                         SEQUENCE LISTING

<110>  UNIVERSITY OF VIRGINIA PATENT FOUNDATION
       GORDON, LAURIE W.
       BRAYMAN, KENNETH
       CHHABRA, PREETI
       MA, MINGYANG
       KARINA, TEIXEIRA
       GADEK, THOMAS R.
 
<120>  COMPOSITIONS AND METHODS FOR PROMOTING ISLET VIABILITY AND 
       ENHANCING INSULIN SECRETION

<130>  3062/118 PCT

<150>  US 62/817,790
<151>  2019-03-13

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  1

Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu Lys 
1               5                   10                  15      


Lys Phe Ser 
            


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  2

Cys Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu 
1               5                   10                  15      


Lys Lys Phe Ser 
            20  


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  3

Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu Lys 
1               5                   10                  15      


Lys Phe Ser Cys 
            20  


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  4

Cys Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu 
1               5                   10                  15      


Lys Lys Phe Ser Cys 
            20      


<210>  5
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  5

Lys Asn Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu Lys 
1               5                   10                  15      


Lys Phe Ser Leu Leu Lys Pro Trp Ala 
            20                  25  


<210>  6
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  6

Cys Lys Asn Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu 
1               5                   10                  15      


Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
            20                  25      


<210>  7
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  7

Lys Asn Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu Lys 
1               5                   10                  15      


Lys Phe Ser Leu Leu Lys Pro Trp Ala Cys 
            20                  25      


<210>  8
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  8

Cys Lys Asn Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu 
1               5                   10                  15      


Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala Cys 
            20                  25          


<210>  9
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  9

Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Asn Lys Leu Leu Lys 
1               5                   10                  15      


Lys Phe Ser Leu Leu Lys Pro Trp Ala 
            20                  25  


<210>  10
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  10

Cys Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Asn Lys Leu Leu 
1               5                   10                  15      


Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
            20                  25      


<210>  11
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  11

Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Asn Lys Leu Leu Lys 
1               5                   10                  15      


Lys Phe Ser Leu Leu Lys Pro Trp Ala Cys 
            20                  25      


<210>  12
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  12

Cys Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Asn Lys Leu Leu 
1               5                   10                  15      


Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala Cys 
            20                  25          


<210>  13
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  13

Lys Lys Leu Phe Gly Gly Arg Asn Asp Val Leu Arg Gln Met Met Asp 
1               5                   10                  15      


Arg Leu Gly Pro Lys Phe Asn Leu Phe 
            20                  25  


<210>  14
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  14

Cys Lys Lys Leu Phe Gly Gly Arg Asn Asp Val Leu Arg Gln Met Met 
1               5                   10                  15      


Asp Arg Leu Gly Pro Lys Phe Asn Leu Phe 
            20                  25      


<210>  15
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  15

Lys Lys Leu Phe Gly Gly Arg Asn Asp Val Leu Arg Gln Met Met Asp 
1               5                   10                  15      


Arg Leu Gly Pro Lys Phe Asn Leu Phe Cys 
            20                  25      


<210>  16
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  16

Cys Lys Lys Leu Phe Gly Gly Arg Asn Asp Val Leu Arg Gln Met Met 
1               5                   10                  15      


Asp Arg Leu Gly Pro Lys Phe Asn Leu Phe Cys 
            20                  25          


<210>  17
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  17

Lys Lys Leu Phe Gly Gly Arg Asn Asp Val Leu Arg Asn Met Met Asp 
1               5                   10                  15      


Arg Leu Gly Pro Lys Phe Asn Leu Phe 
            20                  25  


<210>  18
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  18

Cys Lys Lys Leu Phe Gly Gly Arg Asn Asp Val Leu Arg Asn Met Met 
1               5                   10                  15      


Asp Arg Leu Gly Pro Lys Phe Asn Leu Phe 
            20                  25      


<210>  19
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  19

Lys Lys Leu Phe Gly Gly Arg Asn Asp Val Leu Arg Asn Met Met Asp 
1               5                   10                  15      


Arg Leu Gly Pro Lys Phe Asn Leu Phe Cys 
            20                  25      


<210>  20
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  20

Cys Lys Lys Leu Phe Gly Gly Arg Asn Asp Val Leu Arg Asn Met Met 
1               5                   10                  15      


Asp Arg Leu Gly Pro Lys Phe Asn Leu Phe Cys 
            20                  25          


<210>  21
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  21

Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg Lys 
1               5                   10                  15      


Asn Trp His Ala Gln Leu Phe Val Leu 
            20                  25  


<210>  22
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  22

Cys Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg 
1               5                   10                  15      


Lys Asn Trp His Ala Gln Leu Phe Val Leu 
            20                  25      


<210>  23
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  23

Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg Lys 
1               5                   10                  15      


Asn Trp His Ala Gln Leu Phe Val Leu Cys 
            20                  25      


<210>  24
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  24

Cys Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg 
1               5                   10                  15      


Lys Asn Trp His Ala Gln Leu Phe Val Leu Cys 
            20                  25          


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  25

Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly 
1               5                   10      


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  26

Cys Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  27

Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Cys 
1               5                   10          


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  28

Cys Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Cys 
1               5                   10              


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  29

Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg 
1               5                   10                  15  


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  30

Cys Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg 
1               5                   10                  15      


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  31

Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg Cys 
1               5                   10                  15      


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  32

Cys Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg 
1               5                   10                  15      


Cys 
    


<210>  33
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  33

Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg Lys 
1               5                   10                  15      


Asn Trp His 
            


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  34

Cys Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg 
1               5                   10                  15      


Lys Asn Trp His 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  35

Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg Lys 
1               5                   10                  15      


Asn Trp His Cys 
            20  


<210>  36
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  36

Cys Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg 
1               5                   10                  15      


Lys Asn Trp His Cys 
            20      


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  37

Gly Lys Asn Arg Arg Lys Asn Trp His Ala Gln Leu Phe Val Leu 
1               5                   10                  15  


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  38

Cys Gly Lys Asn Arg Arg Lys Asn Trp His Ala Gln Leu Phe Val Leu 
1               5                   10                  15      


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  39

Gly Lys Asn Arg Arg Lys Asn Trp His Ala Gln Leu Phe Val Leu Cys 
1               5                   10                  15      


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  40

Cys Gly Lys Asn Arg Arg Lys Asn Trp His Ala Gln Leu Phe Val Leu 
1               5                   10                  15      


Cys 
    


<210>  41
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  41

Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg Lys 
1               5                   10                  15      


Asn Trp His Ala Asn Leu Phe Val Leu 
            20                  25  


<210>  42
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  42

Cys Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg 
1               5                   10                  15      


Lys Asn Trp His Ala Asn Leu Phe Val Leu 
            20                  25      


<210>  43
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  43

Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg Lys 
1               5                   10                  15      


Asn Trp His Ala Asn Leu Phe Val Leu Cys 
            20                  25      


<210>  44
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  44

Cys Lys Arg Phe Tyr Lys Arg Gly Ala Glu Leu Gly Lys Asn Arg Arg 
1               5                   10                  15      


Lys Asn Trp His Ala Asn Leu Phe Val Leu Cys 
            20                  25          


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  45

Gly Lys Asn Arg Arg Lys Asn Trp His Ala Gln Leu Phe Val Leu 
1               5                   10                  15  


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  46

Cys Gly Lys Asn Arg Arg Lys Asn Trp His Ala Gln Leu Phe Val Leu 
1               5                   10                  15      


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  47

Gly Lys Asn Arg Arg Lys Asn Trp His Ala Gln Leu Phe Val Leu Cys 
1               5                   10                  15      


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  48

Cys Gly Lys Asn Arg Arg Lys Asn Trp His Ala Gln Leu Phe Val Leu 
1               5                   10                  15      


Cys 
    


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  49

Ala Gln Lys Leu Leu Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
1               5                   10                  15  


<210>  50
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  50

Cys Ala Gln Lys Leu Leu Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
1               5                   10                  15      


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  51

Ala Gln Lys Leu Leu Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala Cys 
1               5                   10                  15      


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  52

Cys Ala Gln Lys Leu Leu Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
1               5                   10                  15      


Cys 
    


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  53

Ala Asn Lys Leu Leu Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
1               5                   10                  15  


<210>  54
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  54

Cys Ala Asn Lys Leu Leu Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
1               5                   10                  15      


<210>  55
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  55

Ala Asn Lys Leu Leu Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala Cys 
1               5                   10                  15      


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  56

Cys Ala Asn Lys Leu Leu Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
1               5                   10                  15      


Cys 
    


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  57

Ala Gln Lys Leu Leu Lys Lys Phe Ser 
1               5                   


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  58

Cys Ala Gln Lys Leu Leu Lys Lys Phe Ser 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  59

Ala Gln Lys Leu Leu Lys Lys Phe Ser Cys 
1               5                   10  


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  60

Cys Ala Gln Lys Leu Leu Lys Lys Phe Ser Cys 
1               5                   10      


<210>  61
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Lys Phe Thr Thr Leu Leu Phe Leu Ala Ala Val Ala Gly Ala Leu 
1               5                   10                  15      


Val Tyr Ala Glu Asp Ala Ser Ser Asp Ser Thr Gly Ala Asp Pro Ala 
            20                  25                  30          


Gln Glu Ala Gly Thr Ser Lys Pro Asn Glu Glu Ile Ser Gly Pro Ala 
        35                  40                  45              


Glu Pro Ala Ser Pro Pro Glu Thr Thr Thr Thr Ala Gln Glu Thr Ser 
    50                  55                  60                  


Ala Ala Ala Val Gln Gly Thr Ala Lys Val Thr Ser Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Asn Pro Leu Lys Ser Ile Val Glu Lys Ser Ile Leu Leu Thr Glu 
                85                  90                  95      


Gln Ala Leu Ala Lys Ala Gly Lys Gly Met His Gly Gly Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu 
        115                 120                 125             


Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
    130                 135             


<210>  62
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  62

Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu Lys 
1               5                   10                  15      


Lys Phe Ser 
            


<210>  63
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide

<400>  63

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


