                         SEQUENCE LISTING

<110>  IMCHECK THERAPEUTICS
       INSERM
       CNRS
       Universit d'Aix-Marseille
       Institut Jean Paoli & Irene Calmettes
 
<120>  ANTIBODIES HAVING SPECIFICITY FOR BTN2 AND USES THEREOF

<130>  BCT200062 QT

<150>  EP19305345.1
<151>  2019-03-20

<150>  EP19219691.3
<151>  2019-12-24

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Val Leu Ala Leu Leu Leu Cys Leu Met Thr Phe Pro Ser Cys 
1               5                   10                  15      


Ala Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Val Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Thr Gly Gly Asp Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Gly Asp Thr Ala Arg Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Gly Gln Leu Gly Leu Arg Gly Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ala 
    130                 135     


<210>  2
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Thr 
        35                  40                  45              


Val Ser Ser Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln His Ser Arg Asp Leu Pro Tyr Ala Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Tyr Val Ile Ser 
1               5   


<210>  4
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Ile Trp Thr Gly Gly Asp Thr Asn Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Gly Gln Leu Gly Leu Arg Gly Tyr 
1               5                   


<210>  6
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Ala Ser Lys Thr Val Ser Ser Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  7
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln His Ser Arg Asp Leu Pro Tyr Ala 
1               5                   


<210>  9
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  9
aactatgtta taagc                                                        15


<210>  10
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  10
gtaatttgga ctggtggaga cacaaattat aattcagctc tcaaatcc                    48


<210>  11
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  11
gggggacagc tcgggctacg tggttat                                           27


<210>  12
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  12
agggccagca aaactgtcag ttcatctggc tatagttata tgcac                       45


<210>  13
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  13
cttgcatcca acctagaatc t                                                 21


<210>  14
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  14
cagcacagta gggatcttcc gtacgcg                                           27


<210>  15
<211>  408
<212>  DNA
<213>  Homo sapiens

<400>  15
atggctgtcc tggcgctact cctctgcctg atgactttcc caagctgtgc cctgtcccag       60

gtgcagctga aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcaca      120

tgcactgtct ctgggttctc attaaccaac tatgttataa gctgggttcg ccagccacca      180

ggaaagggtc tggagtggct tggagtaatt tggactggtg gagacacaaa ttataattca      240

gctctcaaat ccagactgag catcagcaaa gacaactcca agagtcaagt tttcttaaaa      300

atgaacagtc tgcaaactgg tgacacagcc aggtactact gtgccagagg gggacagctc      360

gggctacgtg gttattgggg ccaagggact ctggtcactg tctctgca                   408


<210>  16
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  16
atggagacag acacactcct gttatgggta ctgctgctct gggttccagg ttccactggt       60

gacattgtgc taacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc      120

atctcatgca gggccagcaa aactgtcagt tcatctggct atagttatat gcactggtac      180

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      240

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga tcttccgtac      360

gcgttcggag gggggaccaa gttggaaata aaa                                   393


<210>  17
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp Pro Asp Thr 
                325                 330                 335     


Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg 
            340                 345                 350         


Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn Pro Glu Arg 
        355                 360                 365             


Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe Ala Ser Gly 
    370                 375                 380                 


Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu Trp Thr Val 
385                 390                 395                 400 


Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile 
                405                 410                 415     


Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly Gln Tyr Arg 
            420                 425                 430         


Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys 
        435                 440                 445             


Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr 
    450                 455                 460                 


Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe 
465                 470                 475                 480 


Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu Asp Ser Pro 
                485                 490                 495     


Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val Thr Val Pro 
            500                 505                 510         


Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520                 525         


<210>  18
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala 
            20                  25                  30          


Gln Phe Thr Val Val Gly Pro Ala Asn Pro Ile Leu Ala Met Val Gly 
        35                  40                  45              


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
    50                  55                  60                  


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
65                  70                  75                  80  


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
                85                  90                  95      


Arg Gly Arg Ile Thr Phe Val Ser Lys Asp Ile Asn Arg Gly Ser Val 
            100                 105                 110         


Ala Leu Val Ile His Asn Val Thr Ala Gln Glu Asn Gly Ile Tyr Arg 
        115                 120                 125             


Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu Arg Leu 
    130                 135                 140                 


Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln 
145                 150                 155                 160 


Glu Asp Gly Ser Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro 
                165                 170                 175     


Glu Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala 
            180                 185                 190         


Leu Lys Glu Val Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr 
        195                 200                 205             


Thr Ala Val Ile Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser 
    210                 215                 220                 


Val Asn Asn Thr Leu Leu Gly Gln Glu Lys Glu Thr Val Ile Phe Ile 
225                 230                 235                 240 


Pro Glu Ser Phe Met Pro Ser Ala Ser Pro Trp Met Val Ala Leu Ala 
                245                 250                 255     


Val Ile Leu Thr Ala Ser Pro Trp Met Val Ser Met Thr Val Ile Leu 
            260                 265                 270         


Ala Val Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys 
        275                 280                 285             


Leu Gln Arg Glu Lys Lys Ile Leu Ser Gly Glu Lys Lys Val Glu Gln 
    290                 295                 300                 


Glu Glu Lys Glu Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg Trp Arg 
305                 310                 315                 320 


Arg Thr Phe Leu His Ala Ala Asp Val Val Leu Asp Pro Asp Thr Ala 
                325                 330                 335     


His Pro Glu Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg Gly 
            340                 345                 350         


Pro Tyr Arg Gln Arg Val Pro Asp Asn Pro Glu Arg Phe Asp Ser Gln 
        355                 360                 365             


Pro Cys Val Leu Gly Trp Glu Ser Phe Ala Ser Gly Lys His Tyr Trp 
    370                 375                 380                 


Glu Val Glu Val Glu Asn Val Met Val Trp Thr Val Gly Val Cys Arg 
385                 390                 395                 400 


His Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile Pro Gln Asn Gly 
                405                 410                 415     


Phe Trp Thr Leu Glu Met Phe Gly Asn Gln Tyr Arg Ala Leu Ser Ser 
            420                 425                 430         


Pro Glu Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys Arg Val Gly Val 
        435                 440                 445             


Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr Asn Met Arg Asp 
    450                 455                 460                 


Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe Thr Val Pro Val 
465                 470                 475                 480 


Arg Pro Phe Phe Arg Leu Gly Ser Asp Asp Ser Pro Ile Phe Ile Cys 
                485                 490                 495     


Pro Ala Leu Thr Gly Ala Ser Gly Val Met Val Pro Glu Glu Gly Leu 
            500                 505                 510         


Lys Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520             


<210>  19
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  19

Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Val Tyr Tyr Met Leu Trp Val Lys Gln Ser Pro Glu Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Pro Ser Phe Tyr Ala Leu Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135         


<210>  20
<211>  130
<212>  PRT
<213>  Mus musculus

<400>  20

Met Asp Phe Gln Met Gln Ile Ile Ser Leu Leu Leu Ile Ser Val Thr 
1               5                   10                  15      


Val Ile Val Ser His Gly Glu Ile Val Leu Thr Gln Ser Pro Thr Thr 
            20                  25                  30          


Met Ala Ala Ser Pro Gly Glu Lys Ile Thr Ile Thr Cys Ser Ala Thr 
        35                  40                  45              


Ser Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Arg His Lys Pro Gly 
    50                  55                  60                  


Phe Ser Pro Lys Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
                85                  90                  95      


Thr Ile Gly Thr Met Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Gly Ser Ser Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys 
    130 


<210>  21
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  21

Val Tyr Tyr Met Leu 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  22

Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  23
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  23

Gly Pro Ser Phe Tyr Ala Leu Asp Tyr 
1               5                   


<210>  24
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  24

Ser Ala Thr Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  25
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  25

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  26

Gln Gln Gly Ser Ser Ile Pro Arg Thr 
1               5                   


<210>  27
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  27
gtctactaca tgctc                                                        15


<210>  28
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  28
gagattaatc ctagcactgg tggtactacc tacaaccaga agttcaaggc c                51


<210>  29
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  29
ggcccgagct tttatgctct ggactac                                           27


<210>  30
<211>  36
<212>  DNA
<213>  Mus musculus

<400>  30
agtgccacct ctagtataag ttccaattac ttgcat                                 36


<210>  31
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  31
aggacatcca atctggcttc t                                                 21


<210>  32
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  32
cagcagggta gtagtatacc acgcacg                                           27


<210>  33
<211>  411
<212>  DNA
<213>  Mus musculus

<400>  33
atgggatgga actggatctt tattttaatc ctgtcagtaa ctacaggtgt ccactctgag       60

gtccagctgc agcagtctgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttactc attcactgtc tactacatgc tctgggtgaa acaaagtcct      180

gaaaagagcc ttgagtggat tggagagatt aatcctagca ctggtggtac tacctacaac      240

cagaagttca aggccaaggc cacattgact gtagacaaat cctccagcac agcctacatg      300

cagctcaaga gcctgacatc tgaggactct gcagtctatt actgtgcaag gggcccgagc      360

ttttatgctc tggactactg gggtcaagga acctcagtca ccgtctcctc a               411


<210>  34
<211>  390
<212>  DNA
<213>  Mus musculus

<400>  34
atggattttc agatgcagat tatcagcttg ctgctaatca gtgtcacagt catagtgtct       60

catggagaaa ttgtgctcac ccagtctcca accaccatgg ctgcatctcc cggggagaag      120

atcactatca cctgcagtgc cacctctagt ataagttcca attacttgca ttggtatcga      180

cataagccag gattctcccc taaactcttg atttatagga catccaatct ggcttctgga      240

gtcccaggtc gcttcagtgg cagtgggtct gggacctctt actctctcac aattggcacc      300

atggaggctg aagatgttgc cacttactac tgccagcagg gtagtagtat accacgcacg      360

ttcggagggg ggaccaagct ggaaataaaa                                       390


<210>  35
<211>  1083
<212>  PRT
<213>  Macaca fascicularis

<400>  35

Met Gln Arg Gln Phe Ser Lys Ala Ser Arg Pro Cys Leu Pro Trp Val 
1               5                   10                  15      


Leu Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu 
            20                  25                  30          


Ile Leu Leu Leu Leu Leu Leu Arg Leu Cys Ala Leu Val Ser Ala Gln 
        35                  40                  45              


Phe Thr Val Val Gly Pro Thr Asp Pro Ile Leu Ala Met Val Gly Glu 
    50                  55                  60                  


Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp 
65                  70                  75                  80  


Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val 
                85                  90                  95      


Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg 
            100                 105                 110         


Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala 
        115                 120                 125             


Leu Ile Ile His Asn Val Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys 
    130                 135                 140                 


Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Met 
145                 150                 155                 160 


Val Ala Gly Leu Gly Ser Lys Pro Leu Val Glu Met Arg Gly His Glu 
                165                 170                 175     


Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys 
            180                 185                 190         


Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Arg Val Val Pro Ala Leu 
        195                 200                 205             


Lys Glu Val Phe Pro Pro Asp Thr Asp Gly Leu Phe Met Val Thr Thr 
    210                 215                 220                 


Ala Val Ile Ile Arg Asp Lys Ser Met Arg Asn Met Ser Cys Ser Ile 
225                 230                 235                 240 


Ser Asp Thr Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro 
                245                 250                 255     


Glu Ser Phe Met Pro Ser Val Ser Pro Cys Val Val Ala Leu Pro Ile 
            260                 265                 270         


Ile Val Val Phe Leu Met Ile Ile Ile Ala Val Cys Ile Tyr Trp Ile 
        275                 280                 285             


Asn Arg Leu Gln Lys Glu Thr Lys Ile Leu Ser Gly Glu Lys Glu Ser 
    290                 295                 300                 


Glu Arg Lys Thr Arg Glu Ile Ala Val Lys Glu Leu Lys Lys Glu Arg 
305                 310                 315                 320 


Val Gln Lys Glu Lys Glu Leu Gln Val Lys Glu Gln Leu Gln Glu Glu 
                325                 330                 335     


Leu Arg Trp Arg Arg Thr Val Leu His Ala Val Asp Val Val Leu Asp 
            340                 345                 350         


Pro Asp Thr Ala His Pro Asp Leu Leu Leu Ser Glu Asp Arg Arg Ser 
        355                 360                 365             


Val Arg Arg Cys Pro Leu Gly His Leu Gly Glu Ser Val Pro Asp Asn 
    370                 375                 380                 


Pro Glu Arg Phe Asn Ser Glu Pro Cys Val Leu Gly Arg Glu Ser Phe 
385                 390                 395                 400 


Ala Ser Gly Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu 
                405                 410                 415     


Trp Thr Val Gly Val Cys Arg Asp Ser Val Glu Arg Lys Glu Glu Val 
            420                 425                 430         


Leu Leu Arg Pro Arg Asn Gly Phe Trp Thr Leu Glu Met Cys Lys Gly 
        435                 440                 445             


Gln Tyr Arg Ala Leu Ser Ser Pro Lys Arg Ile Leu Pro Leu Lys Glu 
    450                 455                 460                 


Ser Leu Cys Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val 
465                 470                 475                 480 


Ser Phe Tyr Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg 
                485                 490                 495     


Leu Ala Phe Ser Val Pro Val Arg Pro Phe Phe Arg Ile Gly Ser Asp 
            500                 505                 510         


Asp Ser Pro Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Ser Gly Ile 
        515                 520                 525             


Thr Val Pro Glu Glu Gly Leu Ile Leu His Arg Val Gly Thr Asn Gln 
    530                 535                 540                 


Ser Leu Met Pro Val Gly Thr Arg Cys Tyr Gly His Gly Met Arg Pro 
545                 550                 555                 560 


Thr Gly Phe Ile Arg Met Arg Glu Glu Arg Gly Ile His Arg Thr Thr 
                565                 570                 575     


Arg Glu Glu Arg Glu Pro Asp Met Gln Asn Phe Asp Leu Gly Ala His 
            580                 585                 590         


Trp Ser Asn Asn Leu Pro Ser Ala Arg Ser Arg Glu Phe Leu Asn Ser 
        595                 600                 605             


Asp Leu Val Pro Asp His Ser Leu Glu Ser Pro Val Thr Pro Gly Leu 
    610                 615                 620                 


Ala Asn Lys Thr Gly Glu Pro Gln Ala Glu Val Thr Cys Leu Cys Phe 
625                 630                 635                 640 


Ser Leu Pro Ser Ser Glu Leu Arg Ala Phe Pro Ser Thr Ala Thr Asn 
                645                 650                 655     


His Asn His Lys Ala Thr Ala Leu Gly Ser Asp Leu His Ile Glu Val 
            660                 665                 670         


Lys Gly Tyr Glu Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
        675                 680                 685             


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Thr Lys Gly Gln His 
    690                 695                 700                 


Ile Pro Ala Val Lys Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
705                 710                 715                 720 


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Glu Gly Val 
                725                 730                 735     


Ser Cys Ile Ile Arg Asn Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
            740                 745                 750         


Ile Ser Ile Thr Asp Pro Phe Phe Arg Asn Ala Gln Pro Trp Ile Ala 
        755                 760                 765             


Ala Leu Ala Gly Thr Leu Pro Ile Ser Leu Leu Leu Leu Ala Gly Ala 
    770                 775                 780                 


Ser Tyr Phe Leu Trp Arg Gln Gln Lys Glu Lys Ile Ala Leu Ser Arg 
785                 790                 795                 800 


Glu Thr Glu Arg Glu Arg Glu Met Lys Glu Met Gly Tyr Ala Ala Thr 
                805                 810                 815     


Lys Gln Glu Ile Ser Leu Arg Gly Gly Glu Lys Ser Leu Ala Tyr His 
            820                 825                 830         


Gly Thr His Ile Ser Tyr Leu Ala Ala Pro Glu Arg Trp Glu Met Ala 
        835                 840                 845             


Val Phe Pro Asn Ser Gly Leu Pro Arg Cys Leu Leu Thr Leu Ile Leu 
    850                 855                 860                 


Leu Gln Leu Pro Lys Leu Asp Ser Ala Pro Phe Asp Val Ile Gly Pro 
865                 870                 875                 880 


Pro Glu Pro Ile Leu Ala Val Val Gly Glu Asp Ala Glu Leu Pro Cys 
                885                 890                 895     


Arg Leu Ser Pro Asn Ala Ser Ala Glu His Leu Glu Leu Arg Trp Phe 
            900                 905                 910         


Arg Lys Lys Val Ser Pro Ala Val Leu Val His Arg Asp Gly Arg Glu 
        915                 920                 925             


Gln Glu Ala Glu Gln Met Pro Glu Tyr Arg Gly Arg Ala Thr Leu Val 
    930                 935                 940                 


Gln Asp Gly Ile Ala Glu Gly Arg Val Ala Leu Arg Ile Arg Gly Val 
945                 950                 955                 960 


Arg Val Ser Asp Asp Gly Glu Tyr Thr Cys Phe Phe Arg Glu Asp Gly 
                965                 970                 975     


Ser Tyr Glu Glu Ala Leu Val His Leu Lys Val Ala Ala Leu Gly Ser 
            980                 985                 990         


Asp Pro His Ile Ser Met Gln Val  Gln Glu Asn Gly Glu  Ile Trp Leu 
        995                 1000                 1005             


Glu Cys  Thr Ser Val Gly Trp  Tyr Pro Glu Pro Gln  Val Gln Trp 
    1010                 1015                 1020             


Arg Thr  Ser Lys Gly Glu Lys  Phe Pro Ser Thr Ser  Glu Ser Arg 
    1025                 1030                 1035             


Asn Pro  Asp Glu Glu Gly Leu  Phe Thr Val Ala Ala  Ser Val Ile 
    1040                 1045                 1050             


Ile Arg  Asp Thr Ser Val Lys  Asn Val Ser Cys Tyr  Ile Gln Asn 
    1055                 1060                 1065             


Leu Leu  Leu Gly Gln Glu Lys  Glu Val Glu Ile Phe  Ile Pro Gly 
    1070                 1075                 1080             


