                         SEQUENCE LISTING

<110>  ATRIVA Therapeutics GmbH
       GmbH, ATRIVA Therapeutics
       Ludwig, Stephan
 
<120>  RSK inhibitors in the treatment of virus diseases

<130>  OLP16685LU

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  735
<212>  PRT
<213>  human

<400>  1

Met Pro Leu Ala Gln Leu Lys Glu Pro Trp Pro Leu Met Glu Leu Val 
1               5                   10                  15      


Pro Leu Asp Pro Glu Asn Gly Gln Thr Ser Gly Glu Glu Ala Gly Leu 
            20                  25                  30          


Gln Pro Ser Lys Asp Glu Gly Val Leu Lys Glu Ile Ser Ile Thr His 
        35                  40                  45              


His Val Lys Ala Gly Ser Glu Lys Ala Asp Pro Ser His Phe Glu Leu 
    50                  55                  60                  


Leu Lys Val Leu Gly Gln Gly Ser Phe Gly Lys Val Phe Leu Val Arg 
65                  70                  75                  80  


Lys Val Thr Arg Pro Asp Ser Gly His Leu Tyr Ala Met Lys Val Leu 
                85                  90                  95      


Lys Lys Ala Thr Leu Lys Val Arg Asp Arg Val Arg Thr Lys Met Glu 
            100                 105                 110         


Arg Asp Ile Leu Ala Asp Val Asn His Pro Phe Val Val Lys Leu His 
        115                 120                 125             


Tyr Ala Phe Gln Thr Glu Gly Lys Leu Tyr Leu Ile Leu Asp Phe Leu 
    130                 135                 140                 


Arg Gly Gly Asp Leu Phe Thr Arg Leu Ser Lys Glu Val Met Phe Thr 
145                 150                 155                 160 


Glu Glu Asp Val Lys Phe Tyr Leu Ala Glu Leu Ala Leu Gly Leu Asp 
                165                 170                 175     


His Leu His Ser Leu Gly Ile Ile Tyr Arg Asp Leu Lys Pro Glu Asn 
            180                 185                 190         


Ile Leu Leu Asp Glu Glu Gly His Ile Lys Leu Thr Asp Phe Gly Leu 
        195                 200                 205             


Ser Lys Glu Ala Ile Asp His Glu Lys Lys Ala Tyr Ser Phe Cys Gly 
    210                 215                 220                 


Thr Val Glu Tyr Met Ala Pro Glu Val Val Asn Arg Gln Gly His Ser 
225                 230                 235                 240 


His Ser Ala Asp Trp Trp Ser Tyr Gly Val Leu Met Phe Glu Met Leu 
                245                 250                 255     


Thr Gly Ser Leu Pro Phe Gln Gly Lys Asp Arg Lys Glu Thr Met Thr 
            260                 265                 270         


Leu Ile Leu Lys Ala Lys Leu Gly Met Pro Gln Phe Leu Ser Thr Glu 
        275                 280                 285             


Ala Gln Ser Leu Leu Arg Ala Leu Phe Lys Arg Asn Pro Ala Asn Arg 
    290                 295                 300                 


Leu Gly Ser Gly Pro Asp Gly Ala Glu Glu Ile Lys Arg His Val Phe 
305                 310                 315                 320 


Tyr Ser Thr Ile Asp Trp Asn Lys Leu Tyr Arg Arg Glu Ile Lys Pro 
                325                 330                 335     


Pro Phe Lys Pro Ala Val Ala Gln Pro Asp Asp Thr Phe Tyr Phe Asp 
            340                 345                 350         


Thr Glu Phe Thr Ser Arg Thr Pro Lys Asp Ser Pro Gly Ile Pro Pro 
        355                 360                 365             


Ser Ala Gly Ala His Gln Leu Phe Arg Gly Phe Ser Phe Val Ala Thr 
    370                 375                 380                 


Gly Leu Met Glu Asp Asp Gly Lys Pro Arg Ala Pro Gln Ala Pro Leu 
385                 390                 395                 400 


His Ser Val Val Gln Gln Leu His Gly Lys Asn Leu Val Phe Ser Asp 
                405                 410                 415     


Gly Tyr Val Val Lys Glu Thr Ile Gly Val Gly Ser Tyr Ser Glu Cys 
            420                 425                 430         


Lys Arg Cys Val His Lys Ala Thr Asn Met Glu Tyr Ala Val Lys Val 
        435                 440                 445             


Ile Asp Lys Ser Lys Arg Asp Pro Ser Glu Glu Ile Glu Ile Leu Leu 
    450                 455                 460                 


Arg Tyr Gly Gln His Pro Asn Ile Ile Thr Leu Lys Asp Val Tyr Asp 
465                 470                 475                 480 


Asp Gly Lys His Val Tyr Leu Val Thr Glu Leu Met Arg Gly Gly Glu 
                485                 490                 495     


Leu Leu Asp Lys Ile Leu Arg Gln Lys Phe Phe Ser Glu Arg Glu Ala 
            500                 505                 510         


Ser Phe Val Leu His Thr Ile Gly Lys Thr Val Glu Tyr Leu His Ser 
        515                 520                 525             


Gln Gly Val Val His Arg Asp Leu Lys Pro Ser Asn Ile Leu Tyr Val 
    530                 535                 540                 


Asp Glu Ser Gly Asn Pro Glu Cys Leu Arg Ile Cys Asp Phe Gly Phe 
545                 550                 555                 560 


Ala Lys Gln Leu Arg Ala Glu Asn Gly Leu Leu Met Thr Pro Cys Tyr 
                565                 570                 575     


Thr Ala Asn Phe Val Ala Pro Glu Val Leu Lys Arg Gln Gly Tyr Asp 
            580                 585                 590         


Glu Gly Cys Asp Ile Trp Ser Leu Gly Ile Leu Leu Tyr Thr Met Leu 
        595                 600                 605             


Ala Gly Tyr Thr Pro Phe Ala Asn Gly Pro Ser Asp Thr Pro Glu Glu 
    610                 615                 620                 


Ile Leu Thr Arg Ile Gly Ser Gly Lys Phe Thr Leu Ser Gly Gly Asn 
625                 630                 635                 640 


Trp Asn Thr Val Ser Glu Thr Ala Lys Asp Leu Val Ser Lys Met Leu 
                645                 650                 655     


His Val Asp Pro His Gln Arg Leu Thr Ala Lys Gln Val Leu Gln His 
            660                 665                 670         


Pro Trp Val Thr Gln Lys Asp Lys Leu Pro Gln Ser Gln Leu Ser His 
        675                 680                 685             


Gln Asp Leu Gln Leu Val Lys Gly Ala Met Ala Ala Thr Tyr Ser Ala 
    690                 695                 700                 


Leu Asn Ser Ser Lys Pro Thr Pro Gln Leu Lys Pro Ile Glu Ser Ser 
705                 710                 715                 720 


Ile Leu Ala Gln Arg Arg Val Arg Lys Leu Pro Ser Thr Thr Leu 
                725                 730                 735 


<210>  2
<211>  2208
<212>  DNA
<213>  human

<400>  2
atgccgctcg cccagctcaa ggagccctgg ccgctcatgg agctagtgcc gctggacccg       60

gagaatggac agacctcagg ggaagaagct ggacttcagc cgtccaagga tgagggcgtc      120

ctcaaggaga tctccatcac gcaccacgtc aaggctggct ctgagaaggc tgatccatcc      180

catttcgagc tcctcaaggt tctgggccag ggatcctttg gcaaagtctt cctggtgcgg      240

aaagtcaccc ggcctgacag tgggcacctg tatgctatga aggtgctgaa gaaggcaacg      300

ctgaaagtac gtgaccgcgt ccggaccaag atggagagag acatcctggc tgatgtaaat      360

cacccattcg tggtgaagct gcactatgcc ttccagaccg agggcaagct ctatctcatt      420

ctggacttcc tgcgtggtgg ggacctcttc acccggctct caaaagaggt gatgttcacg      480

gaggaggatg tgaagtttta cctggccgag ctggctctgg gcctggatca cctgcacagc      540

ctgggtatca tttacagaga cctcaagcct gagaacatcc ttctggatga ggagggccac      600

atcaaactca ctgactttgg cctgagcaaa gaggccattg accacgagaa gaaggcctat      660

tctttctgcg ggacagtgga gtacatggcc cctgaggtcg tcaaccgcca gggccactcc      720

catagtgcgg actggtggtc ctatggggtg ttgatgtttg agatgctgac gggctccctg      780

cccttccagg ggaaggaccg gaaggagacc atgacactga ttctgaaggc gaagctaggc      840

atgccccagt ttctgagcac tgaagcccag agcctcttgc gggccctgtt caagcggaat      900

cctgccaacc ggctcggctc cggccctgat ggggcagagg aaatcaagcg gcatgtcttc      960

tactccacca ttgactggaa taagctatac cgtcgtgaga tcaagccacc cttcaagcca     1020

gcagtggctc agcctgatga caccttctac tttgacaccg agttcacgtc ccgcacaccc     1080

aaggattccc caggcatccc ccccagcgct ggggcccatc agctgttccg gggcttcagc     1140

ttcgtggcca ccggcctgat ggaagacgac ggcaagcctc gtgccccgca ggcacccctg     1200

cactcggtgg tacagcaact ccatgggaag aacctggttt ttagtgacgg ctacgtggta     1260

aaggagacaa ttggtgtggg ctcctactct gagtgcaagc gctgtgtcca caaggccacc     1320

aacatggagt atgctgtcaa ggtcattgat aagagcaagc gggatccttc agaagagatt     1380

gagattcttc tgcggtatgg ccagcacccc aacatcatca ctctgaaaga tgtgtatgat     1440

gatggcaaac acgtgtacct ggtgacagag ctgatgcggg gtggggagct gctggacaag     1500

atcctgcggc agaagttctt ctcagagcgg gaggccagct ttgtcctgca caccattggc     1560

aaaactgtgg agtatctgca ctcacagggg gttgtgcaca gggacctgaa gcccagcaac     1620

atcctgtatg tggacgagtc cgggaatccc gagtgcctgc gcatctgtga ctttggtttt     1680

gccaaacagc tgcgggctga gaatgggctc ctcatgacac cttgctacac agccaacttt     1740

gtggcgcctg aggtgctgaa gcgccagggc tacgatgaag gctgcgacat ctggagcctg     1800

ggcattctgc tgtacaccat gctggcagga tatactccat ttgccaacgg tcccagtgac     1860

acaccagagg aaatcctaac ccggatcggc agtgggaagt ttaccctcag tgggggaaat     1920

tggaacacag tttcagagac agccaaggac ctggtgtcca agatgctaca cgtggatccc     1980

caccagcgcc tcacagctaa gcaggttctg cagcatccat gggtcaccca gaaagacaag     2040

cttccccaaa gccagctgtc ccaccaggac ctacagcttg tgaagggagc catggctgcc     2100

acgtactccg cactcaacag ctccaagccc accccccagc tgaagcccat cgagtcatcc     2160

atcctggccc agcggcgagt gaggaagttg ccatccacca ccctgtga                  2208


<210>  3
<211>  740
<212>  PRT
<213>  human

<400>  3

Met Pro Leu Ala Gln Leu Ala Asp Pro Trp Gln Lys Met Ala Val Glu 
1               5                   10                  15      


Ser Pro Ser Asp Ser Ala Glu Asn Gly Gln Gln Ile Met Asp Glu Pro 
            20                  25                  30          


Met Gly Glu Glu Glu Ile Asn Pro Gln Thr Glu Glu Val Ser Ile Lys 
        35                  40                  45              


Glu Ile Ala Ile Thr His His Val Lys Glu Gly His Glu Lys Ala Asp 
    50                  55                  60                  


Pro Ser Gln Phe Glu Leu Leu Lys Val Leu Gly Gln Gly Ser Phe Gly 
65                  70                  75                  80  


Lys Val Phe Leu Val Lys Lys Ile Ser Gly Ser Asp Ala Arg Gln Leu 
                85                  90                  95      


Tyr Ala Met Lys Val Leu Lys Lys Ala Thr Leu Lys Val Arg Asp Arg 
            100                 105                 110         


Val Arg Thr Lys Met Glu Arg Asp Ile Leu Val Glu Val Asn His Pro 
        115                 120                 125             


Phe Ile Val Lys Leu His Tyr Ala Phe Gln Thr Glu Gly Lys Leu Tyr 
    130                 135                 140                 


Leu Ile Leu Asp Phe Leu Arg Gly Gly Asp Leu Phe Thr Arg Leu Ser 
145                 150                 155                 160 


Lys Glu Val Met Phe Thr Glu Glu Asp Val Lys Phe Tyr Leu Ala Glu 
                165                 170                 175     


Leu Ala Leu Ala Leu Asp His Leu His Ser Leu Gly Ile Ile Tyr Arg 
            180                 185                 190         


Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Glu Glu Gly His Ile Lys 
        195                 200                 205             


Leu Thr Asp Phe Gly Leu Ser Lys Glu Ser Ile Asp His Glu Lys Lys 
    210                 215                 220                 


Ala Tyr Ser Phe Cys Gly Thr Val Glu Tyr Met Ala Pro Glu Val Val 
225                 230                 235                 240 


Asn Arg Arg Gly His Thr Gln Ser Ala Asp Trp Trp Ser Phe Gly Val 
                245                 250                 255     


Leu Met Phe Glu Met Leu Thr Gly Thr Leu Pro Phe Gln Gly Lys Asp 
            260                 265                 270         


Arg Lys Glu Thr Met Thr Met Ile Leu Lys Ala Lys Leu Gly Met Pro 
        275                 280                 285             


Gln Phe Leu Ser Pro Glu Ala Gln Ser Leu Leu Arg Met Leu Phe Lys 
    290                 295                 300                 


Arg Asn Pro Ala Asn Arg Leu Gly Ala Gly Pro Asp Gly Val Glu Glu 
305                 310                 315                 320 


Ile Lys Arg His Ser Phe Phe Ser Thr Ile Asp Trp Asn Lys Leu Tyr 
                325                 330                 335     


Arg Arg Glu Ile His Pro Pro Phe Lys Pro Ala Thr Gly Arg Pro Glu 
            340                 345                 350         


Asp Thr Phe Tyr Phe Asp Pro Glu Phe Thr Ala Lys Thr Pro Lys Asp 
        355                 360                 365             


Ser Pro Gly Ile Pro Pro Ser Ala Asn Ala His Gln Leu Phe Arg Gly 
    370                 375                 380                 


Phe Ser Phe Val Ala Ile Thr Ser Asp Asp Glu Ser Gln Ala Met Gln 
385                 390                 395                 400 


Thr Val Gly Val His Ser Ile Val Gln Gln Leu His Arg Asn Ser Ile 
                405                 410                 415     


Gln Phe Thr Asp Gly Tyr Glu Val Lys Glu Asp Ile Gly Val Gly Ser 
            420                 425                 430         


Tyr Ser Val Cys Lys Arg Cys Ile His Lys Ala Thr Asn Met Glu Phe 
        435                 440                 445             


Ala Val Lys Ile Ile Asp Lys Ser Lys Arg Asp Pro Thr Glu Glu Ile 
    450                 455                 460                 


Glu Ile Leu Leu Arg Tyr Gly Gln His Pro Asn Ile Ile Thr Leu Lys 
465                 470                 475                 480 


Asp Val Tyr Asp Asp Gly Lys Tyr Val Tyr Val Val Thr Glu Leu Met 
                485                 490                 495     


Lys Gly Gly Glu Leu Leu Asp Lys Ile Leu Arg Gln Lys Phe Phe Ser 
            500                 505                 510         


Glu Arg Glu Ala Ser Ala Val Leu Phe Thr Ile Thr Lys Thr Val Glu 
        515                 520                 525             


Tyr Leu His Ala Gln Gly Val Val His Arg Asp Leu Lys Pro Ser Asn 
    530                 535                 540                 


Ile Leu Tyr Val Asp Glu Ser Gly Asn Pro Glu Ser Ile Arg Ile Cys 
545                 550                 555                 560 


Asp Phe Gly Phe Ala Lys Gln Leu Arg Ala Glu Asn Gly Leu Leu Met 
                565                 570                 575     


Thr Pro Cys Tyr Thr Ala Asn Phe Val Ala Pro Glu Val Leu Lys Arg 
            580                 585                 590         


Gln Gly Tyr Asp Ala Ala Cys Asp Ile Trp Ser Leu Gly Val Leu Leu 
        595                 600                 605             


Tyr Thr Met Leu Thr Gly Tyr Thr Pro Phe Ala Asn Gly Pro Asp Asp 
    610                 615                 620                 


Thr Pro Glu Glu Ile Leu Ala Arg Ile Gly Ser Gly Lys Phe Ser Leu 
625                 630                 635                 640 


Ser Gly Gly Tyr Trp Asn Ser Val Ser Asp Thr Ala Lys Asp Leu Val 
                645                 650                 655     


Ser Lys Met Leu His Val Asp Pro His Gln Arg Leu Thr Ala Ala Leu 
            660                 665                 670         


Val Leu Arg His Pro Trp Ile Val His Trp Asp Gln Leu Pro Gln Tyr 
        675                 680                 685             


Gln Leu Asn Arg Gln Asp Ala Pro His Leu Val Lys Gly Ala Met Ala 
    690                 695                 700                 


Ala Thr Tyr Ser Ala Leu Asn Arg Asn Gln Ser Pro Val Leu Glu Pro 
705                 710                 715                 720 


Val Gly Arg Ser Thr Leu Ala Gln Arg Arg Gly Ile Lys Lys Ile Thr 
                725                 730                 735     


Ser Thr Ala Leu 
            740 


<210>  4
<211>  2223
<212>  DNA
<213>  human

<400>  4
atgccgctgg cgcagctggc ggacccgtgg cagaagatgg ctgtggagag cccgtccgac       60

agcgctgaga atggacagca aattatggat gaacctatgg gagaggagga gattaaccca      120

caaactgaag aagtcagtat caaagaaatt gcaatcacac atcatgtaaa ggaaggacat      180

gaaaaggcag atccttccca gtttgaactt ttaaaagtat tagggcaggg atcatttgga      240

aaggttttct tagttaaaaa aatctcaggc tctgatgcta ggcagcttta tgccatgaag      300

gtattgaaga aggccacact gaaagttcga gaccgagttc ggacaaaaat ggaacgtgat      360

atcttggtag aggttaatca tccttttatt gtcaagttgc attatgcttt tcaaactgaa      420

gggaagttgt atcttatttt ggattttctc aggggaggag atttgtttac acgcttatcc      480

aaagaggtga tgttcacaga agaagatgtc aaattctact tggctgaact tgcacttgct      540

ttagaccatc tacatagcct gggaataatt tatagagact taaaaccaga aaatatactt      600

cttgatgaag aaggtcacat caagttaaca gatttcggcc taagtaaaga gtctattgac      660

catgaaaaga aggcatattc tttttgtgga actgtggagt atatggctcc agaagtagtt      720

aatcgtcgag gtcatactca gagtgctgac tggtggtctt ttggtgtgtt aatgtttgaa      780

atgcttactg gtacactccc tttccaagga aaagatcgaa aagaaacaat gactatgatt      840

cttaaagcca aacttggaat gccacagttt ttgagtcctg aagcgcagag tcttttacga      900

atgcttttca agcgaaatcc tgcaaacaga ttaggtgcag gaccagatgg agttgaagaa      960

attaaaagac attcattttt ctcaacgata gactggaata aactgtatag aagagaaatt     1020

catccgccat ttaaacctgc aacgggcagg cctgaagata cattctattt tgatcctgag     1080

tttactgcaa aaactcccaa agattcacct ggcattccac ctagtgctaa tgcacatcag     1140

ctttttcggg ggtttagttt tgttgctatt acctcagatg atgaaagcca agctatgcag     1200

acagttggtg tacattcaat tgttcagcag ttacacagga acagtattca gtttactgat     1260

ggatatgaag taaaagaaga tattggagtt ggctcctact ctgtttgcaa gagatgtata     1320

cataaagcta caaacatgga gtttgcagtg aagattattg ataaaagcaa gagagaccca     1380

acagaagaaa ttgaaattct tcttcgttat ggacagcatc caaacattat cactctaaag     1440

gatgtatatg atgatggaaa gtatgtgtat gtagtaacag aacttatgaa aggaggtgaa     1500

ttgctggata aaattcttag acaaaaattt ttctctgaac gagaggccag tgctgtcctg     1560

ttcactataa ctaaaaccgt tgaatatctt cacgcacaag gggtggttca tagagacttg     1620

aaacctagca acattcttta tgtggatgaa tctggtaatc cggaatctat tcgaatttgt     1680

gattttggct ttgcaaaaca gctgagagcg gaaaatggtc ttctcatgac tccttgttac     1740

actgcaaatt ttgttgcacc agaggtttta aaaagacaag gctatgatgc tgcttgtgat     1800

atatggagtc ttggtgtcct actctataca atgcttaccg gttacactcc atttgcaaat     1860

ggtcctgatg atacaccaga ggaaatattg gcacgaatag gtagcggaaa attctcactc     1920

agtggtggtt actggaattc tgtttcagac acagcaaagg acctggtgtc aaagatgctt     1980

catgtagacc ctcatcagag actgactgct gctcttgtgc tcagacatcc ttggatcgtc     2040

cactgggacc aactgccaca ataccaacta aacagacagg atgcaccaca tctagtaaag     2100

ggtgccatgg cagctacata ttctgctttg aaccgtaatc agtcaccagt tttggaacca     2160

gtaggccgct ctactcttgc tcagcggaga ggtattaaaa aaatcacctc aacagccctg     2220

tga                                                                   2223


<210>  5
<211>  733
<212>  PRT
<213>  human

<400>  5

Met Asp Leu Ser Met Lys Lys Phe Ala Val Arg Arg Phe Phe Ser Val 
1               5                   10                  15      


Tyr Leu Arg Arg Lys Ser Arg Ser Lys Ser Ser Ser Leu Ser Arg Leu 
            20                  25                  30          


Glu Glu Glu Gly Val Val Lys Glu Ile Asp Ile Ser His His Val Lys 
        35                  40                  45              


Glu Gly Phe Glu Lys Ala Asp Pro Ser Gln Phe Glu Leu Leu Lys Val 
    50                  55                  60                  


Leu Gly Gln Gly Ser Tyr Gly Lys Val Phe Leu Val Arg Lys Val Lys 
65                  70                  75                  80  


Gly Ser Asp Ala Gly Gln Leu Tyr Ala Met Lys Val Leu Lys Lys Ala 
                85                  90                  95      


Thr Leu Lys Val Arg Asp Arg Val Arg Ser Lys Met Glu Arg Asp Ile 
            100                 105                 110         


Leu Ala Glu Val Asn His Pro Phe Ile Val Lys Leu His Tyr Ala Phe 
        115                 120                 125             


Gln Thr Glu Gly Lys Leu Tyr Leu Ile Leu Asp Phe Leu Arg Gly Gly 
    130                 135                 140                 


Asp Leu Phe Thr Arg Leu Ser Lys Glu Val Met Phe Thr Glu Glu Asp 
145                 150                 155                 160 


Val Lys Phe Tyr Leu Ala Glu Leu Ala Leu Ala Leu Asp His Leu His 
                165                 170                 175     


Ser Leu Gly Ile Ile Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu 
            180                 185                 190         


Asp Glu Glu Gly His Ile Lys Ile Thr Asp Phe Gly Leu Ser Lys Glu 
        195                 200                 205             


Ala Ile Asp His Asp Lys Arg Ala Tyr Ser Phe Cys Gly Thr Ile Glu 
    210                 215                 220                 


Tyr Met Ala Pro Glu Val Val Asn Arg Arg Gly His Thr Gln Ser Ala 
225                 230                 235                 240 


Asp Trp Trp Ser Phe Gly Val Leu Met Phe Glu Met Leu Thr Gly Ser 
                245                 250                 255     


Leu Pro Phe Gln Gly Lys Asp Arg Lys Glu Thr Met Ala Leu Ile Leu 
            260                 265                 270         


Lys Ala Lys Leu Gly Met Pro Gln Phe Leu Ser Gly Glu Ala Gln Ser 
        275                 280                 285             


Leu Leu Arg Ala Leu Phe Lys Arg Asn Pro Cys Asn Arg Leu Gly Ala 
    290                 295                 300                 


Gly Ile Asp Gly Val Glu Glu Ile Lys Arg His Pro Phe Phe Val Thr 
305                 310                 315                 320 


Ile Asp Trp Asn Thr Leu Tyr Arg Lys Glu Ile Lys Pro Pro Phe Lys 
                325                 330                 335     


Pro Ala Val Gly Arg Pro Glu Asp Thr Phe His Phe Asp Pro Glu Phe 
            340                 345                 350         


Thr Ala Arg Thr Pro Thr Asp Ser Pro Gly Val Pro Pro Ser Ala Asn 
        355                 360                 365             


Ala His His Leu Phe Arg Gly Phe Ser Phe Val Ala Ser Ser Leu Ile 
    370                 375                 380                 


Gln Glu Pro Ser Gln Gln Asp Leu His Lys Val Pro Val His Pro Ile 
385                 390                 395                 400 


Val Gln Gln Leu His Gly Asn Asn Ile His Phe Thr Asp Gly Tyr Glu 
                405                 410                 415     


Ile Lys Glu Asp Ile Gly Val Gly Ser Tyr Ser Val Cys Lys Arg Cys 
            420                 425                 430         


Val His Lys Ala Thr Asp Thr Glu Tyr Ala Val Lys Ile Ile Asp Lys 
        435                 440                 445             


Ser Lys Arg Asp Pro Ser Glu Glu Ile Glu Ile Leu Leu Arg Tyr Gly 
    450                 455                 460                 


Gln His Pro Asn Ile Ile Thr Leu Lys Asp Val Tyr Asp Asp Gly Lys 
465                 470                 475                 480 


Phe Val Tyr Leu Val Met Glu Leu Met Arg Gly Gly Glu Leu Leu Asp 
                485                 490                 495     


Arg Ile Leu Arg Gln Arg Tyr Phe Ser Glu Arg Glu Ala Ser Asp Val 
            500                 505                 510         


Leu Cys Thr Ile Thr Lys Thr Met Asp Tyr Leu His Ser Gln Gly Val 
        515                 520                 525             


Val His Arg Asp Leu Lys Pro Ser Asn Ile Leu Tyr Arg Asp Glu Ser 
    530                 535                 540                 


Gly Ser Pro Glu Ser Ile Arg Val Cys Asp Phe Gly Phe Ala Lys Gln 
545                 550                 555                 560 


Leu Arg Ala Gly Asn Gly Leu Leu Met Thr Pro Cys Tyr Thr Ala Asn 
                565                 570                 575     


Phe Val Ala Pro Glu Val Leu Lys Arg Gln Gly Tyr Asp Ala Ala Cys 
            580                 585                 590         


Asp Ile Trp Ser Leu Gly Ile Leu Leu Tyr Thr Met Leu Ala Gly Phe 
        595                 600                 605             


Thr Pro Phe Ala Asn Gly Pro Asp Asp Thr Pro Glu Glu Ile Leu Ala 
    610                 615                 620                 


Arg Ile Gly Ser Gly Lys Tyr Ala Leu Ser Gly Gly Asn Trp Asp Ser 
625                 630                 635                 640 


Ile Ser Asp Ala Ala Lys Asp Val Val Ser Lys Met Leu His Val Asp 
                645                 650                 655     


Pro His Gln Arg Leu Thr Ala Met Gln Val Leu Lys His Pro Trp Val 
            660                 665                 670         


Val Asn Arg Glu Tyr Leu Ser Pro Asn Gln Leu Ser Arg Gln Asp Val 
        675                 680                 685             


His Leu Val Lys Gly Ala Met Ala Ala Thr Tyr Phe Ala Leu Asn Arg 
    690                 695                 700                 


Thr Pro Gln Ala Pro Arg Leu Glu Pro Val Leu Ser Ser Asn Leu Ala 
705                 710                 715                 720 


Gln Arg Arg Gly Met Lys Arg Leu Thr Ser Thr Arg Leu 
                725                 730             


<210>  6
<211>  2202
<212>  DNA
<213>  human

<400>  6
atggacctga gcatgaagaa gttcgccgtg cgcaggttct tctctgtgta cctgcgcagg       60

aagtcgcgct ccaagagctc cagcctgagc cggctcgagg aagaaggtgt cgtgaaggag      120

atagacatca gccatcatgt gaaggagggc tttgagaagg cagatccttc ccagtttgag      180

ctgctgaagg ttttaggaca aggatcctat ggaaaggtgt tcctggtgag gaaggtgaag      240

gggtccgacg ctgggcagct ctacgccatg aaggtcctta agaaagccac cctaaaagtt      300

cgggaccgag tgagatcgaa gatggagaga gacatcttgg cagaagtgaa tcaccccttc      360

attgtgaagc ttcattatgc ctttcagacg gaaggaaagc tctacctgat cctggacttc      420

ctgcggggag gggacctctt cacccggctc tccaaagagg tcatgttcac ggaggaggat      480

gtcaagttct acctggctga gctggccttg gctttagacc atctccacag cctggggatc      540

atctacagag atctgaagcc tgagaacatc ctcctggatg aagaggggca cattaagatc      600

acagatttcg gcctgagtaa ggaggccatt gaccacgaca agagagcgta ctccttctgc      660

gggacgatcg agtacatggc gcccgaggtg gtgaaccggc gaggacacac gcagagtgcc      720

gactggtggt ccttcggcgt gctcatgttt gagatgctca cggggtccct gccgttccag      780

gggaaggaca ggaaggagac catggctctc atcctcaaag ccaagctggg gatgccgcag      840

ttcctcagtg gggaggcaca gagtttgctg cgagctctct tcaaacggaa cccctgcaac      900

cggctgggtg ctggcattga cggagtggag gaaattaagc gccatccctt ctttgtgacc      960

atagactgga acacgctgta ccggaaggag atcaagccac cgttcaaacc agcagtgggc     1020

aggcctgagg acaccttcca ctttgacccc gagttcacag cgcggacgcc cacagactct     1080

cctggcgtcc ccccgagtgc aaacgctcat cacctgttta gaggattcag ctttgtggcc     1140

tcaagcctga tccaggagcc ctcacagcaa gatctgcaca aagtcccagt tcacccaatc     1200

gtgcagcagt tacacgggaa caacatccac ttcaccgatg gctacgagat caaggaggac     1260

atcggggtgg gctcctactc agtgtgcaag cgatgtgtgc ataaagccac agacaccgag     1320

tatgccgtga agatcattga taagagcaag agagacccct cggaagagat tgagatcctc     1380

ctgcggtacg gccagcaccc gaacatcatc accctcaagg atgtctatga tgatggcaag     1440

tttgtgtacc tggtaatgga gctgatgcgt ggtggggagc tcctggaccg catcctccgg     1500

cagagatact tctcggagcg cgaagccagt gacgtcctgt gcaccatcac caagaccatg     1560

gactacctcc attcccaggg ggttgttcat cgagacctga agccgagtaa catcctgtac     1620

agggatgagt cggggagccc agaatccatc cgagtctgcg acttcggctt tgccaagcag     1680

ctgcgcgcgg ggaacgggct gctcatgaca ccctgctaca cggccaattt cgtggccccg     1740

gaggtcctga agcgtcaagg ctatgatgcg gcgtgtgaca tctggagttt ggggatcctg     1800

ttgtacacca tgctggcagg atttacccct tttgcaaatg ggccagacga tacccctgag     1860

gagattctgg cgcggatcgg cagtgggaag tatgcccttt ctgggggaaa ctgggactcg     1920

atatctgacg cagctaaaga cgtcgtgtcc aagatgctcc acgtggaccc tcatcagcgc     1980

ctgacggcga tgcaagtgct caaacacccg tgggtggtca acagagagta cctgtcccca     2040

aaccagctca gccgacagga cgtgcacctg gtgaagggcg cgatggccgc cacctacttt     2100

gctctaaaca gaacacctca ggccccgcgg ctggagcccg tgctgtcgtc caacctggct     2160

cagcgcagag gcatgaagag actcacgtcc acgcggttgt ag                        2202


<210>  7
<211>  745
<212>  PRT
<213>  human

<400>  7

Met Leu Pro Phe Ala Pro Gln Asp Glu Pro Trp Asp Arg Glu Met Glu 
1               5                   10                  15      


Val Phe Ser Gly Gly Gly Ala Ser Ser Gly Glu Val Asn Gly Leu Lys 
            20                  25                  30          


Met Val Asp Glu Pro Met Glu Glu Gly Glu Ala Asp Ser Cys His Asp 
        35                  40                  45              


Glu Gly Val Val Lys Glu Ile Pro Ile Thr His His Val Lys Glu Gly 
    50                  55                  60                  


Tyr Glu Lys Ala Asp Pro Ala Gln Phe Glu Leu Leu Lys Val Leu Gly 
65                  70                  75                  80  


Gln Gly Ser Phe Gly Lys Val Phe Leu Val Arg Lys Lys Thr Gly Pro 
                85                  90                  95      


Asp Ala Gly Gln Leu Tyr Ala Met Lys Val Leu Lys Lys Ala Ser Leu 
            100                 105                 110         


Lys Val Arg Asp Arg Val Arg Thr Lys Met Glu Arg Asp Ile Leu Val 
        115                 120                 125             


Glu Val Asn His Pro Phe Ile Val Lys Leu His Tyr Ala Phe Gln Thr 
    130                 135                 140                 


Glu Gly Lys Leu Tyr Leu Ile Leu Asp Phe Leu Arg Gly Gly Asp Val 
145                 150                 155                 160 


Phe Thr Arg Leu Ser Lys Glu Val Leu Phe Thr Glu Glu Asp Val Lys 
                165                 170                 175     


Phe Tyr Leu Ala Glu Leu Ala Leu Ala Leu Asp His Leu His Gln Leu 
            180                 185                 190         


Gly Ile Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Glu 
        195                 200                 205             


Ile Gly His Ile Lys Leu Thr Asp Phe Gly Leu Ser Lys Glu Ser Val 
    210                 215                 220                 


Asp Gln Glu Lys Lys Ala Tyr Ser Phe Cys Gly Thr Val Glu Tyr Met 
225                 230                 235                 240 


Ala Pro Glu Val Val Asn Arg Arg Gly His Ser Gln Ser Ala Asp Trp 
                245                 250                 255     


Trp Ser Tyr Gly Val Leu Met Phe Glu Met Leu Thr Gly Thr Leu Pro 
            260                 265                 270         


Phe Gln Gly Lys Asp Arg Asn Glu Thr Met Asn Met Ile Leu Lys Ala 
        275                 280                 285             


Lys Leu Gly Met Pro Gln Phe Leu Ser Ala Glu Ala Gln Ser Leu Leu 
    290                 295                 300                 


Arg Met Leu Phe Lys Arg Asn Pro Ala Asn Arg Leu Gly Ser Glu Gly 
305                 310                 315                 320 


Val Glu Glu Ile Lys Arg His Leu Phe Phe Ala Asn Ile Asp Trp Asp 
                325                 330                 335     


Lys Leu Tyr Lys Arg Glu Val Gln Pro Pro Phe Lys Pro Ala Ser Gly 
            340                 345                 350         


Lys Pro Asp Asp Thr Phe Cys Phe Asp Pro Glu Phe Thr Ala Lys Thr 
        355                 360                 365             


Pro Lys Asp Ser Pro Gly Leu Pro Ala Ser Ala Asn Ala His Gln Leu 
    370                 375                 380                 


Phe Lys Gly Phe Ser Phe Val Ala Thr Ser Ile Ala Glu Glu Tyr Lys 
385                 390                 395                 400 


Ile Thr Pro Ile Thr Ser Ala Asn Val Leu Pro Ile Val Gln Ile Asn 
                405                 410                 415     


Gly Asn Ala Ala Gln Phe Gly Glu Val Tyr Glu Leu Lys Glu Asp Ile 
            420                 425                 430         


Gly Val Gly Ser Tyr Ser Val Cys Lys Arg Cys Ile His Ala Thr Thr 
        435                 440                 445             


Asn Met Glu Phe Ala Val Lys Ile Ile Asp Lys Ser Lys Arg Asp Pro 
    450                 455                 460                 


Ser Glu Glu Ile Glu Ile Leu Met Arg Tyr Gly Gln His Pro Asn Ile 
465                 470                 475                 480 


Ile Thr Leu Lys Asp Val Phe Asp Asp Gly Arg Tyr Val Tyr Leu Val 
                485                 490                 495     


Thr Asp Leu Met Lys Gly Gly Glu Leu Leu Asp Arg Ile Leu Lys Gln 
            500                 505                 510         


Lys Cys Phe Ser Glu Arg Glu Ala Ser Asp Ile Leu Tyr Val Ile Ser 
        515                 520                 525             


Lys Thr Val Asp Tyr Leu His Cys Gln Gly Val Val His Arg Asp Leu 
    530                 535                 540                 


Lys Pro Ser Asn Ile Leu Tyr Met Asp Glu Ser Ala Ser Ala Asp Ser 
545                 550                 555                 560 


Ile Arg Ile Cys Asp Phe Gly Phe Ala Lys Gln Leu Arg Gly Glu Asn 
                565                 570                 575     


Gly Leu Leu Leu Thr Pro Cys Tyr Thr Ala Asn Phe Val Ala Pro Glu 
            580                 585                 590         


Val Leu Met Gln Gln Gly Tyr Asp Ala Ala Cys Asp Ile Trp Ser Leu 
        595                 600                 605             


Gly Val Leu Phe Tyr Thr Met Leu Ala Gly Tyr Thr Pro Phe Ala Asn 
    610                 615                 620                 


Gly Pro Asn Asp Thr Pro Glu Glu Ile Leu Leu Arg Ile Gly Asn Gly 
625                 630                 635                 640 


Lys Phe Ser Leu Ser Gly Gly Asn Trp Asp Asn Ile Ser Asp Gly Ala 
                645                 650                 655     


Lys Asp Leu Leu Ser His Met Leu His Met Asp Pro His Gln Arg Tyr 
            660                 665                 670         


Thr Ala Glu Gln Ile Leu Lys His Ser Trp Ile Thr His Arg Asp Gln 
        675                 680                 685             


Leu Pro Asn Asp Gln Pro Lys Arg Asn Asp Val Ser His Val Val Lys 
    690                 695                 700                 


Gly Ala Met Val Ala Thr Tyr Ser Ala Leu Thr His Lys Thr Phe Gln 
705                 710                 715                 720 


Pro Val Leu Glu Pro Val Ala Ala Ser Ser Leu Ala Gln Arg Arg Ser 
                725                 730                 735     


Met Lys Lys Arg Thr Ser Thr Gly Leu 
            740                 745 


<210>  8
<211>  2238
<212>  DNA
<213>  human

<400>  8
atgctaccat tcgctcctca ggacgagccc tgggaccgag aaatggaagt gttcagcggc       60

ggcggcgcga gcagcggcga ggtaaatggt cttaaaatgg ttgatgagcc aatggaagag      120

ggagaagcag attcttgtca tgatgaagga gttgttaaag aaatccctat tactcatcat      180

gttaaggaag gctatgagaa agcagatcct gcacagtttg agttgctcaa ggttcttggt      240

caggggtcat ttggaaaggt ttttcttgtt agaaagaaga ccggtcctga tgctgggcag      300

ctctatgcaa tgaaggtgtt aaaaaaagcc tctttaaaag ttcgagacag agttcggaca      360

aagatggaga gggatatact ggtggaagta aatcatccat ttattgtcaa attgcactat      420

gcctttcaga ctgaagggaa actgtactta atactggatt ttctcagggg aggagatgtt      480

ttcacaagat tatccaaaga ggttctgttt acagaggaag atgtgaaatt ctacctcgca      540

gaactggccc ttgctttgga tcatctgcac caattaggaa ttgtttatag agacctgaag      600

ccagaaaaca ttttgcttga tgaaatagga catatcaaat taacagattt tggactcagc      660

aaggagtcag tagatcaaga aaagaaggct tactcatttt gtggtacagt agagtatatg      720

gctcctgaag tagtaaatag gagaggccat tcccagagtg ctgattggtg gtcatatggt      780

gttcttatgt ttgaaatgct tactggtact ctgccatttc aaggtaaaga cagaaatgag      840

accatgaata tgatattaaa agcaaaactt ggaatgcctc aatttcttag tgctgaagca      900

caaagtcttc taaggatgtt attcaaaagg aatccagcaa atagattggg atcagaagga      960

gttgaagaaa tcaaaagaca tctgtttttt gcaaatattg actgggataa attatataaa     1020

agagaagttc aacctccttt caaacctgct tctggaaaac cagatgatac tttttgtttt     1080

gatcctgaat ttactgcaaa aacacctaaa gattctcccg gtttgccagc cagtgcaaat     1140

gctcatcagc tcttcaaagg attcagcttt gttgcaactt ctattgcaga agaatataaa     1200

atcactccta tcacaagtgc aaatgtatta ccaattgttc agataaatgg aaatgctgca     1260

caatttggtg aagtatatga attgaaggag gatattggtg ttggctccta ctctgtttgc     1320

aagcgatgca tacatgcaac taccaacatg gaatttgcag tgaagatcat tgacaaaagt     1380

aagcgagacc cttcagaaga gattgaaata ttgatgcgct atggacaaca tcccaacatt     1440

attactttga aggatgtctt tgatgatggt agatatgttt accttgttac ggatttaatg     1500

aaaggaggag agttacttga ccgtattctc aaacaaaaat gtttctcgga acgggaggct     1560

agtgatatac tatatgtaat aagtaagaca gttgactatc ttcattgtca aggagttgtt     1620

catcgtgatc ttaaacctag taatatttta tacatggatg aatcagccag tgcagattca     1680

atcaggatat gtgattttgg gtttgcaaaa caacttcgag gagaaaatgg acttctctta     1740

actccatgct acactgcaaa ctttgttgca cctgaggttc ttatgcaaca gggatatgat     1800

gctgcttgtg atatctggag tttaggagtc cttttttaca caatgttggc tggctacact     1860

ccatttgcta atggccccaa tgatactcct gaagagatac tgctgcgtat aggcaatgga     1920

aaattctctt tgagtggtgg aaactgggac aatatttcag acggagcaaa ggatttgctt     1980

tcccatatgc ttcatatgga cccacatcag cggtatactg ctgaacaaat attaaagcac     2040

tcatggataa ctcacagaga ccagttgcca aatgatcagc caaagagaaa tgatgtgtca     2100

catgttgtta agggagcaat ggttgcaaca tactctgccc tgactcacaa gacctttcaa     2160

ccagtcctag agcctgtagc tgcttcaagc ttagcccagc gacggagcat gaaaaagcga     2220

acatcaactg gcctgtaa                                                   2238


