               SEQUENCE LISTING

<110> Global Bioenergies

<120> IMPROVED MEANS AND METHODS FOR PRODUCING ISOBUTENE FROM ACETYL-CoA

<130> AB2939 PCT S3

<150> EP 19 16 3981.4
<151> 2019-03-20

<150> EP 19 20 9153.6
<151> 2019-11-14

<160> 26

<170> BiSSAP 1.3.6

<210> 1
<211> 483
<212> PRT
<213> Escherichia coli


<220> 
<223> strain K12

<400> 1
Met Gln Leu Glu Val Ile Leu Pro Leu Val Ala Tyr Leu Val Val Val 
1               5                   10                  15      
Phe Gly Ile Ser Val Tyr Ala Met Arg Lys Arg Ser Thr Gly Thr Phe 
            20                  25                  30          
Leu Asn Glu Tyr Phe Leu Gly Ser Arg Ser Met Gly Gly Ile Val Leu 
        35                  40                  45              
Ala Met Thr Leu Thr Ala Thr Tyr Ile Ser Ala Ser Ser Phe Ile Gly 
    50                  55                  60                  
Gly Pro Gly Ala Ala Tyr Lys Tyr Gly Leu Gly Trp Val Leu Leu Ala 
65                  70                  75                  80  
Met Ile Gln Leu Pro Ala Val Trp Leu Ser Leu Gly Ile Leu Gly Lys 
                85                  90                  95      
Lys Phe Ala Ile Leu Ala Arg Arg Tyr Asn Ala Val Thr Leu Asn Asp 
            100                 105                 110         
Met Leu Phe Ala Arg Tyr Gln Ser Arg Leu Leu Val Trp Leu Ala Ser 
        115                 120                 125             
Leu Ser Leu Leu Val Ala Phe Val Gly Ala Met Thr Val Gln Phe Ile 
    130                 135                 140                 
Gly Gly Ala Arg Leu Leu Glu Thr Ala Ala Gly Ile Pro Tyr Glu Thr 
145                 150                 155                 160 
Gly Leu Leu Ile Phe Gly Ile Ser Ile Ala Leu Tyr Thr Ala Phe Gly 
                165                 170                 175     
Gly Phe Arg Ala Ser Val Leu Asn Asp Thr Met Gln Gly Leu Val Met 
            180                 185                 190         
Leu Ile Gly Thr Val Val Leu Leu Ile Gly Val Val His Ala Ala Gly 
        195                 200                 205             
Gly Leu Ser Asn Ala Val Gln Thr Leu Gln Thr Ile Asp Pro Gln Leu 
    210                 215                 220                 
Val Thr Pro Gln Gly Ala Asp Asp Ile Leu Ser Pro Ala Phe Met Thr 
225                 230                 235                 240 
Ser Phe Trp Val Leu Val Cys Phe Gly Val Ile Gly Leu Pro His Thr 
                245                 250                 255     
Ala Val Arg Cys Ile Ser Tyr Lys Asp Ser Lys Ala Val His Arg Gly 
            260                 265                 270         
Ile Ile Ile Gly Thr Ile Val Val Ala Ile Leu Met Phe Gly Met His 
        275                 280                 285             
Leu Ala Gly Ala Leu Gly Arg Ala Val Ile Pro Asp Leu Thr Val Pro 
    290                 295                 300                 
Asp Leu Val Ile Pro Thr Leu Met Val Lys Val Leu Pro Pro Phe Ala 
305                 310                 315                 320 
Ala Gly Ile Phe Leu Ala Ala Pro Met Ala Ala Ile Met Ser Thr Ile 
                325                 330                 335     
Asn Ala Gln Leu Leu Gln Ser Ser Ala Thr Ile Ile Lys Asp Leu Tyr 
            340                 345                 350         
Leu Asn Ile Arg Pro Asp Gln Met Gln Asn Glu Thr Arg Leu Lys Arg 
        355                 360                 365             
Met Ser Ala Val Ile Thr Leu Val Leu Gly Ala Leu Leu Leu Leu Ala 
    370                 375                 380                 
Ala Trp Lys Pro Pro Glu Met Ile Ile Trp Leu Asn Leu Leu Ala Phe 
385                 390                 395                 400 
Gly Gly Leu Glu Ala Val Phe Leu Trp Pro Leu Val Leu Gly Leu Tyr 
                405                 410                 415     
Trp Glu Arg Ala Asn Ala Lys Gly Ala Leu Ser Ala Met Ile Val Gly 
            420                 425                 430         
Gly Val Leu Tyr Ala Val Leu Ala Thr Leu Asn Ile Gln Tyr Leu Gly 
        435                 440                 445             
Phe His Pro Ile Val Pro Ser Leu Leu Leu Ser Leu Leu Ala Phe Leu 
    450                 455                 460                 
Val Gly Asn Arg Phe Gly Thr Ser Val Pro Gln Ala Thr Val Leu Thr 
465                 470                 475                 480 
Thr Asp Lys 
            

<210> 2
<211> 512
<212> PRT
<213> Saccharomyces cerevisiae


<220> 
<223> strain ATCC 204508 / S288c

<400> 2
Met Met Lys Glu Ser Lys Ser Ile Thr Gln His Glu Val Glu Arg Glu 
1               5                   10                  15      
Ser Val Ser Ser Lys Arg Ala Ile Lys Lys Arg Leu Leu Leu Phe Lys 
            20                  25                  30          
Ile Asp Leu Phe Val Leu Ser Phe Val Cys Leu Gln Tyr Trp Ile Asn 
        35                  40                  45              
Tyr Val Asp Arg Val Gly Phe Thr Asn Ala Tyr Ile Ser Gly Met Lys 
    50                  55                  60                  
Glu Asp Leu Lys Met Val Gly Asn Asp Leu Thr Val Ser Asn Thr Val 
65                  70                  75                  80  
Phe Met Ile Gly Tyr Ile Val Gly Met Val Pro Asn Asn Leu Met Leu 
                85                  90                  95      
Leu Cys Val Pro Pro Arg Ile Trp Leu Ser Phe Cys Thr Phe Ala Trp 
            100                 105                 110         
Gly Leu Leu Thr Leu Gly Met Tyr Lys Val Thr Ser Phe Lys His Ile 
        115                 120                 125             
Cys Ala Ile Arg Phe Phe Gln Ala Leu Phe Glu Ser Cys Thr Phe Ser 
    130                 135                 140                 
Gly Thr His Phe Val Leu Gly Ser Trp Tyr Lys Glu Asp Glu Leu Pro 
145                 150                 155                 160 
Ile Arg Ser Ala Ile Phe Thr Gly Ser Gly Leu Val Gly Ser Met Phe 
                165                 170                 175     
Ser Gly Phe Met Gln Thr Ser Ile Phe Thr His Leu Asn Gly Arg Asn 
            180                 185                 190         
Gly Leu Ala Gly Trp Arg Trp Leu Phe Ile Ile Asp Phe Cys Ile Thr 
        195                 200                 205             
Leu Pro Ile Ala Ile Tyr Gly Phe Ile Phe Phe Pro Gly Leu Pro Asp 
    210                 215                 220                 
Gln Thr Ser Ala Val Ser Lys Phe Ser Met Thr Arg Tyr Ile Phe Asn 
225                 230                 235                 240 
Glu Gln Glu Leu His Tyr Ala Arg Arg Arg Leu Pro Ala Arg Asp Glu 
                245                 250                 255     
Ser Thr Arg Leu Asp Trp Ser Thr Ile Pro Arg Val Leu Lys Arg Trp 
            260                 265                 270         
His Trp Trp Met Phe Ser Leu Val Trp Val Leu Gly Gly Glu Asn Leu 
        275                 280                 285             
Gly Phe Ala Ser Asn Ser Thr Phe Ala Leu Trp Leu Gln Asn Gln Lys 
    290                 295                 300                 
Tyr Thr Leu Ala Gln Arg Asn Asn Tyr Pro Ser Gly Ile Phe Ala Val 
305                 310                 315                 320 
Gly Ile Val Ser Thr Leu Cys Ser Ala Val Tyr Met Ser Lys Ile Pro 
                325                 330                 335     
Arg Ala Arg His Trp His Val Ser Val Phe Ile Ser Leu Val Met Val 
            340                 345                 350         
Ile Val Ala Val Leu Ile Arg Ala Asp Pro Leu Asn Pro Lys Val Val 
        355                 360                 365             
Phe Ser Ala Gln Tyr Leu Gly Gly Val Ala Tyr Ala Gly Gln Ala Val 
    370                 375                 380                 
Phe Phe Ser Trp Ala Asn Ile Ile Cys His Ala Asp Leu Gln Glu Arg 
385                 390                 395                 400 
Ala Ile Val Leu Ala Ser Met Asn Met Phe Ser Gly Ala Val Asn Ala 
                405                 410                 415     
Trp Trp Ser Ile Leu Phe Phe Ala Ser Asp Met Val Pro Lys Phe Glu 
            420                 425                 430         
Arg Gly Cys Tyr Ala Leu Leu Ala Thr Ala Ile Ser Ser Gly Ile Val 
        435                 440                 445             
Ser Val Val Ile Arg Ser Leu Gln Ile Lys Glu Asn Leu Ser Lys Lys 
    450                 455                 460                 
Gln Val Pro Tyr Ile Asp Ala Asn Asp Met Pro Gly Glu Asp Asp Asp 
465                 470                 475                 480 
Asp Asp Asn Gln Asp Asn Glu Asn Asp Gly Asp Asp Glu Ser Met Glu 
                485                 490                 495     
Val Glu Leu His Asn Glu Glu Met Ala Glu Ile Ser Asn Pro Phe Arg 
            500                 505                 510         



<210> 3
<211> 514
<212> PRT
<213> Schizosaccharomyces pombe


<220> 
<223> strain 972 / ATCC 24843

<400> 3
Met Ala Leu Leu Asn Arg Leu Ala Lys Thr Phe Ser Pro Tyr Tyr Gly 
1               5                   10                  15      
Leu Asn Lys Val Glu Gln Lys Leu Leu Ile Lys Ile Asp Trp Phe Ile 
            20                  25                  30          
Leu Ser Tyr Cys Cys Val Ser Tyr Phe Ile Asn Tyr Leu Asp Arg Ser 
        35                  40                  45              
Ser Ile Asn Asn Ala Tyr Leu Ser Gly Met Gln Glu Asp Leu Lys Met 
    50                  55                  60                  
His Gly Asn Glu Leu Gln Asp Ile Asn Val Val Phe Thr Cys Gly Tyr 
65                  70                  75                  80  
Ile Ile Gly Gln Leu Pro Gly Ser Tyr Ala Leu Gln Arg Val Pro Ala 
                85                  90                  95      
Arg Leu Trp Phe Ser Val Met Asn Ile Leu Trp Gly Leu Met Thr Ile 
            100                 105                 110         
Phe Ser Phe Ala Val His Ser Val Arg Ala Leu Met Ile Leu Arg Phe 
        115                 120                 125             
Phe Met Ala Val Ala Glu Ala Ser Thr Phe Ala Gly Thr His Tyr Ile 
    130                 135                 140                 
Leu Gly Ala Trp Tyr Lys Glu Ser Glu Leu Cys Lys Arg Ala Gly Ile 
145                 150                 155                 160 
Phe Ser Ala Ser Gly Leu Val Gly Thr Met Phe Ala Gly Tyr Leu Gln 
                165                 170                 175     
Thr Ala Val His Ser Ser Leu Asn Gly Lys Gly Gly Leu Ser Gly Trp 
            180                 185                 190         
Arg Trp Leu Phe Ile Ile Asp Gly Ile Leu Thr Ile Pro Leu Ser Leu 
        195                 200                 205             
Tyr Gly Leu Phe Leu Phe Pro Asp Val Pro Glu Thr Thr Lys Ala Pro 
    210                 215                 220                 
Tyr Phe Thr Glu Gln Glu Lys Glu Leu Ser Phe Lys Arg Leu Pro Ala 
225                 230                 235                 240 
Arg Pro Lys Lys Lys Pro Leu Thr Leu Lys Ala Ile Lys Asp Ile Val 
                245                 250                 255     
Arg Ser Trp Arg Ile Tyr Gly Leu Cys Ile Leu Trp Ile Phe Ser Gly 
            260                 265                 270         
Glu Thr Gln Ala Ile Ala Val Asn Val Leu Met Gly Gln Trp Met Lys 
        275                 280                 285             
Trp Ser Asn Lys Phe Ser Val Ala Gln Ile Asn Asn Tyr Pro Thr Val 
    290                 295                 300                 
Ile Thr Ala Val Gly Val Val Ser Thr Leu Gly Ala Ser Val Ile Ser 
305                 310                 315                 320 
Asp Lys Leu Ala Gly Asn Pro Arg Trp Pro Phe Gly Leu Phe Leu Cys 
                325                 330                 335     
Val Ile Thr Thr Val Ser Ala Thr Ile Leu Leu Ala Trp Asn Val Pro 
            340                 345                 350         
Asp Gly Ala Lys Phe Phe Ala Tyr Phe Ala Ser Gly Cys Thr Tyr Ala 
        355                 360                 365             
Gly Gln Ala Val Trp Phe Ser Trp Ala Asn Asp Ile Cys Arg Asp Asn 
    370                 375                 380                 
Asp Gln Glu Arg Gly Val Val Val Phe Leu Met Asn Met Cys Gln Asn 
385                 390                 395                 400 
Ile Trp His Ile Trp Trp Ala Pro Ile Met Tyr Pro Asn Thr Asp Thr 
                405                 410                 415     
Pro Arg Phe Ile Lys Gly Leu Ile Gly Leu Leu Val Val Gly Gly Ile 
            420                 425                 430         
Val Phe Val Ser Ser Cys Ile Val Ser Tyr Met Gln Ile Arg Asp Lys 
        435                 440                 445             
Arg Ile Lys Arg Ser Ile Gln Asp Ala Lys Asp Phe Asp Asp Val Phe 
    450                 455                 460                 
Thr Glu His Glu Ser Leu Glu Leu Lys Lys Ile Gly Lys Asn Asp Glu 
465                 470                 475                 480 
Glu Ser Leu Asn Thr Thr Asn Ala Val Lys Glu Ile Ser Ser Pro Gly 
                485                 490                 495     
Leu Val Ile Thr Arg Gln Arg Ile Ser Met Pro Lys Glu Thr Asn Ala 
            500                 505                 510         
Gln Asp 
        

<210> 4
<211> 196
<212> PRT
<213> Lactococcus lactis subsp. cremoris


<220> 
<223> strain MG1363

<400> 4
Met Lys Lys Ser Lys Ala Ser Asp Val Ala Ile Leu Ala Ile Phe Ile 
1               5                   10                  15      
Ala Ile Met Val Val Val Gln Leu Phe Thr Gln Phe Val Ile Asn Val 
            20                  25                  30          
Trp Pro Phe Pro Val Lys Pro Thr Leu Leu His Leu Pro Val Ile Ile 
        35                  40                  45              
Gly Ser Ile Ile Leu Gly Trp Arg Lys Gly Ala Phe Leu Gly Leu Val 
    50                  55                  60                  
Trp Gly Leu Ile Ser Phe Val Thr Ala Thr Ile Val Thr Thr Pro Thr 
65                  70                  75                  80  
Ser Phe Leu Phe Ser Pro Phe Gln Pro Val Ile Gly Thr His His Gly 
                85                  90                  95      
Ser Pro Trp Gly Leu Phe Ile Ala Phe Ile Pro Arg Ile Leu Val Gly 
            100                 105                 110         
Ile Leu Pro Tyr Phe Val Tyr Lys Ile Ala Asn Asn Arg Leu Gly Ala 
        115                 120                 125             
Gly Leu Ala Ala Phe Ala Gly Thr Ala Thr Asn Thr Val Leu Val Leu 
    130                 135                 140                 
Thr Ser Ile Phe Leu Phe Phe Gly Ser Thr Leu Lys Trp Ser Leu Ser 
145                 150                 155                 160 
Tyr Leu Leu Gly Ala Ile Val Ala Thr Asn Ser Leu Thr Glu Val Ile 
                165                 170                 175     
Ile Ala Val Ile Leu Thr Thr Ala Ile Val Pro Ala Leu Thr Lys Ala 
            180                 185                 190         
Arg Asn Asn Ser 
        195     

<210> 5
<211> 316
<212> PRT
<213> Escherichia coli


<220> 
<223> strain K12

<400> 5
Met Ser Ile Lys Glu Gln Thr Leu Met Thr Pro Tyr Leu Gln Phe Asp 
1               5                   10                  15      
Arg Asn Gln Trp Ala Ala Leu Arg Asp Ser Val Pro Met Thr Leu Ser 
            20                  25                  30          
Glu Asp Glu Ile Ala Arg Leu Lys Gly Ile Asn Glu Asp Leu Ser Leu 
        35                  40                  45              
Glu Glu Val Ala Glu Ile Tyr Leu Pro Leu Ser Arg Leu Leu Asn Phe 
    50                  55                  60                  
Tyr Ile Ser Ser Asn Leu Arg Arg Gln Ala Val Leu Glu Gln Phe Leu 
65                  70                  75                  80  
Gly Thr Asn Gly Gln Arg Ile Pro Tyr Ile Ile Ser Ile Ala Gly Ser 
                85                  90                  95      
Val Ala Val Gly Lys Ser Thr Thr Ala Arg Val Leu Gln Ala Leu Leu 
            100                 105                 110         
Ser Arg Trp Pro Glu His Arg Arg Val Glu Leu Ile Thr Thr Asp Gly 
        115                 120                 125             
Phe Leu His Pro Asn Gln Val Leu Lys Glu Arg Gly Leu Met Lys Lys 
    130                 135                 140                 
Lys Gly Phe Pro Glu Ser Tyr Asp Met His Arg Leu Val Lys Phe Val 
145                 150                 155                 160 
Ser Asp Leu Lys Ser Gly Val Pro Asn Val Thr Ala Pro Val Tyr Ser 
                165                 170                 175     
His Leu Ile Tyr Asp Val Ile Pro Asp Gly Asp Lys Thr Val Val Gln 
            180                 185                 190         
Pro Asp Ile Leu Ile Leu Glu Gly Leu Asn Val Leu Gln Ser Gly Met 
        195                 200                 205             
Asp Tyr Pro His Asp Pro His His Val Phe Val Ser Asp Phe Val Asp 
    210                 215                 220                 
Phe Ser Ile Tyr Val Asp Ala Pro Glu Asp Leu Leu Gln Thr Trp Tyr 
225                 230                 235                 240 
Ile Asn Arg Phe Leu Lys Phe Arg Glu Gly Ala Phe Thr Asp Pro Asp 
                245                 250                 255     
Ser Tyr Phe His Asn Tyr Ala Lys Leu Thr Lys Glu Glu Ala Ile Lys 
            260                 265                 270         
Thr Ala Met Thr Leu Trp Lys Glu Ile Asn Trp Leu Asn Leu Lys Gln 
        275                 280                 285             
Asn Ile Leu Pro Thr Arg Glu Arg Ala Ser Leu Ile Leu Thr Lys Ser 
    290                 295                 300                 
Ala Asn His Ala Val Glu Glu Val Arg Leu Arg Lys 
305                 310                 315     

<210> 6
<211> 316
<212> PRT
<213> Escherichia coli


<220> 
<223> strain K12 variant R106A

<400> 6
Met Ser Ile Lys Glu Gln Thr Leu Met Thr Pro Tyr Leu Gln Phe Asp 
1               5                   10                  15      
Arg Asn Gln Trp Ala Ala Leu Arg Asp Ser Val Pro Met Thr Leu Ser 
            20                  25                  30          
Glu Asp Glu Ile Ala Arg Leu Lys Gly Ile Asn Glu Asp Leu Ser Leu 
        35                  40                  45              
Glu Glu Val Ala Glu Ile Tyr Leu Pro Leu Ser Arg Leu Leu Asn Phe 
    50                  55                  60                  
Tyr Ile Ser Ser Asn Leu Arg Arg Gln Ala Val Leu Glu Gln Phe Leu 
65                  70                  75                  80  
Gly Thr Asn Gly Gln Arg Ile Pro Tyr Ile Ile Ser Ile Ala Gly Ser 
                85                  90                  95      
Val Ala Val Gly Lys Ser Thr Thr Ala Ala Val Leu Gln Ala Leu Leu 
            100                 105                 110         
Ser Arg Trp Pro Glu His Arg Arg Val Glu Leu Ile Thr Thr Asp Gly 
        115                 120                 125             
Phe Leu His Pro Asn Gln Val Leu Lys Glu Arg Gly Leu Met Lys Lys 
    130                 135                 140                 
Lys Gly Phe Pro Glu Ser Tyr Asp Met His Arg Leu Val Lys Phe Val 
145                 150                 155                 160 
Ser Asp Leu Lys Ser Gly Val Pro Asn Val Thr Ala Pro Val Tyr Ser 
                165                 170                 175     
His Leu Ile Tyr Asp Val Ile Pro Asp Gly Asp Lys Thr Val Val Gln 
            180                 185                 190         
Pro Asp Ile Leu Ile Leu Glu Gly Leu Asn Val Leu Gln Ser Gly Met 
        195                 200                 205             
Asp Tyr Pro His Asp Pro His His Val Phe Val Ser Asp Phe Val Asp 
    210                 215                 220                 
Phe Ser Ile Tyr Val Asp Ala Pro Glu Asp Leu Leu Gln Thr Trp Tyr 
225                 230                 235                 240 
Ile Asn Arg Phe Leu Lys Phe Arg Glu Gly Ala Phe Thr Asp Pro Asp 
                245                 250                 255     
Ser Tyr Phe His Asn Tyr Ala Lys Leu Thr Lys Glu Glu Ala Ile Lys 
            260                 265                 270         
Thr Ala Met Thr Leu Trp Lys Glu Ile Asn Trp Leu Asn Leu Lys Gln 
        275                 280                 285             
Asn Ile Leu Pro Thr Arg Glu Arg Ala Ser Leu Ile Leu Thr Lys Ser 
    290                 295                 300                 
Ala Asn His Ala Val Glu Glu Val Arg Leu Arg Lys 
305                 310                 315     

<210> 7
<211> 267
<212> PRT
<213> Staphylococcus aureus


<220> 
<223> strain MSSA476

<400> 7
Met Lys Val Gly Ile Asp Ala Gly Gly Thr Leu Ile Lys Ile Val Gln 
1               5                   10                  15      
Glu Gln Asp Asn Gln Arg Thr Phe Lys Thr Glu Leu Thr Lys Asn Ile 
            20                  25                  30          
Asp Gln Val Val Glu Trp Leu Asn Gln Gln Gln Ile Glu Lys Leu Cys 
        35                  40                  45              
Leu Thr Gly Gly Asn Ala Gly Val Ile Ala Glu Asn Ile Asn Ile Pro 
    50                  55                  60                  
Ala Gln Ile Phe Val Glu Phe Asp Ala Ala Ser Gln Gly Leu Gly Ile 
65                  70                  75                  80  
Leu Leu Lys Glu Gln Gly His Asp Leu Ala Asp Tyr Ile Phe Ala Asn 
                85                  90                  95      
Val Gly Thr Gly Thr Ser Leu His Tyr Phe Asp Gly Gln Ser Gln Arg 
            100                 105                 110         
Arg Val Gly Gly Ile Gly Thr Gly Gly Gly Met Ile Gln Gly Leu Gly 
        115                 120                 125             
Tyr Leu Leu Ser Gln Ile Thr Asp Tyr Lys Gln Leu Thr Asp Met Ala 
    130                 135                 140                 
Gln His Gly Asp Arg Asn Thr Ile Asp Leu Lys Val Arg His Ile Tyr 
145                 150                 155                 160 
Lys Asp Thr Glu Pro Pro Ile Pro Gly Asp Leu Thr Ala Ala Asn Phe 
                165                 170                 175     
Gly His Val Leu His His Leu Asp Ala Asp Phe Thr Pro Ser Asn Lys 
            180                 185                 190         
Leu Ala Ala Val Ile Gly Val Val Gly Glu Val Val Thr Thr Met Ala 
        195                 200                 205             
Ile Thr Val Ala Arg Glu Phe Lys Thr Glu Asn Ile Val Tyr Ile Gly 
    210                 215                 220                 
Ser Ser Phe His Asn Asn Ala Leu Leu Arg Lys Val Val Glu Asp Tyr 
225                 230                 235                 240 
Thr Val Leu Arg Gly Cys Lys Pro Tyr Tyr Val Glu Asn Gly Ala Phe 
                245                 250                 255     
Ser Gly Ala Ile Gly Ala Leu Tyr Leu Glu Lys 
            260                 265         

<210> 8
<211> 223
<212> PRT
<213> Helicobacter pylori


<220> 
<223> strain ATCC 700392 / 26695

<400> 8
Met Pro Ala Arg Gln Ser Phe Thr Asp Leu Lys Asn Leu Val Leu Cys 
1               5                   10                  15      
Asp Ile Gly Asn Thr Arg Ile His Phe Ala Gln Asn Tyr Gln Leu Phe 
            20                  25                  30          
Ser Ser Ala Lys Glu Asp Leu Lys Arg Leu Gly Ile Gln Lys Glu Ile 
        35                  40                  45              
Phe Tyr Ile Ser Val Asn Glu Glu Asn Glu Lys Ala Leu Leu Asn Cys 
    50                  55                  60                  
Tyr Pro Asn Ala Lys Asn Ile Ala Gly Phe Phe His Leu Glu Thr Asp 
65                  70                  75                  80  
Tyr Val Gly Leu Gly Ile Asp Arg Gln Met Ala Cys Leu Ala Val Asn 
                85                  90                  95      
Asn Gly Val Val Val Asp Ala Gly Ser Ala Ile Thr Ile Asp Leu Ile 
            100                 105                 110         
Lys Glu Gly Lys His Leu Gly Gly Cys Ile Leu Pro Gly Leu Ala Gln 
        115                 120                 125             
Tyr Ile His Ala Tyr Lys Lys Ser Ala Lys Ile Leu Glu Gln Pro Phe 
    130                 135                 140                 
Lys Ala Leu Asp Ser Leu Glu Val Leu Pro Lys Ser Thr Arg Asp Ala 
145                 150                 155                 160 
Val Asn Tyr Gly Met Val Leu Ser Val Ile Ala Cys Ile Gln His Leu 
                165                 170                 175     
Ala Lys Asn Gln Lys Ile Tyr Leu Cys Gly Gly Asp Ala Lys Tyr Leu 
            180                 185                 190         
Ser Ala Phe Leu Pro His Ser Val Cys Lys Glu Arg Leu Val Phe Asp 
        195                 200                 205             
Gly Met Glu Ile Ala Leu Lys Lys Ala Gly Ile Leu Glu Cys Lys 
    210                 215                 220             

<210> 9
<211> 258
<212> PRT
<213> Bacillus subtilis


<400> 9
Met Leu Leu Val Ile Asp Val Gly Asn Thr Asn Thr Val Leu Gly Val 
1               5                   10                  15      
Tyr His Asp Gly Lys Leu Glu Tyr His Trp Arg Ile Glu Thr Ser Arg 
            20                  25                  30          
His Lys Thr Glu Asp Glu Phe Gly Met Ile Leu Arg Ser Leu Phe Asp 
        35                  40                  45              
His Ser Gly Leu Met Phe Glu Gln Ile Asp Gly Ile Ile Ile Ser Ser 
    50                  55                  60                  
Val Val Pro Pro Ile Met Phe Ala Leu Glu Arg Met Cys Thr Lys Tyr 
65                  70                  75                  80  
Phe His Ile Glu Pro Gln Ile Val Gly Pro Gly Met Lys Thr Gly Leu 
                85                  90                  95      
Asn Ile Lys Tyr Asp Asn Pro Lys Glu Val Gly Ala Asp Arg Ile Val 
            100                 105                 110         
Asn Ala Val Ala Ala Ile His Leu Tyr Gly Asn Pro Leu Ile Val Val 
        115                 120                 125             
Asp Phe Gly Thr Ala Thr Thr Tyr Cys Tyr Ile Asp Glu Asn Lys Gln 
    130                 135                 140                 
Tyr Met Gly Gly Ala Ile Ala Pro Gly Ile Thr Ile Ser Thr Glu Ala 
145                 150                 155                 160 
Leu Tyr Ser Arg Ala Ala Lys Leu Pro Arg Ile Glu Ile Thr Arg Pro 
                165                 170                 175     
Asp Asn Ile Ile Gly Lys Asn Thr Val Ser Ala Met Gln Ser Gly Ile 
            180                 185                 190         
Leu Phe Gly Tyr Val Gly Gln Val Glu Gly Ile Val Lys Arg Met Lys 
        195                 200                 205             
Trp Gln Ala Lys Gln Lys Gln Lys Val Ile Ala Thr Gly Gly Leu Ala 
    210                 215                 220                 
Pro Leu Ile Ala Asn Glu Ser Asp Cys Ile Asp Ile Val Asp Pro Phe 
225                 230                 235                 240 
Leu Thr Leu Lys Gly Leu Glu Leu Ile Tyr Glu Arg Asn Arg Val Gly 
                245                 250                 255     
Ser Val 
        

<210> 10
<211> 257
<212> PRT
<213> Enterococcus faecalis


<400> 10
Met Asp Val Leu Val Thr Ala Gly Gly Thr Ser Glu Pro Ile Asp Asn 
1               5                   10                  15      
Val Arg Ser Ile Thr Asn His Ser Ser Gly Gly Leu Gly Lys Ala Ile 
            20                  25                  30          
Ala Glu Ser Phe Leu Ala Ala Gly His Thr Val Thr Tyr Val Thr Thr 
        35                  40                  45              
Lys His Ala Leu Arg Pro Thr Gln Gln Leu Asp Leu Ser Ile Lys Glu 
    50                  55                  60                  
Ile Glu Thr Thr Val Glu Leu Ala Thr Thr Leu Glu Gln Leu Phe Ala 
65                  70                  75                  80  
Glu Lys Gln Phe Asp Ala Ile Val His Ala Met Ala Val Ser Asp Phe 
                85                  90                  95      
Thr Thr Glu Thr Ala Gln Thr Glu Glu Gln Phe Ile Asp Ser Phe Ala 
            100                 105                 110         
Gln Gln Leu Ser Glu Gln Thr Leu Pro Lys Thr Lys Glu Ala Leu Val 
        115                 120                 125             
Thr Ile Val Gln Asn Thr Leu Asn Gln Ile Ala Asp Ile Pro Gln Thr 
    130                 135                 140                 
Ala Thr Lys Ile Ser Ser Asp Thr Asp Arg Leu Leu Ile Phe Leu Lys 
145                 150                 155                 160 
Lys Asn Pro Lys Val Ile Gln Met Ile Arg Asp Lys Gln Pro Gln Thr 
                165                 170                 175     
Val Leu Val Gly Phe Lys Leu Leu Val Asn Val Ser Gln Glu Glu Leu 
            180                 185                 190         
Val Gln Val Ala Gln Ala Ala Leu Val Lys Asn Arg Cys Asp Phe Val 
        195                 200                 205             
Leu Ala Asn Asp Leu Met Asn Val His Glu Thr Glu His Lys Gly Leu 
    210                 215                 220                 
Leu Ile Asn Glu Thr Gly Ile Val Gln Glu Ala Tyr Ser Lys Gln Gly 
225                 230                 235                 240 
Ile Gly Ser Met Ile Val Lys Asn Val Glu Lys Lys Trp Arg Glu Gln 
                245                 250                 255     
Gln 
    

<210> 11
<211> 365
<212> PRT
<213> Saccharomyces cerevisiae


<220> 
<223> strain ATCC 204508 / S288c

<400> 11
Met Pro Pro Leu Pro Val Leu Asn Arg Pro Gln Ile His Thr Ser Val 
1               5                   10                  15      
Thr Glu Ile Ser His Ala Ile Asp Arg Thr Ile Lys Glu Glu Leu Phe 
            20                  25                  30          
Pro Val Ala Tyr Thr Thr Glu Glu Glu Gln Tyr Phe Lys Thr Asn Pro 
        35                  40                  45              
Lys Pro Ala Tyr Ile Asp Glu Leu Ile Lys Asp Ala Lys Glu Phe Ile 
    50                  55                  60                  
Asp Leu Gln Tyr Ser Leu Lys Arg Asn Lys Ile Val Leu Ile Thr Ser 
65                  70                  75                  80  
Gly Gly Thr Thr Val Pro Leu Glu Asn Asn Thr Val Arg Phe Ile Asp 
                85                  90                  95      
Asn Phe Ser Ala Gly Thr Arg Gly Ala Ser Ser Ala Glu Gln Phe Leu 
            100                 105                 110         
Ala Asn Gly Tyr Ser Val Ile Phe Leu His Arg Glu Phe Ser Leu Thr 
        115                 120                 125             
Pro Tyr Asn Arg Ser Phe Ser His Ser Ile Asn Thr Leu Phe Leu Asp 
    130                 135                 140                 
Tyr Ile Asp Ser Glu Gly Lys Ile Lys Pro Glu Phe Ala Glu Asn Val 
145                 150                 155                 160 
Leu Lys Asn Lys Lys Leu Tyr Asp Lys Tyr Met Glu Lys Glu Glu Lys 
                165                 170                 175     
Leu Leu Leu Leu Pro Phe Thr Thr Val Asn Gln Tyr Leu Trp Ser Leu 
            180                 185                 190         
Lys Ser Ile Ala Lys Leu Leu Asn Asn Ser Gly Cys Leu Phe Tyr Leu 
        195                 200                 205             
Ala Ala Ala Val Ser Asp Phe Phe Val Pro Tyr Ser Arg Leu Pro Gln 
    210                 215                 220                 
His Lys Ile Gln Ser Gly Asp Asn Gly Lys Met Gly Ala Asn Asn Asp 
225                 230                 235                 240 
Thr Glu Gly Thr Thr Arg Thr Thr Pro Asp Gly Lys Leu Ile Val Asn 
                245                 250                 255     
Leu Asp Pro Val Pro Lys Phe Leu Arg Arg Leu Val Glu Ser Trp Ala 
            260                 265                 270         
Thr Gln Ala Met Ile Val Ser Phe Lys Leu Glu Thr Asp Glu Ser Met 
        275                 280                 285             
Leu Leu Tyr Lys Cys Thr Gln Ala Leu Asp Arg Tyr Asn His Gln Leu 
    290                 295                 300                 
Val Ile Gly Asn Leu Leu Gln Thr Arg Asn Lys Gln Val Ile Phe Val 
305                 310                 315                 320 
Ser Pro Glu Asn Arg Lys Gly Asp Trp Val Arg Leu Asp Glu Lys His 
                325                 330                 335     
His Ser Ile Glu Glu Met Ile Ile Pro Glu Val Ile Ala Arg His Asp 
            340                 345                 350         
Lys Trp Val Ala His Ser Lys Thr Lys Leu Ala Thr Lys 
        355                 360                 365 

<210> 12
<211> 406
<212> PRT
<213> Escherichia coli


<220> 
<223> strain K12

<400> 12
Met Ser Leu Ala Gly Lys Lys Ile Val Leu Gly Val Ser Gly Gly Ile 
1               5                   10                  15      
Ala Ala Tyr Lys Thr Pro Glu Leu Val Arg Arg Leu Arg Asp Arg Gly 
            20                  25                  30          
Ala Asp Val Arg Val Ala Met Thr Glu Ala Ala Lys Ala Phe Ile Thr 
        35                  40                  45              
Pro Leu Ser Leu Gln Ala Val Ser Gly Tyr Pro Val Ser Asp Ser Leu 
    50                  55                  60                  
Leu Asp Pro Ala Ala Glu Ala Ala Met Gly His Ile Glu Leu Gly Lys 
65                  70                  75                  80  
Trp Ala Asp Leu Val Ile Leu Ala Pro Ala Thr Ala Asp Leu Ile Ala 
                85                  90                  95      
Arg Val Ala Ala Gly Met Ala Asn Asp Leu Val Ser Thr Ile Cys Leu 
            100                 105                 110         
Ala Thr Pro Ala Pro Val Ala Val Leu Pro Ala Met Asn Gln Gln Met 
        115                 120                 125             
Tyr Arg Ala Ala Ala Thr Gln His Asn Leu Glu Val Leu Ala Ser Arg 
    130                 135                 140                 
Gly Leu Leu Ile Trp Gly Pro Asp Ser Gly Ser Gln Ala Cys Gly Asp 
145                 150                 155                 160 
Ile Gly Pro Gly Arg Met Leu Asp Pro Leu Thr Ile Val Asp Met Ala 
                165                 170                 175     
Val Ala His Phe Ser Pro Val Asn Asp Leu Lys His Leu Asn Ile Met 
            180                 185                 190         
Ile Thr Ala Gly Pro Thr Arg Glu Pro Leu Asp Pro Val Arg Tyr Ile 
        195                 200                 205             
Ser Asn His Ser Ser Gly Lys Met Gly Phe Ala Ile Ala Ala Ala Ala 
    210                 215                 220                 
Ala Arg Arg Gly Ala Asn Val Thr Leu Val Ser Gly Pro Val Ser Leu 
225                 230                 235                 240 
Pro Thr Pro Pro Phe Val Lys Arg Val Asp Val Met Thr Ala Leu Glu 
                245                 250                 255     
Met Glu Ala Ala Val Asn Ala Ser Val Gln Gln Gln Asn Ile Phe Ile 
            260                 265                 270         
Gly Cys Ala Ala Val Ala Asp Tyr Arg Ala Ala Thr Val Ala Pro Glu 
        275                 280                 285             
Lys Ile Lys Lys Gln Ala Thr Gln Gly Asp Glu Leu Thr Ile Lys Met 
    290                 295                 300                 
Val Lys Asn Pro Asp Ile Val Ala Gly Val Ala Ala Leu Lys Asp His 
305                 310                 315                 320 
Arg Pro Tyr Val Val Gly Phe Ala Ala Glu Thr Asn Asn Val Glu Glu 
                325                 330                 335     
Tyr Ala Arg Gln Lys Arg Ile Arg Lys Asn Leu Asp Leu Ile Cys Ala 
            340                 345                 350         
Asn Asp Val Ser Gln Pro Thr Gln Gly Phe Asn Ser Asp Asn Asn Ala 
        355                 360                 365             
Leu His Leu Phe Trp Gln Asp Gly Asp Lys Val Leu Pro Leu Glu Arg 
    370                 375                 380                 
Lys Glu Leu Leu Gly Gln Leu Leu Leu Asp Glu Ile Val Thr Arg Tyr 
385                 390                 395                 400 
Asp Glu Lys Asn Arg Arg 
                405     

<210> 13
<211> 401
<212> PRT
<213> Streptococcus pneumoniae


<400> 13
Met Leu Lys Gly Lys Lys Ile Leu Leu Cys Val Thr Gly Gly Ile Ala 
1               5                   10                  15      
Val Phe Lys Ala Ala Ala Leu Thr Ser Lys Leu Thr Gln Ala Gly Ala 
            20                  25                  30          
Ile Val Lys Val Met Met Ser Glu Ser Ala Val Lys Phe Val Thr Pro 
        35                  40                  45              
Leu Thr Phe Gln Ala Leu Ser Arg His Asp Val Tyr Thr Asp Thr Phe 
    50                  55                  60                  
Asp Glu Lys Asp Ser Ala Val Ile Ala His Ile Asp Leu Ala Asp Trp 
65                  70                  75                  80  
Ala Asp Val Val Leu Val Ala Pro Ala Thr Ala Asn Cys Ile Gly Lys 
                85                  90                  95      
Leu Ala Asn Gly Ile Ala Asp Asp Met Ile Thr Thr Thr Leu Leu Ala 
            100                 105                 110         
Thr Thr Ala Pro Val Trp Ile Ala Pro Ala Met Asn Val His Met Tyr 
        115                 120                 125             
Glu Asn Lys Ile Val Gln Lys Asn Met Met Thr Leu Lys Thr Leu Gly 
    130                 135                 140                 
Tyr Thr Phe Ile Glu Pro Gly Glu Gly Phe Leu Ala Cys Gly Tyr Val 
145                 150                 155                 160 
Ala Lys Gly Arg Leu Glu Glu Pro Glu Ala Ile Ile Ala Arg Leu Glu 
                165                 170                 175     
Glu Ala Phe Ser Glu Gln Lys Pro Leu Gln Gly Lys Arg Ile Leu Ile 
            180                 185                 190         
Thr Ala Gly Pro Thr Arg Glu Lys Ile Asp Pro Val Arg Phe Met Thr 
        195                 200                 205             
Asn Phe Ser Ser Gly Lys Met Gly Tyr Ala Ile Ala Glu Val Ala Ala 
    210                 215                 220                 
Asn Leu Gly Ala Glu Val Ile Leu Val Ser Gly Pro Thr Ala Leu Asn 
225                 230                 235                 240 
Pro Pro Leu His Val Thr Thr Val Gln Val Glu Ser Ala Gln Asp Met 
                245                 250                 255     
Leu Glu Ala Val Ile Gln His Tyr Gln Asn Val Asp Val Val Ile Lys 
            260                 265                 270         
Thr Ala Ala Val Ala Asp Tyr Arg Pro Lys Tyr Val His Asp Asn Lys 
        275                 280                 285             
Met Lys Lys Lys Asn Gly Asp Ala Val Ile Glu Leu Glu Arg Thr Val 
    290                 295                 300                 
Asp Ile Leu Lys Thr Leu Gly Glu Met Lys Asp Lys Gln Leu Leu Ile 
305                 310                 315                 320 
Gly Phe Ala Ala Glu Thr Thr Asn Val Glu Glu Tyr Ala Thr Lys Lys 
                325                 330                 335     
Leu Arg Glu Lys Asn Ala Asn Met Ile Val Ala Asn Asp Val Lys Ala 
            340                 345                 350         
Gln Gly Ala Gly Phe Gly Thr Asp Thr Asn Ile Val Thr Met Tyr Arg 
        355                 360                 365             
Lys Asp Gly Glu Val Ile Glu Leu Pro Leu Leu Thr Lys Lys Glu Val 
    370                 375                 380                 
Ala Arg Glu Ile Leu Lys Gln Ile Glu Met Met Leu Glu Asp Asp Arg 
385                 390                 395                 400 
Leu 
    

<210> 14
<211> 184
<212> PRT
<213> Enterococcus faecalis


<400> 14
Met Lys Thr Ile Leu Leu Gly Val Ser Gly Ser Ile Ser Ala Tyr Lys 
1               5                   10                  15      
Ala Ala Asp Ile Thr Ser Gln Leu Ala Lys Leu Gly Tyr Asn Val Glu 
            20                  25                  30          
Ile Leu Met Thr Lys Ser Ser Thr Ala Phe Ile Thr Pro Leu Thr Leu 
        35                  40                  45              
Gln Ser Leu Ser Lys Asn Pro Val His Thr Asp Val Met Met Glu Ile 
    50                  55                  60                  
Asp Pro Ser Lys Ile Asn His Ile Glu Leu Ala Lys Lys Ala Asp Leu 
65                  70                  75                  80  
Phe Leu Val Ala Pro Ala Ser Ala Asn Thr Ile Gly Lys Leu Ala His 
                85                  90                  95      
Gly Ile Ala Asp Asp Leu Leu Ser Thr Val Ala Leu Ala Leu Tyr Pro 
            100                 105                 110         
Glu Thr Pro Lys Ile Ile Ala Pro Ala Met Asn Thr Tyr Met Tyr Gln 
        115                 120                 125             
Asn Pro Ile Val Gln Arg Asn Ile Gly Ile Leu Lys Glu Val Gly Tyr 
    130                 135                 140                 
Gln Glu Ile Ile Pro Arg Glu Ala Leu Leu Ala Cys Gly Asp Tyr Gly 
145                 150                 155                 160 
Arg Gly Ala Leu Ala Thr Val Glu Asp Ile Leu Gln Thr Val Met Lys 
                165                 170                 175     
Ile Leu Ala Ser Asp Asn Lys Glu 
            180                 

<210> 15
<211> 562
<212> PRT
<213> Saccharomyces cerevisiae


<220> 
<223> strain ATCC 204508 / S288c

<400> 15
Met Thr Ala Val Ala Ser Thr Ser Gly Lys Gln Asp Ala Asp His Asn 
1               5                   10                  15      
Gln Ser Ile Glu Cys Pro Arg Phe Ser Arg Gly Gln Lys Glu Ile Leu 
            20                  25                  30          
Leu Asp His Glu Asp Ala Lys Gly Lys Asp Ser Ile Ile Asn Ser Pro 
        35                  40                  45              
Val Ser Gly Arg Gln Ser Ile Ser Pro Thr Leu Ser Asn Ala Thr Thr 
    50                  55                  60                  
Thr Thr Thr Lys Ser Ile Met Asn Ala Thr Gly Thr Ser Gly Ala Val 
65                  70                  75                  80  
Val Ser Asn Thr Pro Glu Pro Gly Leu Lys Arg Val Pro Ala Val Thr 
                85                  90                  95      
Phe Ser Asp Leu Lys Gln Gln Gln Lys Gln Asp Ser Leu Thr Gln Leu 
            100                 105                 110         
Lys Asn Asp Ser Glu Arg Thr Lys Ser Pro Asn Ser Asn Pro Ala Pro 
        115                 120                 125             
Val Ser Asn Ser Ile Pro Gly Asn His Ala Val Ile Pro Asn His Thr 
    130                 135                 140                 
Asn Thr Ser Arg Thr Thr Gln Leu Ser Gly Ser Pro Leu Val Asn Glu 
145                 150                 155                 160 
Met Lys Asp Tyr Asp Pro Lys Lys Lys Asp Ser Ala Leu Lys Ile Val 
                165                 170                 175     
Asp Thr Met Lys Pro Asp Lys Ile Met Ala Thr Ser Thr Pro Ile Ser 
            180                 185                 190         
Arg Glu Asn Asn Lys Val Thr Ala Lys Ala Pro Thr Ser Ile Thr Leu 
        195                 200                 205             
Arg Lys Glu Asp Ala Gln Asp Gln Ala Asn Asn Val Ser Gly Gln Ile 
    210                 215                 220                 
Asn Val Arg Ser Thr Pro Glu Glu Thr Pro Val Lys Gln Ser Val Ile 
225                 230                 235                 240 
Pro Ser Ile Ile Pro Lys Arg Glu Asn Ser Lys Asn Leu Asp Pro Arg 
                245                 250                 255     
Leu Pro Gln Asp Asp Gly Lys Leu His Val Leu Phe Gly Ala Thr Gly 
            260                 265                 270         
Ser Leu Ser Val Phe Lys Ile Lys Pro Met Ile Lys Lys Leu Glu Glu 
        275                 280                 285             
Ile Tyr Gly Arg Asp Arg Ile Ser Ile Gln Val Ile Leu Thr Gln Ser 
    290                 295                 300                 
Ala Thr Gln Phe Phe Glu Gln Arg Tyr Thr Lys Lys Ile Ile Lys Ser 
305                 310                 315                 320 
Ser Glu Lys Leu Asn Lys Met Ser Gln Tyr Glu Ser Thr Pro Ala Thr 
                325                 330                 335     
Pro Val Thr Pro Thr Pro Gly Gln Cys Asn Met Ala Gln Val Val Glu 
            340                 345                 350         
Leu Pro Pro His Ile Gln Leu Trp Thr Asp Gln Asp Glu Trp Asp Ala 
        355                 360                 365             
Trp Lys Gln Arg Thr Asp Pro Val Leu His Ile Glu Leu Arg Arg Trp 
    370                 375                 380                 
Ala Asp Ile Leu Val Val Ala Pro Leu Thr Ala Asn Thr Leu Ser Lys 
385                 390                 395                 400 
Ile Ala Leu Gly Leu Cys Asp Asn Leu Leu Thr Ser Val Ile Arg Ala 
                405                 410                 415     
Trp Asn Pro Ser Tyr Pro Ile Leu Leu Ala Pro Ser Met Val Ser Ser 
            420                 425                 430         
Thr Phe Asn Ser Met Met Thr Lys Lys Gln Leu Gln Thr Ile Lys Glu 
        435                 440                 445             
Glu Met Ser Trp Val Thr Val Phe Lys Pro Ser Glu Lys Val Met Asp 
    450                 455                 460                 
Ile Asn Gly Asp Ile Gly Leu Gly Gly Met Met Asp Trp Asn Glu Ile 
465                 470                 475                 480 
Val Asn Lys Ile Val Met Lys Leu Gly Gly Tyr Pro Lys Asn Asn Glu 
                485                 490                 495     
Glu Glu Asp Asp Asp Glu Asp Glu Glu Glu Asp Asp Asp Glu Glu Glu 
            500                 505                 510         
Asp Thr Glu Asp Lys Asn Glu Asn Asn Asn Asp Asp Asp Asp Asp Asp 
        515                 520                 525             
Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
    530                 535                 540                 
Asp Asp Glu Asp Glu Asp Glu Ala Glu Thr Pro Gly Ile Ile Asp Lys 
545                 550                 555                 560 
His Gln 
        

<210> 16
<211> 160
<212> PRT
<213> Staphylococcus aureus


<220> 
<223> strain MW2

<400> 16
Met Glu His Thr Ile Ala Val Ile Pro Gly Ser Phe Asp Pro Ile Thr 
1               5                   10                  15      
Tyr Gly His Leu Asp Ile Ile Glu Arg Ser Thr Asp Arg Phe Asp Glu 
            20                  25                  30          
Ile His Val Cys Val Leu Lys Asn Ser Lys Lys Glu Gly Thr Phe Ser 
        35                  40                  45              
Leu Glu Glu Arg Met Asp Leu Ile Glu Gln Ser Val Lys His Leu Pro 
    50                  55                  60                  
Asn Val Lys Val His Gln Phe Ser Gly Leu Leu Val Asp Tyr Cys Glu 
65                  70                  75                  80  
Gln Val Gly Ala Lys Thr Ile Ile Arg Gly Leu Arg Ala Val Ser Asp 
                85                  90                  95      
Phe Glu Tyr Glu Leu Arg Leu Thr Ser Met Asn Lys Lys Leu Asn Asn 
            100                 105                 110         
Glu Ile Glu Thr Leu Tyr Met Met Ser Ser Thr Asn Tyr Ser Phe Ile 
        115                 120                 125             
Ser Ser Ser Ile Val Lys Glu Val Ala Ala Tyr Arg Ala Asp Ile Ser 
    130                 135                 140                 
Glu Phe Val Pro Pro Tyr Val Glu Lys Ala Leu Lys Lys Lys Phe Lys 
145                 150                 155                 160 



<210> 17
<211> 166
<212> PRT
<213> Burkholderia pseudomallei


<220> 
<223> strain 1710b

<400> 17
Met Val Val Ala Val Tyr Pro Gly Thr Phe Asp Pro Leu Thr Arg Gly 
1               5                   10                  15      
His Glu Asp Leu Val Arg Arg Ala Ser Ser Ile Phe Asp Thr Leu Val 
            20                  25                  30          
Val Gly Val Ala Asp Ser Arg Ala Lys Lys Pro Phe Phe Ser Leu Glu 
        35                  40                  45              
Glu Arg Leu Lys Ile Ala Asn Glu Val Leu Gly His Tyr Pro Asn Val 
    50                  55                  60                  
Lys Val Met Gly Phe Thr Gly Leu Leu Lys Asp Phe Val Arg Ala Asn 
65                  70                  75                  80  
Asp Ala Arg Val Ile Val Arg Gly Leu Arg Ala Val Ser Asp Phe Glu 
                85                  90                  95      
Tyr Glu Phe Gln Met Ala Gly Met Asn Arg Tyr Leu Leu Pro Asp Val 
            100                 105                 110         
Glu Thr Met Phe Met Thr Pro Ser Asp Gln Tyr Gln Phe Ile Ser Gly 
        115                 120                 125             
Thr Ile Val Arg Glu Ile Ala Gln Leu Gly Gly Asp Val Ser Lys Phe 
    130                 135                 140                 
Val Phe Pro Ser Val Glu Lys Trp Leu Thr Glu Lys Val Ala Ala Met 
145                 150                 155                 160 
Ala Gln Gly Pro Ser Ala 
                165     

<210> 18
<211> 159
<212> PRT
<213> Escherichia coli


<220> 
<223> strain K12

<400> 18
Met Gln Lys Arg Ala Ile Tyr Pro Gly Thr Phe Asp Pro Ile Thr Asn 
1               5                   10                  15      
Gly His Ile Asp Ile Val Thr Arg Ala Thr Gln Met Phe Asp His Val 
            20                  25                  30          
Ile Leu Ala Ile Ala Ala Ser Pro Ser Lys Lys Pro Met Phe Thr Leu 
        35                  40                  45              
Glu Glu Arg Val Ala Leu Ala Gln Gln Ala Thr Ala His Leu Gly Asn 
    50                  55                  60                  
Val Glu Val Val Gly Phe Ser Asp Leu Met Ala Asn Phe Ala Arg Asn 
65                  70                  75                  80  
Gln His Ala Thr Val Leu Ile Arg Gly Leu Arg Ala Val Ala Asp Phe 
                85                  90                  95      
Glu Tyr Glu Met Gln Leu Ala His Met Asn Arg His Leu Met Pro Glu 
            100                 105                 110         
Leu Glu Ser Val Phe Leu Met Pro Ser Lys Glu Trp Ser Phe Ile Ser 
        115                 120                 125             
Ser Ser Leu Val Lys Glu Val Ala Arg His Gln Gly Asp Val Thr His 
    130                 135                 140                 
Phe Leu Pro Glu Asn Val His Gln Ala Leu Met Ala Lys Leu Ala 
145                 150                 155                 

<210> 19
<211> 206
<212> PRT
<213> Escherichia coli


<220> 
<223> strain K12

<400> 19
Met Arg Tyr Ile Val Ala Leu Thr Gly Gly Ile Gly Ser Gly Lys Ser 
1               5                   10                  15      
Thr Val Ala Asn Ala Phe Ala Asp Leu Gly Ile Asn Val Ile Asp Ala 
            20                  25                  30          
Asp Ile Ile Ala Arg Gln Val Val Glu Pro Gly Ala Pro Ala Leu His 
        35                  40                  45              
Ala Ile Ala Asp His Phe Gly Ala Asn Met Ile Ala Ala Asp Gly Thr 
    50                  55                  60                  
Leu Gln Arg Arg Ala Leu Arg Glu Arg Ile Phe Ala Asn Pro Glu Glu 
65                  70                  75                  80  
Lys Asn Trp Leu Asn Ala Leu Leu His Pro Leu Ile Gln Gln Glu Thr 
                85                  90                  95      
Gln His Gln Ile Gln Gln Ala Thr Ser Pro Tyr Val Leu Trp Val Val 
            100                 105                 110         
Pro Leu Leu Val Glu Asn Ser Leu Tyr Lys Lys Ala Asn Arg Val Leu 
        115                 120                 125             
Val Val Asp Val Ser Pro Glu Thr Gln Leu Lys Arg Thr Met Gln Arg 
    130                 135                 140                 
Asp Asp Val Thr Arg Glu His Val Glu Gln Ile Leu Ala Ala Gln Ala 
145                 150                 155                 160 
Thr Arg Glu Ala Arg Leu Ala Val Ala Asp Asp Val Ile Asp Asn Asn 
                165                 170                 175     
Gly Ala Pro Asp Ala Ile Ala Ser Asp Val Ala Arg Leu His Ala His 
            180                 185                 190         
Tyr Leu Gln Leu Ala Ser Gln Phe Val Ser Gln Glu Lys Pro 
        195                 200                 205     

<210> 20
<211> 241
<212> PRT
<213> Saccharomyces cerevisiae


<220> 
<223> strain ATCC 204508 / S288c

<400> 20
Met Leu Val Val Gly Leu Thr Gly Gly Ile Ala Cys Gly Lys Ser Thr 
1               5                   10                  15      
Val Ser Arg Arg Leu Arg Asp Lys Tyr Lys Leu Pro Ile Val Asp Ala 
            20                  25                  30          
Asp Lys Ile Ala Arg Gln Val Val Glu Pro Gly Gln Asn Ala Tyr Asp 
        35                  40                  45              
Gln Ile Val Leu Tyr Phe Lys Asp Lys Ile Pro Asn Leu Leu Leu Glu 
    50                  55                  60                  
Asp Gly His Leu Asn Arg Glu Ala Leu Gly Lys Trp Val Phe Ser His 
65                  70                  75                  80  
Lys Glu Asp Leu Gln Ala Leu Asn Gly Ile Thr His Pro Ala Ile Arg 
                85                  90                  95      
Tyr Ala Met Phe Lys Glu Ile Gly Tyr Tyr Tyr Leu Lys Gly Tyr Arg 
            100                 105                 110         
Met Cys Val Leu Asp Val Pro Leu Leu Phe Glu Gly Asn Leu Asp Ser 
        115                 120                 125             
Ile Cys Gly Val Thr Val Ser Val Ile Cys Thr Gln Glu Leu Gln Leu 
    130                 135                 140                 
Glu Arg Leu Met Thr Arg Asn Pro Glu Leu Ser Glu Glu Asp Ala Lys 
145                 150                 155                 160 
Asn Arg Leu Asn Ser Gln Met Ser Thr Glu Glu Arg Met Ala Arg Ser 
                165                 170                 175     
Asp Tyr Ile Leu Gln Asn Asn Ser Thr Leu Val Asp Leu Tyr Glu Gln 
            180                 185                 190         
Ile Glu Ser Val Val Lys Lys Ile Gln Pro Ser Lys Leu Arg Thr Val 
        195                 200                 205             
Leu Glu Tyr Phe Pro Pro Phe Gly Ala Val Ser Ala Ser Ser Ile Val 
    210                 215                 220                 
Met Ser Arg Leu Leu Met Lys Lys Leu Gln Asn Lys Lys Ser Ser Ala 
225                 230                 235                 240 
Val 
    

<210> 21
<211> 501
<212> PRT
<213> Streptomyces sp.


<400> 21
Met Tyr Val Gln Met Val Phe Val Lys Glu Val Pro Val Gln His Pro 
1               5                   10                  15      
Ser Asp Leu Arg Glu His Ile Glu Ala Leu Glu Lys Leu Gly Asp Leu 
            20                  25                  30          
Asp Arg Val His Asp Glu Val Asp Trp Asn Leu Glu Ala Ala Ala Gln 
        35                  40                  45              
Thr Arg Tyr Ser Thr Glu His His Leu Pro Ala Pro Leu Phe Glu Asn 
    50                  55                  60                  
Val Ala Gly Val Ala Glu Gly Phe Arg Leu Leu Gly Ala Pro Ala Ala 
65                  70                  75                  80  
Leu Ser Ser Asp Pro Ser Arg Pro Tyr Ala Arg Val Ala Leu Ser Val 
                85                  90                  95      
Gly Leu Arg Pro Glu Ala Thr Gly Arg Glu Val Val Glu His Leu Val 
            100                 105                 110         
Ala Ala Arg His Arg Pro Gly Val Pro Pro Val Ala Val Ala Ala Glu 
        115                 120                 125             
Ala Ala Pro Val Lys Ala Asn Val Leu Leu Gly Asp Glu Ala Asp Leu 
    130                 135                 140                 
Asn Arg Phe Pro Val Pro Phe Val His Glu Gly Asp Gly Asn Arg Tyr 
145                 150                 155                 160 
Ala Asn Thr Tyr Gly Val Ile Ile Ala Gln Thr Pro Asp Gly Ser Trp 
                165                 170                 175     
Thr Asn Trp Ser Ile Ala Arg Ile Met Met Ile Asp Gly Lys His Met 
            180                 185                 190         
Thr Gly Leu Val Met His Pro Gln His Ile Ala Gln Val Trp Gln Gln 
        195                 200                 205             
Trp Ala Asp Leu Gly Lys Pro Met Pro Tyr Ala Leu Val Gln Gly Gly 
    210                 215                 220                 
Asp Pro Ala Ile Pro Tyr Val Gly Gly Ile Pro Ile Gly Asp Gly Val 
225                 230                 235                 240 
Ala Glu Ser Ala Tyr Ile Gly Ala Leu Ile Gly Arg Pro Leu Glu Val 
                245                 250                 255     
Val Lys Ala Glu Leu Ser Asp Leu Met Val Pro Ala Gly Ala Glu Ile 
            260                 265                 270         
Val Ile Glu Gly His Leu Ser Val Gln Arg Asp Gly Val Glu Gly Pro 
        275                 280                 285             
Phe Gly Glu Phe Ala Gly Tyr Ile Pro Arg Glu Thr Ser Leu Gln Pro 
    290                 295                 300                 
Val Tyr Thr Val Glu Ala Ile Thr His Arg Asp Ala Pro Ile Trp Pro 
305                 310                 315                 320 
Leu Val Ala Glu Gly Lys Pro Thr Asp Asp Phe His Thr Val Thr Gly 
                325                 330                 335     
Ile Gly Glu Ala Ala Gly Ala Leu Asp Ala Ile Arg Glu Ala Gly Leu 
            340                 345                 350         
Pro Ala Ala Ser Ala Trp Ala Pro Leu Ser Ala Ala Ser His Trp Leu 
        355                 360                 365             
Val Val Thr Ala Pro Gly Asn Trp Arg Glu Leu Leu Pro Gly Val Ser 
    370                 375                 380                 
Glu Glu Gln Tyr Ala Arg Arg Val Gly Glu Ala Val Phe Gly Thr Lys 
385                 390                 395                 400 
Phe Gly Ser Cys Leu Pro Gln Val Phe Leu Leu Asp Asp Asp Phe Asp 
                405                 410                 415     
Pro Thr Asp Asp Ala Asp Leu Leu Trp Ala Leu Ala Thr Arg Val His 
            420                 425                 430         
Pro Asp Gly Arg Val Val Arg Phe Glu Asp Gly Pro Val Leu Pro Leu 
        435                 440                 445             
Leu Thr Cys Tyr Thr Pro Gln Glu Arg His Ala Ala Arg Ala Thr Lys 
    450                 455                 460                 
Val Val His Glu Ala Leu Leu Ser Ala Pro Gly Glu Arg Glu Pro Gln 
465                 470                 475                 480 
Ser Thr Phe Ala Asp Ala Tyr Pro Ala Glu Val Arg Ala Lys Val Arg 
                485                 490                 495     
Ala Arg Tyr Pro Asn 
            500     

<210> 22
<211> 652
<212> PRT
<213> Escherichia coli


<220> 
<223> strain K12

<400> 22
Met Ser Gln Ile His Lys His Thr Ile Pro Ala Asn Ile Ala Asp Arg 
1               5                   10                  15      
Cys Leu Ile Asn Pro Gln Gln Tyr Glu Ala Met Tyr Gln Gln Ser Ile 
            20                  25                  30          
Asn Val Pro Asp Thr Phe Trp Gly Glu Gln Gly Lys Ile Leu Asp Trp 
        35                  40                  45              
Ile Lys Pro Tyr Gln Lys Val Lys Asn Thr Ser Phe Ala Pro Gly Asn 
    50                  55                  60                  
Val Ser Ile Lys Trp Tyr Glu Asp Gly Thr Leu Asn Leu Ala Ala Asn 
65                  70                  75                  80  
Cys Leu Asp Arg His Leu Gln Glu Asn Gly Asp Arg Thr Ala Ile Ile 
                85                  90                  95      
Trp Glu Gly Asp Asp Ala Ser Gln Ser Lys His Ile Ser Tyr Lys Glu 
            100                 105                 110         
Leu His Arg Asp Val Cys Arg Phe Ala Asn Thr Leu Leu Glu Leu Gly 
        115                 120                 125             
Ile Lys Lys Gly Asp Val Val Ala Ile Tyr Met Pro Met Val Pro Glu 
    130                 135                 140                 
Ala Ala Val Ala Met Leu Ala Cys Ala Arg Ile Gly Ala Val His Ser 
145                 150                 155                 160 
Val Ile Phe Gly Gly Phe Ser Pro Glu Ala Val Ala Gly Arg Ile Ile 
                165                 170                 175     
Asp Ser Asn Ser Arg Leu Val Ile Thr Ser Asp Glu Gly Val Arg Ala 
            180                 185                 190         
Gly Arg Ser Ile Pro Leu Lys Lys Asn Val Asp Asp Ala Leu Lys Asn 
        195                 200                 205             
Pro Asn Val Thr Ser Val Glu His Val Val Val Leu Lys Arg Thr Gly 
    210                 215                 220                 
Gly Lys Ile Asp Trp Gln Glu Gly Arg Asp Leu Trp Trp His Asp Leu 
225                 230                 235                 240 
Val Glu Gln Ala Ser Asp Gln His Gln Ala Glu Glu Met Asn Ala Glu 
                245                 250                 255     
Asp Pro Leu Phe Ile Leu Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys 
            260                 265                 270         
Gly Val Leu His Thr Thr Gly Gly Tyr Leu Val Tyr Ala Ala Leu Thr 
        275                 280                 285             
Phe Lys Tyr Val Phe Asp Tyr His Pro Gly Asp Ile Tyr Trp Cys Thr 
    290                 295                 300                 
Ala Asp Val Gly Trp Val Thr Gly His Ser Tyr Leu Leu Tyr Gly Pro 
305                 310                 315                 320 
Leu Ala Cys Gly Ala Thr Thr Leu Met Phe Glu Gly Val Pro Asn Trp 
                325                 330                 335     
Pro Thr Pro Ala Arg Met Ala Gln Val Val Asp Lys His Gln Val Asn 
            340                 345                 350         
Ile Leu Tyr Thr Ala Pro Thr Ala Ile Arg Ala Leu Met Ala Glu Gly 
        355                 360                 365             
Asp Lys Ala Ile Glu Gly Thr Asp Arg Ser Ser Leu Arg Ile Leu Gly 
    370                 375                 380                 
Ser Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Glu Trp Tyr Trp Lys 
385                 390                 395                 400 
Lys Ile Gly Asn Glu Lys Cys Pro Val Val Asp Thr Trp Trp Gln Thr 
                405                 410                 415     
Glu Thr Gly Gly Phe Met Ile Thr Pro Leu Pro Gly Ala Thr Glu Leu 
            420                 425                 430         
Lys Ala Gly Ser Ala Thr Arg Pro Phe Phe Gly Val Gln Pro Ala Leu 
        435                 440                 445             
Val Asp Asn Glu Gly Asn Pro Leu Glu Gly Ala Thr Glu Gly Ser Leu 
    450                 455                 460                 
Val Ile Thr Asp Ser Trp Pro Gly Gln Ala Arg Thr Leu Phe Gly Asp 
465                 470                 475                 480 
His Glu Arg Phe Glu Gln Thr Tyr Phe Ser Thr Phe Lys Asn Met Tyr 
                485                 490                 495     
Phe Ser Gly Asp Gly Ala Arg Arg Asp Glu Asp Gly Tyr Tyr Trp Ile 
            500                 505                 510         
Thr Gly Arg Val Asp Asp Val Leu Asn Val Ser Gly His Arg Leu Gly 
        515                 520                 525             
Thr Ala Glu Ile Glu Ser Ala Leu Val Ala His Pro Lys Ile Ala Glu 
    530                 535                 540                 
Ala Ala Val Val Gly Ile Pro His Asn Ile Lys Gly Gln Ala Ile Tyr 
545                 550                 555                 560 
Ala Tyr Val Thr Leu Asn His Gly Glu Glu Pro Ser Pro Glu Leu Tyr 
                565                 570                 575     
Ala Glu Val Arg Asn Trp Val Arg Lys Glu Ile Gly Pro Leu Ala Thr 
            580                 585                 590         
Pro Asp Val Leu His Trp Thr Asp Ser Leu Pro Lys Thr Arg Ser Gly 
        595                 600                 605             
Lys Ile Met Arg Arg Ile Leu Arg Lys Ile Ala Ala Gly Asp Thr Ser 
    610                 615                 620                 
Asn Leu Gly Asp Thr Ser Thr Leu Ala Asp Pro Gly Val Val Glu Lys 
625                 630                 635                 640 
Leu Leu Glu Glu Lys Gln Ala Ile Ala Met Pro Ser 
                645                 650         

<210> 23
<211> 566
<212> PRT
<213> Escherichia coli


<220> 
<223> strain K12

<400> 23
Met His Pro Thr Gly Pro His Leu Gly Pro Asp Val Leu Phe Arg Glu 
1               5                   10                  15      
Ser Asn Met Lys Val Thr Leu Thr Phe Asn Glu Gln Arg Arg Ala Ala 
            20                  25                  30          
Tyr Arg Gln Gln Gly Leu Trp Gly Asp Ala Ser Leu Ala Asp Tyr Trp 
        35                  40                  45              
Gln Gln Thr Ala Arg Ala Met Pro Asp Lys Ile Ala Val Val Asp Asn 
    50                  55                  60                  
His Gly Ala Ser Tyr Thr Tyr Ser Ala Leu Asp His Ala Ala Ser Cys 
65                  70                  75                  80  
Leu Ala Asn Trp Met Leu Ala Lys Gly Ile Glu Ser Gly Asp Arg Ile 
                85                  90                  95      
Ala Phe Gln Leu Pro Gly Trp Cys Glu Phe Thr Val Ile Tyr Leu Ala 
            100                 105                 110         
Cys Leu Lys Ile Gly Ala Val Ser Val Pro Leu Leu Pro Ser Trp Arg 
        115                 120                 125             
Glu Ala Glu Leu Val Trp Val Leu Asn Lys Cys Gln Ala Lys Met Phe 
    130                 135                 140                 
Phe Ala Pro Thr Leu Phe Lys Gln Thr Arg Pro Val Asp Leu Ile Leu 
145                 150                 155                 160 
Pro Leu Gln Asn Gln Leu Pro Gln Leu Gln Gln Ile Val Gly Val Asp 
                165                 170                 175     
Lys Leu Ala Pro Ala Thr Ser Ser Leu Ser Leu Ser Gln Ile Ile Ala 
            180                 185                 190         
Asp Asn Thr Ser Leu Thr Thr Ala Ile Thr Thr His Gly Asp Glu Leu 
        195                 200                 205             
Ala Ala Val Leu Phe Thr Ser Gly Thr Glu Gly Leu Pro Lys Gly Val 
    210                 215                 220                 
Met Leu Thr His Asn Asn Ile Leu Ala Ser Glu Arg Ala Tyr Cys Ala 
225                 230                 235                 240 
Arg Leu Asn Leu Thr Trp Gln Asp Val Phe Met Met Pro Ala Pro Leu 
                245                 250                 255     
Gly His Ala Thr Gly Phe Leu His Gly Val Thr Ala Pro Phe Leu Ile 
            260                 265                 270         
Gly Ala Arg Ser Val Leu Leu Asp Ile Phe Thr Pro Asp Ala Cys Leu 
        275                 280                 285             
Ala Leu Leu Glu Gln Gln Arg Cys Thr Cys Met Leu Gly Ala Thr Pro 
    290                 295                 300                 
Phe Val Tyr Asp Leu Leu Asn Val Leu Glu Lys Gln Pro Ala Asp Leu 
305                 310                 315                 320 
Ser Ala Leu Arg Phe Phe Leu Cys Gly Gly Thr Thr Ile Pro Lys Lys 
                325                 330                 335     
Val Ala Arg Glu Cys Gln Gln Arg Gly Ile Lys Leu Leu Ser Val Tyr 
            340                 345                 350         
Gly Ser Thr Glu Ser Ser Pro His Ala Val Val Asn Leu Asp Asp Pro 
        355                 360                 365             
Leu Ser Arg Phe Met His Thr Asp Gly Tyr Ala Ala Ala Gly Val Glu 
    370                 375                 380                 
Ile Lys Val Val Asp Asp Ala Arg Lys Thr Leu Pro Pro Gly Cys Glu 
385                 390                 395                 400 
Gly Glu Glu Ala Ser Arg Gly Pro Asn Val Phe Met Gly Tyr Phe Asp 
                405                 410                 415     
Glu Pro Glu Leu Thr Ala Arg Ala Leu Asp Glu Glu Gly Trp Tyr Tyr 
            420                 425                 430         
Ser Gly Asp Leu Cys Arg Met Asp Glu Ala Gly Tyr Ile Lys Ile Thr 
        435                 440                 445             
Gly Arg Lys Lys Asp Ile Ile Val Arg Gly Gly Glu Asn Ile Ser Ser 
    450                 455                 460                 
Arg Glu Val Glu Asp Ile Leu Leu Gln His Pro Lys Ile His Asp Ala 
465                 470                 475                 480 
Cys Val Val Ala Met Ser Asp Glu Arg Leu Gly Glu Arg Ser Cys Ala 
                485                 490                 495     
Tyr Val Val Leu Lys Ala Pro His His Ser Leu Ser Leu Glu Glu Val 
            500                 505                 510         
Val Ala Phe Phe Ser Arg Lys Arg Val Ala Lys Tyr Lys Tyr Pro Glu 
        515                 520                 525             
His Ile Val Val Ile Glu Lys Leu Pro Arg Thr Thr Ser Gly Lys Ile 
    530                 535                 540                 
Gln Lys Phe Leu Leu Arg Lys Asp Ile Met Arg Arg Leu Thr Gln Asp 
545                 550                 555                 560 
Val Cys Glu Glu Ile Glu 
                565     

<210> 24
<211> 561
<212> PRT
<213> Escherichia coli


<220> 
<223> strain K12

<400> 24
Met Lys Lys Val Trp Leu Asn Arg Tyr Pro Ala Asp Val Pro Thr Glu 
1               5                   10                  15      
Ile Asn Pro Asp Arg Tyr Gln Ser Leu Val Asp Met Phe Glu Gln Ser 
            20                  25                  30          
Val Ala Arg Tyr Ala Asp Gln Pro Ala Phe Val Asn Met Gly Glu Val 
        35                  40                  45              
Met Thr Phe Arg Lys Leu Glu Glu Arg Ser Arg Ala Phe Ala Ala Tyr 
    50                  55                  60                  
Leu Gln Gln Gly Leu Gly Leu Lys Lys Gly Asp Arg Val Ala Leu Met 
65                  70                  75                  80  
Met Pro Asn Leu Leu Gln Tyr Pro Val Ala Leu Phe Gly Ile Leu Arg 
                85                  90                  95      
Ala Gly Met Ile Val Val Asn Val Asn Pro Leu Tyr Thr Pro Arg Glu 
            100                 105                 110         
Leu Glu His Gln Leu Asn Asp Ser Gly Ala Ser Ala Ile Val Ile Val 
        115                 120                 125             
Ser Asn Phe Ala His Thr Leu Glu Lys Val Val Asp Lys Thr Ala Val 
    130                 135                 140                 
Gln His Val Ile Leu Thr Arg Met Gly Asp Gln Leu Ser Thr Ala Lys 
145                 150                 155                 160 
Gly Thr Val Val Asn Phe Val Val Lys Tyr Ile Lys Arg Leu Val Pro 
                165                 170                 175     
Lys Tyr His Leu Pro Asp Ala Ile Ser Phe Arg Ser Ala Leu His Asn 
            180                 185                 190         
Gly Tyr Arg Met Gln Tyr Val Lys Pro Glu Leu Val Pro Glu Asp Leu 
        195                 200                 205             
Ala Phe Leu Gln Tyr Thr Gly Gly Thr Thr Gly Val Ala Lys Gly Ala 
    210                 215                 220                 
Met Leu Thr His Arg Asn Met Leu Ala Asn Leu Glu Gln Val Asn Ala 
225                 230                 235                 240 
Thr Tyr Gly Pro Leu Leu His Pro Gly Lys Glu Leu Val Val Thr Ala 
                245                 250                 255     
Leu Pro Leu Tyr His Ile Phe Ala Leu Thr Ile Asn Cys Leu Leu Phe 
            260                 265                 270         
Ile Glu Leu Gly Gly Gln Asn Leu Leu Ile Thr Asn Pro Arg Asp Ile 
        275                 280                 285             
Pro Gly Leu Val Lys Glu Leu Ala Lys Tyr Pro Phe Thr Ala Ile Thr 
    290                 295                 300                 
Gly Val Asn Thr Leu Phe Asn Ala Leu Leu Asn Asn Lys Glu Phe Gln 
305                 310                 315                 320 
Gln Leu Asp Phe Ser Ser Leu His Leu Ser Ala Gly Gly Gly Met Pro 
                325                 330                 335     
Val Gln Gln Val Val Ala Glu Arg Trp Val Lys Leu Thr Gly Gln Tyr 
            340                 345                 350         
Leu Leu Glu Gly Tyr Gly Leu Thr Glu Cys Ala Pro Leu Val Ser Val 
        355                 360                 365             
Asn Pro Tyr Asp Ile Asp Tyr His Ser Gly Ser Ile Gly Leu Pro Val 
    370                 375                 380                 
Pro Ser Thr Glu Ala Lys Leu Val Asp Asp Asp Asp Asn Glu Val Pro 
385                 390                 395                 400 
Pro Gly Gln Pro Gly Glu Leu Cys Val Lys Gly Pro Gln Val Met Leu 
                405                 410                 415     
Gly Tyr Trp Gln Arg Pro Asp Ala Thr Asp Glu Ile Ile Lys Asn Gly 
            420                 425                 430         
Trp Leu His Thr Gly Asp Ile Ala Val Met Asp Glu Glu Gly Phe Leu 
        435                 440                 445             
Arg Ile Val Asp Arg Lys Lys Asp Met Ile Leu Val Ser Gly Phe Asn 
    450                 455                 460                 
Val Tyr Pro Asn Glu Ile Glu Asp Val Val Met Gln His Pro Gly Val 
465                 470                 475                 480 
Gln Glu Val Ala Ala Val Gly Val Pro Ser Gly Ser Ser Gly Glu Ala 
                485                 490                 495     
Val Lys Ile Phe Val Val Lys Lys Asp Pro Ser Leu Thr Glu Glu Ser 
            500                 505                 510         
Leu Val Thr Phe Cys Arg Arg Gln Leu Thr Gly Tyr Lys Val Pro Lys 
        515                 520                 525             
Leu Val Glu Phe Arg Asp Glu Leu Pro Lys Ser Asn Val Gly Lys Ile 
    530                 535                 540                 
Leu Arg Arg Glu Leu Arg Asp Glu Ala Arg Gly Lys Val Asp Asn Lys 
545                 550                 555                 560 
Ala 
    

<210> 25
<211> 512
<212> PRT
<213> Hypocrea atroviridis


<220> 
<223> Hypocrea atroviridis (strain ATCC 20476)

<400> 25
Met Ser Ser Thr Thr Tyr Lys Ser Glu Ala Phe Asp Pro Glu Pro Pro 
1               5                   10                  15      
His Leu Ser Phe Arg Ser Phe Val Glu Ala Leu Arg Gln Asp Asn Asp 
            20                  25                  30          
Leu Val Asp Ile Asn Glu Pro Val Asp Pro Asp Leu Glu Ala Ala Ala 
        35                  40                  45              
Ile Thr Arg Leu Val Cys Glu Thr Asp Asp Lys Ala Pro Leu Phe Asn 
    50                  55                  60                  
Asn Val Ile Gly Ala Lys Asp Gly Leu Trp Arg Ile Leu Gly Ala Pro 
65                  70                  75                  80  
Ala Ser Leu Arg Ser Ser Pro Lys Glu Arg Phe Gly Arg Leu Ala Arg 
                85                  90                  95      
His Leu Ala Leu Pro Pro Thr Ala Ser Ala Lys Asp Ile Leu Asp Lys 
            100                 105                 110         
Met Leu Ser Ala Asn Ser Ile Pro Pro Ile Glu Pro Val Ile Val Pro 
        115                 120                 125             
Thr Gly Pro Val Lys Glu Asn Ser Ile Glu Gly Glu Asn Ile Asp Leu 
    130                 135                 140                 
Glu Ala Leu Pro Ala Pro Met Val His Gln Ser Asp Gly Gly Lys Tyr 
145                 150                 155                 160 
Ile Gln Thr Tyr Gly Met His Val Ile Gln Ser Pro Asp Gly Cys Trp 
                165                 170                 175     
Thr Asn Trp Ser Ile Ala Arg Ala Met Val Ser Gly Lys Arg Thr Leu 
            180                 185                 190         
Ala Gly Leu Val Ile Ser Pro Gln His Ile Arg Lys Ile Gln Asp Gln 
        195                 200                 205             
Trp Arg Ala Ile Gly Gln Glu Glu Ile Pro Trp Ala Leu Ala Phe Gly 
    210                 215                 220                 
Val Pro Pro Thr Ala Ile Met Ala Ser Ser Met Pro Ile Pro Asp Gly 
225                 230                 235                 240 
Val Ser Glu Ala Gly Tyr Val Gly Ala Ile Ala Gly Glu Pro Ile Lys 
                245                 250                 255     
Leu Val Lys Cys Asp Thr Asn Asn Leu Tyr Val Pro Ala Asn Ser Glu 
            260                 265                 270         
Ile Val Leu Glu Gly Thr Leu Ser Thr Thr Lys Met Ala Pro Glu Gly 
        275                 280                 285             
Pro Phe Gly Glu Met His Gly Tyr Val Tyr Pro Gly Glu Ser His Pro 
    290                 295                 300                 
Gly Pro Val Tyr Thr Val Asn Lys Ile Thr Tyr Arg Asn Asn Ala Ile 
305                 310                 315                 320 
Leu Pro Met Ser Ala Cys Gly Arg Leu Thr Asp Glu Thr Gln Thr Met 
                325                 330                 335     
Ile Gly Thr Leu Ala Ala Ala Glu Ile Arg Gln Leu Cys Gln Asp Ala 
            340                 345                 350         
Gly Leu Pro Ile Thr Asp Ala Phe Ala Pro Phe Val Gly Gln Ala Thr 
        355                 360                 365             
Trp Val Ala Leu Lys Val Asp Thr Lys Arg Leu Arg Ala Met Lys Thr 
    370                 375                 380                 
Asn Gly Lys Ala Phe Ala Lys Arg Val Gly Asp Val Val Phe Thr Gln 
385                 390                 395                 400 
Lys Pro Gly Phe Thr Ile His Arg Leu Ile Leu Val Gly Asp Asp Ile 
                405                 410                 415     
Asp Val Tyr Asp Asp Lys Asp Val Met Trp Ala Phe Thr Thr Arg Cys 
            420                 425                 430         
Arg Pro Gly Thr Asp Glu Val Phe Phe Asp Asp Val Val Gly Phe Gln 
        435                 440                 445             
Leu Ile Pro Tyr Met Ser His Gly Asn Ala Glu Ala Ile Lys Gly Gly 
    450                 455                 460                 
Lys Val Val Ser Asp Ala Leu Leu Thr Ala Glu Tyr Thr Thr Gly Lys 
465                 470                 475                 480 
Asp Trp Glu Ser Ala Asp Phe Lys Asn Ser Tyr Pro Lys Ser Ile Gln 
                485                 490                 495     
Asp Lys Val Leu Asn Ser Trp Glu Arg Leu Gly Phe Lys Lys Leu Asp 
            500                 505                 510         



<210> 26
<211> 501
<212> PRT
<213> Streptomyces sp. 769


<220> 
<223> Streptomyces sp. 769

<400> 26
Met Tyr Val Gln Met Val Phe Val Lys Glu Val Pro Val Gln His Pro 
1               5                   10                  15      
Ser Asp Leu Arg Glu His Ile Glu Ala Leu Glu Lys Leu Gly Asp Leu 
            20                  25                  30          
Asp Arg Val His Asp Glu Val Asp Trp Asn Leu Glu Ala Ala Ala Gln 
        35                  40                  45              
Thr Arg Tyr Ser Thr Glu His His Leu Pro Ala Pro Leu Phe Glu Asn 
    50                  55                  60                  
Val Ala Gly Val Ala Glu Gly Phe Arg Leu Leu Gly Ala Pro Ala Ala 
65                  70                  75                  80  
Leu Ser Ser Asp Pro Ser Arg Pro Tyr Ala Arg Val Ala Leu Ser Val 
                85                  90                  95      
Gly Leu Arg Pro Glu Ala Thr Gly Arg Glu Val Val Glu His Leu Val 
            100                 105                 110         
Ala Ala Arg His Arg Pro Gly Val Pro Pro Val Ala Val Ala Ala Glu 
        115                 120                 125             
Ala Ala Pro Val Lys Ala Asn Val Leu Leu Gly Asp Glu Ala Asp Leu 
    130                 135                 140                 
Asn Arg Phe Pro Val Pro Phe Val His Glu Gly Asp Gly Asn Arg Tyr 
145                 150                 155                 160 
Ala Asn Thr Tyr Gly Val Ile Ile Ala Gln Thr Pro Asp Gly Ser Trp 
                165                 170                 175     
Thr Asn Trp Ser Ile Ala Arg Ile Met Met Ile Asp Gly Lys His Met 
            180                 185                 190         
Thr Gly Leu Val Met His Pro Gln His Ile Ala Gln Val Trp Gln Gln 
        195                 200                 205             
Trp Ala Asp Leu Gly Lys Pro Met Pro Tyr Ala Leu Val Gln Gly Gly 
    210                 215                 220                 
Asp Pro Ala Ile Pro Tyr Val Gly Gly Ile Pro Ile Gly Asp Gly Val 
225                 230                 235                 240 
Ala Glu Ser Ala Tyr Ile Gly Ala Leu Ile Gly Arg Pro Leu Glu Val 
                245                 250                 255     
Val Lys Ala Glu Leu Ser Asp Leu Met Val Pro Ala Gly Ala Glu Ile 
            260                 265                 270         
Val Ile Glu Gly His Leu Ser Val Gln Arg Asp Gly Val Glu Gly Pro 
        275                 280                 285             
Phe Gly Glu Phe Ala Gly Tyr Ile Pro Arg Glu Thr Ser Leu Gln Pro 
    290                 295                 300                 
Val Tyr Thr Val Glu Ala Ile Thr His Arg Asp Ala Pro Ile Trp Pro 
305                 310                 315                 320 
Leu Val Ala Glu Gly Lys Pro Thr Asp Asp Phe His Thr Val Thr Gly 
                325                 330                 335     
Ile Gly Glu Ala Ala Gly Ala Leu Asp Ala Ile Arg Glu Ala Gly Leu 
            340                 345                 350         
Pro Ala Ala Ser Ala Trp Ala Pro Leu Ser Ala Ala Ser His Trp Leu 
        355                 360                 365             
Val Val Thr Ala Pro Gly Asn Trp Arg Glu Leu Leu Pro Gly Val Ser 
    370                 375                 380                 
Glu Glu Gln Tyr Ala Arg Arg Val Gly Glu Ala Val Phe Gly Thr Lys 
385                 390                 395                 400 
Phe Gly Ser Cys Leu Pro Gln Val Phe Leu Leu Asp Asp Asp Phe Asp 
                405                 410                 415     
Pro Thr Asp Asp Ala Asp Leu Leu Trp Ala Leu Ala Thr Arg Val His 
            420                 425                 430         
Pro Asp Gly Arg Val Val Arg Phe Glu Asp Gly Pro Val Leu Pro Leu 
        435                 440                 445             
Leu Thr Cys Tyr Thr Pro Gln Glu Arg His Ala Ala Arg Ala Thr Lys 
    450                 455                 460                 
Val Val His Glu Ala Leu Leu Ser Ala Pro Gly Glu Arg Glu Pro Gln 
465                 470                 475                 480 
Ser Thr Phe Ala Asp Ala Tyr Pro Ala Glu Val Arg Ala Lys Val Arg 
                485                 490                 495     
Ala Arg Tyr Pro Asn 
            500     

