                         SEQUENCE LISTING

<110>  Aravive Inc.
 
<120>  METHODS OF TREATING IMMUNOGLOBULIN A NEPHROPATHY (IGAN) USING AXL DECOY RECEPTORS

<130>  CACAB1.0010WO

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Arg Val Pro Leu Ala Trp Cys Leu Ala Leu Cys Gly Trp Ala 
1               5                   10                  15      


Cys Met Ala Pro Arg Gly Thr Gln Ala Glu Glu Ser Pro Phe Val Gly 
            20                  25                  30          


Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu Arg 
        35                  40                  45              


Cys Gln Leu Gln Val Gln Gly Glu Pro Pro Glu Val His Trp Leu Arg 
    50                  55                  60                  


Asp Gly Gln Ile Leu Glu Leu Ala Asp Ser Thr Gln Thr Gln Val Pro 
65                  70                  75                  80  


Leu Gly Glu Asp Glu Gln Asp Asp Trp Ile Val Val Ser Gln Leu Arg 
                85                  90                  95      


Ile Thr Ser Leu Gln Leu Ser Asp Thr Gly Gln Tyr Gln Cys Leu Val 
            100                 105                 110         


Phe Leu Gly His Gln Thr Phe Val Ser Gln Pro Gly Tyr Val Gly Leu 
        115                 120                 125             


Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Arg Thr Val Ala 
    130                 135                 140                 


Ala Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro Glu 
145                 150                 155                 160 


Pro Val Asp Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Thr Ala 
                165                 170                 175     


Pro Gly His Gly Pro Gln Arg Ser Leu His Val Pro Gly Leu Asn Lys 
            180                 185                 190         


Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr Thr 
        195                 200                 205             


Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Gln Pro Arg Asn Leu 
    210                 215                 220                 


His Leu Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr Pro 
225                 230                 235                 240 


Gly Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Thr Leu Gln Ala Val 
                245                 250                 255     


Leu Ser Asn Asp Gly Met Gly Ile Gln Ala Gly Glu Pro Asp Pro Pro 
            260                 265                 270         


Glu Glu Pro Leu Thr Ser Gln Ala Ser Val Pro Pro His Gln Leu Arg 
        275                 280                 285             


Leu Gly Ser Leu His Pro His Thr Pro Tyr His Ile Arg Val Ala Cys 
    290                 295                 300                 


Thr Ser Ser Gln Gly Pro Ser Ser Trp Thr His Trp Leu Pro Val Glu 
305                 310                 315                 320 


Thr Pro Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Ile Ser Ala Thr 
                325                 330                 335     


Arg Asn Gly Ser Gln Ala Phe Val His Trp Gln Glu Pro Arg Ala Pro 
            340                 345                 350         


Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Gln Gly Gln Asp 
        355                 360                 365             


Thr Pro Glu Val Leu Met Asp Ile Gly Leu Arg Gln Glu Val Thr Leu 
    370                 375                 380                 


Glu Leu Gln Gly Asp Gly Ser Val Ser Asn Leu Thr Val Cys Val Ala 
385                 390                 395                 400 


Ala Tyr Thr Ala Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro Leu 
                405                 410                 415     


Glu Ala Trp Arg Pro Gly Gln Ala Gln Pro Val His Gln Leu Val Lys 
            420                 425                 430         


Glu Pro Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu 
        435                 440                 445             


Gly Ala Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu 
    450                 455                 460                 


Val His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro 
465                 470                 475                 480 


Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser 
                485                 490                 495     


Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser 
            500                 505                 510         


Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys 
        515                 520                 525             


Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met 
    530                 535                 540                 


Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys 
545                 550                 555                 560 


Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu 
                565                 570                 575     


Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg 
            580                 585                 590         


Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala 
        595                 600                 605             


Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe 
    610                 615                 620                 


Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln 
625                 630                 635                 640 


Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu 
                645                 650                 655     


Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met 
            660                 665                 670         


Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys 
        675                 680                 685             


Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met 
    690                 695                 700                 


Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr 
705                 710                 715                 720 


Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala 
                725                 730                 735     


Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr 
            740                 745                 750         


Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu 
        755                 760                 765             


Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln 
    770                 775                 780                 


Asp Arg Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu 
785                 790                 795                 800 


Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn 
                805                 810                 815     


Met Asp Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly 
            820                 825                 830         


Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu 
        835                 840                 845             


Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser 
    850                 855                 860                 


Thr Thr Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala 
865                 870                 875                 880 


Pro Gly Gln Glu Asp Gly Ala 
                885         


<210>  2
<211>  426
<212>  PRT
<213>  Artificial

<220>
<223>  soluble AXL polypeptide-Fc fusion

<400>  2

Glu Glu Ser Pro Phe Val Ser Asn Pro Gly Asn Ile Thr Gly Ala Arg 
1               5                   10                  15      


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
            20                  25                  30          


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Val Asp 
        35                  40                  45              


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Gly Asp Trp 
    50                  55                  60                  


Ile Val Ala Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
65                  70                  75                  80  


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
                85                  90                  95      


Gln Pro Gly Tyr Val Arg Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
            100                 105                 110         


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
        115                 120                 125             


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
    130                 135                 140                 


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
145                 150                 155                 160 


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
                165                 170                 175     


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
            180                 185                 190         


Pro Gln Gln Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
        195                 200                 205             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    210                 215                 220                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
225                 230                 235                 240 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                245                 250                 255     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            260                 265                 270         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        275                 280                 285             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    290                 295                 300                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
305                 310                 315                 320 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                325                 330                 335     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            340                 345                 350         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        355                 360                 365             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    370                 375                 380                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
385                 390                 395                 400 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                405                 410                 415     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425     


