                         SEQUENCE LISTING

<110>  University of Virginia Patent Foundation
       Kester, Mark
       Drews, Kelly C.
 
<120>  COMPOSITIONS AND METHODS FOR MODULATING VIRAL INFECTIONS BY 
       REGULATING GLUCOSYLCERAMIDES

<130>  3062/116 PCT

<150>  US 62/915,469
<151>  2019-03-08

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  2291
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (138)..(1748)

<400>  1
ggaattactt gcagggctaa cctagtgcct atagctaagg caggtacctg catccttgtt       60

tttgtttagt ggatcctcta tccttcagag actctggaac ccctgtggtc ttctcttcat      120

ctaatgaccc tgagggg atg gag ttt tca agt cct tcc aga gag gaa tgt         170
                   Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys            
                   1               5                   10                 

ccc aag cct ttg agt agg gta agc atc atg gct ggc agc ctc aca gga        218
Pro Lys Pro Leu Ser Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly           
            15                  20                  25                    

ttg ctt cta ctt cag gca gtg tcg tgg gca tca ggt gcc cgc ccc tgc        266
Leu Leu Leu Leu Gln Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys           
        30                  35                  40                        

atc cct aaa agc ttc ggc tac agc tcg gtg gtg tgt gtc tgc aat gcc        314
Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala           
    45                  50                  55                            

aca tac tgt gac tcc ttt gac ccc ccg acc ttt cct gcc ctt ggt acc        362
Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr           
60                  65                  70                  75            

ttc agc cgc tat gag agt aca cgc agt ggg cga cgg atg gag ctg agt        410
Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser           
                80                  85                  90                

atg ggg ccc atc cag gct aat cac acg ggc aca ggc ctg cta ctg acc        458
Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr           
            95                  100                 105                   

ctg cag cca gaa cag aag ttc cag aaa gtg aag gga ttt gga ggg gcc        506
Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala           
        110                 115                 120                       

atg aca gat gct gct gct ctc aac atc ctt gcc ctg tca ccc cct gcc        554
Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala           
    125                 130                 135                           

caa aat ttg cta ctt aaa tcg tac ttc tct gaa gaa gga atc gga tat        602
Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr           
140                 145                 150                 155           

aac atc atc cgg gta ccc atg gcc agc tgt gac ttc tcc atc cgc acc        650
Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr           
                160                 165                 170               

tac acc tat gca gac acc cct gat gat ttc cag ttg cac aac ttc agc        698
Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser           
            175                 180                 185                   

ctc cca gag gaa gat acc aag ctc aag ata ccc ctg att cac cga gcc        746
Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala           
        190                 195                 200                       

ctg cag ttg gcc cag cgt ccc gtt tca ctc ctt gcc agc ccc tgg aca        794
Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr           
    205                 210                 215                           

tca ccc act tgg ctc aag acc aat gga gcg gtg aat ggg aag ggg tca        842
Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser           
220                 225                 230                 235           

ctc aag gga cag ccc gga gac atc tac cac cag acc tgg gcc aga tac        890
Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr           
                240                 245                 250               

ttt gtg aag ttc ctg gat gcc tat gct gag cac aag tta cag ttc tgg        938
Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp           
            255                 260                 265                   

gca gtg aca gct gaa aat gag cct tct gct ggg ctg ttg agt gga tac        986
Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr           
        270                 275                 280                       

ccc ttc cag tgc ctg ggc ttc acc cct gaa cat cag cga gac ttc att       1034
Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile           
    285                 290                 295                           

gcc cgt gac cta ggt cct acc ctc gcc aac agt act cac cac aat gtc       1082
Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr His His Asn Val           
300                 305                 310                 315           

cgc cta ctc atg ctg gat gac caa cgc ttg ctg ctg ccc cac tgg gca       1130
Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala           
                320                 325                 330               

aag gtg gta ctg aca gac cca gaa gca gct aaa tat gtt cat ggc att       1178
Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile           
            335                 340                 345                   

gct gta cat tgg tac ctg gac ttt ctg gct cca gcc aaa gcc acc cta       1226
Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu           
        350                 355                 360                       

ggg gag aca cac cgc ctg ttc ccc aac acc atg ctc ttt gcc tca gag       1274
Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu           
    365                 370                 375                           

gcc tgt gtg ggc tcc aag ttc tgg gag cag agt gtg cgg cta ggc tcc       1322
Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser           
380                 385                 390                 395           

tgg gat cga ggg atg cag tac agc cac agc atc atc acg aac ctc ctg       1370
Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu           
                400                 405                 410               

tac cat gtg gtc ggc tgg acc gac tgg aac ctt gcc ctg aac ccc gaa       1418
Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu           
            415                 420                 425                   

gga gga ccc aat tgg gtg cgt aac ttt gtc gac agt ccc atc att gta       1466
Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val           
        430                 435                 440                       

gac atc acc aag gac acg ttt tac aaa cag ccc atg ttc tac cac ctt       1514
Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu           
    445                 450                 455                           

ggc cac ttc agc aag ttc att cct gag ggc tcc cag aga gtg ggg ctg       1562
Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu           
460                 465                 470                 475           

gtt gcc agt cag aag aac gac ctg gac gca gtg gca ctg atg cat ccc       1610
Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala Leu Met His Pro           
                480                 485                 490               

gat ggc tct gct gtt gtg gtc gtg cta aac cgc tcc tct aag gat gtg       1658
Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser Ser Lys Asp Val           
            495                 500                 505                   

cct ctt acc atc aag gat cct gct gtg ggc ttc ctg gag aca atc tca       1706
Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser           
        510                 515                 520                       

cct ggc tac tcc att cac acc tac ctg tgg cgt cgc cag tga               1748
Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg Gln                       
    525                 530                 535                           

tggagcagat actcaaggag gcactgggct cagcctgggc attaaaggga cagagtcagc     1808

tcacacgctg tctgtgacta aagagggcac agcagggcca gtgtgagctt acagcgacgt     1868

aagcccaggg gcaatggttt gggtgactca ctttcccctc taggtggtgc caggggctgg     1928

aggcccctag aaaaagatca gtaagcccca gtgtcccccc agcccccatg cttatgtgaa     1988

catgcgctgt gtgctgcttg ctttggaaac tgggcctggg tccaggccta gggtgagctc     2048

actgtccgta caaacacaag atcagggctg agggtaagga aaagaagaga ctaggaaagc     2108

tgggcccaaa actggagact gtttgtcttt cctggagatg cagaactggg cccgtggagc     2168

agcagtgtca gcatcagggc ggaagcctta aagcagcagc gggtgtgccc aggcacccag     2228

atgattccta tggcaccagc caggaaaaat ggcagctctt aaaggagaaa atgtttgagc     2288

cca                                                                   2291


<210>  2
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  3
<211>  2344
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (191)..(1801)

<400>  3
atcctgcctt cagagtctta ctgcgcgggg ccccagtctc cagtcccgcc caggcgcctt       60

tgcaggctgc ggtgggattt cgttttgcct ccggttgggg ctgctgtttc tcttcgccga      120

cgtggatcct ctatccttca gagactctgg aacccctgtg gtcttctctt catctaatga      180

ccctgagggg atg gag ttt tca agt cct tcc aga gag gaa tgt ccc aag         229
           Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys            
           1               5                   10                         

cct ttg agt agg gta agc atc atg gct ggc agc ctc aca gga ttg ctt        277
Pro Leu Ser Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu           
    15                  20                  25                            

cta ctt cag gca gtg tcg tgg gca tca ggt gcc cgc ccc tgc atc cct        325
Leu Leu Gln Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro           
30                  35                  40                  45            

aaa agc ttc ggc tac agc tcg gtg gtg tgt gtc tgc aat gcc aca tac        373
Lys Ser Phe Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr           
                50                  55                  60                

tgt gac tcc ttt gac ccc ccg acc ttt cct gcc ctt ggt acc ttc agc        421
Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser           
            65                  70                  75                    

cgc tat gag agt aca cgc agt ggg cga cgg atg gag ctg agt atg ggg        469
Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly           
        80                  85                  90                        

ccc atc cag gct aat cac acg ggc aca ggc ctg cta ctg acc ctg cag        517
Pro Ile Gln Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln           
    95                  100                 105                           

cca gaa cag aag ttc cag aaa gtg aag gga ttt gga ggg gcc atg aca        565
Pro Glu Gln Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr           
110                 115                 120                 125           

gat gct gct gct ctc aac atc ctt gcc ctg tca ccc cct gcc caa aat        613
Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn           
                130                 135                 140               

ttg cta ctt aaa tcg tac ttc tct gaa gaa gga atc gga tat aac atc        661
Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile           
            145                 150                 155                   

atc cgg gta ccc atg gcc agc tgt gac ttc tcc atc cgc acc tac acc        709
Ile Arg Val Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr           
        160                 165                 170                       

tat gca gac acc cct gat gat ttc cag ttg cac aac ttc agc ctc cca        757
Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro           
    175                 180                 185                           

gag gaa gat acc aag ctc aag ata ccc ctg att cac cga gcc ctg cag        805
Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln           
190                 195                 200                 205           

ttg gcc cag cgt ccc gtt tca ctc ctt gcc agc ccc tgg aca tca ccc        853
Leu Ala Gln Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro           
                210                 215                 220               

act tgg ctc aag acc aat gga gcg gtg aat ggg aag ggg tca ctc aag        901
Thr Trp Leu Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys           
            225                 230                 235                   

gga cag ccc gga gac atc tac cac cag acc tgg gcc aga tac ttt gtg        949
Gly Gln Pro Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val           
        240                 245                 250                       

aag ttc ctg gat gcc tat gct gag cac aag tta cag ttc tgg gca gtg        997
Lys Phe Leu Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val           
    255                 260                 265                           

aca gct gaa aat gag cct tct gct ggg ctg ttg agt gga tac ccc ttc       1045
Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe           
270                 275                 280                 285           

cag tgc ctg ggc ttc acc cct gaa cat cag cga gac ttc att gcc cgt       1093
Gln Cys Leu Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg           
                290                 295                 300               

gac cta ggt cct acc ctc gcc aac agt act cac cac aat gtc cgc cta       1141
Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu           
            305                 310                 315                   

ctc atg ctg gat gac caa cgc ttg ctg ctg ccc cac tgg gca aag gtg       1189
Leu Met Leu Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val           
        320                 325                 330                       

gta ctg aca gac cca gaa gca gct aaa tat gtt cat ggc att gct gta       1237
Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val           
    335                 340                 345                           

cat tgg tac ctg gac ttt ctg gct cca gcc aaa gcc acc cta ggg gag       1285
His Trp Tyr Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu           
350                 355                 360                 365           

aca cac cgc ctg ttc ccc aac acc atg ctc ttt gcc tca gag gcc tgt       1333
Thr His Arg Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys           
                370                 375                 380               

gtg ggc tcc aag ttc tgg gag cag agt gtg cgg cta ggc tcc tgg gat       1381
Val Gly Ser Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp           
            385                 390                 395                   

cga ggg atg cag tac agc cac agc atc atc acg aac ctc ctg tac cat       1429
Arg Gly Met Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His           
        400                 405                 410                       

gtg gtc ggc tgg acc gac tgg aac ctt gcc ctg aac ccc gaa gga gga       1477
Val Val Gly Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly           
    415                 420                 425                           

ccc aat tgg gtg cgt aac ttt gtc gac agt ccc atc att gta gac atc       1525
Pro Asn Trp Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile           
430                 435                 440                 445           

acc aag gac acg ttt tac aaa cag ccc atg ttc tac cac ctt ggc cac       1573
Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His           
                450                 455                 460               

ttc agc aag ttc att cct gag ggc tcc cag aga gtg ggg ctg gtt gcc       1621
Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala           
            465                 470                 475                   

agt cag aag aac gac ctg gac gca gtg gca ctg atg cat ccc gat ggc       1669
Ser Gln Lys Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly           
        480                 485                 490                       

tct gct gtt gtg gtc gtg cta aac cgc tcc tct aag gat gtg cct ctt       1717
Ser Ala Val Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu           
    495                 500                 505                           

acc atc aag gat cct gct gtg ggc ttc ctg gag aca atc tca cct ggc       1765
Thr Ile Lys Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly           
510                 515                 520                 525           

tac tcc att cac acc tac ctg tgg cgt cgc cag tga tggagcagat            1811
Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg Gln                               
                530                 535                                   

actcaaggag gcactgggct cagcctgggc attaaaggga cagagtcagc tcacacgctg     1871

tctgtgacta aagagggcac agcagggcca gtgtgagctt acagcgacgt aagcccaggg     1931

gcaatggttt gggtgactca ctttcccctc taggtggtgc caggggctgg aggcccctag     1991

aaaaagatca gtaagcccca gtgtcccccc agcccccatg cttatgtgaa catgcgctgt     2051

gtgctgcttg ctttggaaac tgggcctggg tccaggccta gggtgagctc actgtccgta     2111

caaacacaag atcagggctg agggtaagga aaagaagaga ctaggaaagc tgggcccaaa     2171

actggagact gtttgtcttt cctggagatg cagaactggg cccgtggagc agcagtgtca     2231

gcatcagggc ggaagcctta aagcagcagc gggtgtgccc aggcacccag atgattccta     2291

tggcaccagc caggaaaaat ggcagctctt aaaggagaaa atgtttgagc cca            2344


<210>  4
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  5
<211>  2325
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (172)..(1782)

<400>  5
atcctgcctt cagagtctta ctgcgcgggg ccccagtctc cagtcccgcc caggcgcctt       60

tgcaggctgc ggtgggattt cgttttgcct ccggttgggg ctgctgtttc tcttcgccga      120

cgagactctg gaacccctgt ggtcttctct tcatctaatg accctgaggg g atg gag       177
                                                         Met Glu          
                                                         1                

ttt tca agt cct tcc aga gag gaa tgt ccc aag cct ttg agt agg gta        225
Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser Arg Val           
        5                   10                  15                        

agc atc atg gct ggc agc ctc aca gga ttg ctt cta ctt cag gca gtg        273
Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln Ala Val           
    20                  25                  30                            

tcg tgg gca tca ggt gcc cgc ccc tgc atc cct aaa agc ttc ggc tac        321
Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr           
35                  40                  45                  50            

agc tcg gtg gtg tgt gtc tgc aat gcc aca tac tgt gac tcc ttt gac        369
Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp           
                55                  60                  65                

ccc ccg acc ttt cct gcc ctt ggt acc ttc agc cgc tat gag agt aca        417
Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr           
            70                  75                  80                    

cgc agt ggg cga cgg atg gag ctg agt atg ggg ccc atc cag gct aat        465
Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn           
        85                  90                  95                        

cac acg ggc aca ggc ctg cta ctg acc ctg cag cca gaa cag aag ttc        513
His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe           
    100                 105                 110                           

cag aaa gtg aag gga ttt gga ggg gcc atg aca gat gct gct gct ctc        561
Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu           
115                 120                 125                 130           

aac atc ctt gcc ctg tca ccc cct gcc caa aat ttg cta ctt aaa tcg        609
Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser           
                135                 140                 145               

tac ttc tct gaa gaa gga atc gga tat aac atc atc cgg gta ccc atg        657
Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met           
            150                 155                 160                   

gcc agc tgt gac ttc tcc atc cgc acc tac acc tat gca gac acc cct        705
Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro           
        165                 170                 175                       

gat gat ttc cag ttg cac aac ttc agc ctc cca gag gaa gat acc aag        753
Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys           
    180                 185                 190                           

ctc aag ata ccc ctg att cac cga gcc ctg cag ttg gcc cag cgt ccc        801
Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro           
195                 200                 205                 210           

gtt tca ctc ctt gcc agc ccc tgg aca tca ccc act tgg ctc aag acc        849
Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr           
                215                 220                 225               

aat gga gcg gtg aat ggg aag ggg tca ctc aag gga cag ccc gga gac        897
Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp           
            230                 235                 240                   

atc tac cac cag acc tgg gcc aga tac ttt gtg aag ttc ctg gat gcc        945
Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala           
        245                 250                 255                       

tat gct gag cac aag tta cag ttc tgg gca gtg aca gct gaa aat gag        993
Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu           
    260                 265                 270                           

cct tct gct ggg ctg ttg agt gga tac ccc ttc cag tgc ctg ggc ttc       1041
Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe           
275                 280                 285                 290           

acc cct gaa cat cag cga gac ttc att gcc cgt gac cta ggt cct acc       1089
Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr           
                295                 300                 305               

ctc gcc aac agt act cac cac aat gtc cgc cta ctc atg ctg gat gac       1137
Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu Asp Asp           
            310                 315                 320                   

caa cgc ttg ctg ctg ccc cac tgg gca aag gtg gta ctg aca gac cca       1185
Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr Asp Pro           
        325                 330                 335                       

gaa gca gct aaa tat gtt cat ggc att gct gta cat tgg tac ctg gac       1233
Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr Leu Asp           
    340                 345                 350                           

ttt ctg gct cca gcc aaa gcc acc cta ggg gag aca cac cgc ctg ttc       1281
Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe           
355                 360                 365                 370           

ccc aac acc atg ctc ttt gcc tca gag gcc tgt gtg ggc tcc aag ttc       1329
Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe           
                375                 380                 385               

tgg gag cag agt gtg cgg cta ggc tcc tgg gat cga ggg atg cag tac       1377
Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr           
            390                 395                 400                   

agc cac agc atc atc acg aac ctc ctg tac cat gtg gtc ggc tgg acc       1425
Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr           
        405                 410                 415                       

gac tgg aac ctt gcc ctg aac ccc gaa gga gga ccc aat tgg gtg cgt       1473
Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg           
    420                 425                 430                           

aac ttt gtc gac agt ccc atc att gta gac atc acc aag gac acg ttt       1521
Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe           
435                 440                 445                 450           

tac aaa cag ccc atg ttc tac cac ctt ggc cac ttc agc aag ttc att       1569
Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile           
                455                 460                 465               

cct gag ggc tcc cag aga gtg ggg ctg gtt gcc agt cag aag aac gac       1617
Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp           
            470                 475                 480                   

ctg gac gca gtg gca ctg atg cat ccc gat ggc tct gct gtt gtg gtc       1665
Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val Val Val           
        485                 490                 495                       

gtg cta aac cgc tcc tct aag gat gtg cct ctt acc atc aag gat cct       1713
Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro           
    500                 505                 510                           

gct gtg ggc ttc ctg gag aca atc tca cct ggc tac tcc att cac acc       1761
Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr           
515                 520                 525                 530           

tac ctg tgg cgt cgc cag tga tggagcagat actcaaggag gcactgggct          1812
Tyr Leu Trp Arg Arg Gln                                                   
                535                                                       

cagcctgggc attaaaggga cagagtcagc tcacacgctg tctgtgacta aagagggcac     1872

agcagggcca gtgtgagctt acagcgacgt aagcccaggg gcaatggttt gggtgactca     1932

ctttcccctc taggtggtgc caggggctgg aggcccctag aaaaagatca gtaagcccca     1992

gtgtcccccc agcccccatg cttatgtgaa catgcgctgt gtgctgcttg ctttggaaac     2052

tgggcctggg tccaggccta gggtgagctc actgtccgta caaacacaag atcagggctg     2112

agggtaagga aaagaagaga ctaggaaagc tgggcccaaa actggagact gtttgtcttt     2172

cctggagatg cagaactggg cccgtggagc agcagtgtca gcatcagggc ggaagcctta     2232

aagcagcagc gggtgtgccc aggcacccag atgattccta tggcaccagc caggaaaaat     2292

ggcagctctt aaaggagaaa atgtttgagc cca                                  2325


<210>  6
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  7
<211>  2161
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (269)..(1618)

<400>  7
atcctgcctt cagagtctta ctgcgcgggg ccccagtctc cagtcccgcc caggcgcctt       60

tgcaggctgc ggtgggattt cgttttgcct ccggttgggg ctgctgtttc tcttcgccga      120

cggtgcccgc ccctgcatcc ctaaaagctt cggctacagc tcggtggtgt gtgtctgcaa      180

tgccacatac tgtgactcct ttgacccccc gacctttcct gcccttggta ccttcagccg      240

ctatgagagt acacgcagtg ggcgacgg atg gag ctg agt atg ggg ccc atc         292
                               Met Glu Leu Ser Met Gly Pro Ile            
                               1               5                          

cag gct aat cac acg ggc aca ggc ctg cta ctg acc ctg cag cca gaa        340
Gln Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu           
    10                  15                  20                            

cag aag ttc cag aaa gtg aag gga ttt gga ggg gcc atg aca gat gct        388
Gln Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala           
25                  30                  35                  40            

gct gct ctc aac atc ctt gcc ctg tca ccc cct gcc caa aat ttg cta        436
Ala Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu           
                45                  50                  55                

ctt aaa tcg tac ttc tct gaa gaa gga atc gga tat aac atc atc cgg        484
Leu Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg           
            60                  65                  70                    

gta ccc atg gcc agc tgt gac ttc tcc atc cgc acc tac acc tat gca        532
Val Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala           
        75                  80                  85                        

gac acc cct gat gat ttc cag ttg cac aac ttc agc ctc cca gag gaa        580
Asp Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu           
    90                  95                  100                           

gat acc aag ctc aag ata ccc ctg att cac cga gcc ctg cag ttg gcc        628
Asp Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala           
105                 110                 115                 120           

cag cgt ccc gtt tca ctc ctt gcc agc ccc tgg aca tca ccc act tgg        676
Gln Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp           
                125                 130                 135               

ctc aag acc aat gga gcg gtg aat ggg aag ggg tca ctc aag gga cag        724
Leu Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln           
            140                 145                 150                   

ccc gga gac atc tac cac cag acc tgg gcc aga tac ttt gtg aag ttc        772
Pro Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe           
        155                 160                 165                       

ctg gat gcc tat gct gag cac aag tta cag ttc tgg gca gtg aca gct        820
Leu Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala           
    170                 175                 180                           

gaa aat gag cct tct gct ggg ctg ttg agt gga tac ccc ttc cag tgc        868
Glu Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys           
185                 190                 195                 200           

ctg ggc ttc acc cct gaa cat cag cga gac ttc att gcc cgt gac cta        916
Leu Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu           
                205                 210                 215               

ggt cct acc ctc gcc aac agt act cac cac aat gtc cgc cta ctc atg        964
Gly Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met           
            220                 225                 230                   

ctg gat gac caa cgc ttg ctg ctg ccc cac tgg gca aag gtg gta ctg       1012
Leu Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu           
        235                 240                 245                       

aca gac cca gaa gca gct aaa tat gtt cat ggc att gct gta cat tgg       1060
Thr Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp           
    250                 255                 260                           

tac ctg gac ttt ctg gct cca gcc aaa gcc acc cta ggg gag aca cac       1108
Tyr Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His           
265                 270                 275                 280           

cgc ctg ttc ccc aac acc atg ctc ttt gcc tca gag gcc tgt gtg ggc       1156
Arg Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly           
                285                 290                 295               

tcc aag ttc tgg gag cag agt gtg cgg cta ggc tcc tgg gat cga ggg       1204
Ser Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly           
            300                 305                 310                   

atg cag tac agc cac agc atc atc acg aac ctc ctg tac cat gtg gtc       1252
Met Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val           
        315                 320                 325                       

ggc tgg acc gac tgg aac ctt gcc ctg aac ccc gaa gga gga ccc aat       1300
Gly Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn           
    330                 335                 340                           

tgg gtg cgt aac ttt gtc gac agt ccc atc att gta gac atc acc aag       1348
Trp Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys           
345                 350                 355                 360           

gac acg ttt tac aaa cag ccc atg ttc tac cac ctt ggc cac ttc agc       1396
Asp Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser           
                365                 370                 375               

aag ttc att cct gag ggc tcc cag aga gtg ggg ctg gtt gcc agt cag       1444
Lys Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln           
            380                 385                 390                   

aag aac gac ctg gac gca gtg gca ctg atg cat ccc gat ggc tct gct       1492
Lys Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala           
        395                 400                 405                       

gtt gtg gtc gtg cta aac cgc tcc tct aag gat gtg cct ctt acc atc       1540
Val Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile           
    410                 415                 420                           

aag gat cct gct gtg ggc ttc ctg gag aca atc tca cct ggc tac tcc       1588
Lys Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser           
425                 430                 435                 440           

att cac acc tac ctg tgg cgt cgc cag tga tggagcagat actcaaggag         1638
Ile His Thr Tyr Leu Trp Arg Arg Gln                                       
                445                                                       

gcactgggct cagcctgggc attaaaggga cagagtcagc tcacacgctg tctgtgacta     1698

aagagggcac agcagggcca gtgtgagctt acagcgacgt aagcccaggg gcaatggttt     1758

gggtgactca ctttcccctc taggtggtgc caggggctgg aggcccctag aaaaagatca     1818

gtaagcccca gtgtcccccc agcccccatg cttatgtgaa catgcgctgt gtgctgcttg     1878

ctttggaaac tgggcctggg tccaggccta gggtgagctc actgtccgta caaacacaag     1938

atcagggctg agggtaagga aaagaagaga ctaggaaagc tgggcccaaa actggagact     1998

gtttgtcttt cctggagatg cagaactggg cccgtggagc agcagtgtca gcatcagggc     2058

ggaagcctta aagcagcagc gggtgtgccc aggcacccag atgattccta tggcaccagc     2118

caggaaaaat ggcagctctt aaaggagaaa atgtttgagc cca                       2161


<210>  8
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
1               5                   10                  15      


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
            20                  25                  30          


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
        35                  40                  45              


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
    50                  55                  60                  


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
65                  70                  75                  80  


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
                85                  90                  95      


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
            100                 105                 110         


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
        115                 120                 125             


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
    130                 135                 140                 


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
145                 150                 155                 160 


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
                165                 170                 175     


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
            180                 185                 190         


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
        195                 200                 205             


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
    210                 215                 220                 


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
225                 230                 235                 240 


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
                245                 250                 255     


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
            260                 265                 270         


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
        275                 280                 285             


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
    290                 295                 300                 


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
305                 310                 315                 320 


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
                325                 330                 335     


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
            340                 345                 350         


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
        355                 360                 365             


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
    370                 375                 380                 


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
385                 390                 395                 400 


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
                405                 410                 415     


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
            420                 425                 430         


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
        435                 440                 445             


Gln 
    


<210>  9
<211>  2144
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (138)..(1601)

<400>  9
ggaattactt gcagggctaa cctagtgcct atagctaagg caggtacctg catccttgtt       60

tttgtttagt ggatcctcta tccttcagag actctggaac ccctgtggtc ttctcttcat      120

ctaatgaccc tgagggg atg gag ttt tca agt cct tcc aga gag gaa tgt         170
                   Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys            
                   1               5                   10                 

ccc aag cct ttg agt agg gta agc atc atg gct ggc agc ctc aca gga        218
Pro Lys Pro Leu Ser Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly           
            15                  20                  25                    

ttg ctt cta ctt cag gca gtg tcg tgg gca tca ggt gcc cgc ccc tgc        266
Leu Leu Leu Leu Gln Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys           
        30                  35                  40                        

atc cct aaa agc ttc ggc tac agc tcg gtg gtg tgt gtc tgc aat gcc        314
Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala           
    45                  50                  55                            

aca tac tgt gac tcc ttt gac ccc ccg acc ttt cct gcc ctt ggt acc        362
Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr           
60                  65                  70                  75            

ttc agc cgc tat gag agt aca cgc agt ggg cga cgg atg gag ctg agt        410
Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser           
                80                  85                  90                

atg ggg ccc atc cag gct aat cac acg ggc aca gga atc gga tat aac        458
Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly Ile Gly Tyr Asn           
            95                  100                 105                   

atc atc cgg gta ccc atg gcc agc tgt gac ttc tcc atc cgc acc tac        506
Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr           
        110                 115                 120                       

acc tat gca gac acc cct gat gat ttc cag ttg cac aac ttc agc ctc        554
Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu           
    125                 130                 135                           

cca gag gaa gat acc aag ctc aag ata ccc ctg att cac cga gcc ctg        602
Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu           
140                 145                 150                 155           

cag ttg gcc cag cgt ccc gtt tca ctc ctt gcc agc ccc tgg aca tca        650
Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser           
                160                 165                 170               

ccc act tgg ctc aag acc aat gga gcg gtg aat ggg aag ggg tca ctc        698
Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu           
            175                 180                 185                   

aag gga cag ccc gga gac atc tac cac cag acc tgg gcc aga tac ttt        746
Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe           
        190                 195                 200                       

gtg aag ttc ctg gat gcc tat gct gag cac aag tta cag ttc tgg gca        794
Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala           
    205                 210                 215                           

gtg aca gct gaa aat gag cct tct gct ggg ctg ttg agt gga tac ccc        842
Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro           
220                 225                 230                 235           

ttc cag tgc ctg ggc ttc acc cct gaa cat cag cga gac ttc att gcc        890
Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala           
                240                 245                 250               

cgt gac cta ggt cct acc ctc gcc aac agt act cac cac aat gtc cgc        938
Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg           
            255                 260                 265                   

cta ctc atg ctg gat gac caa cgc ttg ctg ctg ccc cac tgg gca aag        986
Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys           
        270                 275                 280                       

gtg gta ctg aca gac cca gaa gca gct aaa tat gtt cat ggc att gct       1034
Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala           
    285                 290                 295                           

gta cat tgg tac ctg gac ttt ctg gct cca gcc aaa gcc acc cta ggg       1082
Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly           
300                 305                 310                 315           

gag aca cac cgc ctg ttc ccc aac acc atg ctc ttt gcc tca gag gcc       1130
Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala           
                320                 325                 330               

tgt gtg ggc tcc aag ttc tgg gag cag agt gtg cgg cta ggc tcc tgg       1178
Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp           
            335                 340                 345                   

gat cga ggg atg cag tac agc cac agc atc atc acg aac ctc ctg tac       1226
Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr           
        350                 355                 360                       

cat gtg gtc ggc tgg acc gac tgg aac ctt gcc ctg aac ccc gaa gga       1274
His Val Val Gly Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly           
    365                 370                 375                           

gga ccc aat tgg gtg cgt aac ttt gtc gac agt ccc atc att gta gac       1322
Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp           
380                 385                 390                 395           

atc acc aag gac acg ttt tac aaa cag ccc atg ttc tac cac ctt ggc       1370
Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly           
                400                 405                 410               

cac ttc agc aag ttc att cct gag ggc tcc cag aga gtg ggg ctg gtt       1418
His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val           
            415                 420                 425                   

gcc agt cag aag aac gac ctg gac gca gtg gca ctg atg cat ccc gat       1466
Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp           
        430                 435                 440                       

ggc tct gct gtt gtg gtc gtg cta aac cgc tcc tct aag gat gtg cct       1514
Gly Ser Ala Val Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro           
    445                 450                 455                           

ctt acc atc aag gat cct gct gtg ggc ttc ctg gag aca atc tca cct       1562
Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro           
460                 465                 470                 475           

ggc tac tcc att cac acc tac ctg tgg cgt cgc cag tga tggagcagat        1611
Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg Gln                           
                480                 485                                   

actcaaggag gcactgggct cagcctgggc attaaaggga cagagtcagc tcacacgctg     1671

tctgtgacta aagagggcac agcagggcca gtgtgagctt acagcgacgt aagcccaggg     1731

gcaatggttt gggtgactca ctttcccctc taggtggtgc caggggctgg aggcccctag     1791

aaaaagatca gtaagcccca gtgtcccccc agcccccatg cttatgtgaa catgcgctgt     1851

gtgctgcttg ctttggaaac tgggcctggg tccaggccta gggtgagctc actgtccgta     1911

caaacacaag atcagggctg agggtaagga aaagaagaga ctaggaaagc tgggcccaaa     1971

actggagact gtttgtcttt cctggagatg cagaactggg cccgtggagc agcagtgtca     2031

gcatcagggc ggaagcctta aagcagcagc gggtgtgccc aggcacccag atgattccta     2091

tggcaccagc caggaaaaat ggcagctctt aaaggagaaa atgtttgagc cca            2144


<210>  10
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro 
            100                 105                 110         


Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr 
        115                 120                 125             


Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp Thr 
    130                 135                 140                 


Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln Arg 
145                 150                 155                 160 


Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys 
                165                 170                 175     


Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly 
            180                 185                 190         


Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp 
        195                 200                 205             


Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu Asn 
    210                 215                 220                 


Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly 
225                 230                 235                 240 


Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro 
                245                 250                 255     


Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu Asp 
            260                 265                 270         


Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr Asp 
        275                 280                 285             


Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr Leu 
    290                 295                 300                 


Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg Leu 
305                 310                 315                 320 


Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser Lys 
                325                 330                 335     


Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met Gln 
            340                 345                 350         


Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly Trp 
        355                 360                 365             


Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp Val 
    370                 375                 380                 


Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp Thr 
385                 390                 395                 400 


Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys Phe 
                405                 410                 415     


Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys Asn 
            420                 425                 430         


Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val Val 
        435                 440                 445             


Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys Asp 
    450                 455                 460                 


Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile His 
465                 470                 475                 480 


Thr Tyr Leu Trp Arg Arg Gln 
                485         


<210>  11
<211>  3959
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (403)..(1587)

<400>  11
agtgcgcgga gctgcggcgg tggagctgct cggccgggag cccggcggcg agacggagag       60

gcggcggagg tgcccgcgcg cagggtctgg tgggcggccg cgaggctcgg gagaggcgaa      120

ccggagcgcg ggaccgcggt cgccccgacc agagccggga gaccgcagca cccgcagccg      180

cccgcgagcg cgccgaagac agcgcgcagg cgagagcgcg cgggcggggg cgcgcaggcc      240

ctgcccgccc cttccgtccc cacccccctc cgccctttcc tctccccacc ttcctctcgc      300

ctcccgcgcc cccgcaccgg gcgcccaccc tgtcctcctc ctgcgggagc gttgtccgtg      360

ttggcggccg cagcgggccg ggccggtccg gcgggccggg gg atg gcg ctg ctg         414
                                               Met Ala Leu Leu            
                                               1                          

gac ctg gcc ttg gag gga atg gcc gtc ttc ggg ttc gtc ctc ttc ttg        462
Asp Leu Ala Leu Glu Gly Met Ala Val Phe Gly Phe Val Leu Phe Leu           
5                   10                  15                  20            

gtg ctg tgg ctg atg cat ttc atg gct atc atc tac acc cga tta cac        510
Val Leu Trp Leu Met His Phe Met Ala Ile Ile Tyr Thr Arg Leu His           
                25                  30                  35                

ctc aac aag aag gca act gac aaa cag cct tat agc aag ctc cca ggt        558
Leu Asn Lys Lys Ala Thr Asp Lys Gln Pro Tyr Ser Lys Leu Pro Gly           
            40                  45                  50                    

gtc tct ctt ctg aaa cca ctg aaa ggg gta gat cct aac tta atc aac        606
Val Ser Leu Leu Lys Pro Leu Lys Gly Val Asp Pro Asn Leu Ile Asn           
        55                  60                  65                        

aac ctg gaa aca ttc ttt gaa ttg gat tat ccc aaa tat gaa gtg ctc        654
Asn Leu Glu Thr Phe Phe Glu Leu Asp Tyr Pro Lys Tyr Glu Val Leu           
    70                  75                  80                            

ctt tgt gta caa gat cat gat gat cca gcc att gat gta tgt aag aag        702
Leu Cys Val Gln Asp His Asp Asp Pro Ala Ile Asp Val Cys Lys Lys           
85                  90                  95                  100           

ctt ctt gga aaa tat cca aat gtt gat gct aga ttg ttt ata ggt ggc        750
Leu Leu Gly Lys Tyr Pro Asn Val Asp Ala Arg Leu Phe Ile Gly Gly           
                105                 110                 115               

aaa aaa gtt ggc att aat cct aaa att aat aat tta atg cca gga tat        798
Lys Lys Val Gly Ile Asn Pro Lys Ile Asn Asn Leu Met Pro Gly Tyr           
            120                 125                 130                   

gaa gtt gca aag tat gat ctt ata tgg att tgt gat agt gga ata aga        846
Glu Val Ala Lys Tyr Asp Leu Ile Trp Ile Cys Asp Ser Gly Ile Arg           
        135                 140                 145                       

gta att cca gat acg ctt act gac atg gtg aat caa atg aca gaa aaa        894
Val Ile Pro Asp Thr Leu Thr Asp Met Val Asn Gln Met Thr Glu Lys           
    150                 155                 160                           

gta ggc ttg gtt cac ggg ctg cct tac gta gca gac aga cag ggc ttt        942
Val Gly Leu Val His Gly Leu Pro Tyr Val Ala Asp Arg Gln Gly Phe           
165                 170                 175                 180           

gct gcc acc tta gag cag gta tat ttt gga act tca cat cca aga tac        990
Ala Ala Thr Leu Glu Gln Val Tyr Phe Gly Thr Ser His Pro Arg Tyr           
                185                 190                 195               

tat atc tct gcc aat gta act ggt ttc aaa tgt gtg aca gga atg tct       1038
Tyr Ile Ser Ala Asn Val Thr Gly Phe Lys Cys Val Thr Gly Met Ser           
            200                 205                 210                   

tgt tta atg aga aaa gat gtg ttg gat caa gca gga gga ctt ata gct       1086
Cys Leu Met Arg Lys Asp Val Leu Asp Gln Ala Gly Gly Leu Ile Ala           
        215                 220                 225                       

ttt gct cag tac att gcc gaa gat tac ttt atg gcc aaa gcg ata gct       1134
Phe Ala Gln Tyr Ile Ala Glu Asp Tyr Phe Met Ala Lys Ala Ile Ala           
    230                 235                 240                           

gac cga ggt tgg agg ttt gca atg tcc act caa gtt gca atg caa aac       1182
Asp Arg Gly Trp Arg Phe Ala Met Ser Thr Gln Val Ala Met Gln Asn           
245                 250                 255                 260           

tct ggc tca tat tca att tct cag ttt caa tcc aga atg atc agg tgg       1230
Ser Gly Ser Tyr Ser Ile Ser Gln Phe Gln Ser Arg Met Ile Arg Trp           
                265                 270                 275               

acc aaa cta cga att aac atg ctt cct gct aca ata att tgt gag cca       1278
Thr Lys Leu Arg Ile Asn Met Leu Pro Ala Thr Ile Ile Cys Glu Pro           
            280                 285                 290                   

att tca gaa tgc ttt gtt gcc agt tta att att gga tgg gca gcc cac       1326
Ile Ser Glu Cys Phe Val Ala Ser Leu Ile Ile Gly Trp Ala Ala His           
        295                 300                 305                       

cat gtg ttc aga tgg gat att atg gta ttt ttc atg tgt cat tgc ctg       1374
His Val Phe Arg Trp Asp Ile Met Val Phe Phe Met Cys His Cys Leu           
    310                 315                 320                           

gca tgg ttt ata ttt gac tac att caa ctc agg ggt gtc cag ggt ggc       1422
Ala Trp Phe Ile Phe Asp Tyr Ile Gln Leu Arg Gly Val Gln Gly Gly           
325                 330                 335                 340           

aca ctg tgt ttt tca aaa ctt gat tat gca gtc gcc tgg ttc atc cgc       1470
Thr Leu Cys Phe Ser Lys Leu Asp Tyr Ala Val Ala Trp Phe Ile Arg           
                345                 350                 355               

gaa tcc atg aca ata tac att ttt ttg tct gca tta tgg gac cca act       1518
Glu Ser Met Thr Ile Tyr Ile Phe Leu Ser Ala Leu Trp Asp Pro Thr           
            360                 365                 370                   

ata agc tgg aga act ggt cgc tac aga tta cgc tgt ggg ggt aca gca       1566
Ile Ser Trp Arg Thr Gly Arg Tyr Arg Leu Arg Cys Gly Gly Thr Ala           
        375                 380                 385                       

gag gaa atc cta gat gta taa ctacagcttt gtgactgtat ataaaggaaa          1617
Glu Glu Ile Leu Asp Val                                                   
    390                                                                   

aaagagaagt attataaatt atgtttatat aaatgctttt aaaaatctac cttctgtagt     1677

tttatcacat gtatgttttg gtatctgttc tttaatttat ttttgcatgg cacttgcatc     1737

tgtgaaaaaa aaaaaaaaca catctgtagt cttggccaaa tgatacactt tattttgtgg     1797

aagtagagaa tcaagagaat tggttctagg aacctgggtt cgttcatcat tgttgtttat     1857

ttttttaaaa taaataaata aatatatata tagatgctct gcaacaaact ctgtgacagt     1917

atccttcagt agagaaagtt tcttacttgt gagtacactc ttttagaaca tttacgggtg     1977

gcagcagctt tgctttagag tttagaagat aatagaagga atgactattc atgtccaaag     2037

tgaatggttt tgtgcagtga acaacacatg gcgaggtact aactgagaaa ctttttcatg     2097

ctttatgcct acctcttgta gttgttgcag agcaaatata aattgtaata agatagctag     2157

gccttgcaga aacaaacaga aaaacttaaa aaaaaatgat ataagagctg gagtctagta     2217

tttatatgaa tctgtgagag ataatttttt tggtctcact gcaatgaacc aaaagcggct     2277

gagtttggtt tttaattgta gccatgtatt gaaggcatct ttttgaccaa ctcttgttgg     2337

ttctgtcttg aaccattgtt aatcactgtg ctgtaattag tatagctaaa tcttttcctt     2397

ccttgctcct cccccagccc accccgtctt cccttaacat tttttcaggg ggggttggga     2457

gtggtttcat tttagtgtga gtggatgttt tgatagttgt aaggaaaaaa tgcatttcag     2517

acacatttca cacatgagct attttcttac acagtatgtc ttattgttaa taagaatgta     2577

atttcatgat acaagtattt aatacctttt ttaagtcagt aaatattcta gccatcaata     2637

aattgcagta gagtattaag aggggacagg atgagtttac tcttaaaatt aatcagtatc     2697

aaactaagtc tactgtgtgt gttttttttt tttgtttttt gtttttgttt gtttactatt     2757

atagtaagtc tagtcttatt taaattggat ttttgtattc aagtttatat gacaaaatag     2817

actagatcag cgctggttgt aaatgcatgc tgtacctcac tgttttctcc ccatcatgcc     2877

gctaaacttg ctcgccaggt tgtgcttaac ttgtggtgaa ctggacttga ttctgttttg     2937

ttttgttttt ttaaaaaaaa aaaacaaaaa tgtaagggac agtgcataag ccttttcttt     2997

gttaagtagt ggtgttttgc tttttcttca ggattggatg gcatgttgtc cacaggaatg     3057

cctactgcag ggctaacact ggcaatatgg cagctttaaa ttctgagtta ctacagtctc     3117

catgtcaaag cataatgtgt agcatatcag caataactac atatttatag aaaacacttt     3177

ttcactttac tgagccaatt catttaattg tcaaatgtct atatccatgg tttaaatggc     3237

aacatatcta taagtatgta tacacattat atttaagctt ttctctgggc caaactgctt     3297

catccttttt tctttctttt tttttttttt tagccttatg atgaatttgt ttgaagggca     3357

ttttctttat gaacaaaggc ttggatgcat attcctttct ttctgtgaat gggtattatt     3417

ccctgaggaa agttgcacag tgaaaaccag tctggttgtg acccactaca tgttttgttt     3477

ttaatcacta ttacctgagt tgaactttgc tcaccatgtt tgtacttgtt ggtctgttta     3537

atgaagtttg gttgatgcca tcctttgcac tgccgaagcg taatcttgtg tattacttag     3597

ctctctgctg atctcagtat ggacagtgta acaacaaaac caaaatggct ggacagactt     3657

cttgtgtttt gtaaatataa actaggacag ttctgtaggt ttgttcagtg tgctagtgga     3717

gtatttcctt aatgtaaaac ttcacttaac agagagattc tttgtttagc aagcttggag     3777

tgatgataaa atggtaagaa ataatataaa tgttgaagaa agcatcacaa cagaactata     3837

ggagtctaaa tttaataaat ctttaaaaaa aaccagtgtc tagaatatat accatgtttt     3897

attatttaaa atcattgtct taaatttttg ttcaaaaaat aaaaatttga atacaatcaa     3957

aa                                                                    3959


<210>  12
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Leu Leu Asp Leu Ala Leu Glu Gly Met Ala Val Phe Gly Phe 
1               5                   10                  15      


Val Leu Phe Leu Val Leu Trp Leu Met His Phe Met Ala Ile Ile Tyr 
            20                  25                  30          


Thr Arg Leu His Leu Asn Lys Lys Ala Thr Asp Lys Gln Pro Tyr Ser 
        35                  40                  45              


Lys Leu Pro Gly Val Ser Leu Leu Lys Pro Leu Lys Gly Val Asp Pro 
    50                  55                  60                  


Asn Leu Ile Asn Asn Leu Glu Thr Phe Phe Glu Leu Asp Tyr Pro Lys 
65                  70                  75                  80  


Tyr Glu Val Leu Leu Cys Val Gln Asp His Asp Asp Pro Ala Ile Asp 
                85                  90                  95      


Val Cys Lys Lys Leu Leu Gly Lys Tyr Pro Asn Val Asp Ala Arg Leu 
            100                 105                 110         


Phe Ile Gly Gly Lys Lys Val Gly Ile Asn Pro Lys Ile Asn Asn Leu 
        115                 120                 125             


Met Pro Gly Tyr Glu Val Ala Lys Tyr Asp Leu Ile Trp Ile Cys Asp 
    130                 135                 140                 


Ser Gly Ile Arg Val Ile Pro Asp Thr Leu Thr Asp Met Val Asn Gln 
145                 150                 155                 160 


Met Thr Glu Lys Val Gly Leu Val His Gly Leu Pro Tyr Val Ala Asp 
                165                 170                 175     


Arg Gln Gly Phe Ala Ala Thr Leu Glu Gln Val Tyr Phe Gly Thr Ser 
            180                 185                 190         


His Pro Arg Tyr Tyr Ile Ser Ala Asn Val Thr Gly Phe Lys Cys Val 
        195                 200                 205             


Thr Gly Met Ser Cys Leu Met Arg Lys Asp Val Leu Asp Gln Ala Gly 
    210                 215                 220                 


Gly Leu Ile Ala Phe Ala Gln Tyr Ile Ala Glu Asp Tyr Phe Met Ala 
225                 230                 235                 240 


Lys Ala Ile Ala Asp Arg Gly Trp Arg Phe Ala Met Ser Thr Gln Val 
                245                 250                 255     


Ala Met Gln Asn Ser Gly Ser Tyr Ser Ile Ser Gln Phe Gln Ser Arg 
            260                 265                 270         


Met Ile Arg Trp Thr Lys Leu Arg Ile Asn Met Leu Pro Ala Thr Ile 
        275                 280                 285             


Ile Cys Glu Pro Ile Ser Glu Cys Phe Val Ala Ser Leu Ile Ile Gly 
    290                 295                 300                 


Trp Ala Ala His His Val Phe Arg Trp Asp Ile Met Val Phe Phe Met 
305                 310                 315                 320 


Cys His Cys Leu Ala Trp Phe Ile Phe Asp Tyr Ile Gln Leu Arg Gly 
                325                 330                 335     


Val Gln Gly Gly Thr Leu Cys Phe Ser Lys Leu Asp Tyr Ala Val Ala 
            340                 345                 350         


Trp Phe Ile Arg Glu Ser Met Thr Ile Tyr Ile Phe Leu Ser Ala Leu 
        355                 360                 365             


Trp Asp Pro Thr Ile Ser Trp Arg Thr Gly Arg Tyr Arg Leu Arg Cys 
    370                 375                 380                 


Gly Gly Thr Ala Glu Glu Ile Leu Asp Val 
385                 390                 


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artifically synthesized oligonucleotide

<400>  13
cttctaaccg aggtcgaaac g                                                 21


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artifically synthesized oligonucleotide

<400>  14
ggcattttgg acaaagcgtc ta                                                22


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artifically synthesized oligonucleotide

<400>  15
aagcttcggc tacagctcgg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artifically synthesized oligonucleotide

<400>  16
tcctaactta atcaacaacc                                                   20


<210>  17
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artifically truncated UGCG amino acid sequence

<400>  17

Met Ala Leu Leu Asp Leu Ala Leu Glu Gly Met Ala Val Phe Gly Phe 
1               5                   10                  15      


Val Leu Phe Leu Val Leu Trp Leu Met His Phe Met Ala Ile Ile Tyr 
            20                  25                  30          


Thr Arg Leu His Leu Asn Lys Lys Ala Thr Asp Lys Gln Pro Tyr Ser 
        35                  40                  45              


Lys Leu Pro Gly Val Ser Leu Leu Lys Pro Leu Lys Gly Val Asp Pro 
    50                  55                  60                  


Asn Leu Ile Lys Leu Asn Pro Asn Leu Thr Trp Lys His Ser Leu Asn 
65                  70                  75                  80  


Trp Ile Ile Pro Lys 
                85  


