                         SEQUENCE LISTING

<110>  BIO-RAD ABD SEROTEC GMBH
 
<120>  ANTIGEN BINDING FRAGMENTS CONJUGATED TO A PLURALITY OF FC 
       ISOTYPES AND SUBCLASSES

<130>  BRL.123XC1PCT

<150>  US 62/819,748
<151>  2019-03-18

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  340
<212>  PRT
<213>  Streptococcus pyogenes

<400>  1

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr 
        115                 120                 125             


Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu 
    130                 135                 140                 


Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser 
145                 150                 155                 160 


Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr 
                165                 170                 175     


Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe 
            180                 185                 190         


Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu 
        195                 200                 205             


Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln 
    210                 215                 220                 


Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly 
225                 230                 235                 240 


Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val 
                245                 250                 255     


Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val 
            260                 265                 270         


Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu 
        275                 280                 285             


Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys 
    290                 295                 300                 


Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr 
305                 310                 315                 320 


Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys 
                325                 330                 335     


Lys Lys Asn Ala 
            340 


<210>  2
<211>  1023
<212>  DNA
<213>  Streptococcus pyogenes

<400>  2
atgaaattac gtcacttact attaacggga gcagccctaa ctagttttgc tgctacaaca       60

gttcacgggg agactgttgt aaacggagcc aaactaacag ttacaaaaaa ccttgattta      120

gttaatagca atgcattaat tccaaataca gattttacat ttaaaatcga acctgatact      180

actgtcaacg aagacggaaa taagtttaaa ggtgtagctt tgaacacacc gatgactaaa      240

gtcacttaca ccaattcaga taaaggtgga tcaaatacga aaactgcaga atttgatttt      300

tcagaagtta cttttgaaaa accaggtgtt tattattaca aagtaactga ggagaagata      360

gataaagttc ctggtgtttc ttatgataca acatcttaca ctgttcaagt tcatgtcttg      420

tggaatgaag agcaacaaaa accagtagct acttatattg ttggttataa agaaggtagt      480

aaggtgccaa ttcagttcaa aaatagctta gattctacta cattaacggt gaagaaaaaa      540

gtttcaggta ccggtggaga tcgctctaaa gattttaatt ttggtctgac tttaaaagca      600

aatcagtatt ataaggcgtc agaaaaagtc atgattgaga agacaactaa aggtggtcaa      660

gctcctgttc aaacagaggc tagtatagat caactctatc attttacctt gaaagatggt      720

gaatcaatca aagtcacaaa tcttccagta ggtgtggatt atgttgtcac tgaagacgat      780

tacaaatcag aaaaatatac aaccaacgtg gaagttagtc ctcaagatgg agctgtaaaa      840

aatatcgcag gtaattcaac tgaacaagag acatctactg ataaagatat gaccattact      900

tttacaaata aaaaagactt tgaagtgcca acaggagtag caatgactgt ggcaccatat      960

attgctttag gaattgtagc agttggtgga gctctttact ttgttaaaaa gaaaaatgct     1020

taa                                                                   1023


<210>  3
<211>  674
<212>  PRT
<213>  Enterococcus faecalis

<400>  3

Met Thr Lys Ser Val Lys Phe Leu Val Leu Leu Leu Val Met Ile Leu 
1               5                   10                  15      


Pro Ile Ala Gly Ala Leu Leu Ile Gly Pro Ile Ser Phe Gly Ala Glu 
            20                  25                  30          


Leu Ser Lys Ser Ser Ile Val Asp Lys Val Glu Leu Asp His Thr Thr 
        35                  40                  45              


Leu Tyr Gln Gly Glu Met Thr Ser Ile Lys Val Ser Phe Ser Asp Lys 
    50                  55                  60                  


Glu Asn Gln Lys Ile Lys Pro Gly Asp Thr Ile Thr Leu Thr Leu Pro 
65                  70                  75                  80  


Asp Ala Leu Val Gly Met Thr Glu Asn Asp Ser Ser Pro Arg Lys Ile 
                85                  90                  95      


Asn Leu Asn Gly Leu Gly Glu Val Phe Ile Tyr Lys Asp His Val Val 
            100                 105                 110         


Ala Thr Phe Asn Glu Lys Val Glu Ser Leu His Asn Val Asn Gly His 
        115                 120                 125             


Phe Ser Phe Gly Ile Lys Thr Leu Ile Thr Asn Ser Ser Gln Pro Asn 
    130                 135                 140                 


Val Ile Glu Thr Asp Phe Gly Thr Ala Thr Ala Thr Gln Arg Leu Thr 
145                 150                 155                 160 


Ile Glu Gly Val Thr Asn Thr Glu Thr Gly Gln Ile Glu Arg Asp Tyr 
                165                 170                 175     


Pro Phe Phe Tyr Lys Val Gly Asp Leu Ala Gly Glu Ser Asn Gln Val 
            180                 185                 190         


Arg Trp Phe Leu Asn Val Asn Leu Asn Lys Ser Asp Val Thr Glu Asp 
        195                 200                 205             


Ile Ser Ile Ala Asp Arg Gln Gly Ser Gly Gln Gln Leu Asn Lys Glu 
    210                 215                 220                 


Ser Phe Thr Phe Asp Ile Val Asn Asp Lys Glu Thr Lys Tyr Ile Ser 
225                 230                 235                 240 


Leu Ala Glu Phe Glu Gln Gln Gly Tyr Gly Lys Ile Asp Phe Val Thr 
                245                 250                 255     


Asp Asn Asp Phe Asn Leu Arg Phe Tyr Arg Asp Lys Ala Arg Phe Thr 
            260                 265                 270         


Ser Phe Ile Val Arg Tyr Thr Ser Thr Ile Thr Glu Ala Gly Gln His 
        275                 280                 285             


Gln Ala Thr Phe Glu Asn Ser Tyr Asp Ile Asn Tyr Gln Leu Asn Asn 
    290                 295                 300                 


Gln Asp Ala Thr Asn Glu Lys Asn Thr Ser Gln Val Lys Asn Val Phe 
305                 310                 315                 320 


Val Glu Gly Glu Ala Ser Gly Asn Gln Asn Val Glu Met Pro Thr Glu 
                325                 330                 335     


Glu Ser Leu Asp Ile Pro Leu Glu Thr Ile Asp Glu Trp Glu Pro Lys 
            340                 345                 350         


Thr Pro Thr Ser Glu Gln Ala Thr Glu Thr Ser Glu Lys Thr Asp Thr 
        355                 360                 365             


Thr Glu Thr Ala Glu Ser Ser Gln Pro Glu Val His Val Ser Pro Thr 
    370                 375                 380                 


Glu Glu Glu Asn Pro Asp Glu Gly Glu Thr Leu Gly Thr Ile Glu Pro 
385                 390                 395                 400 


Ile Ile Pro Glu Lys Pro Ser Val Thr Thr Glu Glu Asn Gly Thr Thr 
                405                 410                 415     


Glu Thr Ala Glu Ser Ser Gln Pro Glu Val His Val Ser Pro Thr Glu 
            420                 425                 430         


Glu Glu Asn Pro Asp Glu Ser Glu Thr Leu Gly Thr Ile Glu Pro Ile 
        435                 440                 445             


Ile Pro Glu Lys Pro Ser Val Thr Thr Glu Glu Asn Gly Thr Thr Glu 
    450                 455                 460                 


Thr Ala Glu Ser Ser Gln Pro Glu Val His Val Ser Pro Ala Glu Glu 
465                 470                 475                 480 


Glu Asn Pro Asp Glu Ser Glu Thr Leu Gly Thr Ile Leu Pro Ile Leu 
                485                 490                 495     


Pro Glu Lys Pro Ser Val Thr Thr Glu Glu Asn Gly Thr Thr Glu Thr 
            500                 505                 510         


Ala Glu Ser Ser Gln Pro Glu Val His Val Ser Pro Thr Glu Glu Glu 
        515                 520                 525             


Asn Pro Asp Glu Ser Glu Thr Leu Gly Thr Ile Ala Pro Ile Ile Pro 
    530                 535                 540                 


Glu Lys Pro Ser Val Thr Thr Glu Glu Asn Gly Ile Thr Glu Thr Ala 
545                 550                 555                 560 


Glu Ser Ser Gln Pro Glu Val His Val Ser Pro Thr Lys Glu Ile Thr 
                565                 570                 575     


Thr Thr Glu Lys Lys Gln Pro Ser Thr Glu Thr Thr Val Glu Lys Asn 
            580                 585                 590         


Lys Asn Val Thr Ser Lys Asn Gln Pro Gln Ile Leu Asn Ala Pro Leu 
        595                 600                 605             


Asn Thr Leu Lys Asn Glu Gly Ser Pro Gln Leu Ala Pro Gln Leu Leu 
    610                 615                 620                 


Ser Glu Pro Ile Gln Lys Leu Asn Glu Ala Asn Gly Gln Arg Glu Leu 
625                 630                 635                 640 


Pro Lys Thr Gly Thr Thr Lys Thr Pro Phe Met Leu Ile Ala Gly Ile 
                645                 650                 655     


Leu Ala Ser Thr Phe Ala Val Leu Gly Val Ser Tyr Leu Gln Ile Arg 
            660                 665                 670         


Lys Asn 
        


<210>  4
<211>  2025
<212>  DNA
<213>  Enterococcus faecalis

<400>  4
atgacaaaaa gtgtaaaatt tttagtgtta ctgttggtaa tgattctacc aattgcgggg       60

gcgttattga ttggtccaat ttcgtttggc gccgaattga gcaaaagttc aatcgttgac      120

aaagtagaat tagatcacac tactttatat caaggagaga tgacctcaat taaagtatct      180

tttagtgaca aagaaaatca gaaaataaaa cctggagata ctattacttt aactttacca      240

gacgcactag ttggaatgac cgagaacgat agttcaccac gaaaaatcaa tttaaatggt      300

ttaggggaag tttttatcta taaagatcat gttgtagcaa catttaacga aaaagttgaa      360

tctttacata atgtgaatgg gcatttttct ttcgggatta aaacgcttat caccaatagt      420

tctcaaccga atgtgataga aacggatttc ggaacagcaa cggcgactca acgtttgacg      480

attgaaggag tgactaacac agagactggc caaattgagc gagactatcc gtttttttat      540

aaagtaggcg atttggctgg agagtcaaat caagtacgtt ggtttttaaa tgtgaacctc      600

aataaatccg atgtcacaga agatatttca attgcggatc gacaaggaag tggtcaacaa      660

ttaaataaag agagttttac atttgatatt gtgaatgaca aagaaactaa atatatttca      720

cttgccgagt ttgagcaaca aggttatggc aaaattgact tcgtaacaga taatgacttt      780

aacttacgtt tttatcggga taaagcacgc tttacttcct ttatcgtccg ttacacttcg      840

acaatcacag aagcaggcca acatcaagca acatttgaaa atagttatga catcaattat      900

caactaaaca atcaagacgc aacgaatgaa aaaaatacat cacaggttaa aaatgttttt      960

gtagaaggcg aggcaagcgg caatcaaaat gtggaaatgc caacagaaga aagtctagac     1020

attcctttag agacaataga tgaatgggaa ccaaagacac ctacttcgga acaggcaaca     1080

gaaacaagtg aaaagacaga cacaacagaa accgcagaaa gcagccaacc agaagttcat     1140

gtctcaccaa cagaagaaga aaatccagat gaaggtgaaa cactaggcac gattgagcca     1200

atcatacctg aaaaaccaag tgtgacaact gaagagaatg gcacgacaga aactgcagaa     1260

agcagccaac cagaagttca tgtctcacca acagaagaag aaaatccaga tgaaagtgaa     1320

acactaggca cgattgagcc aatcatacct gaaaaaccaa gtgtgacaac tgaagagaac     1380

ggcacaacag aaaccgcaga aagcagccaa ccagaagttc atgtctcacc agcggaagaa     1440

gaaaatccag atgaaagtga aacgttaggt acaattttac caatcctacc tgaaaaacca     1500

agtgtgacaa ctgaagagaa tggcacaacg gaaactgcag aaagcagtca accagaagtc     1560

catgtgtcgc caacggaaga agaaaatcca gatgaaagtg aaacactagg cacgattgca     1620

ccaatcatac ctgaaaaacc aagcgtaaca actgaagaga atggtataac ggaaacggca     1680

gaaagcagcc agccagaagt tcatgtctca ccaacaaaag aaattactac aactgagaaa     1740

aaacagccat ccacagaaac aactgtggag aaaaataaaa atgttacatc aaaaaatcaa     1800

ccacaaatac taaacgctcc attaaataca ttgaaaaatg aaggaagccc acagttggct     1860

ccccaactgc ttagtgaacc aattcaaaaa ttaaatgaag caaacgggca acgagaactt     1920

cccaaaacag gcacaacaaa aacaccgttt atgctaatag caggaatact ggcaagtaca     1980

tttgccgttt taggtgtaag ttatctacaa atcagaaaga attaa                     2025


<210>  5
<211>  303
<212>  PRT
<213>  Staphylococcus aureus

<400>  5

Gly Ser Ala Arg Asp Ile Ser Ser Thr Asn Val Thr Asp Leu Thr Val 
1               5                   10                  15      


Ser Pro Ser Lys Ile Glu Asp Gly Gly Lys Thr Thr Val Lys Met Thr 
            20                  25                  30          


Phe Asp Asp Lys Asn Gly Lys Ile Gln Asn Gly Asp Met Ile Lys Val 
        35                  40                  45              


Ala Trp Pro Thr Ser Gly Thr Val Lys Ile Glu Gly Tyr Ser Lys Thr 
    50                  55                  60                  


Val Pro Leu Thr Val Lys Gly Glu Gln Val Gly Gln Ala Val Ile Thr 
65                  70                  75                  80  


Pro Asp Gly Ala Thr Ile Thr Phe Asn Asp Lys Val Glu Lys Leu Ser 
                85                  90                  95      


Asp Val Ser Gly Phe Ala Glu Phe Glu Val Gln Gly Arg Asn Leu Thr 
            100                 105                 110         


Gln Thr Asn Thr Ser Asp Asp Lys Val Ala Thr Ile Thr Ser Gly Asn 
        115                 120                 125             


Lys Ser Thr Asn Val Thr Val His Lys Ser Glu Ala Gly Thr Ser Ser 
    130                 135                 140                 


Val Phe Tyr Tyr Lys Thr Gly Asp Met Leu Pro Glu Asp Thr Thr His 
145                 150                 155                 160 


Val Arg Trp Phe Leu Asn Ile Asn Asn Glu Lys Ser Tyr Val Ser Lys 
                165                 170                 175     


Asp Ile Thr Ile Lys Asp Gln Ile Gln Gly Gly Gln Gln Leu Asp Leu 
            180                 185                 190         


Ser Thr Leu Asn Ile Asn Val Thr Gly Thr His Ser Asn Tyr Tyr Ser 
        195                 200                 205             


Gly Gln Ser Ala Ile Thr Asp Phe Glu Lys Ala Phe Pro Gly Ser Lys 
    210                 215                 220                 


Ile Thr Val Asp Asn Thr Lys Asn Thr Ile Asp Val Thr Ile Pro Gln 
225                 230                 235                 240 


Gly Tyr Gly Ser Tyr Asn Ser Phe Ser Ile Asn Tyr Lys Thr Lys Ile 
                245                 250                 255     


Thr Asn Glu Gln Gln Lys Glu Phe Val Asn Asn Ser Gln Ala Trp Tyr 
            260                 265                 270         


Gln Glu His Gly Lys Glu Glu Val Asn Gly Lys Ser Phe Asn His Thr 
        275                 280                 285             


Val His Asn Ile Asn Ala Asn Ala Gly Ile Glu Gly Thr Val Lys 
    290                 295                 300             


<210>  6
<211>  102
<212>  PRT
<213>  Streptococcus pyogenes

<400>  6

Met Thr Ile Glu Glu Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg 
1               5                   10                  15      


Asp Ile Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp 
            20                  25                  30          


Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val Lys 
        35                  40                  45              


Asp Phe Tyr Leu Met Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala 
    50                  55                  60                  


Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu 
65                  70                  75                  80  


Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala His 
                85                  90                  95      


Ile Val Met Val Asp Ala 
            100         


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpyTag

<400>  7

Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
1               5                   10              


<210>  8
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpyCatcher

<400>  8

Asp Tyr Asp Ile Pro Thr Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met 
1               5                   10                  15      


Val Asp Thr Leu Ser Gly Leu Ser Ser Glu Gln Gly Gln Ser Gly Asp 
            20                  25                  30          


Met Thr Ile Glu Glu Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg 
        35                  40                  45              


Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp 
    50                  55                  60                  


Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val Lys 
65                  70                  75                  80  


Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala 
                85                  90                  95      


Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu 
            100                 105                 110         


Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala His 
        115                 120                 125             


Ile 
    


<210>  9
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpyCatcher (short)

<400>  9

Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg Asp Glu Asp Gly 
1               5                   10                  15      


Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser Ser Gly Lys 
            20                  25                  30          


Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val Lys Asp Phe Tyr Leu 
        35                  40                  45              


Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala Pro Asp Gly Tyr 
    50                  55                  60                  


Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu Gln Gly Gln Val 
65                  70                  75                  80  


Thr Val Asn Gly 
                


<210>  10
<211>  331
<212>  PRT
<213>  Staphylococcus aureus

<400>  10

Met Asn Lys Asn Val Leu Lys Phe Met Val Phe Ile Met Leu Leu Asn 
1               5                   10                  15      


Ile Ile Thr Pro Leu Phe Asn Lys Asn Glu Ala Phe Ala Ala Arg Asp 
            20                  25                  30          


Ile Ser Ser Thr Asn Val Thr Asp Leu Thr Val Ser Pro Ser Lys Ile 
        35                  40                  45              


Glu Asp Gly Gly Lys Thr Thr Val Lys Met Thr Phe Asp Asp Lys Asn 
    50                  55                  60                  


Gly Lys Ile Gln Asn Gly Asp Met Ile Lys Val Ala Trp Pro Thr Ser 
65                  70                  75                  80  


Gly Thr Val Lys Ile Glu Gly Tyr Ser Lys Thr Val Pro Leu Thr Val 
                85                  90                  95      


Lys Gly Glu Gln Val Gly Gln Ala Val Ile Thr Pro Asp Gly Ala Thr 
            100                 105                 110         


Ile Thr Phe Asn Asp Lys Val Glu Lys Leu Ser Asp Val Ser Gly Phe 
        115                 120                 125             


Ala Glu Phe Glu Val Gln Gly Arg Asn Leu Thr Gln Thr Asn Thr Ser 
    130                 135                 140                 


Asp Asp Lys Val Ala Thr Ile Thr Ser Gly Asn Lys Ser Thr Asn Val 
145                 150                 155                 160 


Thr Val His Lys Ser Glu Ala Gly Thr Ser Ser Val Phe Tyr Tyr Lys 
                165                 170                 175     


Thr Gly Asp Met Leu Pro Glu Asp Thr Thr His Val Arg Trp Phe Leu 
            180                 185                 190         


Asn Ile Asn Asn Glu Lys Ser Tyr Val Ser Lys Asp Ile Thr Ile Lys 
        195                 200                 205             


Asp Gln Ile Gln Gly Gly Gln Gln Leu Asp Leu Ser Thr Leu Asn Ile 
    210                 215                 220                 


Asn Val Thr Gly Thr His Ser Asn Tyr Tyr Ser Gly Gln Ser Ala Ile 
225                 230                 235                 240 


Thr Asp Phe Glu Lys Ala Phe Pro Gly Ser Lys Ile Thr Val Asp Asn 
                245                 250                 255     


Thr Lys Asn Thr Ile Asp Val Thr Ile Pro Gln Gly Tyr Gly Ser Tyr 
            260                 265                 270         


Asn Ser Phe Ser Ile Asn Tyr Lys Thr Lys Ile Thr Asn Glu Gln Gln 
        275                 280                 285             


Lys Glu Phe Val Asn Asn Ser Gln Ala Trp Tyr Gln Glu His Gly Lys 
    290                 295                 300                 


Glu Glu Val Asn Gly Lys Ser Phe Asn His Thr Val His Asn Ile Asn 
305                 310                 315                 320 


Ala Asn Ala Gly Ile Glu Gly Thr Val Lys Gly 
                325                 330     


<210>  11
<211>  102
<212>  PRT
<213>  Streptococcus pyogenes

<400>  11

Met Thr Ile Glu Glu Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg 
1               5                   10                  15      


Asp Ile Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp 
            20                  25                  30          


Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val Lys 
        35                  40                  45              


Asp Phe Tyr Leu Met Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala 
    50                  55                  60                  


Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu 
65                  70                  75                  80  


Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala His 
                85                  90                  95      


Ile Val Met Val Asp Ala 
            100         


<210>  12
<211>  309
<212>  DNA
<213>  Streptococcus pyogenes

<400>  12
atgacaattg aagaagatag tgctacccat attaaattct caaaacgtga tattgacggc       60

aaagagttag ctggtgcaac tatggagttg cgtgattcat ctggtaaaac tattagtaca      120

tggatttcag atggacaagt gaaagatttc tacctgatgc caggaaaata tacatttgtc      180

gaaaccgcag caccagacgg ttatgaggta gcaactgcta ttacctttac agttaatgag      240

caaggtcagg ttactgtaaa tggcaaagca actaaaggtg acgctcatat tgtcatggtt      300

gatgcttga                                                              309


<210>  13
<211>  893
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  13

Met Leu Asn Arg Glu Thr His Met Lys Lys Val Arg Lys Ile Phe Gln 
1               5                   10                  15      


Lys Ala Val Ala Gly Leu Cys Cys Ile Ser Gln Leu Thr Ala Phe Ser 
            20                  25                  30          


Ser Ile Val Ala Leu Ala Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly 
        35                  40                  45              


Lys Val Val Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp 
    50                  55                  60                  


Ala Val Phe Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln 
65                  70                  75                  80  


Arg Thr Glu Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro 
                85                  90                  95      


Gly Thr Tyr Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro 
            100                 105                 110         


Ser Thr Lys Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr 
        115                 120                 125             


Val Gln Gly Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln 
    130                 135                 140                 


Tyr Pro Gln Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile 
145                 150                 155                 160 


Ile Lys Val Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn 
                165                 170                 175     


Pro Asn Pro Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg 
            180                 185                 190         


Ile Tyr Gln Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu 
        195                 200                 205             


Thr Val Ser Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro 
    210                 215                 220                 


Leu Asp Val Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile 
225                 230                 235                 240 


Arg Asn Lys Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg 
                245                 250                 255     


Ser Leu Ile Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu 
            260                 265                 270         


Val Thr Tyr Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu 
        275                 280                 285             


Lys Gly Val Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe 
    290                 295                 300                 


Trp Asn Tyr Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser 
305                 310                 315                 320 


Tyr Leu Lys Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn 
                325                 330                 335     


Lys Val Pro Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr 
            340                 345                 350         


Gln Phe Gly Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu 
        355                 360                 365             


Ile Leu Thr Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His 
    370                 375                 380                 


Ile Thr Asp Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His 
385                 390                 395                 400 


Ala Thr Phe Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser 
                405                 410                 415     


Lys Ser Pro Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln 
            420                 425                 430         


Ala Thr Ser Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr 
        435                 440                 445             


Gln Met Phe Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala 
    450                 455                 460                 


Phe Pro Val Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr 
465                 470                 475                 480 


Ala Val Ile Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp 
                485                 490                 495     


Arg Glu Ser Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile 
            500                 505                 510         


Thr Asn His Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala 
        515                 520                 525             


Pro Asp Gly Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp 
    530                 535                 540                 


Pro Gly Thr Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser 
545                 550                 555                 560 


Ser Lys Pro Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu 
                565                 570                 575     


Glu Gln Leu Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser 
            580                 585                 590         


Ile Glu Asn Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu 
        595                 600                 605             


Gln Leu Gly Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr 
    610                 615                 620                 


Ala Asn Asp Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro 
625                 630                 635                 640 


Gln Asn Asp Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr 
                645                 650                 655     


Thr Glu Lys Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu 
            660                 665                 670         


Lys Val Thr Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser 
        675                 680                 685             


Asn Lys Phe Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu 
    690                 695                 700                 


Val Glu Gln Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp 
705                 710                 715                 720 


Val Arg Lys Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly 
                725                 730                 735     


Asp Ile Glu Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg 
            740                 745                 750         


Gly Ala Val Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile 
        755                 760                 765             


Tyr Gly Ala Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly 
    770                 775                 780                 


Glu Asp Gly Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg 
785                 790                 795                 800 


Leu Phe Glu Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys 
                805                 810                 815     


Pro Ile Val Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr 
            820                 825                 830         


Ser Ile Val Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp 
        835                 840                 845             


Lys His Tyr Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Tyr Pro 
    850                 855                 860                 


Arg Thr Gly Gly Ile Gly Met Leu Pro Phe Tyr Leu Ile Gly Cys Met 
865                 870                 875                 880 


Met Met Gly Gly Val Leu Leu Tyr Thr Arg Lys His Pro 
                885                 890             


<210>  14
<211>  2682
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  14
atgctgaacc gcgaaaccca tatgaaaaaa gtaagaaaga tatttcagaa ggcagttgca       60

ggactgtgct gtatatctca gttgacagct ttttcttcga tagttgcttt agcagaaacg      120

cctgaaacca gtccagcgat aggaaaagta gtgattaagg agacaggcga aggaggagcg      180

cttctaggag atgccgtctt tgagttgaaa aacaatacgg atggcacaac tgtttcgcaa      240

aggacagagg cgcaaacagg agaagcgata ttttcaaaca taaaacctgg gacatacacc      300

ttgacagaag cccaacctcc agttggttat aaaccctcta ctaaacaatg gactgttgaa      360

gttgagaaga atggtcggac gactgtccaa ggtgaacagg tagaaaatcg agaagaggct      420

ctatctgacc agtatccaca aacagggact tatccagatg ttcaaacacc ttatcagatt      480

attaaggtag atggttcgga aaaaaacgga cagcacaagg cgttgaatcc gaatccatat      540

gaacgtgtga ttccagaagg tacactttca aagagaattt atcaagtgaa taatttggat      600

gataaccaat atggaatcga attgacggtt agtgggaaaa cagtgtatga acaaaaagat      660

aagtctgtgc cgctggatgt cgttatcttg ctcgataact caaatagtat gagtaacatt      720

cgaaacaaga atgctcgacg tgcggaaaga gctggtgagg cgacacgttc tcttattgat      780

aaaattacat ctgattcaga aaatagggta gcgcttgtga cttatgcttc cactatcttt      840

gatgggaccg agtttacagt agaaaaaggg gtagcagata aaaacggaaa gcgattgaat      900

gattctcttt tttggaatta tgatcagacg agttttacaa ccaataccaa agattatagt      960

tatttaaagc tgactaatga taagaatgac attgtagaat taaaaaataa ggtacctacc     1020

gaggcagaag accatgatgg aaatagattg atgtaccaat tcggtgccac ttttactcag     1080

aaagctttga tgaaggcaga tgagattttg acacaacaag cgagacaaaa tagtcaaaaa     1140

gtcattttcc atattacgga tggtgtccca actatgtcgt atccgattaa ttttaatcat     1200

gctacgtttg ctccatcata tcaaaatcaa ctaaatgcat tttttagtaa atctcctaat     1260

aaagatggaa tactattaag tgattttatt acgcaagcaa ctagtggaga acatacaatt     1320

gtacgcggag atgggcaaag ttaccagatg tttacagata agacagttta tgaaaaaggt     1380

gctcctgcag ctttcccagt taaacctgaa aaatattctg aaatgaaggc ggctggttat     1440

gcagttatag gcgatccaat taatggtgga tatatttggc ttaattggag agagagtatt     1500

ctggcttatc cgtttaattc taatactgct aaaattacca atcatggtga ccctacaaga     1560

tggtactata acgggaatat tgctcctgat gggtatgatg tctttacggt aggtattggt     1620

attaacggag atcctggtac ggatgaagca acggctacta gttttatgca aagtatttct     1680

agtaaacctg aaaactatac caatgttact gacacgacaa aaatattgga acagttgaat     1740

cgttatttcc acaccatcgt aactgaaaag aaatcaattg agaatggtac gattacagat     1800

ccgatgggtg agttaattga tttgcaattg ggcacagatg gaagatttga tccagcagat     1860

tacactttaa ctgcaaacga tggtagtcgc ttggagaatg gacaagctgt aggtggtcca     1920

caaaatgatg gtggtttgtt aaaaaatgca aaagtgctct atgatacgac tgagaaaagg     1980

attcgtgtaa caggtctgta ccttggaacg gatgaaaaag ttacgttgac ctacaatgtt     2040

cgtttgaatg atgagtttgt aagcaataaa ttttatgata ccaatggtcg aacaacctta     2100

catcctaagg aagtagaaca gaacacagtg cgcgacttcc cgattcctaa gattcgtgat     2160

gtgcggaagt atccagaaat cacaatttca aaagagaaaa aacttggtga cattgagttt     2220

attaaggtca ataaaaatga taaaaaacca ctgagaggtg cggtctttag tcttcaaaaa     2280

caacatccgg attatccaga tatttatgga gctattgatc aaaatggcac ttatcaaaat     2340

gtgagaacag gtgaagatgg taagttgacc tttaaaaatc tgtcagatgg gaaatatcga     2400

ttatttgaaa attctgaacc agctggttat aaacccgttc aaaataagcc tatcgttgcc     2460

ttccaaatag taaatggaga agtcagagat gtgacttcaa tcgttccaca agatatacca     2520

gcgggttacg agtttacgaa tgataagcac tatattacca atgaacctat tcctccaaag     2580

agagaatatc ctcgaactgg tggtatcgga atgttgccat tctatctgat aggttgcatg     2640

atgatgggag gagttctatt atacacacgg aaacatccgt aa                        2682


<210>  15
<211>  738
<212>  PRT
<213>  Streptococcus intermedius

<400>  15

Met Lys Lys Arg Arg Gly Gln Phe Phe Lys Ser Ala Ile Ser Phe Leu 
1               5                   10                  15      


Val Val Phe Leu Met Val Met Val Ser Ile Ile Tyr Pro Ser Ser Lys 
            20                  25                  30          


Ile Lys Ala Asp Gly Phe Pro Asn Asp Ala Thr Gly Val Ser Pro Asn 
        35                  40                  45              


Gly Lys Tyr Tyr Ser Ala Gly Arg Glu Asn Arg Leu Gly Met Val Thr 
    50                  55                  60                  


Ser Asp Glu Leu His Thr Ala Thr Glu Leu Phe Gly Phe Cys Met Ala 
65                  70                  75                  80  


Asn Ser Lys Lys Tyr Pro Gly Tyr Asp Ser Lys Lys Asp Glu Tyr Phe 
                85                  90                  95      


Gly Val Tyr Glu Gln Ile Leu Asn Leu Asn Lys Glu Ser Phe Asn Lys 
            100                 105                 110         


Leu Val Arg Asp Asn His Thr Tyr Gly Asn Ile Pro Thr Ser Pro Glu 
        115                 120                 125             


Glu Leu Trp Asp Lys Val Ser Lys Leu Ile Tyr Ile Tyr Leu Lys Asp 
    130                 135                 140                 


Pro Thr Asn Val Ile Gly Gln Ala Gly Trp Thr Asn Pro Gln Asp Ala 
145                 150                 155                 160 


Met Tyr Glu Phe Tyr Thr Val Val Gln Gln Glu Ile Trp Arg Tyr Thr 
                165                 170                 175     


Asp Gly Gln Lys Val Asp Lys Asp Thr Asn Ser Tyr Leu Tyr Tyr Lys 
            180                 185                 190         


Tyr Ser Lys Gln Gly Gln Lys Ala Val Tyr Leu Leu Arg Asp Ala Val 
        195                 200                 205             


Asn Ser Ile Ser Ile Pro Ser Asn Phe Glu Leu Arg Gly Tyr Lys Pro 
    210                 215                 220                 


Glu Trp Val Gln Gly Gln Lys Gly Tyr Gln Ala Ile Val Thr Gly Arg 
225                 230                 235                 240 


Leu Lys Val Asp Gln Pro Val Gly Glu Ile Lys Thr Thr Val Thr Ala 
                245                 250                 255     


Gly Gly Lys Thr Ser Ser Glu Asn Asp Ile Ala Thr Leu Lys Ala Gln 
            260                 265                 270         


Asp Val Ile Gly Gly Val Glu Val Ser Asp Lys Ile Thr Tyr Ser Gly 
        275                 280                 285             


Leu Tyr Pro Asn Thr Glu Tyr Asp Val Ile Gly Glu Ile Tyr Glu Val 
    290                 295                 300                 


Lys Asp Gly Glu Leu Val Asn Pro Gly Arg Pro Val Ser Val Val Asn 
305                 310                 315                 320 


Ser Gly Asp Asp Leu Lys Thr Asp Ala Thr Gly Lys Gly Lys Trp Thr 
                325                 330                 335     


Leu Asn Phe Gly Lys Leu Asp Leu Glu Ala Gly Lys Ser Tyr Val Val 
            340                 345                 350         


Phe Glu Lys Val Val Ser Leu Lys Asn Val Ile Asp Thr Asp Gly Asp 
        355                 360                 365             


Gly Lys Pro Asp Lys Lys Gln Glu Leu Ser His Asn Asp Pro Lys Asp 
    370                 375                 380                 


Lys Ser Gln Thr Phe Thr Ile Leu Pro Lys Glu Ile Val Glu Gln Asp 
385                 390                 395                 400 


Val Val Phe Ser Lys Val Asn Val Ala Gly Glu Glu Ile Ala Gly Ala 
                405                 410                 415     


Lys Ile Gln Leu Lys Asp Ala Gln Gly Gln Val Val His Ser Trp Thr 
            420                 425                 430         


Ser Lys Ala Gly Gln Ser Glu Thr Val Lys Leu Lys Ala Gly Thr Tyr 
        435                 440                 445             


Thr Phe His Glu Ala Ser Ala Pro Thr Gly Tyr Leu Ala Val Thr Asp 
    450                 455                 460                 


Ile Thr Phe Glu Val Asp Val Gln Gly Lys Val Thr Val Lys Asp Ala 
465                 470                 475                 480 


Asn Gly Asn Gly Val Lys Ala Asp Gly Asn Lys Leu Thr Val Thr Asp 
                485                 490                 495     


Gln Ala Ala Pro Ser Val Pro Asn Glu Gln Asp Val Val Phe Ser Lys 
            500                 505                 510         


Val Asn Val Ala Gly Glu Glu Ile Ala Gly Ala Lys Ile Gln Leu Lys 
        515                 520                 525             


Asp Ala Gln Gly Gln Val Val His Ser Trp Thr Ser Lys Ala Gly Gln 
    530                 535                 540                 


Ser Glu Thr Val Lys Leu Lys Ala Gly Thr Tyr Thr Phe His Glu Ala 
545                 550                 555                 560 


Ser Ala Pro Thr Gly Tyr Leu Ala Val Thr Asp Ile Thr Phe Glu Val 
                565                 570                 575     


Asp Val Gln Gly Lys Val Thr Val Lys Asp Ala Asn Gly Asn Gly Val 
            580                 585                 590         


Lys Ala Asp Gly Asn Lys Leu Thr Val Thr Asp Gln Ala Ala Pro Ser 
        595                 600                 605             


Val Pro Asn Glu Gln Asp Val Val Phe Ser Lys Val Asn Val Ala Gly 
    610                 615                 620                 


Glu Glu Ile Ala Gly Ala Lys Ile Gln Leu Lys Asp Ala Gln Gly Gln 
625                 630                 635                 640 


Val Val His Ser Trp Thr Ser Lys Ala Gly Gln Ser Glu Thr Val Lys 
                645                 650                 655     


Leu Lys Ala Gly Thr Tyr Thr Phe His Glu Ala Ser Ala Pro Thr Gly 
            660                 665                 670         


Tyr Leu Ala Val Thr Asp Ile Thr Phe Glu Val Asp Val Gln Gly Lys 
        675                 680                 685             


Val Thr Val Lys Asp Ala Asn Gly Asn Gly Val Lys Ala Asp Gly Asn 
    690                 695                 700                 


Lys Leu Thr Val Thr Asp Gln Ala Ala Pro Ser Val Pro Asn Glu Gln 
705                 710                 715                 720 


Asp Val Val Phe Ser Lys Val Asn Val Ala Gly Glu Glu Ile Ala Gly 
                725                 730                 735     


Ala Lys 
        


<210>  16
<211>  2215
<212>  DNA
<213>  Streptococcus intermedius

<400>  16
atgaaaaaga gaagaggaca atttttcaaa agtgcaattt cgtttttggt tgtatttttg       60

atggtaatgg taagtatcat ttacccatct tcaaaaatta aagcagatgg atttcctaat      120

gatgctacgg gagtatcgcc aaatggtaaa tattactcgg cagggagaga aaaccgttta      180

ggaatggtta catcagatga attgcataca gctacagaat tattcggttt ttgtatggca      240

aatagcaaga aatatccagg atatgattca aaaaaggatg agtattttgg ggtgtatgaa      300

caaatcttaa accttaataa agaaagcttt aataagcttg ttagagataa tcatacgtat      360

ggtaacattc ctacaagtcc agaggaactt tgggataaag tatctaaact gatttatatt      420

tatttgaaag accctacaaa tgttattgga caagctgggt ggacgaatcc acaggatgca      480

atgtatgaat tttatactgt tgtacaacag gaaatatggc gttatacaga tggacaaaag      540

gtggataaag acaccaattc atatttgtat tataaatatt caaaacaagg tcaaaaagca      600

gtgtacttac tgcgtgacgc tgtgaatagc atcagtatac ctagtaattt tgaacttcgt      660

ggctataaac ctgaatgggt tcaaggtcaa aaaggatacc aagctattgt aactggtaga      720

ttgaaagtag atcaacctgt cggggaaata aagactacag taacagcagg tggaaaaacc      780

tcaagtgaaa acgacattgc tacattgaag gcgcaagacg ttataggtgg ggttgaagtc      840

tctgataaga taacatatag tggtctttat ccaaatacag aatatgatgt tataggtgaa      900

atttacgaag taaaagatgg agaacttgtt aatccaggac gaccggtttc tgtagtcaat      960

agtggtgacg atttaaaaac agatgcaaca ggaaaaggga aatggacatt aaactttgga     1020

aagcttgatt tagaagcagg aaaatcctat gtggtctttg aaaaagttgt ttcattaaaa     1080

aacgtgatag atacagatgg agatggaaaa ccggataaaa aacaagaact atcgcataat     1140

gatccaaaag ataaatcgca aacatttaca attttaccta aggaaatagt tgaacaagac     1200

gttgtcttca gtaaggtgaa tgtggctggt gaagaaatcg ctggtgcgaa gatccaactg     1260

aaggatgcgc aaggtcaagt tgttcattcc tggacttcta aagcgggtca aagtgaaacg     1320

gtcaaattga aagctggcac ctatactttc catgaagcat ccgctccgac tggttacttg     1380

gccgtaacgg atatcacatt cgaagtagat gttcaaggaa aagtgacggt taaggatgcc     1440

aacggcaatg gtgttaaggc ggatggtaat aagttaacgg tgaccgatca agctgctcct     1500

agcgtaccga atgaacaaga cgttgtcttc agtaaggtga atgtggctgg tgaagaaatc     1560

gctggtgcga agatccaact gaaggatgcg caaggtcaag ttgttcattc ctggacttct     1620

aaagcgggtc aaagtgaaac ggtcaaattg aaagctggca cctatacttt ccatgaagca     1680

tccgctccga ctggttactt ggccgtaacg gatatcacat tcgaagtaga tgttcaagga     1740

aaagtgacgg ttaaggatgc caacggcaat ggtgttaagg cggatggtaa taagttaacg     1800

gtgaccgatc aagctgctcc tagcgtaccg aatgaacaag acgttgtctt cagtaaggtg     1860

aatgtggctg gtgaagaaat cgctggtgcg aagatccaac tgaaggatgc gcaaggtcaa     1920

gttgttcatt cctggacttc taaagcgggt caaagtgaaa cggtcaaatt gaaagctggc     1980

acctatactt tccatgaagc atccgctccg actggttact tggccgtaac ggatatcaca     2040

ttcgaagtag atgttcaagg aaaagtgacg gttaaggatg ccaacggcaa tggtgttaag     2100

gcggatggta ataagttaac ggtgaccgat caagctgctc ctagcgtacc gaatgaacaa     2160

gacgttgtct tcagtaaggt gaatgtggct ggtgaagaaa tcgctggtgc gaaga          2215


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any amino acid

<400>  17

Leu Pro Xaa Thr Gly 
1               5   


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Leu Pro Thr Gly Ala Ala 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Leu Pro Thr Gly Gly Gly 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Leu Pro Lys Thr Gly Gly 
1               5       


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21

Leu Pro Glu Thr Gly 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any amino acid

<400>  22

Leu Pro Xaa Thr Gly 
1               5   


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is any amino acid

<400>  23

Leu Pro Xaa Thr Gly Xaa 
1               5       


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is glutamine or lysine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is asparagine or glycine

<400>  24

Asn Pro Xaa Thr Xaa 
1               5   


<210>  25
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Val Pro Thr Ile Val Met Val Asp Ala Tyr Lys Arg Tyr 
            20                  25                  30          


Lys Gly Ser Gly Glu Ser Gly Lys 
        35                  40  


<210>  26
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Val Thr Thr Leu Ser Gly 
            20                  25                  30          


Leu Ser Gly Glu Gln Gly Pro Ser Gly Asp Met Thr Thr Glu Glu Asp 
        35                  40                  45              


Ser Ala Thr His Ile Lys Phe Ser Lys Arg Asp Glu Asp Gly Arg Glu 
    50                  55                  60                  


Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser Ser Gly Lys Thr Ile 
65                  70                  75                  80  


Ser Thr Trp Ile Ser Asp Gly His Val Lys Asp Phe Tyr Leu Tyr Pro 
                85                  90                  95      


Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala Pro Asp Gly Tyr Glu Val 
            100                 105                 110         


Ala Thr Ala Ile Thr Phe Thr Val Asn Glu Gln Gly Gln Val Thr Val 
        115                 120                 125             


Asn Gly Glu Ala Thr Lys Gly Asp Ala His Thr 
    130                 135                 


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27

Val Pro Thr Ile Val Met Val Asp Ala Tyr Lys Arg Tyr Lys Ser 
1               5                   10                  15  


<210>  28
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpyCatcher002

<400>  28

Ala Met Val Thr Thr Leu Ser Gly Leu Ser Gly Glu Gln Gly Pro Ser 
1               5                   10                  15      


Gly Asp Met Thr Thr Glu Glu Asp Ser Ala Thr His Ile Lys Phe Ser 
            20                  25                  30          


Lys Arg Asp Glu Asp Gly Arg Glu Leu Ala Gly Ala Thr Met Glu Leu 
        35                  40                  45              


Arg Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly His 
    50                  55                  60                  


Val Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr 
65                  70                  75                  80  


Ala Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val 
                85                  90                  95      


Asn Glu Gln Gly Gln Val Thr Val Asn Gly Glu Ala Thr Lys Gly Asp 
            100                 105                 110         


Ala His Thr Gly Ser Ser Gly Ser 
        115                 120 


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29

Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
1               5                   10              


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30

Ala His Ile Val Met Val Asp Ala Tyr Lys 
1               5                   10  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Gly Gly Gly Gly Ser 
1               5   


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33

Ala Thr His Ile Lys Phe Ser Lys Arg Asp 
1               5                   10  


<210>  34
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpyTag002

<400>  34

Val Pro Thr Ile Val Met Val Asp Ala Tyr Lys Arg Tyr Lys 
1               5                   10                  


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SnoopTag

<400>  35

Lys Leu Gly Asp Ile Glu Phe Ile Lys Val Asn Lys 
1               5                   10          


<210>  36
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SnoopCatcher

<400>  36

Lys Pro Leu Arg Gly Ala Val Phe Ser Leu Gln Lys Gln His Pro Asp 
1               5                   10                  15      


Tyr Pro Asp Ile Tyr Gly Ala Ile Asp Gln Asn Gly Thr Tyr Gln Asn 
            20                  25                  30          


Val Arg Thr Gly Glu Asp Gly Lys Leu Thr Phe Lys Asn Leu Ser Asp 
        35                  40                  45              


Gly Lys Tyr Arg Leu Phe Glu Asn Ser Glu Pro Ala Gly Tyr Lys Pro 
    50                  55                  60                  


Val Gln Asn Lys Pro Ile Val Ala Phe Gln Ile Val Asn Gly Glu Val 
65                  70                  75                  80  


Arg Asp Val Thr Ser Ile Val Pro Gln Asp Ile Pro Ala Thr Tyr Glu 
                85                  90                  95      


Phe Thr Asn Gly Lys His Tyr Ile Thr Asn Glu Pro Ile Pro Pro Lys 
            100                 105                 110         


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SnoopTagJr

<400>  37

Lys Leu Gly Ser Ile Glu Phe Ile Lys Val Asn Lys 
1               5                   10          


<210>  38
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DogTag

<400>  38

Asp Ile Pro Ala Thr Tyr Glu Phe Thr Asn Gly Lys His Tyr Ile Thr 
1               5                   10                  15      


Asn Glu Pro Ile Pro Pro Lys 
            20              


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Isopeptag

<400>  39

Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Ala Glu 
1               5                   10                  15      


<210>  40
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Split Spy0128

<400>  40

Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu Thr 
1               5                   10                  15      


Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro Asn 
            20                  25                  30          


Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu Asp 
        35                  40                  45              


Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys Val 
    50                  55                  60                  


Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala Glu 
65                  70                  75                  80  


Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr Tyr 
                85                  90                  95      


Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr Asp 
            100                 105                 110         


Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu Gln 
        115                 120                 125             


Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser Lys 
    130                 135                 140                 


Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr Val 
145                 150                 155                 160 


Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe Asn 
                165                 170                 175     


Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu Lys 
            180                 185                 190         


Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln Thr 
        195                 200                 205             


Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly Glu 
    210                 215                 220                 


Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val Thr 
225                 230                 235                 240 


Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val Ser 
                245                 250                 255     


Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu Gln 
            260                 265                 270         


Glu Thr Ser Thr Asp Lys Asp Met Thr Ile 
        275                 280         


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SdyTag

<400>  41

Asp Pro Ile Val Met Ile Asp Asn Asp Lys Pro Ile Thr 
1               5                   10              


<210>  42
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SdyCatcherDANG short

<400>  42

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg 
            20                  25                  30          


Gly Ser Ser Gly Leu Ser Gly Glu Thr Gly Gln Ser Gly Asn Thr Thr 
        35                  40                  45              


Ile Glu Glu Asp Ser Thr Thr His Val Lys Phe Ser Lys Arg Asp Ala 
    50                  55                  60                  


Asn Gly Lys Glu Leu Ala Gly Ala Met Ile Glu Leu Arg Asn Leu Ser 
65                  70                  75                  80  


Gly Gln Thr Ile Gln Ser Trp Ile Ser Asp Gly Thr Val Lys Val Phe 
                85                  90                  95      


Tyr Leu Met Pro Gly Thr Tyr Gln Phe Val Glu Thr Ala Ala Pro Glu 
            100                 105                 110         


Gly Tyr Glu Leu Ala Ala Pro Ile Thr Phe Thr Ile Asp Glu Lys Gly 
        115                 120                 125             


Gln Ile Trp Val Asp Ser 
    130                 


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43

Arg Gly Val Pro His Ile Val Met Val Asp Ala Tyr Lys Arg Tyr Lys 
1               5                   10                  15      


<210>  44
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Val Thr Thr Leu Ser Gly Leu Ser Gly Glu Gln Gly Pro Ser Gly Asp 
1               5                   10                  15      


Met Thr Thr Glu Glu Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg 
            20                  25                  30          


Asp Glu Asp Gly Arg Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp 
        35                  40                  45              


Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly His Val Lys 
    50                  55                  60                  


Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala 
65                  70                  75                  80  


Pro Asp Gly Tyr Glu Val Ala Thr Pro Ile Glu Phe Thr Val Asn Glu 
                85                  90                  95      


Asp Gly Gln Val Thr Val Asp Gly Glu Ala Thr Glu Gly Asp Ala His 
            100                 105                 110         


Thr 
    


