                         SEQUENCE LISTING

<110>  RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
 
<120>  SYNCYTIAL ONCOLYTIC HERPES SIMPLEX MUTANTS AS POTENT CANCER 
       THERAPEUTICS

<130>  106887-7660

<150>  62/932,725
<151>  2019-11-08

<150>  62/818,577
<151>  2019-03-14

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  mutation
<222>  (356)..(356)
<223>  c356a

<400>  1
atggcccgcc gccgccgcca tcgcggcccc cgccgccccc ggccgcccgg gcccacgggc       60

gcggtcccaa ccgcacagtc ccaggtaacc tccacgccca actcggaacc cgtggtcagg      120

agcgcgcccg cggccgcccc gccgccgccc cccgccagtg ggcccccgcc ttcttgttcg      180

ctgctgctgc gccagtggct ccacgttccc gagtccgcgt ccgacgacga cgacgacgac      240

tggccggaca gccccccgcc cgagccggcg ccagaggccc ggcccaccgc cgccgccccc      300

cgcccccggt ccccaccgcc cggcgcgggc ccggggggcg gggctaaccc ctcccacccc      360

ccctcacgcc ccttccgcct tccgccgcgc ctcgccctcc gcctgcgcgt caccgcagag      420

cacctggcgc gcctgcgcct gcgacgcgcg ggcggggagg gggcgccgaa gccccccgcg      480

acccccgcga cccccgcgac ccccacgcgg gtgcgcttct cgccccacgt ccgggtgcgc      540

cacctggtgg tctgggcctc ggccgcccgc ctggcgcgcc gcggctcgtg ggcccgcgag      600

cgggccgacc gggctcggtt ccggcgccgg gtggcggagg ccgaggcggt catcgggccg      660

tgcctggggc ccgaggcccg tgcccgggcc ctggcccgcg gagccggccc ggcgaactcg      720

gtctaa                                                                 726


<210>  2
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  P119H mutation

<400>  2

Met Ala Arg Arg Arg Arg His Arg Gly Pro Arg Arg Pro Arg Pro Pro 
1               5                   10                  15      


Gly Pro Thr Gly Ala Val Pro Thr Ala Gln Ser Gln Val Thr Ser Thr 
            20                  25                  30          


Pro Asn Ser Glu Pro Val Val Arg Ser Ala Pro Ala Ala Ala Pro Pro 
        35                  40                  45              


Pro Pro Pro Ala Ser Gly Pro Pro Pro Ser Cys Ser Leu Leu Leu Arg 
    50                  55                  60                  


Gln Trp Leu His Val Pro Glu Ser Ala Ser Asp Asp Asp Asp Asp Asp 
65                  70                  75                  80  


Trp Pro Asp Ser Pro Pro Pro Glu Pro Ala Pro Glu Ala Arg Pro Thr 
                85                  90                  95      


Ala Ala Ala Pro Arg Pro Arg Ser Pro Pro Pro Gly Ala Gly Pro Gly 
            100                 105                 110         


Gly Gly Ala Asn Pro Ser His Pro Pro Ser Arg Pro Phe Arg Leu Pro 
        115                 120                 125             


Pro Arg Leu Ala Leu Arg Leu Arg Val Thr Ala Glu His Leu Ala Arg 
    130                 135                 140                 


Leu Arg Leu Arg Arg Ala Gly Gly Glu Gly Ala Pro Lys Pro Pro Ala 
145                 150                 155                 160 


Thr Pro Ala Thr Pro Ala Thr Pro Thr Arg Val Arg Phe Ser Pro His 
                165                 170                 175     


Val Arg Val Arg His Leu Val Val Trp Ala Ser Ala Ala Arg Leu Ala 
            180                 185                 190         


Arg Arg Gly Ser Trp Ala Arg Glu Arg Ala Asp Arg Ala Arg Phe Arg 
        195                 200                 205             


Arg Arg Val Ala Glu Ala Glu Ala Val Ile Gly Pro Cys Leu Gly Pro 
    210                 215                 220                 


Glu Ala Arg Ala Arg Ala Leu Ala Arg Gly Ala Gly Pro Ala Asn Ser 
225                 230                 235                 240 


Val 
    


<210>  3
<211>  846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  3
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagaag      720

cttagccatg gcttcccgcc ggaggtggag gagcaggatg atggcacgct gcccatgtct      780

tgtgcccagg agagcgggat ggaccgtcac cctgcagcct gtgcttctgc taggatcaat      840

gtgtag                                                                 846


<210>  4
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  4

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Lys 
225                 230                 235                 240 


Leu Ser His Gly Phe Pro Pro Glu Val Glu Glu Gln Asp Asp Gly Thr 
                245                 250                 255     


Leu Pro Met Ser Cys Ala Gln Glu Ser Gly Met Asp Arg His Pro Ala 
            260                 265                 270         


Ala Cys Ala Ser Ala Arg Ile Asn Val 
        275                 280     


<210>  5
<211>  767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  5
atggcccgcc gccgccgcca tcgcggcccc cgccgccccc ggccgcccgg gcccacgggc       60

gccgtcccaa ccgcacagtc ccaggtaacc tagactagtc tagcgtaacc tccacgccca      120

actcggaacc cgcggtcagg agcgcgcccg cggccgcccc gccgccgccc cccgccggtg      180

ggcccccgcc ttcttgttcg ctgctgctgc gccagtggct ccacgttccc gagtccgcgt      240

ccgacaacga cgatgacgac gactggccgg acagcccccc gcccgagccg gcgccagagg      300

cccggcccac cgccgccgcc ccccggcccc ggcccccacc gcccggcgtg ggcccggggg      360

gcggggctga cccctcccac cccccctcgc gccccttccg ccttccgccg cgcctcgccc      420

tccgcctgcg cgtcaccgcg gagcacctgg cgcgcctgcg cctgcgacgc gcgggcgggg      480

agggggcgcc ggagcccccc gcgacccccg cgacccccgc gacccccgcg acccccgcga      540

cccccgcgcg ggtgcgcttc tcgccccacg tccgggtgcg ccacctggtg gtctgggcct      600

cggccgcccg cctggcgcgc cgcggctcgt gggcccgcga gcgggccgac cgggctcggt      660

tccggcgccg ggtggcggag gccgaggcgg tcatcgggcc gtgcctgggg cccgaggccc      720

gtgcccgggc cctggcccgc ggagccggcc cggcgaactc ggtctaa                    767


<210>  6
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  6

Met Ala Arg Arg Arg Arg His Arg Gly Pro Arg Arg Pro Arg Pro Pro 
1               5                   10                  15      


Gly Pro Thr Gly Ala Val Pro Thr Ala Gln Ser Gln Val Thr 
            20                  25                  30  


<210>  7
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  7
atggcccgcc gccgccatcg cggcccccgc cgcccccggc cgcccgggcc cacgggcgcg       60

gtcccaaccg cacagtccca ggtaacctcc acgcccaact cggaacccgt ggtcaggagc      120

gcgcccgcgg ccgccccgcc gccgcccccc gccagtgggc ccccgccttc ttgttcgctg      180

ctgctgcgcc agtggctcca cgttcccgag tccgcgtccg acgacgacga cgacgactgg      240

ccggacagcc ccccgcccga gccggcgcca gaggcccggc ccaccgccgc cgccccccgc      300

ccccggtccc caccgcccgg cgcgggcccg gggggcgggg ctaacccctc cccccccccc      360

tcacgcccct tccgccttcc gccgcgcctc gccctccgcc tgcgcgtcac cgcagagcac      420

ctggcgcgcc tgcgcctgcg acgcgcgggc ggggaggggg cgccgaagcc ccccgcgacc      480

cccgcgaccc ccgcgacccc cacgcgggtg cgcttctcgc cccacgtccg ggtgcgccac      540

ctggtggtct gggcctcggc cgcccgcctg gcgcgccgcg gctcgtgggc ccgcgagcgg      600

gccgaccggg ctcggttccg gcgccgggtg gcggaggccg aggcggtcat cgggccgtgc      660

ctggggcccg aggcccgtgc ccgggccctg gcccgcggag ccggcccggc gaactcggtc      720

taa                                                                    723


<210>  8
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  8

Met Ala Arg Arg Arg His Arg Gly Pro Arg Arg Pro Arg Pro Pro Gly 
1               5                   10                  15      


Pro Thr Gly Ala Val Pro Thr Ala Gln Ser Gln Val Thr Ser Thr Pro 
            20                  25                  30          


Asn Ser Glu Pro Val Val Arg Ser Ala Pro Ala Ala Ala Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Ser Gly Pro Pro Pro Ser Cys Ser Leu Leu Leu Arg Gln 
    50                  55                  60                  


Trp Leu His Val Pro Glu Ser Ala Ser Asp Asp Asp Asp Asp Asp Trp 
65                  70                  75                  80  


Pro Asp Ser Pro Pro Pro Glu Pro Ala Pro Glu Ala Arg Pro Thr Ala 
                85                  90                  95      


Ala Ala Pro Arg Pro Arg Ser Pro Pro Pro Gly Ala Gly Pro Gly Gly 
            100                 105                 110         


Gly Ala Asn Pro Ser Pro Pro Pro Ser Arg Pro Phe Arg Leu Pro Pro 
        115                 120                 125             


Arg Leu Ala Leu Arg Leu Arg Val Thr Ala Glu His Leu Ala Arg Leu 
    130                 135                 140                 


Arg Leu Arg Arg Ala Gly Gly Glu Gly Ala Pro Lys Pro Pro Ala Thr 
145                 150                 155                 160 


Pro Ala Thr Pro Ala Thr Pro Thr Arg Val Arg Phe Ser Pro His Val 
                165                 170                 175     


Arg Val Arg His Leu Val Val Trp Ala Ser Ala Ala Arg Leu Ala Arg 
            180                 185                 190         


Arg Gly Ser Trp Ala Arg Glu Arg Ala Asp Arg Ala Arg Phe Arg Arg 
        195                 200                 205             


Arg Val Ala Glu Ala Glu Ala Val Ile Gly Pro Cys Leu Gly Pro Glu 
    210                 215                 220                 


Ala Arg Ala Arg Ala Leu Ala Arg Gly Ala Gly Pro Ala Asn Ser Val 
225                 230                 235                 240 


<210>  9
<211>  726
<212>  DNA
<213>  Herpes simplex virus type 1

<400>  9
atggcccgcc gccgccgcca tcgcggcccc cgccgccccc ggccgcccgg gcccacgggc       60

gcggtcccaa ccgcacagtc ccaggtaacc tccacgccca actcggaacc cgtggtcagg      120

agcgcgcccg cggccgcccc gccgccgccc cccgccagtg ggcccccgcc ttcttgttcg      180

ctgctgctgc gccagtggct ccacgttccc gagtccgcgt ccgacgacga cgacgacgac      240

tggccggaca gccccccgcc cgagccggcg ccagaggccc ggcccaccgc cgccgccccc      300

cgcccccggt ccccaccgcc cggcgcgggc ccggggggcg gggctaaccc ctcccacccc      360

ccctcacgcc ccttccgcct tccgccgcgc ctcgccctcc gcctgcgcgt caccgcagag      420

cacctggcgc gcctgcgcct gcgacgcgcg ggcggggagg gggcgccgaa gccccccgcg      480

acccccgcga cccccgcgac ccccacgcgg gtgcgcttct cgccccacgt ccgggtgcgc      540

cacctggtgg tctgggcctc ggccgcccgc ctggcgcgcc gcggctcgtg ggcccgcgag      600

cgggccgacc gggctcggtt ccggcgccgg gtggcggagg ccgaggcggt catcgggccg      660

tgcctggggc ccgaggcccg tgcccgggcc ctggcccgcg gagccggccc ggcgaactcg      720

gtctaa                                                                 726


<210>  10
<211>  241
<212>  PRT
<213>  Herpes simplex virus type 1

<400>  10

Met Ala Arg Arg Arg Arg His Arg Gly Pro Arg Arg Pro Arg Pro Pro 
1               5                   10                  15      


Gly Pro Thr Gly Ala Val Pro Thr Ala Gln Ser Gln Val Thr Ser Thr 
            20                  25                  30          


Pro Asn Ser Glu Pro Val Val Arg Ser Ala Pro Ala Ala Ala Pro Pro 
        35                  40                  45              


Pro Pro Pro Ala Ser Gly Pro Pro Pro Ser Cys Ser Leu Leu Leu Arg 
    50                  55                  60                  


Gln Trp Leu His Val Pro Glu Ser Ala Ser Asp Asp Asp Asp Asp Asp 
65                  70                  75                  80  


Trp Pro Asp Ser Pro Pro Pro Glu Pro Ala Pro Glu Ala Arg Pro Thr 
                85                  90                  95      


Ala Ala Ala Pro Arg Pro Arg Ser Pro Pro Pro Gly Ala Gly Pro Gly 
            100                 105                 110         


Gly Gly Ala Asn Pro Ser His Pro Pro Ser Arg Pro Phe Arg Leu Pro 
        115                 120                 125             


Pro Arg Leu Ala Leu Arg Leu Arg Val Thr Ala Glu His Leu Ala Arg 
    130                 135                 140                 


Leu Arg Leu Arg Arg Ala Gly Gly Glu Gly Ala Pro Lys Pro Pro Ala 
145                 150                 155                 160 


Thr Pro Ala Thr Pro Ala Thr Pro Thr Arg Val Arg Phe Ser Pro His 
                165                 170                 175     


Val Arg Val Arg His Leu Val Val Trp Ala Ser Ala Ala Arg Leu Ala 
            180                 185                 190         


Arg Arg Gly Ser Trp Ala Arg Glu Arg Ala Asp Arg Ala Arg Phe Arg 
        195                 200                 205             


Arg Arg Val Ala Glu Ala Glu Ala Val Ile Gly Pro Cys Leu Gly Pro 
    210                 215                 220                 


Glu Ala Arg Ala Arg Ala Leu Ala Arg Gly Ala Gly Pro Ala Asn Ser 
225                 230                 235                 240 


Val 
    


<210>  11
<211>  1971
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  11
aacacattaa ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc       60

aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat      120

cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact      180

catcaatgta tcttatcatg tctgctcgaa gcggccggcc gccccgactc tagactacac      240

attgatccta gcagaagcac aggctgcagg gtgacggtcc atcccgctct cctgggcaca      300

agacatgggc agcgtgccat catcctgctc ctccacctcc ggcgggaagc catggctaag      360

cttcttgtac agctcgtcca tgccgagagt gatcccggcg gcggtcacga actccagcag      420

gaccatgtga tcgcgcttct cgttggggtc tttgctcagg gcggactggg tgctcaggta      480

gtggttgtcg ggcagcagca cggggccgtc gccgatgggg gtgttctgct ggtagtggtc      540

ggcgagctgc acgctgccgt cctcgatgtt gtggcggatc ttgaagttca ccttgatgcc      600

gttcttctgc ttgtcggcca tgatatagac gttgtggctg ttgtagttgt actccagctt      660

gtgccccagg atgttgccgt cctccttgaa gtcgatgccc ttcagctcga tgcggttcac      720

cagggtgtcg ccctcgaact tcacctcggc gcgggtcttg tagttgccgt cgtccttgaa      780

gaagatggtg cgctcctgga cgtagccttc gggcatggcg gacttgaaga agtcgtgctg      840

cttcatgtgg tcggggtagc ggctgaagca ctgcacgccg taggtcaggg tggtcacgag      900

ggtgggccag ggcacgggca gcttgccggt ggtgcagatg aacttcaggg tcagcttgcc      960

gtaggtggca tcgccctcgc cctcgccgga cacgctgaac ttgtggccgt ttacgtcgcc     1020

gtccagctcg accaggatgg gcaccacccc ggtgaacagc tcctcgccct tgctcaccat     1080

ccgggaattg cggccgcggg tacaattccg cagcttttag agcagaagta acacttccgt     1140

acaggcctag aagtaaaggc aacatccact gaggagcagt tctttgattt gcaccaccac     1200

cggatccggg acctgaaata aaagacaaaa agactaaact taccagttaa ctttctggtt     1260

tttcagttcc tcgagtaccg gatcctctag agtccggagg ctggatcggt cccggtgtct     1320

tctatggagg tcaaaacagc gtggatggcg tctccaggcg atctgacggt tcactaaacg     1380

agctctgctt atatagacct cccaccgtac acgcctaccg cccatttgcg tcaatggggc     1440

ggagttgtta cgacattttg gaaagtcccg ttgattttgg tgccaaaaca aactcccatt     1500

gacgtcaatg gggtggagac ttggaaatcc ccgtgagtca aaccgctatc cacgcccatt     1560

gatgtactgc caaaaccgca tcaccatggt aatagcgatg actaatacgt agatgtactg     1620

ccaagtagga aagtcccata aggtcatgta ctgggcataa tgccaggcgg gccatttacc     1680

gtcattgacg tcaatagggg gcgtacttgg catatgatac acttgatgta ctgccaagtg     1740

ggcagtttac cgtaaatact ccacccattg acgtcaatgg aaagtcccta ttggcgttac     1800

tatgggaaca tacgtcatta ttgacgtcaa tgggcggggg tcgttgggcg gtcagccagg     1860

cgggccattt accgtaagtt atgtaacgac ctgcaggcat gcaagctcga attcgaacac     1920

gcagatgcag tcggggcggc agatcttaat taatggctgg ttgtttgttg t              1971


<210>  12
<211>  1653
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  mutation
<222>  (451)..(451)
<223>  g451a

<400>  12
atggatcgcg gggcggtggt ggggtttctt ctcggtgttt gtgttgtatc gtgcttggcg       60

ggaacgccca aaacgtcctg gagacgggtg agtgtcggcg aggacgtttc gttgcttcca      120

gctccggggc ctacggggcg cggcccgacc cagaaactac tatgggccgt ggaacccctg      180

gatgggtgcg gccccttaca cccgtcgtgg gtctcgctga tgccccccaa gcaggtgccc      240

gagacggtcg tggatgcggc gtgcatgcgc gctccggtcc cgctggcgat ggcgtacgcc      300

cccccggccc catctgcgac cgggggtcta cgaacggact tcgtgtggca ggagcgcgcg      360

gccgtggtta accggagtct ggttattcac ggggtccgag agacggacag cggcctgtat      420

accctgtccg tgggcgacat aaaggacccg actcgccaag tggcctcggt ggtcctggtg      480

gtgcaaccgg ccccagttcc gaccccaccc ccgaccccag ccgattacga cgaggatgac      540

aatgacgagg gcgaggacga aagtctcgcc ggcactcccg ccagcgggac cccccggctc      600

ccgcctcccc ccgccccccc gaggtcttgg cccagcgccc ccgaagtctc acatgtgcgt      660

ggggtgaccg tgcgtatgga gactccggaa gctatcctgt tttcccccgg ggagacgttc      720

agcacgaacg tctccatcca tgccatcgcc cacgacgacc agacctactc catggacgtc      780

gtctggttga ggttcgacgt gccgacctcg tgtgccgaga tgcgaatata cgaatcgtgt      840

ctgtatcacc cgcagctccc agaatgtctg tccccggccg acgcgccgtg cgccgcgagt      900

acgtggacgt ctcgcctggc cgtccgcagc tacgcggggt gttccagaac aaacccccca      960

ccgcgctgtt cggccgaggc tcacatggag cccgtcccgg ggctggcgtg gcaggcggcc     1020

tccgtcaatc tggagttccg ggacgcgtcc ccacaacact ccggcctgta tctgtgtgtg     1080

gtgtacgtca acgaccatat tcacgcctgg ggccacatta ccatcagcac cgcggcgcag     1140

taccggaacg cggtggtgga acagcccctc ccacagcgcg gcgcggattt ggccgagccc     1200

acccacccgc acgtcggggc ccctccccac gcgcccccaa cccacggcgc cctgcggtta     1260

ggggcggtga tgggggccgc cctgctgctg tctgcgctgg ggttgtcggt gtgggcgtgt     1320

atgacctgtt ggcgcaggcg tgcctggcgg gcggttaaaa gcagggcctc gggtaagggg     1380

cccacgtaca ttcgcgtggc cgacagcgag ctgtacgcgg actggagctc ggacagcgag     1440

ggagaacgcg accaggtccc gtggctggcc cccccggaga gacccgactc tccctccacc     1500

aatggatccg gctttgagat cttatcacca acggctccgt ctgtataccc ccgtagcgac     1560

gggcatcaat ctcgccgcca gctcacaacc tttggatccg gaaggcccga tcgccgttac     1620

tcccaggcct ccgattcgtc cgtcttctgg taa                                  1653


<210>  13
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (151)..(151)
<223>  A151T

<400>  13

Met Asp Arg Gly Ala Val Val Gly Phe Leu Leu Gly Val Cys Val Val 
1               5                   10                  15      


Ser Cys Leu Ala Gly Thr Pro Lys Thr Ser Trp Arg Arg Val Ser Val 
            20                  25                  30          


Gly Glu Asp Val Ser Leu Leu Pro Ala Pro Gly Pro Thr Gly Arg Gly 
        35                  40                  45              


Pro Thr Gln Lys Leu Leu Trp Ala Val Glu Pro Leu Asp Gly Cys Gly 
    50                  55                  60                  


Pro Leu His Pro Ser Trp Val Ser Leu Met Pro Pro Lys Gln Val Pro 
65                  70                  75                  80  


Glu Thr Val Val Asp Ala Ala Cys Met Arg Ala Pro Val Pro Leu Ala 
                85                  90                  95      


Met Ala Tyr Ala Pro Pro Ala Pro Ser Ala Thr Gly Gly Leu Arg Thr 
            100                 105                 110         


Asp Phe Val Trp Gln Glu Arg Ala Ala Val Val Asn Arg Ser Leu Val 
        115                 120                 125             


Ile His Gly Val Arg Glu Thr Asp Ser Gly Leu Tyr Thr Leu Ser Val 
    130                 135                 140                 


Gly Asp Ile Lys Asp Pro Thr Arg Gln Val Ala Ser Val Val Leu Val 
145                 150                 155                 160 


Val Gln Pro Ala Pro Val Pro Thr Pro Pro Pro Thr Pro Ala Asp Tyr 
                165                 170                 175     


Asp Glu Asp Asp Asn Asp Glu Gly Glu Asp Glu Ser Leu Ala Gly Thr 
            180                 185                 190         


Pro Ala Ser Gly Thr Pro Arg Leu Pro Pro Pro Pro Ala Pro Pro Arg 
        195                 200                 205             


Ser Trp Pro Ser Ala Pro Glu Val Ser His Val Arg Gly Val Thr Val 
    210                 215                 220                 


Arg Met Glu Thr Pro Glu Ala Ile Leu Phe Ser Pro Gly Glu Thr Phe 
225                 230                 235                 240 


Ser Thr Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gln Thr Tyr 
                245                 250                 255     


Ser Met Asp Val Val Trp Leu Arg Phe Asp Val Pro Thr Ser Cys Ala 
            260                 265                 270         


Glu Met Arg Ile Tyr Glu Ser Cys Leu Tyr His Pro Gln Leu Pro Glu 
        275                 280                 285             


Cys Leu Ser Pro Ala Asp Ala Pro Cys Ala Ala Ser Thr Trp Thr Ser 
    290                 295                 300                 


Arg Leu Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Asn Pro Pro 
305                 310                 315                 320 


Pro Arg Cys Ser Ala Glu Ala His Met Glu Pro Val Pro Gly Leu Ala 
                325                 330                 335     


Trp Gln Ala Ala Ser Val Asn Leu Glu Phe Arg Asp Ala Ser Pro Gln 
            340                 345                 350         


His Ser Gly Leu Tyr Leu Cys Val Val Tyr Val Asn Asp His Ile His 
        355                 360                 365             


Ala Trp Gly His Ile Thr Ile Ser Thr Ala Ala Gln Tyr Arg Asn Ala 
    370                 375                 380                 


Val Val Glu Gln Pro Leu Pro Gln Arg Gly Ala Asp Leu Ala Glu Pro 
385                 390                 395                 400 


Thr His Pro His Val Gly Ala Pro Pro His Ala Pro Pro Thr His Gly 
                405                 410                 415     


Ala Leu Arg Leu Gly Ala Val Met Gly Ala Ala Leu Leu Leu Ser Ala 
            420                 425                 430         


Leu Gly Leu Ser Val Trp Ala Cys Met Thr Cys Trp Arg Arg Arg Ala 
        435                 440                 445             


Trp Arg Ala Val Lys Ser Arg Ala Ser Gly Lys Gly Pro Thr Tyr Ile 
    450                 455                 460                 


Arg Val Ala Asp Ser Glu Leu Tyr Ala Asp Trp Ser Ser Asp Ser Glu 
465                 470                 475                 480 


Gly Glu Arg Asp Gln Val Pro Trp Leu Ala Pro Pro Glu Arg Pro Asp 
                485                 490                 495     


Ser Pro Ser Thr Asn Gly Ser Gly Phe Glu Ile Leu Ser Pro Thr Ala 
            500                 505                 510         


Pro Ser Val Tyr Pro Arg Ser Asp Gly His Gln Ser Arg Arg Gln Leu 
        515                 520                 525             


Thr Thr Phe Gly Ser Gly Arg Pro Asp Arg Arg Tyr Ser Gln Ala Ser 
    530                 535                 540                 


Asp Ser Ser Val Phe Trp 
545                 550 


<210>  14
<211>  1653
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  14
atggatcgcg gggcggtggt ggggtttctt ctcggtgttt gtgttgtatc gtgcttggcg       60

ggaacgccca aaacgtcctg gagacgggtg agtgtcggcg aggacgtttc gttgcttcca      120

gctccggggc ctacggggcg cggcccgacc cagaaactac tatgggccgt ggaacccctg      180

gatgggtgcg gccccttaca cccgtcgtgg gtctcgctga tgccccccaa gcaggtgccc      240

gagacggtcg tggatgcggc gtgcatgcgc gctccggtcc cgctggcgat ggcgtacgcc      300

cccccggccc catctgcgac cgggggtcta cgaacggact tcgtgtggca ggagcgcgcg      360

gccgtggtta accggagtct ggttattcac ggggtccgag agacggacag cggcctgtat      420

accctgtccg tgggcgacat aaaggacccg gctcgccaag tggcctcggt ggtcctggtg      480

gtgcaaccgg ccccagttcc gaccccaccc ccgaccccag ccgattacga cgaggatgac      540

aatgacgagg gcgaggacga aagtctcgcc ggcactcccg ccagcgggac cccccggctc      600

ccgcctcccc ccgccccccc gaggtcttgg cccagcgccc ccgaagtctc acatgtgcgt      660

ggggtgaccg tgcgtatgga gactccggaa gctatcctgt tttcccccgg ggagacgttc      720

agcacgaacg tctccatcca tgccatcgcc cacgacgacc agacctactc catggacgtc      780

gtctggttga ggttcgacgt gccgacctcg tgtgccgaga tgcgaatata cgaatcgtgt      840

ctgtatcacc cgcagctccc agaatgtctg tccccggccg acgcgccgtg cgccgcgagt      900

acgtggacgt ctcgcctggc cgtccgcagc tacgcggggt gttccagaac aaacccccca      960

ccgcgctgtt cggccgaggc tcacatggag cccgtcccgg ggctggcgtg gcaggcggcc     1020

tccgtcaatc tggagttccg ggacgcgtcc ccacaacact ccggcctgta tctgtgtgtg     1080

gtgtacgtca acgaccatat tcacgcctgg ggccacatta ccatcagcac cgcggcgcag     1140

taccggaacg cggtggtgga acagcccctc ccacagcgcg gcgcggattt ggccgagccc     1200

acccacccgc acgtcggggc ccctccccac gcgcccccaa cccacggcgc cctgcggtta     1260

ggggcggtga tgggggccgc cctgctgctg tctgcactgg ggttgtcggt gtgggcgtgt     1320

atgacctgtt ggcgcaggcg tgcctggcgg gcggttaaaa gcagggcctc gggtaagggg     1380

cccacgtaca ttcgcgtggc cgacagcgag ctgtacgcgg actggagctc ggacagcgag     1440

ggagaacgcg accaggtccc gtggctggcc cccccggaga gacccgactc tccctccacc     1500

aatggatccg gctttgagat cttatcacca acggctccgt ctgtataccc ccgtagcgat     1560

gggcatcaat ctcgccgcca gctcacaacc tttggatccg gaaggcccga tcgccgttac     1620

tcccaggcct ccgattcgtc cgtcttctgg taa                                  1653


<210>  15
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  15

Met Asp Arg Gly Ala Val Val Gly Phe Leu Leu Gly Val Cys Val Val 
1               5                   10                  15      


Ser Cys Leu Ala Gly Thr Pro Lys Thr Ser Trp Arg Arg Val Ser Val 
            20                  25                  30          


Gly Glu Asp Val Ser Leu Leu Pro Ala Pro Gly Pro Thr Gly Arg Gly 
        35                  40                  45              


Pro Thr Gln Lys Leu Leu Trp Ala Val Glu Pro Leu Asp Gly Cys Gly 
    50                  55                  60                  


Pro Leu His Pro Ser Trp Val Ser Leu Met Pro Pro Lys Gln Val Pro 
65                  70                  75                  80  


Glu Thr Val Val Asp Ala Ala Cys Met Arg Ala Pro Val Pro Leu Ala 
                85                  90                  95      


Met Ala Tyr Ala Pro Pro Ala Pro Ser Ala Thr Gly Gly Leu Arg Thr 
            100                 105                 110         


Asp Phe Val Trp Gln Glu Arg Ala Ala Val Val Asn Arg Ser Leu Val 
        115                 120                 125             


Ile His Gly Val Arg Glu Thr Asp Ser Gly Leu Tyr Thr Leu Ser Val 
    130                 135                 140                 


Gly Asp Ile Lys Asp Pro Ala Arg Gln Val Ala Ser Val Val Leu Val 
145                 150                 155                 160 


Val Gln Pro Ala Pro Val Pro Thr Pro Pro Pro Thr Pro Ala Asp Tyr 
                165                 170                 175     


Asp Glu Asp Asp Asn Asp Glu Gly Glu Asp Glu Ser Leu Ala Gly Thr 
            180                 185                 190         


Pro Ala Ser Gly Thr Pro Arg Leu Pro Pro Pro Pro Ala Pro Pro Arg 
        195                 200                 205             


Ser Trp Pro Ser Ala Pro Glu Val Ser His Val Arg Gly Val Thr Val 
    210                 215                 220                 


Arg Met Glu Thr Pro Glu Ala Ile Leu Phe Ser Pro Gly Glu Thr Phe 
225                 230                 235                 240 


Ser Thr Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gln Thr Tyr 
                245                 250                 255     


Ser Met Asp Val Val Trp Leu Arg Phe Asp Val Pro Thr Ser Cys Ala 
            260                 265                 270         


Glu Met Arg Ile Tyr Glu Ser Cys Leu Tyr His Pro Gln Leu Pro Glu 
        275                 280                 285             


Cys Leu Ser Pro Ala Asp Ala Pro Cys Ala Ala Ser Thr Trp Thr Ser 
    290                 295                 300                 


Arg Leu Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Asn Pro Pro 
305                 310                 315                 320 


Pro Arg Cys Ser Ala Glu Ala His Met Glu Pro Val Pro Gly Leu Ala 
                325                 330                 335     


Trp Gln Ala Ala Ser Val Asn Leu Glu Phe Arg Asp Ala Ser Pro Gln 
            340                 345                 350         


His Ser Gly Leu Tyr Leu Cys Val Val Tyr Val Asn Asp His Ile His 
        355                 360                 365             


Ala Trp Gly His Ile Thr Ile Ser Thr Ala Ala Gln Tyr Arg Asn Ala 
    370                 375                 380                 


Val Val Glu Gln Pro Leu Pro Gln Arg Gly Ala Asp Leu Ala Glu Pro 
385                 390                 395                 400 


Thr His Pro His Val Gly Ala Pro Pro His Ala Pro Pro Thr His Gly 
                405                 410                 415     


Ala Leu Arg Leu Gly Ala Val Met Gly Ala Ala Leu Leu Leu Ser Ala 
            420                 425                 430         


Leu Gly Leu Ser Val Trp Ala Cys Met Thr Cys Trp Arg Arg Arg Ala 
        435                 440                 445             


Trp Arg Ala Val Lys Ser Arg Ala Ser Gly Lys Gly Pro Thr Tyr Ile 
    450                 455                 460                 


Arg Val Ala Asp Ser Glu Leu Tyr Ala Asp Trp Ser Ser Asp Ser Glu 
465                 470                 475                 480 


Gly Glu Arg Asp Gln Val Pro Trp Leu Ala Pro Pro Glu Arg Pro Asp 
                485                 490                 495     


Ser Pro Ser Thr Asn Gly Ser Gly Phe Glu Ile Leu Ser Pro Thr Ala 
            500                 505                 510         


Pro Ser Val Tyr Pro Arg Ser Asp Gly His Gln Ser Arg Arg Gln Leu 
        515                 520                 525             


Thr Thr Phe Gly Ser Gly Arg Pro Asp Arg Arg Tyr Ser Gln Ala Ser 
    530                 535                 540                 


Asp Ser Ser Val Phe Trp 
545                 550 


<210>  16
<211>  1653
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  16
atggatcgcg gggcggtggt ggggtttctt ctcggtgttt gtgttgtatc gtgcttggcg       60

ggaacgccca aaacgtcctg gagacgggtg agtgtcggcg aggacgtttc gttgcttcca      120

gctccggggc ctacggggcg cggcccgacc cagaaactac tatgggccgt ggaacccctg      180

gatgggtgcg gccccttaca cccgtcgtgg gtctcgctga tgccccccaa gcaggtgccc      240

gagacggtcg tggatgcggc gtgcatgcgc gctccggtcc cgctggcgat ggcgtacgcc      300

cccccggccc catctgcgac cgggggtcta cgaacggact tcgtgtggca ggagcgcgcg      360

gccgtggtta accggagtct ggttattcac ggggtccgag agacggacag cggcctgtat      420

accctgtccg tgggcgacat aaaggacccg gctcgccaag tggcctcggt ggtcctggtg      480

gtgcaaccgg ccccagttcc gaccccaccc ccgaccccag ccgattacga cgaggatgac      540

aatgacgagg gcgaggacga aagtctcgcc ggcactcccg ccagcgggac cccccggctc      600

ccgcctcccc ccgccccccc gaggtcttgg cccagcgccc ccgaagtctc acatgtgcgt      660

ggggtgaccg tgcgtatgga gactccggaa gctatcctgt tttcccccgg ggagacgttc      720

agcacgaacg tctccatcca tgccatcgcc cacgacgacc agacctactc catggacgtc      780

gtctggttga ggttcgacgt gccgacctcg tgtgccgaga tgcgaatata cgaatcgtgt      840

ctgtatcacc cgcagctccc agaatgtctg tccccggccg acgcgccgtg cgccgcgagt      900

acgtggacgt ctcgcctggc cgtccgcagc tacgcggggt gttccagaac aaacccccca      960

ccgcgctgtt cggccgaggc tcacatggag cccgtcccgg ggctggcgtg gcaggcggcc     1020

tccgtcaatc tggagttccg ggacgcgtcc ccacaacact ccggcctgta tctgtgtgtg     1080

gtgtacgtca acgaccatat tcacgcctgg ggccacatta ccatcagcac cgcggcgcag     1140

taccggaacg cggtggtgga acagcccctc ccacagcgcg gcgcggattt ggccgagccc     1200

acccacccgc acgtcggggc ccctccccac gcgcccccaa cccacggcgc cctgcggtta     1260

ggggcggtga tgggggccgc cctgctgctg tctgcgctgg ggttgtcggt gtgggcgtgt     1320

atgacctgtt ggcgcaggcg tgcctggcgg gcggttaaaa gcagggcctc gggtaagggg     1380

cccacgtaca ttcgcgtggc cgacagcgag ctgtacgcgg actggagctc ggacagcgag     1440

ggagaacgcg accaggtccc gtggctggcc cccccggaga gacccgactc tccctccacc     1500

aatggatccg gctttgagat cttatcacca acggctccgt ctgtataccc ccgtagcgac     1560

gggcatcaat ctcgccgcca gctcacaacc tttggatccg gaaggcccga tcgccgttac     1620

tcccaggcct ccgattcgtc cgtcttctgg taa                                  1653


<210>  17
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  17

Met Asp Arg Gly Ala Val Val Gly Phe Leu Leu Gly Val Cys Val Val 
1               5                   10                  15      


Ser Cys Leu Ala Gly Thr Pro Lys Thr Ser Trp Arg Arg Val Ser Val 
            20                  25                  30          


Gly Glu Asp Val Ser Leu Leu Pro Ala Pro Gly Pro Thr Gly Arg Gly 
        35                  40                  45              


Pro Thr Gln Lys Leu Leu Trp Ala Val Glu Pro Leu Asp Gly Cys Gly 
    50                  55                  60                  


Pro Leu His Pro Ser Trp Val Ser Leu Met Pro Pro Lys Gln Val Pro 
65                  70                  75                  80  


Glu Thr Val Val Asp Ala Ala Cys Met Arg Ala Pro Val Pro Leu Ala 
                85                  90                  95      


Met Ala Tyr Ala Pro Pro Ala Pro Ser Ala Thr Gly Gly Leu Arg Thr 
            100                 105                 110         


Asp Phe Val Trp Gln Glu Arg Ala Ala Val Val Asn Arg Ser Leu Val 
        115                 120                 125             


Ile His Gly Val Arg Glu Thr Asp Ser Gly Leu Tyr Thr Leu Ser Val 
    130                 135                 140                 


Gly Asp Ile Lys Asp Pro Ala Arg Gln Val Ala Ser Val Val Leu Val 
145                 150                 155                 160 


Val Gln Pro Ala Pro Val Pro Thr Pro Pro Pro Thr Pro Ala Asp Tyr 
                165                 170                 175     


Asp Glu Asp Asp Asn Asp Glu Gly Glu Asp Glu Ser Leu Ala Gly Thr 
            180                 185                 190         


Pro Ala Ser Gly Thr Pro Arg Leu Pro Pro Pro Pro Ala Pro Pro Arg 
        195                 200                 205             


Ser Trp Pro Ser Ala Pro Glu Val Ser His Val Arg Gly Val Thr Val 
    210                 215                 220                 


Arg Met Glu Thr Pro Glu Ala Ile Leu Phe Ser Pro Gly Glu Thr Phe 
225                 230                 235                 240 


Ser Thr Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gln Thr Tyr 
                245                 250                 255     


Ser Met Asp Val Val Trp Leu Arg Phe Asp Val Pro Thr Ser Cys Ala 
            260                 265                 270         


Glu Met Arg Ile Tyr Glu Ser Cys Leu Tyr His Pro Gln Leu Pro Glu 
        275                 280                 285             


Cys Leu Ser Pro Ala Asp Ala Pro Cys Ala Ala Ser Thr Trp Thr Ser 
    290                 295                 300                 


Arg Leu Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Asn Pro Pro 
305                 310                 315                 320 


Pro Arg Cys Ser Ala Glu Ala His Met Glu Pro Val Pro Gly Leu Ala 
                325                 330                 335     


Trp Gln Ala Ala Ser Val Asn Leu Glu Phe Arg Asp Ala Ser Pro Gln 
            340                 345                 350         


His Ser Gly Leu Tyr Leu Cys Val Val Tyr Val Asn Asp His Ile His 
        355                 360                 365             


Ala Trp Gly His Ile Thr Ile Ser Thr Ala Ala Gln Tyr Arg Asn Ala 
    370                 375                 380                 


Val Val Glu Gln Pro Leu Pro Gln Arg Gly Ala Asp Leu Ala Glu Pro 
385                 390                 395                 400 


Thr His Pro His Val Gly Ala Pro Pro His Ala Pro Pro Thr His Gly 
                405                 410                 415     


Ala Leu Arg Leu Gly Ala Val Met Gly Ala Ala Leu Leu Leu Ser Ala 
            420                 425                 430         


Leu Gly Leu Ser Val Trp Ala Cys Met Thr Cys Trp Arg Arg Arg Ala 
        435                 440                 445             


Trp Arg Ala Val Lys Ser Arg Ala Ser Gly Lys Gly Pro Thr Tyr Ile 
    450                 455                 460                 


Arg Val Ala Asp Ser Glu Leu Tyr Ala Asp Trp Ser Ser Asp Ser Glu 
465                 470                 475                 480 


Gly Glu Arg Asp Gln Val Pro Trp Leu Ala Pro Pro Glu Arg Pro Asp 
                485                 490                 495     


Ser Pro Ser Thr Asn Gly Ser Gly Phe Glu Ile Leu Ser Pro Thr Ala 
            500                 505                 510         


Pro Ser Val Tyr Pro Arg Ser Asp Gly His Gln Ser Arg Arg Gln Leu 
        515                 520                 525             


Thr Thr Phe Gly Ser Gly Arg Pro Asp Arg Arg Tyr Ser Gln Ala Ser 
    530                 535                 540                 


Asp Ser Ser Val Phe Trp 
545                 550 


<210>  18
<211>  1653
<212>  DNA
<213>  Herpes simplex virus type 1

<400>  18
atggatcgcg gggcggtggt ggggtttctt ctcggtgttt gtgttgtatc gtgcttggcg       60

ggaacgccca aaacgtcctg gagacgggtg agtgtcggcg aggacgtttc gttgcttcca      120

gctccggggc ctacggggcg cggcccgacc cagaaactac tatgggccgt ggaacccctg      180

gatgggtgcg gccccttaca cccgtcgtgg gtctcgctga tgccccccaa gcaggtgccc      240

gagacggtcg tggatgcggc gtgcatgcgc gctccggtcc cgctggcgat ggcgtacgcc      300

cccccggccc catctgcgac cgggggtcta cgaacggact tcgtgtggca ggagcgcgcg      360

gccgtggtta accggagtct ggttattcac ggggtccgag agacggacag cggcctgtat      420

accctgtccg tgggcgacat aaaggacccg gctcgccaag tggcctcggt ggtcctggtg      480

gtgcaaccgg ccccagttcc gaccccaccc ccgaccccag ccgattacga cgaggatgac      540

aatgacgagg gcgaggacga aagtctcgcc ggcactcccg ccagcgggac cccccggctc      600

ccgcctcccc ccgccccccc gaggtcttgg cccagcgccc ccgaagtctc acatgtgcgt      660

ggggtgaccg tgcgtatgga gactccggaa gctatcctgt tttcccccgg ggagacgttc      720

agcacgaacg tctccatcca tgccatcgcc cacgacgacc agacctactc catggacgtc      780

gtctggttga ggttcgacgt gccgacctcg tgtgccgaga tgcgaatata cgaatcgtgt      840

ctgtatcacc cgcagctccc agaatgtctg tccccggccg acgcgccgtg cgccgcgagt      900

acgtggacgt ctcgcctggc cgtccgcagc tacgcggggt gttccagaac aaacccccca      960

ccgcgctgtt cggccgaggc tcacatggag cccgtcccgg ggctggcgtg gcaggcggcc     1020

tccgtcaatc tggagttccg ggacgcgtcc ccacaacact ccggcctgta tctgtgtgtg     1080

gtgtacgtca acgaccatat tcacgcctgg ggccacatta ccatcagcac cgcggcgcag     1140

taccggaacg cggtggtgga acagcccctc ccacagcgcg gcgcggattt ggccgagccc     1200

acccacccgc acgtcggggc ccctccccac gcgcccccaa cccacggcgc cctgcggtta     1260

ggggcggtga tgggggccgc cctgctgctg tctgcgctgg ggttgtcggt gtgggcgtgt     1320

atgacctgtt ggcgcaggcg tgcctggcgg gcggttaaaa gcagggcctc gggtaagggg     1380

cccacgtaca ttcgcgtggc cgacagcgag ctgtacgcgg actggagctc ggacagcgag     1440

ggagaacgcg accaggtccc gtggctggcc cccccggaga gacccgactc tccctccacc     1500

aatggatccg gctttgagat cttatcacca acggctccgt ctgtataccc ccgtagcgac     1560

gggcatcaat ctcgccgcca gctcacaacc tttggatccg gaaggcccga tcgccgttac     1620

tcccaggcct ccgattcgtc cgtcttctgg taa                                  1653


<210>  19
<211>  550
<212>  PRT
<213>  Herpes simplex virus type 1

<400>  19

Met Asp Arg Gly Ala Val Val Gly Phe Leu Leu Gly Val Cys Val Val 
1               5                   10                  15      


Ser Cys Leu Ala Gly Thr Pro Lys Thr Ser Trp Arg Arg Val Ser Val 
            20                  25                  30          


Gly Glu Asp Val Ser Leu Leu Pro Ala Pro Gly Pro Thr Gly Arg Gly 
        35                  40                  45              


Pro Thr Gln Lys Leu Leu Trp Ala Val Glu Pro Leu Asp Gly Cys Gly 
    50                  55                  60                  


Pro Leu His Pro Ser Trp Val Ser Leu Met Pro Pro Lys Gln Val Pro 
65                  70                  75                  80  


Glu Thr Val Val Asp Ala Ala Cys Met Arg Ala Pro Val Pro Leu Ala 
                85                  90                  95      


Met Ala Tyr Ala Pro Pro Ala Pro Ser Ala Thr Gly Gly Leu Arg Thr 
            100                 105                 110         


Asp Phe Val Trp Gln Glu Arg Ala Ala Val Val Asn Arg Ser Leu Val 
        115                 120                 125             


Ile His Gly Val Arg Glu Thr Asp Ser Gly Leu Tyr Thr Leu Ser Val 
    130                 135                 140                 


Gly Asp Ile Lys Asp Pro Ala Arg Gln Val Ala Ser Val Val Leu Val 
145                 150                 155                 160 


Val Gln Pro Ala Pro Val Pro Thr Pro Pro Pro Thr Pro Ala Asp Tyr 
                165                 170                 175     


Asp Glu Asp Asp Asn Asp Glu Gly Glu Asp Glu Ser Leu Ala Gly Thr 
            180                 185                 190         


Pro Ala Ser Gly Thr Pro Arg Leu Pro Pro Pro Pro Ala Pro Pro Arg 
        195                 200                 205             


Ser Trp Pro Ser Ala Pro Glu Val Ser His Val Arg Gly Val Thr Val 
    210                 215                 220                 


Arg Met Glu Thr Pro Glu Ala Ile Leu Phe Ser Pro Gly Glu Thr Phe 
225                 230                 235                 240 


Ser Thr Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gln Thr Tyr 
                245                 250                 255     


Ser Met Asp Val Val Trp Leu Arg Phe Asp Val Pro Thr Ser Cys Ala 
            260                 265                 270         


Glu Met Arg Ile Tyr Glu Ser Cys Leu Tyr His Pro Gln Leu Pro Glu 
        275                 280                 285             


Cys Leu Ser Pro Ala Asp Ala Pro Cys Ala Ala Ser Thr Trp Thr Ser 
    290                 295                 300                 


Arg Leu Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Asn Pro Pro 
305                 310                 315                 320 


Pro Arg Cys Ser Ala Glu Ala His Met Glu Pro Val Pro Gly Leu Ala 
                325                 330                 335     


Trp Gln Ala Ala Ser Val Asn Leu Glu Phe Arg Asp Ala Ser Pro Gln 
            340                 345                 350         


His Ser Gly Leu Tyr Leu Cys Val Val Tyr Val Asn Asp His Ile His 
        355                 360                 365             


Ala Trp Gly His Ile Thr Ile Ser Thr Ala Ala Gln Tyr Arg Asn Ala 
    370                 375                 380                 


Val Val Glu Gln Pro Leu Pro Gln Arg Gly Ala Asp Leu Ala Glu Pro 
385                 390                 395                 400 


Thr His Pro His Val Gly Ala Pro Pro His Ala Pro Pro Thr His Gly 
                405                 410                 415     


Ala Leu Arg Leu Gly Ala Val Met Gly Ala Ala Leu Leu Leu Ser Ala 
            420                 425                 430         


Leu Gly Leu Ser Val Trp Ala Cys Met Thr Cys Trp Arg Arg Arg Ala 
        435                 440                 445             


Trp Arg Ala Val Lys Ser Arg Ala Ser Gly Lys Gly Pro Thr Tyr Ile 
    450                 455                 460                 


Arg Val Ala Asp Ser Glu Leu Tyr Ala Asp Trp Ser Ser Asp Ser Glu 
465                 470                 475                 480 


Gly Glu Arg Asp Gln Val Pro Trp Leu Ala Pro Pro Glu Arg Pro Asp 
                485                 490                 495     


Ser Pro Ser Thr Asn Gly Ser Gly Phe Glu Ile Leu Ser Pro Thr Ala 
            500                 505                 510         


Pro Ser Val Tyr Pro Arg Ser Asp Gly His Gln Ser Arg Arg Gln Leu 
        515                 520                 525             


Thr Thr Phe Gly Ser Gly Arg Pro Asp Arg Arg Tyr Ser Gln Ala Ser 
    530                 535                 540                 


Asp Ser Ser Val Phe Trp 
545                 550 


<210>  20
<211>  3267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  Intron
<222>  (58)..(861)
<223>  intron

<220>
<221>  mutation
<222>  (848)..(848)
<223>  a848c

<220>
<221>  Intron
<222>  (1529)..(1663)
<223>  intron

<220>
<221>  mutation
<222>  (1712)..(1712)
<223>  g1712a

<400>  20
atggagcccc gccccggagc gagtacccgc cggcctgagg gccgccccca gcgcgaggtg       60

aggggccggg cgccatgtct ggggcgccat gtctggggcg ccatgtctgg ggcgccatgt      120

ctggggcgcc atgttggggg gcgccatgtt ggggggcgcc atgttggggg acccccgacc      180

cttacactgg aaccggccgc catgttgggg gacccccact catacacggg agccgggcgc      240

catgttgggg cgccatgtta gggggcgtgg aaccccgtga cactatatat acagggaccg      300

ggggcgccat gttagggggc gcggaacccc ctgaccctat atatacaggg accggggtcg      360

ccctgttagg ggtcgccatg tgaccccctg actttatata tacagacccc caacacctac      420

acatggcccc tttgactcag acgcagggcc cggggtcgcc gtgggacccc cctgactcat      480

acacagagac acgcccccac aacaaacaca cagggaccgg ggtcgccgtg ttagggggcg      540

tggtccccac tgactcatac gcagggcccc cttactcaca cgcatctagg ggggtgggga      600

ggagccgccc gccatatttg ggggacgccg tgggaccccc gactccggtg cgtctggagg      660

gcgggagaag agggaagaag aggggtcggg atccaaagga cggacccaga ccacctttgg      720

ttgcagaccc ctttctcccc cctcttccga ggccagcagg ggggcaggac tttgtgaggc      780

ggggggggag ggggaactcg tgggcgctga ttgacgcggg aaatcccccc attcttaccc      840

gccccccctt tttcccctca gcccgccccg gatgtctggg tgtttccctg cgaccgagac      900

ctgccggaca gcagcgactc ggaggcggag accgaagtgg gggggcgggg ggacgccgac      960

caccatgacg acgactccgc ctccgaggcg gacagcacgg acacggaact gttcgagacg     1020

gggctgctgg ggccgcaggg cgtggatggg ggggcggtct cgggggggag ccccccccgc     1080

gaggaagacc ccggcagttg cgggggcgcc ccccctcgag aggacggggg gagcgacgag     1140

ggcgacgtgt gcgccgtgtg cacggatgag atcgcgcccc acctgcgctg cgacaccttc     1200

ccgtgcatgc accgcttctg catcccgtgc atgaaaacct ggatgcaatt gcgcaacacc     1260

tgcccgctgt gcaacgccaa gctggtgtac ctgatagtgg gcgtgacgcc cagcgggtcg     1320

ttcagcacca tcccgatcgt gaacgacccc cagacccgca tggaggccga ggaggccgtc     1380

agggcgggca cggccgtgga ctttatctgg acgggcaatc agcggttcgc cccgcggtac     1440

ctgaccctgg gggggcacac ggtgagggcc ctgtcgccca cccacccgga acccaccacg     1500

gacgaggatg acgacgacct ggacgacggt gaggcggggg gcggcaagga ccctggggga     1560

ggaggaggag gagggggggg agggaggaat aggcgggcgg gcgaggaaag ggcgggccgg     1620

ggagggggcg taacctgatc gcgccccccg ttgtctcttg cagcagacta cgtaccgccc     1680

gccccccgcc ggacgccccg cgccccccca cacagaggcg ccgccgcgcc ccccgtgacg     1740

ggcggggcgt ctcacgcagc cccccagccg gccgcggctc ggacagcgcc cccctcggcg     1800

cccatcgggc cacacggcag cagtaacacc aacaccacca ccaacagcag cggcggcggc     1860

ggctcccgcc agtcgcgagc cgcggcgccg cggggggcgt ctggcccctc cgggggggtt     1920

ggggttgggg ttggggttgt tgaagcggag gcggggcggc cgaggggccg gacgggcccc     1980

cttgtcaaca gacccgcccc ccttgcaaac aacagagacc ccatagtgat cagcgactcc     2040

cccccggcct ctccccacag gccccccgcg gcgcccatgc caggctccgc cccccgcccc     2100

gggccccccg cgtccgcggc cgcgtcggga cccgcgcgcc cccgcgcggc cgtggccccg     2160

tgcgtgcgag cgccgcctcc ggggcccggc ccccgcgccc cggcccccgg ggcggagccg     2220

gccgcccgcc ccgcggacgc gcgccgtgtg ccccagtcgc actcgtccct ggctcaggcc     2280

gcgaaccaag aacagagtct gtgccgggcg cgtgcgacgg tggcgcgcgg ctcggggggg     2340

ccgggcgtgg agggtgggca cgggccctcc cgcggcgccg ccccctccgg cgccgccccg     2400

ctcccctccg ccgcctctgt cgagcaggag gcggcggtgc gtccgaggaa gaggcgcggg     2460

tcgggccagg aaaacccctc cccccagtcc acgcgtcccc ccctcgcgcc ggcaggggcc     2520

aagagggcgg cgacgcaccc cccctccgac tcagggccgg gggggcgcgg ccagggtggg     2580

cccgggaccc ccctgacgtc ctcggcggcc tccgcctctt cctcctctgc ctcttcctcc     2640

tcggccccga cccccgcggg ggccgcctct tccgccgccg gggccgcgtc ctcctccgct     2700

tccgcctcct cgggcggggc cgtcggtgcc ctgggaggga gacaagagga aacctccctc     2760

ggcccccgcg ctgcttctgg gccgcggggg ccgaggaagt gtgcccggaa gacgcgccac     2820

gcggagactt ccggggccgt ccccgcgggc ggcctcacgc gctacctgcc catctcgggg     2880

gtctctagcg tggtcgccct gtcgccttac gtgaacaaga cgatcacggg ggactgcctg     2940

cccatcctgg acatggagac ggggaacatc ggggcgtacg tggtcctggt ggaccagacg     3000

ggaaacatgg cgacccggct gcgggccgcg gtccccggct ggagccgccg caccctgctc     3060

cccgagaccg cgggtaacca cgtgatgccc cccgagtacc cgacggcccc cgcgtcggag     3120

tggaacagcc tctggatgac ccccgtgggg aacatgctgt tcgaccaggg caccctagtg     3180

ggcgccctgg acttccgcag cctgcggtct cggcacccgt ggtccgggga gcagggggcg     3240

tcgacccggg acgagggaaa acaataa                                         3267


<210>  21
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (258)..(258)
<223>  R258H

<400>  21

Met Glu Pro Arg Pro Gly Ala Ser Thr Arg Arg Pro Glu Gly Arg Pro 
1               5                   10                  15      


Gln Arg Glu Pro Ala Pro Asp Val Trp Val Phe Pro Cys Asp Arg Asp 
            20                  25                  30          


Leu Pro Asp Ser Ser Asp Ser Glu Ala Glu Thr Glu Val Gly Gly Arg 
        35                  40                  45              


Gly Asp Ala Asp His His Asp Asp Asp Ser Ala Ser Glu Ala Asp Ser 
    50                  55                  60                  


Thr Asp Thr Glu Leu Phe Glu Thr Gly Leu Leu Gly Pro Gln Gly Val 
65                  70                  75                  80  


Asp Gly Gly Ala Val Ser Gly Gly Ser Pro Pro Arg Glu Glu Asp Pro 
                85                  90                  95      


Gly Ser Cys Gly Gly Ala Pro Pro Arg Glu Asp Gly Gly Ser Asp Glu 
            100                 105                 110         


Gly Asp Val Cys Ala Val Cys Thr Asp Glu Ile Ala Pro His Leu Arg 
        115                 120                 125             


Cys Asp Thr Phe Pro Cys Met His Arg Phe Cys Ile Pro Cys Met Lys 
    130                 135                 140                 


Thr Trp Met Gln Leu Arg Asn Thr Cys Pro Leu Cys Asn Ala Lys Leu 
145                 150                 155                 160 


Val Tyr Leu Ile Val Gly Val Thr Pro Ser Gly Ser Phe Ser Thr Ile 
                165                 170                 175     


Pro Ile Val Asn Asp Pro Gln Thr Arg Met Glu Ala Glu Glu Ala Val 
            180                 185                 190         


Arg Ala Gly Thr Ala Val Asp Phe Ile Trp Thr Gly Asn Gln Arg Phe 
        195                 200                 205             


Ala Pro Arg Tyr Leu Thr Leu Gly Gly His Thr Val Arg Ala Leu Ser 
    210                 215                 220                 


Pro Thr His Pro Glu Pro Thr Thr Asp Glu Asp Asp Asp Asp Leu Asp 
225                 230                 235                 240 


Asp Ala Asp Tyr Val Pro Pro Ala Pro Arg Arg Thr Pro Arg Ala Pro 
                245                 250                 255     


Pro His Arg Gly Ala Ala Ala Pro Pro Val Thr Gly Gly Ala Ser His 
            260                 265                 270         


Ala Ala Pro Gln Pro Ala Ala Ala Arg Thr Ala Pro Pro Ser Ala Pro 
        275                 280                 285             


Ile Gly Pro His Gly Ser Ser Asn Thr Asn Thr Thr Thr Asn Ser Ser 
    290                 295                 300                 


Gly Gly Gly Gly Ser Arg Gln Ser Arg Ala Ala Ala Pro Arg Gly Ala 
305                 310                 315                 320 


Ser Gly Pro Ser Gly Gly Val Gly Val Gly Val Gly Val Val Glu Ala 
                325                 330                 335     


Glu Ala Gly Arg Pro Arg Gly Arg Thr Gly Pro Leu Val Asn Arg Pro 
            340                 345                 350         


Ala Pro Leu Ala Asn Asn Arg Asp Pro Ile Val Ile Ser Asp Ser Pro 
        355                 360                 365             


Pro Ala Ser Pro His Arg Pro Pro Ala Ala Pro Met Pro Gly Ser Ala 
    370                 375                 380                 


Pro Arg Pro Gly Pro Pro Ala Ser Ala Ala Ala Ser Gly Pro Ala Arg 
385                 390                 395                 400 


Pro Arg Ala Ala Val Ala Pro Cys Val Arg Ala Pro Pro Pro Gly Pro 
                405                 410                 415     


Gly Pro Arg Ala Pro Ala Pro Gly Ala Glu Pro Ala Ala Arg Pro Ala 
            420                 425                 430         


Asp Ala Arg Arg Val Pro Gln Ser His Ser Ser Leu Ala Gln Ala Ala 
        435                 440                 445             


Asn Gln Glu Gln Ser Leu Cys Arg Ala Arg Ala Thr Val Ala Arg Gly 
    450                 455                 460                 


Ser Gly Gly Pro Gly Val Glu Gly Gly His Gly Pro Ser Arg Gly Ala 
465                 470                 475                 480 


Ala Pro Ser Gly Ala Ala Pro Leu Pro Ser Ala Ala Ser Val Glu Gln 
                485                 490                 495     


Glu Ala Ala Val Arg Pro Arg Lys Arg Arg Gly Ser Gly Gln Glu Asn 
            500                 505                 510         


Pro Ser Pro Gln Ser Thr Arg Pro Pro Leu Ala Pro Ala Gly Ala Lys 
        515                 520                 525             


Arg Ala Ala Thr His Pro Pro Ser Asp Ser Gly Pro Gly Gly Arg Gly 
    530                 535                 540                 


Gln Gly Gly Pro Gly Thr Pro Leu Thr Ser Ser Ala Ala Ser Ala Ser 
545                 550                 555                 560 


Ser Ser Ser Ala Ser Ser Ser Ser Ala Pro Thr Pro Ala Gly Ala Ala 
                565                 570                 575     


Ser Ser Ala Ala Gly Ala Ala Ser Ser Ser Ala Ser Ala Ser Ser Gly 
            580                 585                 590         


Gly Ala Val Gly Ala Leu Gly Gly Arg Gln Glu Glu Thr Ser Leu Gly 
        595                 600                 605             


Pro Arg Ala Ala Ser Gly Pro Arg Gly Pro Arg Lys Cys Ala Arg Lys 
    610                 615                 620                 


Thr Arg His Ala Glu Thr Ser Gly Ala Val Pro Ala Gly Gly Leu Thr 
625                 630                 635                 640 


Arg Tyr Leu Pro Ile Ser Gly Val Ser Ser Val Val Ala Leu Ser Pro 
                645                 650                 655     


Tyr Val Asn Lys Thr Ile Thr Gly Asp Cys Leu Pro Ile Leu Asp Met 
            660                 665                 670         


Glu Thr Gly Asn Ile Gly Ala Tyr Val Val Leu Val Asp Gln Thr Gly 
        675                 680                 685             


Asn Met Ala Thr Arg Leu Arg Ala Ala Val Pro Gly Trp Ser Arg Arg 
    690                 695                 700                 


Thr Leu Leu Pro Glu Thr Ala Gly Asn His Val Met Pro Pro Glu Tyr 
705                 710                 715                 720 


Pro Thr Ala Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro Val 
                725                 730                 735     


Gly Asn Met Leu Phe Asp Gln Gly Thr Leu Val Gly Ala Leu Asp Phe 
            740                 745                 750         


Arg Ser Leu Arg Ser Arg His Pro Trp Ser Gly Glu Gln Gly Ala Ser 
        755                 760                 765             


Thr Arg Asp Glu Gly Lys Gln 
    770                 775 


<210>  22
<211>  3229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  Intron
<222>  (58)..(822)
<223>  intron

<220>
<221>  Intron
<222>  (1490)..(1625)
<223>  intron

<400>  22
atggagcccc gccccggagc gagtacccgc cggcctgagg gccgccccca gcgcgaggtg       60

aggggccggg cgccatgtct ggggcgccat attggggggc gccatattgg ggggcgccat      120

gttgggggac ccccgaccct tacactggaa ccggccgcca tgttggggga cccccactca      180

tacacgggag ccgggcgcca tgttggggcg ccatgttagg gggcgtggaa ccccgtgaca      240

ctatatatac agggaccggg ggcgccatgt tagggggtgc ggaaccccct gaccctatat      300

atacagggac cggggtcgcc ctgttggggg tcgccatgtg accccctgac tttatatata      360

cagaccccca acacatacac atggcccctt tgactcagac gcagggcccg gggtcgccgt      420

gggaccccct gactcataca cagagacacg cccccacaac aaacacacag ggaccggggt      480

cgccgtgttg ggggcgtggt ccccactgac tcatacgcag gcccccctta ctcacacgca      540

tctagggggg tggggaggag ccgcccgcca tatttggggg acgccgtggg acccccgact      600

ccggtgcgtc tggagggcgg gagaagaggg aagaagaggg gtcgggatcc aaaggacgga      660

cccagaccac ctttggttgc agaccccttt ctcccccctc ttccgaggcc agcagggggg      720

caggactttg tgaggcgggg gggggagagg gggaactcgt gggtgctgat tgacgcggga      780

aatccccccc cattcttacc cgcccccctt ttttcccctt agcccgcccc ggatgtctgg      840

gtgtttccct gcgaccgaga cctgccggac agcagcgact ctgaggcgga gaccgaagtg      900

ggggggcggg gggacgccga ccaccatgac gacgactccg cctccgaggc ggacagcacg      960

gacacggaac tgttcgagac ggggctgctg gggccgcagg gcgtggatgg gggggcggtc     1020

tcggggggga gccccccccg cgaggaagac cccggcagtt gcgggggcgc cccccctcga     1080

gaggacgggg ggagcgacga gggtgacgtg tgcgccgtgt gcacggatga gatcgcgccc     1140

cacctgcgct gcgacacctt cccgtgcatg caccgcttct gcatcccgtg catgaaaacc     1200

tggatgcaat tgcgcaacac ctgcccgctg tgcaacgcca agctggtgta cctgatagtg     1260

ggcgtgacgc ccagcgggtc gttcagcacc atcccgatcg tgaacgaccc ccagacccgc     1320

atggaggccg aggaggccgt cagggcgggc acggccgtgg actttatctg gacgggcaat     1380

cagcggttcg ccccgcggta cctgaccctg ggggggcaca cggtgagggc cctgtcgccc     1440

acccacccgg aacccaccac ggacgaggat gacgacgacc tggacgacgg tgaggcgggg     1500

ggcggcaagg accctggggg aggaggagga ggaggggggg ggagggagga ataggcgggc     1560

gggcgaggaa agggcgggcc ggggaggggg cgtaacctga tcgcgccccc cgttgtctct     1620

tgcagcagac tacgtaccgc ccgccccccg ccggacgccc cgcgcccccc cacgcagagg     1680

cgccgccgcg ccccccgtga cgggcggggc gtctcacgca gccccccagc cggccgcggc     1740

tcggacagcg cccccctcgg cgcccatcgg gccacacggc agcagtaaca ccaacaccac     1800

caccaacagc agcggcggcg gcggctcccg ccagtcgcga gccgcggcgc cgcggggggc     1860

gtctggcccc tccggggggg ttggggttgg ggttggggtt gttgaagcgg aggcggggcg     1920

gccgaggggc cggacgggcc cccttgtcaa cagacccgcc ccccttgcaa acaacagaga     1980

ccccatagtg atcagcgact cccccccggc ctctccccac aggccccccg cggcgcccat     2040

gccaggctcc gccccccgcc ccgggccccc cgcgtccgcg gccgcgtcgg gacccgcgcg     2100

cccccgcgcg gccgtggccc cgtgcgtgcg agcgccgcct ccggggcccg gcccccgcgc     2160

cccggccccc ggggcggagc cggccgcccg ccccgcggac gcgcgccgtg tgccccagtc     2220

gcactcgtcc ctggctcagg ccgcgaacca agaacagagt ctgtgccggg cgcgtgcgac     2280

ggtggcgcgc ggctcggggg ggccgggcgt ggagggtggg cacgggccct cccgcggcgc     2340

cgccccctcc ggcgccgccc cgctcccctc cgccgcctct gtcgagcagg aggcggcggt     2400

gcgtccgagg aagaggcgcg ggtcgggcca ggaaaacccc tccccccagt ccacgcgtcc     2460

ccccctcgcg ccggcagggg ccaagagggc ggcgacgcac cccccctccg actcagggcc     2520

gggggggcgc ggccagggtg ggcccgggac ccccctgacg tcctcggcgg cctccgcctc     2580

ttcctcctct gcctcttcct cctcggcccc gacccccgcg ggggccgcct cttccgccgc     2640

cggggccgcg tcctcctccg cttccgcctc ctcgggcggg gccgtcggtg ccctgggagg     2700

gagacaagag gaaacctccc tcggcccccg cgctgcttct gggccgcggg ggccgaggaa     2760

gtgtgcccgg aagacgcgcc acgcggagac ttccggggcc gtccccgcgg gcggcctcac     2820

gcgctacctg cccatctcgg gggtctctag cgtggtcgcc ctgtcgcctt acgtgaacaa     2880

gactatcacg ggggactgcc tgcccatcct ggacatggag acggggaaca tcggggcgta     2940

cgtggtcctg gtggaccaga cgggaaacat ggcgacccgg ctgcgggccg cggtccccgg     3000

ctggagccgc cgcaccctgc tccccgagac cgcgggtaac cacgtgatgc cccccgagta     3060

cccgacggcc cccgcgtcgg agtggaacag cctctggatg acccccgtgg ggaacatgct     3120

gttcgaccag ggcaccctag tgggcgccct ggacttccgc agcctgcggt ctcggcaccc     3180

gtggtccggg gagcaggggg cgtcgacccg ggacgaggga aaacaataa                 3229


<210>  23
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  23

Met Glu Pro Arg Pro Gly Ala Ser Thr Arg Arg Pro Glu Gly Arg Pro 
1               5                   10                  15      


Gln Arg Glu Pro Ala Pro Asp Val Trp Val Phe Pro Cys Asp Arg Asp 
            20                  25                  30          


Leu Pro Asp Ser Ser Asp Ser Glu Ala Glu Thr Glu Val Gly Gly Arg 
        35                  40                  45              


Gly Asp Ala Asp His His Asp Asp Asp Ser Ala Ser Glu Ala Asp Ser 
    50                  55                  60                  


Thr Asp Thr Glu Leu Phe Glu Thr Gly Leu Leu Gly Pro Gln Gly Val 
65                  70                  75                  80  


Asp Gly Gly Ala Val Ser Gly Gly Ser Pro Pro Arg Glu Glu Asp Pro 
                85                  90                  95      


Gly Ser Cys Gly Gly Ala Pro Pro Arg Glu Asp Gly Gly Ser Asp Glu 
            100                 105                 110         


Gly Asp Val Cys Ala Val Cys Thr Asp Glu Ile Ala Pro His Leu Arg 
        115                 120                 125             


Cys Asp Thr Phe Pro Cys Met His Arg Phe Cys Ile Pro Cys Met Lys 
    130                 135                 140                 


Thr Trp Met Gln Leu Arg Asn Thr Cys Pro Leu Cys Asn Ala Lys Leu 
145                 150                 155                 160 


Val Tyr Leu Ile Val Gly Val Thr Pro Ser Gly Ser Phe Ser Thr Ile 
                165                 170                 175     


Pro Ile Val Asn Asp Pro Gln Thr Arg Met Glu Ala Glu Glu Ala Val 
            180                 185                 190         


Arg Ala Gly Thr Ala Val Asp Phe Ile Trp Thr Gly Asn Gln Arg Phe 
        195                 200                 205             


Ala Pro Arg Tyr Leu Thr Leu Gly Gly His Thr Val Arg Ala Leu Ser 
    210                 215                 220                 


Pro Thr His Pro Glu Pro Thr Thr Asp Glu Asp Asp Asp Asp Leu Asp 
225                 230                 235                 240 


Asp Ala Asp Tyr Val Pro Pro Ala Pro Arg Arg Thr Pro Arg Ala Pro 
                245                 250                 255     


Pro Arg Arg Gly Ala Ala Ala Pro Pro Val Thr Gly Gly Ala Ser His 
            260                 265                 270         


Ala Ala Pro Gln Pro Ala Ala Ala Arg Thr Ala Pro Pro Ser Ala Pro 
        275                 280                 285             


Ile Gly Pro His Gly Ser Ser Asn Thr Asn Thr Thr Thr Asn Ser Ser 
    290                 295                 300                 


Gly Gly Gly Gly Ser Arg Gln Ser Arg Ala Ala Ala Pro Arg Gly Ala 
305                 310                 315                 320 


Ser Gly Pro Ser Gly Gly Val Gly Val Gly Val Gly Val Val Glu Ala 
                325                 330                 335     


Glu Ala Gly Arg Pro Arg Gly Arg Thr Gly Pro Leu Val Asn Arg Pro 
            340                 345                 350         


Ala Pro Leu Ala Asn Asn Arg Asp Pro Ile Val Ile Ser Asp Ser Pro 
        355                 360                 365             


Pro Ala Ser Pro His Arg Pro Pro Ala Ala Pro Met Pro Gly Ser Ala 
    370                 375                 380                 


Pro Arg Pro Gly Pro Pro Ala Ser Ala Ala Ala Ser Gly Pro Ala Arg 
385                 390                 395                 400 


Pro Arg Ala Ala Val Ala Pro Cys Val Arg Ala Pro Pro Pro Gly Pro 
                405                 410                 415     


Gly Pro Arg Ala Pro Ala Pro Gly Ala Glu Pro Ala Ala Arg Pro Ala 
            420                 425                 430         


Asp Ala Arg Arg Val Pro Gln Ser His Ser Ser Leu Ala Gln Ala Ala 
        435                 440                 445             


Asn Gln Glu Gln Ser Leu Cys Arg Ala Arg Ala Thr Val Ala Arg Gly 
    450                 455                 460                 


Ser Gly Gly Pro Gly Val Glu Gly Gly His Gly Pro Ser Arg Gly Ala 
465                 470                 475                 480 


Ala Pro Ser Gly Ala Ala Pro Leu Pro Ser Ala Ala Ser Val Glu Gln 
                485                 490                 495     


Glu Ala Ala Val Arg Pro Arg Lys Arg Arg Gly Ser Gly Gln Glu Asn 
            500                 505                 510         


Pro Ser Pro Gln Ser Thr Arg Pro Pro Leu Ala Pro Ala Gly Ala Lys 
        515                 520                 525             


Arg Ala Ala Thr His Pro Pro Ser Asp Ser Gly Pro Gly Gly Arg Gly 
    530                 535                 540                 


Gln Gly Gly Pro Gly Thr Pro Leu Thr Ser Ser Ala Ala Ser Ala Ser 
545                 550                 555                 560 


Ser Ser Ser Ala Ser Ser Ser Ser Ala Pro Thr Pro Ala Gly Ala Ala 
                565                 570                 575     


Ser Ser Ala Ala Gly Ala Ala Ser Ser Ser Ala Ser Ala Ser Ser Gly 
            580                 585                 590         


Gly Ala Val Gly Ala Leu Gly Gly Arg Gln Glu Glu Thr Ser Leu Gly 
        595                 600                 605             


Pro Arg Ala Ala Ser Gly Pro Arg Gly Pro Arg Lys Cys Ala Arg Lys 
    610                 615                 620                 


Thr Arg His Ala Glu Thr Ser Gly Ala Val Pro Ala Gly Gly Leu Thr 
625                 630                 635                 640 


Arg Tyr Leu Pro Ile Ser Gly Val Ser Ser Val Val Ala Leu Ser Pro 
                645                 650                 655     


Tyr Val Asn Lys Thr Ile Thr Gly Asp Cys Leu Pro Ile Leu Asp Met 
            660                 665                 670         


Glu Thr Gly Asn Ile Gly Ala Tyr Val Val Leu Val Asp Gln Thr Gly 
        675                 680                 685             


Asn Met Ala Thr Arg Leu Arg Ala Ala Val Pro Gly Trp Ser Arg Arg 
    690                 695                 700                 


Thr Leu Leu Pro Glu Thr Ala Gly Asn His Val Met Pro Pro Glu Tyr 
705                 710                 715                 720 


Pro Thr Ala Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro Val 
                725                 730                 735     


Gly Asn Met Leu Phe Asp Gln Gly Thr Leu Val Gly Ala Leu Asp Phe 
            740                 745                 750         


Arg Ser Leu Arg Ser Arg His Pro Trp Ser Gly Glu Gln Gly Ala Ser 
        755                 760                 765             


Thr Arg Asp Glu Gly Lys Gln 
    770                 775 


<210>  24
<211>  3275
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  Intron
<222>  (58)..(862)
<223>  intron

<220>
<221>  Intron
<222>  (1530)..(1668)
<223>  intron

<400>  24
atggagcccc gccccggagc gagtacccgc cggcctgagg gccgccccca gcgcgaggtg       60

aggggccggg cgccatgtct ggggcgccat gtctggggcg ccatgtctgg ggcgccatgt      120

ctggggcgcc atgttggggg gcgccatgtt ggggggcgcc atgttggggg acccccgacc      180

cttacactgg aaccggccgc catgttgggg gacccccact catacacggg agccgggcgc      240

catgttgggg cgccatgtta gggggcgtgg aaccccgtga cactatatat acagggaccg      300

ggggcgccat gttagggggc gcggaacccc ctgaccctat atatacaggg accggggtcg      360

ccctgttagg ggtcgccatg tgaccccctg actttatata tacagacccc caacacctac      420

acatggcccc tttgactcag acgcagggcc cggggtcgcc gtgggacccc cctgactcat      480

acacagagac acgcccccac aacaaacaca cagggaccgg ggtcgccgtg ttagggggcg      540

tggtccccac tgactcatac gcagggcccc cttactcaca cgcatctagg ggggtgggga      600

ggagccgccc gccatatttg ggggacgccg tgggaccccc gactccggtg cgtctggagg      660

gcgggagaag agggaagaag aggggtcggg atccaaagga cggacccaga ccacctttgg      720

ttgcagaccc ctttctcccc cctcttccga ggccagcagg ggggcaggac tttgtgaggc      780

ggggggggag ggggaactcg tgggcgctga ttgacgcggg aaatcccccc attcttaccc      840

gccccccctt ttttcccctc agcccgcccc ggatgtctgg gtgtttccct gcgaccgaga      900

cctgccggac agcagcgact cggaggcgga gaccgaagtg ggggggcggg gggacgccga      960

ccaccatgac gacgactccg cctccgaggc ggacagcacg gacacggaac tgttcgagac     1020

ggggctgctg gggccgcagg gcgtggatgg gggggcggtc tcggggggga gccccccccg     1080

cgaggaagac cccggcagtt gcgggggcgc cccccctcga gaggacgggg ggagcgacga     1140

gggcgacgtg tgcgccgtgt gcacggatga gatcgcgccc cacctgcgct gcgacacctt     1200

cccgtgcatg caccgcttct gcatcccgtg catgaaaacc tggatgcaat tgcgcaacac     1260

ctgcccgctg tgcaacgcca agctggtgta cctgatagtg ggcgtgacgc ccagcgggtc     1320

gttcagcacc atcccgatcg tgaacgaccc ccagacccgc atggaggccg aggaggccgt     1380

cagggcgggc acggccgtgg actttatctg gacgggcaat cagcggttcg ccccgcggta     1440

cctgaccctg ggggggcaca cggtgagggc cctgtcgccc acccaccctg agcccaccac     1500

ggacgaggat gacgacgacc tggacgacgg tgaggcgggg gggcggcgag gaccctgggg     1560

gaggaggagg aggggggggg gggggaggaa taggcgggcg ggcgggcgag gaaagggcgg     1620

gccggggagg gggcgtaacc tgatcgcgcc ccccgttgtc tcttgcagca gactacgtac     1680

cgcccgcccc ccgccggacg ccccgcgccc ccccacgcag aggcgccgcc gcgccccccg     1740

tgacgggcgg ggcgtctcac gcagcccccc agccggccgc ggctcggaca gcgcccccct     1800

cggcgcccat cgggccacac ggcagcagta acactaacac caccaccaac agcagcggcg     1860

gcggcggctc ccgccagtcg cgagccgcgg tgccgcgggg ggcgtctggc ccctccgggg     1920

gggttggggt tgttgaagcg gaggcggggc ggccgagggg ccggacgggc ccccttgtca     1980

acagacccgc cccccttgca aacaacagag accccatagt gatcagcgac tcccccccgg     2040

cctctcccca caggcccccc gcggcgccca tgccaggctc cgccccccgc cccggtcccc     2100

ccgcgtccgc ggccgcgtcg ggccccgcgc gcccccgcgc ggccgtggcc ccgtgtgtgc     2160

gggcgccgcc tccggggccc ggcccccgcg ccccggcccc cggggcggag ccggccgccc     2220

gccccgcgga cgcgcgccgt gtgccccagt cgcactcgtc cctggctcag gccgcgaacc     2280

aagaacagag tctgtgccgg gcgcgtgcga cggtggcgcg cggctcgggg gggccgggcg     2340

tggagggtgg acacgggccc tcccgcggcg ccgccccctc cggcgccgcc ccctccggcg     2400

cccccccgct cccctccgcc gcctctgtcg agcaggaggc ggcggtgcgt ccgaggaaga     2460

ggcgcgggtc gggccaggaa aacccctccc cccagtccac gcgtcccccc ctcgcgccgg     2520

caggggccaa gagggcggcg acgcaccccc cctccgactc agggccgggg gggcgcggcc     2580

agggagggcc cgggaccccc ctgacgtcct cggcggcctc cgcctcttcc tcctccgcct     2640

cttcctcctc ggccccgact cccgcggggg ccacctcttc cgccaccggg gccgcgtcct     2700

cctccgcttc cgcctcctcg ggcggggccg tcggtgccct gggagggaga caagaggaaa     2760

cctccctcgg cccccgcgct gcttctgggc cgcgggggcc gaggaagtgt gcccggaaga     2820

cgcgccacgc ggagacttcc ggggccgtcc ccgcgggcgg cctcacgcgc tacctgccca     2880

tctcgggggt ctctagcgtg gtcgccctgt cgccttacgt gaacaagacg atcacggggg     2940

actgcctgcc catcctggac atggagacgg ggaacatcgg ggcgtacgtg gtcctggtgg     3000

accagacggg aaacatggcg acccggctgc gggccgcggt ccccggctgg agccgccgca     3060

ccctgctccc cgagaccgcg ggtaaccacg tgacgccccc cgagtacccg acggcccccg     3120

cgtcggagtg gaacagcctc tggatgaccc ccgtggggaa catgctgttc gaccagggca     3180

ccctagtggg cgccctggac ttccgcagcc tgcggtctcg gcacccgtgg tccggggagc     3240

agggggcgtc gacccgggac gagggaaaac aataa                                3275


<210>  25
<211>  3267
<212>  DNA
<213>  Herpes simplex virus type 1


<220>
<221>  Intron
<222>  (58)..(861)
<223>  intron

<220>
<221>  Intron
<222>  (1529)..(1663)
<223>  intron

<400>  25
atggagcccc gccccggagc gagtacccgc cggcctgagg gccgccccca gcgcgaggtg       60

aggggccggg cgccatgtct ggggcgccat gtctggggcg ccatgtctgg ggcgccatgt      120

ctggggcgcc atgttggggg gcgccatgtt ggggggcgcc atgttggggg acccccgacc      180

cttacactgg aaccggccgc catgttgggg gacccccact catacacggg agccgggcgc      240

catgttgggg cgccatgtta gggggcgtgg aaccccgtga cactatatat acagggaccg      300

ggggcgccat gttagggggc gcggaacccc ctgaccctat atatacaggg accggggtcg      360

ccctgttagg ggtcgccatg tgaccccctg actttatata tacagacccc caacacctac      420

acatggcccc tttgactcag acgcagggcc cggggtcgcc gtgggacccc cctgactcat      480

acacagagac acgcccccac aacaaacaca cagggaccgg ggtcgccgtg ttagggggcg      540

tggtccccac tgactcatac gcagggcccc cttactcaca cgcatctagg ggggtgggga      600

ggagccgccc gccatatttg ggggacgccg tgggaccccc gactccggtg cgtctggagg      660

gcgggagaag agggaagaag aggggtcggg atccaaagga cggacccaga ccacctttgg      720

ttgcagaccc ctttctcccc cctcttccga ggccagcagg ggggcaggac tttgtgaggc      780

ggggggggag ggggaactcg tgggcgctga ttgacgcggg aaatcccccc attcttaccc      840

gccccccttt tttcccctca gcccgccccg gatgtctggg tgtttccctg cgaccgagac      900

ctgccggaca gcagcgactc ggaggcggag accgaagtgg gggggcgggg ggacgccgac      960

caccatgacg acgactccgc ctccgaggcg gacagcacgg acacggaact gttcgagacg     1020

gggctgctgg ggccgcaggg cgtggatggg ggggcggtct cgggggggag ccccccccgc     1080

gaggaagacc ccggcagttg cgggggcgcc ccccctcgag aggacggggg gagcgacgag     1140

ggcgacgtgt gcgccgtgtg cacggatgag atcgcgcccc acctgcgctg cgacaccttc     1200

ccgtgcatgc accgcttctg catcccgtgc atgaaaacct ggatgcaatt gcgcaacacc     1260

tgcccgctgt gcaacgccaa gctggtgtac ctgatagtgg gcgtgacgcc cagcgggtcg     1320

ttcagcacca tcccgatcgt gaacgacccc cagacccgca tggaggccga ggaggccgtc     1380

agggcgggca cggccgtgga ctttatctgg acgggcaatc agcggttcgc cccgcggtac     1440

ctgaccctgg gggggcacac ggtgagggcc ctgtcgccca cccacccgga acccaccacg     1500

gacgaggatg acgacgacct ggacgacggt gaggcggggg gcggcaagga ccctggggga     1560

ggaggaggag gagggggggg agggaggaat aggcgggcgg gcgaggaaag ggcgggccgg     1620

ggagggggcg taacctgatc gcgccccccg ttgtctcttg cagcagacta cgtaccgccc     1680

gccccccgcc ggacgccccg cgccccccca cgcagaggcg ccgccgcgcc ccccgtgacg     1740

ggcggggcgt ctcacgcagc cccccagccg gccgcggctc ggacagcgcc cccctcggcg     1800

cccatcgggc cacacggcag cagtaacacc aacaccacca ccaacagcag cggcggcggc     1860

ggctcccgcc agtcgcgagc cgcggcgccg cggggggcgt ctggcccctc cgggggggtt     1920

ggggttgggg ttggggttgt tgaagcggag gcggggcggc cgaggggccg gacgggcccc     1980

cttgtcaaca gacccgcccc ccttgcaaac aacagagacc ccatagtgat cagcgactcc     2040

cccccggcct ctccccacag gccccccgcg gcgcccatgc caggctccgc cccccgcccc     2100

gggccccccg cgtccgcggc cgcgtcggga cccgcgcgcc cccgcgcggc cgtggccccg     2160

tgcgtgcgag cgccgcctcc ggggcccggc ccccgcgccc cggcccccgg ggcggagccg     2220

gccgcccgcc ccgcggacgc gcgccgtgtg ccccagtcgc actcgtccct ggctcaggcc     2280

gcgaaccaag aacagagtct gtgccgggcg cgtgcgacgg tggcgcgcgg ctcggggggg     2340

ccgggcgtgg agggtgggca cgggccctcc cgcggcgccg ccccctccgg cgccgccccg     2400

ctcccctccg ccgcctctgt cgagcaggag gcggcggtgc gtccgaggaa gaggcgcggg     2460

tcgggccagg aaaacccctc cccccagtcc acgcgtcccc ccctcgcgcc ggcaggggcc     2520

aagagggcgg cgacgcaccc cccctccgac tcagggccgg gggggcgcgg ccagggtggg     2580

cccgggaccc ccctgacgtc ctcggcggcc tccgcctctt cctcctctgc ctcttcctcc     2640

tcggccccga cccccgcggg ggccgcctct tccgccgccg gggccgcgtc ctcctccgct     2700

tccgcctcct cgggcggggc cgtcggtgcc ctgggaggga gacaagagga aacctccctc     2760

ggcccccgcg ctgcttctgg gccgcggggg ccgaggaagt gtgcccggaa gacgcgccac     2820

gcggagactt ccggggccgt ccccgcgggc ggcctcacgc gctacctgcc catctcgggg     2880

gtctctagcg tggtcgccct gtcgccttac gtgaacaaga cgatcacggg ggactgcctg     2940

cccatcctgg acatggagac ggggaacatc ggggcgtacg tggtcctggt ggaccagacg     3000

ggaaacatgg cgacccggct gcgggccgcg gtccccggct ggagccgccg caccctgctc     3060

cccgagaccg cgggtaacca cgtgatgccc cccgagtacc cgacggcccc cgcgtcggag     3120

tggaacagcc tctggatgac ccccgtgggg aacatgctgt tcgaccaggg caccctagtg     3180

ggcgccctgg acttccgcag cctgcggtct cggcacccgt ggtccgggga gcagggggcg     3240

tcgacccggg acgagggaaa acaataa                                         3267


<210>  26
<211>  775
<212>  PRT
<213>  Herpes simplex virus type 1

<400>  26

Met Glu Pro Arg Pro Gly Ala Ser Thr Arg Arg Pro Glu Gly Arg Pro 
1               5                   10                  15      


Gln Arg Glu Pro Ala Pro Asp Val Trp Val Phe Pro Cys Asp Arg Asp 
            20                  25                  30          


Leu Pro Asp Ser Ser Asp Ser Glu Ala Glu Thr Glu Val Gly Gly Arg 
        35                  40                  45              


Gly Asp Ala Asp His His Asp Asp Asp Ser Ala Ser Glu Ala Asp Ser 
    50                  55                  60                  


Thr Asp Thr Glu Leu Phe Glu Thr Gly Leu Leu Gly Pro Gln Gly Val 
65                  70                  75                  80  


Asp Gly Gly Ala Val Ser Gly Gly Ser Pro Pro Arg Glu Glu Asp Pro 
                85                  90                  95      


Gly Ser Cys Gly Gly Ala Pro Pro Arg Glu Asp Gly Gly Ser Asp Glu 
            100                 105                 110         


Gly Asp Val Cys Ala Val Cys Thr Asp Glu Ile Ala Pro His Leu Arg 
        115                 120                 125             


Cys Asp Thr Phe Pro Cys Met His Arg Phe Cys Ile Pro Cys Met Lys 
    130                 135                 140                 


Thr Trp Met Gln Leu Arg Asn Thr Cys Pro Leu Cys Asn Ala Lys Leu 
145                 150                 155                 160 


Val Tyr Leu Ile Val Gly Val Thr Pro Ser Gly Ser Phe Ser Thr Ile 
                165                 170                 175     


Pro Ile Val Asn Asp Pro Gln Thr Arg Met Glu Ala Glu Glu Ala Val 
            180                 185                 190         


Arg Ala Gly Thr Ala Val Asp Phe Ile Trp Thr Gly Asn Gln Arg Phe 
        195                 200                 205             


Ala Pro Arg Tyr Leu Thr Leu Gly Gly His Thr Val Arg Ala Leu Ser 
    210                 215                 220                 


Pro Thr His Pro Glu Pro Thr Thr Asp Glu Asp Asp Asp Asp Leu Asp 
225                 230                 235                 240 


Asp Ala Asp Tyr Val Pro Pro Ala Pro Arg Arg Thr Pro Arg Ala Pro 
                245                 250                 255     


Pro Arg Arg Gly Ala Ala Ala Pro Pro Val Thr Gly Gly Ala Ser His 
            260                 265                 270         


Ala Ala Pro Gln Pro Ala Ala Ala Arg Thr Ala Pro Pro Ser Ala Pro 
        275                 280                 285             


Ile Gly Pro His Gly Ser Ser Asn Thr Asn Thr Thr Thr Asn Ser Ser 
    290                 295                 300                 


Gly Gly Gly Gly Ser Arg Gln Ser Arg Ala Ala Ala Pro Arg Gly Ala 
305                 310                 315                 320 


Ser Gly Pro Ser Gly Gly Val Gly Val Gly Val Gly Val Val Glu Ala 
                325                 330                 335     


Glu Ala Gly Arg Pro Arg Gly Arg Thr Gly Pro Leu Val Asn Arg Pro 
            340                 345                 350         


Ala Pro Leu Ala Asn Asn Arg Asp Pro Ile Val Ile Ser Asp Ser Pro 
        355                 360                 365             


Pro Ala Ser Pro His Arg Pro Pro Ala Ala Pro Met Pro Gly Ser Ala 
    370                 375                 380                 


Pro Arg Pro Gly Pro Pro Ala Ser Ala Ala Ala Ser Gly Pro Ala Arg 
385                 390                 395                 400 


Pro Arg Ala Ala Val Ala Pro Cys Val Arg Ala Pro Pro Pro Gly Pro 
                405                 410                 415     


Gly Pro Arg Ala Pro Ala Pro Gly Ala Glu Pro Ala Ala Arg Pro Ala 
            420                 425                 430         


Asp Ala Arg Arg Val Pro Gln Ser His Ser Ser Leu Ala Gln Ala Ala 
        435                 440                 445             


Asn Gln Glu Gln Ser Leu Cys Arg Ala Arg Ala Thr Val Ala Arg Gly 
    450                 455                 460                 


Ser Gly Gly Pro Gly Val Glu Gly Gly His Gly Pro Ser Arg Gly Ala 
465                 470                 475                 480 


Ala Pro Ser Gly Ala Ala Pro Leu Pro Ser Ala Ala Ser Val Glu Gln 
                485                 490                 495     


Glu Ala Ala Val Arg Pro Arg Lys Arg Arg Gly Ser Gly Gln Glu Asn 
            500                 505                 510         


Pro Ser Pro Gln Ser Thr Arg Pro Pro Leu Ala Pro Ala Gly Ala Lys 
        515                 520                 525             


Arg Ala Ala Thr His Pro Pro Ser Asp Ser Gly Pro Gly Gly Arg Gly 
    530                 535                 540                 


Gln Gly Gly Pro Gly Thr Pro Leu Thr Ser Ser Ala Ala Ser Ala Ser 
545                 550                 555                 560 


Ser Ser Ser Ala Ser Ser Ser Ser Ala Pro Thr Pro Ala Gly Ala Ala 
                565                 570                 575     


Ser Ser Ala Ala Gly Ala Ala Ser Ser Ser Ala Ser Ala Ser Ser Gly 
            580                 585                 590         


Gly Ala Val Gly Ala Leu Gly Gly Arg Gln Glu Glu Thr Ser Leu Gly 
        595                 600                 605             


Pro Arg Ala Ala Ser Gly Pro Arg Gly Pro Arg Lys Cys Ala Arg Lys 
    610                 615                 620                 


Thr Arg His Ala Glu Thr Ser Gly Ala Val Pro Ala Gly Gly Leu Thr 
625                 630                 635                 640 


Arg Tyr Leu Pro Ile Ser Gly Val Ser Ser Val Val Ala Leu Ser Pro 
                645                 650                 655     


Tyr Val Asn Lys Thr Ile Thr Gly Asp Cys Leu Pro Ile Leu Asp Met 
            660                 665                 670         


Glu Thr Gly Asn Ile Gly Ala Tyr Val Val Leu Val Asp Gln Thr Gly 
        675                 680                 685             


Asn Met Ala Thr Arg Leu Arg Ala Ala Val Pro Gly Trp Ser Arg Arg 
    690                 695                 700                 


Thr Leu Leu Pro Glu Thr Ala Gly Asn His Val Met Pro Pro Glu Tyr 
705                 710                 715                 720 


Pro Thr Ala Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro Val 
                725                 730                 735     


Gly Asn Met Leu Phe Asp Gln Gly Thr Leu Val Gly Ala Leu Asp Phe 
            740                 745                 750         


Arg Ser Leu Arg Ser Arg His Pro Trp Ser Gly Glu Gln Gly Ala Ser 
        755                 760                 765             


Thr Arg Asp Glu Gly Lys Gln 
    770                 775 


<210>  27
<211>  3591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  mutation
<222>  (3464)..(3464)
<223>  c3464t

<400>  27
atggagacaa agcccaagac ggcaaccacc atcaaggtcc cccccgggcc cctgggatac       60

gtgtacgctc gcgcgtgtcc gtccgaaggc atcgagcttc tggcgttact gtcggcacgc      120

agcggcgatt ccgacgtcgc cgtggcgccc ctggtcgtgg gcctgaccgt ggagagcggc      180

tttgaggcca acgtggccgt ggtcgtgggt tctcgcacga cggggctcgg gggtaccgcg      240

gtgtccctga aactgacgcc ctcgcactac agctcgtccg tgtacgtctt tcacggcggc      300

cggcacctgg accccagcac ccaggccccg aacctgacgc gactttgcga gcgggcacgc      360

cgccattttg gcttttcgga ctacaccccc cggcccggcg acctcaaaca cgagacgacg      420

ggggaggcgc tgtgtgagcg cctcggcctg gacccggacc gcgccctcct gtatctggtc      480

gttaccgagg gcttcaagga ggccgtgtgc atcaacaaca cctttctgca cctgggaggc      540

tcggacaagg taaccatagg cggggcggag gtgcaccgca tacccgtgta cccgttgcag      600

ctgttcatgc cggattttag ccgtgtcatc gcagagccgt tcaacgccaa ccaccgatcg      660

atcggggaga attttaccta cccgcttccg ttttttaacc gccccctcaa ccgcctcctg      720

ttcgaggcgg tcgtgggacc cgccgccgtg gcactgcgat gccgaaacgt ggacgccgtg      780

gcccgcgcgg ccgcccacct ggcgtttgac gaaaaccacg agggcgccgc cctccccgcc      840

gacattacgt tcacggcctt cgaagccagc cagggtaaga ccccgcgggg cgggcgcgac      900

ggcggcggca agggcccggc gggcgggttc gaacagcgcc tggcctccgt catggccgga      960

gacgccgccc tggccctcga ttctatcgtg tcgatggccg tctttgacga gccgcccacc     1020

gacatctccg cgtggccgct gttcgagggc caggacacgg ccgcggcccg cgccaacgcc     1080

gtcggggcgt acctggcgcg cgccgcggga ctcgtggggg ccatggtatt tagcaccaac     1140

tcggccctcc atctcaccga ggtggacgac gccggcccgg cggacccaaa ggaccacagc     1200

aaaccctcct tttaccgctt cttcctcgtg cccgggaccc acgtggcggc caacccacag     1260

gtggaccgcg agggacacgt ggtgcccggg ttcgagggtc ggcccaccgc gcccctcgtc     1320

ggcggaaccc aggaatttgc cggcgagcac ctggccatgc tgtgtgggtt ttccccggcg     1380

ctgctggcca agatgctgtt ttacctggag cgctgcgacg gcggcgtgat cgtcgggcgc     1440

caggagatgg acgtgtttcg atacgtcgcg gactccaacc agaccgacgt gccctgtaac     1500

ctatgcacct tcgacacgcg ccacgcctgc gtacacacga cgctcatgcg cctccgggcg     1560

cgccatccaa agttcgccag cgccgcccgc ggagccatcg gcgtcttcgg gaccatgaac     1620

agcatgtaca gcgactgcga cgtgctggga aactacgccg ccttctcggc cctgaagcgc     1680

gcggacggat ccgagaccgc ccggaccatc atgcaggaga cgtaccgcgc ggcgaccgag     1740

cgcgtcatgg ccgaactcga gaccctgcag tacgtggacc aggcggtccc cacggccatg     1800

gggcggctgg agaccatcat caccaaccgc gaggccctgc atacggtggt gaacaacgtc     1860

aggcaggtcg tggaccgcga ggtggagcag ctgatgcgca acctggtgga ggggaggaac     1920

ttcaagtttc gcgacggtct gggcgaggcc aaccacgcca tgtccctgac gctggacccg     1980

tacgcgtgcg ggccgtgccc cctgcttcag cttctcgggc ggcgatccaa cctcgccgtg     2040

taccaggacc tggccctgag tcagtgccac ggggtgttcg ccgggcagtc ggtcgagggg     2100

cgcaactttc gcaatcaatt ccaaccggtg ctgcggcggc gcgtgatgga catgtttaac     2160

aacgggtttc tgtcggccaa aacgctgacg gtcgcgctct cggagggggc ggctatctgc     2220

gcccccagcc taacggccgg ccagacggcc cccgccgaga gcagcttcga gggcgacgtt     2280

gcccgcgtga ccctggggtt tcccaaggag ctgcgcgtca agagccgcgt gttgttcgcg     2340

ggcgcgagcg ccaacgcgtc cgaggccgcc aaggcgcggg tcgccagcct ccagagcgcc     2400

taccagaagc ccgacaagcg cgtggacatc ctcctcggac cgctgggctt tctgctgaag     2460

cagttccacg cggccatctt ccccaacggc aagcccccgg ggtccaacca gccgaacccg     2520

cagtggttct ggacggccct ccaacgcaac cagcttcccg cccggctcct gtcgcgcgag     2580

gacatcgaga ccatcgcgtt cattaaaaag ttttccctgg actacggcgc gataaacttt     2640

attaacctgg cccccaacaa cgtgagcgag ctggcgatgt actacatggc aaaccagatt     2700

ctgcggtact gcgatcactc gacatacttc atcaacaccc ttacggccat catcgcgggg     2760

tcccgccgtc cccccagcgt gcaggctgcg gccgcgtggt ccgcgcaggg cggggcgggc     2820

ctggaggccg gggcccgcgc gctgatggac gccgtggacg cgcatccggg cgcgtggacg     2880

tccatgttcg ccagctgcaa cctgctgcgg cccgtcatgg cggcgcgccc catggtcgtg     2940

ttggggttga gcatcagcaa gtactacggc atggccggca acgaccgtgt gtttcaggcc     3000

gggaactggg ccagcctgat gggcggcaaa aacgcgtgcc cgctccttat ttttgaccgc     3060

acccgcaagt tcgtcctggc ctgtccccgg gccgggtttg tgtgcgcggc ctcaagcctc     3120

ggcggcggag cgcacgaaag ctcgctgtgc gagcagctcc ggggcattat ctccgagggc     3180

ggggcggccg tcgccagtag cgtgttcgtg gcgaccgtga aaagcctggg gccccgcacc     3240

cagcagctgc agatcgagga ctggctggcg ctcctggagg acgagtacct aagcgaggag     3300

atgatggagc tgaccgcgcg tgccctggag cgcggcaacg gcgagtggtc gacggacgcg     3360

gccctggagg tggcgcacga ggccgaggcc ctagtcagcc aactcggcaa cgccggggag     3420

gtgtttaact ttggggattt tggctgcgag gacgacaacg cgatgccgtt cggcggcccg     3480

ggggccccgg gaccggcatt tgccggccgc aaacgggcgt tccacgggga tgacccgttt     3540

ggggaggggc cccccgacaa aaagggagac ctgacgttgg atatgctgtg a              3591


<210>  28
<211>  1196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1155)..(1155)
<223>  T1155M

<400>  28

Met Glu Thr Lys Pro Lys Thr Ala Thr Thr Ile Lys Val Pro Pro Gly 
1               5                   10                  15      


Pro Leu Gly Tyr Val Tyr Ala Arg Ala Cys Pro Ser Glu Gly Ile Glu 
            20                  25                  30          


Leu Leu Ala Leu Leu Ser Ala Arg Ser Gly Asp Ser Asp Val Ala Val 
        35                  40                  45              


Ala Pro Leu Val Val Gly Leu Thr Val Glu Ser Gly Phe Glu Ala Asn 
    50                  55                  60                  


Val Ala Val Val Val Gly Ser Arg Thr Thr Gly Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Val Ser Leu Lys Leu Thr Pro Ser His Tyr Ser Ser Ser Val Tyr Val 
                85                  90                  95      


Phe His Gly Gly Arg His Leu Asp Pro Ser Thr Gln Ala Pro Asn Leu 
            100                 105                 110         


Thr Arg Leu Cys Glu Arg Ala Arg Arg His Phe Gly Phe Ser Asp Tyr 
        115                 120                 125             


Thr Pro Arg Pro Gly Asp Leu Lys His Glu Thr Thr Gly Glu Ala Leu 
    130                 135                 140                 


Cys Glu Arg Leu Gly Leu Asp Pro Asp Arg Ala Leu Leu Tyr Leu Val 
145                 150                 155                 160 


Val Thr Glu Gly Phe Lys Glu Ala Val Cys Ile Asn Asn Thr Phe Leu 
                165                 170                 175     


His Leu Gly Gly Ser Asp Lys Val Thr Ile Gly Gly Ala Glu Val His 
            180                 185                 190         


Arg Ile Pro Val Tyr Pro Leu Gln Leu Phe Met Pro Asp Phe Ser Arg 
        195                 200                 205             


Val Ile Ala Glu Pro Phe Asn Ala Asn His Arg Ser Ile Gly Glu Asn 
    210                 215                 220                 


Phe Thr Tyr Pro Leu Pro Phe Phe Asn Arg Pro Leu Asn Arg Leu Leu 
225                 230                 235                 240 


Phe Glu Ala Val Val Gly Pro Ala Ala Val Ala Leu Arg Cys Arg Asn 
                245                 250                 255     


Val Asp Ala Val Ala Arg Ala Ala Ala His Leu Ala Phe Asp Glu Asn 
            260                 265                 270         


His Glu Gly Ala Ala Leu Pro Ala Asp Ile Thr Phe Thr Ala Phe Glu 
        275                 280                 285             


Ala Ser Gln Gly Lys Thr Pro Arg Gly Gly Arg Asp Gly Gly Gly Lys 
    290                 295                 300                 


Gly Pro Ala Gly Gly Phe Glu Gln Arg Leu Ala Ser Val Met Ala Gly 
305                 310                 315                 320 


Asp Ala Ala Leu Ala Leu Asp Ser Ile Val Ser Met Ala Val Phe Asp 
                325                 330                 335     


Glu Pro Pro Thr Asp Ile Ser Ala Trp Pro Leu Phe Glu Gly Gln Asp 
            340                 345                 350         


Thr Ala Ala Ala Arg Ala Asn Ala Val Gly Ala Tyr Leu Ala Arg Ala 
        355                 360                 365             


Ala Gly Leu Val Gly Ala Met Val Phe Ser Thr Asn Ser Ala Leu His 
    370                 375                 380                 


Leu Thr Glu Val Asp Asp Ala Gly Pro Ala Asp Pro Lys Asp His Ser 
385                 390                 395                 400 


Lys Pro Ser Phe Tyr Arg Phe Phe Leu Val Pro Gly Thr His Val Ala 
                405                 410                 415     


Ala Asn Pro Gln Val Asp Arg Glu Gly His Val Val Pro Gly Phe Glu 
            420                 425                 430         


Gly Arg Pro Thr Ala Pro Leu Val Gly Gly Thr Gln Glu Phe Ala Gly 
        435                 440                 445             


Glu His Leu Ala Met Leu Cys Gly Phe Ser Pro Ala Leu Leu Ala Lys 
    450                 455                 460                 


Met Leu Phe Tyr Leu Glu Arg Cys Asp Gly Gly Val Ile Val Gly Arg 
465                 470                 475                 480 


Gln Glu Met Asp Val Phe Arg Tyr Val Ala Asp Ser Asn Gln Thr Asp 
                485                 490                 495     


Val Pro Cys Asn Leu Cys Thr Phe Asp Thr Arg His Ala Cys Val His 
            500                 505                 510         


Thr Thr Leu Met Arg Leu Arg Ala Arg His Pro Lys Phe Ala Ser Ala 
        515                 520                 525             


Ala Arg Gly Ala Ile Gly Val Phe Gly Thr Met Asn Ser Met Tyr Ser 
    530                 535                 540                 


Asp Cys Asp Val Leu Gly Asn Tyr Ala Ala Phe Ser Ala Leu Lys Arg 
545                 550                 555                 560 


Ala Asp Gly Ser Glu Thr Ala Arg Thr Ile Met Gln Glu Thr Tyr Arg 
                565                 570                 575     


Ala Ala Thr Glu Arg Val Met Ala Glu Leu Glu Thr Leu Gln Tyr Val 
            580                 585                 590         


Asp Gln Ala Val Pro Thr Ala Met Gly Arg Leu Glu Thr Ile Ile Thr 
        595                 600                 605             


Asn Arg Glu Ala Leu His Thr Val Val Asn Asn Val Arg Gln Val Val 
    610                 615                 620                 


Asp Arg Glu Val Glu Gln Leu Met Arg Asn Leu Val Glu Gly Arg Asn 
625                 630                 635                 640 


Phe Lys Phe Arg Asp Gly Leu Gly Glu Ala Asn His Ala Met Ser Leu 
                645                 650                 655     


Thr Leu Asp Pro Tyr Ala Cys Gly Pro Cys Pro Leu Leu Gln Leu Leu 
            660                 665                 670         


Gly Arg Arg Ser Asn Leu Ala Val Tyr Gln Asp Leu Ala Leu Ser Gln 
        675                 680                 685             


Cys His Gly Val Phe Ala Gly Gln Ser Val Glu Gly Arg Asn Phe Arg 
    690                 695                 700                 


Asn Gln Phe Gln Pro Val Leu Arg Arg Arg Val Met Asp Met Phe Asn 
705                 710                 715                 720 


Asn Gly Phe Leu Ser Ala Lys Thr Leu Thr Val Ala Leu Ser Glu Gly 
                725                 730                 735     


Ala Ala Ile Cys Ala Pro Ser Leu Thr Ala Gly Gln Thr Ala Pro Ala 
            740                 745                 750         


Glu Ser Ser Phe Glu Gly Asp Val Ala Arg Val Thr Leu Gly Phe Pro 
        755                 760                 765             


Lys Glu Leu Arg Val Lys Ser Arg Val Leu Phe Ala Gly Ala Ser Ala 
    770                 775                 780                 


Asn Ala Ser Glu Ala Ala Lys Ala Arg Val Ala Ser Leu Gln Ser Ala 
785                 790                 795                 800 


Tyr Gln Lys Pro Asp Lys Arg Val Asp Ile Leu Leu Gly Pro Leu Gly 
                805                 810                 815     


Phe Leu Leu Lys Gln Phe His Ala Ala Ile Phe Pro Asn Gly Lys Pro 
            820                 825                 830         


Pro Gly Ser Asn Gln Pro Asn Pro Gln Trp Phe Trp Thr Ala Leu Gln 
        835                 840                 845             


Arg Asn Gln Leu Pro Ala Arg Leu Leu Ser Arg Glu Asp Ile Glu Thr 
    850                 855                 860                 


Ile Ala Phe Ile Lys Lys Phe Ser Leu Asp Tyr Gly Ala Ile Asn Phe 
865                 870                 875                 880 


Ile Asn Leu Ala Pro Asn Asn Val Ser Glu Leu Ala Met Tyr Tyr Met 
                885                 890                 895     


Ala Asn Gln Ile Leu Arg Tyr Cys Asp His Ser Thr Tyr Phe Ile Asn 
            900                 905                 910         


Thr Leu Thr Ala Ile Ile Ala Gly Ser Arg Arg Pro Pro Ser Val Gln 
        915                 920                 925             


Ala Ala Ala Ala Trp Ser Ala Gln Gly Gly Ala Gly Leu Glu Ala Gly 
    930                 935                 940                 


Ala Arg Ala Leu Met Asp Ala Val Asp Ala His Pro Gly Ala Trp Thr 
945                 950                 955                 960 


Ser Met Phe Ala Ser Cys Asn Leu Leu Arg Pro Val Met Ala Ala Arg 
                965                 970                 975     


Pro Met Val Val Leu Gly Leu Ser Ile Ser Lys Tyr Tyr Gly Met Ala 
            980                 985                 990         


Gly Asn Asp Arg Val Phe Gln Ala  Gly Asn Trp Ala Ser  Leu Met Gly 
        995                 1000                 1005             


Gly Lys  Asn Ala Cys Pro Leu  Leu Ile Phe Asp Arg  Thr Arg Lys 
    1010                 1015                 1020             


Phe Val  Leu Ala Cys Pro Arg  Ala Gly Phe Val Cys  Ala Ala Ser 
    1025                 1030                 1035             


Ser Leu  Gly Gly Gly Ala His  Glu Ser Ser Leu Cys  Glu Gln Leu 
    1040                 1045                 1050             


Arg Gly  Ile Ile Ser Glu Gly  Gly Ala Ala Val Ala  Ser Ser Val 
    1055                 1060                 1065             


Phe Val  Ala Thr Val Lys Ser  Leu Gly Pro Arg Thr  Gln Gln Leu 
    1070                 1075                 1080             


Gln Ile  Glu Asp Trp Leu Ala  Leu Leu Glu Asp Glu  Tyr Leu Ser 
    1085                 1090                 1095             


Glu Glu  Met Met Glu Leu Thr  Ala Arg Ala Leu Glu  Arg Gly Asn 
    1100                 1105                 1110             


Gly Glu  Trp Ser Thr Asp Ala  Ala Leu Glu Val Ala  His Glu Ala 
    1115                 1120                 1125             


Glu Ala  Leu Val Ser Gln Leu  Gly Asn Ala Gly Glu  Val Phe Asn 
    1130                 1135                 1140             


Phe Gly  Asp Phe Gly Cys Glu  Asp Asp Asn Ala Met  Pro Phe Gly 
    1145                 1150                 1155             


Gly Pro  Gly Ala Pro Gly Pro  Ala Phe Ala Gly Arg  Lys Arg Ala 
    1160                 1165                 1170             


Phe His  Gly Asp Asp Pro Phe  Gly Glu Gly Pro Pro  Asp Lys Lys 
    1175                 1180                 1185             


Gly Asp  Leu Thr Leu Asp Met  Leu 
    1190                 1195     


<210>  29
<211>  3591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  29
atggagacaa agcccaagac ggcaaccacc atcaaggtcc cccccgggcc cctgggatac       60

gtgtacgctc gcgcgtgtcc gtccgaaggc atcgagcttc tggcgttact gtcggcacgc      120

agcggcgatt ccgacgtcgc cgtggcgccc ctggtcgtgg gcctgaccgt ggagagcggc      180

tttgaggcca acgtggccgt ggtcgtgggt tctcgcacga cggggctcgg gggtaccgcg      240

gtgtccctga aactgacgcc ctcgcactac agctcgtccg tgtacgtctt tcacggcggc      300

cggcacctgg accccagcac ccaggccccg aacctgacgc gactttgcga gcgggcacgc      360

cgccattttg gcttttcgga ctacaccccc cggcccggcg acctcaaaca cgagacgacg      420

ggggaggcgc tgtgtgagcg cctcggcctg gacccggacc gcgccctcct gtatctggtc      480

gttaccgagg gcttcaagga ggccgtgtgc atcaacaaca cctttctgca cctgggaggc      540

tcggacaagg taaccatagg cggggcggag gtgcaccgca tacccgtgta cccgttgcag      600

ctgttcatgc cggattttag ccgtgtcatc gcagagccgt tcaacgccaa ccaccgatcg      660

atcggggaga attttaccta cccgcttccg ttttttaacc gccccctcaa ccgcctcctg      720

ttcgaggcgg tcgtgggacc cgccgccgtg gcactgcgat gccgaaacgt ggacgccgtg      780

gcccgcgcgg ccgcccacct ggcgtttgac gaaaaccacg agggcgccgc cctccccgcc      840

gacattacgt tcacggcctt cgaagccagc cagggtaaga ccccgcgggg cgggcgcgac      900

ggcggcggca agggcccggc gggcgggttc gaacagcgcc tggcctccgt catggccgga      960

gacgccgccc tggccctcga ttctatcgtg tcgatggccg tctttgacga gccgcccacc     1020

gacatctccg cgtggccgct gttcgagggc caggacacgg ccgcggcccg cgccaacgcc     1080

gtcggggcgt acctggcgcg cgccgcggga ctcgtggggg ccatggtatt tagcaccaac     1140

tcggccctcc atctcaccga ggtggacgac gccggcccgg cggacccaaa ggaccacagc     1200

aaaccctcct tttaccgctt cttcctcgtg cccgggaccc acgtggcggc caacccacag     1260

gtggaccgcg agggacacgt ggtgcccggg ttcgagggtc ggcccaccgc gcccctcgtc     1320

ggcggaaccc aggaatttgc cggcgagcac ctggccatgc tgtgtgggtt ttccccggcg     1380

ctgctggcca agatgctgtt ttacctggag cgctgcgacg gcggcgtgat cgtcgggcgc     1440

caggagatgg acgtgtttcg atacgtcgcg gactccaacc agaccgacgt gccctgtaac     1500

ctatgcacct tcgacacgcg ccacgcctgc gtacacacga cgctcatgcg cctccgggcg     1560

cgccatccaa agttcgccag cgccgcccgc ggagccatcg gcgtcttcgg gaccatgaac     1620

agcatgtaca gcgactgcga cgtgctggga aactacgccg ccttctcggc cctgaagcgc     1680

gcggacggat ccgagaccgc ccggaccatc atgcaggaga cgtaccgcgc ggcgaccgag     1740

cgcgtcatgg ccgaactcga gaccctgcag tacgtggacc aggcggtccc cacggccatg     1800

gggcggctgg agaccatcat caccaaccgc gaggccctgc atacggtggt gaacaacgtc     1860

aggcaggtcg tggaccgcga ggtggagcag ctgatgcgca acctggtgga ggggaggaac     1920

ttcaagtttc gcgacggtct gggcgaggcc aaccacgcca tgtccctgac gctggacccg     1980

tacgcgtgcg ggccgtgccc cctgcttcag cttctcgggc ggcgatccaa cctcgccgtg     2040

taccaggacc tggccctgag tcagtgccac ggggtgttcg ccgggcagtc ggtcgagggg     2100

cgcaactttc gcaatcaatt ccaaccggtg ctgcggcggc gcgtgatgga catgtttaac     2160

aacgggtttc tgtcggccaa aacgctgacg gtcgcgctct cggagggggc ggctatctgc     2220

gcccccagcc taacggccgg ccagacggcc cccgccgaga gcagcttcga gggcgacgtt     2280

gcccgcgtga ccctggggtt tcccaaggag ctgcgcgtca agagccgcgt gttgttcgcg     2340

ggcgcgagcg ccaacgcgtc cgaggccgcc aaggcgcggg tcgccagcct ccagagcgcc     2400

taccagaagc ccgacaagcg cgtggacatc ctcctcggac cgctgggctt tctgctgaag     2460

cagttccacg cggccatctt ccccaacggc aagcccccgg ggtccaacca gccgaacccg     2520

cagtggttct ggacggccct ccaacgcaac cagcttcccg cccggctcct gtcgcgcgag     2580

gacatcgaga ccatcgcgtt cattaaaaag ttttccctgg actacggcgc gataaacttt     2640

attaacctgg cccccaacaa cgtgagcgag ctggcgatgt actacatggc aaaccagatt     2700

ctgcggtact gcgatcactc gacatacttc atcaacaccc ttacggccat catcgcgggg     2760

tcccgccgtc cccccagcgt gcaggctgcg gccgcgtggt ccgcgcaggg cggggcgggc     2820

ctggaggccg gggcccgcgc gctgatggac gccgtggacg cgcatccggg cgcgtggacg     2880

tccatgttcg ccagctgcaa cctgctgcgg cccgtcatgg cggcgcgccc catggtcgtg     2940

ttggggttga gcatcagcaa gtactacggc atggccggca acgaccgtgt gtttcaggcc     3000

gggaactggg ccagcctgat gggcggcaaa aacgcgtgcc cgctccttat ttttgaccgc     3060

acccgcaagt tcgtcctggc ctgtccccgg gccgggtttg tgtgcgcggc ctcaagcctc     3120

ggcggcggag cgcacgaaag ctcgctgtgc gagcagctcc ggggcattat ctccgagggc     3180

ggggcggccg tcgccagtag cgtgttcgtg gcgaccgtga aaagcctggg gccccgcacc     3240

cagcagctgc agatcgagga ctggctggcg ctcctggagg acgagtacct aagcgaggag     3300

atgatggagc tgaccgcgcg tgccctggag cgcggcaacg gcgagtggtc gacggacgcg     3360

gccctggagg tggcgcacga ggccgaggcc ctagtcagcc aactcggcaa cgccggggag     3420

gtgtttaact ttggggattt tggctgcgag gacgacaacg cgacgccgtt cggcggcccg     3480

ggggccccgg gaccggcatt tgccggccgc aaacgggcgt tccacgggga tgacccgttt     3540

ggggaggggc cccccgacaa aaagggagac ctgacgttgg atatgctgtg a              3591


<210>  30
<211>  1196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  30

Met Glu Thr Lys Pro Lys Thr Ala Thr Thr Ile Lys Val Pro Pro Gly 
1               5                   10                  15      


Pro Leu Gly Tyr Val Tyr Ala Arg Ala Cys Pro Ser Glu Gly Ile Glu 
            20                  25                  30          


Leu Leu Ala Leu Leu Ser Ala Arg Ser Gly Asp Ser Asp Val Ala Val 
        35                  40                  45              


Ala Pro Leu Val Val Gly Leu Thr Val Glu Ser Gly Phe Glu Ala Asn 
    50                  55                  60                  


Val Ala Val Val Val Gly Ser Arg Thr Thr Gly Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Val Ser Leu Lys Leu Thr Pro Ser His Tyr Ser Ser Ser Val Tyr Val 
                85                  90                  95      


Phe His Gly Gly Arg His Leu Asp Pro Ser Thr Gln Ala Pro Asn Leu 
            100                 105                 110         


Thr Arg Leu Cys Glu Arg Ala Arg Arg His Phe Gly Phe Ser Asp Tyr 
        115                 120                 125             


Thr Pro Arg Pro Gly Asp Leu Lys His Glu Thr Thr Gly Glu Ala Leu 
    130                 135                 140                 


Cys Glu Arg Leu Gly Leu Asp Pro Asp Arg Ala Leu Leu Tyr Leu Val 
145                 150                 155                 160 


Val Thr Glu Gly Phe Lys Glu Ala Val Cys Ile Asn Asn Thr Phe Leu 
                165                 170                 175     


His Leu Gly Gly Ser Asp Lys Val Thr Ile Gly Gly Ala Glu Val His 
            180                 185                 190         


Arg Ile Pro Val Tyr Pro Leu Gln Leu Phe Met Pro Asp Phe Ser Arg 
        195                 200                 205             


Val Ile Ala Glu Pro Phe Asn Ala Asn His Arg Ser Ile Gly Glu Asn 
    210                 215                 220                 


Phe Thr Tyr Pro Leu Pro Phe Phe Asn Arg Pro Leu Asn Arg Leu Leu 
225                 230                 235                 240 


Phe Glu Ala Val Val Gly Pro Ala Ala Val Ala Leu Arg Cys Arg Asn 
                245                 250                 255     


Val Asp Ala Val Ala Arg Ala Ala Ala His Leu Ala Phe Asp Glu Asn 
            260                 265                 270         


His Glu Gly Ala Ala Leu Pro Ala Asp Ile Thr Phe Thr Ala Phe Glu 
        275                 280                 285             


Ala Ser Gln Gly Lys Thr Pro Arg Gly Gly Arg Asp Gly Gly Gly Lys 
    290                 295                 300                 


Gly Pro Ala Gly Gly Phe Glu Gln Arg Leu Ala Ser Val Met Ala Gly 
305                 310                 315                 320 


Asp Ala Ala Leu Ala Leu Asp Ser Ile Val Ser Met Ala Val Phe Asp 
                325                 330                 335     


Glu Pro Pro Thr Asp Ile Ser Ala Trp Pro Leu Phe Glu Gly Gln Asp 
            340                 345                 350         


Thr Ala Ala Ala Arg Ala Asn Ala Val Gly Ala Tyr Leu Ala Arg Ala 
        355                 360                 365             


Ala Gly Leu Val Gly Ala Met Val Phe Ser Thr Asn Ser Ala Leu His 
    370                 375                 380                 


Leu Thr Glu Val Asp Asp Ala Gly Pro Ala Asp Pro Lys Asp His Ser 
385                 390                 395                 400 


Lys Pro Ser Phe Tyr Arg Phe Phe Leu Val Pro Gly Thr His Val Ala 
                405                 410                 415     


Ala Asn Pro Gln Val Asp Arg Glu Gly His Val Val Pro Gly Phe Glu 
            420                 425                 430         


Gly Arg Pro Thr Ala Pro Leu Val Gly Gly Thr Gln Glu Phe Ala Gly 
        435                 440                 445             


Glu His Leu Ala Met Leu Cys Gly Phe Ser Pro Ala Leu Leu Ala Lys 
    450                 455                 460                 


Met Leu Phe Tyr Leu Glu Arg Cys Asp Gly Gly Val Ile Val Gly Arg 
465                 470                 475                 480 


Gln Glu Met Asp Val Phe Arg Tyr Val Ala Asp Ser Asn Gln Thr Asp 
                485                 490                 495     


Val Pro Cys Asn Leu Cys Thr Phe Asp Thr Arg His Ala Cys Val His 
            500                 505                 510         


Thr Thr Leu Met Arg Leu Arg Ala Arg His Pro Lys Phe Ala Ser Ala 
        515                 520                 525             


Ala Arg Gly Ala Ile Gly Val Phe Gly Thr Met Asn Ser Met Tyr Ser 
    530                 535                 540                 


Asp Cys Asp Val Leu Gly Asn Tyr Ala Ala Phe Ser Ala Leu Lys Arg 
545                 550                 555                 560 


Ala Asp Gly Ser Glu Thr Ala Arg Thr Ile Met Gln Glu Thr Tyr Arg 
                565                 570                 575     


Ala Ala Thr Glu Arg Val Met Ala Glu Leu Glu Thr Leu Gln Tyr Val 
            580                 585                 590         


Asp Gln Ala Val Pro Thr Ala Met Gly Arg Leu Glu Thr Ile Ile Thr 
        595                 600                 605             


Asn Arg Glu Ala Leu His Thr Val Val Asn Asn Val Arg Gln Val Val 
    610                 615                 620                 


Asp Arg Glu Val Glu Gln Leu Met Arg Asn Leu Val Glu Gly Arg Asn 
625                 630                 635                 640 


Phe Lys Phe Arg Asp Gly Leu Gly Glu Ala Asn His Ala Met Ser Leu 
                645                 650                 655     


Thr Leu Asp Pro Tyr Ala Cys Gly Pro Cys Pro Leu Leu Gln Leu Leu 
            660                 665                 670         


Gly Arg Arg Ser Asn Leu Ala Val Tyr Gln Asp Leu Ala Leu Ser Gln 
        675                 680                 685             


Cys His Gly Val Phe Ala Gly Gln Ser Val Glu Gly Arg Asn Phe Arg 
    690                 695                 700                 


Asn Gln Phe Gln Pro Val Leu Arg Arg Arg Val Met Asp Met Phe Asn 
705                 710                 715                 720 


Asn Gly Phe Leu Ser Ala Lys Thr Leu Thr Val Ala Leu Ser Glu Gly 
                725                 730                 735     


Ala Ala Ile Cys Ala Pro Ser Leu Thr Ala Gly Gln Thr Ala Pro Ala 
            740                 745                 750         


Glu Ser Ser Phe Glu Gly Asp Val Ala Arg Val Thr Leu Gly Phe Pro 
        755                 760                 765             


Lys Glu Leu Arg Val Lys Ser Arg Val Leu Phe Ala Gly Ala Ser Ala 
    770                 775                 780                 


Asn Ala Ser Glu Ala Ala Lys Ala Arg Val Ala Ser Leu Gln Ser Ala 
785                 790                 795                 800 


Tyr Gln Lys Pro Asp Lys Arg Val Asp Ile Leu Leu Gly Pro Leu Gly 
                805                 810                 815     


Phe Leu Leu Lys Gln Phe His Ala Ala Ile Phe Pro Asn Gly Lys Pro 
            820                 825                 830         


Pro Gly Ser Asn Gln Pro Asn Pro Gln Trp Phe Trp Thr Ala Leu Gln 
        835                 840                 845             


Arg Asn Gln Leu Pro Ala Arg Leu Leu Ser Arg Glu Asp Ile Glu Thr 
    850                 855                 860                 


Ile Ala Phe Ile Lys Lys Phe Ser Leu Asp Tyr Gly Ala Ile Asn Phe 
865                 870                 875                 880 


Ile Asn Leu Ala Pro Asn Asn Val Ser Glu Leu Ala Met Tyr Tyr Met 
                885                 890                 895     


Ala Asn Gln Ile Leu Arg Tyr Cys Asp His Ser Thr Tyr Phe Ile Asn 
            900                 905                 910         


Thr Leu Thr Ala Ile Ile Ala Gly Ser Arg Arg Pro Pro Ser Val Gln 
        915                 920                 925             


Ala Ala Ala Ala Trp Ser Ala Gln Gly Gly Ala Gly Leu Glu Ala Gly 
    930                 935                 940                 


Ala Arg Ala Leu Met Asp Ala Val Asp Ala His Pro Gly Ala Trp Thr 
945                 950                 955                 960 


Ser Met Phe Ala Ser Cys Asn Leu Leu Arg Pro Val Met Ala Ala Arg 
                965                 970                 975     


Pro Met Val Val Leu Gly Leu Ser Ile Ser Lys Tyr Tyr Gly Met Ala 
            980                 985                 990         


Gly Asn Asp Arg Val Phe Gln Ala  Gly Asn Trp Ala Ser  Leu Met Gly 
        995                 1000                 1005             


Gly Lys  Asn Ala Cys Pro Leu  Leu Ile Phe Asp Arg  Thr Arg Lys 
    1010                 1015                 1020             


Phe Val  Leu Ala Cys Pro Arg  Ala Gly Phe Val Cys  Ala Ala Ser 
    1025                 1030                 1035             


Ser Leu  Gly Gly Gly Ala His  Glu Ser Ser Leu Cys  Glu Gln Leu 
    1040                 1045                 1050             


Arg Gly  Ile Ile Ser Glu Gly  Gly Ala Ala Val Ala  Ser Ser Val 
    1055                 1060                 1065             


Phe Val  Ala Thr Val Lys Ser  Leu Gly Pro Arg Thr  Gln Gln Leu 
    1070                 1075                 1080             


Gln Ile  Glu Asp Trp Leu Ala  Leu Leu Glu Asp Glu  Tyr Leu Ser 
    1085                 1090                 1095             


Glu Glu  Met Met Glu Leu Thr  Ala Arg Ala Leu Glu  Arg Gly Asn 
    1100                 1105                 1110             


Gly Glu  Trp Ser Thr Asp Ala  Ala Leu Glu Val Ala  His Glu Ala 
    1115                 1120                 1125             


Glu Ala  Leu Val Ser Gln Leu  Gly Asn Ala Gly Glu  Val Phe Asn 
    1130                 1135                 1140             


Phe Gly  Asp Phe Gly Cys Glu  Asp Asp Asn Ala Thr  Pro Phe Gly 
    1145                 1150                 1155             


Gly Pro  Gly Ala Pro Gly Pro  Ala Phe Ala Gly Arg  Lys Arg Ala 
    1160                 1165                 1170             


Phe His  Gly Asp Asp Pro Phe  Gly Glu Gly Pro Pro  Asp Lys Lys 
    1175                 1180                 1185             


Gly Asp  Leu Thr Leu Asp Met  Leu 
    1190                 1195     


<210>  31
<211>  3591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  31
atggagacaa agcccaagac ggcaaccacc atcaaggtcc cccccgggcc cctgggatac       60

gtgtacgctc gcgcgtgtcc gtccgaaggc atcgagcttc tggcgttact gtcggcgcgc      120

agcggcgatg ccgacgtcgc cgtggcgccc ctggtcgtgg gcctgaccgt ggagagcggc      180

tttgaggcca acgtagccgt ggtcgtgggt tctcgcacga cggggctcgg gggtaccgcg      240

gtgtccctga aactgacgcc atcgcactac agctcgtccg tgtacgtctt tcacggcggc      300

cggcacctgg accccagcac ccaggcccca aacctgacgc gactctgcga gcgggcacgc      360

cgccattttg gcttttcgga ctacaccccc cggcccggcg acctcaaaca cgagacgacg      420

ggggaggcgc tgtgtgagcg cctcggcctg gacccggacc gcgccctcct gtatctggtc      480

gttaccgagg gcttcaagga ggccgtgtgc atcaacaaca cctttctgca cctgggaggc      540

tcggacaagg taaccatagg cggggcggag gtgcaccgca tacccgtgta tccgttgcag      600

ctgttcatgc cggattttag ccgggtcatc gccgagccgt tcaacgccaa ccaccgatcg      660

atcggggaga attttaccta cccgcttccg ttttttaacc gccccctcaa ccgcctcctg      720

ttcgaggcgg tcgtgggacc cgccgccgtg gcactgcgat gccgaaacgt ggacgccgtg      780

gcccgcgcgg ccgcccacct ggcgtttgac gaaaaccacg agggcgccgc cctccccgcc      840

gacattacgt tcacggcctt cgaagccagc cagggtaaga ccccgcgggg tgggcgcgac      900

ggcggcggca agggcccggc gggcgggttc gaacagcgcc tggcctccgt catggccgga      960

gacgccgccc tggccctcga gtctatcgtg tcgatggccg tcttcgacga gccgcccacc     1020

gacatctccg cgtggccgct gtgcgagggc caggacacgg ccgcggcccg cgacaacgcc     1080

gtcggggcgt acctggcgcg cgccgcggga ctcgtggggg ccatggtatt tagcaccaac     1140

tcggccctcc atctcaccga ggtggacgac gccggtccgg cggacccaaa ggaccacagc     1200

aaaccctcct tttaccgctt cttcctcgtg cccgggaccc acgtggcggc caacccacag     1260

gtggaccgcg agggacacgt ggtgcccggg ttcgagggtc ggcccaccgc gcccctcgtc     1320

ggcggaaccc aggaatttgc cggcgagcac ctggccatgc tgtgtgggtt ttccccggcg     1380

ctgctggcca agatgctgtt ttacctggag cgctgcgacg gcggcgtgat cgtcgggcgc     1440

caggagatgg acgtgtttcg atacgtcgcg gactccaacc agaccgacgt gccctgcaac     1500

ctgtgcacct tcgacacgcg ccacgcctgc gtacacacga cgctcatgcg cctccgggcg     1560

cgccatccca agttcgccag cgccgcccgc ggagccatcg gcgtcttcgg gaccatgaac     1620

agcatgtaca gcgactgcga cgtgctggga aactacgccg ccttctcggc cctgaagcgc     1680

gcggacggat ccgagaccgc ccggaccatc atgcaggaga cgtaccgcgc ggcgaccgag     1740

cgcgtcatgg ccgaactcga gaccctgcag tacgtggacc aggcggtccc cacggccatg     1800

gggcggctgg agaccatcat caccaaccgc gaggccctgc atacggtggt gaacaacgtc     1860

aggcaggtcg tggaccgcga ggtggagcag ctgatgcgca acctggtgga ggggaggaac     1920

ttcaagtttc gcgacggtct gggcgaggcc aaccacgcca tgtccctgac gctggacccg     1980

tacgcgtgcg ggccatgccc cctgcttcag cttctcgggc ggcgatccaa cctcgccgtg     2040

tatcaggacc tggccctgag ccagtgccac ggggtgttcg ccgggcagtc ggtcgagggg     2100

cgcaactttc gcaatcaatt ccaaccggtg ctgcggcggc gcgtgatgga catgtttaac     2160

aacgggtttc tgtcggccaa aacgctgacg gtcgcgctct cggagggggc ggctatctgc     2220

gcccccagcc taacggccgg ccagacggcc cccgccgaga gcagcttcga gggcgacgtt     2280

gcccgcgtga ccctggggtt tcccaaggag ctgcgcgtca agagccgcgt gttgttcgcg     2340

ggcgcgagcg ccaacgcgtc cgaggccgcc aaggcgcggg tcgccagcct ccagagcgcc     2400

taccagaagc ccgacaagcg cgtggacatc ctcctcggac cgctgggctt tctgctgaag     2460

cagttccacg cggccatctt ccccaacggc aagcccccgg ggtccaacca gccgaacccg     2520

cagtggttct ggacggccct ccaacgcaac cagcttcccg cccggctcct gtcgcgcgag     2580

gacatcgaga ccatcgcgtt cattaaaaag ttttccctgg actacggcgc gataaacttt     2640

attaacctgg cccccaacaa cgtgagcgag ctggcgatgt actacatggc aaaccagatt     2700

ctgcggtact gcgatcactc gacatacttc atcaacaccc tcacggccat catcgcgggg     2760

tcccgccgtc cccccagcgt gcaggcggcg gccgcgtggt ccgcgcaggg cggggcgggc     2820

ctggaggccg gggcccgcgc gctgatggac gccgtggacg cgcatccggg cgcgtggacg     2880

tccatgttcg ccagctgcaa cctgctgcgg cccgtcatgg cggcgcgccc catggtcgtg     2940

ttggggttga gcatcagcaa atactacggc atggccggca acgaccgtgt gtttcaggcc     3000

gggaactggg ccagcctgat gggcggcaaa aacgcgtgcc cgctccttat ttttgaccgc     3060

acccgcaagt tcgtcctggc ctgtccccgg gccgggtttg tgtgcgcggc ctcgaacctc     3120

ggcggcggag cgcacgaaag ctcgctgtgc gagcagctcc ggggcattat ctccgagggc     3180

ggggcggccg tcgccagtag cgtgttcgtg gcgaccgtga aaagcctggg gccccgcacc     3240

cagcagctgc agatcgagga ctggctggcg ctcctggagg acgagtacct aagcgaggag     3300

atgatggagc tgaccgcgcg tgccctggag cgcggcaacg gcgagtggtc gacggacgcg     3360

gccctggagg tggcgcacga ggccgaggcc ctagtcagcc aactcggcaa cgccggggag     3420

gtgtttaact ttggggattt tggctgcgag gacgacaacg cgacgccgtt cggcggcccg     3480

ggggccccgg gaccggcatt tgccggccgc aaacgggcgt tccacgggga tgacccgttt     3540

ggggaggggc cccccgacaa aaagggagac ctgacgttgg atatgctgtg a              3591


<210>  32
<211>  1196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  32

Met Glu Thr Lys Pro Lys Thr Ala Thr Thr Ile Lys Val Pro Pro Gly 
1               5                   10                  15      


Pro Leu Gly Tyr Val Tyr Ala Arg Ala Cys Pro Ser Glu Gly Ile Glu 
            20                  25                  30          


Leu Leu Ala Leu Leu Ser Ala Arg Ser Gly Asp Ala Asp Val Ala Val 
        35                  40                  45              


Ala Pro Leu Val Val Gly Leu Thr Val Glu Ser Gly Phe Glu Ala Asn 
    50                  55                  60                  


Val Ala Val Val Val Gly Ser Arg Thr Thr Gly Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Val Ser Leu Lys Leu Thr Pro Ser His Tyr Ser Ser Ser Val Tyr Val 
                85                  90                  95      


Phe His Gly Gly Arg His Leu Asp Pro Ser Thr Gln Ala Pro Asn Leu 
            100                 105                 110         


Thr Arg Leu Cys Glu Arg Ala Arg Arg His Phe Gly Phe Ser Asp Tyr 
        115                 120                 125             


Thr Pro Arg Pro Gly Asp Leu Lys His Glu Thr Thr Gly Glu Ala Leu 
    130                 135                 140                 


Cys Glu Arg Leu Gly Leu Asp Pro Asp Arg Ala Leu Leu Tyr Leu Val 
145                 150                 155                 160 


Val Thr Glu Gly Phe Lys Glu Ala Val Cys Ile Asn Asn Thr Phe Leu 
                165                 170                 175     


His Leu Gly Gly Ser Asp Lys Val Thr Ile Gly Gly Ala Glu Val His 
            180                 185                 190         


Arg Ile Pro Val Tyr Pro Leu Gln Leu Phe Met Pro Asp Phe Ser Arg 
        195                 200                 205             


Val Ile Ala Glu Pro Phe Asn Ala Asn His Arg Ser Ile Gly Glu Asn 
    210                 215                 220                 


Phe Thr Tyr Pro Leu Pro Phe Phe Asn Arg Pro Leu Asn Arg Leu Leu 
225                 230                 235                 240 


Phe Glu Ala Val Val Gly Pro Ala Ala Val Ala Leu Arg Cys Arg Asn 
                245                 250                 255     


Val Asp Ala Val Ala Arg Ala Ala Ala His Leu Ala Phe Asp Glu Asn 
            260                 265                 270         


His Glu Gly Ala Ala Leu Pro Ala Asp Ile Thr Phe Thr Ala Phe Glu 
        275                 280                 285             


Ala Ser Gln Gly Lys Thr Pro Arg Gly Gly Arg Asp Gly Gly Gly Lys 
    290                 295                 300                 


Gly Pro Ala Gly Gly Phe Glu Gln Arg Leu Ala Ser Val Met Ala Gly 
305                 310                 315                 320 


Asp Ala Ala Leu Ala Leu Glu Ser Ile Val Ser Met Ala Val Phe Asp 
                325                 330                 335     


Glu Pro Pro Thr Asp Ile Ser Ala Trp Pro Leu Cys Glu Gly Gln Asp 
            340                 345                 350         


Thr Ala Ala Ala Arg Asp Asn Ala Val Gly Ala Tyr Leu Ala Arg Ala 
        355                 360                 365             


Ala Gly Leu Val Gly Ala Met Val Phe Ser Thr Asn Ser Ala Leu His 
    370                 375                 380                 


Leu Thr Glu Val Asp Asp Ala Gly Pro Ala Asp Pro Lys Asp His Ser 
385                 390                 395                 400 


Lys Pro Ser Phe Tyr Arg Phe Phe Leu Val Pro Gly Thr His Val Ala 
                405                 410                 415     


Ala Asn Pro Gln Val Asp Arg Glu Gly His Val Val Pro Gly Phe Glu 
            420                 425                 430         


Gly Arg Pro Thr Ala Pro Leu Val Gly Gly Thr Gln Glu Phe Ala Gly 
        435                 440                 445             


Glu His Leu Ala Met Leu Cys Gly Phe Ser Pro Ala Leu Leu Ala Lys 
    450                 455                 460                 


Met Leu Phe Tyr Leu Glu Arg Cys Asp Gly Gly Val Ile Val Gly Arg 
465                 470                 475                 480 


Gln Glu Met Asp Val Phe Arg Tyr Val Ala Asp Ser Asn Gln Thr Asp 
                485                 490                 495     


Val Pro Cys Asn Leu Cys Thr Phe Asp Thr Arg His Ala Cys Val His 
            500                 505                 510         


Thr Thr Leu Met Arg Leu Arg Ala Arg His Pro Lys Phe Ala Ser Ala 
        515                 520                 525             


Ala Arg Gly Ala Ile Gly Val Phe Gly Thr Met Asn Ser Met Tyr Ser 
    530                 535                 540                 


Asp Cys Asp Val Leu Gly Asn Tyr Ala Ala Phe Ser Ala Leu Lys Arg 
545                 550                 555                 560 


Ala Asp Gly Ser Glu Thr Ala Arg Thr Ile Met Gln Glu Thr Tyr Arg 
                565                 570                 575     


Ala Ala Thr Glu Arg Val Met Ala Glu Leu Glu Thr Leu Gln Tyr Val 
            580                 585                 590         


Asp Gln Ala Val Pro Thr Ala Met Gly Arg Leu Glu Thr Ile Ile Thr 
        595                 600                 605             


Asn Arg Glu Ala Leu His Thr Val Val Asn Asn Val Arg Gln Val Val 
    610                 615                 620                 


Asp Arg Glu Val Glu Gln Leu Met Arg Asn Leu Val Glu Gly Arg Asn 
625                 630                 635                 640 


Phe Lys Phe Arg Asp Gly Leu Gly Glu Ala Asn His Ala Met Ser Leu 
                645                 650                 655     


Thr Leu Asp Pro Tyr Ala Cys Gly Pro Cys Pro Leu Leu Gln Leu Leu 
            660                 665                 670         


Gly Arg Arg Ser Asn Leu Ala Val Tyr Gln Asp Leu Ala Leu Ser Gln 
        675                 680                 685             


Cys His Gly Val Phe Ala Gly Gln Ser Val Glu Gly Arg Asn Phe Arg 
    690                 695                 700                 


Asn Gln Phe Gln Pro Val Leu Arg Arg Arg Val Met Asp Met Phe Asn 
705                 710                 715                 720 


Asn Gly Phe Leu Ser Ala Lys Thr Leu Thr Val Ala Leu Ser Glu Gly 
                725                 730                 735     


Ala Ala Ile Cys Ala Pro Ser Leu Thr Ala Gly Gln Thr Ala Pro Ala 
            740                 745                 750         


Glu Ser Ser Phe Glu Gly Asp Val Ala Arg Val Thr Leu Gly Phe Pro 
        755                 760                 765             


Lys Glu Leu Arg Val Lys Ser Arg Val Leu Phe Ala Gly Ala Ser Ala 
    770                 775                 780                 


Asn Ala Ser Glu Ala Ala Lys Ala Arg Val Ala Ser Leu Gln Ser Ala 
785                 790                 795                 800 


Tyr Gln Lys Pro Asp Lys Arg Val Asp Ile Leu Leu Gly Pro Leu Gly 
                805                 810                 815     


Phe Leu Leu Lys Gln Phe His Ala Ala Ile Phe Pro Asn Gly Lys Pro 
            820                 825                 830         


Pro Gly Ser Asn Gln Pro Asn Pro Gln Trp Phe Trp Thr Ala Leu Gln 
        835                 840                 845             


Arg Asn Gln Leu Pro Ala Arg Leu Leu Ser Arg Glu Asp Ile Glu Thr 
    850                 855                 860                 


Ile Ala Phe Ile Lys Lys Phe Ser Leu Asp Tyr Gly Ala Ile Asn Phe 
865                 870                 875                 880 


Ile Asn Leu Ala Pro Asn Asn Val Ser Glu Leu Ala Met Tyr Tyr Met 
                885                 890                 895     


Ala Asn Gln Ile Leu Arg Tyr Cys Asp His Ser Thr Tyr Phe Ile Asn 
            900                 905                 910         


Thr Leu Thr Ala Ile Ile Ala Gly Ser Arg Arg Pro Pro Ser Val Gln 
        915                 920                 925             


Ala Ala Ala Ala Trp Ser Ala Gln Gly Gly Ala Gly Leu Glu Ala Gly 
    930                 935                 940                 


Ala Arg Ala Leu Met Asp Ala Val Asp Ala His Pro Gly Ala Trp Thr 
945                 950                 955                 960 


Ser Met Phe Ala Ser Cys Asn Leu Leu Arg Pro Val Met Ala Ala Arg 
                965                 970                 975     


Pro Met Val Val Leu Gly Leu Ser Ile Ser Lys Tyr Tyr Gly Met Ala 
            980                 985                 990         


Gly Asn Asp Arg Val Phe Gln Ala  Gly Asn Trp Ala Ser  Leu Met Gly 
        995                 1000                 1005             


Gly Lys  Asn Ala Cys Pro Leu  Leu Ile Phe Asp Arg  Thr Arg Lys 
    1010                 1015                 1020             


Phe Val  Leu Ala Cys Pro Arg  Ala Gly Phe Val Cys  Ala Ala Ser 
    1025                 1030                 1035             


Asn Leu  Gly Gly Gly Ala His  Glu Ser Ser Leu Cys  Glu Gln Leu 
    1040                 1045                 1050             


Arg Gly  Ile Ile Ser Glu Gly  Gly Ala Ala Val Ala  Ser Ser Val 
    1055                 1060                 1065             


Phe Val  Ala Thr Val Lys Ser  Leu Gly Pro Arg Thr  Gln Gln Leu 
    1070                 1075                 1080             


Gln Ile  Glu Asp Trp Leu Ala  Leu Leu Glu Asp Glu  Tyr Leu Ser 
    1085                 1090                 1095             


Glu Glu  Met Met Glu Leu Thr  Ala Arg Ala Leu Glu  Arg Gly Asn 
    1100                 1105                 1110             


Gly Glu  Trp Ser Thr Asp Ala  Ala Leu Glu Val Ala  His Glu Ala 
    1115                 1120                 1125             


Glu Ala  Leu Val Ser Gln Leu  Gly Asn Ala Gly Glu  Val Phe Asn 
    1130                 1135                 1140             


Phe Gly  Asp Phe Gly Cys Glu  Asp Asp Asn Ala Thr  Pro Phe Gly 
    1145                 1150                 1155             


Gly Pro  Gly Ala Pro Gly Pro  Ala Phe Ala Gly Arg  Lys Arg Ala 
    1160                 1165                 1170             


Phe His  Gly Asp Asp Pro Phe  Gly Glu Gly Pro Pro  Asp Lys Lys 
    1175                 1180                 1185             


Gly Asp  Leu Thr Leu Asp Met  Leu 
    1190                 1195     


<210>  33
<211>  3591
<212>  DNA
<213>  Herpes simplex virus type 1

<400>  33
atggagacaa agcccaagac ggcaaccacc atcaaggtcc cccccgggcc cctgggatac       60

gtgtacgctc gcgcgtgtcc gtccgaaggc atcgagcttc tggcgttact gtcggcacgc      120

agcggcgatt ccgacgtcgc cgtggcgccc ctggtcgtgg gcctgaccgt ggagagcggc      180

tttgaggcca acgtggccgt ggtcgtgggt tctcgcacga cggggctcgg gggtaccgcg      240

gtgtccctga aactgacgcc ctcgcactac agctcgtccg tgtacgtctt tcacggcggc      300

cggcacctgg accccagcac ccaggccccg aacctgacgc gactttgcga gcgggcacgc      360

cgccattttg gcttttcgga ctacaccccc cggcccggcg acctcaaaca cgagacgacg      420

ggggaggcgc tgtgtgagcg cctcggcctg gacccggacc gcgccctcct gtatctggtc      480

gttaccgagg gcttcaagga ggccgtgtgc atcaacaaca cctttctgca cctgggaggc      540

tcggacaagg taaccatagg cggggcggag gtgcaccgca tacccgtgta cccgttgcag      600

ctgttcatgc cggattttag ccgtgtcatc gcagagccgt tcaacgccaa ccaccgatcg      660

atcggggaga attttaccta cccgcttccg ttttttaacc gccccctcaa ccgcctcctg      720

ttcgaggcgg tcgtgggacc cgccgccgtg gcactgcgat gccgaaacgt ggacgccgtg      780

gcccgcgcgg ccgcccacct ggcgtttgac gaaaaccacg agggcgccgc cctccccgcc      840

gacattacgt tcacggcctt cgaagccagc cagggtaaga ccccgcgggg cgggcgcgac      900

ggcggcggca agggcccggc gggcgggttc gaacagcgcc tggcctccgt catggccgga      960

gacgccgccc tggccctcga ttctatcgtg tcgatggccg tctttgacga gccgcccacc     1020

gacatctccg cgtggccgct gttcgagggc caggacacgg ccgcggcccg cgccaacgcc     1080

gtcggggcgt acctggcgcg cgccgcggga ctcgtggggg ccatggtatt tagcaccaac     1140

tcggccctcc atctcaccga ggtggacgac gccggcccgg cggacccaaa ggaccacagc     1200

aaaccctcct tttaccgctt cttcctcgtg cccgggaccc acgtggcggc caacccacag     1260

gtggaccgcg agggacacgt ggtgcccggg ttcgagggtc ggcccaccgc gcccctcgtc     1320

ggcggaaccc aggaatttgc cggcgagcac ctggccatgc tgtgtgggtt ttccccggcg     1380

ctgctggcca agatgctgtt ttacctggag cgctgcgacg gcggcgtgat cgtcgggcgc     1440

caggagatgg acgtgtttcg atacgtcgcg gactccaacc agaccgacgt gccctgtaac     1500

ctatgcacct tcgacacgcg ccacgcctgc gtacacacga cgctcatgcg cctccgggcg     1560

cgccatccaa agttcgccag cgccgcccgc ggagccatcg gcgtcttcgg gaccatgaac     1620

agcatgtaca gcgactgcga cgtgctggga aactacgccg ccttctcggc cctgaagcgc     1680

gcggacggat ccgagaccgc ccggaccatc atgcaggaga cgtaccgcgc ggcgaccgag     1740

cgcgtcatgg ccgaactcga gaccctgcag tacgtggacc aggcggtccc cacggccatg     1800

gggcggctgg agaccatcat caccaaccgc gaggccctgc atacggtggt gaacaacgtc     1860

aggcaggtcg tggaccgcga ggtggagcag ctgatgcgca acctggtgga ggggaggaac     1920

ttcaagtttc gcgacggtct gggcgaggcc aaccacgcca tgtccctgac gctggacccg     1980

tacgcgtgcg ggccgtgccc cctgcttcag cttctcgggc ggcgatccaa cctcgccgtg     2040

taccaggacc tggccctgag tcagtgccac ggggtgttcg ccgggcagtc ggtcgagggg     2100

cgcaactttc gcaatcaatt ccaaccggtg ctgcggcggc gcgtgatgga catgtttaac     2160

aacgggtttc tgtcggccaa aacgctgacg gtcgcgctct cggagggggc ggctatctgc     2220

gcccccagcc taacggccgg ccagacggcc cccgccgaga gcagcttcga gggcgacgtt     2280

gcccgcgtga ccctggggtt tcccaaggag ctgcgcgtca agagccgcgt gttgttcgcg     2340

ggcgcgagcg ccaacgcgtc cgaggccgcc aaggcgcggg tcgccagcct ccagagcgcc     2400

taccagaagc ccgacaagcg cgtggacatc ctcctcggac cgctgggctt tctgctgaag     2460

cagttccacg cggccatctt ccccaacggc aagcccccgg ggtccaacca gccgaacccg     2520

cagtggttct ggacggccct ccaacgcaac cagcttcccg cccggctcct gtcgcgcgag     2580

gacatcgaga ccatcgcgtt cattaaaaag ttttccctgg actacggcgc gataaacttt     2640

attaacctgg cccccaacaa cgtgagcgag ctggcgatgt actacatggc aaaccagatt     2700

ctgcggtact gcgatcactc gacatacttc atcaacaccc ttacggccat catcgcgggg     2760

tcccgccgtc cccccagcgt gcaggctgcg gccgcgtggt ccgcgcaggg cggggcgggc     2820

ctggaggccg gggcccgcgc gctgatggac gccgtggacg cgcatccggg cgcgtggacg     2880

tccatgttcg ccagctgcaa cctgctgcgg cccgtcatgg cggcgcgccc catggtcgtg     2940

ttggggttga gcatcagcaa gtactacggc atggccggca acgaccgtgt gtttcaggcc     3000

gggaactggg ccagcctgat gggcggcaaa aacgcgtgcc cgctccttat ttttgaccgc     3060

acccgcaagt tcgtcctggc ctgtccccgg gccgggtttg tgtgcgcggc ctcaagcctc     3120

ggcggcggag cgcacgaaag ctcgctgtgc gagcagctcc ggggcattat ctccgagggc     3180

ggggcggccg tcgccagtag cgtgttcgtg gcgaccgtga aaagcctggg gccccgcacc     3240

cagcagctgc agatcgagga ctggctggcg ctcctggagg acgagtacct aagcgaggag     3300

atgatggagc tgaccgcgcg tgccctggag cgcggcaacg gcgagtggtc gacggacgcg     3360

gccctggagg tggcgcacga ggccgaggcc ctagtcagcc aactcggcaa cgccggggag     3420

gtgtttaact ttggggattt tggctgcgag gacgacaacg cgacgccgtt cggcggcccg     3480

ggggccccgg gaccggcatt tgccggccgc aaacgggcgt tccacgggga tgacccgttt     3540

ggggaggggc cccccgacaa aaagggagac ctgacgttgg atatgctgtg a              3591


<210>  34
<211>  1196
<212>  PRT
<213>  Herpes simplex virus type 1

<400>  34

Met Glu Thr Lys Pro Lys Thr Ala Thr Thr Ile Lys Val Pro Pro Gly 
1               5                   10                  15      


Pro Leu Gly Tyr Val Tyr Ala Arg Ala Cys Pro Ser Glu Gly Ile Glu 
            20                  25                  30          


Leu Leu Ala Leu Leu Ser Ala Arg Ser Gly Asp Ser Asp Val Ala Val 
        35                  40                  45              


Ala Pro Leu Val Val Gly Leu Thr Val Glu Ser Gly Phe Glu Ala Asn 
    50                  55                  60                  


Val Ala Val Val Val Gly Ser Arg Thr Thr Gly Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Val Ser Leu Lys Leu Thr Pro Ser His Tyr Ser Ser Ser Val Tyr Val 
                85                  90                  95      


Phe His Gly Gly Arg His Leu Asp Pro Ser Thr Gln Ala Pro Asn Leu 
            100                 105                 110         


Thr Arg Leu Cys Glu Arg Ala Arg Arg His Phe Gly Phe Ser Asp Tyr 
        115                 120                 125             


Thr Pro Arg Pro Gly Asp Leu Lys His Glu Thr Thr Gly Glu Ala Leu 
    130                 135                 140                 


Cys Glu Arg Leu Gly Leu Asp Pro Asp Arg Ala Leu Leu Tyr Leu Val 
145                 150                 155                 160 


Val Thr Glu Gly Phe Lys Glu Ala Val Cys Ile Asn Asn Thr Phe Leu 
                165                 170                 175     


His Leu Gly Gly Ser Asp Lys Val Thr Ile Gly Gly Ala Glu Val His 
            180                 185                 190         


Arg Ile Pro Val Tyr Pro Leu Gln Leu Phe Met Pro Asp Phe Ser Arg 
        195                 200                 205             


Val Ile Ala Glu Pro Phe Asn Ala Asn His Arg Ser Ile Gly Glu Asn 
    210                 215                 220                 


Phe Thr Tyr Pro Leu Pro Phe Phe Asn Arg Pro Leu Asn Arg Leu Leu 
225                 230                 235                 240 


Phe Glu Ala Val Val Gly Pro Ala Ala Val Ala Leu Arg Cys Arg Asn 
                245                 250                 255     


Val Asp Ala Val Ala Arg Ala Ala Ala His Leu Ala Phe Asp Glu Asn 
            260                 265                 270         


His Glu Gly Ala Ala Leu Pro Ala Asp Ile Thr Phe Thr Ala Phe Glu 
        275                 280                 285             


Ala Ser Gln Gly Lys Thr Pro Arg Gly Gly Arg Asp Gly Gly Gly Lys 
    290                 295                 300                 


Gly Pro Ala Gly Gly Phe Glu Gln Arg Leu Ala Ser Val Met Ala Gly 
305                 310                 315                 320 


Asp Ala Ala Leu Ala Leu Asp Ser Ile Val Ser Met Ala Val Phe Asp 
                325                 330                 335     


Glu Pro Pro Thr Asp Ile Ser Ala Trp Pro Leu Phe Glu Gly Gln Asp 
            340                 345                 350         


Thr Ala Ala Ala Arg Ala Asn Ala Val Gly Ala Tyr Leu Ala Arg Ala 
        355                 360                 365             


Ala Gly Leu Val Gly Ala Met Val Phe Ser Thr Asn Ser Ala Leu His 
    370                 375                 380                 


Leu Thr Glu Val Asp Asp Ala Gly Pro Ala Asp Pro Lys Asp His Ser 
385                 390                 395                 400 


Lys Pro Ser Phe Tyr Arg Phe Phe Leu Val Pro Gly Thr His Val Ala 
                405                 410                 415     


Ala Asn Pro Gln Val Asp Arg Glu Gly His Val Val Pro Gly Phe Glu 
            420                 425                 430         


Gly Arg Pro Thr Ala Pro Leu Val Gly Gly Thr Gln Glu Phe Ala Gly 
        435                 440                 445             


Glu His Leu Ala Met Leu Cys Gly Phe Ser Pro Ala Leu Leu Ala Lys 
    450                 455                 460                 


Met Leu Phe Tyr Leu Glu Arg Cys Asp Gly Gly Val Ile Val Gly Arg 
465                 470                 475                 480 


Gln Glu Met Asp Val Phe Arg Tyr Val Ala Asp Ser Asn Gln Thr Asp 
                485                 490                 495     


Val Pro Cys Asn Leu Cys Thr Phe Asp Thr Arg His Ala Cys Val His 
            500                 505                 510         


Thr Thr Leu Met Arg Leu Arg Ala Arg His Pro Lys Phe Ala Ser Ala 
        515                 520                 525             


Ala Arg Gly Ala Ile Gly Val Phe Gly Thr Met Asn Ser Met Tyr Ser 
    530                 535                 540                 


Asp Cys Asp Val Leu Gly Asn Tyr Ala Ala Phe Ser Ala Leu Lys Arg 
545                 550                 555                 560 


Ala Asp Gly Ser Glu Thr Ala Arg Thr Ile Met Gln Glu Thr Tyr Arg 
                565                 570                 575     


Ala Ala Thr Glu Arg Val Met Ala Glu Leu Glu Thr Leu Gln Tyr Val 
            580                 585                 590         


Asp Gln Ala Val Pro Thr Ala Met Gly Arg Leu Glu Thr Ile Ile Thr 
        595                 600                 605             


Asn Arg Glu Ala Leu His Thr Val Val Asn Asn Val Arg Gln Val Val 
    610                 615                 620                 


Asp Arg Glu Val Glu Gln Leu Met Arg Asn Leu Val Glu Gly Arg Asn 
625                 630                 635                 640 


Phe Lys Phe Arg Asp Gly Leu Gly Glu Ala Asn His Ala Met Ser Leu 
                645                 650                 655     


Thr Leu Asp Pro Tyr Ala Cys Gly Pro Cys Pro Leu Leu Gln Leu Leu 
            660                 665                 670         


Gly Arg Arg Ser Asn Leu Ala Val Tyr Gln Asp Leu Ala Leu Ser Gln 
        675                 680                 685             


Cys His Gly Val Phe Ala Gly Gln Ser Val Glu Gly Arg Asn Phe Arg 
    690                 695                 700                 


Asn Gln Phe Gln Pro Val Leu Arg Arg Arg Val Met Asp Met Phe Asn 
705                 710                 715                 720 


Asn Gly Phe Leu Ser Ala Lys Thr Leu Thr Val Ala Leu Ser Glu Gly 
                725                 730                 735     


Ala Ala Ile Cys Ala Pro Ser Leu Thr Ala Gly Gln Thr Ala Pro Ala 
            740                 745                 750         


Glu Ser Ser Phe Glu Gly Asp Val Ala Arg Val Thr Leu Gly Phe Pro 
        755                 760                 765             


Lys Glu Leu Arg Val Lys Ser Arg Val Leu Phe Ala Gly Ala Ser Ala 
    770                 775                 780                 


Asn Ala Ser Glu Ala Ala Lys Ala Arg Val Ala Ser Leu Gln Ser Ala 
785                 790                 795                 800 


Tyr Gln Lys Pro Asp Lys Arg Val Asp Ile Leu Leu Gly Pro Leu Gly 
                805                 810                 815     


Phe Leu Leu Lys Gln Phe His Ala Ala Ile Phe Pro Asn Gly Lys Pro 
            820                 825                 830         


Pro Gly Ser Asn Gln Pro Asn Pro Gln Trp Phe Trp Thr Ala Leu Gln 
        835                 840                 845             


Arg Asn Gln Leu Pro Ala Arg Leu Leu Ser Arg Glu Asp Ile Glu Thr 
    850                 855                 860                 


Ile Ala Phe Ile Lys Lys Phe Ser Leu Asp Tyr Gly Ala Ile Asn Phe 
865                 870                 875                 880 


Ile Asn Leu Ala Pro Asn Asn Val Ser Glu Leu Ala Met Tyr Tyr Met 
                885                 890                 895     


Ala Asn Gln Ile Leu Arg Tyr Cys Asp His Ser Thr Tyr Phe Ile Asn 
            900                 905                 910         


Thr Leu Thr Ala Ile Ile Ala Gly Ser Arg Arg Pro Pro Ser Val Gln 
        915                 920                 925             


Ala Ala Ala Ala Trp Ser Ala Gln Gly Gly Ala Gly Leu Glu Ala Gly 
    930                 935                 940                 


Ala Arg Ala Leu Met Asp Ala Val Asp Ala His Pro Gly Ala Trp Thr 
945                 950                 955                 960 


Ser Met Phe Ala Ser Cys Asn Leu Leu Arg Pro Val Met Ala Ala Arg 
                965                 970                 975     


Pro Met Val Val Leu Gly Leu Ser Ile Ser Lys Tyr Tyr Gly Met Ala 
            980                 985                 990         


Gly Asn Asp Arg Val Phe Gln Ala  Gly Asn Trp Ala Ser  Leu Met Gly 
        995                 1000                 1005             


Gly Lys  Asn Ala Cys Pro Leu  Leu Ile Phe Asp Arg  Thr Arg Lys 
    1010                 1015                 1020             


Phe Val  Leu Ala Cys Pro Arg  Ala Gly Phe Val Cys  Ala Ala Ser 
    1025                 1030                 1035             


Ser Leu  Gly Gly Gly Ala His  Glu Ser Ser Leu Cys  Glu Gln Leu 
    1040                 1045                 1050             


Arg Gly  Ile Ile Ser Glu Gly  Gly Ala Ala Val Ala  Ser Ser Val 
    1055                 1060                 1065             


Phe Val  Ala Thr Val Lys Ser  Leu Gly Pro Arg Thr  Gln Gln Leu 
    1070                 1075                 1080             


Gln Ile  Glu Asp Trp Leu Ala  Leu Leu Glu Asp Glu  Tyr Leu Ser 
    1085                 1090                 1095             


Glu Glu  Met Met Glu Leu Thr  Ala Arg Ala Leu Glu  Arg Gly Asn 
    1100                 1105                 1110             


Gly Glu  Trp Ser Thr Asp Ala  Ala Leu Glu Val Ala  His Glu Ala 
    1115                 1120                 1125             


Glu Ala  Leu Val Ser Gln Leu  Gly Asn Ala Gly Glu  Val Phe Asn 
    1130                 1135                 1140             


Phe Gly  Asp Phe Gly Cys Glu  Asp Asp Asn Ala Thr  Pro Phe Gly 
    1145                 1150                 1155             


Gly Pro  Gly Ala Pro Gly Pro  Ala Phe Ala Gly Arg  Lys Arg Ala 
    1160                 1165                 1170             


Phe His  Gly Asp Asp Pro Phe  Gly Glu Gly Pro Pro  Asp Lys Lys 
    1175                 1180                 1185             


Gly Asp  Leu Thr Leu Asp Met  Leu 
    1190                 1195     


<210>  35
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  mutation
<222>  (1126)..(1126)
<223>  g1126a

<400>  35
atgtttggtc agcagctggc gtccgacgtc cagcagtacc tggagcgcct cgagaaacag       60

aggcaactta aggtgggcgc ggacgaggcg tcggcgggcc tcaccatggg cggcgatgcc      120

ctacgagtgc cctttttaga tttcgcgacc gcgaccccca agcgccacca gaccgtggtc      180

cctggcgtcg ggacgctcca cgactgctgc gagcactcgc cgctcttctc ggccgtggcg      240

cggcggctgc tgtttaatag cctggtgccg gcgcaactaa aggggcgtga tttcgggggc      300

gaccacacgg ccaagctgga attcctggcc cccgagttgg tacgggcggt ggcgcgactg      360

cggtttaagg agtgcgcgcc ggcggacgtg gtgcctcagc gtaacgccta ctatagcgtt      420

ctgaatacgt ttcaggccct ccaccgctcc gaagcctttc gccagctggt gcactttgtg      480

cgggactttg cccagctgct caaaacctcc ttccgggcct ccagcctcac ggagaccacg      540

ggccccccca aaaaacgggc caaggtggac gtggccaccc acggccggac gtacggcacg      600

ctggagctgt tccaaaaaat gatccttatg cacgccacct actttctggc cgccgtgctc      660

ctcggggacc acgcggagca ggtcaacacg ttcctgcgtc tcgtgtttga gatccccctg      720

tttagcgacg cggccgtgcg ccacttccgc cagcgcgcca ccgtgtttct cgtcccccgg      780

cgccacggca agacctggtt tctggtgccc ctcatcgcgc tgtcgctggc ctcctttcgg      840

gggatcaaga tcggctacac ggcgcacatc cgcaaggcga ccgagccggt gtttgaggag      900

atcgacgcct gcctgcgggg ctggttcggt tcggcccgag tggaccacgt taaaggggaa      960

accatctcct tctcgtttcc ggacgggtcg cgcagtacca tcgtgtttgc ctccagccac     1020

aacacaaacg gaatccgagg ccaggacttt aacctgctct ttgtcgacga ggccaacttt     1080

attcgcccgg atgcggtcca gacgattatg ggctttctca accagaccaa ctgcaagatt     1140

atcttcgtgt cgtccaccaa caccgggaag gccagtacga gctttttgta caacctccgc     1200

ggggccgcag acgagcttct caacgtggtg acctatatat gcgatgatca catgccgagg     1260

gtggtgacgc acacaaacgc cacggcctgt tcttgttata tcctcaacaa gcccgttttc     1320

atcacgatgg acggggcggt tcgccggacc gccgatttgt ttctggccga ttccttcatg     1380

caggagatca tcgggggcca ggccagggag accggcgacg accggcccgt tctgaccaag     1440

tctgcggggg agcggtttct gttgtaccgc ccctcgacca ccaccaacag cggcctcatg     1500

gcccccgatt tgtacgtgta cgtggatccc gcgttcacgg ccaacacccg agcctccggg     1560

accggcgtcg ctgtcgtcgg gcggtaccgc gacgattata tcatcttcgc cctggagcac     1620

ttttttctcc gcgcgctcac gggctcggcc cccgccgaca tcgcccgctg cgtcgtccac     1680

agtctgacgc aggtcctggc cctgcatccc ggggcgtttc gcggcgtccg ggtggcggtc     1740

gagggaaata gcagccagga ctcggccgtc gccatcgcca cgcacgtgca cacagagatg     1800

caccgcctac tggcctcgga gggggccgac gcgggctcgg gccccgagct tctcttctac     1860

cactgcgagc ctcccgggag cgcggtgctg tacccctttt tcctgctcaa caaacagaag     1920

acgcccgcct ttgaacactt tattaaaaag tttaactccg ggggcgtcat ggcctcccag     1980

gagatcgttt ccgcgacggt gcgcctgcag accgacccgg tcgagtatct gctcgagcag     2040

ctaaataacc tcaccgaaac cgtctccccc aacactgacg tccgtacgta ttccggaaaa     2100

cggaacggcg cctcggatga ccttatggtc gccgtcatta tggccatcta cctcgcggcc     2160

caggccggac ctccgcacac attcgctcct atcatacgcg tctcgtga                  2208


<210>  36
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (376)..(376)
<223>  A376T

<400>  36

Met Phe Gly Gln Gln Leu Ala Ser Asp Val Gln Gln Tyr Leu Glu Arg 
1               5                   10                  15      


Leu Glu Lys Gln Arg Gln Leu Lys Val Gly Ala Asp Glu Ala Ser Ala 
            20                  25                  30          


Gly Leu Thr Met Gly Gly Asp Ala Leu Arg Val Pro Phe Leu Asp Phe 
        35                  40                  45              


Ala Thr Ala Thr Pro Lys Arg His Gln Thr Val Val Pro Gly Val Gly 
    50                  55                  60                  


Thr Leu His Asp Cys Cys Glu His Ser Pro Leu Phe Ser Ala Val Ala 
65                  70                  75                  80  


Arg Arg Leu Leu Phe Asn Ser Leu Val Pro Ala Gln Leu Lys Gly Arg 
                85                  90                  95      


Asp Phe Gly Gly Asp His Thr Ala Lys Leu Glu Phe Leu Ala Pro Glu 
            100                 105                 110         


Leu Val Arg Ala Val Ala Arg Leu Arg Phe Lys Glu Cys Ala Pro Ala 
        115                 120                 125             


Asp Val Val Pro Gln Arg Asn Ala Tyr Tyr Ser Val Leu Asn Thr Phe 
    130                 135                 140                 


Gln Ala Leu His Arg Ser Glu Ala Phe Arg Gln Leu Val His Phe Val 
145                 150                 155                 160 


Arg Asp Phe Ala Gln Leu Leu Lys Thr Ser Phe Arg Ala Ser Ser Leu 
                165                 170                 175     


Thr Glu Thr Thr Gly Pro Pro Lys Lys Arg Ala Lys Val Asp Val Ala 
            180                 185                 190         


Thr His Gly Arg Thr Tyr Gly Thr Leu Glu Leu Phe Gln Lys Met Ile 
        195                 200                 205             


Leu Met His Ala Thr Tyr Phe Leu Ala Ala Val Leu Leu Gly Asp His 
    210                 215                 220                 


Ala Glu Gln Val Asn Thr Phe Leu Arg Leu Val Phe Glu Ile Pro Leu 
225                 230                 235                 240 


Phe Ser Asp Ala Ala Val Arg His Phe Arg Gln Arg Ala Thr Val Phe 
                245                 250                 255     


Leu Val Pro Arg Arg His Gly Lys Thr Trp Phe Leu Val Pro Leu Ile 
            260                 265                 270         


Ala Leu Ser Leu Ala Ser Phe Arg Gly Ile Lys Ile Gly Tyr Thr Ala 
        275                 280                 285             


His Ile Arg Lys Ala Thr Glu Pro Val Phe Glu Glu Ile Asp Ala Cys 
    290                 295                 300                 


Leu Arg Gly Trp Phe Gly Ser Ala Arg Val Asp His Val Lys Gly Glu 
305                 310                 315                 320 


Thr Ile Ser Phe Ser Phe Pro Asp Gly Ser Arg Ser Thr Ile Val Phe 
                325                 330                 335     


Ala Ser Ser His Asn Thr Asn Gly Ile Arg Gly Gln Asp Phe Asn Leu 
            340                 345                 350         


Leu Phe Val Asp Glu Ala Asn Phe Ile Arg Pro Asp Ala Val Gln Thr 
        355                 360                 365             


Ile Met Gly Phe Leu Asn Gln Thr Asn Cys Lys Ile Ile Phe Val Ser 
    370                 375                 380                 


Ser Thr Asn Thr Gly Lys Ala Ser Thr Ser Phe Leu Tyr Asn Leu Arg 
385                 390                 395                 400 


Gly Ala Ala Asp Glu Leu Leu Asn Val Val Thr Tyr Ile Cys Asp Asp 
                405                 410                 415     


His Met Pro Arg Val Val Thr His Thr Asn Ala Thr Ala Cys Ser Cys 
            420                 425                 430         


Tyr Ile Leu Asn Lys Pro Val Phe Ile Thr Met Asp Gly Ala Val Arg 
        435                 440                 445             


Arg Thr Ala Asp Leu Phe Leu Ala Asp Ser Phe Met Gln Glu Ile Ile 
    450                 455                 460                 


Gly Gly Gln Ala Arg Glu Thr Gly Asp Asp Arg Pro Val Leu Thr Lys 
465                 470                 475                 480 


Ser Ala Gly Glu Arg Phe Leu Leu Tyr Arg Pro Ser Thr Thr Thr Asn 
                485                 490                 495     


Ser Gly Leu Met Ala Pro Asp Leu Tyr Val Tyr Val Asp Pro Ala Phe 
            500                 505                 510         


Thr Ala Asn Thr Arg Ala Ser Gly Thr Gly Val Ala Val Val Gly Arg 
        515                 520                 525             


Tyr Arg Asp Asp Tyr Ile Ile Phe Ala Leu Glu His Phe Phe Leu Arg 
    530                 535                 540                 


Ala Leu Thr Gly Ser Ala Pro Ala Asp Ile Ala Arg Cys Val Val His 
545                 550                 555                 560 


Ser Leu Thr Gln Val Leu Ala Leu His Pro Gly Ala Phe Arg Gly Val 
                565                 570                 575     


Arg Val Ala Val Glu Gly Asn Ser Ser Gln Asp Ser Ala Val Ala Ile 
            580                 585                 590         


Ala Thr His Val His Thr Glu Met His Arg Leu Leu Ala Ser Glu Gly 
        595                 600                 605             


Ala Asp Ala Gly Ser Gly Pro Glu Leu Leu Phe Tyr His Cys Glu Pro 
    610                 615                 620                 


Pro Gly Ser Ala Val Leu Tyr Pro Phe Phe Leu Leu Asn Lys Gln Lys 
625                 630                 635                 640 


Thr Pro Ala Phe Glu His Phe Ile Lys Lys Phe Asn Ser Gly Gly Val 
                645                 650                 655     


Met Ala Ser Gln Glu Ile Val Ser Ala Thr Val Arg Leu Gln Thr Asp 
            660                 665                 670         


Pro Val Glu Tyr Leu Leu Glu Gln Leu Asn Asn Leu Thr Glu Thr Val 
        675                 680                 685             


Ser Pro Asn Thr Asp Val Arg Thr Tyr Ser Gly Lys Arg Asn Gly Ala 
    690                 695                 700                 


Ser Asp Asp Leu Met Val Ala Val Ile Met Ala Ile Tyr Leu Ala Ala 
705                 710                 715                 720 


Gln Ala Gly Pro Pro His Thr Phe Ala Pro Ile Ile Arg Val Ser 
                725                 730                 735 


<210>  37
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  37
atgtttggtc agcagctggc gtccgacgtc cagcagtacc tggagcgcct cgagaaacag       60

aggcaactta aggtgggcgc ggacgaggcg tcggcgggcc tcaccatggg cggcgatgcc      120

ctacgagtgc cctttttaga tttcgcgacc gcgaccccca agcgccacca gaccgtggtc      180

cctggcgtcg ggacgctcca cgactgctgc gagcactcgc cgctcttctc ggccgtggcg      240

cggcggctgc tgtttaatag cctggtgccg gcgcaactaa aggggcgtga tttcgggggc      300

gaccacacgg ccaagctgga attcctggcc cccgagttgg tacgggcggt ggcgcgactg      360

cggtttaagg agtgcgcgcc ggcggacgtg gtgcctcagc gtaacgccta ctatagcgtt      420

ctgaatacgt ttcaggccct ccaccgctcc gaagcctttc gccagctggt gcactttgtg      480

cgggactttg cccagctgct caaaacctcc ttccgggcct ccagcctcac ggagaccacg      540

ggccccccca aaaaacgggc caaggtggac gtggccaccc acggccggac gtacggcacg      600

ctggagctgt tccaaaaaat gatccttatg cacgccacct actttctggc cgccgtgctc      660

ctcggggacc acgcggagca ggtcaacacg ttcctgcgtc tcgtgtttga gatccccctg      720

tttagcgacg cggccgtgcg ccacttccgc cagcgcgcca ccgtgtttct cgtcccccgg      780

cgccacggca agacctggtt tctggtgccc ctcatcgcgc tgtcgctggc ctcctttcgg      840

gggatcaaga tcggctacac ggcgcacatc cgcaaggcga ccgagccggt gtttgaggag      900

atcgacgcct gcctgcgggg ctggttcggt tcggcccgag tggaccacgt taaaggggaa      960

accatctcct tctcgtttcc ggacgggtcg cgcagtacca tcgtgtttgc ctccagccac     1020

aacacaaacg gaatccgagg ccaggacttt aacctgctct ttgtcgacga ggccaacttt     1080

attcgcccgg atgcggtcca gacgattatg ggctttctca accaggccaa ctgcaagatt     1140

atcttcgtgt cgtccaccaa caccgggaag gccagtacga gctttttgta caacctccgc     1200

ggggccgcag acgagcttct caacgtggtg acctatatat gcgatgatca catgccgagg     1260

gtggtgacgc acacaaacgc cacggcctgt tcttgttata tcctcaacaa gcccgttttc     1320

atcacgatgg acggggcggt tcgccggacc gccgatttgt ttctggccga ttccttcatg     1380

caggagatca tcgggggcca ggccagggag accggcgacg accggcccgt tctgaccaag     1440

tctgcggggg agcggtttct gttgtaccgc ccctcgacca ccaccaacag cggcctcatg     1500

gcccccgatt tgtacgtgta cgtggatccc gcgttcacgg ccaacacccg agcctccggg     1560

accggcgtcg ctgtcgtcgg gcggtaccgc gacgattata tcatcttcgc cctggagcac     1620

ttttttctcc gcgcgctcac gggctcggcc cccgccgaca tcgcccgctg cgtcgtccac     1680

agtctgacgc aggtcctggc cctgcatccc ggggcgtttc gcggcgtccg ggtggcggtc     1740

gagggaaata gcagccagga ctcggccgtc gccatcgcca cgcacgtgca cacagagatg     1800

caccgcctac tggcctcgga gggggccgac gcgggctcgg gccccgagct tctcttctac     1860

cactgcgagc ctcccgggag cgcggtgctg tacccctttt tcctgctcaa caaacagaag     1920

acgcccgcct ttgaacactt tattaaaaag tttaactccg ggggcgtcat ggcctcccag     1980

gagatcgttt ccgcgacggt gcgcctgcag accgacccgg tcgagtatct gctcgagcag     2040

ctaaataacc tcaccgaaac cgtctccccc aacactgacg tccgtacgta ttccggaaaa     2100

cggaacggcg cctcggatga ccttatggtc gccgtcatta tggccatcta cctcgcggcc     2160

caggccggac ctccgcacac attcgctcct atcatacgcg tctcgtga                  2208


<210>  38
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  38

Met Phe Gly Gln Gln Leu Ala Ser Asp Val Gln Gln Tyr Leu Glu Arg 
1               5                   10                  15      


Leu Glu Lys Gln Arg Gln Leu Lys Val Gly Ala Asp Glu Ala Ser Ala 
            20                  25                  30          


Gly Leu Thr Met Gly Gly Asp Ala Leu Arg Val Pro Phe Leu Asp Phe 
        35                  40                  45              


Ala Thr Ala Thr Pro Lys Arg His Gln Thr Val Val Pro Gly Val Gly 
    50                  55                  60                  


Thr Leu His Asp Cys Cys Glu His Ser Pro Leu Phe Ser Ala Val Ala 
65                  70                  75                  80  


Arg Arg Leu Leu Phe Asn Ser Leu Val Pro Ala Gln Leu Lys Gly Arg 
                85                  90                  95      


Asp Phe Gly Gly Asp His Thr Ala Lys Leu Glu Phe Leu Ala Pro Glu 
            100                 105                 110         


Leu Val Arg Ala Val Ala Arg Leu Arg Phe Lys Glu Cys Ala Pro Ala 
        115                 120                 125             


Asp Val Val Pro Gln Arg Asn Ala Tyr Tyr Ser Val Leu Asn Thr Phe 
    130                 135                 140                 


Gln Ala Leu His Arg Ser Glu Ala Phe Arg Gln Leu Val His Phe Val 
145                 150                 155                 160 


Arg Asp Phe Ala Gln Leu Leu Lys Thr Ser Phe Arg Ala Ser Ser Leu 
                165                 170                 175     


Thr Glu Thr Thr Gly Pro Pro Lys Lys Arg Ala Lys Val Asp Val Ala 
            180                 185                 190         


Thr His Gly Arg Thr Tyr Gly Thr Leu Glu Leu Phe Gln Lys Met Ile 
        195                 200                 205             


Leu Met His Ala Thr Tyr Phe Leu Ala Ala Val Leu Leu Gly Asp His 
    210                 215                 220                 


Ala Glu Gln Val Asn Thr Phe Leu Arg Leu Val Phe Glu Ile Pro Leu 
225                 230                 235                 240 


Phe Ser Asp Ala Ala Val Arg His Phe Arg Gln Arg Ala Thr Val Phe 
                245                 250                 255     


Leu Val Pro Arg Arg His Gly Lys Thr Trp Phe Leu Val Pro Leu Ile 
            260                 265                 270         


Ala Leu Ser Leu Ala Ser Phe Arg Gly Ile Lys Ile Gly Tyr Thr Ala 
        275                 280                 285             


His Ile Arg Lys Ala Thr Glu Pro Val Phe Glu Glu Ile Asp Ala Cys 
    290                 295                 300                 


Leu Arg Gly Trp Phe Gly Ser Ala Arg Val Asp His Val Lys Gly Glu 
305                 310                 315                 320 


Thr Ile Ser Phe Ser Phe Pro Asp Gly Ser Arg Ser Thr Ile Val Phe 
                325                 330                 335     


Ala Ser Ser His Asn Thr Asn Gly Ile Arg Gly Gln Asp Phe Asn Leu 
            340                 345                 350         


Leu Phe Val Asp Glu Ala Asn Phe Ile Arg Pro Asp Ala Val Gln Thr 
        355                 360                 365             


Ile Met Gly Phe Leu Asn Gln Ala Asn Cys Lys Ile Ile Phe Val Ser 
    370                 375                 380                 


Ser Thr Asn Thr Gly Lys Ala Ser Thr Ser Phe Leu Tyr Asn Leu Arg 
385                 390                 395                 400 


Gly Ala Ala Asp Glu Leu Leu Asn Val Val Thr Tyr Ile Cys Asp Asp 
                405                 410                 415     


His Met Pro Arg Val Val Thr His Thr Asn Ala Thr Ala Cys Ser Cys 
            420                 425                 430         


Tyr Ile Leu Asn Lys Pro Val Phe Ile Thr Met Asp Gly Ala Val Arg 
        435                 440                 445             


Arg Thr Ala Asp Leu Phe Leu Ala Asp Ser Phe Met Gln Glu Ile Ile 
    450                 455                 460                 


Gly Gly Gln Ala Arg Glu Thr Gly Asp Asp Arg Pro Val Leu Thr Lys 
465                 470                 475                 480 


Ser Ala Gly Glu Arg Phe Leu Leu Tyr Arg Pro Ser Thr Thr Thr Asn 
                485                 490                 495     


Ser Gly Leu Met Ala Pro Asp Leu Tyr Val Tyr Val Asp Pro Ala Phe 
            500                 505                 510         


Thr Ala Asn Thr Arg Ala Ser Gly Thr Gly Val Ala Val Val Gly Arg 
        515                 520                 525             


Tyr Arg Asp Asp Tyr Ile Ile Phe Ala Leu Glu His Phe Phe Leu Arg 
    530                 535                 540                 


Ala Leu Thr Gly Ser Ala Pro Ala Asp Ile Ala Arg Cys Val Val His 
545                 550                 555                 560 


Ser Leu Thr Gln Val Leu Ala Leu His Pro Gly Ala Phe Arg Gly Val 
                565                 570                 575     


Arg Val Ala Val Glu Gly Asn Ser Ser Gln Asp Ser Ala Val Ala Ile 
            580                 585                 590         


Ala Thr His Val His Thr Glu Met His Arg Leu Leu Ala Ser Glu Gly 
        595                 600                 605             


Ala Asp Ala Gly Ser Gly Pro Glu Leu Leu Phe Tyr His Cys Glu Pro 
    610                 615                 620                 


Pro Gly Ser Ala Val Leu Tyr Pro Phe Phe Leu Leu Asn Lys Gln Lys 
625                 630                 635                 640 


Thr Pro Ala Phe Glu His Phe Ile Lys Lys Phe Asn Ser Gly Gly Val 
                645                 650                 655     


Met Ala Ser Gln Glu Ile Val Ser Ala Thr Val Arg Leu Gln Thr Asp 
            660                 665                 670         


Pro Val Glu Tyr Leu Leu Glu Gln Leu Asn Asn Leu Thr Glu Thr Val 
        675                 680                 685             


Ser Pro Asn Thr Asp Val Arg Thr Tyr Ser Gly Lys Arg Asn Gly Ala 
    690                 695                 700                 


Ser Asp Asp Leu Met Val Ala Val Ile Met Ala Ile Tyr Leu Ala Ala 
705                 710                 715                 720 


Gln Ala Gly Pro Pro His Thr Phe Ala Pro Ile Ile Arg Val Ser 
                725                 730                 735 


<210>  39
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  39
atgtttggtc agcagctggc gtccgacgtc cagcagtacc tggagcgcct cgagaaacag       60

aggcaactta aggtgggcgc ggacgaggcg tcggcgggcc tcacaatggg cggcgatgcc      120

ctacgagtgc cctttttaga tttcgcgacc gcgaccccca agcgccacca gaccgtggtc      180

ccgggcgtcg ggacgctcca cgactgctgc gagcactcgc cgctcttctc ggccgtggcg      240

cggcggctgc tgtttaatag cctggtgccg gcgcaactaa aggggcgtga tttcgggggc      300

gaccacacgg ccaagctgga attcctggcc cccgagttgg tacgggcggt ggcgcgactg      360

cggtttaagg agtgcgcgcc ggcggacgtg gtgcctcagc gtaacgccta ctatagcgtt      420

ctgaacacgt ttcaggccct ccaccgctcc gaagcctttc gccagctggt gcactttgtg      480

cgggactttg cccagctgct taaaacctcc ttccgggcct ccagcctcac ggagaccacg      540

ggccccccaa aaaaacgggc caaggtggac gtggccaccc acggccggac gtacggcacg      600

ctggagctgt tccaaaaaat gatccttatg cacgccacct actttctggc cgccgtgctc      660

ctcggggacc acgcggagca ggtcaacacg ttcctgcgtc tcgtgtttga gatccccctg      720

tttagcgacg cggccgtgcg ccacttccgc cagcgcgcca ccgtgtttct cgtcccccgg      780

cgccacggca agacctggtt tctagtgccc ctcatcgcgc tgtcgctggc ctcctttcgg      840

gggatcaaga tcggctacac ggcgcacatc cgcaaggcga ccgagccggt gtttgaggag      900

atcgacgcct gcctgcgggg ctggttcggt tcggcccgag tggaccacgt taaaggggaa      960

accatctcct tctcgtttcc ggacgggtcg cgcagtacca tcgtgtttgc ctccagccac     1020

aacacaaacg gaatccgagg ccaggacttt aacctgctct ttgtcgacga ggccaacttt     1080

attcgcccgg atgcggtcca gacgattatg ggctttctca accaggccaa ctgcaagatt     1140

atcttcgtgt cgtccaccaa caccgggaag gccagtacga gctttttgta caacctccgc     1200

ggggccgccg acgagcttct caacgtggtg acctatatat gcgatgatca catgccgcgg     1260

gtggtgacgc acacaaacgc cacggcctgt tcttgttata tcctcaacaa gcccgttttc     1320

atcacgatgg acggggcggt tcgccggacc gccgatttgt ttctggccga ttccttcatg     1380

caggagatca tcgggggcca ggccagggag accggcgacg accggcccgt tctgaccaag     1440

tctgcggggg agcggtttct gttgtaccgc ccctcgacca ccaccaacag cggcctcatg     1500

gcccccgatt tgtacgtgta cgtggatccc gcgttcacgg ccaacacccg agcctccggg     1560

accggcgtcg ctgtcgtcgg gcggtaccgc gacgattata tcatcttcgc cctggagcac     1620

ttttttctcc gcgcgctcac gggctcggcc cccgccgaca tcgcccgctg cgtcgtccac     1680

agtctgacgc aggtcctggc cctgcatccc ggggcgtttc gcggcgtccg ggtggcggtc     1740

gagggaaata gcagccagga ctcggccgtc gccatcgcca cgcacgtgca cacagagatg     1800

caccgcctac tggcctcgga gggggccgac gcgggctcgg gccccgagct tctcttctac     1860

cactgcgagc ctcccgggag cgcggtgctg tacccctttt tcctgctcaa caaacagaag     1920

acgcccgcct ttgaacactt tattaaaaag tttaactccg ggggcgtcat ggcctcccag     1980

gagatcgttt ccgcgacggt gcgcctgcag accgacccgg tcgagtatct gctcgagcag     2040

ctgaataacc tcaccgaaac cgtctccccc aacacggacg tccgtacgta ttccggaaaa     2100

cggaacggcg cctcggatga ccttatggtc gccgtcatta tggccatcta ccttgcggcc     2160

caggccggac ctccgcacac attcgctccc atcacacgcg tttcgtga                  2208


<210>  40
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  40

Met Phe Gly Gln Gln Leu Ala Ser Asp Val Gln Gln Tyr Leu Glu Arg 
1               5                   10                  15      


Leu Glu Lys Gln Arg Gln Leu Lys Val Gly Ala Asp Glu Ala Ser Ala 
            20                  25                  30          


Gly Leu Thr Met Gly Gly Asp Ala Leu Arg Val Pro Phe Leu Asp Phe 
        35                  40                  45              


Ala Thr Ala Thr Pro Lys Arg His Gln Thr Val Val Pro Gly Val Gly 
    50                  55                  60                  


Thr Leu His Asp Cys Cys Glu His Ser Pro Leu Phe Ser Ala Val Ala 
65                  70                  75                  80  


Arg Arg Leu Leu Phe Asn Ser Leu Val Pro Ala Gln Leu Lys Gly Arg 
                85                  90                  95      


Asp Phe Gly Gly Asp His Thr Ala Lys Leu Glu Phe Leu Ala Pro Glu 
            100                 105                 110         


Leu Val Arg Ala Val Ala Arg Leu Arg Phe Lys Glu Cys Ala Pro Ala 
        115                 120                 125             


Asp Val Val Pro Gln Arg Asn Ala Tyr Tyr Ser Val Leu Asn Thr Phe 
    130                 135                 140                 


Gln Ala Leu His Arg Ser Glu Ala Phe Arg Gln Leu Val His Phe Val 
145                 150                 155                 160 


Arg Asp Phe Ala Gln Leu Leu Lys Thr Ser Phe Arg Ala Ser Ser Leu 
                165                 170                 175     


Thr Glu Thr Thr Gly Pro Pro Lys Lys Arg Ala Lys Val Asp Val Ala 
            180                 185                 190         


Thr His Gly Arg Thr Tyr Gly Thr Leu Glu Leu Phe Gln Lys Met Ile 
        195                 200                 205             


Leu Met His Ala Thr Tyr Phe Leu Ala Ala Val Leu Leu Gly Asp His 
    210                 215                 220                 


Ala Glu Gln Val Asn Thr Phe Leu Arg Leu Val Phe Glu Ile Pro Leu 
225                 230                 235                 240 


Phe Ser Asp Ala Ala Val Arg His Phe Arg Gln Arg Ala Thr Val Phe 
                245                 250                 255     


Leu Val Pro Arg Arg His Gly Lys Thr Trp Phe Leu Val Pro Leu Ile 
            260                 265                 270         


Ala Leu Ser Leu Ala Ser Phe Arg Gly Ile Lys Ile Gly Tyr Thr Ala 
        275                 280                 285             


His Ile Arg Lys Ala Thr Glu Pro Val Phe Glu Glu Ile Asp Ala Cys 
    290                 295                 300                 


Leu Arg Gly Trp Phe Gly Ser Ala Arg Val Asp His Val Lys Gly Glu 
305                 310                 315                 320 


Thr Ile Ser Phe Ser Phe Pro Asp Gly Ser Arg Ser Thr Ile Val Phe 
                325                 330                 335     


Ala Ser Ser His Asn Thr Asn Gly Ile Arg Gly Gln Asp Phe Asn Leu 
            340                 345                 350         


Leu Phe Val Asp Glu Ala Asn Phe Ile Arg Pro Asp Ala Val Gln Thr 
        355                 360                 365             


Ile Met Gly Phe Leu Asn Gln Ala Asn Cys Lys Ile Ile Phe Val Ser 
    370                 375                 380                 


Ser Thr Asn Thr Gly Lys Ala Ser Thr Ser Phe Leu Tyr Asn Leu Arg 
385                 390                 395                 400 


Gly Ala Ala Asp Glu Leu Leu Asn Val Val Thr Tyr Ile Cys Asp Asp 
                405                 410                 415     


His Met Pro Arg Val Val Thr His Thr Asn Ala Thr Ala Cys Ser Cys 
            420                 425                 430         


Tyr Ile Leu Asn Lys Pro Val Phe Ile Thr Met Asp Gly Ala Val Arg 
        435                 440                 445             


Arg Thr Ala Asp Leu Phe Leu Ala Asp Ser Phe Met Gln Glu Ile Ile 
    450                 455                 460                 


Gly Gly Gln Ala Arg Glu Thr Gly Asp Asp Arg Pro Val Leu Thr Lys 
465                 470                 475                 480 


Ser Ala Gly Glu Arg Phe Leu Leu Tyr Arg Pro Ser Thr Thr Thr Asn 
                485                 490                 495     


Ser Gly Leu Met Ala Pro Asp Leu Tyr Val Tyr Val Asp Pro Ala Phe 
            500                 505                 510         


Thr Ala Asn Thr Arg Ala Ser Gly Thr Gly Val Ala Val Val Gly Arg 
        515                 520                 525             


Tyr Arg Asp Asp Tyr Ile Ile Phe Ala Leu Glu His Phe Phe Leu Arg 
    530                 535                 540                 


Ala Leu Thr Gly Ser Ala Pro Ala Asp Ile Ala Arg Cys Val Val His 
545                 550                 555                 560 


Ser Leu Thr Gln Val Leu Ala Leu His Pro Gly Ala Phe Arg Gly Val 
                565                 570                 575     


Arg Val Ala Val Glu Gly Asn Ser Ser Gln Asp Ser Ala Val Ala Ile 
            580                 585                 590         


Ala Thr His Val His Thr Glu Met His Arg Leu Leu Ala Ser Glu Gly 
        595                 600                 605             


Ala Asp Ala Gly Ser Gly Pro Glu Leu Leu Phe Tyr His Cys Glu Pro 
    610                 615                 620                 


Pro Gly Ser Ala Val Leu Tyr Pro Phe Phe Leu Leu Asn Lys Gln Lys 
625                 630                 635                 640 


Thr Pro Ala Phe Glu His Phe Ile Lys Lys Phe Asn Ser Gly Gly Val 
                645                 650                 655     


Met Ala Ser Gln Glu Ile Val Ser Ala Thr Val Arg Leu Gln Thr Asp 
            660                 665                 670         


Pro Val Glu Tyr Leu Leu Glu Gln Leu Asn Asn Leu Thr Glu Thr Val 
        675                 680                 685             


Ser Pro Asn Thr Asp Val Arg Thr Tyr Ser Gly Lys Arg Asn Gly Ala 
    690                 695                 700                 


Ser Asp Asp Leu Met Val Ala Val Ile Met Ala Ile Tyr Leu Ala Ala 
705                 710                 715                 720 


Gln Ala Gly Pro Pro His Thr Phe Ala Pro Ile Thr Arg Val Ser 
                725                 730                 735 


<210>  41
<211>  2208
<212>  DNA
<213>  Herpes simplex virus type 1

<400>  41
atgtttggtc agcagctggc gtccgacgtc cagcagtacc tggagcgcct cgagaaacag       60

aggcaactta aggtgggcgc ggacgaggcg tcggcgggcc tcaccatggg cggcgatgcc      120

ctacgagtgc cctttttaga tttcgcgacc gcgaccccca agcgccacca gaccgtggtc      180

cctggcgtcg ggacgctcca cgactgctgc gagcactcgc cgctcttctc ggccgtggcg      240

cggcggctgc tgtttaatag cctggtgccg gcgcaactaa aggggcgtga tttcgggggc      300

gaccacacgg ccaagctgga attcctggcc cccgagttgg tacgggcggt ggcgcgactg      360

cggtttaagg agtgcgcgcc ggcggacgtg gtgcctcagc gtaacgccta ctatagcgtt      420

ctgaatacgt ttcaggccct ccaccgctcc gaagcctttc gccagctggt gcactttgtg      480

cgggactttg cccagctgct caaaacctcc ttccgggcct ccagcctcac ggagaccacg      540

ggccccccca aaaaacgggc caaggtggac gtggccaccc acggccggac gtacggcacg      600

ctggagctgt tccaaaaaat gatccttatg cacgccacct actttctggc cgccgtgctc      660

ctcggggacc acgcggagca ggtcaacacg ttcctgcgtc tcgtgtttga gatccccctg      720

tttagcgacg cggccgtgcg ccacttccgc cagcgcgcca ccgtgtttct cgtcccccgg      780

cgccacggca agacctggtt tctggtgccc ctcatcgcgc tgtcgctggc ctcctttcgg      840

gggatcaaga tcggctacac ggcgcacatc cgcaaggcga ccgagccggt gtttgaggag      900

atcgacgcct gcctgcgggg ctggttcggt tcggcccgag tggaccacgt taaaggggaa      960

accatctcct tctcgtttcc ggacgggtcg cgcagtacca tcgtgtttgc ctccagccac     1020

aacacaaacg gaatccgagg ccaggacttt aacctgctct ttgtcgacga ggccaacttt     1080

attcgcccgg atgcggtcca gacgattatg ggctttctca accaggccaa ctgcaagatt     1140

atcttcgtgt cgtccaccaa caccgggaag gccagtacga gctttttgta caacctccgc     1200

ggggccgcag acgagcttct caacgtggtg acctatatat gcgatgatca catgccgagg     1260

gtggtgacgc acacaaacgc cacggcctgt tcttgttata tcctcaacaa gcccgttttc     1320

atcacgatgg acggggcggt tcgccggacc gccgatttgt ttctggccga ttccttcatg     1380

caggagatca tcgggggcca ggccagggag accggcgacg accggcccgt tctgaccaag     1440

tctgcggggg agcggtttct gttgtaccgc ccctcgacca ccaccaacag cggcctcatg     1500

gcccccgatt tgtacgtgta cgtggatccc gcgttcacgg ccaacacccg agcctccggg     1560

accggcgtcg ctgtcgtcgg gcggtaccgc gacgattata tcatcttcgc cctggagcac     1620

ttttttctcc gcgcgctcac gggctcggcc cccgccgaca tcgcccgctg cgtcgtccac     1680

agtctgacgc aggtcctggc cctgcatccc ggggcgtttc gcggcgtccg ggtggcggtc     1740

gagggaaata gcagccagga ctcggccgtc gccatcgcca cgcacgtgca cacagagatg     1800

caccgcctac tggcctcgga gggggccgac gcgggctcgg gccccgagct tctcttctac     1860

cactgcgagc ctcccgggag cgcggtgctg tacccctttt tcctgctcaa caaacagaag     1920

acgcccgcct ttgaacactt tattaaaaag tttaactccg ggggcgtcat ggcctcccag     1980

gagatcgttt ccgcgacggt gcgcctgcag accgacccgg tcgagtatct gctcgagcag     2040

ctaaataacc tcaccgaaac cgtctccccc aacactgacg tccgtacgta ttccggaaaa     2100

cggaacggcg cctcggatga ccttatggtc gccgtcatta tggccatcta cctcgcggcc     2160

caggccggac ctccgcacac attcgctcct atcatacgcg tctcgtga                  2208


<210>  42
<211>  735
<212>  PRT
<213>  Herpes simplex virus type 1

<400>  42

Met Phe Gly Gln Gln Leu Ala Ser Asp Val Gln Gln Tyr Leu Glu Arg 
1               5                   10                  15      


Leu Glu Lys Gln Arg Gln Leu Lys Val Gly Ala Asp Glu Ala Ser Ala 
            20                  25                  30          


Gly Leu Thr Met Gly Gly Asp Ala Leu Arg Val Pro Phe Leu Asp Phe 
        35                  40                  45              


Ala Thr Ala Thr Pro Lys Arg His Gln Thr Val Val Pro Gly Val Gly 
    50                  55                  60                  


Thr Leu His Asp Cys Cys Glu His Ser Pro Leu Phe Ser Ala Val Ala 
65                  70                  75                  80  


Arg Arg Leu Leu Phe Asn Ser Leu Val Pro Ala Gln Leu Lys Gly Arg 
                85                  90                  95      


Asp Phe Gly Gly Asp His Thr Ala Lys Leu Glu Phe Leu Ala Pro Glu 
            100                 105                 110         


Leu Val Arg Ala Val Ala Arg Leu Arg Phe Lys Glu Cys Ala Pro Ala 
        115                 120                 125             


Asp Val Val Pro Gln Arg Asn Ala Tyr Tyr Ser Val Leu Asn Thr Phe 
    130                 135                 140                 


Gln Ala Leu His Arg Ser Glu Ala Phe Arg Gln Leu Val His Phe Val 
145                 150                 155                 160 


Arg Asp Phe Ala Gln Leu Leu Lys Thr Ser Phe Arg Ala Ser Ser Leu 
                165                 170                 175     


Thr Glu Thr Thr Gly Pro Pro Lys Lys Arg Ala Lys Val Asp Val Ala 
            180                 185                 190         


Thr His Gly Arg Thr Tyr Gly Thr Leu Glu Leu Phe Gln Lys Met Ile 
        195                 200                 205             


Leu Met His Ala Thr Tyr Phe Leu Ala Ala Val Leu Leu Gly Asp His 
    210                 215                 220                 


Ala Glu Gln Val Asn Thr Phe Leu Arg Leu Val Phe Glu Ile Pro Leu 
225                 230                 235                 240 


Phe Ser Asp Ala Ala Val Arg His Phe Arg Gln Arg Ala Thr Val Phe 
                245                 250                 255     


Leu Val Pro Arg Arg His Gly Lys Thr Trp Phe Leu Val Pro Leu Ile 
            260                 265                 270         


Ala Leu Ser Leu Ala Ser Phe Arg Gly Ile Lys Ile Gly Tyr Thr Ala 
        275                 280                 285             


His Ile Arg Lys Ala Thr Glu Pro Val Phe Glu Glu Ile Asp Ala Cys 
    290                 295                 300                 


Leu Arg Gly Trp Phe Gly Ser Ala Arg Val Asp His Val Lys Gly Glu 
305                 310                 315                 320 


Thr Ile Ser Phe Ser Phe Pro Asp Gly Ser Arg Ser Thr Ile Val Phe 
                325                 330                 335     


Ala Ser Ser His Asn Thr Asn Gly Ile Arg Gly Gln Asp Phe Asn Leu 
            340                 345                 350         


Leu Phe Val Asp Glu Ala Asn Phe Ile Arg Pro Asp Ala Val Gln Thr 
        355                 360                 365             


Ile Met Gly Phe Leu Asn Gln Ala Asn Cys Lys Ile Ile Phe Val Ser 
    370                 375                 380                 


Ser Thr Asn Thr Gly Lys Ala Ser Thr Ser Phe Leu Tyr Asn Leu Arg 
385                 390                 395                 400 


Gly Ala Ala Asp Glu Leu Leu Asn Val Val Thr Tyr Ile Cys Asp Asp 
                405                 410                 415     


His Met Pro Arg Val Val Thr His Thr Asn Ala Thr Ala Cys Ser Cys 
            420                 425                 430         


Tyr Ile Leu Asn Lys Pro Val Phe Ile Thr Met Asp Gly Ala Val Arg 
        435                 440                 445             


Arg Thr Ala Asp Leu Phe Leu Ala Asp Ser Phe Met Gln Glu Ile Ile 
    450                 455                 460                 


Gly Gly Gln Ala Arg Glu Thr Gly Asp Asp Arg Pro Val Leu Thr Lys 
465                 470                 475                 480 


Ser Ala Gly Glu Arg Phe Leu Leu Tyr Arg Pro Ser Thr Thr Thr Asn 
                485                 490                 495     


Ser Gly Leu Met Ala Pro Asp Leu Tyr Val Tyr Val Asp Pro Ala Phe 
            500                 505                 510         


Thr Ala Asn Thr Arg Ala Ser Gly Thr Gly Val Ala Val Val Gly Arg 
        515                 520                 525             


Tyr Arg Asp Asp Tyr Ile Ile Phe Ala Leu Glu His Phe Phe Leu Arg 
    530                 535                 540                 


Ala Leu Thr Gly Ser Ala Pro Ala Asp Ile Ala Arg Cys Val Val His 
545                 550                 555                 560 


Ser Leu Thr Gln Val Leu Ala Leu His Pro Gly Ala Phe Arg Gly Val 
                565                 570                 575     


Arg Val Ala Val Glu Gly Asn Ser Ser Gln Asp Ser Ala Val Ala Ile 
            580                 585                 590         


Ala Thr His Val His Thr Glu Met His Arg Leu Leu Ala Ser Glu Gly 
        595                 600                 605             


Ala Asp Ala Gly Ser Gly Pro Glu Leu Leu Phe Tyr His Cys Glu Pro 
    610                 615                 620                 


Pro Gly Ser Ala Val Leu Tyr Pro Phe Phe Leu Leu Asn Lys Gln Lys 
625                 630                 635                 640 


Thr Pro Ala Phe Glu His Phe Ile Lys Lys Phe Asn Ser Gly Gly Val 
                645                 650                 655     


Met Ala Ser Gln Glu Ile Val Ser Ala Thr Val Arg Leu Gln Thr Asp 
            660                 665                 670         


Pro Val Glu Tyr Leu Leu Glu Gln Leu Asn Asn Leu Thr Glu Thr Val 
        675                 680                 685             


Ser Pro Asn Thr Asp Val Arg Thr Tyr Ser Gly Lys Arg Asn Gly Ala 
    690                 695                 700                 


Ser Asp Asp Leu Met Val Ala Val Ile Met Ala Ile Tyr Leu Ala Ala 
705                 710                 715                 720 


Gln Ala Gly Pro Pro His Thr Phe Ala Pro Ile Ile Arg Val Ser 
                725                 730                 735 


<210>  43
<211>  3414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  43
atggccagcc gcccagccgc atcctctccc gtcgaagcgc gggccccggt tgggggacag       60

gaggccggcg gccccagcgc agccacccag ggggaggccg ccggggcccc tctcgcccac      120

ggccaccacg tgtactgcca gcgagtcaat ggcgtgatgg tgctttccga caagacgccc      180

gggtccgcgt cctaccgcat cagcgatagc aactttgtcc aatgtggttc caactgcacc      240

atgatcatcg acggagacgt ggtgcgcggg cgcccccagg acccgggggc cgcggcatcc      300

cccgctccct tcgttgcggt gacaaacatc ggagccggca gcgacggcgg gaccgccgtc      360

gtggcattcg ggggaacccc acgtcgctcg gcggggacgt ctaccggtac ccagacggcc      420

gacgtcccca ccgaggccct tgggggcccc cctcctcctc cccgcttcac cctgggtggc      480

ggctgttgtt cctgtcgcga cacacggcgc cgctctgcgg tattcggggg ggagggggat      540

ccagtcggcc ccgcggagtt cgtctcggac gaccggtcgt ccgattccga ctcggatgac      600

tcggaggaca cggactcgga gacgctgtca cacgcctcct cggacgtgtc cggcggggcc      660

acgtacgacg acgcccttga ctccgattcg tcatcggatg actccctgca gatagatggc      720

cccgtgtgtc gcccgtggag caatgacacc gcgcccctgg atgtttgccc cgggaccccc      780

ggcccgggcg ccgacgccgg tggtccctca gcggtagacc cacacgcgcc gacgccagag      840

gccggcgctg gtcttgcggc cgatcccgcc gtggcccggg acgacgcgga ggggctttcg      900

gacccccggc cacgtctggg aacgggcacg gcctaccccg tccccctgga actcacgccc      960

gagaacgcgg aggccgtggc gcgctttctg ggagatgccg tgaaccgcga acccgcgctc     1020

atgctggagt acttttgccg gtgcgcccgc gaggaaacca agcgtgtccc ccccaggaca     1080

ttcggcagcc cccctcgcct cacggaggac gactttgggc ttctcaacta cgcgctcgtg     1140

gagatgcagc gcctgtgtct ggacgttcct ccggtcccgc cgaacgcata catgccctat     1200

tatctcaggg agtatgtgac gcggctggtc aacgggttca agccgctggt gagccggtcc     1260

gctcgccttt accgcatcct gggggttctg gtgcacctgc ggatccggac ccgggaggcc     1320

tcctttgagg agtggctgcg atccaaggaa gtggccctgg attttggcct gacggaaagg     1380

cttcgcgagc acgaagccca gctggtgatc ctggcccagg ctctggacca ttacgactgt     1440

ctgatccaca gcacaccgca cacgctggtc gagcgggggc tgcaatcggc cctgaagtat     1500

gaggagtttt acctaaagcg ttttggcggg cactacatgg agtccgtctt ccagatgtac     1560

acccgcatcg ccggcttttt ggcctgccgg gccacgcgcg gcatgcgcca catcgccctg     1620

gggcgagagg ggtcgtggtg ggaaatgttc aagttctttt tccaccgcct ctacgaccac     1680

cagatcgtac cgtcgacccc cgccatgctg aacctgggga cccgcaacta ctacacctcc     1740

agctgctacc tggtaaaccc ccaggccacc acaaacaagg cgaccctgcg ggccatcacc     1800

agcaacgtca gtgccatcct cgcccgcaac gggggcatcg ggctatgcgt gcaggcgttt     1860

aacgactccg gccccgggac cgccagcgtc atgcccgccc tcaaggtcct tgactcgctg     1920

gtggcggcgc acaacaaaga gagcgcgcgt ccgaccggcg cgtgcgtgta cctggagccg     1980

tggcacaccg acgtgcgggc cgtgctccgg atgaaggggg tcctcgccgg cgaagaggcc     2040

cagcgctgcg acaatatctt cagcgccctc tggatgccag acctgttttt caagcgcctg     2100

attcgccacc tggacggcga gaagaacgtc acatggaccc tgttcgaccg ggacaccagc     2160

atgtcgctcg ccgactttca cggggaggag ttcgagaagc tctaccagca cctcgaggtc     2220

atggggttcg gcgagcagat acccatccag gagctggcct atggcattgt gcgcagtgcg     2280

gccacgaccg ggagcccctt cgtcatgttc aaagacgcgg tgaaccgcca ctacatctac     2340

gacacccagg gggcggccat cgccggctcc aacctctgca ccgagatcgt ccatccggcc     2400

tccaagcgat ccagtggggt ctgcaacctg ggaagcgtga atctggcccg atgcgtctcc     2460

aggcagacgt ttgactttgg gcggctccgc gacgccgtgc aggcgtgcgt gctgatggtg     2520

aacatcatga tcgacagcac gctacaaccc acgccccagt gcacccgcgg caacgacaac     2580

ctgcggtcca tgggaatcgg catgcagggc ctgcacacgg cctgcctgaa gctggggctg     2640

gatctggagt ctgtcgaatt tcaggacctg aacaaacaca tcgccgaggt gatgctgctg     2700

tcggcgatga agaccagcaa cgcgctgtgc gttcgcgggg cccgtccctt caaccacttt     2760

aagcgcagca tgtatcgcgc cggccgcttt cactgggagc gctttccgga cgcccggccg     2820

cggtacgagg gcgagtggga gatgctacgc cagagcatga tgaaacacgg cctgcgcaac     2880

agccagtttg tcgcgctgat gcccaccgcc gcctcggcgc agatctcgga cgtcagcgag     2940

ggctttgccc ccctgttcac caacctgttc agcaaggtga cccgggacgg cgagacgctg     3000

cgccccaaca cgctcctgct aaaggaactg gaacgcacgt ttagcgggaa gcgcctcctg     3060

gaggtgatgg acagtctcga cgccaagcag tggtccgtgg cgcaggcgct cccgtgcctg     3120

gagcccaccc accccctccg gcgattcaag accgcgtttg actacgacca gaagttgctg     3180

atcgacctgt gtgcggaccg cgccccctac gtcgaccata gccaatccat gaccctgtat     3240

gtcacggaga aggcggacgg gaccctccca gcctccaccc tggtccgcct tctggtccac     3300

gcatataagc gcggactaaa aacagggatg tactactgca aggttcgcaa ggcgaccaac     3360

agcggggtct ttggcggcga cgacaacatt gtctgcacga gctgcgcgct gtga           3414


<210>  44
<211>  1137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  44

Met Ala Ser Arg Pro Ala Ala Ser Ser Pro Val Glu Ala Arg Ala Pro 
1               5                   10                  15      


Val Gly Gly Gln Glu Ala Gly Gly Pro Ser Ala Ala Thr Gln Gly Glu 
            20                  25                  30          


Ala Ala Gly Ala Pro Leu Ala His Gly His His Val Tyr Cys Gln Arg 
        35                  40                  45              


Val Asn Gly Val Met Val Leu Ser Asp Lys Thr Pro Gly Ser Ala Ser 
    50                  55                  60                  


Tyr Arg Ile Ser Asp Ser Asn Phe Val Gln Cys Gly Ser Asn Cys Thr 
65                  70                  75                  80  


Met Ile Ile Asp Gly Asp Val Val Arg Gly Arg Pro Gln Asp Pro Gly 
                85                  90                  95      


Ala Ala Ala Ser Pro Ala Pro Phe Val Ala Val Thr Asn Ile Gly Ala 
            100                 105                 110         


Gly Ser Asp Gly Gly Thr Ala Val Val Ala Phe Gly Gly Thr Pro Arg 
        115                 120                 125             


Arg Ser Ala Gly Thr Ser Thr Gly Thr Gln Thr Ala Asp Val Pro Thr 
    130                 135                 140                 


Glu Ala Leu Gly Gly Pro Pro Pro Pro Pro Arg Phe Thr Leu Gly Gly 
145                 150                 155                 160 


Gly Cys Cys Ser Cys Arg Asp Thr Arg Arg Arg Ser Ala Val Phe Gly 
                165                 170                 175     


Gly Glu Gly Asp Pro Val Gly Pro Ala Glu Phe Val Ser Asp Asp Arg 
            180                 185                 190         


Ser Ser Asp Ser Asp Ser Asp Asp Ser Glu Asp Thr Asp Ser Glu Thr 
        195                 200                 205             


Leu Ser His Ala Ser Ser Asp Val Ser Gly Gly Ala Thr Tyr Asp Asp 
    210                 215                 220                 


Ala Leu Asp Ser Asp Ser Ser Ser Asp Asp Ser Leu Gln Ile Asp Gly 
225                 230                 235                 240 


Pro Val Cys Arg Pro Trp Ser Asn Asp Thr Ala Pro Leu Asp Val Cys 
                245                 250                 255     


Pro Gly Thr Pro Gly Pro Gly Ala Asp Ala Gly Gly Pro Ser Ala Val 
            260                 265                 270         


Asp Pro His Ala Pro Thr Pro Glu Ala Gly Ala Gly Leu Ala Ala Asp 
        275                 280                 285             


Pro Ala Val Ala Arg Asp Asp Ala Glu Gly Leu Ser Asp Pro Arg Pro 
    290                 295                 300                 


Arg Leu Gly Thr Gly Thr Ala Tyr Pro Val Pro Leu Glu Leu Thr Pro 
305                 310                 315                 320 


Glu Asn Ala Glu Ala Val Ala Arg Phe Leu Gly Asp Ala Val Asn Arg 
                325                 330                 335     


Glu Pro Ala Leu Met Leu Glu Tyr Phe Cys Arg Cys Ala Arg Glu Glu 
            340                 345                 350         


Thr Lys Arg Val Pro Pro Arg Thr Phe Gly Ser Pro Pro Arg Leu Thr 
        355                 360                 365             


Glu Asp Asp Phe Gly Leu Leu Asn Tyr Ala Leu Val Glu Met Gln Arg 
    370                 375                 380                 


Leu Cys Leu Asp Val Pro Pro Val Pro Pro Asn Ala Tyr Met Pro Tyr 
385                 390                 395                 400 


Tyr Leu Arg Glu Tyr Val Thr Arg Leu Val Asn Gly Phe Lys Pro Leu 
                405                 410                 415     


Val Ser Arg Ser Ala Arg Leu Tyr Arg Ile Leu Gly Val Leu Val His 
            420                 425                 430         


Leu Arg Ile Arg Thr Arg Glu Ala Ser Phe Glu Glu Trp Leu Arg Ser 
        435                 440                 445             


Lys Glu Val Ala Leu Asp Phe Gly Leu Thr Glu Arg Leu Arg Glu His 
    450                 455                 460                 


Glu Ala Gln Leu Val Ile Leu Ala Gln Ala Leu Asp His Tyr Asp Cys 
465                 470                 475                 480 


Leu Ile His Ser Thr Pro His Thr Leu Val Glu Arg Gly Leu Gln Ser 
                485                 490                 495     


Ala Leu Lys Tyr Glu Glu Phe Tyr Leu Lys Arg Phe Gly Gly His Tyr 
            500                 505                 510         


Met Glu Ser Val Phe Gln Met Tyr Thr Arg Ile Ala Gly Phe Leu Ala 
        515                 520                 525             


Cys Arg Ala Thr Arg Gly Met Arg His Ile Ala Leu Gly Arg Glu Gly 
    530                 535                 540                 


Ser Trp Trp Glu Met Phe Lys Phe Phe Phe His Arg Leu Tyr Asp His 
545                 550                 555                 560 


Gln Ile Val Pro Ser Thr Pro Ala Met Leu Asn Leu Gly Thr Arg Asn 
                565                 570                 575     


Tyr Tyr Thr Ser Ser Cys Tyr Leu Val Asn Pro Gln Ala Thr Thr Asn 
            580                 585                 590         


Lys Ala Thr Leu Arg Ala Ile Thr Ser Asn Val Ser Ala Ile Leu Ala 
        595                 600                 605             


Arg Asn Gly Gly Ile Gly Leu Cys Val Gln Ala Phe Asn Asp Ser Gly 
    610                 615                 620                 


Pro Gly Thr Ala Ser Val Met Pro Ala Leu Lys Val Leu Asp Ser Leu 
625                 630                 635                 640 


Val Ala Ala His Asn Lys Glu Ser Ala Arg Pro Thr Gly Ala Cys Val 
                645                 650                 655     


Tyr Leu Glu Pro Trp His Thr Asp Val Arg Ala Val Leu Arg Met Lys 
            660                 665                 670         


Gly Val Leu Ala Gly Glu Glu Ala Gln Arg Cys Asp Asn Ile Phe Ser 
        675                 680                 685             


Ala Leu Trp Met Pro Asp Leu Phe Phe Lys Arg Leu Ile Arg His Leu 
    690                 695                 700                 


Asp Gly Glu Lys Asn Val Thr Trp Thr Leu Phe Asp Arg Asp Thr Ser 
705                 710                 715                 720 


Met Ser Leu Ala Asp Phe His Gly Glu Glu Phe Glu Lys Leu Tyr Gln 
                725                 730                 735     


His Leu Glu Val Met Gly Phe Gly Glu Gln Ile Pro Ile Gln Glu Leu 
            740                 745                 750         


Ala Tyr Gly Ile Val Arg Ser Ala Ala Thr Thr Gly Ser Pro Phe Val 
        755                 760                 765             


Met Phe Lys Asp Ala Val Asn Arg His Tyr Ile Tyr Asp Thr Gln Gly 
    770                 775                 780                 


Ala Ala Ile Ala Gly Ser Asn Leu Cys Thr Glu Ile Val His Pro Ala 
785                 790                 795                 800 


Ser Lys Arg Ser Ser Gly Val Cys Asn Leu Gly Ser Val Asn Leu Ala 
                805                 810                 815     


Arg Cys Val Ser Arg Gln Thr Phe Asp Phe Gly Arg Leu Arg Asp Ala 
            820                 825                 830         


Val Gln Ala Cys Val Leu Met Val Asn Ile Met Ile Asp Ser Thr Leu 
        835                 840                 845             


Gln Pro Thr Pro Gln Cys Thr Arg Gly Asn Asp Asn Leu Arg Ser Met 
    850                 855                 860                 


Gly Ile Gly Met Gln Gly Leu His Thr Ala Cys Leu Lys Leu Gly Leu 
865                 870                 875                 880 


Asp Leu Glu Ser Val Glu Phe Gln Asp Leu Asn Lys His Ile Ala Glu 
                885                 890                 895     


Val Met Leu Leu Ser Ala Met Lys Thr Ser Asn Ala Leu Cys Val Arg 
            900                 905                 910         


Gly Ala Arg Pro Phe Asn His Phe Lys Arg Ser Met Tyr Arg Ala Gly 
        915                 920                 925             


Arg Phe His Trp Glu Arg Phe Pro Asp Ala Arg Pro Arg Tyr Glu Gly 
    930                 935                 940                 


Glu Trp Glu Met Leu Arg Gln Ser Met Met Lys His Gly Leu Arg Asn 
945                 950                 955                 960 


Ser Gln Phe Val Ala Leu Met Pro Thr Ala Ala Ser Ala Gln Ile Ser 
                965                 970                 975     


Asp Val Ser Glu Gly Phe Ala Pro Leu Phe Thr Asn Leu Phe Ser Lys 
            980                 985                 990         


Val Thr Arg Asp Gly Glu Thr Leu  Arg Pro Asn Thr Leu  Leu Leu Lys 
        995                 1000                 1005             


Glu Leu  Glu Arg Thr Phe Ser  Gly Lys Arg Leu Leu  Glu Val Met 
    1010                 1015                 1020             


Asp Ser  Leu Asp Ala Lys Gln  Trp Ser Val Ala Gln  Ala Leu Pro 
    1025                 1030                 1035             


Cys Leu  Glu Pro Thr His Pro  Leu Arg Arg Phe Lys  Thr Ala Phe 
    1040                 1045                 1050             


Asp Tyr  Asp Gln Lys Leu Leu  Ile Asp Leu Cys Ala  Asp Arg Ala 
    1055                 1060                 1065             


Pro Tyr  Val Asp His Ser Gln  Ser Met Thr Leu Tyr  Val Thr Glu 
    1070                 1075                 1080             


Lys Ala  Asp Gly Thr Leu Pro  Ala Ser Thr Leu Val  Arg Leu Leu 
    1085                 1090                 1095             


Val His  Ala Tyr Lys Arg Gly  Leu Lys Thr Gly Met  Tyr Tyr Cys 
    1100                 1105                 1110             


Lys Val  Arg Lys Ala Thr Asn  Ser Gly Val Phe Gly  Gly Asp Asp 
    1115                 1120                 1125             


Asn Ile  Val Cys Thr Ser Cys  Ala Leu 
    1130                 1135         


<210>  45
<211>  3414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  45
atggccagcc gcccagccgc atcctctccc gtcgaagcgc gggccccggt tgggggacag       60

gaggccggcg gccccagcgc agccacccag ggggaggccg ccggggcccc tctcgcccac      120

ggccaccacg tgtactgcca gcgagtcaat ggcgtgatgg tgctttccga caagacgccc      180

gggtccgcgt cctaccgcat cagcgatagc aactttgtcc aatgtggttc caactgcacc      240

atgatcatcg acggagacgt ggtgcgcggg cgcccccagg acccgggggc cgcggcatcc      300

cccgctccct tcgttgcggt gacaaacatc ggagccggca gcgacggcgg gaccgccgtc      360

gtggcattcg ggggaacccc acgtcgctcg gcggggacgt ctaccggtac ccagacggcc      420

gacgtcccca ccgaggccct tgggggcccc cctcctcctc cccgcttcac cctgggtggc      480

ggctgttgtt cctgtcgcga cacacggcgc cgctctgcgg tattcggggg ggagggggat      540

ccagtcggcc ccgcggagtt cgtctcggac gaccggtcgt ccgattccga ctcggatgac      600

tcggaggaca cggactcgga gacgctgtca cacgcctcct cggacgtgtc cggcggggcc      660

acgtacgacg acgcccttga ctccgattcg tcatcggatg actccctgca gatagatggc      720

cccgtgtgtc gcccgtggag caatgacacc gcgcccctgg atgtttgccc cgggaccccc      780

ggcccgggcg ccgacgccgg tggtccctca gcggtagacc cacacgcgcc gacgccagag      840

gccggcgctg gtcttgcggc cgatcccgcc gtggcccggg acgacgcgga ggggctttcg      900

gacccccggc cacgtctggg aacgggcacg gcctaccccg tccccctgga actcacgccc      960

gagaacgcgg aggccgtggc gcgctttctg ggagatgccg tgaaccgcga acccgcgctc     1020

atgctggagt acttttgccg gtgcgcccgc gaggaaacca agcgtgtccc ccccaggaca     1080

ttcggcagcc cccctcgcct cacggaggac gactttgggc ttctcaacta cgcgctcgtg     1140

gagatgcagc gcctgtgtct ggacgttcct ccggtcccgc cgaacgcata catgccctat     1200

tatctcaggg agtatgtgac gcggctggtc aacgggttca agccgctggt gagccggtcc     1260

gctcgccttt accgcatcct gggggttctg gtgcacctgc ggatccggac ccgggaggcc     1320

tcctttgagg agtggctgcg atccaaggaa gtggccctgg attttggcct gacggaaagg     1380

cttcgcgagc acgaagccca gctggtgatc ctggcccagg ctctggacca ttacgactgt     1440

ctgatccaca gcacaccgca cacgctggtc gagcgggggc tgcaatcggc cctgaagtat     1500

gaggagtttt acctaaagcg ttttggcggg cactacatgg agtccgtctt ccagatgtac     1560

acccgcatcg ccggcttttt ggcctgccgg gccacgcgcg gcatgcgcca catcgccctg     1620

gggcgagagg ggtcgtggtg ggaaatgttc aagttctttt tccaccgcct ctacgaccac     1680

cagatcgtac cgtcgacccc cgccatgctg aacctgggga cccgcaacta ctacacctcc     1740

agctgctacc tggtaaaccc ccaggccacc acaaacaagg cgaccctgcg ggccatcacc     1800

agcaacgtca gtgccatcct cgcccgcaac gggggcatcg ggctatgcgt gcaggcgttt     1860

aacgactccg gccccgggac cgccagcgtc atgcccgccc tcaaggtcct tgactcgctg     1920

gtggcggcgc acaacaaaga gagcgcgcgt ccgaccggcg cgtgcgtgta cctggagccg     1980

tggcacaccg acgtgcgggc cgtgctccgg atgaaggggg tcctcgccgg cgaagaggcc     2040

cagcgctgcg acaatatctt cagcgccctc tggatgccag acctgttttt caagcgcctg     2100

attcgccacc tggacggcga gaagaacgtc acatggaccc tgttcgaccg ggacaccagc     2160

atgtcgctcg ccgactttca cggggaggag ttcgagaagc tctaccagca cctcgaggtc     2220

atggggttcg gcgagcagat acccatccag gagctggcct atggcattgt gcgcagtgcg     2280

gccacgaccg ggagcccctt cgtcatgttc aaagacgcgg tgaaccgcca ctacatctac     2340

gacacccagg gggcggccat cgccggctcc aacctctgca ccgagatcgt ccatccggcc     2400

tccaagcgat ccagtggggt ctgcaacctg ggaagcgtga atctggcccg atgcgtctcc     2460

aggcagacgt ttgactttgg gcggctccgc gacgccgtgc aggcgtgcgt gctgatggtg     2520

aacatcatga tcgacagcac gctacaaccc acgccccagt gcacccgcgg caacgacaac     2580

ctgcggtcca tgggaatcgg catgcagggc ctgcacacgg cctgcctgaa gctggggctg     2640

gatctggagt ctgccgaatt tcaggacctg aacaaacaca tcgccgaggt gatgctgctg     2700

tcggcgatga agaccagcaa cgcgctgtgc gttcgcgggg cccgtccctt caaccacttt     2760

aagcgcagca tgtatcgcgc cggccgcttt cactgggagc gctttccgga cgcccggccg     2820

cggtacgagg gcgagtggga gatgctacgc cagagcatga tgaaacacgg cctgcgcaac     2880

agccagtttg tcgcgctgat gcccaccgcc gcctcggcgc agatctcgga cgtcagcgag     2940

ggctttgccc ccctgttcac caacctgttc agcaaggtga cccgggacgg cgagacgctg     3000

cgccccaaca cgctcctgct aaaggaactg gaacgcacgt ttagcgggaa gcgcctcctg     3060

gaggtgatgg acagtctcga cgccaagcag tggtccgtgg cgcaggcgct cccgtgcctg     3120

gagcccaccc accccctccg gcgattcaag accgcgtttg actacgacca gaagttgctg     3180

atcgacctgt gtgcggaccg cgccccctac gtcgaccata gccaatccat gaccctgtat     3240

gtcacggaga aggcggacgg gaccctccca gcctccaccc tggtccgcct tctggtccac     3300

gcatataagc gcggactaaa aacagggatg tactactgca aggttcgcaa ggcgaccaac     3360

agcggggtct ttggcggcga cgacaacatt gtctgcatga gctgcgcgct gtga           3414


<210>  46
<211>  1137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  46

Met Ala Ser Arg Pro Ala Ala Ser Ser Pro Val Glu Ala Arg Ala Pro 
1               5                   10                  15      


Val Gly Gly Gln Glu Ala Gly Gly Pro Ser Ala Ala Thr Gln Gly Glu 
            20                  25                  30          


Ala Ala Gly Ala Pro Leu Ala His Gly His His Val Tyr Cys Gln Arg 
        35                  40                  45              


Val Asn Gly Val Met Val Leu Ser Asp Lys Thr Pro Gly Ser Ala Ser 
    50                  55                  60                  


Tyr Arg Ile Ser Asp Ser Asn Phe Val Gln Cys Gly Ser Asn Cys Thr 
65                  70                  75                  80  


Met Ile Ile Asp Gly Asp Val Val Arg Gly Arg Pro Gln Asp Pro Gly 
                85                  90                  95      


Ala Ala Ala Ser Pro Ala Pro Phe Val Ala Val Thr Asn Ile Gly Ala 
            100                 105                 110         


Gly Ser Asp Gly Gly Thr Ala Val Val Ala Phe Gly Gly Thr Pro Arg 
        115                 120                 125             


Arg Ser Ala Gly Thr Ser Thr Gly Thr Gln Thr Ala Asp Val Pro Thr 
    130                 135                 140                 


Glu Ala Leu Gly Gly Pro Pro Pro Pro Pro Arg Phe Thr Leu Gly Gly 
145                 150                 155                 160 


Gly Cys Cys Ser Cys Arg Asp Thr Arg Arg Arg Ser Ala Val Phe Gly 
                165                 170                 175     


Gly Glu Gly Asp Pro Val Gly Pro Ala Glu Phe Val Ser Asp Asp Arg 
            180                 185                 190         


Ser Ser Asp Ser Asp Ser Asp Asp Ser Glu Asp Thr Asp Ser Glu Thr 
        195                 200                 205             


Leu Ser His Ala Ser Ser Asp Val Ser Gly Gly Ala Thr Tyr Asp Asp 
    210                 215                 220                 


Ala Leu Asp Ser Asp Ser Ser Ser Asp Asp Ser Leu Gln Ile Asp Gly 
225                 230                 235                 240 


Pro Val Cys Arg Pro Trp Ser Asn Asp Thr Ala Pro Leu Asp Val Cys 
                245                 250                 255     


Pro Gly Thr Pro Gly Pro Gly Ala Asp Ala Gly Gly Pro Ser Ala Val 
            260                 265                 270         


Asp Pro His Ala Pro Thr Pro Glu Ala Gly Ala Gly Leu Ala Ala Asp 
        275                 280                 285             


Pro Ala Val Ala Arg Asp Asp Ala Glu Gly Leu Ser Asp Pro Arg Pro 
    290                 295                 300                 


Arg Leu Gly Thr Gly Thr Ala Tyr Pro Val Pro Leu Glu Leu Thr Pro 
305                 310                 315                 320 


Glu Asn Ala Glu Ala Val Ala Arg Phe Leu Gly Asp Ala Val Asn Arg 
                325                 330                 335     


Glu Pro Ala Leu Met Leu Glu Tyr Phe Cys Arg Cys Ala Arg Glu Glu 
            340                 345                 350         


Thr Lys Arg Val Pro Pro Arg Thr Phe Gly Ser Pro Pro Arg Leu Thr 
        355                 360                 365             


Glu Asp Asp Phe Gly Leu Leu Asn Tyr Ala Leu Val Glu Met Gln Arg 
    370                 375                 380                 


Leu Cys Leu Asp Val Pro Pro Val Pro Pro Asn Ala Tyr Met Pro Tyr 
385                 390                 395                 400 


Tyr Leu Arg Glu Tyr Val Thr Arg Leu Val Asn Gly Phe Lys Pro Leu 
                405                 410                 415     


Val Ser Arg Ser Ala Arg Leu Tyr Arg Ile Leu Gly Val Leu Val His 
            420                 425                 430         


Leu Arg Ile Arg Thr Arg Glu Ala Ser Phe Glu Glu Trp Leu Arg Ser 
        435                 440                 445             


Lys Glu Val Ala Leu Asp Phe Gly Leu Thr Glu Arg Leu Arg Glu His 
    450                 455                 460                 


Glu Ala Gln Leu Val Ile Leu Ala Gln Ala Leu Asp His Tyr Asp Cys 
465                 470                 475                 480 


Leu Ile His Ser Thr Pro His Thr Leu Val Glu Arg Gly Leu Gln Ser 
                485                 490                 495     


Ala Leu Lys Tyr Glu Glu Phe Tyr Leu Lys Arg Phe Gly Gly His Tyr 
            500                 505                 510         


Met Glu Ser Val Phe Gln Met Tyr Thr Arg Ile Ala Gly Phe Leu Ala 
        515                 520                 525             


Cys Arg Ala Thr Arg Gly Met Arg His Ile Ala Leu Gly Arg Glu Gly 
    530                 535                 540                 


Ser Trp Trp Glu Met Phe Lys Phe Phe Phe His Arg Leu Tyr Asp His 
545                 550                 555                 560 


Gln Ile Val Pro Ser Thr Pro Ala Met Leu Asn Leu Gly Thr Arg Asn 
                565                 570                 575     


Tyr Tyr Thr Ser Ser Cys Tyr Leu Val Asn Pro Gln Ala Thr Thr Asn 
            580                 585                 590         


Lys Ala Thr Leu Arg Ala Ile Thr Ser Asn Val Ser Ala Ile Leu Ala 
        595                 600                 605             


Arg Asn Gly Gly Ile Gly Leu Cys Val Gln Ala Phe Asn Asp Ser Gly 
    610                 615                 620                 


Pro Gly Thr Ala Ser Val Met Pro Ala Leu Lys Val Leu Asp Ser Leu 
625                 630                 635                 640 


Val Ala Ala His Asn Lys Glu Ser Ala Arg Pro Thr Gly Ala Cys Val 
                645                 650                 655     


Tyr Leu Glu Pro Trp His Thr Asp Val Arg Ala Val Leu Arg Met Lys 
            660                 665                 670         


Gly Val Leu Ala Gly Glu Glu Ala Gln Arg Cys Asp Asn Ile Phe Ser 
        675                 680                 685             


Ala Leu Trp Met Pro Asp Leu Phe Phe Lys Arg Leu Ile Arg His Leu 
    690                 695                 700                 


Asp Gly Glu Lys Asn Val Thr Trp Thr Leu Phe Asp Arg Asp Thr Ser 
705                 710                 715                 720 


Met Ser Leu Ala Asp Phe His Gly Glu Glu Phe Glu Lys Leu Tyr Gln 
                725                 730                 735     


His Leu Glu Val Met Gly Phe Gly Glu Gln Ile Pro Ile Gln Glu Leu 
            740                 745                 750         


Ala Tyr Gly Ile Val Arg Ser Ala Ala Thr Thr Gly Ser Pro Phe Val 
        755                 760                 765             


Met Phe Lys Asp Ala Val Asn Arg His Tyr Ile Tyr Asp Thr Gln Gly 
    770                 775                 780                 


Ala Ala Ile Ala Gly Ser Asn Leu Cys Thr Glu Ile Val His Pro Ala 
785                 790                 795                 800 


Ser Lys Arg Ser Ser Gly Val Cys Asn Leu Gly Ser Val Asn Leu Ala 
                805                 810                 815     


Arg Cys Val Ser Arg Gln Thr Phe Asp Phe Gly Arg Leu Arg Asp Ala 
            820                 825                 830         


Val Gln Ala Cys Val Leu Met Val Asn Ile Met Ile Asp Ser Thr Leu 
        835                 840                 845             


Gln Pro Thr Pro Gln Cys Thr Arg Gly Asn Asp Asn Leu Arg Ser Met 
    850                 855                 860                 


Gly Ile Gly Met Gln Gly Leu His Thr Ala Cys Leu Lys Leu Gly Leu 
865                 870                 875                 880 


Asp Leu Glu Ser Ala Glu Phe Gln Asp Leu Asn Lys His Ile Ala Glu 
                885                 890                 895     


Val Met Leu Leu Ser Ala Met Lys Thr Ser Asn Ala Leu Cys Val Arg 
            900                 905                 910         


Gly Ala Arg Pro Phe Asn His Phe Lys Arg Ser Met Tyr Arg Ala Gly 
        915                 920                 925             


Arg Phe His Trp Glu Arg Phe Pro Asp Ala Arg Pro Arg Tyr Glu Gly 
    930                 935                 940                 


Glu Trp Glu Met Leu Arg Gln Ser Met Met Lys His Gly Leu Arg Asn 
945                 950                 955                 960 


Ser Gln Phe Val Ala Leu Met Pro Thr Ala Ala Ser Ala Gln Ile Ser 
                965                 970                 975     


Asp Val Ser Glu Gly Phe Ala Pro Leu Phe Thr Asn Leu Phe Ser Lys 
            980                 985                 990         


Val Thr Arg Asp Gly Glu Thr Leu  Arg Pro Asn Thr Leu  Leu Leu Lys 
        995                 1000                 1005             


Glu Leu  Glu Arg Thr Phe Ser  Gly Lys Arg Leu Leu  Glu Val Met 
    1010                 1015                 1020             


Asp Ser  Leu Asp Ala Lys Gln  Trp Ser Val Ala Gln  Ala Leu Pro 
    1025                 1030                 1035             


Cys Leu  Glu Pro Thr His Pro  Leu Arg Arg Phe Lys  Thr Ala Phe 
    1040                 1045                 1050             


Asp Tyr  Asp Gln Lys Leu Leu  Ile Asp Leu Cys Ala  Asp Arg Ala 
    1055                 1060                 1065             


Pro Tyr  Val Asp His Ser Gln  Ser Met Thr Leu Tyr  Val Thr Glu 
    1070                 1075                 1080             


Lys Ala  Asp Gly Thr Leu Pro  Ala Ser Thr Leu Val  Arg Leu Leu 
    1085                 1090                 1095             


Val His  Ala Tyr Lys Arg Gly  Leu Lys Thr Gly Met  Tyr Tyr Cys 
    1100                 1105                 1110             


Lys Val  Arg Lys Ala Thr Asn  Ser Gly Val Phe Gly  Gly Asp Asp 
    1115                 1120                 1125             


Asn Ile  Val Cys Met Ser Cys  Ala Leu 
    1130                 1135         


<210>  47
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  47
gaaccccttc gccatggagc ccagtatctt gctcctcctt gctctccttg tgggcttctt       60

gttactctta gtcaggggac acccaaagtc ccgtggcaac ttcccaccag gacctcgtcc      120

ccttcccctc ttggggaacc tcctgcagtt ggacagaggg ggcctcctca attccttcat      180

gcagcttcga gaaaaatatg gagatgtgtt cacagtacac ctgggaccaa ggcctgtggt      240

catgctatgt gggacagaca ccataaagga ggctctggtg ggccaagctg aggatttctc      300

tggtcgggga acaatcgctg tgattgagcc aatcttcaag gaatatggtg tgatctttgc      360

caatggggaa cgctggaagg cccttcggcg attctctctg gctaccatga gagactttgg      420

gatgggaaag aggagtgtgg aagaacggat tcaggaggaa gcccaatgtt tggtggagga      480

actgcggaaa tcccagggag ccccactgga tcccaccttc ctcttccagt gcatcacagc      540

caacatcatc tgctccattg tgtttggaga gcgctttgac tacacagacc gccagttcct      600

gcgcctgttg gagctgttct accggacctt ttccctccta agttcattct ccagccaggt      660

gtttgagttc ttctctgggt tcctgaaata ctttcctggt gcccacagac aaatctccaa      720

aaacctccag gaaatcctcg attacattgg ccatattgtg gagaagcaca gggccacctt      780

agacccaagc gctccacgag acttcatcga cacttacctt ctgcgcatgg agaaggagaa      840

gtcgaaccac cacacagagt tccatcatga gaacctcatg atctccctgc tctctctctt      900

ctttgctggc actgagacca gcagcaccac actccgctat ggtttcctgc tgatgctcaa      960

gtacccccat gtcgcagaga aagtccaaaa ggagattgat caggtgatcg gctcacaccg     1020

gctaccaacc cttgatgacc gcagtaaaat gccatacact gatgcagtta tccatgagat     1080

tcagaggttt tcagatcttg tccctattgg agtaccacac agagtcacca aagacaccat     1140

gttccgaggg tacctgcttc ccaagaacac tgaagtgtac cccatcctga gttcagctct     1200

ccatgaccca cagtactttg accacccaga cagcttcaat cctgaacact tcctggatgc     1260

caatggggca ctgaaaaaga gtgaagcttt catgcccttc tccacaggaa agcgcatttg     1320

tcttggcgaa ggcattgccc gaaatgaatt gttcctcttc ttcaccacca tcctccagaa     1380

cttctctgtg tcaagccatt tggctcccaa ggacattgac ctcacgccca aggagagtgg     1440

cattggaaaa atacctccaa cgtaccagat ctgcttctca gctcggtgat ccggctgagg     1500

cagccatgtg ccccagttct gttgggaatg gaacttgttt attgcagctt ataatggtta     1560

caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag     1620

ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatccccg ggcgagctcg     1680

aattcctcct ttgaggagtg gctgcgatcc aaggaagtgg ccctggactt tggcctgacg     1740

gaaaggcttc gcgagcacga agcccagctg gtgatcctgg cccaggctct ggaccattac     1800

gactgtctga tccacagcac accgcacacg ctggtcgagc gggggctgca atcggccctg     1860

aagtatgagg agttttacct aaagcgcttt ggcgggcact acatggagtc cgtcttccag     1920

atgtacaccc gcatcgccgg ctttttggcc tgccgggcca cgcgcggcat gcgccacatc     1980

gccctggggc gagaggggtc gtggtgggaa atgttcaagt tctttttcca ccgcctctac     2040

gaccaccaga tcgtaccgtc gacccccgcc atgctgaacc tggggacccg caactactac     2100

acctccagct gctacctggt aaacccccag gccaccacaa acaaggcgac cctgcgggcc     2160

atcaccagca acgtcagcgc catcctcgcc cgcaacgggg gcatcgggct atgcgtgcag     2220

gcgtttaacg actccggccc cgggaccgct agcgtcatac ccgccctcaa ggtcctcgac     2280

tcgctggtgg cggcgcacaa caaagagagc gcgcgtccaa ccggcgcgtg cgtgtacctg     2340

gagccgtggc acaccgacgt gcgggccgtg ctccggatga agggggtcct cgccggcgaa     2400

gaggcccagc gctgcgacaa tatcttcagc gccctctgga tgccagacct gtttttcaag     2460

cgcctgattc gccacctgga cggcgagaag aacgtcacat ggaccctgtt cgaccgggac     2520

accagcatgt cgctcgccga ctttcacggg gaggagttcg agaagctcta ccagcacctc     2580

gaggtcatgg ggttcggcga gcagataccc atccaggagc tggcctatgg cattgtgcgc     2640

agtgcggcca cgaccgggag ccccttcgtc atgttcaaag acgcggtgaa ccgccactac     2700

atctacgaca cccagggggc ggccatcgcc ggctccaacc tctgcaccga gatcgtccat     2760

ccggcctcca agcgatccag tggggtctgc aatctgggaa gcgtgaatct ggcccgatgc     2820

gtctccaggc agacgtttga ctttgggcgg ctccgcgacg ccgtgcaggc gtgcgtgctg     2880

atggtgaaca tcatgatcga cagcacgcta caacccacgc cccagtgcac ccgcggcaac     2940

gacaacctgc ggtccatggg aatcggcatg cagggcctgc acacggcctg cctgaagctg     3000

gggctggatc tggagtctgt cgaatttcag gacctgaaca aacacatcgc cgaggtgatg     3060

ctgctgtcgg cgatgaagac cagcaacgcg ctgtgcgttc gcggggcccg tcccttcaac     3120

cactttaagc gcagcatgta tcgcgccggc cgctttcact gggagcgctt tccggacgcc     3180

cggccgcggt acgagggcga gtgggagatg ctacgccaga gcatgatgaa acacggcctg     3240

cgcaacagcc agtttgtcgc gctgatgccc accgccgcct cggcgcagat ctcggacgtc     3300

agcgagggct ttgcccccct gttcaccaac ctgttcagca aggtgacccg ggacggcgag     3360

acgctgcgcc ccaacacgct cctgctaaag gaactggaac gcacgtttag cgggaagcgc     3420

ctcctggagg tgatggacag tctcgacgcc aagcagtggt ccgtggcgca ggcgctcccg     3480

tgcctggagc ccacccaccc cctccggcga ttcaagaccg cgtttgacta cgaccagaag     3540

ttgctgatcg acctgtgtgc ggaccgcgcc ccctacgtcg accatagcca atccatgacc     3600

ctgtatgtca cggagaaggc ggacgggacc ctcccagcct ccaccctggt ccgccttctg     3660

gtccacgcat ataagcgcgg actaaaaaca gggatgtact actgcaaggt tcgcaaggcg     3720

accaacagcg gggtctttgg cggcgacgac aacattgtct gcacgagctg cgcgctgtga     3780


<210>  48
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  48

Met Glu Pro Ser Ile Leu Leu Leu Leu Ala Leu Leu Val Gly Phe Leu 
1               5                   10                  15      


Leu Leu Leu Val Arg Gly His Pro Lys Ser Arg Gly Asn Phe Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Leu Asp Arg 
        35                  40                  45              


Gly Gly Leu Leu Asn Ser Phe Met Gln Leu Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Thr Asp Thr Ile Lys Glu Ala Leu Val Gly Gln Ala Glu Asp Phe Ser 
                85                  90                  95      


Gly Arg Gly Thr Ile Ala Val Ile Glu Pro Ile Phe Lys Glu Tyr Gly 
            100                 105                 110         


Val Ile Phe Ala Asn Gly Glu Arg Trp Lys Ala Leu Arg Arg Phe Ser 
        115                 120                 125             


Leu Ala Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Val Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Gln Gly Ala Pro Leu Asp Pro Thr Phe Leu Phe Gln Cys Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Glu Arg Phe Asp Tyr Thr Asp 
            180                 185                 190         


Arg Gln Phe Leu Arg Leu Leu Glu Leu Phe Tyr Arg Thr Phe Ser Leu 
        195                 200                 205             


Leu Ser Ser Phe Ser Ser Gln Val Phe Glu Phe Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Ile Ser Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Leu Asp Tyr Ile Gly His Ile Val Glu Lys His Arg Ala Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Arg Asp Phe Ile Asp Thr Tyr Leu Leu Arg Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn His His Thr Glu Phe His His Glu Asn Leu 
        275                 280                 285             


Met Ile Ser Leu Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Ser Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Lys Val Gln Lys Glu Ile Asp Gln Val Ile Gly Ser His Arg 
                325                 330                 335     


Leu Pro Thr Leu Asp Asp Arg Ser Lys Met Pro Tyr Thr Asp Ala Val 
            340                 345                 350         


Ile His Glu Ile Gln Arg Phe Ser Asp Leu Val Pro Ile Gly Val Pro 
        355                 360                 365             


His Arg Val Thr Lys Asp Thr Met Phe Arg Gly Tyr Leu Leu Pro Lys 
    370                 375                 380                 


Asn Thr Glu Val Tyr Pro Ile Leu Ser Ser Ala Leu His Asp Pro Gln 
385                 390                 395                 400 


Tyr Phe Asp His Pro Asp Ser Phe Asn Pro Glu His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Ser Glu Ala Phe Met Pro Phe Ser Thr Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Asn Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Val Ser Ser His Leu Ala 
    450                 455                 460                 


Pro Lys Asp Ile Asp Leu Thr Pro Lys Glu Ser Gly Ile Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Cys Phe Ser Ala Arg 
                485                 490     


<210>  49
<211>  3414
<212>  DNA
<213>  Herpes simplex virus type 1

<400>  49
atggccagcc gcccagccgc atcctctccc gtcgaagcgc gggccccggt tgggggacag       60

gaggccggcg gccccagcgc agccacccag ggggaggccg ccggggcccc tctcgcccac      120

ggccaccacg tgtactgcca gcgagtcaat ggcgtgatgg tgctttccga caagacgccc      180

gggtccgcgt cctaccgcat cagcgatagc aactttgtcc aatgtggttc caactgcacc      240

atgatcatcg acggagacgt ggtgcgcggg cgcccccagg acccgggggc cgcggcatcc      300

cccgctccct tcgttgcggt gacaaacatc ggagccggca gcgacggcgg gaccgccgtc      360

gtggcattcg ggggaacccc acgtcgctcg gcggggacgt ctaccggtac ccagacggcc      420

gacgtcccca ccgaggccct tgggggcccc cctcctcctc cccgcttcac cctgggtggc      480

ggctgttgtt cctgtcgcga cacacggcgc cgctctgcgg tattcggggg ggagggggat      540

ccagtcggcc ccgcggagtt cgtctcggac gaccggtcgt ccgattccga ctcggatgac      600

tcggaggaca cggactcgga gacgctgtca cacgcctcct cggacgtgtc cggcggggcc      660

acgtacgacg acgcccttga ctccgattcg tcatcggatg actccctgca gatagatggc      720

cccgtgtgtc gcccgtggag caatgacacc gcgcccctgg atgtttgccc cgggaccccc      780

ggcccgggcg ccgacgccgg tggtccctca gcggtagacc cacacgcgcc gacgccagag      840

gccggcgctg gtcttgcggc cgatcccgcc gtggcccggg acgacgcgga ggggctttcg      900

gacccccggc cacgtctggg aacgggcacg gcctaccccg tccccctgga actcacgccc      960

gagaacgcgg aggccgtggc gcgctttctg ggagatgccg tgaaccgcga acccgcgctc     1020

atgctggagt acttttgccg gtgcgcccgc gaggaaacca agcgtgtccc ccccaggaca     1080

ttcggcagcc cccctcgcct cacggaggac gactttgggc ttctcaacta cgcgctcgtg     1140

gagatgcagc gcctgtgtct ggacgttcct ccggtcccgc cgaacgcata catgccctat     1200

tatctcaggg agtatgtgac gcggctggtc aacgggttca agccgctggt gagccggtcc     1260

gctcgccttt accgcatcct gggggttctg gtgcacctgc ggatccggac ccgggaggcc     1320

tcctttgagg agtggctgcg atccaaggaa gtggccctgg attttggcct gacggaaagg     1380

cttcgcgagc acgaagccca gctggtgatc ctggcccagg ctctggacca ttacgactgt     1440

ctgatccaca gcacaccgca cacgctggtc gagcgggggc tgcaatcggc cctgaagtat     1500

gaggagtttt acctaaagcg ttttggcggg cactacatgg agtccgtctt ccagatgtac     1560

acccgcatcg ccggcttttt ggcctgccgg gccacgcgcg gcatgcgcca catcgccctg     1620

gggcgagagg ggtcgtggtg ggaaatgttc aagttctttt tccaccgcct ctacgaccac     1680

cagatcgtac cgtcgacccc cgccatgctg aacctgggga cccgcaacta ctacacctcc     1740

agctgctacc tggtaaaccc ccaggccacc acaaacaagg cgaccctgcg ggccatcacc     1800

agcaacgtca gtgccatcct cgcccgcaac gggggcatcg ggctatgcgt gcaggcgttt     1860

aacgactccg gccccgggac cgccagcgtc atgcccgccc tcaaggtcct tgactcgctg     1920

gtggcggcgc acaacaaaga gagcgcgcgt ccgaccggcg cgtgcgtgta cctggagccg     1980

tggcacaccg acgtgcgggc cgtgctccgg atgaaggggg tcctcgccgg cgaagaggcc     2040

cagcgctgcg acaatatctt cagcgccctc tggatgccag acctgttttt caagcgcctg     2100

attcgccacc tggacggcga gaagaacgtc acatggaccc tgttcgaccg ggacaccagc     2160

atgtcgctcg ccgactttca cggggaggag ttcgagaagc tctaccagca cctcgaggtc     2220

atggggttcg gcgagcagat acccatccag gagctggcct atggcattgt gcgcagtgcg     2280

gccacgaccg ggagcccctt cgtcatgttc aaagacgcgg tgaaccgcca ctacatctac     2340

gacacccagg gggcggccat cgccggctcc aacctctgca ccgagatcgt ccatccggcc     2400

tccaagcgat ccagtggggt ctgcaacctg ggaagcgtga atctggcccg atgcgtctcc     2460

aggcagacgt ttgactttgg gcggctccgc gacgccgtgc aggcgtgcgt gctgatggtg     2520

aacatcatga tcgacagcac gctacaaccc acgccccagt gcacccgcgg caacgacaac     2580

ctgcggtcca tgggaatcgg catgcagggc ctgcacacgg cctgcctgaa gctggggctg     2640

gatctggagt ctgtcgaatt tcaggacctg aacaaacaca tcgccgaggt gatgctgctg     2700

tcggcgatga agaccagcaa cgcgctgtgc gttcgcgggg cccgtccctt caaccacttt     2760

aagcgcagca tgtatcgcgc cggccgcttt cactgggagc gctttccgga cgcccggccg     2820

cggtacgagg gcgagtggga gatgctacgc cagagcatga tgaaacacgg cctgcgcaac     2880

agccagtttg tcgcgctgat gcccaccgcc gcctcggcgc agatctcgga cgtcagcgag     2940

ggctttgccc ccctgttcac caacctgttc agcaaggtga cccgggacgg cgagacgctg     3000

cgccccaaca cgctcctgct aaaggaactg gaacgcacgt ttagcgggaa gcgcctcctg     3060

gaggtgatgg acagtctcga cgccaagcag tggtccgtgg cgcaggcgct cccgtgcctg     3120

gagcccaccc accccctccg gcgattcaag accgcgtttg actacgacca gaagttgctg     3180

atcgacctgt gtgcggaccg cgccccctac gtcgaccata gccaatccat gaccctgtat     3240

gtcacggaga aggcggacgg gaccctccca gcctccaccc tggtccgcct tctggtccac     3300

gcatataagc gcggactaaa aacagggatg tactactgca aggttcgcaa ggcgaccaac     3360

agcggggtct ttggcggcga cgacaacatt gtctgcacga gctgcgcgct gtga           3414


<210>  50
<211>  1137
<212>  PRT
<213>  Herpes simplex virus type 1

<400>  50

Met Ala Ser Arg Pro Ala Ala Ser Ser Pro Val Glu Ala Arg Ala Pro 
1               5                   10                  15      


Val Gly Gly Gln Glu Ala Gly Gly Pro Ser Ala Ala Thr Gln Gly Glu 
            20                  25                  30          


Ala Ala Gly Ala Pro Leu Ala His Gly His His Val Tyr Cys Gln Arg 
        35                  40                  45              


Val Asn Gly Val Met Val Leu Ser Asp Lys Thr Pro Gly Ser Ala Ser 
    50                  55                  60                  


Tyr Arg Ile Ser Asp Ser Asn Phe Val Gln Cys Gly Ser Asn Cys Thr 
65                  70                  75                  80  


Met Ile Ile Asp Gly Asp Val Val Arg Gly Arg Pro Gln Asp Pro Gly 
                85                  90                  95      


Ala Ala Ala Ser Pro Ala Pro Phe Val Ala Val Thr Asn Ile Gly Ala 
            100                 105                 110         


Gly Ser Asp Gly Gly Thr Ala Val Val Ala Phe Gly Gly Thr Pro Arg 
        115                 120                 125             


Arg Ser Ala Gly Thr Ser Thr Gly Thr Gln Thr Ala Asp Val Pro Thr 
    130                 135                 140                 


Glu Ala Leu Gly Gly Pro Pro Pro Pro Pro Arg Phe Thr Leu Gly Gly 
145                 150                 155                 160 


Gly Cys Cys Ser Cys Arg Asp Thr Arg Arg Arg Ser Ala Val Phe Gly 
                165                 170                 175     


Gly Glu Gly Asp Pro Val Gly Pro Ala Glu Phe Val Ser Asp Asp Arg 
            180                 185                 190         


Ser Ser Asp Ser Asp Ser Asp Asp Ser Glu Asp Thr Asp Ser Glu Thr 
        195                 200                 205             


Leu Ser His Ala Ser Ser Asp Val Ser Gly Gly Ala Thr Tyr Asp Asp 
    210                 215                 220                 


Ala Leu Asp Ser Asp Ser Ser Ser Asp Asp Ser Leu Gln Ile Asp Gly 
225                 230                 235                 240 


Pro Val Cys Arg Pro Trp Ser Asn Asp Thr Ala Pro Leu Asp Val Cys 
                245                 250                 255     


Pro Gly Thr Pro Gly Pro Gly Ala Asp Ala Gly Gly Pro Ser Ala Val 
            260                 265                 270         


Asp Pro His Ala Pro Thr Pro Glu Ala Gly Ala Gly Leu Ala Ala Asp 
        275                 280                 285             


Pro Ala Val Ala Arg Asp Asp Ala Glu Gly Leu Ser Asp Pro Arg Pro 
    290                 295                 300                 


Arg Leu Gly Thr Gly Thr Ala Tyr Pro Val Pro Leu Glu Leu Thr Pro 
305                 310                 315                 320 


Glu Asn Ala Glu Ala Val Ala Arg Phe Leu Gly Asp Ala Val Asn Arg 
                325                 330                 335     


Glu Pro Ala Leu Met Leu Glu Tyr Phe Cys Arg Cys Ala Arg Glu Glu 
            340                 345                 350         


Thr Lys Arg Val Pro Pro Arg Thr Phe Gly Ser Pro Pro Arg Leu Thr 
        355                 360                 365             


Glu Asp Asp Phe Gly Leu Leu Asn Tyr Ala Leu Val Glu Met Gln Arg 
    370                 375                 380                 


Leu Cys Leu Asp Val Pro Pro Val Pro Pro Asn Ala Tyr Met Pro Tyr 
385                 390                 395                 400 


Tyr Leu Arg Glu Tyr Val Thr Arg Leu Val Asn Gly Phe Lys Pro Leu 
                405                 410                 415     


Val Ser Arg Ser Ala Arg Leu Tyr Arg Ile Leu Gly Val Leu Val His 
            420                 425                 430         


Leu Arg Ile Arg Thr Arg Glu Ala Ser Phe Glu Glu Trp Leu Arg Ser 
        435                 440                 445             


Lys Glu Val Ala Leu Asp Phe Gly Leu Thr Glu Arg Leu Arg Glu His 
    450                 455                 460                 


Glu Ala Gln Leu Val Ile Leu Ala Gln Ala Leu Asp His Tyr Asp Cys 
465                 470                 475                 480 


Leu Ile His Ser Thr Pro His Thr Leu Val Glu Arg Gly Leu Gln Ser 
                485                 490                 495     


Ala Leu Lys Tyr Glu Glu Phe Tyr Leu Lys Arg Phe Gly Gly His Tyr 
            500                 505                 510         


Met Glu Ser Val Phe Gln Met Tyr Thr Arg Ile Ala Gly Phe Leu Ala 
        515                 520                 525             


Cys Arg Ala Thr Arg Gly Met Arg His Ile Ala Leu Gly Arg Glu Gly 
    530                 535                 540                 


Ser Trp Trp Glu Met Phe Lys Phe Phe Phe His Arg Leu Tyr Asp His 
545                 550                 555                 560 


Gln Ile Val Pro Ser Thr Pro Ala Met Leu Asn Leu Gly Thr Arg Asn 
                565                 570                 575     


Tyr Tyr Thr Ser Ser Cys Tyr Leu Val Asn Pro Gln Ala Thr Thr Asn 
            580                 585                 590         


Lys Ala Thr Leu Arg Ala Ile Thr Ser Asn Val Ser Ala Ile Leu Ala 
        595                 600                 605             


Arg Asn Gly Gly Ile Gly Leu Cys Val Gln Ala Phe Asn Asp Ser Gly 
    610                 615                 620                 


Pro Gly Thr Ala Ser Val Met Pro Ala Leu Lys Val Leu Asp Ser Leu 
625                 630                 635                 640 


Val Ala Ala His Asn Lys Glu Ser Ala Arg Pro Thr Gly Ala Cys Val 
                645                 650                 655     


Tyr Leu Glu Pro Trp His Thr Asp Val Arg Ala Val Leu Arg Met Lys 
            660                 665                 670         


Gly Val Leu Ala Gly Glu Glu Ala Gln Arg Cys Asp Asn Ile Phe Ser 
        675                 680                 685             


Ala Leu Trp Met Pro Asp Leu Phe Phe Lys Arg Leu Ile Arg His Leu 
    690                 695                 700                 


Asp Gly Glu Lys Asn Val Thr Trp Thr Leu Phe Asp Arg Asp Thr Ser 
705                 710                 715                 720 


Met Ser Leu Ala Asp Phe His Gly Glu Glu Phe Glu Lys Leu Tyr Gln 
                725                 730                 735     


His Leu Glu Val Met Gly Phe Gly Glu Gln Ile Pro Ile Gln Glu Leu 
            740                 745                 750         


Ala Tyr Gly Ile Val Arg Ser Ala Ala Thr Thr Gly Ser Pro Phe Val 
        755                 760                 765             


Met Phe Lys Asp Ala Val Asn Arg His Tyr Ile Tyr Asp Thr Gln Gly 
    770                 775                 780                 


Ala Ala Ile Ala Gly Ser Asn Leu Cys Thr Glu Ile Val His Pro Ala 
785                 790                 795                 800 


Ser Lys Arg Ser Ser Gly Val Cys Asn Leu Gly Ser Val Asn Leu Ala 
                805                 810                 815     


Arg Cys Val Ser Arg Gln Thr Phe Asp Phe Gly Arg Leu Arg Asp Ala 
            820                 825                 830         


Val Gln Ala Cys Val Leu Met Val Asn Ile Met Ile Asp Ser Thr Leu 
        835                 840                 845             


Gln Pro Thr Pro Gln Cys Thr Arg Gly Asn Asp Asn Leu Arg Ser Met 
    850                 855                 860                 


Gly Ile Gly Met Gln Gly Leu His Thr Ala Cys Leu Lys Leu Gly Leu 
865                 870                 875                 880 


Asp Leu Glu Ser Val Glu Phe Gln Asp Leu Asn Lys His Ile Ala Glu 
                885                 890                 895     


Val Met Leu Leu Ser Ala Met Lys Thr Ser Asn Ala Leu Cys Val Arg 
            900                 905                 910         


Gly Ala Arg Pro Phe Asn His Phe Lys Arg Ser Met Tyr Arg Ala Gly 
        915                 920                 925             


Arg Phe His Trp Glu Arg Phe Pro Asp Ala Arg Pro Arg Tyr Glu Gly 
    930                 935                 940                 


Glu Trp Glu Met Leu Arg Gln Ser Met Met Lys His Gly Leu Arg Asn 
945                 950                 955                 960 


Ser Gln Phe Val Ala Leu Met Pro Thr Ala Ala Ser Ala Gln Ile Ser 
                965                 970                 975     


Asp Val Ser Glu Gly Phe Ala Pro Leu Phe Thr Asn Leu Phe Ser Lys 
            980                 985                 990         


Val Thr Arg Asp Gly Glu Thr Leu  Arg Pro Asn Thr Leu  Leu Leu Lys 
        995                 1000                 1005             


Glu Leu  Glu Arg Thr Phe Ser  Gly Lys Arg Leu Leu  Glu Val Met 
    1010                 1015                 1020             


Asp Ser  Leu Asp Ala Lys Gln  Trp Ser Val Ala Gln  Ala Leu Pro 
    1025                 1030                 1035             


Cys Leu  Glu Pro Thr His Pro  Leu Arg Arg Phe Lys  Thr Ala Phe 
    1040                 1045                 1050             


Asp Tyr  Asp Gln Lys Leu Leu  Ile Asp Leu Cys Ala  Asp Arg Ala 
    1055                 1060                 1065             


Pro Tyr  Val Asp His Ser Gln  Ser Met Thr Leu Tyr  Val Thr Glu 
    1070                 1075                 1080             


Lys Ala  Asp Gly Thr Leu Pro  Ala Ser Thr Leu Val  Arg Leu Leu 
    1085                 1090                 1095             


Val His  Ala Tyr Lys Arg Gly  Leu Lys Thr Gly Met  Tyr Tyr Cys 
    1100                 1105                 1110             


Lys Val  Arg Lys Ala Thr Asn  Ser Gly Val Phe Gly  Gly Asp Asp 
    1115                 1120                 1125             


Asn Ile  Val Cys Thr Ser Cys  Ala Leu 
    1130                 1135         


<210>  51
<211>  747
<212>  DNA
<213>  Herpes simplex virus type 1

<400>  51
atggcccgcc gccgccgcca tcgcggcccc cgccgccccc ggccgcccgg gcccacgggc       60

gccgtcccaa ccgcacagtc ccaggtaacc tccacgccca actcggaacc cgcggtcagg      120

agcgcgcccg cggccgcccc gccgccgccc cccgccggtg ggcccccgcc ttcttgttcg      180

ctgctgctgc gccagtggct ccacgttccc gagtccgcgt ccgacgacga cgatgacgac      240

gactggccgg acagcccccc gcccgagccg gcgccagagg cccggcccac cgccgccgcc      300

ccccggcccc ggcccccacc gcccggcgtg ggcccggggg gcggggctga cccctcccac      360

cccccctcgc gccccttccg ccttccgccg cgcctcgccc tccgcctgcg cgtcaccgcg      420

gagcacctgg cgcgcctgcg cctgcgacgc gcgggcgggg agggggcgcc ggagcccccc      480

gcgacccccg cgacccccgc gacccccgcg acccccgcga cccccgcgcg ggtgcgcttc      540

tcgccccacg tccgggtgcg ccacctggtg gtctgggcct cggccgcccg cctggcgcgc      600

cgcggctcgt gggcccgcga gcgggccgac cgggctcggt tccggcgccg ggtggcggag      660

gccgaggcgg tcatcgggcc gtgcctgggg cccgaggccc gtgcccgggc cctggcccgc      720

ggagccggcc cggcgaactc ggtctaa                                          747


<210>  52
<211>  248
<212>  PRT
<213>  Herpes simplex virus type 1

<400>  52

Met Ala Arg Arg Arg Arg His Arg Gly Pro Arg Arg Pro Arg Pro Pro 
1               5                   10                  15      


Gly Pro Thr Gly Ala Val Pro Thr Ala Gln Ser Gln Val Thr Ser Thr 
            20                  25                  30          


Pro Asn Ser Glu Pro Ala Val Arg Ser Ala Pro Ala Ala Ala Pro Pro 
        35                  40                  45              


Pro Pro Pro Ala Gly Gly Pro Pro Pro Ser Cys Ser Leu Leu Leu Arg 
    50                  55                  60                  


Gln Trp Leu His Val Pro Glu Ser Ala Ser Asp Asp Asp Asp Asp Asp 
65                  70                  75                  80  


Asp Trp Pro Asp Ser Pro Pro Pro Glu Pro Ala Pro Glu Ala Arg Pro 
                85                  90                  95      


Thr Ala Ala Ala Pro Arg Pro Arg Pro Pro Pro Pro Gly Val Gly Pro 
            100                 105                 110         


Gly Gly Gly Ala Asp Pro Ser His Pro Pro Ser Arg Pro Phe Arg Leu 
        115                 120                 125             


Pro Pro Arg Leu Ala Leu Arg Leu Arg Val Thr Ala Glu His Leu Ala 
    130                 135                 140                 


Arg Leu Arg Leu Arg Arg Ala Gly Gly Glu Gly Ala Pro Glu Pro Pro 
145                 150                 155                 160 


Ala Thr Pro Ala Thr Pro Ala Thr Pro Ala Thr Pro Ala Thr Pro Ala 
                165                 170                 175     


Arg Val Arg Phe Ser Pro His Val Arg Val Arg His Leu Val Val Trp 
            180                 185                 190         


Ala Ser Ala Ala Arg Leu Ala Arg Arg Gly Ser Trp Ala Arg Glu Arg 
        195                 200                 205             


Ala Asp Arg Ala Arg Phe Arg Arg Arg Val Ala Glu Ala Glu Ala Val 
    210                 215                 220                 


Ile Gly Pro Cys Leu Gly Pro Glu Ala Arg Ala Arg Ala Leu Ala Arg 
225                 230                 235                 240 


Gly Ala Gly Pro Ala Asn Ser Val 
                245             


<210>  53
<211>  3229
<212>  DNA
<213>  Herpes simplex virus type 1


<220>
<221>  Intron
<222>  (58)..(822)
<223>  intron

<220>
<221>  Intron
<222>  (1490)..(1625)
<223>  intron

<400>  53
atggagcccc gccccggagc gagtacccgc cggcctgagg gccgccccca gcgcgaggtg       60

aggggccggg cgccatgtct ggggcgccat attggggggc gccatattgg ggggcgccat      120

gttgggggac ccccgaccct tacactggaa ccggccgcca tgttggggga cccccactca      180

tacacgggag ccgggcgcca tgttggggcg ccatgttagg gggcgtggaa ccccgtgaca      240

ctatatatac agggaccggg ggcgccatgt tagggggtgc ggaaccccct gaccctatat      300

atacagggac cggggtcgcc ctgttggggg tcgccatgtg accccctgac tttatatata      360

cagaccccca acacatacac atggcccctt tgactcagac gcagggcccg gggtcgccgt      420

gggaccccct gactcataca cagagacacg cccccacaac aaacacacag ggaccggggt      480

cgccgtgttg ggggcgtggt ccccactgac tcatacgcag gcccccctta ctcacacgca      540

tctagggggg tggggaggag ccgcccgcca tatttggggg acgccgtggg acccccgact      600

ccggtgcgtc tggagggcgg gagaagaggg aagaagaggg gtcgggatcc aaaggacgga      660

cccagaccac ctttggttgc agaccccttt ctcccccctc ttccgaggcc agcagggggg      720

caggactttg tgaggcgggg gggggagagg gggaactcgt gggtgctgat tgacgcggga      780

aatccccccc cattcttacc cgcccccctt ttttcccctt agcccgcccc ggatgtctgg      840

gtgtttccct gcgaccgaga cctgccggac agcagcgact ctgaggcgga gaccgaagtg      900

ggggggcggg gggacgccga ccaccatgac gacgactccg cctccgaggc ggacagcacg      960

gacacggaac tgttcgagac ggggctgctg gggccgcagg gcgtggatgg gggggcggtc     1020

tcggggggga gccccccccg cgaggaagac cccggcagtt gcgggggcgc cccccctcga     1080

gaggacgggg ggagcgacga gggcgacgtg tgcgccgtgt gcacggatga gatcgcgccc     1140

cacctgcgct gcgacacctt cccgtgcatg caccgcttct gcatcccgtg catgaaaacc     1200

tggatgcaat tgcgcaacac ctgcccgctg tgcaacgcca agctggtgta cctgatagtg     1260

ggcgtgacgc ccagcgggtc gttcagcacc atcccgatcg tgaacgaccc ccagacccgc     1320

atggaggccg aggaggccgt cagggcgggc acggccgtgg actttatctg gacgggcaat     1380

cagcggttcg ccccgcggta cctgaccctg ggggggcaca cggtgagggc cctgtcgccc     1440

acccacccgg agcccaccac ggacgaggat gacgacgacc tggacgacgg tgaggcgggg     1500

ggcggcaagg accctggggg aggaggagga ggaggggggg ggagggagga ataggcgggc     1560

gggcgaggaa agggcgggcc ggggaggggg cgtaacctga tcgcgccccc cgttgtctct     1620

tgcagcagac tacgtaccgc ccgccccccg ccggacgccc cgcgcccccc cacgcagagg     1680

cgccgccgcg ccccccgtga cgggcggggc gtctcacgca gccccccagc cggccgcggc     1740

tcggacagcg cccccctcgg cgcccatcgg gccacacggc agcagtaaca ccaacaccac     1800

caccaacagc agcggcggcg gcggctcccg ccagtcgcga gccgcggcgc cgcggggggc     1860

gtctggcccc tccggggggg ttggggttgg ggttggggtt gttgaagcgg aggcggggcg     1920

gccgaggggc cggacgggcc cccttgtcaa cagacccgcc ccccttgcaa acaacagaga     1980

ccccatagtg atcagcgact cccccccggc ctctccccac aggccccccg cggcgcccat     2040

gccaggctcc gccccccgcc ccgggccccc cgcgtccgcg gccgcgtcgg gacccgcgcg     2100

cccccgcgcg gccgtggccc cgtgcgtgcg agcgccgcct ccggggcccg gcccccgcgc     2160

cccggccccc ggggcggagc cggccgcccg ccccgcggac gcgcgccgtg tgccccagtc     2220

gcactcgtcc ctggctcagg ccgcgaacca agaacagagt ctgtgccggg cgcgtgcgac     2280

ggtggcgcgc ggctcggggg ggccgggcgt ggagggtggg cacgggccct cccgcggcgc     2340

cgccccctcc ggcgccgccc cgctcccctc cgccgcctct gtcgagcagg aggcggcggt     2400

gcgtccgagg aagaggcgcg ggtcgggcca ggaaaacccc tccccccagt ccacgcgtcc     2460

ccccctcgcg ccggcagggg ccaagagggc ggcgacgcac cccccctccg actcagggcc     2520

gggggggcgc ggccagggtg ggcccgggac ccccctgacg tcctcggcgg cctccgcctc     2580

ttcctcctct gcctcttcct cctcggcccc gacccccgcg ggggccgcct cttccgccgc     2640

cggggccgcg tcctcctccg cttccgcctc ctcgggcggg gccgtcggtg ccctgggagg     2700

gagacaagag gaaacctccc tcggcccccg cgctgcttct gggccgcggg ggccgaggaa     2760

gtgtgcccgg aagacgcgcc acgcggagac ttccggggcc gtccccgcgg gcggcctcac     2820

gcgctacctg cccatctcgg gggtctctag cgtggtcgcc ctgtcgcctt acgtgaacaa     2880

gactatcacg ggggactgcc tgcccatcct ggacatggag acggggaaca tcggggcgta     2940

cgtggtcctg gtggaccaga cgggaaacat ggcgacccgg ctgcgggccg cggtccccgg     3000

ctggagccgc cgcaccctgc tccccgagac cgcgggtaac cacgtgatgc cccccgagta     3060

cccgacggcc cccgcgtcgg agtggaacag cctctggatg acccccgtgg ggaacatgct     3120

gttcgaccag ggcaccctag tgggcgccct ggacttccgc agcctgcggt ctcggcaccc     3180

gtggtccggg gagcaggggg cgtcgacccg ggacgaggga aaacaataa                 3229


