                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       YIZHAR, Ofer
       MAHN, Mathias
 
<120>  BISTABLE TYPE II OPSINS AND USES THEREOF

<130>  81591

<150>  IL 265486
<151>  2019-03-19

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Membrane trafficking signal

<400>  1

Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile 
1               5                   10                  15      


Asp Ile Asn Val 
            20  


<210>  2
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ER EXPORT SIGNAL

<400>  2

Phe Cys Tyr Glu Asn Glu Val 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rhodopsin epitope tag

<400>  3

Thr Glu Thr Ser Gln Val Ala Pro Ala 
1               5                   


<210>  4
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker sequence

<400>  4

Pro Arg Ala Arg Asp Pro 
1               5       


<210>  5
<211>  607
<212>  PRT
<213>  Artificial sequence

<220>
<223>  eOPN3-mScarlet open reading frame AA sequence

<400>  5

Met Tyr Asp Ala Pro Asn Asp Val Ala Ser Ser Val Ala Asp Tyr Glu 
1               5                   10                  15      


Asp Leu Met Ala Pro Trp Ala Tyr Asn Ala Ala Ala Ile Thr Leu Phe 
            20                  25                  30          


Phe Ile Gly Phe Phe Gly Phe Phe Leu Asn Leu Phe Val Ile Ala Leu 
        35                  40                  45              


Met Ser Lys Asp Met Gln Leu Trp Thr Pro Met Asn Ile Ile Leu Phe 
    50                  55                  60                  


Asn Leu Val Cys Ser Asp Phe Ser Val Ser Ile Ile Gly Asn Pro Leu 
65                  70                  75                  80  


Thr Leu Thr Ser Ala Ile Ser His Arg Trp Ile Phe Gly Arg Thr Leu 
                85                  90                  95      


Cys Val Ala Tyr Gly Phe Phe Met Ser Leu Leu Gly Ile Thr Ser Ile 
            100                 105                 110         


Thr Thr Leu Thr Val Leu Ser Tyr Glu Arg Tyr Cys Leu Ile Ser Arg 
        115                 120                 125             


Pro Phe Ser Ser Arg Asn Leu Ser Arg Lys Gly Ala Phe Leu Ala Ile 
    130                 135                 140                 


Phe Phe Ile Trp Gly Tyr Ser Phe Ala Leu Thr Ser Pro Pro Leu Phe 
145                 150                 155                 160 


Gly Trp Gly Ala Tyr Val Gln Glu Ala Ala Asn Ile Ser Cys Ser Val 
                165                 170                 175     


Asn Trp Glu Ser Gln Thr Lys Asn Ala Thr Thr Tyr Ile Ile Phe Leu 
            180                 185                 190         


Phe Val Phe Gly Leu Val Val Pro Leu Ile Val Ile Val Tyr Ser Tyr 
        195                 200                 205             


Thr Asn Ile Ile Val Tyr Met Arg Arg Asn Ser Ala Arg Val Gly Arg 
    210                 215                 220                 


Ile Asn Arg Ala Glu Gln Arg Val Thr Ser Met Val Ala Val Met Ile 
225                 230                 235                 240 


Val Ala Phe Met Val Ala Trp Thr Pro Tyr Ala Ile Phe Ala Leu Ile 
                245                 250                 255     


Glu Gln Phe Gly Pro Pro Glu Leu Ile Gly Pro Gly Leu Ala Val Leu 
            260                 265                 270         


Pro Ala Leu Ile Ala Lys Ser Ser Ile Cys Tyr Asn Pro Ile Ile Tyr 
        275                 280                 285             


Val Gly Met Asn Thr Gln Phe Arg Ala Ala Phe Thr Arg Val Arg Asn 
    290                 295                 300                 


Lys Gly Gly Val Pro Thr Ala Asp Gln Asn Thr Thr Thr Met Gln Arg 
305                 310                 315                 320 


Glu Leu Thr Lys Ser Ser Arg Asp Met Val Thr Glu Thr Ser Gln Val 
                325                 330                 335     


Ala Pro Ala Pro Arg Ala Arg Asp Pro Thr Gly Lys Ser Arg Ile Thr 
            340                 345                 350         


Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Val 
        355                 360                 365             


Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 
    370                 375                 380                 


Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
385                 390                 395                 400 


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
                405                 410                 415     


Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 
            420                 425                 430         


Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 
        435                 440                 445             


Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
    450                 455                 460                 


Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 
465                 470                 475                 480 


Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 
                485                 490                 495     


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
            500                 505                 510         


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly 
        515                 520                 525             


Asp Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala 
    530                 535                 540                 


Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly 
545                 550                 555                 560 


Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
                565                 570                 575     


Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr 
            580                 585                 590         


Gly Gly Met Asp Glu Leu Tyr Lys Phe Cys Tyr Glu Asn Glu Val 
        595                 600                 605         


<210>  6
<211>  1824
<212>  DNA
<213>  Artificial sequence

<220>
<223>  eOPN3 nucleic acid sequence

<400>  6
atgtacgacg cccccaacga cgtggccagc agcgtggccg actacgagga cctgatggcc       60

ccctgggcct acaacgccgc cgccatcacc ctgttcttca tcggcttctt cggcttcttc      120

ctgaacctgt tcgtgatcgc cctgatgagc aaggacatgc agctgtggac ccccatgaac      180

atcatcctgt tcaacctggt gtgcagcgac ttcagcgtga gcatcatcgg caaccccctg      240

accctgacca gcgccatcag ccacaggtgg atcttcggca ggaccctgtg cgtggcctac      300

ggcttcttca tgagcctgct gggcatcacc agcatcacca ccctgaccgt gctgagctac      360

gagaggtact gcctgatcag caggcccttc agcagcagga acctgagcag gaagggcgcc      420

ttcctggcca tcttcttcat ctggggctac agcttcgccc tgaccagccc ccccctgttc      480

ggctggggcg cctacgtgca ggaggccgcc aacatcagct gcagcgtgaa ctgggagagc      540

cagaccaaga acgccaccac ctacatcatc ttcctgttcg tgttcggcct ggtggtgccc      600

ctgatcgtga tcgtgtacag ctacaccaac atcatcgtgt acatgaggag gaacagcgcc      660

agggtgggca ggatcaacag ggccgagcag agggtgacca gcatggtggc cgtgatgatc      720

gtggccttca tggtggcctg gaccccctac gccatcttcg ccctgatcga gcagttcggc      780

ccccccgagc tgatcggccc tggactggct gtgctgcctg ctctgatcgc caagagcagc      840

atctgctaca accccatcat ctacgtgggc atgaacaccc agttcagggc cgccttcacc      900

agggtgagga acaagggcgg cgtgcccacc gccgaccaga acaccaccac catgcagagg      960

gagctgacca agagcagcag ggacatggtg accgagacca gccaggtggc tcctgctccg     1020

cgagcccgag atccaaccgg taagagcagg atcaccagcg agggcgagta catccccctg     1080

gaccagatcg acatcaacgt ggtgatggtg agcaagggcg aggcagtgat caaggagttc     1140

atgcggttca aggtgcacat ggagggctcc atgaacggcc acgagttcga gatcgagggc     1200

gagggcgagg gccgccccta cgagggcacc cagaccgcca agctgaaggt gaccaagggt     1260

ggccccctgc ccttctcctg ggacatcctg tcccctcagt tcatgtacgg ctccagggcc     1320

ttcaccaagc accccgccga catccccgac tactataagc agtccttccc cgagggcttc     1380

aagtgggagc gcgtgatgaa cttcgaggac ggcggcgccg tgaccgtgac ccaggacacc     1440

tccctggagg acggcaccct gatctacaag gtgaagctcc gcggcaccaa cttccctcct     1500

gacggccccg taatgcagaa gaagacaatg ggctgggaag cgtccaccga gcggttgtac     1560

cccgaggacg gcgtgctgaa gggcgacatt aagatggccc tgcgcctgaa ggacggcgga     1620

cgctacctgg cggacttcaa gaccacctac aaggccaaga agcccgtgca gatgcccggc     1680

gcctacaacg tcgaccgcaa gttggacatc acctcccaca acgaggacta caccgtggtg     1740

gaacagtacg aacgctccga gggccgccac tccaccggcg gcatggacga gctgtacaag     1800

ttctgctacg agaacgaggt gtaa                                            1824


<210>  7
<211>  696
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mScarlet NA sequence

<400>  7
atggtgagca agggcgaggc agtgatcaag gagttcatgc ggttcaaggt gcacatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggtggcc ccctgccctt ctcctgggac      180

atcctgtccc ctcagttcat gtacggctcc agggccttca ccaagcaccc cgccgacatc      240

cccgactact ataagcagtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gcgccgtgac cgtgacccag gacacctccc tggaggacgg caccctgatc      360

tacaaggtga agctccgcgg caccaacttc cctcctgacg gccccgtaat gcagaagaag      420

acaatgggct gggaagcgtc caccgagcgg ttgtaccccg aggacggcgt gctgaagggc      480

gacattaaga tggccctgcg cctgaaggac ggcggacgct acctggcgga cttcaagacc      540

acctacaagg ccaagaagcc cgtgcagatg cccggcgcct acaacgtcga ccgcaagttg      600

gacatcacct cccacaacga ggactacacc gtggtggaac agtacgaacg ctccgagggc      660

cgccactcca ccggcggcat ggacgagctg tacaag                                696


<210>  8
<211>  429
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mosopn3 aa sequence

<400>  8

Met Tyr Asp Ala Pro Asn Asp Val Ala Ser Ser Val Ala Asp Tyr Glu 
1               5                   10                  15      


Asp Leu Met Ala Pro Trp Ala Tyr Asn Ala Ala Ala Ile Thr Leu Phe 
            20                  25                  30          


Phe Ile Gly Phe Phe Gly Phe Phe Leu Asn Leu Phe Val Ile Ala Leu 
        35                  40                  45              


Met Ser Lys Asp Met Gln Leu Trp Thr Pro Met Asn Ile Ile Leu Phe 
    50                  55                  60                  


Asn Leu Val Cys Ser Asp Phe Ser Val Ser Ile Ile Gly Asn Pro Leu 
65                  70                  75                  80  


Thr Leu Thr Ser Ala Ile Ser His Arg Trp Ile Phe Gly Arg Thr Leu 
                85                  90                  95      


Cys Val Ala Tyr Gly Phe Phe Met Ser Leu Leu Gly Ile Thr Ser Ile 
            100                 105                 110         


Thr Thr Leu Thr Val Leu Ser Tyr Glu Arg Tyr Cys Leu Ile Ser Arg 
        115                 120                 125             


Pro Phe Ser Ser Arg Asn Leu Ser Arg Lys Gly Ala Phe Leu Ala Ile 
    130                 135                 140                 


Phe Phe Ile Trp Gly Tyr Ser Phe Ala Leu Thr Ser Pro Pro Leu Phe 
145                 150                 155                 160 


Gly Trp Gly Ala Tyr Val Gln Glu Ala Ala Asn Ile Ser Cys Ser Val 
                165                 170                 175     


Asn Trp Glu Ser Gln Thr Lys Asn Ala Thr Thr Tyr Ile Ile Phe Leu 
            180                 185                 190         


Phe Val Phe Gly Leu Val Val Pro Leu Ile Val Ile Val Tyr Ser Tyr 
        195                 200                 205             


Thr Asn Ile Ile Val Tyr Met Arg Arg Asn Ser Ala Arg Val Gly Arg 
    210                 215                 220                 


Ile Asn Arg Ala Glu Gln Arg Val Thr Ser Met Val Ala Val Met Ile 
225                 230                 235                 240 


Val Ala Phe Met Val Ala Trp Thr Pro Tyr Ala Ile Phe Ala Leu Ile 
                245                 250                 255     


Glu Gln Phe Gly Pro Pro Glu Leu Ile Gly Pro Gly Leu Ala Val Leu 
            260                 265                 270         


Pro Ala Leu Ile Ala Lys Ser Ser Ile Cys Tyr Asn Pro Ile Ile Tyr 
        275                 280                 285             


Val Gly Met Asn Thr Gln Phe Arg Ala Ala Phe Thr Arg Val Arg Asn 
    290                 295                 300                 


Lys Gly Gly Val Pro Thr Ala Asp Gln Asn Thr Thr Thr Met Gln Arg 
305                 310                 315                 320 


Glu Leu Thr Lys Ser Ser Arg Asp Met Val Glu Cys Ser Phe Asp Phe 
                325                 330                 335     


Cys Arg Lys Lys Asn Arg Phe Lys Ile Ser Leu Val Lys Pro Thr Ala 
            340                 345                 350         


Pro Leu Ala Val Val Asp Val Ser Ser Ser Ser His Pro Gly Lys Val 
        355                 360                 365             


Thr Ser Arg Ser Pro Leu Asp Gln Thr Val Leu Asn Glu Met Asn Asp 
    370                 375                 380                 


Glu Glu Arg Gly Arg Glu Arg Ser Gly Ala Gly Tyr Ala Gly Ser Arg 
385                 390                 395                 400 


Phe Val Arg Pro Asp Phe Glu Leu Ser Val Ile Asn Ser Gly Lys Ser 
                405                 410                 415     


Ile Leu Ile Lys Ser Lys Asn Phe Arg Ser Asn Leu Leu 
            420                 425                 


<210>  9
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mosopn3 mutant without the last 99 aa

<400>  9

Met Tyr Asp Ala Pro Asn Asp Val Ala Ser Ser Val Ala Asp Tyr Glu 
1               5                   10                  15      


Asp Leu Met Ala Pro Trp Ala Tyr Asn Ala Ala Ala Ile Thr Leu Phe 
            20                  25                  30          


Phe Ile Gly Phe Phe Gly Phe Phe Leu Asn Leu Phe Val Ile Ala Leu 
        35                  40                  45              


Met Ser Lys Asp Met Gln Leu Trp Thr Pro Met Asn Ile Ile Leu Phe 
    50                  55                  60                  


Asn Leu Val Cys Ser Asp Phe Ser Val Ser Ile Ile Gly Asn Pro Leu 
65                  70                  75                  80  


Thr Leu Thr Ser Ala Ile Ser His Arg Trp Ile Phe Gly Arg Thr Leu 
                85                  90                  95      


Cys Val Ala Tyr Gly Phe Phe Met Ser Leu Leu Gly Ile Thr Ser Ile 
            100                 105                 110         


Thr Thr Leu Thr Val Leu Ser Tyr Glu Arg Tyr Cys Leu Ile Ser Arg 
        115                 120                 125             


Pro Phe Ser Ser Arg Asn Leu Ser Arg Lys Gly Ala Phe Leu Ala Ile 
    130                 135                 140                 


Phe Phe Ile Trp Gly Tyr Ser Phe Ala Leu Thr Ser Pro Pro Leu Phe 
145                 150                 155                 160 


Gly Trp Gly Ala Tyr Val Gln Glu Ala Ala Asn Ile Ser Cys Ser Val 
                165                 170                 175     


Asn Trp Glu Ser Gln Thr Lys Asn Ala Thr Thr Tyr Ile Ile Phe Leu 
            180                 185                 190         


Phe Val Phe Gly Leu Val Val Pro Leu Ile Val Ile Val Tyr Ser Tyr 
        195                 200                 205             


Thr Asn Ile Ile Val Tyr Met Arg Arg Asn Ser Ala Arg Val Gly Arg 
    210                 215                 220                 


Ile Asn Arg Ala Glu Gln Arg Val Thr Ser Met Val Ala Val Met Ile 
225                 230                 235                 240 


Val Ala Phe Met Val Ala Trp Thr Pro Tyr Ala Ile Phe Ala Leu Ile 
                245                 250                 255     


Glu Gln Phe Gly Pro Pro Glu Leu Ile Gly Pro Gly Leu Ala Val Leu 
            260                 265                 270         


Pro Ala Leu Ile Ala Lys Ser Ser Ile Cys Tyr Asn Pro Ile Ile Tyr 
        275                 280                 285             


Val Gly Met Asn Thr Gln Phe Arg Ala Ala Phe Thr Arg Val Arg Asn 
    290                 295                 300                 


Lys Gly Gly Val Pro Thr Ala Asp Gln Asn Thr Thr Thr Met Gln Arg 
305                 310                 315                 320 


Glu Leu Thr Lys Ser Ser Arg Asp Met Val 
                325                 330 


<210>  10
<211>  288
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PufTMT amino acid sequence

<400>  10

Met Ser Arg Thr Gly His Thr Val Val Ala Val Met Leu Gly Thr Ile 
1               5                   10                  15      


Leu Leu Ala Gly Val Phe Gly Asn Ser Val Val Phe Leu Val Phe Val 
            20                  25                  30          


Lys Tyr Arg Ser Leu Arg Thr Pro Ile Asn Leu Ile Leu Leu Asn Ile 
        35                  40                  45              


Ser Leu Ser Asp Ile Leu Val Cys Val Phe Gly Thr Pro Leu Ser Phe 
    50                  55                  60                  


Ala Ala Ser Leu Lys Gly Arg Trp Leu Leu Gly Glu Arg Gly Cys Glu 
65                  70                  75                  80  


Trp Tyr Gly Phe Ala Asn Ser Leu Phe Gly Ile Val Ser Leu Val Ser 
                85                  90                  95      


Leu Ser Val Leu Ser Tyr Glu Arg Tyr Thr Val Val Leu Gln Pro Thr 
            100                 105                 110         


Gln Val Asp Val Ser Tyr Phe Arg Lys Ala Trp Phe Cys Val Gly Gly 
        115                 120                 125             


Ser Trp Leu Tyr Ala Leu Phe Trp Thr Leu Pro Pro Leu Leu Gly Trp 
    130                 135                 140                 


Ser Arg Tyr Gly Pro Glu Gly Pro Gly Thr Met Cys Ser Val Gln Trp 
145                 150                 155                 160 


His Leu Arg Ser Pro Ala Asn Ile Ser Tyr Val Leu Cys Leu Phe Ile 
                165                 170                 175     


Phe Cys Leu Leu Leu Pro Leu Val Val Met Val Tyr Ser Tyr Gly Arg 
            180                 185                 190         


Ile Trp Val Ala Val Arg Arg Gln His Cys Ala Gln Ser His Leu Glu 
        195                 200                 205             


Ala Gly Arg Ile Asn Leu Leu Thr Ala Gln Arg Arg Glu Gln His Ile 
    210                 215                 220                 


Leu Trp Met Val Leu Ser Met Val Ser Cys Tyr Met Leu Cys Trp Met 
225                 230                 235                 240 


Pro Tyr Gly Ile Ile Ala Leu Val Ala Thr Leu Gly Arg Leu Gly Pro 
                245                 250                 255     


Ile Ser Pro Ala Val Ser Val Val Pro Ser Ile Leu Ala Lys Phe Ser 
            260                 265                 270         


Thr Val Val Asn Pro Val Ile Tyr Met Phe Phe Asn Asn Gln Val Arg 
        275                 280                 285             


<210>  11
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ER EXPORT SIGNAL


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Phe Xaa Tyr Glu Asn Glu 
1               5       


<210>  12
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ER EXPORT SIGNAL


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Val Xaa Xaa Ser Leu 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ER EXPORT SIGNAL

<400>  13

Val Lys Glu Ser Leu 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ER EXPORT SIGNAL

<400>  14

Val Leu Gly Ser Leu 
1               5   


<210>  15
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ER EXPORT SIGNAL

<400>  15

Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser Lys 
1               5                   10                  15      


<210>  16
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MEMBRANE TRAFFICKING SIGNAL

<400>  16

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser 
            20                  25      


<210>  17
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MEMBRANE TRAFFICKING SIGNAL

<400>  17

Ala Gly His Ser Asn Ser Met Ala Leu Phe Ser Phe Ser Leu Leu Trp 
1               5                   10                  15      


Leu Cys Ser Gly Val Leu Gly Thr Glu Phe 
            20                  25      


<210>  18
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MEMBRANE TRAFFICKING SIGNAL

<400>  18

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Gly 
            20              


<210>  19
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MEMBRANE TRAFFICKING SIGNAL

<400>  19

Met Arg Gly Thr Pro Leu Leu Leu Val Val Ser Leu Phe Ser Leu Leu 
1               5                   10                  15      


Gln Asp 
        


<210>  20
<211>  864
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized nucleic acid sequence of the MosOpn3

<400>  20
atgagcagga ccggccacac cgtggtggcc gtgatgctgg gcaccatcct gctggccggc       60

gtgttcggca acagcgtggt gttcctggtg ttcgtgaagt acaggagcct gaggaccccc      120

atcaacctga tcctgctgaa catcagcctg agcgacatcc tggtgtgcgt gttcggcacc      180

cccctgagct tcgccgccag cctgaagggc aggtggctgc tgggcgagag gggctgcgag      240

tggtacggct tcgccaacag cctgttcggc atcgtgagcc tggtgagcct gagcgtgctg      300

agctacgaga ggtacaccgt ggtgctgcag cccacccagg tggacgtgag ctacttcagg      360

aaggcctggt tctgcgtggg cggcagctgg ctgtacgccc tgttctggac cctgcctcct      420

ctgctgggct ggagcaggta cggccccgag ggccctggca ccatgtgcag cgtgcagtgg      480

cacctgagga gccccgccaa catcagctac gtgctgtgcc tgttcatctt ctgcctgctg      540

ctgcccctgg tggtgatggt gtacagctac ggcaggatct gggtggccgt gaggaggcag      600

cactgcgccc agagccacct ggaggccggc aggatcaacc tgctgaccgc ccagaggagg      660

gagcagcaca tcctgtggat ggtgctgagc atggtgagct gctacatgct gtgctggatg      720

ccctacggca tcatcgccct ggtggccacc ctgggcaggc tgggccccat cagccccgcc      780

gtgagcgtgg tgcccagcat cctggccaag ttcagcaccg tggtgaaccc cgtgatctac      840

atgttcttca acaaccaggt gagg                                             864


<210>  21
<211>  990
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Alternative Codon optimized nucleic acid sequence of the MosOpn3

<400>  21
atgtacgacg cccccaacga cgtggccagc agcgtggccg actacgagga cctgatggcc       60

ccctgggcct acaacgccgc cgccatcacc ctgttcttca tcggcttctt cggcttcttc      120

ctgaacctgt tcgtgatcgc cctgatgagc aaggacatgc agctgtggac ccccatgaac      180

atcatcctgt tcaacctggt gtgcagcgac ttcagcgtga gcatcatcgg caaccccctg      240

accctgacca gcgccatcag ccaccgctgg atcttcggcc gcaccctgtg cgtggcctac      300

ggcttcttca tgagcctgct gggcatcacc agcatcacca ccctgaccgt gctgagctac      360

gagcgctact gcctgatcag ccgccccttc agcagccgca acctgagccg caagggcgcc      420

ttcctggcca tcttcttcat ctggggctac agcttcgccc tgaccagccc ccccctgttc      480

ggctggggcg cctacgtgca ggaggccgcc aacatcagct gcagcgtgaa ctgggagagc      540

cagaccaaga acgccaccac ctacatcatc ttcctgttcg tgttcggcct ggtggtgccc      600

ctgatcgtga tcgtgtacag ctacaccaac atcatcgtgt acatgcgccg caacagcgcc      660

cgcgtgggcc gcatcaaccg cgccgagcag cgcgtgacca gcatggtggc cgtgatgatc      720

gtggccttca tggtggcctg gaccccctac gccatcttcg ccctgatcga gcagttcggc      780

ccccccgagc tgatcggccc cggcctggcc gtgctgcccg ccctgatcgc caagagcagc      840

atctgctaca accccatcat ctacgtgggc atgaacaccc agttccgcgc cgccttcacc      900

cgcgtgcgca acaagggcgg cgtgcccacc gccgaccaga acaccaccac catgcagcgc      960

gagctgacca agagcagccg cgacatggtg                                       990


<210>  22
<211>  864
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized nucleic acid sequence of the PufTMT

<400>  22
atgagcagga ccggccacac cgtggtggcc gtgatgctgg gcaccatcct gctggccggc       60

gtgttcggca acagcgtggt gttcctggtg ttcgtgaagt acaggagcct gaggaccccc      120

atcaacctga tcctgctgaa catcagcctg agcgacatcc tggtgtgcgt gttcggcacc      180

cccctgagct tcgccgccag cctgaagggc aggtggctgc tgggcgagag gggctgcgag      240

tggtacggct tcgccaacag cctgttcggc atcgtgagcc tggtgagcct gagcgtgctg      300

agctacgaga ggtacaccgt ggtgctgcag cccacccagg tggacgtgag ctacttcagg      360

aaggcctggt tctgcgtggg cggcagctgg ctgtacgccc tgttctggac cctgcctcct      420

ctgctgggct ggagcaggta cggccccgag ggccctggca ccatgtgcag cgtgcagtgg      480

cacctgagga gccccgccaa catcagctac gtgctgtgcc tgttcatctt ctgcctgctg      540

ctgcccctgg tggtgatggt gtacagctac ggcaggatct gggtggccgt gaggaggcag      600

cactgcgccc agagccacct ggaggccggc aggatcaacc tgctgaccgc ccagaggagg      660

gagcagcaca tcctgtggat ggtgctgagc atggtgagct gctacatgct gtgctggatg      720

ccctacggca tcatcgccct ggtggccacc ctgggcaggc tgggccccat cagccccgcc      780

gtgagcgtgg tgcccagcat cctggccaag ttcagcaccg tggtgaaccc cgtgatctac      840

atgttcttca acaaccaggt gagg                                             864


<210>  23
<211>  864
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Alternative Codon optimized nucleic acid sequence of the PufTMT

<400>  23
atgagccgca ccggccacac cgtggtggcc gtgatgctgg gcaccatcct gctggccggc       60

gtgttcggca acagcgtggt gttcctggtg ttcgtgaagt accgcagcct gcgcaccccc      120

atcaacctga tcctgctgaa catcagcctg agcgacatcc tggtgtgcgt gttcggcacc      180

cccctgagct tcgccgccag cctgaagggc cgctggctgc tgggcgagcg cggctgcgag      240

tggtacggct tcgccaacag cctgttcggc atcgtgagcc tggtgagcct gagcgtgctg      300

agctacgagc gctacaccgt ggtgctgcag cccacccagg tggacgtgag ctacttccgc      360

aaggcctggt tctgcgtggg cggcagctgg ctgtacgccc tgttctggac cctgcccccc      420

ctgctgggct ggagccgcta cggccccgag ggccccggca ccatgtgcag cgtgcagtgg      480

cacctgcgca gccccgccaa catcagctac gtgctgtgcc tgttcatctt ctgcctgctg      540

ctgcccctgg tggtgatggt gtacagctac ggccgcatct gggtggccgt gcgccgccag      600

cactgcgccc agagccacct ggaggccggc cgcatcaacc tgctgaccgc ccagcgccgc      660

gagcagcaca tcctgtggat ggtgctgagc atggtgagct gctacatgct gtgctggatg      720

ccctacggca tcatcgccct ggtggccacc ctgggccgcc tgggccccat cagccccgcc      780

gtgagcgtgg tgcccagcat cctggccaag ttcagcaccg tggtgaaccc cgtgatctac      840

atgttcttca acaaccaggt gcgc                                             864


<210>  24
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  repetetive amino acid sequence motif

<400>  24

Glu Ala Ala Ala Lys 
1               5   


<210>  25
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PdCO2 aa sequence

<400>  25

Met Asp Gly Glu Asn Leu Thr Ile Pro Asn Pro Val Thr Glu Leu Met 
1               5                   10                  15      


Asp Thr Pro Ile Asn Ser Thr Tyr Phe Gln Asn Leu Asn Ala Glu Thr 
            20                  25                  30          


Asp Gly Gly Asn His Tyr Ile Tyr Asn Ala Phe Thr Ala Thr Asp Tyr 
        35                  40                  45              


Asn Ile Cys Ala Ala Tyr Leu Phe Phe Ile Ala Cys Leu Gly Val Ser 
    50                  55                  60                  


Leu Asn Val Leu Val Leu Val Leu Phe Ile Lys Asp Arg Lys Leu Arg 
65                  70                  75                  80  


Ser Pro Asn Asn Phe Leu Tyr Val Ser Leu Ala Leu Gly Asp Leu Leu 
                85                  90                  95      


Val Ala Val Phe Gly Thr Ala Phe Lys Phe Ile Ile Thr Ala Arg Lys 
            100                 105                 110         


Thr Leu Leu Arg Glu Glu Asp Gly Phe Cys Lys Trp Tyr Gly Phe Ile 
        115                 120                 125             


Thr Tyr Leu Gly Gly Leu Ala Ala Leu Met Thr Leu Ser Val Ile Ala 
    130                 135                 140                 


Phe Val Arg Cys Leu Ala Val Leu Arg Leu Gly Ser Phe Thr Gly Leu 
145                 150                 155                 160 


Thr Thr Arg Met Gly Val Ala Ala Met Ala Phe Ile Trp Ile Tyr Ser 
                165                 170                 175     


Leu Ala Phe Thr Leu Ala Pro Leu Leu Gly Trp Asn His Tyr Ile Pro 
            180                 185                 190         


Glu Gly Leu Ala Thr Trp Cys Ser Ile Asp Trp Leu Ser Asp Glu Thr 
        195                 200                 205             


Ser Asp Lys Ser Tyr Val Phe Ala Ile Phe Ile Phe Cys Phe Leu Val 
    210                 215                 220                 


Pro Val Leu Ile Ile Val Val Ser Tyr Gly Leu Ile Tyr Asp Lys Val 
225                 230                 235                 240 


Arg Lys Val Ala Lys Thr Gly Gly Ser Val Ala Lys Ala Glu Arg Glu 
                245                 250                 255     


Val Leu Arg Met Thr Leu Leu Met Val Ser Leu Phe Met Leu Ala Trp 
            260                 265                 270         


Ser Pro Tyr Ala Val Ile Cys Met Leu Ala Ser Phe Gly Pro Lys Asp 
        275                 280                 285             


Leu Leu His Pro Val Ala Thr Val Ile Pro Ala Met Phe Ala Lys Ser 
    290                 295                 300                 


Ser Thr Met Tyr Asn Pro Leu Ile Tyr Val Phe Met Asn Lys Gln Phe 
305                 310                 315                 320 


Arg Arg Ser Leu Lys Val Leu Leu Gly Met Gly Val Glu Asp Leu Asn 
                325                 330                 335     


Ser Glu Ser Glu Arg Ala Thr Gly Gly Thr Ala Thr Asn Gln Val Ala 
            340                 345                 350         


Ala Thr 
        


<210>  26
<211>  1062
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PdCO2 na sequence

<400>  26
atggacgggg agaacttgac gattccaaat cctgtcaccg agttgatgga taccccaatc       60

aacagcacgt atttccaaaa ccttaatgcg gaaacggacg gcggaaatca ttacatctac      120

aatgccttca cagccaccga ttacaacatt tgtgcagctt accttttctt cattgcttgt      180

ctgggagtca gtctcaacgt tttggtgttg gtcctcttta tcaaagacag aaagttgagg      240

agccccaata acttcctgta tgtaagtctc gctctcgggg atctgttggt tgcagttttc      300

ggcaccgcat ttaagttcat tattacagct cgcaaaaccc tgttgcgaga agaagacggt      360

ttctgcaaat ggtacggctt cataacatac ctcggcgggc tcgcggcact gatgaccctg      420

agcgttattg cttttgttcg ttgtctggcc gtgctgcgtc tcggctcctt cacaggtttg      480

acaacgcgga tgggcgtggc ggcgatggct ttcatttgga tctactccct ggcattcaca      540

ctcgcgcctc tccttgggtg gaatcactac ataccggaag gtttggccac ttggtgtagt      600

atcgactggc tttccgatga aacatccgat aagtcctacg tgtttgctat tttcatcttc      660

tgctttcttg tccctgttct cattatcgtc gtgtcatacg ggctgatcta cgataaggtt      720

cggaaggtag cgaaaacagg cggttctgtt gccaaagcag aacgcgaagt actgcgcatg      780

acgctgctga tggttagcct gttcatgctt gcctggagtc cctacgctgt tatctgcatg      840

ctcgctagct tcggccctaa agacctgctc catccagtgg ccacagtgat tcctgccatg      900

tttgcaaagt cttctacgat gtataaccct cttatctatg tgttcatgaa caaacaattc      960

aggcggagcc ttaaagttct tctcggaatg ggagtagagg acctgaactc cgagagtgag     1020

agagcaactg gtggtacagc cacgaatcaa gtcgccgcga cg                        1062


<210>  27
<211>  631
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PdCO2-mScarlet open reading frame AA sequence

<400>  27

Met Asp Gly Glu Asn Leu Thr Ile Pro Asn Pro Val Thr Glu Leu Met 
1               5                   10                  15      


Asp Thr Pro Ile Asn Ser Thr Tyr Phe Gln Asn Leu Asn Ala Glu Thr 
            20                  25                  30          


Asp Gly Gly Asn His Tyr Ile Tyr Asn Ala Phe Thr Ala Thr Asp Tyr 
        35                  40                  45              


Asn Ile Cys Ala Ala Tyr Leu Phe Phe Ile Ala Cys Leu Gly Val Ser 
    50                  55                  60                  


Leu Asn Val Leu Val Leu Val Leu Phe Ile Lys Asp Arg Lys Leu Arg 
65                  70                  75                  80  


Ser Pro Asn Asn Phe Leu Tyr Val Ser Leu Ala Leu Gly Asp Leu Leu 
                85                  90                  95      


Val Ala Val Phe Gly Thr Ala Phe Lys Phe Ile Ile Thr Ala Arg Lys 
            100                 105                 110         


Thr Leu Leu Arg Glu Glu Asp Gly Phe Cys Lys Trp Tyr Gly Phe Ile 
        115                 120                 125             


Thr Tyr Leu Gly Gly Leu Ala Ala Leu Met Thr Leu Ser Val Ile Ala 
    130                 135                 140                 


Phe Val Arg Cys Leu Ala Val Leu Arg Leu Gly Ser Phe Thr Gly Leu 
145                 150                 155                 160 


Thr Thr Arg Met Gly Val Ala Ala Met Ala Phe Ile Trp Ile Tyr Ser 
                165                 170                 175     


Leu Ala Phe Thr Leu Ala Pro Leu Leu Gly Trp Asn His Tyr Ile Pro 
            180                 185                 190         


Glu Gly Leu Ala Thr Trp Cys Ser Ile Asp Trp Leu Ser Asp Glu Thr 
        195                 200                 205             


Ser Asp Lys Ser Tyr Val Phe Ala Ile Phe Ile Phe Cys Phe Leu Val 
    210                 215                 220                 


Pro Val Leu Ile Ile Val Val Ser Tyr Gly Leu Ile Tyr Asp Lys Val 
225                 230                 235                 240 


Arg Lys Val Ala Lys Thr Gly Gly Ser Val Ala Lys Ala Glu Arg Glu 
                245                 250                 255     


Val Leu Arg Met Thr Leu Leu Met Val Ser Leu Phe Met Leu Ala Trp 
            260                 265                 270         


Ser Pro Tyr Ala Val Ile Cys Met Leu Ala Ser Phe Gly Pro Lys Asp 
        275                 280                 285             


Leu Leu His Pro Val Ala Thr Val Ile Pro Ala Met Phe Ala Lys Ser 
    290                 295                 300                 


Ser Thr Met Tyr Asn Pro Leu Ile Tyr Val Phe Met Asn Lys Gln Phe 
305                 310                 315                 320 


Arg Arg Ser Leu Lys Val Leu Leu Gly Met Gly Val Glu Asp Leu Asn 
                325                 330                 335     


Ser Glu Ser Glu Arg Ala Thr Gly Gly Thr Ala Thr Asn Gln Val Ala 
            340                 345                 350         


Ala Thr Thr Glu Thr Ser Gln Val Ala Pro Ala Pro Arg Ala Arg Asp 
        355                 360                 365             


Pro Thr Gly Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu 
    370                 375                 380                 


Asp Gln Ile Asp Ile Asn Val Val Met Val Ser Lys Gly Glu Ala Val 
385                 390                 395                 400 


Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Met Asn 
                405                 410                 415     


Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu 
            420                 425                 430         


Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro 
        435                 440                 445             


Phe Ser Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Arg Ala 
    450                 455                 460                 


Phe Thr Lys His Pro Ala Asp Ile Pro Asp Tyr Tyr Lys Gln Ser Phe 
465                 470                 475                 480 


Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly 
                485                 490                 495     


Ala Val Thr Val Thr Gln Asp Thr Ser Leu Glu Asp Gly Thr Leu Ile 
            500                 505                 510         


Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Pro Asp Gly Pro Val 
        515                 520                 525             


Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr 
    530                 535                 540                 


Pro Glu Asp Gly Val Leu Lys Gly Asp Ile Lys Met Ala Leu Arg Leu 
545                 550                 555                 560 


Lys Asp Gly Gly Arg Tyr Leu Ala Asp Phe Lys Thr Thr Tyr Lys Ala 
                565                 570                 575     


Lys Lys Pro Val Gln Met Pro Gly Ala Tyr Asn Val Asp Arg Lys Leu 
            580                 585                 590         


Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Val Val Glu Gln Tyr Glu 
        595                 600                 605             


Arg Ser Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
    610                 615                 620                 


Phe Cys Tyr Glu Asn Glu Val 
625                 630     


<210>  28
<211>  1900
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PdCO2-mScarlet open reading frame NA sequence

<400>  28
atggacgggg agaacttgac gattccaaat cctgtcaccg agttgatgga taccccaatc       60

aacagcacgt atttccaaaa ccttaatgcg gaaacggacg gcggaaatca ttacatctac      120

aatgccttca cagccaccga ttacaacatt tgtgcagctt accttttctt cattgcttgt      180

ctgggagtca gtctcaacgt tttggtgttg gtcctcttta tcaaagacag aaagttgagg      240

agccccaata acttcctgta tgtaagtctc gctctcgggg atctgttggt tgcagttttc      300

ggcaccgcat ttaagttcat tattacagct cgcaaaaccc tgttgcgaga agaagacggt      360

ttctgcaaat ggtacggctt cataacatac ctcggcgggc tcgcggcact gatgaccctg      420

agcgttattg cttttgttcg ttgtctggcc gtgctgcgtc tcggctcctt cacaggtttg      480

acaacgcgga tgggcgtggc ggcgatggct ttcatttgga tctactccct ggcattcaca      540

ctcgcgcctc tccttgggtg gaatcactac ataccggaag gtttggccac ttggtgtagt      600

atcgactggc tttccgatga aacatccgat aagtcctacg tgtttgctat tttcatcttc      660

tgctttcttg tccctgttct cattatcgtc gtgtcatacg ggctgatcta cgataaggtt      720

cggaaggtag cgaaaacagg cggttctgtt gccaaagcag aacgcgaagt actgcgcatg      780

acgctgctga tggttagcct gttcatgctt gcctggagtc cctacgctgt tatctgcatg      840

ctcgctagct tcggccctaa agacctgctc catccagtgg ccacagtgat tcctgccatg      900

tttgcaaagt cttctacgat gtataaccct cttatctatg tgttcatgaa caaacaattc      960

aggcggagcc ttaaagttct tctcggaatg ggagtagagg acctgaactc cgagagtgag     1020

agagcaactg gtggtacagc cacgaatcaa gtcgccgcga cgaccgagac ttcccaggtt     1080

gctcctgctc cgcgagcccg agatccaacc ggtaagagca ggatcaccag cgagggcgag     1140

tacatccccc tggaccagat cgacatcaac gtggtgatgg tgagcaaggg cgaggcagtg     1200

atcaaggagt tcatgcggtt caaggtgcac atggagggct ccatgaacgg ccacgagttc     1260

gagatcgagg gcgagggcga gggccgcccc tacgagggca cccagaccgc caagctgaag     1320

gtgaccaagg gtggccccct gcccttctcc tgggacatcc tgtcccctca gttcatgtac     1380

ggctccaggg ccttcaccaa gcaccccgcc gacatccccg actactataa gcagtccttc     1440

cccgagggct tcaagtggga gcgcgtgatg aacttcgagg acggcggcgc cgtgaccgtg     1500

acccaggaca cctccctgga ggacggcacc ctgatctaca aggtgaagct ccgcggcacc     1560

aacttccctc ctgacggccc cgtaatgcag aagaagacaa tgggctggga agcgtccacc     1620

gagcggttgt accccgagga cggcgtgctg aagggcgaca ttaagatggc cctgcgcctg     1680

aaggacggcg gacgctacct ggcggacttc aagaccacct acaaggccaa gaagcccgtg     1740

cagatgcccg gcgcctacaa cgtcgaccgc aagttggaca tcacctccca caacgaggac     1800

tacaccgtgg tggaacagta cgaacgctcc gagggccgcc actccaccgg cggcatggac     1860

gagctgtaca agttctgcta cgagaacgag gtgtaactag                           1900


<210>  29
<211>  343
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LcPP aa sequence

<400>  29

Met Glu Asn Leu Thr Ser Leu Asp Leu Leu Pro Asn Gly Glu Val Pro 
1               5                   10                  15      


Leu Met Pro Arg Tyr Gly Phe Thr Ile Leu Ala Val Ile Met Ala Val 
            20                  25                  30          


Phe Thr Ile Ala Ser Leu Val Leu Asn Ser Thr Val Val Ile Val Thr 
        35                  40                  45              


Leu Arg His Arg Gln Leu Arg His Pro Leu Asn Phe Ser Leu Val Asn 
    50                  55                  60                  


Leu Ala Val Ala Asp Leu Gly Val Thr Val Phe Gly Ala Ser Leu Val 
65                  70                  75                  80  


Val Glu Thr Asn Ala Val Gly Tyr Phe Asn Leu Gly Arg Val Gly Cys 
                85                  90                  95      


Val Ile Glu Gly Phe Ala Val Ala Phe Phe Gly Ile Ala Ala Leu Cys 
            100                 105                 110         


Thr Ile Ala Val Ile Ala Val Asp Arg Phe Val Val Val Cys Lys Pro 
        115                 120                 125             


Leu Gly Thr Leu Met Phe Thr Arg Arg His Ala Leu Leu Gly Ile Ala 
    130                 135                 140                 


Trp Ala Trp Leu Trp Ser Phe Val Trp Asn Thr Pro Pro Leu Phe Gly 
145                 150                 155                 160 


Trp Gly Ser Tyr Glu Leu Glu Gly Val Arg Thr Ser Cys Ala Pro Asp 
                165                 170                 175     


Trp Tyr Ser Arg Asp Pro Ala Asn Val Ser Tyr Ile Thr Ser Tyr Phe 
            180                 185                 190         


Ala Phe Cys Phe Ala Ile Pro Phe Leu Val Ile Val Val Ala Tyr Gly 
        195                 200                 205             


Arg Leu Met Trp Thr Leu His Gln Val Ala Lys Leu Gly Met Gly Glu 
    210                 215                 220                 


Ser Gly Ser Thr Ala Lys Ala Glu Ala Gln Val Ser Arg Met Val Val 
225                 230                 235                 240 


Val Met Val Val Ala Phe Leu Val Cys Trp Leu Pro Tyr Ala Leu Phe 
                245                 250                 255     


Ala Met Ile Val Val Thr Lys Pro Asp Val Tyr Ile Asp Pro Val Ile 
            260                 265                 270         


Ala Thr Leu Pro Met Tyr Leu Thr Lys Thr Ser Thr Val Tyr Asn Pro 
        275                 280                 285             


Ile Ile Tyr Ile Phe Met Asn Arg Gln Phe Arg Asp Cys Ala Val Pro 
    290                 295                 300                 


Phe Leu Leu Cys Gly Arg Asn Pro Trp Ala Glu Pro Ser Ser Glu Ser 
305                 310                 315                 320 


Ala Thr Ala Ala Ser Thr Ser Ala Thr Ser Val Thr Leu Ala Ser Ala 
                325                 330                 335     


Pro Gly Gln Val Ser Pro Ser 
            340             


<210>  30
<211>  1029
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LcPP na sequence

<400>  30
atggaaaatc tgacttccct ggatctgctg cccaacggag aggtcccact gatgccccgg       60

tacggcttta ctattctggc tgtgattatg gccgtgttca ccatcgcaag tctggtcctg      120

aactcaactg tggtcattgt gaccctgcga caccgacagc tgaggcatcc tctgaacttt      180

tccctggtga atctggctgt cgcagacctg ggcgtgacag tcttcggagc ttctctggtg      240

gtcgagacta acgcagtggg gtactttaat ctgggacgcg tggggtgcgt catcgaaggg      300

ttcgccgtgg ctttctttgg cattgccgct ctgtgcacca tcgctgtgat tgcagtcgat      360

cgatttgtgg tggtgtgcaa gcccctggga accctgatgt tcacaaggag acacgcactg      420

ctgggaatcg catgggcatg gctgtggagc ttcgtgtgga acacaccccc tctgttcggc      480

tggggaagct acgagctgga aggagtgaga actagctgcg ctcctgactg gtattcccgg      540

gaccccgcca acgtgagcta catcacatct tatttcgcat tttgtttcgc catccccttc      600

ctggtcatcg tcgtggctta cggccggctg atgtggactc tgcatcaggt ggccaagctg      660

gggatgggcg agtctggaag taccgctaaa gcagaagccc aggtgagtcg catggtcgtg      720

gtcatggtgg tcgcctttct ggtctgttgg ctgccctatg ccctgttcgc tatgatcgtg      780

gtcaccaagc ctgacgtgta catcgatcca gtcattgcca cactgcccat gtatctgacc      840

aaaacaagca ccgtgtacaa ccccatcatc tacatcttca tgaatcgaca gttcagggac      900

tgcgccgtgc ctttcctgct gtgcggcagg aatccctggg cagagcccag ctccgaatct      960

gccacagcag cctcaaccag cgccacaagt gtgactctgg cttcagcacc aggacaggtc     1020

tccccatcc                                                             1029


<210>  31
<211>  620
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LcPP -mScarlet open reading frame AA sequence

<400>  31

Met Glu Asn Leu Thr Ser Leu Asp Leu Leu Pro Asn Gly Glu Val Pro 
1               5                   10                  15      


Leu Met Pro Arg Tyr Gly Phe Thr Ile Leu Ala Val Ile Met Ala Val 
            20                  25                  30          


Phe Thr Ile Ala Ser Leu Val Leu Asn Ser Thr Val Val Ile Val Thr 
        35                  40                  45              


Leu Arg His Arg Gln Leu Arg His Pro Leu Asn Phe Ser Leu Val Asn 
    50                  55                  60                  


Leu Ala Val Ala Asp Leu Gly Val Thr Val Phe Gly Ala Ser Leu Val 
65                  70                  75                  80  


Val Glu Thr Asn Ala Val Gly Tyr Phe Asn Leu Gly Arg Val Gly Cys 
                85                  90                  95      


Val Ile Glu Gly Phe Ala Val Ala Phe Phe Gly Ile Ala Ala Leu Cys 
            100                 105                 110         


Thr Ile Ala Val Ile Ala Val Asp Arg Phe Val Val Val Cys Lys Pro 
        115                 120                 125             


Leu Gly Thr Leu Met Phe Thr Arg Arg His Ala Leu Leu Gly Ile Ala 
    130                 135                 140                 


Trp Ala Trp Leu Trp Ser Phe Val Trp Asn Thr Pro Pro Leu Phe Gly 
145                 150                 155                 160 


Trp Gly Ser Tyr Glu Leu Glu Gly Val Arg Thr Ser Cys Ala Pro Asp 
                165                 170                 175     


Trp Tyr Ser Arg Asp Pro Ala Asn Val Ser Tyr Ile Thr Ser Tyr Phe 
            180                 185                 190         


Ala Phe Cys Phe Ala Ile Pro Phe Leu Val Ile Val Val Ala Tyr Gly 
        195                 200                 205             


Arg Leu Met Trp Thr Leu His Gln Val Ala Lys Leu Gly Met Gly Glu 
    210                 215                 220                 


Ser Gly Ser Thr Ala Lys Ala Glu Ala Gln Val Ser Arg Met Val Val 
225                 230                 235                 240 


Val Met Val Val Ala Phe Leu Val Cys Trp Leu Pro Tyr Ala Leu Phe 
                245                 250                 255     


Ala Met Ile Val Val Thr Lys Pro Asp Val Tyr Ile Asp Pro Val Ile 
            260                 265                 270         


Ala Thr Leu Pro Met Tyr Leu Thr Lys Thr Ser Thr Val Tyr Asn Pro 
        275                 280                 285             


Ile Ile Tyr Ile Phe Met Asn Arg Gln Phe Arg Asp Cys Ala Val Pro 
    290                 295                 300                 


Phe Leu Leu Cys Gly Arg Asn Pro Trp Ala Glu Pro Ser Ser Glu Ser 
305                 310                 315                 320 


Ala Thr Ala Ala Ser Thr Ser Ala Thr Ser Val Thr Leu Ala Ser Ala 
                325                 330                 335     


Pro Gly Gln Val Ser Pro Ser Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345                 350         


Pro Arg Ala Arg Asp Pro Thr Gly Lys Ser Arg Ile Thr Ser Glu Gly 
        355                 360                 365             


Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Val Met Val Ser 
    370                 375                 380                 


Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys Val His Met 
385                 390                 395                 400 


Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu 
                405                 410                 415     


Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys 
            420                 425                 430         


Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro Gln Phe Met 
        435                 440                 445             


Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile Pro Asp Tyr 
    450                 455                 460                 


Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn 
465                 470                 475                 480 


Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr Ser Leu Glu 
                485                 490                 495     


Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro 
            500                 505                 510         


Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser 
        515                 520                 525             


Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly Asp Ile Lys 
    530                 535                 540                 


Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala Asp Phe Lys 
545                 550                 555                 560 


Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly Ala Tyr Asn 
                565                 570                 575     


Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Val 
            580                 585                 590         


Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr Gly Gly Met 
        595                 600                 605             


Asp Glu Leu Tyr Lys Phe Cys Tyr Glu Asn Glu Val 
    610                 615                 620 


<210>  32
<211>  1863
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LcPP -mScarlet open reading frame NA sequence

<400>  32
atggaaaatc tgacttccct ggatctgctg cccaacggag aggtcccact gatgccccgg       60

tacggcttta ctattctggc tgtgattatg gccgtgttca ccatcgcaag tctggtcctg      120

aactcaactg tggtcattgt gaccctgcga caccgacagc tgaggcatcc tctgaacttt      180

tccctggtga atctggctgt cgcagacctg ggcgtgacag tcttcggagc ttctctggtg      240

gtcgagacta acgcagtggg gtactttaat ctgggacgcg tggggtgcgt catcgaaggg      300

ttcgccgtgg ctttctttgg cattgccgct ctgtgcacca tcgctgtgat tgcagtcgat      360

cgatttgtgg tggtgtgcaa gcccctggga accctgatgt tcacaaggag acacgcactg      420

ctgggaatcg catgggcatg gctgtggagc ttcgtgtgga acacaccccc tctgttcggc      480

tggggaagct acgagctgga aggagtgaga actagctgcg ctcctgactg gtattcccgg      540

gaccccgcca acgtgagcta catcacatct tatttcgcat tttgtttcgc catccccttc      600

ctggtcatcg tcgtggctta cggccggctg atgtggactc tgcatcaggt ggccaagctg      660

gggatgggcg agtctggaag taccgctaaa gcagaagccc aggtgagtcg catggtcgtg      720

gtcatggtgg tcgcctttct ggtctgttgg ctgccctatg ccctgttcgc tatgatcgtg      780

gtcaccaagc ctgacgtgta catcgatcca gtcattgcca cactgcccat gtatctgacc      840

aaaacaagca ccgtgtacaa ccccatcatc tacatcttca tgaatcgaca gttcagggac      900

tgcgccgtgc ctttcctgct gtgcggcagg aatccctggg cagagcccag ctccgaatct      960

gccacagcag cctcaaccag cgccacaagt gtgactctgg cttcagcacc aggacaggtc     1020

tccccatcca ccgagaccag ccaggtggct cctgctccgc gagcccgaga tccaaccggt     1080

aagagcagga tcaccagcga gggcgagtac atccccctgg accagatcga catcaacgtg     1140

gtgatggtga gcaagggcga ggcagtgatc aaggagttca tgcggttcaa ggtgcacatg     1200

gagggctcca tgaacggcca cgagttcgag atcgagggcg agggcgaggg ccgcccctac     1260

gagggcaccc agaccgccaa gctgaaggtg accaagggtg gccccctgcc cttctcctgg     1320

gacatcctgt cccctcagtt catgtacggc tccagggcct tcaccaagca ccccgccgac     1380

atccccgact actataagca gtccttcccc gagggcttca agtgggagcg cgtgatgaac     1440

ttcgaggacg gcggcgccgt gaccgtgacc caggacacct ccctggagga cggcaccctg     1500

atctacaagg tgaagctccg cggcaccaac ttccctcctg acggccccgt aatgcagaag     1560

aagacaatgg gctgggaagc gtccaccgag cggttgtacc ccgaggacgg cgtgctgaag     1620

ggcgacatta agatggccct gcgcctgaag gacggcggac gctacctggc ggacttcaag     1680

accacctaca aggccaagaa gcccgtgcag atgcccggcg cctacaacgt cgaccgcaag     1740

ttggacatca cctcccacaa cgaggactac accgtggtgg aacagtacga acgctccgag     1800

ggccgccact ccaccggcgg catggacgag ctgtacaagt tctgctacga gaacgaggtg     1860

taa                                                                   1863


<210>  33
<211>  342
<212>  PRT
<213>  Artificial sequence

<220>
<223>  medakaTMT1A aa sequence

<400>  33

Met Leu Val Ser Asn Val Ser Leu Gly Gly Cys Ala Glu Phe Asn Ser 
1               5                   10                  15      


Ala Leu Cys Ala Gly Ala Gly Glu Glu His Leu Gly Gly Gly Ser Tyr 
            20                  25                  30          


Arg Thr Thr Leu Thr Pro Thr Gly His Leu Ile Val Ala Val Cys Leu 
        35                  40                  45              


Gly Phe Ile Gly Thr Phe Gly Leu Val Asn Asn Leu Leu Val Leu Val 
    50                  55                  60                  


Leu Phe Cys Arg Tyr Lys Ile Leu Arg Ser Pro Ile Asn Leu Leu Leu 
65                  70                  75                  80  


Ile Asn Ile Ser Ile Ser Asp Leu Leu Val Cys Val Leu Gly Thr Pro 
                85                  90                  95      


Phe Ser Phe Ala Ala Ser Thr Gln Gly Arg Trp Leu Ile Gly Glu Gly 
            100                 105                 110         


Gly Cys Val Trp Tyr Gly Phe Ala Asn Ser Leu Cys Gly Ile Val Ser 
        115                 120                 125             


Leu Ile Ser Leu Ala Val Leu Ser Tyr Glu Arg Tyr Ser Thr Met Met 
    130                 135                 140                 


Thr Pro Ala Glu Ala Asp Ser Ser Asn Tyr Arg Lys Ile Ser Leu Gly 
145                 150                 155                 160 


Ile Ile Leu Ser Trp Gly Tyr Ser Leu Leu Trp Thr Leu Pro Pro Leu 
                165                 170                 175     


Phe Gly Trp Ser His Tyr Gly Pro Glu Gly Pro Gly Thr Thr Cys Ser 
            180                 185                 190         


Val Asp Trp Thr Ala Lys Thr Ala Asn Asn Ile Ser Tyr Ile Ile Cys 
        195                 200                 205             


Leu Phe Val Phe Cys Leu Ile Val Pro Phe Met Val Ile Val Phe Cys 
    210                 215                 220                 


Tyr Gly Lys Leu Leu Tyr Ala Ile Lys Gln Val Ser Gly Ile Asn Val 
225                 230                 235                 240 


Ser Val Ser Arg Lys Arg Glu Gln Arg Val Leu Phe Met Val Val Ile 
                245                 250                 255     


Met Val Ile Cys Tyr Leu Leu Cys Trp Leu Pro Tyr Gly Ile Met Ala 
            260                 265                 270         


Leu Leu Ala Thr Phe Gly Pro Pro Asp Leu Val Thr Pro Glu Ala Ser 
        275                 280                 285             


Ile Ile Pro Ser Val Leu Ala Lys Thr Ser Thr Ala Ile Asn Pro Val 
    290                 295                 300                 


Ile Tyr Val Phe Met Asn Lys Gln Phe Phe Arg Cys Phe Gln Ala Met 
305                 310                 315                 320 


Leu Arg Cys Lys Ala Pro Leu Arg Gly Ser Ser Ala Arg Ser Ser Ser 
                325                 330                 335     


Lys Val Ala Thr Lys Ala 
            340         


<210>  34
<211>  1026
<212>  DNA
<213>  Artificial sequence

<220>
<223>  medakaTMT1A na sequence

<400>  34
atgctagtca gtaatgtaag cctgggtggg tgcgccgaat tcaattccgc tctttgtgcg       60

ggcgctggag aagaacacct cggcggtggt tcatatcgga ccacgctaac cccgactggc      120

catctcattg tcgctgtgtg ccttgggttc attggcactt tcgggcttgt aaataatttg      180

cttgtcttgg tcctattctg tcgttataag attctgcgga gccctatcaa tcttctactt      240

attaatatca gtatttccga cctgctcgtt tgcgtgctgg gcaccccttt ctcctttgct      300

gctagtacac aaggcaggtg gttgattggc gagggcggat gtgtatggta cggatttgcg      360

aacagcctgt gtgggatcgt tagcctaatt tcccttgctg tcctttctta tgaacgttac      420

tctactatga tgacccccgc ggaagccgac tcaagtaatt accggaaaat aagtctcggt      480

atcatcctct cctggggcta tagtttgctc tggacgttgc cccctttgtt tggctggagt      540

cattacgggc ccgaaggacc aggaaccacc tgtagcgtcg attggaccgc caagaccgcc      600

aataacatta gctatattat ctgcctgttt gtgttctgtc ttatcgtgcc gtttatggtg      660

attgtatttt gctatggtaa actgctgtac gctattaaac aagtgagcgg aattaatgtc      720

agtgtaagta ggaaacgaga acaacgcgtg ctctttatgg tggtcattat ggtcatatgc      780

tacctgcttt gttggctccc ttacggcatt atggcccttc tcgcaacgtt tggaccccca      840

gacctcgtca ccccagaagc ctctatcata ccctcagttc tcgcgaagac tagtaccgct      900

ataaatccag ttatctatgt ctttatgaat aagcagttct tcaggtgttt ccaagcaatg      960

cttaggtgta aagctccact gcgcgggagc tcagcaaggt ccagctccaa agttgctaca     1020

aaagct                                                                1026


<210>  35
<211>  619
<212>  PRT
<213>  Artificial sequence

<220>
<223>  medakaTMT1A -mScarlet open reading frame AA sequence

<400>  35

Met Leu Val Ser Asn Val Ser Leu Gly Gly Cys Ala Glu Phe Asn Ser 
1               5                   10                  15      


Ala Leu Cys Ala Gly Ala Gly Glu Glu His Leu Gly Gly Gly Ser Tyr 
            20                  25                  30          


Arg Thr Thr Leu Thr Pro Thr Gly His Leu Ile Val Ala Val Cys Leu 
        35                  40                  45              


Gly Phe Ile Gly Thr Phe Gly Leu Val Asn Asn Leu Leu Val Leu Val 
    50                  55                  60                  


Leu Phe Cys Arg Tyr Lys Ile Leu Arg Ser Pro Ile Asn Leu Leu Leu 
65                  70                  75                  80  


Ile Asn Ile Ser Ile Ser Asp Leu Leu Val Cys Val Leu Gly Thr Pro 
                85                  90                  95      


Phe Ser Phe Ala Ala Ser Thr Gln Gly Arg Trp Leu Ile Gly Glu Gly 
            100                 105                 110         


Gly Cys Val Trp Tyr Gly Phe Ala Asn Ser Leu Cys Gly Ile Val Ser 
        115                 120                 125             


Leu Ile Ser Leu Ala Val Leu Ser Tyr Glu Arg Tyr Ser Thr Met Met 
    130                 135                 140                 


Thr Pro Ala Glu Ala Asp Ser Ser Asn Tyr Arg Lys Ile Ser Leu Gly 
145                 150                 155                 160 


Ile Ile Leu Ser Trp Gly Tyr Ser Leu Leu Trp Thr Leu Pro Pro Leu 
                165                 170                 175     


Phe Gly Trp Ser His Tyr Gly Pro Glu Gly Pro Gly Thr Thr Cys Ser 
            180                 185                 190         


Val Asp Trp Thr Ala Lys Thr Ala Asn Asn Ile Ser Tyr Ile Ile Cys 
        195                 200                 205             


Leu Phe Val Phe Cys Leu Ile Val Pro Phe Met Val Ile Val Phe Cys 
    210                 215                 220                 


Tyr Gly Lys Leu Leu Tyr Ala Ile Lys Gln Val Ser Gly Ile Asn Val 
225                 230                 235                 240 


Ser Val Ser Arg Lys Arg Glu Gln Arg Val Leu Phe Met Val Val Ile 
                245                 250                 255     


Met Val Ile Cys Tyr Leu Leu Cys Trp Leu Pro Tyr Gly Ile Met Ala 
            260                 265                 270         


Leu Leu Ala Thr Phe Gly Pro Pro Asp Leu Val Thr Pro Glu Ala Ser 
        275                 280                 285             


Ile Ile Pro Ser Val Leu Ala Lys Thr Ser Thr Ala Ile Asn Pro Val 
    290                 295                 300                 


Ile Tyr Val Phe Met Asn Lys Gln Phe Phe Arg Cys Phe Gln Ala Met 
305                 310                 315                 320 


Leu Arg Cys Lys Ala Pro Leu Arg Gly Ser Ser Ala Arg Ser Ser Ser 
                325                 330                 335     


Lys Val Ala Thr Lys Ala Thr Glu Thr Ser Gln Val Ala Pro Ala Pro 
            340                 345                 350         


Arg Ala Arg Asp Pro Thr Gly Lys Ser Arg Ile Thr Ser Glu Gly Glu 
        355                 360                 365             


Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Val Met Val Ser Lys 
    370                 375                 380                 


Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu 
385                 390                 395                 400 


Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly 
                405                 410                 415     


Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly 
            420                 425                 430         


Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr 
        435                 440                 445             


Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile Pro Asp Tyr Tyr 
    450                 455                 460                 


Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe 
465                 470                 475                 480 


Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr Ser Leu Glu Asp 
                485                 490                 495     


Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Pro 
            500                 505                 510         


Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Thr 
        515                 520                 525             


Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly Asp Ile Lys Met 
    530                 535                 540                 


Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala Asp Phe Lys Thr 
545                 550                 555                 560 


Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly Ala Tyr Asn Val 
                565                 570                 575     


Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Val Val 
            580                 585                 590         


Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr Gly Gly Met Asp 
        595                 600                 605             


Glu Leu Tyr Lys Phe Cys Tyr Glu Asn Glu Val 
    610                 615                 


<210>  36
<211>  1860
<212>  DNA
<213>  Artificial sequence

<220>
<223>  medakaTMT1A -mScarlet open reading frame NA sequence

<400>  36
atgctagtca gtaatgtaag cctgggtggg tgcgccgaat tcaattccgc tctttgtgcg       60

ggcgctggag aagaacacct cggcggtggt tcatatcgga ccacgctaac cccgactggc      120

catctcattg tcgctgtgtg ccttgggttc attggcactt tcgggcttgt aaataatttg      180

cttgtcttgg tcctattctg tcgttataag attctgcgga gccctatcaa tcttctactt      240

attaatatca gtatttccga cctgctcgtt tgcgtgctgg gcaccccttt ctcctttgct      300

gctagtacac aaggcaggtg gttgattggc gagggcggat gtgtatggta cggatttgcg      360

aacagcctgt gtgggatcgt tagcctaatt tcccttgctg tcctttctta tgaacgttac      420

tctactatga tgacccccgc ggaagccgac tcaagtaatt accggaaaat aagtctcggt      480

atcatcctct cctggggcta tagtttgctc tggacgttgc cccctttgtt tggctggagt      540

cattacgggc ccgaaggacc aggaaccacc tgtagcgtcg attggaccgc caagaccgcc      600

aataacatta gctatattat ctgcctgttt gtgttctgtc ttatcgtgcc gtttatggtg      660

attgtatttt gctatggtaa actgctgtac gctattaaac aagtgagcgg aattaatgtc      720

agtgtaagta ggaaacgaga acaacgcgtg ctctttatgg tggtcattat ggtcatatgc      780

tacctgcttt gttggctccc ttacggcatt atggcccttc tcgcaacgtt tggaccccca      840

gacctcgtca ccccagaagc ctctatcata ccctcagttc tcgcgaagac tagtaccgct      900

ataaatccag ttatctatgt ctttatgaat aagcagttct tcaggtgttt ccaagcaatg      960

cttaggtgta aagctccact gcgcgggagc tcagcaaggt ccagctccaa agttgctaca     1020

aaagctacag agacaagcca agtggcgcct gctccgcgag cccgagatcc aaccggtaag     1080

agcaggatca ccagcgaggg cgagtacatc cccctggacc agatcgacat caacgtggtg     1140

atggtgagca agggcgaggc agtgatcaag gagttcatgc ggttcaaggt gcacatggag     1200

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag     1260

ggcacccaga ccgccaagct gaaggtgacc aagggtggcc ccctgccctt ctcctgggac     1320

atcctgtccc ctcagttcat gtacggctcc agggccttca ccaagcaccc cgccgacatc     1380

cccgactact ataagcagtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc     1440

gaggacggcg gcgccgtgac cgtgacccag gacacctccc tggaggacgg caccctgatc     1500

tacaaggtga agctccgcgg caccaacttc cctcctgacg gccccgtaat gcagaagaag     1560

acaatgggct gggaagcgtc caccgagcgg ttgtaccccg aggacggcgt gctgaagggc     1620

gacattaaga tggccctgcg cctgaaggac ggcggacgct acctggcgga cttcaagacc     1680

acctacaagg ccaagaagcc cgtgcagatg cccggcgcct acaacgtcga ccgcaagttg     1740

gacatcacct cccacaacga ggactacacc gtggtggaac agtacgaacg ctccgagggc     1800

cgccactcca ccggcggcat ggacgagctg tacaagttct gctacgagaa cgaggtgtaa     1860


<210>  37
<211>  341
<212>  PRT
<213>  Artificial sequence

<220>
<223>  zPP1 aa sequence

<400>  37

Met His Glu Glu Met Glu Ser Glu Thr Ser Thr Ala Ala Ser Gly Ser 
1               5                   10                  15      


Ile Ala Glu Val Met Pro Arg Thr Gly Tyr Thr Ile Leu Ala Val Ile 
            20                  25                  30          


Ile Gly Val Phe Ser Val Cys Gly Val Ile Leu Asn Val Thr Val Ile 
        35                  40                  45              


Thr Val Thr Leu Lys Tyr Lys Gln Leu Arg Gln Pro Leu Asn Phe Ala 
    50                  55                  60                  


Leu Val Asn Leu Ala Val Ala Asp Leu Gly Cys Ala Val Phe Gly Gly 
65                  70                  75                  80  


Leu Pro Thr Val Val Thr Asn Ala Met Gly Tyr Phe Ser Leu Gly Arg 
                85                  90                  95      


Val Gly Cys Val Leu Glu Gly Phe Ala Val Ala Phe Phe Gly Ile Ala 
            100                 105                 110         


Ala Leu Cys Ser Val Ala Val Ile Ala Leu Glu Arg Cys Met Val Val 
        115                 120                 125             


Cys Arg Pro Val Gly Ser Ile Ser Phe Gln Thr Arg His Ala Val Phe 
    130                 135                 140                 


Gly Val Ala Val Ser Trp Val Trp Ser Phe Ile Trp Asn Thr Pro Pro 
145                 150                 155                 160 


Leu Phe Gly Trp Gly Arg Phe Glu Leu Glu Gly Val Arg Thr Ser Cys 
                165                 170                 175     


Ala Pro Asp Trp Tyr Ser Arg Asp Leu Ala Asn Val Ser Phe Ile Val 
            180                 185                 190         


Cys Tyr Phe Leu Leu Cys Phe Ala Leu Pro Phe Ser Val Ile Val Tyr 
        195                 200                 205             


Ser Tyr Thr Arg Leu Leu Trp Thr Leu Arg Gln Val Ser Arg Leu Gln 
    210                 215                 220                 


Val Cys Glu Gly Gly Ser Ala Ala Arg Ala Glu Ala Gln Val Ser Cys 
225                 230                 235                 240 


Met Val Val Val Met Ile Leu Ala Phe Leu Leu Thr Trp Leu Pro Tyr 
                245                 250                 255     


Ala Ser Phe Ala Leu Cys Val Ile Leu Ile Pro Glu Leu Tyr Ile Asp 
            260                 265                 270         


Pro Val Ile Ala Thr Val Pro Met Tyr Leu Thr Lys Ser Ser Thr Val 
        275                 280                 285             


Phe Asn Pro Ile Ile Tyr Ile Phe Met Asn Arg Gln Phe Arg Asp Arg 
    290                 295                 300                 


Ala Leu Pro Phe Leu Leu Cys Gly Arg Asn Pro Trp Ala Ala Glu Ala 
305                 310                 315                 320 


Glu Glu Glu Glu Glu Glu Thr Thr Val Ser Ser Val Ser Arg Ser Thr 
                325                 330                 335     


Ser Val Ser Pro Ala 
            340     


<210>  38
<211>  1023
<212>  DNA
<213>  Artificial sequence

<220>
<223>  zPP1 na sequence

<400>  38
atgcacgagg aaatggaatc agaaacatct acagcggcct ctgggagcat tgctgaggtg       60

atgccccgca ctggatatac catacttgca gtgattatcg gggtcttttc agtctgcggt      120

gtaatactga acgtaaccgt tattaccgtc acacttaaat acaaacagtt gcgtcaacct      180

ctgaattttg cgctcgttaa tctggccgta gcagacctgg gatgtgcggt ctttggtggc      240

cttccaacgg ttgtcacaaa tgccatggga tatttctctt tgggccgcgt cggctgcgta      300

ctcgaaggat tcgctgttgc tttcttcggt atcgctgcat tgtgcagcgt cgccgtaatt      360

gctctcgaac ggtgcatggt ggtctgcaga cccgtggggt caatcagttt ccaaaccaga      420

catgccgtgt ttggagttgc cgtgagctgg gtatggtcat ttatctggaa cacaccccct      480

ctcttcggtt ggggcaggtt tgaacttgag ggagtgcgga cgagttgcgc tccagattgg      540

tacagtagag atcttgccaa tgtcagcttt atagtttgtt acttcttgct gtgttttgcc      600

ttgcctttct ctgtgattgt atacagctac actcgtttgc tctggacact ccgacaagta      660

tctcggctgc aagtatgtga aggcggttct gcggcacgcg ctgaagctca agtatcctgc      720

atggtagtgg tcatgatact cgcttttctc ctcacttggc tgccatatgc aagtttcgct      780

ttgtgtgtta tcctcatacc tgagctctat atcgaccctg tcatcgccac ggtcccaatg      840

tatctcacaa aatcctcaac tgtcttcaac cctatcatct atatatttat gaatcggcag      900

tttagggacc gtgctctccc gtttctgctg tgcgggagaa atccatgggc tgcggaagcc      960

gaggaagaag aagaggaaac aaccgtgtca agcgtcagca ggtccactag cgtaagcccc     1020

gcg                                                                   1023


<210>  39
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  zPP1 -mScarlet open reading frame AA sequence

<400>  39

Met His Glu Glu Met Glu Ser Glu Thr Ser Thr Ala Ala Ser Gly Ser 
1               5                   10                  15      


Ile Ala Glu Val Met Pro Arg Thr Gly Tyr Thr Ile Leu Ala Val Ile 
            20                  25                  30          


Ile Gly Val Phe Ser Val Cys Gly Val Ile Leu Asn Val Thr Val Ile 
        35                  40                  45              


Thr Val Thr Leu Lys Tyr Lys Gln Leu Arg Gln Pro Leu Asn Phe Ala 
    50                  55                  60                  


Leu Val Asn Leu Ala Val Ala Asp Leu Gly Cys Ala Val Phe Gly Gly 
65                  70                  75                  80  


Leu Pro Thr Val Val Thr Asn Ala Met Gly Tyr Phe Ser Leu Gly Arg 
                85                  90                  95      


Val Gly Cys Val Leu Glu Gly Phe Ala Val Ala Phe Phe Gly Ile Ala 
            100                 105                 110         


Ala Leu Cys Ser Val Ala Val Ile Ala Leu Glu Arg Cys Met Val Val 
        115                 120                 125             


Cys Arg Pro Val Gly Ser Ile Ser Phe Gln Thr Arg His Ala Val Phe 
    130                 135                 140                 


Gly Val Ala Val Ser Trp Val Trp Ser Phe Ile Trp Asn Thr Pro Pro 
145                 150                 155                 160 


Leu Phe Gly Trp Gly Arg Phe Glu Leu Glu Gly Val Arg Thr Ser Cys 
                165                 170                 175     


Ala Pro Asp Trp Tyr Ser Arg Asp Leu Ala Asn Val Ser Phe Ile Val 
            180                 185                 190         


Cys Tyr Phe Leu Leu Cys Phe Ala Leu Pro Phe Ser Val Ile Val Tyr 
        195                 200                 205             


Ser Tyr Thr Arg Leu Leu Trp Thr Leu Arg Gln Val Ser Arg Leu Gln 
    210                 215                 220                 


Val Cys Glu Gly Gly Ser Ala Ala Arg Ala Glu Ala Gln Val Ser Cys 
225                 230                 235                 240 


Met Val Val Val Met Ile Leu Ala Phe Leu Leu Thr Trp Leu Pro Tyr 
                245                 250                 255     


Ala Ser Phe Ala Leu Cys Val Ile Leu Ile Pro Glu Leu Tyr Ile Asp 
            260                 265                 270         


Pro Val Ile Ala Thr Val Pro Met Tyr Leu Thr Lys Ser Ser Thr Val 
        275                 280                 285             


Phe Asn Pro Ile Ile Tyr Ile Phe Met Asn Arg Gln Phe Arg Asp Arg 
    290                 295                 300                 


Ala Leu Pro Phe Leu Leu Cys Gly Arg Asn Pro Trp Ala Ala Glu Ala 
305                 310                 315                 320 


Glu Glu Glu Glu Glu Glu Thr Thr Val Ser Ser Val Ser Arg Ser Thr 
                325                 330                 335     


Ser Val Ser Pro Ala Thr Glu Thr Ser Gln Val Ala Pro Ala Pro Arg 
            340                 345                 350         


Ala Arg Asp Pro Thr Gly Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr 
        355                 360                 365             


Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Val Met Val Ser Lys Gly 
    370                 375                 380                 


Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly 
385                 390                 395                 400 


Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg 
                405                 410                 415     


Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly 
            420                 425                 430         


Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly 
        435                 440                 445             


Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile Pro Asp Tyr Tyr Lys 
    450                 455                 460                 


Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu 
465                 470                 475                 480 


Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr Ser Leu Glu Asp Gly 
                485                 490                 495     


Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Pro Asp 
            500                 505                 510         


Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Thr Glu 
        515                 520                 525             


Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly Asp Ile Lys Met Ala 
    530                 535                 540                 


Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala Asp Phe Lys Thr Thr 
545                 550                 555                 560 


Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly Ala Tyr Asn Val Asp 
                565                 570                 575     


Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Val Val Glu 
            580                 585                 590         


Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu 
        595                 600                 605             


Leu Tyr Lys Phe Cys Tyr Glu Asn Glu Val 
    610                 615             


<210>  40
<211>  1857
<212>  DNA
<213>  Artificial sequence

<220>
<223>  zPP1 -mScarlet open reading frame NA sequence

<400>  40
atgcacgagg aaatggaatc agaaacatct acagcggcct ctgggagcat tgctgaggtg       60

atgccccgca ctggatatac catacttgca gtgattatcg gggtcttttc agtctgcggt      120

gtaatactga acgtaaccgt tattaccgtc acacttaaat acaaacagtt gcgtcaacct      180

ctgaattttg cgctcgttaa tctggccgta gcagacctgg gatgtgcggt ctttggtggc      240

cttccaacgg ttgtcacaaa tgccatggga tatttctctt tgggccgcgt cggctgcgta      300

ctcgaaggat tcgctgttgc tttcttcggt atcgctgcat tgtgcagcgt cgccgtaatt      360

gctctcgaac ggtgcatggt ggtctgcaga cccgtggggt caatcagttt ccaaaccaga      420

catgccgtgt ttggagttgc cgtgagctgg gtatggtcat ttatctggaa cacaccccct      480

ctcttcggtt ggggcaggtt tgaacttgag ggagtgcgga cgagttgcgc tccagattgg      540

tacagtagag atcttgccaa tgtcagcttt atagtttgtt acttcttgct gtgttttgcc      600

ttgcctttct ctgtgattgt atacagctac actcgtttgc tctggacact ccgacaagta      660

tctcggctgc aagtatgtga aggcggttct gcggcacgcg ctgaagctca agtatcctgc      720

atggtagtgg tcatgatact cgcttttctc ctcacttggc tgccatatgc aagtttcgct      780

ttgtgtgtta tcctcatacc tgagctctat atcgaccctg tcatcgccac ggtcccaatg      840

tatctcacaa aatcctcaac tgtcttcaac cctatcatct atatatttat gaatcggcag      900

tttagggacc gtgctctccc gtttctgctg tgcgggagaa atccatgggc tgcggaagcc      960

gaggaagaag aagaggaaac aaccgtgtca agcgtcagca ggtccactag cgtaagcccc     1020

gcgacagaaa caagtcaagt tgcgcccgcc ccgcgagccc gagatccaac cggtaagagc     1080

aggatcacca gcgagggcga gtacatcccc ctggaccaga tcgacatcaa cgtggtgatg     1140

gtgagcaagg gcgaggcagt gatcaaggag ttcatgcggt tcaaggtgca catggagggc     1200

tccatgaacg gccacgagtt cgagatcgag ggcgagggcg agggccgccc ctacgagggc     1260

acccagaccg ccaagctgaa ggtgaccaag ggtggccccc tgcccttctc ctgggacatc     1320

ctgtcccctc agttcatgta cggctccagg gccttcacca agcaccccgc cgacatcccc     1380

gactactata agcagtcctt ccccgagggc ttcaagtggg agcgcgtgat gaacttcgag     1440

gacggcggcg ccgtgaccgt gacccaggac acctccctgg aggacggcac cctgatctac     1500

aaggtgaagc tccgcggcac caacttccct cctgacggcc ccgtaatgca gaagaagaca     1560

atgggctggg aagcgtccac cgagcggttg taccccgagg acggcgtgct gaagggcgac     1620

attaagatgg ccctgcgcct gaaggacggc ggacgctacc tggcggactt caagaccacc     1680

tacaaggcca agaagcccgt gcagatgccc ggcgcctaca acgtcgaccg caagttggac     1740

atcacctccc acaacgagga ctacaccgtg gtggaacagt acgaacgctc cgagggccgc     1800

cactccaccg gcggcatgga cgagctgtac aagttctgct acgagaacga ggtgtaa        1857


<210>  41
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  pPP2 aa sequence

<400>  41

Met Lys Pro Ser Ala Phe Tyr Leu Asn Ala Ser Leu Tyr Leu Gly Pro 
1               5                   10                  15      


Gln Gly Glu Pro Pro Leu Pro Arg Ser Gly Phe Ile Ala Leu Ser Val 
            20                  25                  30          


Ile Met Ala Leu Leu Thr Gly Pro Ala Ile Val Leu Asn Ala Thr Val 
        35                  40                  45              


Ile Ile Val Ser Leu Met His Lys Gln Leu Arg Gln Pro Leu Asn Tyr 
    50                  55                  60                  


Ala Leu Val Asn Met Ala Val Ala Asp Leu Gly Thr Ala Met Thr Gly 
65                  70                  75                  80  


Gly Leu Leu Ser Val Val Asn Asn Ala Gln Gly Tyr Phe Ser Leu Gly 
                85                  90                  95      


Arg Thr Gly Cys Val Leu Glu Gly Phe Ala Val Ser Leu Cys Gly Ile 
            100                 105                 110         


Ala Ser Leu Cys Thr Val Ala Leu Ile Ala Val Glu Arg Met Phe Val 
        115                 120                 125             


Ile Cys Lys Pro Leu Gly Gln Met Gln Phe Gln Lys Gln His Ala Leu 
    130                 135                 140                 


Gly Gly Ile Ala Leu Ala Trp Leu Trp Ser Leu Thr Trp Asn Leu Pro 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Gly Arg Tyr Glu Leu Glu Gly Val Gly Thr Ser 
                165                 170                 175     


Cys Ala Pro Asp Trp His Ser Arg Glu Pro Gln Asn Val Ser Tyr Val 
            180                 185                 190         


Leu Ala Tyr Phe Thr Val Cys Phe Ala Ala Pro Phe Val Ile Ile Leu 
        195                 200                 205             


Val Ser Tyr Ser Lys Leu Met Trp Thr Leu His Lys Val Thr Lys Met 
    210                 215                 220                 


Ala Cys Met Glu Gly Gly Ala Val Ala Lys Ser Glu Met Thr Val Ala 
225                 230                 235                 240 


Tyr Met Val Ile Leu Met Val Val Thr Phe Leu Ile Ser Trp Leu Pro 
                245                 250                 255     


Tyr Ala Gly Leu Ser Met Leu Val Val Leu Ser Pro Asp Val Lys Ile 
            260                 265                 270         


His Pro Leu Val Gly Thr Val Pro Val Tyr Leu Ala Lys Ser Ser Thr 
        275                 280                 285             


Val Tyr Asn Pro Ile Ile Tyr Ile Tyr Leu Asn Lys Gln Phe Arg Lys 
    290                 295                 300                 


Tyr Ala Val Pro Phe Leu Leu Cys Gly Arg Glu Leu Glu Met Glu Asp 
305                 310                 315                 320 


Glu Leu Ser Met Thr Thr Val Glu Thr Ser Asn Arg Val Ser Pro Ala 
                325                 330                 335     


<210>  42
<211>  1008
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pPP2 na sequence

<400>  42
atgaagcctt ctgcattcta cctaaatgca agtctgtacc tcgggccaca gggagagccc       60

ccactgcctc ggagtggctt tattgctctg tctgtgatca tggctttgct cacaggtcca      120

gccatagtct tgaacgctac agtgataatc gtgtccctca tgcataaaca actaaggcag      180

cctttgaatt atgcgctcgt taatatggca gtggccgatc ttggtacagc tatgacgggc      240

ggcctgctgt ctgtggtgaa taatgcgcaa ggatacttta gcctgggcag aacaggttgc      300

gtactggaag gttttgctgt tagtctctgc ggcattgcat ctctgtgtac ggtggcactg      360

atcgccgtcg aacgcatgtt cgtcatttgt aaacctctgg gccaaatgca attccaaaag      420

cagcacgcat tgggcggcat cgccctggct tggctttggt ctctgacatg gaatctccca      480

cccctctttg ggtggggcag atatgaactt gagggtgtgg gcacctcatg cgcgcccgac      540

tggcatagcc gggagccaca aaatgtatca tacgtccttg cttatttcac tgtgtgtttt      600

gccgcaccat ttgttatcat tctggtctca tatagcaaac tgatgtggac tctgcacaaa      660

gtcactaaaa tggcttgtat ggaaggtgga gcagtcgcaa agtctgaaat gaccgtggcc      720

tacatggtta tcctcatggt agttacattc ttgatcagct ggctccccta cgccgggctc      780

agcatgctcg tggttctcag cccggatgtg aagatacacc cgcttgtggg tactgttcct      840

gtgtacctgg ctaaatcctc tacagtatac aatcccatca tttacattta tttgaacaaa      900

caattccgca agtacgccgt cccatttctg ctctgcggcc gggaactcga aatggaagac      960

gagctttcca tgactacagt agaaactagc aatagagtta gccctgcc                  1008


<210>  43
<211>  613
<212>  PRT
<213>  Artificial sequence

<220>
<223>  pPP2 -mScarlet open reading frame AA sequence

<400>  43

Met Lys Pro Ser Ala Phe Tyr Leu Asn Ala Ser Leu Tyr Leu Gly Pro 
1               5                   10                  15      


Gln Gly Glu Pro Pro Leu Pro Arg Ser Gly Phe Ile Ala Leu Ser Val 
            20                  25                  30          


Ile Met Ala Leu Leu Thr Gly Pro Ala Ile Val Leu Asn Ala Thr Val 
        35                  40                  45              


Ile Ile Val Ser Leu Met His Lys Gln Leu Arg Gln Pro Leu Asn Tyr 
    50                  55                  60                  


Ala Leu Val Asn Met Ala Val Ala Asp Leu Gly Thr Ala Met Thr Gly 
65                  70                  75                  80  


Gly Leu Leu Ser Val Val Asn Asn Ala Gln Gly Tyr Phe Ser Leu Gly 
                85                  90                  95      


Arg Thr Gly Cys Val Leu Glu Gly Phe Ala Val Ser Leu Cys Gly Ile 
            100                 105                 110         


Ala Ser Leu Cys Thr Val Ala Leu Ile Ala Val Glu Arg Met Phe Val 
        115                 120                 125             


Ile Cys Lys Pro Leu Gly Gln Met Gln Phe Gln Lys Gln His Ala Leu 
    130                 135                 140                 


Gly Gly Ile Ala Leu Ala Trp Leu Trp Ser Leu Thr Trp Asn Leu Pro 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Gly Arg Tyr Glu Leu Glu Gly Val Gly Thr Ser 
                165                 170                 175     


Cys Ala Pro Asp Trp His Ser Arg Glu Pro Gln Asn Val Ser Tyr Val 
            180                 185                 190         


Leu Ala Tyr Phe Thr Val Cys Phe Ala Ala Pro Phe Val Ile Ile Leu 
        195                 200                 205             


Val Ser Tyr Ser Lys Leu Met Trp Thr Leu His Lys Val Thr Lys Met 
    210                 215                 220                 


Ala Cys Met Glu Gly Gly Ala Val Ala Lys Ser Glu Met Thr Val Ala 
225                 230                 235                 240 


Tyr Met Val Ile Leu Met Val Val Thr Phe Leu Ile Ser Trp Leu Pro 
                245                 250                 255     


Tyr Ala Gly Leu Ser Met Leu Val Val Leu Ser Pro Asp Val Lys Ile 
            260                 265                 270         


His Pro Leu Val Gly Thr Val Pro Val Tyr Leu Ala Lys Ser Ser Thr 
        275                 280                 285             


Val Tyr Asn Pro Ile Ile Tyr Ile Tyr Leu Asn Lys Gln Phe Arg Lys 
    290                 295                 300                 


Tyr Ala Val Pro Phe Leu Leu Cys Gly Arg Glu Leu Glu Met Glu Asp 
305                 310                 315                 320 


Glu Leu Ser Met Thr Thr Val Glu Thr Ser Asn Arg Val Ser Pro Ala 
                325                 330                 335     


Thr Glu Thr Ser Gln Val Ala Pro Ala Pro Arg Ala Arg Asp Pro Thr 
            340                 345                 350         


Gly Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln 
        355                 360                 365             


Ile Asp Ile Asn Val Val Met Val Ser Lys Gly Glu Ala Val Ile Lys 
    370                 375                 380                 


Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Met Asn Gly His 
385                 390                 395                 400 


Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr 
                405                 410                 415     


Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ser 
            420                 425                 430         


Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr 
        435                 440                 445             


Lys His Pro Ala Asp Ile Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu 
    450                 455                 460                 


Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Ala Val 
465                 470                 475                 480 


Thr Val Thr Gln Asp Thr Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys 
                485                 490                 495     


Val Lys Leu Arg Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln 
            500                 505                 510         


Lys Lys Thr Met Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu 
        515                 520                 525             


Asp Gly Val Leu Lys Gly Asp Ile Lys Met Ala Leu Arg Leu Lys Asp 
    530                 535                 540                 


Gly Gly Arg Tyr Leu Ala Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys 
545                 550                 555                 560 


Pro Val Gln Met Pro Gly Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile 
                565                 570                 575     


Thr Ser His Asn Glu Asp Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser 
            580                 585                 590         


Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Phe Cys 
        595                 600                 605             


Tyr Glu Asn Glu Val 
    610             


<210>  44
<211>  1842
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pPP2 -mScarlet open reading frame NA sequence

<400>  44
atgaagcctt ctgcattcta cctaaatgca agtctgtacc tcgggccaca gggagagccc       60

ccactgcctc ggagtggctt tattgctctg tctgtgatca tggctttgct cacaggtcca      120

gccatagtct tgaacgctac agtgataatc gtgtccctca tgcataaaca actaaggcag      180

cctttgaatt atgcgctcgt taatatggca gtggccgatc ttggtacagc tatgacgggc      240

ggcctgctgt ctgtggtgaa taatgcgcaa ggatacttta gcctgggcag aacaggttgc      300

gtactggaag gttttgctgt tagtctctgc ggcattgcat ctctgtgtac ggtggcactg      360

atcgccgtcg aacgcatgtt cgtcatttgt aaacctctgg gccaaatgca attccaaaag      420

cagcacgcat tgggcggcat cgccctggct tggctttggt ctctgacatg gaatctccca      480

cccctctttg ggtggggcag atatgaactt gagggtgtgg gcacctcatg cgcgcccgac      540

tggcatagcc gggagccaca aaatgtatca tacgtccttg cttatttcac tgtgtgtttt      600

gccgcaccat ttgttatcat tctggtctca tatagcaaac tgatgtggac tctgcacaaa      660

gtcactaaaa tggcttgtat ggaaggtgga gcagtcgcaa agtctgaaat gaccgtggcc      720

tacatggtta tcctcatggt agttacattc ttgatcagct ggctccccta cgccgggctc      780

agcatgctcg tggttctcag cccggatgtg aagatacacc cgcttgtggg tactgttcct      840

gtgtacctgg ctaaatcctc tacagtatac aatcccatca tttacattta tttgaacaaa      900

caattccgca agtacgccgt cccatttctg ctctgcggcc gggaactcga aatggaagac      960

gagctttcca tgactacagt agaaactagc aatagagtta gccctgccac agaaactagt     1020

caagtagccc ctgctccgcg agcccgagat ccaaccggta agagcaggat caccagcgag     1080

ggcgagtaca tccccctgga ccagatcgac atcaacgtgg tgatggtgag caagggcgag     1140

gcagtgatca aggagttcat gcggttcaag gtgcacatgg agggctccat gaacggccac     1200

gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag     1260

ctgaaggtga ccaagggtgg ccccctgccc ttctcctggg acatcctgtc ccctcagttc     1320

atgtacggct ccagggcctt caccaagcac cccgccgaca tccccgacta ctataagcag     1380

tccttccccg agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgccgtg     1440

accgtgaccc aggacacctc cctggaggac ggcaccctga tctacaaggt gaagctccgc     1500

ggcaccaact tccctcctga cggccccgta atgcagaaga agacaatggg ctgggaagcg     1560

tccaccgagc ggttgtaccc cgaggacggc gtgctgaagg gcgacattaa gatggccctg     1620

cgcctgaagg acggcggacg ctacctggcg gacttcaaga ccacctacaa ggccaagaag     1680

cccgtgcaga tgcccggcgc ctacaacgtc gaccgcaagt tggacatcac ctcccacaac     1740

gaggactaca ccgtggtgga acagtacgaa cgctccgagg gccgccactc caccggcggc     1800

atggacgagc tgtacaagtt ctgctacgag aacgaggtgt aa                        1842


