                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       CARMI, Yaron
       RIDER, Peleg
       RASOULOUNIRIANA, Diana
 
<120>  T CELL EXPRESSING AN FC GAMMA RECEPTOR AND METHODS OF USE THEREOF

<130>  81398

<150>  US 62/820,357
<151>  2019-03-19

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  1
agacaccgct acacatctgc                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
gggaagtttg tgccccagta                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
gcattctgag aggatgcggt                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
tggccttggc cttcctattc                                                   20


<210>  5
<211>  404
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc-gamma receptor 1 (CD64) AA SEQUENCE

<400>  5

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


Lys Ile His Arg Leu Gln Arg Glu Lys Lys Tyr Asn Leu Glu Val Pro 
                325                 330                 335     


Leu Val Ser Glu Gln Gly Lys Lys Ala Asn Ser Phe Gln Gln Val Arg 
            340                 345                 350         


Ser Asp Gly Val Tyr Glu Glu Val Thr Ala Thr Ala Ser Gln Thr Thr 
        355                 360                 365             


Pro Lys Glu Ala Pro Asp Gly Pro Arg Ser Ser Val Gly Asp Cys Gly 
    370                 375                 380                 


Pro Glu Gln Pro Glu Pro Leu Pro Pro Ser Asp Ser Thr Gly Ala Gln 
385                 390                 395                 400 


Thr Ser Gln Ser 
                


<210>  6
<211>  1215
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fc-gamma receptor 1 (CD64) NA SEQUENCE

<400>  6
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960

aaaatacaca ggctgcagag agagaagaaa tacaacttag aagtcccttt ggtttctgag     1020

cagggaaaga aagcaaattc ctttcagcaa gttagaagcg atggcgtgta tgaagaagta     1080

acagccactg cgagccagac cacaccaaaa gaagcgcccg atggacctcg aagctcagtg     1140

ggtgactgtg gacccgagca gcctgaaccc cttcctccca gtgacagtac tggggcacaa     1200

acttcccaaa gttga                                                      1215


<210>  7
<211>  273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extracellular domain of CD64 AA sequence

<400>  7

Glu Val Val Asn Ala Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp 
1               5                   10                  15      


Val Ser Ile Phe Gln Lys Glu Asn Val Thr Leu Trp Cys Glu Gly Pro 
            20                  25                  30          


His Leu Pro Gly Asp Ser Ser Thr Gln Trp Phe Ile Asn Gly Thr Ala 
        35                  40                  45              


Val Gln Ile Ser Thr Pro Ser Tyr Ser Ile Pro Glu Ala Ser Phe Gln 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Ile Gly Ser Ser Met Pro Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Gln Ile His Asn Asp Trp Leu Leu Leu Gln Ala Ser 
                85                  90                  95      


Arg Arg Val Leu Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Gly 
            100                 105                 110         


Trp Lys Asn Lys Leu Val Tyr Asn Val Val Phe Tyr Arg Asn Gly Lys 
        115                 120                 125             


Ser Phe Gln Phe Ser Ser Asp Ser Glu Val Ala Ile Leu Lys Thr Asn 
    130                 135                 140                 


Leu Ser His Ser Gly Ile Tyr His Cys Ser Gly Thr Gly Arg His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Val Ser Ile Thr Val Lys Glu Leu Phe Thr Thr 
                165                 170                 175     


Pro Val Leu Arg Ala Ser Val Ser Ser Pro Phe Pro Glu Gly Ser Leu 
            180                 185                 190         


Val Thr Leu Asn Cys Glu Thr Asn Leu Leu Leu Gln Arg Pro Gly Leu 
        195                 200                 205             


Gln Leu His Phe Ser Phe Tyr Val Gly Ser Lys Ile Leu Glu Tyr Arg 
    210                 215                 220                 


Asn Thr Ser Ser Glu Tyr His Ile Ala Arg Ala Glu Arg Glu Asp Ala 
225                 230                 235                 240 


Gly Phe Tyr Trp Cys Glu Val Ala Thr Glu Asp Ser Ser Val Leu Lys 
                245                 250                 255     


Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Pro Gln Ser Ser Ala 
            260                 265                 270         


Pro 
    


<210>  8
<211>  819
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Extracellular domain of CD64 NA sequence

<400>  8
gaagtggtta atgccaccaa ggctgtgatc accttgcagc ctccatgggt cagtattttc       60

cagaaggaaa atgtcacttt atggtgtgag gggcctcacc tgcctggaga cagttccaca      120

caatggttta tcaacggaac agccgttcag atctccacgc ctagttatag catcccagag      180

gccagttttc aggacagtgg cgaatacagg tgtcagatag gttcctcaat gccaagtgac      240

cctgtgcagt tgcaaatcca caatgattgg ctgctactcc aggcctcccg cagagtcctc      300

acagaaggag aacccctggc cttgaggtgt cacggatgga agaataaact ggtgtacaat      360

gtggttttct atagaaatgg aaaatccttt cagttttctt cagattcgga ggtcgccatt      420

ctgaaaacca acctgagtca cagcggcatc taccactgct caggcacggg aagacaccgc      480

tacacatctg caggagtgtc catcacggtg aaagagctgt ttaccacgcc agtgctgaga      540

gcatccgtgt catctccctt cccggagggg agtctggtca ccctgaactg tgagacgaat      600

ttgctcctgc agagacccgg cttacagctt cacttctcct tctacgtggg cagcaagatc      660

ctggagtaca ggaacacatc ctcagagtac catatagcaa gggcggaaag agaagatgct      720

ggattctact ggtgtgaggt agccacggag gacagcagtg tccttaagcg cagccctgag      780

ttggagctcc aagtgcttgg tccccagtca tcagctcct                             819


<210>  9
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Transmembrane domain of CD64 AA sequence

<400>  9

Val Trp Phe His Ile Leu Phe Tyr Leu Ser Val Gly Ile Met Phe Ser 
1               5                   10                  15      


Leu Asn Thr Val Leu Tyr Val 
            20              


<210>  10
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Transmembrane domain of CD64 NA sequence

<400>  10
gtctggtttc acatcctgtt ttatctgtca gtgggaataa tgttttcgtt gaacacggtt       60

ctctatgtg                                                               69


<210>  11
<211>  84
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Intracellular domain of CD64 AA sequence

<400>  11

Lys Ile His Arg Leu Gln Arg Glu Lys Lys Tyr Asn Leu Glu Val Pro 
1               5                   10                  15      


Leu Val Ser Glu Gln Gly Lys Lys Ala Asn Ser Phe Gln Gln Val Arg 
            20                  25                  30          


Ser Asp Gly Val Tyr Glu Glu Val Thr Ala Thr Ala Ser Gln Thr Thr 
        35                  40                  45              


Pro Lys Glu Ala Pro Asp Gly Pro Arg Ser Ser Val Gly Asp Cys Gly 
    50                  55                  60                  


Pro Glu Gln Pro Glu Pro Leu Pro Pro Ser Asp Ser Thr Gly Ala Gln 
65                  70                  75                  80  


Thr Ser Gln Ser 
                


<210>  12
<211>  255
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Intracellular domain of CD64 NA sequence

<400>  12
aaaatacaca ggctgcagag agagaagaaa tacaacttag aagtcccttt ggtttctgag       60

cagggaaaga aagcaaattc ctttcagcaa gttagaagcg atggcgtgta tgaagaagta      120

acagccactg cgagccagac cacaccaaaa gaagcgcccg atggacctcg aagctcagtg      180

ggtgactgtg gacccgagca gcctgaaccc cttcctccca gtgacagtac tggggcacaa      240

acttcccaaa gttga                                                       255


<210>  13
<211>  86
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc receptor common Gamma chainAA SEQUENCE

<400>  13

Met Ile Ser Ala Val Ile Leu Phe Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Val Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val 
    50                  55                  60                  


Tyr Thr Gly Leu Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  14
<211>  261
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fc receptor common Gamma chainNA SEQUENCE

<400>  14
atgatctcag ccgtgatctt gttcttgctc cttttggtgg aacaagcagc cgccctggga       60

gagccgcagc tctgctatat cctggatgct gtcctgtttt tgtatggtat tgtccttacc      120

ctactctact gtcgactcaa gatccaggtc cgaaaggcag ctatagccag ccgtgagaaa      180

gcagatgctg tctacacggg cctgaacacc cggagccagg agacatatga gactctgaag      240

catgagaaac caccccagta g                                                261


<210>  15
<211>  86
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc receptor common Gamma chainAA SEQUENCE (in construct)

<400>  15

Met Ile Ser Ala Val Ile Leu Phe Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Val Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val 
    50                  55                  60                  


Tyr Thr Gly Leu Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  16
<211>  261
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fc receptor common Gamma chainNA SEQUENCE (in construct)

<400>  16
atgatctcag ccgtgatctt gttcttgctc cttttggtgg aacaagcagc cgccctggga       60

gagccgcagc tctgctatat cctggatgct gtcctgtttt tgtatggtat tgtccttacc      120

ctactctact gtcgactcaa gatccaggtc cgaaaggcag ctatagccag ccgtgagaaa      180

gcagatgctg tctacacggg cctgaacacc cggagccagg agacatatga gactctgaag      240

catgagaaac caccccagta g                                                261


<210>  17
<211>  164
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD3 zeta AA SEQUENCE

<400>  17

Met Lys Trp Lys Val Ser Val Leu Ala Cys Ile Leu His Val Arg Phe 
1               5                   10                  15      


Pro Gly Ala Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Ile Thr Ala 
        35                  40                  45              


Leu Tyr Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn 
    50                  55                  60                  


Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn 
            100                 105                 110         


Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr 
145                 150                 155                 160 


Leu Ala Pro Arg 
                


<210>  18
<211>  495
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD3zeta NA sequence

<400>  18
atgaagtgga aagtgtctgt tctcgcctgc atcctccacg tgcggttccc aggagcagag       60

gcacagagct ttggtctgct ggatcccaaa ctctgctact tgctagatgg aatcctcttc      120

atctacggag tcatcatcac agccctgtac ctgagagcaa aattcagcag gagtgcagag      180

actgctgcca acctgcagga ccccaaccag ctctacaatg agctcaatct agggcgaaga      240

gaggaatatg acgtcttgga gaagaagcgg gctcgggatc cagagatggg aggcaaacag      300

cagaggagga ggaaccccca ggaaggcgta tacaatgcac tgcagaaaga caagatggca      360

gaagcctaca gtgagatcgg cacaaaaggc gagaggcgga gaggcaaggg gcacgatggc      420

ctttaccagg gtctcagcac tgccaccaag gacacctatg atgccctgca tatgcagacc      480

ctggcccctc gctaa                                                       495


<210>  19
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD3 zeta intracellular  ITAMS domain AA sequence

<400>  19

Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
1               5                   10                  15      


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
            100                 105                 110         


Arg 
    


<210>  20
<211>  339
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD3 zeta intracellular  ITAMS domain NA sequence

<400>  20
agagcaaaat tcagcaggag tgcagagact gctgccaacc tgcaggaccc caaccagctc       60

tacaatgagc tcaatctagg gcgaagagag gaatatgacg tcttggagaa gaagcgggct      120

cgggatccag agatgggagg caaacagcag aggaggagga acccccagga aggcgtatac      180

aatgcactgc agaaagacaa gatggcagaa gcctacagtg agatcggcac aaaaggcgag      240

aggcggagag gcaaggggca cgatggcctt taccagggtc tcagcactgc caccaaggac      300

acctatgatg ccctgcatat gcagaccctg gcccctcgc                             339


<210>  21
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FcgRI-T2A-gamma CONSTRUCT AA SEQUENCE

<400>  21

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


Lys Ile His Arg Leu Gln Arg Glu Lys Lys Tyr Asn Leu Glu Val Pro 
                325                 330                 335     


Leu Val Ser Glu Gln Gly Lys Lys Ala Asn Ser Phe Gln Gln Val Arg 
            340                 345                 350         


Ser Asp Gly Val Tyr Glu Glu Val Thr Ala Thr Ala Ser Gln Thr Thr 
        355                 360                 365             


Pro Lys Glu Ala Pro Asp Gly Pro Arg Ser Ser Val Gly Asp Cys Gly 
    370                 375                 380                 


Pro Glu Gln Pro Glu Pro Leu Pro Pro Ser Asp Ser Thr Gly Ala Gln 
385                 390                 395                 400 


Thr Ser Gln Ser Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
                405                 410                 415     


Glu Glu Asn Pro Gly Pro Met Ile Ser Ala Val Ile Leu Phe Leu Leu 
            420                 425                 430         


Leu Leu Val Glu Gln Ala Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr 
        435                 440                 445             


Ile Leu Asp Ala Val Leu Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu 
    450                 455                 460                 


Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Ala Ser Arg 
465                 470                 475                 480 


Glu Lys Ala Asp Ala Val Tyr Thr Gly Leu Asn Thr Arg Ser Gln Glu 
                485                 490                 495     


Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
            500                 505             


<210>  22
<211>  1527
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FcgRI-T2A-gamma CONSTRUCT NA SEQUENCE

<400>  22
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960

aaaatacaca ggctgcagag agagaagaaa tacaacttag aagtcccttt ggtttctgag     1020

cagggaaaga aagcaaattc ctttcagcaa gttagaagcg atggcgtgta tgaagaagta     1080

acagccactg cgagccagac cacaccaaaa gaagcgcccg atggacctcg aagctcagtg     1140

ggtgactgtg gacccgagca gcctgaaccc cttcctccca gtgacagtac tggggcacaa     1200

acttcccaaa gtgagggcag aggaagtctg ctaacatgcg gtgacgtcga ggagaatcct     1260

ggcccaatga tctcagccgt gatcttgttc ttgctccttt tggtggaaca agcagccgcc     1320

ctgggagagc cgcagctctg ctatatcctg gatgctgtcc tgtttttgta tggtattgtc     1380

cttaccctac tctactgtcg actcaagatc caggtccgaa aggcagctat agccagccgt     1440

gagaaagcag atgctgtcta cacgggcctg aacacccgga gccaggagac atatgagact     1500

ctgaagcatg agaaaccacc ccagtag                                         1527


<210>  23
<211>  621
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FcgRI-T2A-FcRg-CD3zeta CONSTRUCT AA SEQUENCE

<400>  23

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


Lys Ile His Arg Leu Gln Arg Glu Lys Lys Tyr Asn Leu Glu Val Pro 
                325                 330                 335     


Leu Val Ser Glu Gln Gly Lys Lys Ala Asn Ser Phe Gln Gln Val Arg 
            340                 345                 350         


Ser Asp Gly Val Tyr Glu Glu Val Thr Ala Thr Ala Ser Gln Thr Thr 
        355                 360                 365             


Pro Lys Glu Ala Pro Asp Gly Pro Arg Ser Ser Val Gly Asp Cys Gly 
    370                 375                 380                 


Pro Glu Gln Pro Glu Pro Leu Pro Pro Ser Asp Ser Thr Gly Ala Gln 
385                 390                 395                 400 


Thr Ser Gln Ser Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
                405                 410                 415     


Glu Glu Asn Pro Gly Pro Met Ile Ser Ala Val Ile Leu Phe Leu Leu 
            420                 425                 430         


Leu Leu Val Glu Gln Ala Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr 
        435                 440                 445             


Ile Leu Asp Ala Val Leu Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu 
    450                 455                 460                 


Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Ala Ser Arg 
465                 470                 475                 480 


Glu Lys Ala Asp Ala Val Tyr Thr Gly Leu Asn Thr Arg Ser Gln Glu 
                485                 490                 495     


Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln Arg Ala Lys Phe 
            500                 505                 510         


Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu 
        515                 520                 525             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu 
    530                 535                 540                 


Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg 
545                 550                 555                 560 


Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met 
                565                 570                 575     


Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly 
            580                 585                 590         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        595                 600                 605             


Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
    610                 615                 620     


<210>  24
<211>  1866
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FcgRI-T2A-FcRg-CD3zeta CONSTRUCT NA SEQUENCE

<400>  24
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960

aaaatacaca ggctgcagag agagaagaaa tacaacttag aagtcccttt ggtttctgag     1020

cagggaaaga aagcaaattc ctttcagcaa gttagaagcg atggcgtgta tgaagaagta     1080

acagccactg cgagccagac cacaccaaaa gaagcgcccg atggacctcg aagctcagtg     1140

ggtgactgtg gacccgagca gcctgaaccc cttcctccca gtgacagtac tggggcacaa     1200

acttcccaaa gtgagggcag aggaagtctg ctaacatgcg gtgacgtcga ggagaatcct     1260

ggcccaatga tctcagccgt gatcttgttc ttgctccttt tggtggaaca agcagccgcc     1320

ctgggagagc cgcagctctg ctatatcctg gatgctgtcc tgtttttgta tggtattgtc     1380

cttaccctac tctactgtcg actcaagatc caggtccgaa aggcagctat agccagccgt     1440

gagaaagcag atgctgtcta cacgggcctg aacacccgga gccaggagac atatgagact     1500

ctgaagcatg agaaaccacc ccagagagca aaattcagca ggagtgcaga gactgctgcc     1560

aacctgcagg accccaacca gctctacaat gagctcaatc tagggcgaag agaggaatat     1620

gacgtcttgg agaagaagcg ggctcgggat ccagagatgg gaggcaaaca gcagaggagg     1680

aggaaccccc aggaaggcgt atacaatgca ctgcagaaag acaagatggc agaagcctac     1740

agtgagatcg gcacaaaagg cgagaggcgg agaggcaagg ggcacgatgg cctttaccag     1800

ggtctcagca ctgccaccaa ggacacctat gatgccctgc atatgcagac cctggcccct     1860

cgctaa                                                                1866


<210>  25
<211>  517
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FcgRI-CD3zeta CONSTRUCT AA SEQUENCE

<400>  25

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


Lys Ile His Arg Leu Gln Arg Glu Lys Lys Tyr Asn Leu Glu Val Pro 
                325                 330                 335     


Leu Val Ser Glu Gln Gly Lys Lys Ala Asn Ser Phe Gln Gln Val Arg 
            340                 345                 350         


Ser Asp Gly Val Tyr Glu Glu Val Thr Ala Thr Ala Ser Gln Thr Thr 
        355                 360                 365             


Pro Lys Glu Ala Pro Asp Gly Pro Arg Ser Ser Val Gly Asp Cys Gly 
    370                 375                 380                 


Pro Glu Gln Pro Glu Pro Leu Pro Pro Ser Asp Ser Thr Gly Ala Gln 
385                 390                 395                 400 


Thr Ser Gln Ser Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala 
                405                 410                 415     


Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            420                 425                 430         


Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu 
        435                 440                 445             


Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr 
    450                 455                 460                 


Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
465                 470                 475                 480 


Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                485                 490                 495     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            500                 505                 510         


Thr Leu Ala Pro Arg 
        515         


<210>  26
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FcgRI-CD3zeta CONSTRUCT NA SEQUENCE

<400>  26
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960

aaaatacaca ggctgcagag agagaagaaa tacaacttag aagtcccttt ggtttctgag     1020

cagggaaaga aagcaaattc ctttcagcaa gttagaagcg atggcgtgta tgaagaagta     1080

acagccactg cgagccagac cacaccaaaa gaagcgcccg atggacctcg aagctcagtg     1140

ggtgactgtg gacccgagca gcctgaaccc cttcctccca gtgacagtac tggggcacaa     1200

acttcccaaa gtagagcaaa attcagcagg agtgcagaga ctgctgccaa cctgcaggac     1260

cccaaccagc tctacaatga gctcaatcta gggcgaagag aggaatatga cgtcttggag     1320

aagaagcggg ctcgggatcc agagatggga ggcaaacagc agaggaggag gaacccccag     1380

gaaggcgtat acaatgcact gcagaaagac aagatggcag aagcctacag tgagatcggc     1440

acaaaaggcg agaggcggag aggcaagggg cacgatggcc tttaccaggg tctcagcact     1500

gccaccaagg acacctatga tgccctgcat atgcagaccc tggcccctcg ctaa           1554


<210>  27
<211>  621
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FcgRI-CD3zeta-T2A-FcRg CONSTRUCT AA SEQUENCE

<400>  27

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


Lys Ile His Arg Leu Gln Arg Glu Lys Lys Tyr Asn Leu Glu Val Pro 
                325                 330                 335     


Leu Val Ser Glu Gln Gly Lys Lys Ala Asn Ser Phe Gln Gln Val Arg 
            340                 345                 350         


Ser Asp Gly Val Tyr Glu Glu Val Thr Ala Thr Ala Ser Gln Thr Thr 
        355                 360                 365             


Pro Lys Glu Ala Pro Asp Gly Pro Arg Ser Ser Val Gly Asp Cys Gly 
    370                 375                 380                 


Pro Glu Gln Pro Glu Pro Leu Pro Pro Ser Asp Ser Thr Gly Ala Gln 
385                 390                 395                 400 


Thr Ser Gln Ser Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala 
                405                 410                 415     


Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            420                 425                 430         


Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu 
        435                 440                 445             


Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr 
    450                 455                 460                 


Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
465                 470                 475                 480 


Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                485                 490                 495     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            500                 505                 510         


Thr Leu Ala Pro Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
        515                 520                 525             


Val Glu Glu Asn Pro Gly Pro Met Ile Ser Ala Val Ile Leu Phe Leu 
    530                 535                 540                 


Leu Leu Leu Val Glu Gln Ala Ala Ala Leu Gly Glu Pro Gln Leu Cys 
545                 550                 555                 560 


Tyr Ile Leu Asp Ala Val Leu Phe Leu Tyr Gly Ile Val Leu Thr Leu 
                565                 570                 575     


Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Ala Ser 
            580                 585                 590         


Arg Glu Lys Ala Asp Ala Val Tyr Thr Gly Leu Asn Thr Arg Ser Gln 
        595                 600                 605             


Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
    610                 615                 620     


<210>  28
<211>  1866
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FcgRI-CD3zeta-T2A-FcRg CONSTRUCT NA SEQUENCE

<400>  28
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960

aaaatacaca ggctgcagag agagaagaaa tacaacttag aagtcccttt ggtttctgag     1020

cagggaaaga aagcaaattc ctttcagcaa gttagaagcg atggcgtgta tgaagaagta     1080

acagccactg cgagccagac cacaccaaaa gaagcgcccg atggacctcg aagctcagtg     1140

ggtgactgtg gacccgagca gcctgaaccc cttcctccca gtgacagtac tggggcacaa     1200

acttcccaaa gtagagcaaa attcagcagg agtgcagaga ctgctgccaa cctgcaggac     1260

cccaaccagc tctacaatga gctcaatcta gggcgaagag aggaatatga cgtcttggag     1320

aagaagcggg ctcgggatcc agagatggga ggcaaacagc agaggaggag gaacccccag     1380

gaaggcgtat acaatgcact gcagaaagac aagatggcag aagcctacag tgagatcggc     1440

acaaaaggcg agaggcggag aggcaagggg cacgatggcc tttaccaggg tctcagcact     1500

gccaccaagg acacctatga tgccctgcat atgcagaccc tggcccctcg cgagggcaga     1560

ggaagtctgc taacatgcgg tgacgtcgag gagaatcctg gcccaatgat ctcagccgtg     1620

atcttgttct tgctcctttt ggtggaacaa gcagccgccc tgggagagcc gcagctctgc     1680

tatatcctgg atgctgtcct gtttttgtat ggtattgtcc ttaccctact ctactgtcga     1740

ctcaagatcc aggtccgaaa ggcagctata gccagccgtg agaaagcaga tgctgtctac     1800

acgggcctga acacccggag ccaggagaca tatgagactc tgaagcatga gaaaccaccc     1860

cagtag                                                                1866


<210>  29
<211>  388
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FcgRI-FcRg construct AA sequence

<400>  29

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Val Leu Phe Leu 
                325                 330                 335     


Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val 
            340                 345                 350         


Arg Lys Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val Tyr Thr 
        355                 360                 365             


Gly Leu Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys His Glu 
    370                 375                 380                 


Lys Pro Pro Gln 
385             


<210>  30
<211>  1167
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FcgRI-FcRg construct NA sequence

<400>  30
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960

ctgggagagc cgcagctctg ctatatcctg gatgctgtcc tgtttttgta tggtattgtc     1020

cttaccctac tctactgtcg actcaagatc caggtccgaa aggcagctat agccagccgt     1080

gagaaagcag atgctgtcta cacgggcctg aacacccgga gccaggagac atatgagact     1140

ctgaagcatg agaaaccacc ccagtaa                                         1167


<210>  31
<211>  519
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FcgRI-FcRg-CD3zeta construct AA sequence

<400>  31

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


Met Ile Ser Ala Val Ile Leu Phe Leu Leu Leu Leu Val Glu Gln Ala 
                325                 330                 335     


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Val Leu 
            340                 345                 350         


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        355                 360                 365             


Gln Val Arg Lys Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val 
    370                 375                 380                 


Tyr Thr Gly Leu Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys 
385                 390                 395                 400 


His Glu Lys Pro Pro Gln Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr 
                405                 410                 415     


Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            420                 425                 430         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp 
        435                 440                 445             


Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly 
    450                 455                 460                 


Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
465                 470                 475                 480 


Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                485                 490                 495     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            500                 505                 510         


Met Gln Thr Leu Ala Pro Arg 
        515                 


<210>  32
<211>  1560
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FcgRI-FcRg-CD3zeta construct NA sequence

<400>  32
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960

atgatctcag ccgtgatctt gttcttgctc cttttggtgg aacaagcagc cgccctggga     1020

gagccgcagc tctgctatat cctggatgct gtcctgtttt tgtatggtat tgtccttacc     1080

ctactctact gtcgactcaa gatccaggtc cgaaaggcag ctatagccag ccgtgagaaa     1140

gcagatgctg tctacacggg cctgaacacc cggagccagg agacatatga gactctgaag     1200

catgagaaac caccccagag agcaaaattc agcaggagtg cagagactgc tgccaacctg     1260

caggacccca accagctcta caatgagctc aatctagggc gaagagagga atatgacgtc     1320

ttggagaaga agcgggctcg ggatccagag atgggaggca aacagcagag gaggaggaac     1380

ccccaggaag gcgtatacaa tgcactgcag aaagacaaga tggcagaagc ctacagtgag     1440

atcggcacaa aaggcgagag gcggagaggc aaggggcacg atggccttta ccagggtctc     1500

agcactgcca ccaaggacac ctatgatgcc ctgcatatgc agaccctggc ccctcgctaa     1560


<210>  33
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Transmembrane+intracellular domain of CD64 AA sequence

<400>  33

Val Trp Phe His Ile Leu Phe Tyr Leu Ser Val Gly Ile Met Phe Ser 
1               5                   10                  15      


Leu Asn Thr Val Leu Tyr Val 
            20              


<210>  34
<211>  296
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extracellular +transmembrane domain of CD64 AA sequence

<400>  34

Glu Val Val Asn Ala Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp 
1               5                   10                  15      


Val Ser Ile Phe Gln Lys Glu Asn Val Thr Leu Trp Cys Glu Gly Pro 
            20                  25                  30          


His Leu Pro Gly Asp Ser Ser Thr Gln Trp Phe Ile Asn Gly Thr Ala 
        35                  40                  45              


Val Gln Ile Ser Thr Pro Ser Tyr Ser Ile Pro Glu Ala Ser Phe Gln 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Ile Gly Ser Ser Met Pro Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Gln Ile His Asn Asp Trp Leu Leu Leu Gln Ala Ser 
                85                  90                  95      


Arg Arg Val Leu Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Gly 
            100                 105                 110         


Trp Lys Asn Lys Leu Val Tyr Asn Val Val Phe Tyr Arg Asn Gly Lys 
        115                 120                 125             


Ser Phe Gln Phe Ser Ser Asp Ser Glu Val Ala Ile Leu Lys Thr Asn 
    130                 135                 140                 


Leu Ser His Ser Gly Ile Tyr His Cys Ser Gly Thr Gly Arg His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Val Ser Ile Thr Val Lys Glu Leu Phe Thr Thr 
                165                 170                 175     


Pro Val Leu Arg Ala Ser Val Ser Ser Pro Phe Pro Glu Gly Ser Leu 
            180                 185                 190         


Val Thr Leu Asn Cys Glu Thr Asn Leu Leu Leu Gln Arg Pro Gly Leu 
        195                 200                 205             


Gln Leu His Phe Ser Phe Tyr Val Gly Ser Lys Ile Leu Glu Tyr Arg 
    210                 215                 220                 


Asn Thr Ser Ser Glu Tyr His Ile Ala Arg Ala Glu Arg Glu Asp Ala 
225                 230                 235                 240 


Gly Phe Tyr Trp Cys Glu Val Ala Thr Glu Asp Ser Ser Val Leu Lys 
                245                 250                 255     


Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Pro Gln Ser Ser Ala 
            260                 265                 270         


Pro Val Trp Phe His Ile Leu Phe Tyr Leu Ser Val Gly Ile Met Phe 
        275                 280                 285             


Ser Leu Asn Thr Val Leu Tyr Val 
    290                 295     


<210>  35
<211>  591
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRP-1 CD4 TCR (alpha chain, P2A, beta chain)Construct, AA 
       sequence

<400>  35

Met Val Leu Ala Leu Leu Pro Val Leu Gly Ile His Phe Leu Leu Arg 
1               5                   10                  15      


Asp Ala Gln Ala Gln Ser Val Thr Gln Pro Asp Ala Arg Val Thr Val 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Gln Leu Arg Cys Lys Tyr Ser Ser Ser Val 
        35                  40                  45              


Thr Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Arg Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Tyr Ser Gly Asp Pro Val Val Gln Gly Val Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ser Lys Ser Asn Ser Ser Phe His Leu Arg 
                85                  90                  95      


Lys Ala Ser Val His Trp Ser Asp Ser Ala Val Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Ser Asn Asn Asn Arg Ile Phe Phe Gly Asp Gly Thr Gln Leu Val 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Gln Glu Asn Pro 
        275                 280                 285             


Gly Pro Leu Tyr Ser Leu Leu Ala Phe Leu Leu Gly Met Phe Leu Gly 
    290                 295                 300                 


Val Ser Ala Gln Thr Ile His Gln Trp Pro Val Ala Glu Ile Lys Ala 
305                 310                 315                 320 


Val Gly Ser Pro Leu Ser Leu Gly Cys Thr Ile Lys Gly Lys Ser Ser 
                325                 330                 335     


Pro Asn Leu Tyr Trp Tyr Trp Gln Ala Thr Gly Gly Thr Leu Gln Gln 
            340                 345                 350         


Leu Phe Tyr Ser Ile Thr Val Gly Gln Val Glu Ser Val Val Gln Leu 
        355                 360                 365             


Asn Leu Ser Ala Ser Arg Pro Lys Asp Asp Gln Phe Ile Leu Ser Thr 
    370                 375                 380                 


Glu Lys Leu Leu Leu Ser His Ser Gly Phe Tyr Leu Cys Ala Trp Ser 
385                 390                 395                 400 


Pro Gly His Gln Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu 
                405                 410                 415     


Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
            420                 425                 430         


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
        435                 440                 445             


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
    450                 455                 460                 


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala 
465                 470                 475                 480 


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
                485                 490                 495     


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
            500                 505                 510         


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
        515                 520                 525             


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
    530                 535                 540                 


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
545                 550                 555                 560 


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
                565                 570                 575     


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
            580                 585                 590     


<210>  36
<211>  1776
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRP-1 CD4 TCR (alpha chain, P2A, beta chain)Construct, NA 
       sequence

<400>  36
atggtcctgg cgctcctccc agtgctgggg atacactttc tcctgagaga tgcccaagct       60

cagtcagtga cgcagcccga tgctcgtgtc actgtctctg aaggagcctc tctgcagctg      120

agatgcaagt attcctcctc tgtgacacct tatctgttct ggtatgtcca gtacccgcgg      180

caggggctgc agctgctcct caagtactat tccggagacc cagtggttca aggagtgaat      240

ggctttgagg ctgagttcag caagagtaac tcttccttcc acctgcggaa agcctccgtg      300

cactggagcg actcggctgt gtacttctgt gctgtgagct cgaacaataa cagaatcttc      360

tttggtgatg ggacgcagct ggtggtgaag cccaacatcc agaacccaga acctgctgtg      420

taccagttaa aagatcctcg gtctcaggac agcaccctct gcctgttcac cgactttgac      480

tcccaaatca atgtgccgaa aactatggaa tctggaacgt tcatcactga caaaactgtg      540

ctggacatga aagctatgga ttccaagagc aatggggcca ttgcctggag caaccagaca      600

agcttcacct gccaagatat cttcaaagag accaacgcca cctaccccag ttcagacgtt      660

ccctgtgatg ccacgttgac tgagaaaagc tttgaaacag atatgaacct aaactttcaa      720

aacctgtcag ttatgggact ccgaatcctc ctgctgaaag tagccggatt taacctgctc      780

atgacgctga ggctgtggtc cagtggctct ggcgccacga acttctctct gttaaagcaa      840

gcaggagacg tgcaagaaaa ccccggtccc ctgtactctc tccttgcctt tctcctgggc      900

atgttcttgg gtgttagtgc tcagactatc catcaatggc cagttgccga gatcaaggct      960

gtgggcagcc cactgtctct ggggtgtacc ataaagggga aatcaagccc taacctctac     1020

tggtactggc aggccacagg aggcaccctc cagcaactct tctactctat tactgttggc     1080

caggtagagt cggtggtgca actgaacctc tcagcttcca ggccgaagga cgaccaattc     1140

atcctaagca cggagaagct gcttctcagc cactctggct tctacctctg tgcctggagt     1200

ccgggacatc aagacaccca gtactttggg ccaggcactc ggctcctcgt gttagaggat     1260

ctgagaaatg tgactccacc caaggtctcc ttgtttgagc catcaaaagc agagattgca     1320

aacaaacaaa aggctaccct cgtgtgcttg gccaggggct tcttccctga ccacgtggag     1380

ctgagctggt gggtgaatgg caaggaggtc cacagtgggg tcagcacgga ccctcaggcc     1440

tacaaggaga gcaattatag ctactgcctg agcagccgcc tgagggtctc tgctaccttc     1500

tggcacaatc ctcgcaacca cttccgctgc caagtgcagt tccacgggct ttcagaggag     1560

gacaagtggc cagagggctc acccaaacct gtcacacaga acatcagtgc agaggcctgg     1620

ggccgagcag actgtgggat tacctcagca tcctatcaac aaggggtctt gtctgccacc     1680

atcctctatg agatcctgct agggaaagcc accctgtatg ctgtgcttgt cagtacactg     1740

gtggtgatgg ctatggtcaa aagaaagaat tcatga                               1776


<210>  37
<211>  172
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR-betta constant region  aa sequence

<400>  37

Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
1               5                   10                  15      


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu 
    50                  55                  60                  


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
65                  70                  75                  80  


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
                85                  90                  95      


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
            100                 105                 110         


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
        115                 120                 125             


Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
    130                 135                 140                 


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Gly 
145                 150                 155                 160 


Leu Val Leu Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170         


<210>  38
<211>  516
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TCR-betta constant region  NA sequence

<400>  38
gatctgagaa atgtgactcc acccaaggtc tccttgtttg agccatcaaa agcagagatt       60

gcaaacaaac aaaaggctac cctcgtgtgc ttggccaggg gcttcttccc tgaccacgtg      120

gagctgagct ggtgggtgaa tggcaaggag gtccacagtg gggtcagcac ggaccctcag      180

gcctacaagg agagcaatta tagctactgc ctgagcagcc gcctgagggt ctctgctacc      240

ttctggcaca atcctcgaaa ccacttccgc tgccaagtgc agttccatgg gctttcggag      300

gaggacaagt ggccagaggg ctcacccaaa cctgtcacac agaacatcag tgcagaggcc      360

tggggccgag cagactgtgg aatcacttca gcatcctatc atcagggggt tctgtctgca      420

accatcctct atgagatcct actggggaag gccaccctat atgctgtgct ggtcagtggc      480

ctggtgctga tggccatggt caagagaaaa aattcc                                516


<210>  39
<211>  66
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD8 Hinge+TM aa sequence

<400>  39

Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr 
1               5                   10                  15      


Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser 
            20                  25                  30          


Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
        35                  40                  45              


Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile Thr 
    50                  55                  60                  


Leu Ile 
65      


<210>  40
<211>  198
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD8 Hinge+TM NA sequence

<400>  40
actactacca agccagtgct gcgaactccc tcacctgtgc accctaccgg gacatctcag       60

ccccagagac cagaagattg tcggccccgt ggctcagtga aggggaccgg attggacttc      120

gcctgtgata tttacatctg ggcacccttg gccggaatct gcgtggccct tctgctgtcc      180

ttgatcatca ctctcatc                                                    198


<210>  41
<211>  382
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FcgRI extracellular-TCRbeta constant region construct  aa 
       sequence

<400>  41

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Gly Ser Thr Arg 
        195                 200                 205             


Pro Arg Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    210                 215                 220                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
225                 230                 235                 240 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                245                 250                 255     


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr 
            260                 265                 270         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        275                 280                 285             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    290                 295                 300                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
305                 310                 315                 320 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                325                 330                 335     


Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile 
            340                 345                 350         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        355                 360                 365             


Ser Gly Leu Val Leu Met Ala Met Val Lys Arg Lys Asn Ser 
    370                 375                 380         


<210>  42
<211>  1146
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FcgRI extracellular-TCRbeta constant region construct  NA 
       sequence

<400>  42
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gaggatccac gcgtccgcgg gatctgagaa atgtgactcc acccaaggtc      660

tccttgtttg agccatcaaa agcagagatt gcaaacaaac aaaaggctac cctcgtgtgc      720

ttggccaggg gcttcttccc tgaccacgtg gagctgagct ggtgggtgaa tggcaaggag      780

gtccacagtg gggtcagcac ggaccctcag gcctacaagg agagcaatta tagctactgc      840

ctgagcagcc gcctgagggt ctctgctacc ttctggcaca atcctcgaaa ccacttccgc      900

tgccaagtgc agttccatgg gctttcggag gaggacaagt ggccagaggg ctcacccaaa      960

cctgtcacac agaacatcag tgcagaggcc tggggccgag cagactgtgg aatcacttca     1020

gcatcctatc atcagggggt tctgtctgca accatcctct atgagatcct actggggaag     1080

gccaccctat atgctgtgct ggtcagtggc ctggtgctga tggccatggt caagagaaaa     1140

aattcc                                                                1146


<210>  43
<211>  405
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FcgRI extracellular-CD8-hinge+TM-Fcrg construct  aa sequence

<400>  43

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Thr Thr Thr Lys Pro Val Leu 
    290                 295                 300                 


Arg Thr Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg 
305                 310                 315                 320 


Pro Glu Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp 
                325                 330                 335     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val 
            340                 345                 350         


Ala Leu Leu Leu Ser Leu Ile Ile Thr Leu Ile Arg Leu Lys Ile Gln 
        355                 360                 365             


Val Arg Lys Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val Tyr 
    370                 375                 380                 


Thr Gly Leu Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys His 
385                 390                 395                 400 


Glu Lys Pro Pro Gln 
                405 


<210>  44
<211>  1218
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FcgRI extracellular-CD8-hinge+TM-Fcrg construct  NA sequence

<400>  44
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tactactacc      900

aagccagtgc tgcgaactcc ctcacctgtg caccctaccg ggacatctca gccccagaga      960

ccagaagatt gtcggccccg tggctcagtg aaggggaccg gattggactt cgcctgtgat     1020

atttacatct gggcaccctt ggccggaatc tgcgtggccc ttctgctgtc cttgatcatc     1080

actctcatcc gactcaagat ccaggtccga aaggcagcta tagccagccg tgagaaagca     1140

gatgctgtct acacgggcct gaacacccgg agccaggaga catatgagac tctgaagcat     1200

gagaaaccac cccagtag                                                   1218


<210>  45
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40 intracellular domain AA sequence

<400>  45

Arg Lys Ala Trp Arg Leu Pro Asn Thr Pro Lys Pro Cys Trp Gly Asn 
1               5                   10                  15      


Ser Phe Arg Thr Pro Ile Gln Glu Glu His Thr Asp Ala His Phe Thr 
            20                  25                  30          


Leu Ala Lys Ile 
        35      


<210>  46
<211>  108
<212>  DNA
<213>  Artificial sequence

<220>
<223>  OX40 intracellular domain NA sequence

<400>  46
cggaaggctt ggagattgcc taacactccc aaaccttgtt ggggaaacag cttcaggacc       60

ccgatccagg aggaacacac agacgcacac tttactctgg ccaagatc                   108


<210>  47
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB intracellular domain AA sequence

<400>  47

Ser Val Leu Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
1               5                   10                  15      


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
            20                  25                  30          


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
        35                  40                  45              


<210>  48
<211>  144
<212>  DNA
<213>  Artificial sequence

<220>
<223>  41BB intracellular domain NA sequence

<400>  48
tctgtgctca aatggatcag gaaaaaattc ccccacatat tcaagcaacc atttaagaag       60

accactggag cagctcaaga ggaagatgct tgtagctgcc gatgtccaca ggaagaagaa      120

ggaggaggag gaggctatga gctg                                             144


<210>  49
<211>  186
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TNFR2 intracellular signaling domain AA SEQUENCE

<400>  49

Lys Lys Lys Pro Ser Cys Leu Gln Arg Asp Ala Lys Val Pro His Val 
1               5                   10                  15      


Pro Asp Glu Lys Ser Gln Asp Ala Val Gly Leu Glu Gln Gln His Leu 
            20                  25                  30          


Leu Thr Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala 
        35                  40                  45              


Ser Ala Gly Asp Arg Arg Ala Pro Pro Gly Gly His Pro Gln Ala Arg 
    50                  55                  60                  


Val Met Ala Glu Ala Gln Gly Phe Gln Glu Ala Arg Ala Ser Ser Arg 
65                  70                  75                  80  


Ile Ser Asp Ser Ser His Gly Ser His Gly Thr His Val Asn Val Thr 
                85                  90                  95      


Cys Ile Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser 
            100                 105                 110         


Ser Gln Ala Ser Ala Thr Val Gly Asp Pro Asp Ala Lys Pro Ser Ala 
        115                 120                 125             


Ser Pro Lys Asp Glu Gln Val Pro Phe Ser Gln Glu Glu Cys Pro Ser 
    130                 135                 140                 


Gln Ser Pro Cys Glu Thr Thr Glu Thr Leu Gln Ser His Glu Lys Pro 
145                 150                 155                 160 


Leu Pro Leu Gly Val Pro Asp Met Gly Met Lys Pro Ser Gln Ala Gly 
                165                 170                 175     


Trp Phe Asp Gln Ile Ala Val Lys Val Ala 
            180                 185     


<210>  50
<211>  558
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TNFR2 intracellular signaling domain NA SEQUENCE

<400>  50
aaaaagaagc cctcctgcct acaaagagat gccaaggtgc ctcatgtgcc tgatgagaaa       60

tcccaggatg cagtaggcct tgagcagcag cacctgttga ccacagcacc cagttccagc      120

agcagctccc tagagagctc agccagcgct ggggaccgaa gggcgccccc tgggggccat      180

ccccaagcaa gagtcatggc ggaggcccaa gggtttcagg aggcccgtgc cagctccagg      240

atttcagatt cttcccacgg aagccacggg acccacgtca acgtcacctg catcgtgaac      300

gtctgtagca gctctgacca cagttctcag tgctcttccc aagccagcgc cacagtggga      360

gacccagatg ccaagccctc agcgtcccca aaggatgagc aggtcccctt ctctcaggag      420

gagtgtccgt ctcagtcccc gtgtgagact acagagacac tgcagagcca tgagaagccc      480

ttgccccttg gtgtgccgga tatgggcatg aagcccagcc aagctggctg gtttgatcag      540

attgcagtca aagtggcc                                                    558


<210>  51
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-12Rb1 intracellular AA SEQUENCE

<400>  51

Asn Arg Ala Ala Trp His Leu Cys Pro Pro Leu Pro Thr Pro Cys Gly 
1               5                   10                  15      


Ser Thr Ala Val Glu Phe Pro Gly Ser Gln Gly Lys Gln Ala Trp Gln 
            20                  25                  30          


Trp Cys Asn Pro Glu Asp Phe Pro Glu Val Leu Tyr Pro Arg Asp Ala 
        35                  40                  45              


Leu Val Val Glu Met Pro Gly Asp Arg Gly Asp Gly Thr Glu Ser Pro 
    50                  55                  60                  


Gln Ala Ala Pro Glu Cys Ala Leu Asp Thr Arg Arg Pro Leu Glu Thr 
65                  70                  75                  80  


Gln Arg Gln Arg Gln Val Gln Ala Leu Ser Glu Ala Arg Arg Leu Gly 
                85                  90                  95      


Leu Ala Arg Glu Asp Cys Pro Arg Gly Asp Leu Ala His Val Thr Leu 
            100                 105                 110         


Pro Leu Leu Leu Gly Gly Val Thr Gln Gly Ala Ser Val Leu Asp Asp 
        115                 120                 125             


Leu Trp Arg Thr His Lys Thr Ala Glu Pro Gly Pro Pro Thr Leu Gly 
    130                 135                 140                 


Gln Glu Ala 
145         


<210>  52
<211>  441
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL-12Rb1 intracellular NA SEQUENCE

<400>  52
aacagggccg cctggcactt gtgcccaccc ctgcctacac cctgtggcag cactgccgtg       60

gagttccctg gcagccaggg caagcaggct tggcagtggt gcaaccctga ggacttcccg      120

gaggtgttgt acccgcgaga tgcgctggtg gtcgagatgc ccggagacag aggcgacggg      180

acagagtcgc cccaggccgc ccctgagtgc gccctggaca caaggcggcc cttggagact      240

cagaggcaga ggcaggtgca ggcactgtca gaggccaggc gcctgggcct ggctagggag      300

gactgtcccc gtggtgacct ggcccacgtg acactcccgc tgctcctggg aggtgtgacc      360

cagggagcct ctgtacttga cgatctttgg aggacccata agactgcgga gccgggaccg      420

cccactttgg ggcaagaggc c                                                441


<210>  53
<211>  216
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-12Rb2 intracellular AA SEQUENCE

<400>  53

Arg Tyr Phe Arg Gln Lys Ala Phe Thr Leu Leu Ser Thr Leu Lys Pro 
1               5                   10                  15      


Gln Trp Tyr Ser Arg Thr Ile Pro Asp Pro Ala Asn Ser Thr Trp Val 
            20                  25                  30          


Lys Lys Tyr Pro Ile Leu Glu Glu Lys Ile Gln Leu Pro Thr Asp Asn 
        35                  40                  45              


Leu Leu Met Ala Trp Pro Thr Pro Glu Glu Pro Glu Pro Leu Ile Ile 
    50                  55                  60                  


His Glu Val Leu Tyr His Met Ile Pro Val Val Arg Gln Pro Tyr Tyr 
65                  70                  75                  80  


Phe Lys Arg Gly Gln Gly Phe Gln Gly Tyr Ser Thr Ser Lys Gln Asp 
                85                  90                  95      


Ala Met Tyr Ile Ala Asn Pro Gln Ala Thr Gly Thr Leu Thr Ala Glu 
            100                 105                 110         


Thr Arg Gln Leu Val Asn Leu Tyr Lys Val Leu Glu Ser Arg Asp Pro 
        115                 120                 125             


Asp Ser Lys Leu Ala Asn Leu Thr Ser Pro Leu Thr Val Thr Pro Val 
    130                 135                 140                 


Asn Tyr Leu Pro Ser His Glu Gly Tyr Leu Pro Ser Asn Ile Glu Asp 
145                 150                 155                 160 


Leu Ser Pro His Glu Ala Asp Pro Thr Asp Ser Phe Asp Leu Glu His 
                165                 170                 175     


Gln His Ile Ser Leu Ser Ile Phe Ala Ser Ser Ser Leu Arg Pro Leu 
            180                 185                 190         


Ile Phe Gly Gly Glu Arg Leu Thr Leu Asp Arg Leu Lys Met Gly Tyr 
        195                 200                 205             


Asp Ser Leu Met Ser Asn Glu Ala 
    210                 215     


<210>  54
<211>  648
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL-12Rb2 intracellular NA SEQUENCE

<400>  54
cgttacttcc ggcaaaaggc atttactctc ctgtctactc tcaaacctca atggtatagc       60

agaaccattc cagatccagc aaacagcact tgggtaaaga agtatcccat tctggaggag      120

aagatccagc tacctacgga taatctcctg atggcatggc ccactcctga agagcctgag      180

cccctgatca tccatgaagt cctctaccac atgatcccag ttgtcagaca accatattac      240

ttcaaaagag gccaaggatt ccaaggctac tctacctcca agcaagatgc aatgtatatt      300

gccaatccac aagctacagg aactctcaca gctgagacca gacagctagt gaacctatac      360

aaggtgctag aaagcagaga ccctgactca aaactggcca acctgaccag ccccttgaca      420

gtcaccccag tgaactacct tcctagccat gaaggctatt taccctccaa catagaagat      480

ctgtcaccac atgaggctga cccaactgat tcttttgacc tggagcatca acatatttct      540

ctttccattt ttgcatcaag ttctctccgc ccactcatct tcggtggtga gcggctgact      600

ctagatcggt taaagatggg ctatgactcc ctcatgagta atgaggct                   648


<210>  55
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-23R intracellular  AA SEQUENCE

<400>  55

Asn Arg Ser Leu Arg Ile Gly Ile Lys Arg Lys Val Leu Leu Met Ile 
1               5                   10                  15      


Pro Lys Trp Leu Tyr Glu Asp Ile Pro Asn Met Glu Asn Ser Asn Val 
            20                  25                  30          


Ala Lys Leu Leu Gln Glu Lys Ser Val Phe Glu Asn Asp Asn Ala Ser 
        35                  40                  45              


Glu Gln Ala Leu Tyr Val Asp Pro Val Leu Thr Glu Ile Ser Glu Ile 
    50                  55                  60                  


Ser Pro Leu Glu His Lys Pro Thr Asp Tyr Lys Glu Glu Arg Leu Thr 
65                  70                  75                  80  


Gly Leu Leu Glu Thr Arg Asp Cys Pro Leu Gly Met Leu Ser Thr Ser 
                85                  90                  95      


Ser Ser Val Val Tyr Ile Pro Asp Leu Asn Thr Gly Tyr Lys Pro Gln 
            100                 105                 110         


Val Ser Asn Val Pro Pro Gly Gly Asn Leu Phe Ile Asn Arg Asp Glu 
        115                 120                 125             


Arg Asp Pro Thr Ser Leu Glu Thr Thr Asp Asp His Phe Ala Arg Leu 
    130                 135                 140                 


Lys Thr Tyr Pro Asn Phe Gln Phe Ser Ala Ser Ser Met Ala Leu Leu 
145                 150                 155                 160 


Asn Lys Thr Leu Ile Leu Asp Glu Leu Cys Leu Val Leu Asn Gln Gly 
                165                 170                 175     


Glu Phe Asn Ser Leu Asp Ile Lys Asn Ser Arg Gln Glu Glu Thr Ser 
            180                 185                 190         


Ile Val Leu Gln Ser Asp Ser Pro Ser Glu Thr Ile Pro Ala Gln Thr 
        195                 200                 205             


Leu Leu Ser Asp Glu Phe Val Ser Cys Leu Ala Ile Gly Asn Glu Asp 
    210                 215                 220                 


Leu Pro Ser Ile Asn Ser Tyr Phe Pro Gln Asn Val Leu Glu Ser His 
225                 230                 235                 240 


Phe Ser Arg Ile Ser Leu Phe Gln Lys 
                245                 


<210>  56
<211>  747
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL-23R intracellular  NA SEQUENCE

<400>  56
aacagatcac ttcgaatagg aattaaaaga aaagttttac tgatgatccc aaagtggctt       60

tatgaagata ttcctaatat ggaaaatagc aatgttgcaa aattattaca ggaaaaaagt      120

gtatttgaga atgataatgc cagtgagcag gccctgtatg tggatcctgt ccttacagag      180

ataagtgaaa tctctcccct ggaacacaaa cccacagatt acaaagaaga aaggctcaca      240

ggactccttg agacaagaga ctgtcctcta ggaatgttgt ctaccagttc ttctgttgtg      300

tatattcctg acctcaacac tggatacaaa ccccaggttt caaatgttcc tcctggagga      360

aaccttttca ttaacagaga tgaaagagac cctacatccc ttgagaccac agatgaccac      420

tttgccagat tgaaaacata tcccaacttc caattttctg cttcaagtat ggctttacta      480

aacaaaacac taattcttga tgaattgtgc ctcgttttaa atcaaggaga gttcaattct      540

cttgacataa aaaactcaag acaggaggaa accagcatcg ttttgcaaag tgactcaccc      600

agtgaaacta tcccagcgca gactctgttg tctgatgaat ttgtctcctg tttggcaatt      660

gggaatgaag acttgccatc tattaattct tactttccac agaacgtttt ggaaagccat      720

ttcagtagaa tttcactctt ccaaaag                                          747


<210>  57
<211>  202
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IFNgR1 intracellular AA SEQUENCE

<400>  57

Trp Tyr Thr Lys Asn Asn Ser Phe Lys Arg Lys Ser Ile Met Leu Pro 
1               5                   10                  15      


Lys Ser Leu Leu Ser Val Val Lys Ser Ala Thr Leu Glu Thr Lys Pro 
            20                  25                  30          


Glu Ser Lys Tyr Ser Leu Val Thr Pro His Gln Pro Ala Val Leu Glu 
        35                  40                  45              


Ser Glu Thr Val Ile Cys Glu Glu Pro Leu Ser Thr Val Thr Ala Pro 
    50                  55                  60                  


Asp Ser Pro Glu Ala Ala Glu Gln Glu Glu Leu Ser Lys Glu Thr Lys 
65                  70                  75                  80  


Ala Leu Glu Ala Gly Gly Ser Thr Ser Ala Met Thr Pro Asp Ser Pro 
                85                  90                  95      


Pro Thr Pro Thr Gln Arg Arg Ser Phe Ser Leu Leu Ser Ser Asn Gln 
            100                 105                 110         


Ser Gly Pro Cys Ser Leu Thr Ala Tyr His Ser Arg Asn Gly Ser Asp 
        115                 120                 125             


Ser Gly Leu Val Gly Ser Gly Ser Ser Ile Ser Asp Leu Glu Ser Leu 
    130                 135                 140                 


Pro Asn Asn Asn Ser Glu Thr Lys Met Ala Glu His Asp Pro Pro Pro 
145                 150                 155                 160 


Val Arg Lys Ala Pro Met Ala Ser Gly Tyr Asp Lys Pro His Met Leu 
                165                 170                 175     


Val Asp Val Leu Val Asp Val Gly Gly Lys Glu Ser Leu Met Gly Tyr 
            180                 185                 190         


Arg Leu Thr Gly Glu Ala Gln Glu Leu Ser 
        195                 200         


<210>  58
<211>  606
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IFNgR1 intracellular NA SEQUENCE

<400>  58
tggtatacta agaacaattc attcaagaga aaaagcataa tgttacctaa gtccttgctc       60

tctgtggtaa aaagtgccac gttagagaca aaacctgaat cgaagtattc acttgtcaca      120

ccgcaccagc cagctgtcct agagagtgag acggtgatct gtgaagagcc cctgtccaca      180

gtgacagctc cagacagccc cgaagcagca gaacaggaag aactttcaaa agaaacaaag      240

gctctggagg ctggaggaag cacgtctgcc atgaccccag acagccctcc aactccgaca      300

caaagacgca gcttttccct gttaagtagt aaccagtcag gcccttgtag cctcaccgcc      360

tatcactccc gaaacggctc tgacagtggc ctcgtgggat cgggcagctc catatcggac      420

ttggaatctc tcccaaacaa caactcagaa acaaagatgg cagagcacga ccctccaccc      480

gtgagaaagg cccccatggc ctccggttat gacaaaccgc acatgttggt ggacgtgctt      540

gtggatgttg gggggaagga gtctctcatg gggtatagac tcacaggaga ggcccaggag      600

ctgtcc                                                                 606


<210>  59
<211>  67
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IFNgR2 intracellular AA SEQUENCE

<400>  59

Leu Lys Tyr Gln Ser Arg Val Lys Tyr Trp Phe Gln Ala Pro Pro Asn 
1               5                   10                  15      


Ile Pro Glu Gln Ile Glu Glu Tyr Leu Lys Asp Pro Asp Gln Phe Ile 
            20                  25                  30          


Leu Glu Val Leu Asp Lys Asp Gly Ser Pro Lys Glu Asp Ser Trp Asp 
        35                  40                  45              


Ser Val Ser Ile Ile Ser Ser Pro Glu Lys Glu Arg Asp Asp Val Leu 
    50                  55                  60                  


Gln Thr Pro 
65          


<210>  60
<211>  201
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IFNgR2 intracellular NA SEQUENCE

<400>  60
ctcaaatacc aaagccgagt gaagtactgg tttcaggctc cgccaaacat cccggaacaa       60

atcgaagagt atctaaagga cccagaccaa ttcatcttag aggtcttgga caaggacggt      120

tcaccgaagg aggactcctg ggactccgtg tcaattattt cttctccaga aaaggagcga      180

gatgatgtgc tccaaacacc g                                                201


<210>  61
<211>  271
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-2Rb intracellular AA SEQUENCE

<400>  61

Lys Cys Arg Tyr Leu Gly Pro Trp Leu Lys Thr Val Leu Lys Cys His 
1               5                   10                  15      


Ile Pro Asp Pro Ser Glu Phe Phe Ser Gln Leu Ser Ser Gln His Gly 
            20                  25                  30          


Gly Asp Leu Gln Lys Trp Leu Ser Ser Pro Val Pro Leu Ser Phe Phe 
        35                  40                  45              


Ser Pro Ser Gly Pro Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Asp 
    50                  55                  60                  


Gly Asp Ser Lys Ala Val Gln Leu Leu Leu Leu Gln Lys Asp Ser Ala 
65                  70                  75                  80  


Pro Leu Pro Ser Pro Ser Gly His Ser Gln Ala Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asn Ala Leu Glu Ile Glu Ser 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Cys Val Glu Glu Glu Val Glu 
        115                 120                 125             


Glu Asp Gly Ser Arg Leu Pro Glu Gly Ser Pro His Pro Pro Leu Leu 
    130                 135                 140                 


Pro Leu Ala Gly Glu Gln Asp Asp Tyr Cys Ala Phe Pro Pro Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Ser Thr Pro Asn Thr Ala Tyr 
                165                 170                 175     


Gly Gly Ser Arg Ala Pro Glu Glu Arg Ser Pro Leu Ser Leu His Glu 
            180                 185                 190         


Gly Leu Pro Ser Leu Ala Ser Arg Asp Leu Met Gly Leu Gln Arg Pro 
        195                 200                 205             


Leu Glu Arg Met Pro Glu Gly Asp Gly Glu Gly Leu Ser Ala Asn Ser 
    210                 215                 220                 


Ser Gly Glu Gln Ala Ser Val Pro Glu Gly Asn Leu His Gly Gln Asp 
225                 230                 235                 240 


Gln Asp Arg Gly Gln Gly Pro Ile Leu Thr Leu Asn Thr Asp Ala Tyr 
                245                 250                 255     


Leu Ser Leu Gln Glu Leu Gln Ala Gln Asp Ser Val His Leu Ile 
            260                 265                 270     


<210>  62
<211>  813
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL-2Rb intracellular NA SEQUENCE

<400>  62
aagtgccggt accttgggcc atggctgaag acagttctca agtgccacat cccagatcct       60

tctgagttct tctcccagct gagctcccag catgggggag accttcagaa atggctctcc      120

tcgcctgtcc ccttgtcctt cttcagcccc agtggccctg cccctgagat ctctccgctg      180

gaagtgctcg acggagattc caaggccgtg cagctgctcc tgttacagaa ggactctgcc      240

cctttaccct cgcccagcgg ccactcacag gccagctgct tcaccaacca gggctacttc      300

ttcttccatc tgcccaatgc cttggagatc gaatcctgcc aggtgtactt cacctatgac      360

ccctgtgtgg aagaggaggt ggaggaggat gggtcaaggc tgcccgaggg atctccccac      420

ccacctctgc tgcctctggc tggagaacag gatgactact gtgccttccc gcccagggat      480

gacctgctgc tcttctcccc gagcctcagc acccccaaca ctgcctatgg gggcagcaga      540

gcccctgaag aaagatctcc actctccctg catgagggac ttccctccct agcatcccgt      600

gacctgatgg gcttacagcg ccctctggag cggatgccgg aaggtgatgg agaggggctg      660

tctgccaata gctctgggga gcaggccagt gtcccagaag gcaaccttca tgggcaagat      720

caggacagag gccagggccc catcctgacc ctgaacaccg atgcctatct gtctcttcaa      780

gaactacagg cccaagattc agtccaccta ata                                   813


<210>  63
<211>  85
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-2R common gamma intracellular AA sequence

<400>  63

Glu Arg Met Pro Pro Ile Pro Pro Ile Lys Asn Leu Glu Asp Leu Val 
1               5                   10                  15      


Thr Glu Tyr Gln Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly 
            20                  25                  30          


Leu Thr Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Phe Cys His Val 
        35                  40                  45              


Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Gly 
    50                  55                  60                  


Ser Pro Cys Ser Leu His Ser Pro Tyr Trp Pro Pro Pro Cys Tyr Ser 
65                  70                  75                  80  


Leu Lys Pro Glu Ala 
                85  


<210>  64
<211>  255
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL-2R common gamma intracellular NA sequence

<400>  64
gaacgaatgc ctccaattcc ccccatcaag aatctagagg atctggttac tgaataccaa       60

gggaactttt cggcctggag tggtgtgtct aaagggctga ctgagagtct gcagccagac      120

tacagtgaac ggttctgcca cgtcagcgag attcccccca aaggaggggc cctaggagag      180

gggcctggag gttctccttg cagcctgcat agcccttact ggcctccccc atgttattct      240

ctgaagccgg aagcc                                                       255


<210>  65
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-1R1 intracellular AA sequence

<400>  65

Lys Val Phe Lys Val Asp Ile Val Leu Trp Tyr Arg Asp Ser Cys Ser 
1               5                   10                  15      


Gly Phe Leu Pro Ser Lys Ala Ser Asp Gly Lys Thr Tyr Asp Ala Tyr 
            20                  25                  30          


Ile Leu Tyr Pro Lys Thr Leu Gly Glu Gly Ser Phe Ser Asp Leu Asp 
        35                  40                  45              


Thr Phe Val Phe Lys Leu Leu Pro Glu Val Leu Glu Gly Gln Phe Gly 
    50                  55                  60                  


Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val Gly Glu Asp Thr 
65                  70                  75                  80  


Ile Glu Val Thr Asn Glu Asn Val Lys Lys Ser Arg Arg Leu Ile Ile 
                85                  90                  95      


Ile Leu Val Arg Asp Met Gly Gly Phe Ser Trp Leu Gly Gln Ser Ser 
            100                 105                 110         


Glu Glu Gln Ile Ala Ile Tyr Asn Ala Leu Ile Gln Glu Gly Ile Lys 
        115                 120                 125             


Ile Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr Glu Lys Met Pro 
    130                 135                 140                 


Asp Ser Ile Gln Phe Ile Lys Gln Lys His Gly Val Ile Cys Trp Ser 
145                 150                 155                 160 


Gly Asp Phe Gln Glu Arg Pro Gln Ser Ala Lys Thr Arg Phe Trp Lys 
                165                 170                 175     


Asn Leu Arg Tyr Gln Met Pro Ala Gln Arg Arg Ser Pro Leu Ser Lys 
            180                 185                 190         


His Arg Leu Leu Thr Leu Asp Pro Val Arg Asp Thr Lys Glu Lys Leu 
        195                 200                 205             


Pro Ala Ala Thr His Leu Pro Leu Gly 
    210                 215         


<210>  66
<211>  651
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL-1R1 intracellular NA sequence

<400>  66
aaagtcttca aggttgacat agtgctttgg tacagggact cctgctctgg ttttcttcct       60

tcaaaagctt cagatggaaa gacatacgat gcctatattc tttatcccaa gaccctggga      120

gaggggtcct tctcagactt agatactttt gtttttaaac tgttgcctga ggtcttggag      180

ggacagtttg gatacaagct gttcatttat ggaagggatg actatgttgg agaagatacc      240

atcgaggtta ctaatgaaaa tgtaaagaaa agcaggaggc tgattatcat tctagtgaga      300

gatatgggag gcttcagctg gctgggccag tcatctgaag agcaaatagc catatacaat      360

gctctcatcc aggaaggaat taaaatcgtc ctgcttgagt tggagaaaat ccaagactat      420

gagaaaatgc cagattctat tcagttcatt aagcagaaac acggagtcat ttgctggtca      480

ggagactttc aagaaagacc acagtctgca aagaccaggt tctggaaaaa cttaagatac      540

cagatgccag cccaacggag atcaccattg tctaaacacc gcttactaac cctggatcct      600

gtgcgggaca ctaaggagaa actgccggca gcaacacact taccactcgg c               651


<210>  67
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-1AcP intracellular AA sequence

<400>  67

Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu Asp Gly Lys Glu 
1               5                   10                  15      


Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Val Glu Glu Glu Glu Phe 
            20                  25                  30          


Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu Phe Gly Tyr Lys 
        35                  40                  45              


Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly Ile Val Thr Asp 
    50                  55                  60                  


Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu Leu Val Val Leu 
65                  70                  75                  80  


Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu Leu Glu Leu Lys 
                85                  90                  95      


Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile Asn Val Ile Leu 
            100                 105                 110         


Val Gln Tyr Lys Ala Val Lys Asp Met Lys Val Lys Glu Leu Lys Arg 
        115                 120                 125             


Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly Glu Lys Ser Lys 
    130                 135                 140                 


Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val Ala Met Pro Val 
145                 150                 155                 160 


Lys Lys Ser Pro Arg Trp Ser Ser Asn Asp Lys Gln Gly Leu Ser Tyr 
                165                 170                 175     


Ser Ser Leu Lys Asn Val 
            180         


<210>  68
<211>  546
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL-1AcP intracellular NA sequence

<400>  68
taccgagctc actttggaac agatgaaaca attcttgatg gaaaggagta tgatatttat       60

gtttcctatg caagaaatgt ggaagaagag gaatttgtgc tgctgacgct gcgtggagtt      120

ttggagaatg agtttggata caagctgtgc atcttcgaca gagacagcct gcctggggga      180

attgtcacag atgagaccct gagcttcatt cagaaaagca gacgactcct ggttgtccta      240

agtcccaact acgtgctcca gggaacacaa gccctcctgg agctcaaggc tggcctagaa      300

aatatggcct cacggggcaa catcaacgtc attttagtgc agtacaaagc tgtgaaggac      360

atgaaggtga aagagctgaa gcgggctaag acggtgctca cggtcattaa atggaaagga      420

gagaaatcca agtatcctca gggcaggttc tggaagcagt tgcaggtggc catgccagtg      480

aagaagagtc ccaggtggtc tagcaatgac aagcagggtc tctcctactc atccctgaaa      540

aacgta                                                                 546


