                               SEQUENCE LISTING

<110> LUDWIG INSTITUTE FOR CANCER RESEARCH LTD
      UNIVERSITY OF LAUSANNE
      CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
      SIB SWISS INSTITUTE OF BIOINFORMATICS
 
<120> A2/NY-ESO-1 SPECIFIC T CELL RECEPTORS AND USES THEREOF

<130> 252457.000009

<140> PCT/IB2020/000140
<141> 2020-03-17

<150> 62/819,988
<151> 2019-03-18

<160> 82    

<170> PatentIn version 3.5

<210> 1
<211> 311
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      BC1 WT beta chain sequence"

<400> 1
Met Ala Pro Arg Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Ala Ala Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210> 2
<211> 311
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Met Ala Pro Arg Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Glu Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Ala Ala Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210> 3
<211> 311
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Met Ala Pro Arg Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Phe Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Ala Ala Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210> 4
<211> 311
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Met Ala Pro Arg Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Trp Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Ala Ala Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210> 5
<211> 311
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met Ala Pro Arg Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Glu Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Ala Ala Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210> 6
<211> 311
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Met Ala Pro Arg Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Leu Ala Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210> 7
<211> 274
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      BC1 WT alpha chain sequence"

<400> 7
Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Gln Thr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210> 8
<211> 9
<212> PRT
<213> Homo sapiens

<400> 8
Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210> 9
<211> 822
<212> DNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      BC1 WT alpha chain sequence"

<400> 9
atggaaaccc tgctgggcct gctgatcctg tggctgcagc tgcagtgggt gtccagcaag       60

caggaagtga cccagatccc tgccgccctg agcgtgcccg agggcgagaa cctggtgctg      120

aactgcagct tcaccgacag cgccatctac aacctgcagt ggttccggca ggaccccggc      180

aagggcctga ccagcctgct gctgatccag agcagccagc gggagcagac cagcggcagg      240

ctgaacgcca gcctggacaa gagcagcggc agaagcaccc tgtacatcgc cgccagccag      300

cccggcgact ccgccaccta cctgtgcgcc gtgcggcctc agaccggcgg cagctacatc      360

cccaccttcg gcaggggcac cagcctgatc gtgcacccct acatccagaa ccccgacccc      420

gccgtgtacc agctgcggga cagcaagtcc agcgacaaga gcgtgtgcct gttcaccgac      480

ttcgacagcc agaccaacgt gagccagagc aaggacagcg acgtgtacat caccgacaag      540

accgtgctgg acatgcggag catggacttc aagagcaaca gcgccgtggc ctggtccaac      600

aagagcgact tcgcctgcgc caacgccttc aacaacagca tcatccccga ggacaccttt      660

ttccccagcc ccgagagcag ctgcgacgtg aaactggtgg agaagagctt cgagaccgac      720

accaacctga acttccagaa cctgagcgtg atcggcttca gaattctgct gctgaaggtg      780

gccggcttca acctgctgat gaccctgcgg ctgtggagca gt                         822


<210> 10
<211> 936
<212> DNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      BC1 WT beta chain sequence"

<400> 10
atggccccgc ggctgctgtg ttgtgccgcc ctgagcctgc tgtgggccgg acctgtgaac       60

gccggcgtga cccagacccc caagttccag gtgctgaaaa ccggccagag catgaccctg      120

cagtgcgccc aggacatgaa ccacgagtac atgagctggt acaggcagga ccccggcatg      180

ggcctgcggc tgatccacta cagcgtggga gccggcatca ccgaccaggg cgaggtgccc      240

aacggctaca acgtgagcag aagcaccacc gaggacttcc ccctgaggct gctgtctgcc      300

gcccctagcc agaccagcgt gtacttctgc gccagcagct atgtgggagc cgccggagag      360

ctgttcttcg gcgagggcag ccggctgacc gtgctggaag atctgaacaa agtgttcccc      420

cccgaagtgg ccgtgttcga gcccagcgag gccgagatca gccacaccca gaaggccacc      480

ctggtgtgtc tggccaccgg cttcttcccc gaccacgtgg agctgtcctg gtgggtgaac      540

ggcaaggaag tgcacagcgg cgtgtccacc gacccccagc ccctgaagga gcagcccgcc      600

ctgaacgata gcagatactg cctgagcagc cggctgagag tgagcgccac cttctggcag      660

aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag      720

tggacccagg atagagccaa gcccgtgacc cagatcgtgt ccgccgaggc ctggggcaga      780

gccgactgcg gcttcaccag cgtgtcctac cagcagggcg tgctgagcgc cacaatcctg      840

tacgagatcc tgctgggcaa ggccacactg tacgccgtgc tggtgtccgc cctggtgctg      900

atggctatgg tgaagcggaa ggacagcagg ggctga                                936


<210> 11
<211> 936
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
atggccccgc ggctgctgtg ttgtgccgcc ctgagcctgc tgtgggccgg acctgtgaac       60

gccggcgtga cccagacccc caagttccag gtgctgaaaa ccggccagag catgaccctg      120

cagtgcgccc aggacatgaa ccacgagtac atgagctggt acaggcagga ccccggcatg      180

ggcctgcggc tgatccacta cagcgtggga gccggcgaga ccgaccaggg cgaggtgccc      240

aacggctaca acgtgagcag aagcaccacc gaggacttcc ccctgaggct gctgtctgcc      300

gcccctagcc agaccagcgt gtacttctgc gccagcagct atgtgggagc cgccggagag      360

ctgttcttcg gcgagggcag ccggctgacc gtgctggaag atctgaacaa agtgttcccc      420

cccgaagtgg ccgtgttcga gcccagcgag gccgagatca gccacaccca gaaggccacc      480

ctggtgtgtc tggccaccgg cttcttcccc gaccacgtgg agctgtcctg gtgggtgaac      540

ggcaaggaag tgcacagcgg cgtgtccacc gacccccagc ccctgaagga gcagcccgcc      600

ctgaacgata gcagatactg cctgagcagc cggctgagag tgagcgccac cttctggcag      660

aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag      720

tggacccagg atagagccaa gcccgtgacc cagatcgtgt ccgccgaggc ctggggcaga      780

gccgactgcg gcttcaccag cgtgtcctac cagcagggcg tgctgagcgc cacaatcctg      840

tacgagatcc tgctgggcaa ggccacactg tacgccgtgc tggtgtccgc cctggtgctg      900

atggctatgg tgaagcggaa ggacagcagg ggctga                                936


<210> 12
<211> 936
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 12
atggccccgc ggctgctgtg ttgtgccgcc ctgagcctgc tgtgggccgg acctgtgaac       60

gccggcgtga cccagacccc caagttccag gtgctgaaaa ccggccagag catgaccctg      120

cagtgcgccc aggacatgaa ccacgagtac atgagctggt acaggcagga ccccggcatg      180

ggcctgcggc tgatccacta cagcgtggga gccggcttca ccgaccaggg cgaggtgccc      240

aacggctaca acgtgagcag aagcaccacc gaggacttcc ccctgaggct gctgtctgcc      300

gcccctagcc agaccagcgt gtacttctgc gccagcagct atgtgggagc cgccggagag      360

ctgttcttcg gcgagggcag ccggctgacc gtgctggaag atctgaacaa agtgttcccc      420

cccgaagtgg ccgtgttcga gcccagcgag gccgagatca gccacaccca gaaggccacc      480

ctggtgtgtc tggccaccgg cttcttcccc gaccacgtgg agctgtcctg gtgggtgaac      540

ggcaaggaag tgcacagcgg cgtgtccacc gacccccagc ccctgaagga gcagcccgcc      600

ctgaacgata gcagatactg cctgagcagc cggctgagag tgagcgccac cttctggcag      660

aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag      720

tggacccagg atagagccaa gcccgtgacc cagatcgtgt ccgccgaggc ctggggcaga      780

gccgactgcg gcttcaccag cgtgtcctac cagcagggcg tgctgagcgc cacaatcctg      840

tacgagatcc tgctgggcaa ggccacactg tacgccgtgc tggtgtccgc cctggtgctg      900

atggctatgg tgaagcggaa ggacagcagg ggctga                                936


<210> 13
<211> 936
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 13
atggccccgc ggctgctgtg ttgtgccgcc ctgagcctgc tgtgggccgg acctgtgaac       60

gccggcgtga cccagacccc caagttccag gtgctgaaaa ccggccagag catgaccctg      120

cagtgcgccc aggacatgaa ccacgagtac atgagctggt acaggcagga ccccggcatg      180

ggcctgcggc tgatccacta cagcgtggga gccggctgga ccgaccaggg cgaggtgccc      240

aacggctaca acgtgagcag aagcaccacc gaggacttcc ccctgaggct gctgtctgcc      300

gcccctagcc agaccagcgt gtacttctgc gccagcagct atgtgggagc cgccggagag      360

ctgttcttcg gcgagggcag ccggctgacc gtgctggaag atctgaacaa agtgttcccc      420

cccgaagtgg ccgtgttcga gcccagcgag gccgagatca gccacaccca gaaggccacc      480

ctggtgtgtc tggccaccgg cttcttcccc gaccacgtgg agctgtcctg gtgggtgaac      540

ggcaaggaag tgcacagcgg cgtgtccacc gacccccagc ccctgaagga gcagcccgcc      600

ctgaacgata gcagatactg cctgagcagc cggctgagag tgagcgccac cttctggcag      660

aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag      720

tggacccagg atagagccaa gcccgtgacc cagatcgtgt ccgccgaggc ctggggcaga      780

gccgactgcg gcttcaccag cgtgtcctac cagcagggcg tgctgagcgc cacaatcctg      840

tacgagatcc tgctgggcaa ggccacactg tacgccgtgc tggtgtccgc cctggtgctg      900

atggctatgg tgaagcggaa ggacagcagg ggctga                                936


<210> 14
<211> 936
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 14
atggccccgc ggctgctgtg ttgtgccgcc ctgagcctgc tgtgggccgg acctgtgaac       60

gccggcgtga cccagacccc caagttccag gtgctgaaaa ccggccagag catgaccctg      120

cagtgcgccc aggacatgaa ccacgagtac atgagctggt acaggcagga ccccggcatg      180

ggcctgcggc tgatccacta cagcgtggga gccggcatca ccgagcaggg cgaggtgccc      240

aacggctaca acgtgagcag aagcaccacc gaggacttcc ccctgaggct gctgtctgcc      300

gcccctagcc agaccagcgt gtacttctgc gccagcagct atgtgggagc cgccggagag      360

ctgttcttcg gcgagggcag ccggctgacc gtgctggaag atctgaacaa agtgttcccc      420

cccgaagtgg ccgtgttcga gcccagcgag gccgagatca gccacaccca gaaggccacc      480

ctggtgtgtc tggccaccgg cttcttcccc gaccacgtgg agctgtcctg gtgggtgaac      540

ggcaaggaag tgcacagcgg cgtgtccacc gacccccagc ccctgaagga gcagcccgcc      600

ctgaacgata gcagatactg cctgagcagc cggctgagag tgagcgccac cttctggcag      660

aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag      720

tggacccagg atagagccaa gcccgtgacc cagatcgtgt ccgccgaggc ctggggcaga      780

gccgactgcg gcttcaccag cgtgtcctac cagcagggcg tgctgagcgc cacaatcctg      840

tacgagatcc tgctgggcaa ggccacactg tacgccgtgc tggtgtccgc cctggtgctg      900

atggctatgg tgaagcggaa ggacagcagg ggctga                                936


<210> 15
<211> 141
<212> PRT
<213> Mus musculus

<400> 15
Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
    50                  55                  60                  


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
65                  70                  75                  80  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
                85                  90                  95      


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
            100                 105                 110         


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
        115                 120                 125             


Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
    130                 135                 140     


<210> 16
<211> 423
<212> DNA
<213> Mus musculus

<400> 16
atgtggctgc agaatttact tttcctgggc attgtggtct acagcctctc agcacccacc       60

cgctcaccca tcactgtcac ccggccttgg aagcatgtag aggccatcaa agaagccctg      120

aacctcctgg atgacatgcc tgtcacattg aatgaagagg tagaagtcgt ctctaacgag      180

ttctccttca agaagctaac atgtgtgcag acccgcctga agatattcga gcagggtcta      240

cggggcaatt tcaccaaact caagggcgcc ttgaacatga cagccagcta ctaccagaca      300

tactgccccc caactccgga aacggactgt gaaacacaag ttaccaccta tgcggatttc      360

atagacagcc ttaaaacctt tctgactgat atcccctttg aatgcaaaaa accaggccaa      420

aaa                                                                    423


<210> 17
<211> 17
<212> PRT
<213> Mus musculus

<400> 17
Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser 
    


<210> 18
<211> 51
<212> DNA
<213> Mus musculus

<400> 18
atgtggctgc agaatttact tttcctgggc attgtggtct acagcctctc a                51


<210> 19
<211> 124
<212> PRT
<213> Mus musculus

<400> 19
Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val 
1               5                   10                  15      


Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr 
            20                  25                  30          


Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys 
        35                  40                  45              


Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg 
    50                  55                  60                  


Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr 
65                  70                  75                  80  


Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln 
                85                  90                  95      


Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr 
            100                 105                 110         


Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
        115                 120                 


<210> 20
<211> 372
<212> DNA
<213> Mus musculus

<400> 20
gcacccaccc gctcacccat cactgtcacc cggccttgga agcatgtaga ggccatcaaa       60

gaagccctga acctcctgga tgacatgcct gtcacattga atgaagaggt agaagtcgtc      120

tctaacgagt tctccttcaa gaagctaaca tgtgtgcaga cccgcctgaa gatattcgag      180

cagggtctac ggggcaattt caccaaactc aagggcgcct tgaacatgac agccagctac      240

taccagacat actgcccccc aactccggaa acggactgtg aaacacaagt taccacctat      300

gcggatttca tagacagcct taaaaccttt ctgactgata tcccctttga atgcaaaaaa      360

ccaggccaaa aa                                                          372


<210> 21
<211> 144
<212> PRT
<213> Homo sapiens

<400> 21
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Thr Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 22
<211> 432
<212> DNA
<213> Homo sapiens

<400> 22
atgtggctgc aatctctgct gctgctgggc acagtggcct gttctattag cgcccctgcc       60

agatctccat ctcctagcac acagccttgg gagcacgtga acgccatcca agaagccaga      120

cggctgctga acctgagcag agatacagcc gccgagatga acgagacagt ggaagtgatc      180

agcgagatgt tcgacctgca agagcctacc tgcctgcaga ccagactgga actgtacaag      240

cagggcctga gaggcagcct gaccaagctg aaaggccctc tgacaatgat ggccagccac      300

tacaagcagc actgccctcc aacacctgag acaagctgtg ccacacagac catcaccttc      360

gagagcttca aagagaacct gaaggacttc ctgctggtca tccccttcga ctgctgggag      420

cccgtgcaag aa                                                          432


<210> 23
<211> 17
<212> PRT
<213> Homo sapiens

<400> 23
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser 
    


<210> 24
<211> 51
<212> DNA
<213> Homo sapiens

<400> 24
atgtggctgc aatctctgct gctgctgggc acagtggcct gttctattag c                51


<210> 25
<211> 127
<212> PRT
<213> Homo sapiens

<400> 25
Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Thr Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210> 26
<211> 381
<212> DNA
<213> Homo sapiens

<400> 26
gcccctgcca gatctccatc tcctagcaca cagccttggg agcacgtgaa cgccatccaa       60

gaagccagac ggctgctgaa cctgagcaga gatacagccg ccgagatgaa cgagacagtg      120

gaagtgatca gcgagatgtt cgacctgcaa gagcctacct gcctgcagac cagactggaa      180

ctgtacaagc agggcctgag aggcagcctg accaagctga aaggccctct gacaatgatg      240

gccagccact acaagcagca ctgccctcca acacctgaga caagctgtgc cacacagacc      300

atcaccttcg agagcttcaa agagaacctg aaggacttcc tgctggtcat ccccttcgac      360

tgctgggagc ccgtgcaaga a                                                381


<210> 27
<211> 564
<212> PRT
<213> Homo sapiens

<400> 27
Met Lys Glu His Gly Gly Thr Phe Ser Ser Thr Gly Ile Ser Gly Gly 
1               5                   10                  15      


Ser Gly Asp Ser Ala Met Asp Ser Leu Gln Pro Leu Gln Pro Asn Tyr 
            20                  25                  30          


Met Pro Val Cys Leu Phe Ala Glu Glu Ser Tyr Gln Lys Leu Ala Met 
        35                  40                  45              


Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Ile 
    50                  55                  60                  


Gln Thr Tyr Arg Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg 
65                  70                  75                  80  


Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly 
                85                  90                  95      


Asn Gln Val Ser Glu Tyr Ile Ser Asn Thr Phe Leu Asp Lys Gln Asn 
            100                 105                 110         


Asp Val Glu Ile Pro Ser Pro Thr Gln Lys Asp Arg Glu Lys Lys Lys 
        115                 120                 125             


Lys Gln Gln Leu Met Thr Gln Ile Ser Gly Val Lys Lys Leu Met His 
    130                 135                 140                 


Ser Ser Ser Leu Asn Asn Thr Ser Ile Ser Arg Phe Gly Val Asn Thr 
145                 150                 155                 160 


Glu Asn Glu Asp His Leu Ala Lys Glu Leu Glu Asp Leu Asn Lys Trp 
                165                 170                 175     


Gly Leu Asn Ile Phe Asn Val Ala Gly Tyr Ser His Asn Arg Pro Leu 
            180                 185                 190         


Thr Cys Ile Met Tyr Ala Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr 
        195                 200                 205             


Phe Arg Ile Ser Ser Asp Thr Phe Ile Thr Tyr Met Met Thr Leu Glu 
    210                 215                 220                 


Asp His Tyr His Ser Asp Val Ala Tyr His Asn Ser Leu His Ala Ala 
225                 230                 235                 240 


Asp Val Ala Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Asp 
                245                 250                 255     


Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ala Ala 
            260                 265                 270         


Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn 
        275                 280                 285             


Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Glu Ser Val Leu Glu 
    290                 295                 300                 


Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu His Cys 
305                 310                 315                 320 


Asp Ile Phe Met Asn Leu Thr Lys Lys Gln Arg Gln Thr Leu Arg Lys 
                325                 330                 335     


Met Val Ile Asp Met Val Leu Ala Thr Asp Met Ser Lys His Met Ser 
            340                 345                 350         


Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser 
        355                 360                 365             


Ser Gly Val Leu Leu Leu Asp Asn Tyr Thr Asp Arg Ile Gln Val Leu 
    370                 375                 380                 


Arg Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Ser Leu 
385                 390                 395                 400 


Glu Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Gln 
                405                 410                 415     


Gln Gly Asp Lys Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys 
            420                 425                 430         


Asp Lys His Thr Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp 
        435                 440                 445             


Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val Gln Pro 
    450                 455                 460                 


Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Asn Trp Tyr 
465                 470                 475                 480 


Gln Ser Met Ile Pro Gln Ser Pro Ser Pro Pro Leu Asp Glu Gln Asn 
                485                 490                 495     


Arg Asp Cys Gln Gly Leu Met Glu Lys Phe Gln Phe Glu Leu Thr Leu 
            500                 505                 510         


Asp Glu Glu Asp Ser Glu Gly Pro Glu Lys Glu Gly Glu Gly His Ser 
        515                 520                 525             


Tyr Phe Ser Ser Thr Lys Thr Leu Cys Val Ile Asp Pro Glu Asn Arg 
    530                 535                 540                 


Asp Ser Leu Gly Glu Thr Asp Ile Asp Ile Ala Thr Glu Asp Lys Ser 
545                 550                 555                 560 


Pro Val Asp Thr 
                


<210> 28
<211> 1692
<212> DNA
<213> Homo sapiens

<400> 28
atgaaggaac acggcggcac ctttagcagc acaggcatct ctggtggcag cggcgatagc       60

gccatggatt ctctgcaacc cctgcagcct aactacatgc ccgtgtgcct gttcgccgag      120

gaaagctacc agaaactggc catggaaacc ctggaagaac tggactggtg cctggaccag      180

ctggaaacca tccagaccta cagatccgtg tccgagatgg ccagcaacaa gttcaagcgg      240

atgctgaaca gagagctgac ccacctgagc gagatgagcc gctctggaaa tcaggtgtcc      300

gagtatatca gcaacacctt cctggacaag cagaacgacg tggaaatccc atctcctaca      360

cagaaggacc gcgagaagaa gaaaaagcag cagctgatga cccagatcag cggcgtgaag      420

aaactgatgc acagcagcag cctgaacaac accagcatca gcagattcgg cgtgaacacc      480

gagaacgagg accacctggc caaagagctg gaagatctga acaaatgggg cctgaacatc      540

ttcaacgtgg ccggctacag ccacaacaga cccctgacct gcattatgta cgccatcttc      600

caagagcggg acctgctgaa aaccttccgg atcagcagcg acaccttcat cacctacatg      660

atgacccttg aggaccacta ccacagcgac gtggcctacc acaatagcct gcatgccgct      720

gatgtggccc agagcacaca cgtgctgctg tctacaccag ctctggatgc cgtgttcacc      780

gacctggaaa ttctggccgc catctttgcc gccgctatcc acgatgttga tcaccccggc      840

gtgtccaacc agttcctgat caataccaac agcgagctgg ccctgatgta caacgacgag      900

agcgtgctgg aaaaccacca tctggccgtg ggcttcaagc tgctgcaaga ggaacactgc      960

gacatcttca tgaacctgac caagaagcag cggcagaccc tgcggaagat ggtcatcgat     1020

atggtgctgg ccaccgacat gagcaagcac atgtctctgc tggccgacct gaaaaccatg     1080

gtcgagacaa agaaagtgac cagcagcggc gttctgctgc tggacaacta caccgacaga     1140

atccaggtgc tgagaaacat ggtgcactgc gccgatctga gcaaccccac caagagcctg     1200

gaactgtaca gacagtggac cgaccggatc atggaagagt tctttcagca aggcgacaaa     1260

gaacgcgagc gcggcatgga aatctcccca atgtgcgata agcacaccgc cagcgtggaa     1320

aagtcccaag tgggctttat cgactacatc gtgcaccctc tgtgggagac atgggccgat     1380

ctggttcagc ctgacgctca ggacatcctg gacacactgg aagataaccg gaactggtat     1440

cagagcatga tccctcagag cccctctcca cctctggatg agcagaacag agattgccag     1500

ggcctgatgg aaaagttcca gttcgagctg acactggacg aagaggactc tgagggcccc     1560

gagaaagaag gcgagggcca cagctacttc agcagcacaa agaccctgtg cgtgatcgac     1620

cccgagaaca gggatagcct gggcgagaca gacatcgaca ttgccaccga ggacaagagc     1680

cccgtggata ca                                                         1692


<210> 29
<211> 564
<212> PRT
<213> Mus musculus

<400> 29
Met Lys Glu Gln Gly Gly Thr Val Ser Gly Ala Ala Ser Ser Arg Gly 
1               5                   10                  15      


Gly Gly Asp Ser Ala Met Ala Ser Leu Gln Pro Leu Gln Pro Asn Tyr 
            20                  25                  30          


Leu Ser Val Cys Leu Phe Pro Glu Glu Ser Tyr Gln Lys Leu Ala Met 
        35                  40                  45              


Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Ile 
    50                  55                  60                  


Gln Thr Tyr Arg Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg 
65                  70                  75                  80  


Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly 
                85                  90                  95      


Asn Gln Val Ser Glu Tyr Ile Ser Asn Thr Phe Leu Asp Lys Gln Asn 
            100                 105                 110         


Asp Val Glu Ile Pro Ser Pro Thr Gln Lys Asp Arg Glu Lys Lys Lys 
        115                 120                 125             


Lys Gln Gln Leu Met Thr Gln Ile Ser Gly Val Lys Lys Leu Met His 
    130                 135                 140                 


Ser Ser Ser Leu Asn Asn Thr Ser Ile Ser Arg Phe Gly Val Asn Thr 
145                 150                 155                 160 


Glu Asn Glu Asp His Leu Ala Lys Glu Leu Glu Asp Leu Asn Lys Trp 
                165                 170                 175     


Gly Leu Asn Ile Phe Asn Val Ala Gly Tyr Ser His Asn Arg Pro Leu 
            180                 185                 190         


Thr Cys Ile Met Tyr Ala Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr 
        195                 200                 205             


Phe Lys Ile Ser Ser Asp Thr Phe Val Thr Tyr Met Met Thr Leu Glu 
    210                 215                 220                 


Asp His Tyr His Ser Asp Val Ala Tyr His Asn Ser Leu His Ala Ala 
225                 230                 235                 240 


Asp Val Ala Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Asp 
                245                 250                 255     


Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ala Ala 
            260                 265                 270         


Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn 
        275                 280                 285             


Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Glu Ser Val Leu Glu 
    290                 295                 300                 


Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu His Cys 
305                 310                 315                 320 


Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Thr Leu Arg Lys 
                325                 330                 335     


Met Val Ile Asp Met Val Leu Ala Thr Asp Met Ser Lys His Met Ser 
            340                 345                 350         


Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser 
        355                 360                 365             


Ser Gly Val Leu Leu Leu Asp Asn Tyr Thr Asp Arg Ile Gln Val Leu 
    370                 375                 380                 


Arg Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Ser Leu 
385                 390                 395                 400 


Glu Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Gln 
                405                 410                 415     


Gln Gly Asp Lys Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys 
            420                 425                 430         


Asp Lys His Thr Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp 
        435                 440                 445             


Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val Gln Pro 
    450                 455                 460                 


Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Asn Trp Tyr 
465                 470                 475                 480 


Gln Ser Met Ile Pro Gln Ser Pro Ser Pro Pro Leu Asp Glu Arg Ser 
                485                 490                 495     


Arg Asp Cys Gln Gly Leu Met Glu Lys Phe Gln Phe Glu Leu Thr Leu 
            500                 505                 510         


Glu Glu Glu Asp Ser Glu Gly Pro Glu Lys Glu Gly Glu Gly His Ser 
        515                 520                 525             


Tyr Phe Ser Ser Thr Lys Thr Leu Cys Val Ile Asp Pro Glu Asn Arg 
    530                 535                 540                 


Asp Ser Leu Glu Glu Thr Asp Ile Asp Ile Ala Thr Glu Asp Lys Ser 
545                 550                 555                 560 


Pro Ile Asp Thr 
                


<210> 30
<211> 1692
<212> DNA
<213> Mus musculus

<400> 30
atgaaggaac agggcggcac cgtgtctggc gccgcttcta gtagaggcgg aggcgatagc       60

gccatggcca gtctgcagcc actgcagccc aactacctga gcgtgtgcct gttccccgag      120

gaaagctacc agaaactggc tatggaaacc ctggaagaac tggactggtg cctggaccag      180

ctggaaacca tccagaccta cagatccgtg tccgagatgg ccagcaacaa gttcaagagg      240

atgctgaaca gagagctgac ccacctgagc gagatgagca gatccggcaa ccaggtgtcc      300

gagtatatca gcaacacctt cctggacaag cagaacgacg tggaaatccc cagccccacc      360

cagaaggacc gcgagaagaa gaaaaagcag cagctgatga cccagatcag cggcgtgaag      420

aaactgatgc acagcagcag cctgaacaac accagcatca gcagattcgg cgtgaacacc      480

gagaacgagg accacctggc caaagagctg gaagatctga acaaatgggg cctgaacatc      540

ttcaacgtgg ccggctacag ccacaacaga cccctgacct gcattatgta cgccatcttc      600

caggaacggg acctgctgaa aaccttcaag atcagcagcg acaccttcgt gacctacatg      660

atgacactgg aagatcacta ccacagcgac gtggcctacc acaactctct gcacgccgcc      720

gatgtggccc agagcactca tgtgctgctg agcacccctg ccctggacgc cgtgttcacc      780

gatctggaaa tcctggccgc tatcttcgcc gctgccatcc acgatgtgga ccaccctggc      840

gtgtccaacc agttcctgat caacacaaac agcgagctgg ccctgatgta caacgacgag      900

agcgtgctgg aaaaccacca tctggccgtg ggcttcaagc tgctgcagga agaacactgc      960

gacatctttc agaacctgac caagaagcag aggcagaccc tgagaaagat ggtcatcgac     1020

atggtgctgg ccaccgacat gagcaagcac atgtccctgc tggccgacct gaaaaccatg     1080

gtggaaacaa agaaagtgac cagctccggc gtgctgctgc tggacaacta caccgacaga     1140

atccaggtgc tgaggaacat ggtgcactgc gccgacctgt ccaaccccac caagagcctg     1200

gaactgtaca gacagtggac cgacaggatc atggaagagt tctttcagca aggcgacaaa     1260

gaacgcgaga ggggcatgga aatcagcccc atgtgcgaca agcacaccgc cagcgtggaa     1320

aagtcccaag tgggctttat cgactacatc gtgcaccccc tgtgggagac atgggccgat     1380

ctggtgcagc ctgacgccca ggacatcctg gacactctgg aagataaccg gaactggtat     1440

cagagcatga tcccccagag ccccagccct ccactggacg agagatccag agactgccag     1500

ggcctgatgg aaaagttcca gttcgagctg actctggaag aagaggacag cgagggcccc     1560

gagaaagaag gcgagggcca ctcttacttc agcagcacca agacactgtg cgtgatcgac     1620

cccgagaaca gggacagcct cgaagagact gacatcgaca ttgccaccga ggacaagagc     1680

cccatcgata ca                                                         1692


<210> 31
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 31
gccacc                                                                   6


<210> 32
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Asp Gly Gly Gly 
1               


<210> 33
<211> 53
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
            20                  25                  30          


Thr Gly Ser Gly Ser Gly Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu 
        35                  40                  45              


Gly Leu Asp Ser Thr 
    50              


<210> 34
<211> 144
<212> PRT
<213> Homo sapiens

<400> 34
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 35
<211> 432
<212> DNA
<213> Homo sapiens

<400> 35
atgtggctgc aatctctgct gctgctgggc acagtggcct gttctattag cgcccctgcc       60

agatctccat ctcctagcac acagccttgg gagcacgtga acgccatcca agaagccaga      120

cggctgctga acctgagcag agatacagcc gccgagatga acgagacagt ggaagtgatc      180

agcgagatgt tcgacctgca agagcctacc tgcctgcaga ccagactgga actgtacaag      240

cagggcctga gaggcagcct gaccaagctg aaaggccctc tgacaatgat ggccagccac      300

tacaagcagc actgccctcc aacacctgag acaagctgtg ccacacagat catcaccttc      360

gagagcttca aagagaacct gaaggacttc ctgctggtca tccccttcga ctgctgggag      420

cccgtgcaag aa                                                          432


<210> 36
<211> 127
<212> PRT
<213> Homo sapiens

<400> 36
Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210> 37
<211> 381
<212> DNA
<213> Homo sapiens

<400> 37
gcccctgcca gatctccatc tcctagcaca cagccttggg agcacgtgaa cgccatccaa       60

gaagccagac ggctgctgaa cctgagcaga gatacagccg ccgagatgaa cgagacagtg      120

gaagtgatca gcgagatgtt cgacctgcaa gagcctacct gcctgcagac cagactggaa      180

ctgtacaagc agggcctgag aggcagcctg accaagctga aaggccctct gacaatgatg      240

gccagccact acaagcagca ctgccctcca acacctgaga caagctgtgc cacacagatc      300

atcaccttcg agagcttcaa agagaacctg aaggacttcc tgctggtcat ccccttcgac      360

tgctgggagc ccgtgcaaga a                                                381


<210> 38
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      WT TCR (BC 1) sequence"

<400> 38
Gln Ser Ser Gln 
1               


<210> 39
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Gln Thr Ser Gln 
1               


<210> 40
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Gln Ser Thr Gln 
1               


<210> 41
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Gln Ser Asn Gln 
1               


<210> 42
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Gln Ser Ser Trp 
1               


<210> 43
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Gln Ser Ser Gln 
1               


<210> 44
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      WT TCR (BC 1) sequence"

<400> 44
Gln Thr Gly Gly 
1               


<210> 45
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Gln Thr Gly Gly 
1               


<210> 46
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Gln Glu Gly Gly 
1               


<210> 47
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Gln Tyr Gly Gly 
1               


<210> 48
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Gln Thr Gly Ala 
1               


<210> 49
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Gln Thr Gly Ser 
1               


<210> 50
<211> 7
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      WT TCR (BC 1) sequence"

<400> 50
Val Gly Ala Gly Ile Thr Asp 
1               5           


<210> 51
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Val Gly Ala Gly Ile Thr Asp 
1               5           


<210> 52
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Val Val Ala Gly Ile Thr Asp 
1               5           


<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Val Gly Asp Gly Ile Thr Asp 
1               5           


<210> 54
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Val Ala Asp Gly Ile Thr Asp 
1               5           


<210> 55
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Val Gly Ala Gln Ile Thr Asp 
1               5           


<210> 56
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Val Gly Ala Gly Phe Thr Asp 
1               5           


<210> 57
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Val Gly Ala Gly Trp Thr Asp 
1               5           


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Val Gly Ala Gly Glu Thr Asp 
1               5           


<210> 59
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Val Gly Ala Gly Ile Thr Glu 
1               5           


<210> 60
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Val Ala Glu Gly Ile Thr Asp 
1               5           


<210> 61
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      WT TCR (BC 1) sequence"

<400> 61
Tyr Val Gly Ala 
1               


<210> 62
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
Tyr Val Gly Ala 
1               


<210> 63
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Asn Val Gly Ala 
1               


<210> 64
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Tyr Leu Gly Ala 
1               


<210> 65
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 65
Tyr Ile Gly Ala 
1               


<210> 66
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Tyr Val Ser Ala 
1               


<210> 67
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 67
Tyr Val Gly Val 
1               


<210> 68
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 68
Tyr Val Gly Ile 
1               


<210> 69
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 69
Tyr Val Gly Leu 
1               


<210> 70
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 70
Tyr Val Gly Asp 
1               


<210> 71
<211> 8
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      WT (Lau155 BV13c1) 'BC1' sequence"

<400> 71
Ser Val Gly Ala Gly Ile Thr Asp 
1               5               


<210> 72
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 72
Ser Val Gly Ala Gly Ile Thr Asp 
1               5               


<210> 73
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Ser Val Gly Ala Gly Glu Thr Asp 
1               5               


<210> 74
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 74
Ser Val Gly Ala Gly Phe Thr Asp 
1               5               


<210> 75
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 75
Ser Val Gly Ala Gly Trp Thr Asp 
1               5               


<210> 76
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 76
Ser Val Gly Ala Gly Ile Thr Glu 
1               5               


<210> 77
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 77
Ser Val Ala Glu Gly Ile Thr Asp 
1               5               


<210> 78
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      WT (Lau155 BV13c1) 'BC1' sequence"

<400> 78
Gly Ala Ala Gly 
1               


<210> 79
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 79
Gly Leu Ala Gly 
1               


<210> 80
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 80
Gly Ala Ala Gly 
1               


<210> 81
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 81
Gly Asn Thr Gly 
1               


<210> 82
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 82
Gly Leu Tyr Gly 
1               


