                         SEQUENCE LISTING

<110>  Centre national de la recherche scientifique (CNRS)
       Institut national de la sant et de la recherche (INSERM)
       Universit de Strasbourg (UNISTRA)
 
<120>  Compositions and methods for the treatment of  Autosomal Dominant
        Centronuclear Myopathy

<130>  B3224PC00

<150>  US 62820932
<151>  2019-03-20

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  1782
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcagaga tgggcagtaa aggggtgacg gcgggaaaga tcgccagcaa cgtgcagaag       60

aagctcaccc gcgcgcagga gaaggttctc cagaagctgg ggaaggcaga tgagaccaag      120

gatgagcagt ttgagcagtg cgtccagaat ttcaacaagc agctgacgga gggcacccgg      180

ctgcagaagg atctccggac ctacctggcc tccgtcaaag ccatgcacga ggcttccaag      240

aagctgaatg agtgtctgca ggaggtgtat gagcccgatt ggcccggcag ggatgaggca      300

aacaagatcg cagagaacaa cgacctgctg tggatggatt accaccagaa gctggtggac      360

caggcgctgc tgaccatgga cacgtacctg ggccagttcc ccgacatcaa gtcacgcatt      420

gccaagcggg ggcgcaagct ggtggactac gacagtgccc ggcaccacta cgagtccctt      480

caaactgcca aaaagaagga tgaagccaaa attgccaagc ctgtctcgct gcttgagaaa      540

gccgcccccc agtggtgcca aggcaaactg caggctcatc tcgtagctca aactaacctg      600

ctccgaaatc aggccgagga ggagctcatc aaagcccaga aggtgtttga ggagatgaat      660

gtggatctgc aggaggagct gccgtccctg tggaacagcc gcgtaggttt ctacgtcaac      720

acgttccaga gcatcgcggg cctggaggaa aacttccaca aggagatgag caagctcaac      780

cagaacctca atgatgtgct ggtcggcctg gagaagcaac acgggagcaa caccttcacg      840

gtcaaggccc agcccagtga caacgcgcct gcaaaaggga acaagagccc ttcgcctcca      900

gatggctccc ctgccgccac ccccgagatc agagtcaacc acgagccaga gccggccggc      960

ggggccacgc ccggggccac cctccccaag tccccatctc agctccggaa aggcccacca     1020

gtccctccgc ctcccaaaca caccccgtcc aaggaagtca agcaggagca gatcctcagc     1080

ctgtttgagg acacgtttgt ccctgagatc agcgtgacca ccccctccca gtttgaggcc     1140

ccggggcctt tctcggagca ggccagtctg ctggacctgg actttgaccc cctcccgccc     1200

gtgacgagcc ctgtgaaggc acccacgccc tctggtcagt caattccatg ggacctctgg     1260

gagcccacag agagtccagc cggcagcctg ccttccgggg agcccagcgc tgccgagggc     1320

acctttgctg tgtcctggcc cagccagacg gccgagccgg ggcctgccca accagcagag     1380

gcctcggagg tggcgggtgg gacccaacct gcggctggag cccaggagcc aggggagacg     1440

gcggcaagtg aagcagcctc cagctctctt cctgctgtcg tggtggagac cttcccagca     1500

actgtgaatg gcaccgtgga gggcggcagt ggggccgggc gcttggacct gcccccaggt     1560

ttcatgttca aggtacaggc ccagcacgac tacacggcca ctgacacaga cgagctgcag     1620

ctcaaggctg gtgatgtggt gctggtgatc cccttccaga accctgaaga gcaggatgaa     1680

ggctggctca tgggcgtgaa ggagagcgac tggaaccagc acaaggagct ggagaagtgc     1740

cgtggcgtct tccccgagaa cttcactgag agggtcccat ga                        1782


<210>  2
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
1               5                   10                  15      


Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
            20                  25                  30          


Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
        35                  40                  45              


Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
    50                  55                  60                  


Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                85                  90                  95      


Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
            100                 105                 110         


Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
        115                 120                 125             


Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
    130                 135                 140                 


Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
145                 150                 155                 160 


Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Pro Val Ser 
                165                 170                 175     


Leu Leu Glu Lys Ala Ala Pro Gln Trp Cys Gln Gly Lys Leu Gln Ala 
            180                 185                 190         


His Leu Val Ala Gln Thr Asn Leu Leu Arg Asn Gln Ala Glu Glu Glu 
        195                 200                 205             


Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu Gln 
    210                 215                 220                 


Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val Asn 
225                 230                 235                 240 


Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu Met 
                245                 250                 255     


Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu Lys 
            260                 265                 270         


Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp Asn 
        275                 280                 285             


Ala Pro Ala Lys Gly Asn Lys Ser Pro Ser Pro Pro Asp Gly Ser Pro 
    290                 295                 300                 


Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala Gly 
305                 310                 315                 320 


Gly Ala Thr Pro Gly Ala Thr Leu Pro Lys Ser Pro Ser Gln Leu Arg 
                325                 330                 335     


Lys Gly Pro Pro Val Pro Pro Pro Pro Lys His Thr Pro Ser Lys Glu 
            340                 345                 350         


Val Lys Gln Glu Gln Ile Leu Ser Leu Phe Glu Asp Thr Phe Val Pro 
        355                 360                 365             


Glu Ile Ser Val Thr Thr Pro Ser Gln Phe Glu Ala Pro Gly Pro Phe 
    370                 375                 380                 


Ser Glu Gln Ala Ser Leu Leu Asp Leu Asp Phe Asp Pro Leu Pro Pro 
385                 390                 395                 400 


Val Thr Ser Pro Val Lys Ala Pro Thr Pro Ser Gly Gln Ser Ile Pro 
                405                 410                 415     


Trp Asp Leu Trp Glu Pro Thr Glu Ser Pro Ala Gly Ser Leu Pro Ser 
            420                 425                 430         


Gly Glu Pro Ser Ala Ala Glu Gly Thr Phe Ala Val Ser Trp Pro Ser 
        435                 440                 445             


Gln Thr Ala Glu Pro Gly Pro Ala Gln Pro Ala Glu Ala Ser Glu Val 
    450                 455                 460                 


Ala Gly Gly Thr Gln Pro Ala Ala Gly Ala Gln Glu Pro Gly Glu Thr 
465                 470                 475                 480 


Ala Ala Ser Glu Ala Ala Ser Ser Ser Leu Pro Ala Val Val Val Glu 
                485                 490                 495     


Thr Phe Pro Ala Thr Val Asn Gly Thr Val Glu Gly Gly Ser Gly Ala 
            500                 505                 510         


Gly Arg Leu Asp Leu Pro Pro Gly Phe Met Phe Lys Val Gln Ala Gln 
        515                 520                 525             


His Asp Tyr Thr Ala Thr Asp Thr Asp Glu Leu Gln Leu Lys Ala Gly 
    530                 535                 540                 


Asp Val Val Leu Val Ile Pro Phe Gln Asn Pro Glu Glu Gln Asp Glu 
545                 550                 555                 560 


Gly Trp Leu Met Gly Val Lys Glu Ser Asp Trp Asn Gln His Lys Glu 
                565                 570                 575     


Leu Glu Lys Cys Arg Gly Val Phe Pro Glu Asn Phe Thr Glu Arg Val 
            580                 585                 590         


Pro 
    


<210>  3
<211>  84
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcagaga tgggcagtaa aggggtgacg gcgggaaaga tcgccagcaa cgtgcagaag       60

aagctcaccc gcgcgcagga gaag                                              84


<210>  4
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  4
gttctccaga agctggggaa ggcagatgag accaaggatg agcagtttga gcagtgcgtc       60

cagaatttca acaagcagct g                                                 81


<210>  5
<211>  55
<212>  DNA
<213>  Homo sapiens

<400>  5
acggagggca cccggctgca gaaggatctc cggacctacc tggcctccgt caaag            55


<210>  6
<211>  95
<212>  DNA
<213>  Homo sapiens

<400>  6
ccatgcacga ggcttccaag aagctgaatg agtgtctgca ggaggtgtat gagcccgatt       60

ggcccggcag ggatgaggca aacaagatcg cagag                                  95


<210>  7
<211>  96
<212>  DNA
<213>  Homo sapiens

<400>  7
aacaacgacc tgctgtggat ggattaccac cagaagctgg tggaccaggc gctgctgacc       60

atggacacgt acctgggcca gttccccgac atcaag                                 96


<210>  8
<211>  108
<212>  DNA
<213>  Homo sapiens

<400>  8
tcacgcattg ccaagcgggg gcgcaagctg gtggactacg acagtgcccg gcaccactac       60

gagtcccttc aaactgccaa aaagaaggat gaagccaaaa ttgccaag                   108


<210>  9
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  9
cctgtctcgc tgcttgagaa agccgccccc cagtggtgcc aaggcaaact gcaggctcat       60

ctcgtagctc aaactaacct gctccgaaat cag                                    93


<210>  10
<211>  86
<212>  DNA
<213>  Homo sapiens

<400>  10
gccgaggagg agctcatcaa agcccagaag gtgtttgagg agatgaatgt ggatctgcag       60

gaggagctgc cgtccctgtg gaacag                                            86


<210>  11
<211>  76
<212>  DNA
<213>  Homo sapiens

<400>  11
ccgcgtaggt ttctacgtca acacgttcca gagcatcgcg ggcctggagg aaaacttcca       60

caaggagatg agcaag                                                       76


<210>  12
<211>  83
<212>  DNA
<213>  Homo sapiens

<400>  12
ctcaaccaga acctcaatga tgtgctggtc ggcctggaga agcaacacgg gagcaacacc       60

ttcacggtca aggcccagcc cag                                               83


<210>  13
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  13
aaagaaaagt aaactgtttt cgcggctgcg cagaaagaag aacag                       45


<210>  14
<211>  145
<212>  DNA
<213>  Homo sapiens

<400>  14
tgacaacgcg cctgcaaaag ggaacaagag cccttcgcct ccagatggct cccctgccgc       60

cacccccgag atcagagtca accacgagcc agagccggcc ggcggggcca cgcccggggc      120

caccctcccc aagtccccat ctcag                                            145


<210>  15
<211>  129
<212>  DNA
<213>  Homo sapiens

<400>  15
ctccggaaag gcccaccagt ccctccgcct cccaaacaca ccccgtccaa ggaagtcaag       60

caggagcaga tcctcagcct gtttgaggac acgtttgtcc ctgagatcag cgtgaccacc      120

ccctcccag                                                              129


<210>  16
<211>  108
<212>  DNA
<213>  Homo sapiens

<400>  16
tttgaggccc cggggccttt ctcggagcag gccagtctgc tggacctgga ctttgacccc       60

ctcccgcccg tgacgagccc tgtgaaggca cccacgccct ctggtcag                   108


<210>  17
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  17
tcaattccat gggacctctg ggag                                              24


<210>  18
<211>  108
<212>  DNA
<213>  Homo sapiens

<400>  18
cccacagaga gtccagccgg cagcctgcct tccggggagc ccagcgctgc cgagggcacc       60

tttgctgtgt cctggcccag ccagacggcc gagccggggc ctgcccaa                   108


<210>  19
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  19
ccagcagagg cctcggaggt ggcgggtggg acccaacctg cggctggagc ccaggagcca       60

ggggagacgg cggcaagtga agcagcctcc                                        90


<210>  20
<211>  111
<212>  DNA
<213>  Homo sapiens

<400>  20
agctctcttc ctgctgtcgt ggtggagacc ttcccagcaa ctgtgaatgg caccgtggag       60

ggcggcagtg gggccgggcg cttggacctg cccccaggtt tcatgttcaa g               111


<210>  21
<211>  102
<212>  DNA
<213>  Homo sapiens

<400>  21
gtacaggccc agcacgacta cacggccact gacacagacg agctgcagct caaggctggt       60

gatgtggtgc tggtgatccc cttccagaac cctgaagagc ag                         102


<210>  22
<211>  108
<212>  DNA
<213>  Homo sapiens

<400>  22
gatgaaggct ggctcatggg cgtgaaggag agcgactgga accagcacaa ggagctggag       60

aagtgccgtg gcgtcttccc cgagaacttc actgagaggg tcccatga                   108


<210>  23
<211>  809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial cDNA sequence with exons 1 to 6 and 8 to 11

<400>  23
atggcagaga tgggcagtaa aggggtgacg gcgggaaaga tcgccagcaa cgtgcagaag       60

aagctcaccc gcgcgcagga gaaggttctc cagaagctgg ggaaggcaga tgagaccaag      120

gatgagcagt ttgagcagtg cgtccagaat ttcaacaagc agctgacgga gggcacccgg      180

ctgcagaagg atctccggac ctacctggcc tccgtcaaag ccatgcacga ggcttccaag      240

aagctgaatg agtgtctgca ggaggtgtat gagcccgatt ggcccggcag ggatgaggca      300

aacaagatcg cagagaacaa cgacctgctg tggatggatt accaccagaa gctggtggac      360

caggcgctgc tgaccatgga cacgtacctg ggccagttcc ccgacatcaa gtcacgcatt      420

gccaagcggg ggcgcaagct ggtggactac gacagtgccc ggcaccacta cgagtccctt      480

caaactgcca aaaagaagga tgaagccaaa attgccaagg ccgaggagga gctcatcaaa      540

gcccagaagg tgtttgagga gatgaatgtg gatctgcagg aggagctgcc gtccctgtgg      600

aacagccgcg taggtttcta cgtcaacacg ttccagagca tcgcgggcct ggaggaaaac      660

ttccacaagg agatgagcaa gctcaaccag aacctcaatg atgtgctggt cggcctggag      720

aagcaacacg ggagcaacac cttcacggtc aaggcccagc ccagaaagaa aagtaaactg      780

ttttcgcggc tgcgcagaaa gaagaacag                                        809


<210>  24
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMINO ACID SEQUENCE corresponding to artificial cDNA sequence 
       with exons 1 to 6 and 8 to 11

<400>  24

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
1               5                   10                  15      


Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
            20                  25                  30          


Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
        35                  40                  45              


Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
    50                  55                  60                  


Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                85                  90                  95      


Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
            100                 105                 110         


Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
        115                 120                 125             


Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
    130                 135                 140                 


Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
145                 150                 155                 160 


Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Ala Glu Glu 
                165                 170                 175     


Glu Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu 
            180                 185                 190         


Gln Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val 
        195                 200                 205             


Asn Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu 
    210                 215                 220                 


Met Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu 
225                 230                 235                 240 


Lys Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Arg Lys 
                245                 250                 255     


Lys Ser Lys Leu Phe Ser Arg Leu Arg Arg Lys Lys Asn Ser 
            260                 265                 270 


<210>  25
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  25
atggcagaga tgggcagtaa aggggtgacg gcgggaaaga tcgccagcaa cgtgcagaag       60

aagctcaccc gcgcgcagga gaaggttctc cagaagctgg ggaaggcaga tgagaccaag      120

gatgagcagt ttgagcagtg cgtccagaat ttcaacaagc agctgacgga gggcacccgg      180

ctgcagaagg atctccggac ctacctggcc tccgtcaaag ccatgcacga ggcttccaag      240

aagctgaatg agtgtctgca ggaggtgtat gagcccgatt ggcccggcag ggatgaggca      300

aacaagatcg cagagaacaa cgacctgctg tggatggatt accaccagaa gctggtggac      360

caggcgctgc tgaccatgga cacgtacctg ggccagttcc ccgacatcaa gtcacgcatt      420

gccaagcggg ggcgcaagct ggtggactac gacagtgccc ggcaccacta cgagtccctt      480

caaactgcca aaaagaagga tgaagccaaa attgccaagg ccgaggagga gctcatcaaa      540

gcccagaagg tgtttgagga gatgaatgtg gatctgcagg aggagctgcc gtccctgtgg      600

aacagccgcg taggtttcta cgtcaacacg ttccagagca tcgcgggcct ggaggaaaac      660

ttccacaagg agatgagcaa gctcaaccag aacctcaatg atgtgctggt cggcctggag      720

aagcaacacg ggagcaacac cttcacggtc aaggcccagc ccagtgacaa cgcgcctgca      780

aaagggaaca agagcccttc gcctccagat ggctcccctg ccgccacccc cgagatcaga      840

gtcaaccacg agccagagcc ggccggcggg gccacgcccg gggccaccct ccccaagtcc      900

ccatctcagc cagcagaggc ctcggaggtg gcgggtggga cccaacctgc ggctggagcc      960

caggagccag gggagacggc ggcaagtgaa gcagcctcca gctctcttcc tgctgtcgtg     1020

gtggagacct tcccagcaac tgtgaatggc accgtggagg gcggcagtgg ggccgggcgc     1080

ttggacctgc ccccaggttt catgttcaag gtacaggccc agcacgacta cacggccact     1140

gacacagacg agctgcagct caaggctggt gatgtggtgc tggtgatccc cttccagaac     1200

cctgaagagc aggatgaagg ctggctcatg ggcgtgaagg agagcgactg gaaccagcac     1260

aaggagctgg agaagtgccg tggcgtcttc cccgagaact tcactgagag ggtcccatga     1320


<210>  26
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
1               5                   10                  15      


Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
            20                  25                  30          


Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
        35                  40                  45              


Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
    50                  55                  60                  


Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                85                  90                  95      


Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
            100                 105                 110         


Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
        115                 120                 125             


Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
    130                 135                 140                 


Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
145                 150                 155                 160 


Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Ala Glu Glu 
                165                 170                 175     


Glu Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu 
            180                 185                 190         


Gln Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val 
        195                 200                 205             


Asn Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu 
    210                 215                 220                 


Met Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu 
225                 230                 235                 240 


Lys Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp 
                245                 250                 255     


Asn Ala Pro Ala Lys Gly Asn Lys Ser Pro Ser Pro Pro Asp Gly Ser 
            260                 265                 270         


Pro Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala 
        275                 280                 285             


Gly Gly Ala Thr Pro Gly Ala Thr Leu Pro Lys Ser Pro Ser Gln Pro 
    290                 295                 300                 


Ala Glu Ala Ser Glu Val Ala Gly Gly Thr Gln Pro Ala Ala Gly Ala 
305                 310                 315                 320 


Gln Glu Pro Gly Glu Thr Ala Ala Ser Glu Ala Ala Ser Ser Ser Leu 
                325                 330                 335     


Pro Ala Val Val Val Glu Thr Phe Pro Ala Thr Val Asn Gly Thr Val 
            340                 345                 350         


Glu Gly Gly Ser Gly Ala Gly Arg Leu Asp Leu Pro Pro Gly Phe Met 
        355                 360                 365             


Phe Lys Val Gln Ala Gln His Asp Tyr Thr Ala Thr Asp Thr Asp Glu 
    370                 375                 380                 


Leu Gln Leu Lys Ala Gly Asp Val Val Leu Val Ile Pro Phe Gln Asn 
385                 390                 395                 400 


Pro Glu Glu Gln Asp Glu Gly Trp Leu Met Gly Val Lys Glu Ser Asp 
                405                 410                 415     


Trp Asn Gln His Lys Glu Leu Glu Lys Cys Arg Gly Val Phe Pro Glu 
            420                 425                 430         


Asn Phe Thr Glu Arg Val Pro 
        435                 


<210>  27
<211>  1275
<212>  DNA
<213>  Homo sapiens

<400>  27
atggcagaga tgggcagtaa aggggtgacg gcgggaaaga tcgccagcaa cgtgcagaag       60

aagctcaccc gcgcgcagga gaaggttctc cagaagctgg ggaaggcaga tgagaccaag      120

gatgagcagt ttgagcagtg cgtccagaat ttcaacaagc agctgacgga gggcacccgg      180

ctgcagaagg atctccggac ctacctggcc tccgtcaaag ccatgcacga ggcttccaag      240

aagctgaatg agtgtctgca ggaggtgtat gagcccgatt ggcccggcag ggatgaggca      300

aacaagatcg cagagaacaa cgacctgctg tggatggatt accaccagaa gctggtggac      360

caggcgctgc tgaccatgga cacgtacctg ggccagttcc ccgacatcaa gtcacgcatt      420

gccaagcggg ggcgcaagct ggtggactac gacagtgccc ggcaccacta cgagtccctt      480

caaactgcca aaaagaagga tgaagccaaa attgccaagg ccgaggagga gctcatcaaa      540

gcccagaagg tgtttgagga gatgaatgtg gatctgcagg aggagctgcc gtccctgtgg      600

aacagccgcg taggtttcta cgtcaacacg ttccagagca tcgcgggcct ggaggaaaac      660

ttccacaagg agatgagcaa gctcaaccag aacctcaatg atgtgctggt cggcctggag      720

aagcaacacg ggagcaacac cttcacggtc aaggcccagc ccagaaagaa aagtaaactg      780

ttttcgcggc tgcgcagaaa gaagaacagt gacaacgcgc ctgcaaaagg gaacaagagc      840

ccttcgcctc cagatggctc ccctgccgcc acccccgaga tcagagtcaa ccacgagcca      900

gagccggccg gcggggccac gcccggggcc accctcccca agtccccatc tcagagctct      960

cttcctgctg tcgtggtgga gaccttccca gcaactgtga atggcaccgt ggagggcggc     1020

agtggggccg ggcgcttgga cctgccccca ggtttcatgt tcaaggtaca ggcccagcac     1080

gactacacgg ccactgacac agacgagctg cagctcaagg ctggtgatgt ggtgctggtg     1140

atccccttcc agaaccctga agagcaggat gaaggctggc tcatgggcgt gaaggagagc     1200

gactggaacc agcacaagga gctggagaag tgccgtggcg tcttccccga gaacttcact     1260

gagagggtcc catga                                                      1275


<210>  28
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
1               5                   10                  15      


Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
            20                  25                  30          


Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
        35                  40                  45              


Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
    50                  55                  60                  


Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                85                  90                  95      


Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
            100                 105                 110         


Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
        115                 120                 125             


Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
    130                 135                 140                 


Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
145                 150                 155                 160 


Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Ala Glu Glu 
                165                 170                 175     


Glu Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu 
            180                 185                 190         


Gln Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val 
        195                 200                 205             


Asn Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu 
    210                 215                 220                 


Met Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu 
225                 230                 235                 240 


Lys Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Arg Lys 
                245                 250                 255     


Lys Ser Lys Leu Phe Ser Arg Leu Arg Arg Lys Lys Asn Ser Asp Asn 
            260                 265                 270         


Ala Pro Ala Lys Gly Asn Lys Ser Pro Ser Pro Pro Asp Gly Ser Pro 
        275                 280                 285             


Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala Gly 
    290                 295                 300                 


Gly Ala Thr Pro Gly Ala Thr Leu Pro Lys Ser Pro Ser Gln Ser Ser 
305                 310                 315                 320 


Leu Pro Ala Val Val Val Glu Thr Phe Pro Ala Thr Val Asn Gly Thr 
                325                 330                 335     


Val Glu Gly Gly Ser Gly Ala Gly Arg Leu Asp Leu Pro Pro Gly Phe 
            340                 345                 350         


Met Phe Lys Val Gln Ala Gln His Asp Tyr Thr Ala Thr Asp Thr Asp 
        355                 360                 365             


Glu Leu Gln Leu Lys Ala Gly Asp Val Val Leu Val Ile Pro Phe Gln 
    370                 375                 380                 


Asn Pro Glu Glu Gln Asp Glu Gly Trp Leu Met Gly Val Lys Glu Ser 
385                 390                 395                 400 


Asp Trp Asn Gln His Lys Glu Leu Glu Lys Cys Arg Gly Val Phe Pro 
                405                 410                 415     


Glu Asn Phe Thr Glu Arg Val Pro 
            420                 


<210>  29
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  29
atggcagaga tgggcagtaa aggggtgacg gcgggaaaga tcgccagcaa cgtgcagaag       60

aagctcaccc gcgcgcagga gaaggttctc cagaagctgg ggaaggcaga tgagaccaag      120

gatgagcagt ttgagcagtg cgtccagaat ttcaacaagc agctgacgga gggcacccgg      180

ctgcagaagg atctccggac ctacctggcc tccgtcaaag ccatgcacga ggcttccaag      240

aagctgaatg agtgtctgca ggaggtgtat gagcccgatt ggcccggcag ggatgaggca      300

aacaagatcg cagagaacaa cgacctgctg tggatggatt accaccagaa gctggtggac      360

caggcgctgc tgaccatgga cacgtacctg ggccagttcc ccgacatcaa gtcacgcatt      420

gccaagcggg ggcgcaagct ggtggactac gacagtgccc ggcaccacta cgagtccctt      480

caaactgcca aaaagaagga tgaagccaaa attgccaagg ccgaggagga gctcatcaaa      540

gcccagaagg tgtttgagga gatgaatgtg gatctgcagg aggagctgcc gtccctgtgg      600

aacagccgcg taggtttcta cgtcaacacg ttccagagca tcgcgggcct ggaggaaaac      660

ttccacaagg agatgagcaa gctcaaccag aacctcaatg atgtgctggt cggcctggag      720

aagcaacacg ggagcaacac cttcacggtc aaggcccagc ccagaaagaa aagtaaactg      780

ttttcgcggc tgcgcagaaa gaagaacagt gacaacgcgc ctgcaaaagg gaacaagagc      840

ccttcgcctc cagatggctc ccctgccgcc acccccgaga tcagagtcaa ccacgagcca      900

gagccggccg gcggggccac gcccggggcc accctcccca agtccccatc tcagccagca      960

gaggcctcgg aggtggcggg tgggacccaa cctgcggctg gagcccagga gccaggggag     1020

acggcggcaa gtgaagcagc ctccagctct cttcctgctg tcgtggtgga gaccttccca     1080

gcaactgtga atggcaccgt ggagggcggc agtggggccg ggcgcttgga cctgccccca     1140

ggtttcatgt tcaaggtaca ggcccagcac gactacacgg ccactgacac agacgagctg     1200

cagctcaagg ctggtgatgt ggtgctggtg atccccttcc agaaccctga agagcaggat     1260

gaaggctggc tcatgggcgt gaaggagagc gactggaacc agcacaagga gctggagaag     1320

tgccgtggcg tcttccccga gaacttcact gagagggtcc catga                     1365


<210>  30
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
1               5                   10                  15      


Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
            20                  25                  30          


Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
        35                  40                  45              


Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
    50                  55                  60                  


Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                85                  90                  95      


Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
            100                 105                 110         


Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
        115                 120                 125             


Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
    130                 135                 140                 


Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
145                 150                 155                 160 


Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Ala Glu Glu 
                165                 170                 175     


Glu Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu 
            180                 185                 190         


Gln Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val 
        195                 200                 205             


Asn Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu 
    210                 215                 220                 


Met Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu 
225                 230                 235                 240 


Lys Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Arg Lys 
                245                 250                 255     


Lys Ser Lys Leu Phe Ser Arg Leu Arg Arg Lys Lys Asn Ser Asp Asn 
            260                 265                 270         


Ala Pro Ala Lys Gly Asn Lys Ser Pro Ser Pro Pro Asp Gly Ser Pro 
        275                 280                 285             


Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala Gly 
    290                 295                 300                 


Gly Ala Thr Pro Gly Ala Thr Leu Pro Lys Ser Pro Ser Gln Pro Ala 
305                 310                 315                 320 


Glu Ala Ser Glu Val Ala Gly Gly Thr Gln Pro Ala Ala Gly Ala Gln 
                325                 330                 335     


Glu Pro Gly Glu Thr Ala Ala Ser Glu Ala Ala Ser Ser Ser Leu Pro 
            340                 345                 350         


Ala Val Val Val Glu Thr Phe Pro Ala Thr Val Asn Gly Thr Val Glu 
        355                 360                 365             


Gly Gly Ser Gly Ala Gly Arg Leu Asp Leu Pro Pro Gly Phe Met Phe 
    370                 375                 380                 


Lys Val Gln Ala Gln His Asp Tyr Thr Ala Thr Asp Thr Asp Glu Leu 
385                 390                 395                 400 


Gln Leu Lys Ala Gly Asp Val Val Leu Val Ile Pro Phe Gln Asn Pro 
                405                 410                 415     


Glu Glu Gln Asp Glu Gly Trp Leu Met Gly Val Lys Glu Ser Asp Trp 
            420                 425                 430         


Asn Gln His Lys Glu Leu Glu Lys Cys Arg Gly Val Phe Pro Glu Asn 
        435                 440                 445             


Phe Thr Glu Arg Val Pro 
    450                 


<210>  31
<211>  1230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial cDNA sequence with exons 1 to 6; 8 to 10; 12 and 18-20
       - named short isoform 9

<400>  31
atggcagaga tgggcagtaa aggggtgacg gcgggaaaga tcgccagcaa cgtgcagaag       60

aagctcaccc gcgcgcagga gaaggttctc cagaagctgg ggaaggcaga tgagaccaag      120

gatgagcagt ttgagcagtg cgtccagaat ttcaacaagc agctgacgga gggcacccgg      180

ctgcagaagg atctccggac ctacctggcc tccgtcaaag ccatgcacga ggcttccaag      240

aagctgaatg agtgtctgca ggaggtgtat gagcccgatt ggcccggcag ggatgaggca      300

aacaagatcg cagagaacaa cgacctgctg tggatggatt accaccagaa gctggtggac      360

caggcgctgc tgaccatgga cacgtacctg ggccagttcc ccgacatcaa gtcacgcatt      420

gccaagcggg ggcgcaagct ggtggactac gacagtgccc ggcaccacta cgagtccctt      480

caaactgcca aaaagaagga tgaagccaaa attgccaagg ccgaggagga gctcatcaaa      540

gcccagaagg tgtttgagga gatgaatgtg gatctgcagg aggagctgcc gtccctgtgg      600

aacagccgcg taggtttcta cgtcaacacg ttccagagca tcgcgggcct ggaggaaaac      660

ttccacaagg agatgagcaa gctcaaccag aacctcaatg atgtgctggt cggcctggag      720

aagcaacacg ggagcaacac cttcacggtc aaggcccagc ccagtgacaa cgcgcctgca      780

aaagggaaca agagcccttc gcctccagat ggctcccctg ccgccacccc cgagatcaga      840

gtcaaccacg agccagagcc ggccggcggg gccacgcccg gggccaccct ccccaagtcc      900

ccatctcaga gctctcttcc tgctgtcgtg gtggagacct tcccagcaac tgtgaatggc      960

accgtggagg gcggcagtgg ggccgggcgc ttggacctgc ccccaggttt catgttcaag     1020

gtacaggccc agcacgacta cacggccact gacacagacg agctgcagct caaggctggt     1080

gatgtggtgc tggtgatccc cttccagaac cctgaagagc aggatgaagg ctggctcatg     1140

ggcgtgaagg agagcgactg gaaccagcac aaggagctgg agaagtgccg tggcgtcttc     1200

cccgagaact tcactgagag ggtcccatga                                      1230


<210>  32
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMINO ACID SEQUENCE corresponding to cDNA sequence with exons 1 
       to 6, 8 to 10, 12, and 18 to 20 - named short isoform 9

<400>  32

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
1               5                   10                  15      


Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
            20                  25                  30          


Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
        35                  40                  45              


Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
    50                  55                  60                  


Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                85                  90                  95      


Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
            100                 105                 110         


Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
        115                 120                 125             


Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
    130                 135                 140                 


Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
145                 150                 155                 160 


Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Ala Glu Glu 
                165                 170                 175     


Glu Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu 
            180                 185                 190         


Gln Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val 
        195                 200                 205             


Asn Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu 
    210                 215                 220                 


Met Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu 
225                 230                 235                 240 


Lys Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp 
                245                 250                 255     


Asn Ala Pro Ala Lys Gly Asn Lys Ser Pro Ser Pro Pro Asp Gly Ser 
            260                 265                 270         


Pro Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala 
        275                 280                 285             


Gly Gly Ala Thr Pro Gly Ala Thr Leu Pro Lys Ser Pro Ser Gln Ser 
    290                 295                 300                 


Ser Leu Pro Ala Val Val Val Glu Thr Phe Pro Ala Thr Val Asn Gly 
305                 310                 315                 320 


Thr Val Glu Gly Gly Ser Gly Ala Gly Arg Leu Asp Leu Pro Pro Gly 
                325                 330                 335     


Phe Met Phe Lys Val Gln Ala Gln His Asp Tyr Thr Ala Thr Asp Thr 
            340                 345                 350         


Asp Glu Leu Gln Leu Lys Ala Gly Asp Val Val Leu Val Ile Pro Phe 
        355                 360                 365             


Gln Asn Pro Glu Glu Gln Asp Glu Gly Trp Leu Met Gly Val Lys Glu 
    370                 375                 380                 


Ser Asp Trp Asn Gln His Lys Glu Leu Glu Lys Cys Arg Gly Val Phe 
385                 390                 395                 400 


Pro Glu Asn Phe Thr Glu Arg Val Pro 
                405                 


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer BIN1

<400>  33
acggcgggaa agatcgccag                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer BIN1

<400>  34
ttgtgctggt tccagtcgct                                                   20


