Thr Arg Cys Lys Arg Arg Val Val Gly Arg Arg Arg 
            500                 505                 510         


Arg Arg Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
        515                 520                 525             


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln 
    530                 535                 540                 


Ala Arg Asn Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
545                 550                 555                 560 


Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly 
                565                 570                 575     


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg 
            580                 585                 590         


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
        595                 600                 605             


Cys Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Arg Asn Leu Ser 
    610                 615                 620                 


Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser 
625                 630                 635                 640 


Asn Tyr Thr Gln Ile Ile Tyr Gly Leu Leu Glu Glu Ser Gln Asn Gln 
                645                 650                 655     


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp 
            660                 665             


<210>  10
<211>  47
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  11
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
gggaaauaag agagaaaaga agaguaagaa gaaauauaag accccggcgc cgccacc          57


<210>  12
<211>  119
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaagucuga gugggcggc       119


<210>  13
<211>  119
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaagucuga gugggcggc       119


