                         SEQUENCE LISTING

<110>  Institute for Research in Biomedicine
 
<120>  PEPTIDE INHIBITORS TARGETING THE CXCL12/HMGB1 INTERACTION AND 
       USES THEREOF

<130>  IR01P011WO1

<150>  PCT/EP2019/057125
<151>  2019-03-21

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08

<400>  1

Gly Tyr His Tyr Glu Arg Trp Ile His 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP07

<400>  2

His Trp Thr Leu Ala Asn Trp Cys Arg 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP05

<400>  3

Trp Ile Ser Asn Trp Ile Leu Met Trp 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP12

<400>  4

Tyr His Ile Cys Trp Tyr Gly Asp Tyr 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP01

<400>  5

His Glu Met Tyr Trp Glu Asp Glu Trp 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP02

<400>  6

Ile Asp Leu Arg Phe Phe Met Arg Gln 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP03

<400>  7

Phe Ala Phe Glu Leu Ile Gln Thr Asp 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP04

<400>  8

Cys Ile Pro Met Met Met His Ala Trp 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP06

<400>  9

Thr Trp Asn Ile His Phe Ala Asp His 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP09

<400>  10

Gln Phe Met Lys Asn Cys Glu Glu Met 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP10

<400>  11

Ser Ile Asn Trp His Met Tyr Val Asn 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP11

<400>  12

Met Tyr Arg Glu Asn Gln Pro Thr Arg 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP13

<400>  13

Trp Leu Trp Tyr Glu Trp Gly Trp Gln 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  14

Asp Tyr Cys Trp Lys Ile Met Thr Gln 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  15

Trp Cys His Phe Phe Phe Pro His Trp 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  16

Met Lys Ser Ser Asp Cys Cys Leu Glu 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  17

Glu Trp Phe Val Met Lys His Leu Asn 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  18

Met Ile Arg Asp Gln Ile Leu His Asn 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  19

Trp His Gln Leu Thr Glu His Trp Ile 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  20

His Asp His Asp Phe Trp Ala Trp Tyr 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  21

Trp Gln Trp His Gln Phe Gln Gly Arg 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  22

Val Met Ala Ser Trp Gln His Gly Leu 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  23

Leu Asp Asn Phe Leu Gly Asp His Trp 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  24

Pro Arg Met Gly Trp Glu Lys Pro Glu 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  25

Trp Ile Cys Val Trp His His Ala Ser 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  26

Ile Arg Trp Cys Val Asp Ala Arg Tyr 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  27

Trp Asn Ala Met Ser Phe Cys Cys Ser 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  28

Ile Phe His Ile Met Thr Glu Met Trp 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  29

Phe Asp Arg Pro Arg Tyr Arg Thr Thr 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  30

Gln Ile Glu Asp Met Pro Thr Ser Lys 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  31

Phe Asp Cys Met Met Asp Met Thr Lys 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  32

Asn Thr Val Ala Leu Lys Leu Arg Asp 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  33

Tyr His Tyr His Met Leu Met Gln Ser 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  34

Asn Ile Thr His Asn Val Trp His Arg 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  35

Asp Arg Asn Leu Glu Val Glu Gln Ile 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  36

His Tyr Asn Lys Trp Lys His Gln Glu 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  37

Ile Cys Met Pro Pro Asn Thr Lys Asn 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  38

Ser Met Ile Pro Val Gln Glu Ala Ser 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  39

Tyr Gln Arg Asn Glu Leu Glu Tyr Leu 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  40

His Tyr Phe Asp Met Leu His Phe His 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  41

Ser His Tyr Phe Lys His Ser Asn Phe 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  42

Phe Ile Lys Gln Met Glu Glu Ser Thr 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  43

Lys Tyr Gln Trp Met His Tyr Thr Pro 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-RI


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  all D-amino acids

<400>  44

His Ile Trp Arg Glu Tyr His Tyr Gly 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-A1

<400>  45

Ala Tyr His Tyr Glu Arg Trp Ile His 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-A2

<400>  46

Gly Ala His Tyr Glu Arg Trp Ile His 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-A3

<400>  47

Gly Tyr Ala Tyr Glu Arg Trp Ile His 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-A4

<400>  48

Gly Tyr His Ala Glu Arg Trp Ile His 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-A5

<400>  49

Gly Tyr His Tyr Ala Arg Trp Ile His 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-A6

<400>  50

Gly Tyr His Tyr Glu Ala Trp Ile His 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-A7

<400>  51

Gly Tyr His Tyr Glu Arg Ala Ile His 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-A8

<400>  52

Gly Tyr His Tyr Glu Arg Trp Ala His 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-A9

<400>  53

Gly Tyr His Tyr Glu Arg Trp Ile Ala 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-D2

<400>  54

Gly Asp His Tyr Glu Arg Trp Ile His 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-K9

<400>  55

Gly Tyr His Tyr Glu Arg Trp Ile Lys 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP08-K2

<400>  56

Gly Lys His Tyr Glu Arg Trp Ile His 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XHBP08

<400>  57

His Tyr Trp Tyr Glu Arg Trp Glu His 
1               5                   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pentapept-2

<400>  58

Glu Arg Trp Ile His 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pentapept-1

<400>  59

Gly Tyr His Tyr Glu 
1               5   


<210>  60
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  61

Phe Val Gly Met Arg Trp Lys Phe Leu 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  62

Trp Gln Ile Pro Asp His Arg Asp His 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  63

Gln Cys Phe His Pro Ser Phe Glu Asp 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  64

Val Pro Ser Ser Ala Lys Asn Arg Asp 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  65

Lys His Met Thr Lys Cys Glu Gln Trp 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  66

Glu Thr Tyr Gln Phe Arg Pro Asn Lys 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  67

Trp Asn Cys His Arg Asp Arg Pro Lys 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  68

Lys His Met Thr Lys Cys Glu Gln Trp 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  69

Lys Cys Val Val Phe His Tyr Asp Pro 
1               5                   


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  70

Pro Thr Phe Glu Glu Phe Ala Ala Phe 
1               5                   


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  71

Gln Cys Phe His Pro Ser Phe Glu Asp 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  72

Glu Trp Leu Tyr Arg Gln Glu Tyr His 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  73

Gln Asp Tyr Ala Pro Arg Ala Ser Asn 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  74

Lys Asp Lys Ala Phe Lys Asn Val Ser 
1               5                   


