                         SEQUENCE LISTING

<110>  DuPont Nutrition Biosciences ApS
 
<120>  NEW LACTIC ACID BACTERIA

<130>  NB41527-WO-PCT

<150>  EP19162856
<151>  2019-03-14

<150>  CN201910406044
<151>  2019-05-16

<150>  EP19214119
<151>  2019-12-06

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  3081
<212>  DNA
<213>  Streptococcus thermophilus

<400>  1
atgaacatga ctgaaaaaat tcaaacttat ttaaacgatc caaagattgt tagcgttaat       60

actgttgatg ctcactcaga tcataagtat tttgaatctc ttgaagaatt ttctgaaggg      120

gagatgaagt taagacaatc tcttaatgga aaatggaaaa ttcactatgc tcagaataca      180

aatcaggttt taaaagactt ttataaaaca gaatttgatg aaactgattt gaatttcatc      240

aatgtaccag gtcatttaga gcttcaaggt tttggttctc cacaatatgt gaatacccaa      300

tatccttggg atggtaaaga attccttcgt ccacctcaag ttcctcaaga atcaaatgct      360

gttgcatcat acgttaaaca ttttaccttg aatgatgcat taaaagataa aaaagtattt      420

atctcattcc aaggggttgc tacttccatc tttgtatggg tcaatggtaa cttcgtagga      480

tacagtgaag attcatttac acctagtgaa tttgaaatta gtgattacct tgttgaaggt      540

gataacaagt tggcggtagc tgtttatcgt tactctacag caagctggtt ggaagaccaa      600

gacttctgga gactttacgg tatttttaga gatgtttact tgtatgctat tccaaaagtt      660

cacgttcaag atctctttgt taagggagat tatgattacc aaacaaaagc aggtcaattg      720

gatattgatt tgaagactgt tggtgattat gaagacaaga agattaaata tgttctttca      780

gattatgaag gcatcgttac agaaggtgat gcatctgtta atggtgacgg tgaactatct      840

gtaagtcttg aaaatcttaa aatcaaacct tggagtgctg aaagtcctaa actttacgat      900

ttgatccttc atgttttgga tgatgaccaa gttgttgaag tcgttccagt taaagttgga      960

ttcagacgct ttgaaattaa agataaactt atgcttttga atggtaagag aattgtcttt     1020

aaaggggtta acagacacga atttaacgct agaacaggac gttgtatcac tgaagaagat     1080

atgctttggg atatcaaagt gatgaagcaa cataacatca atgctgttcg tacttcacac     1140

tatcctaacc aaacacgttg gtatgaattg tgtgatgaat atggacttta tgttatcgat     1200

gaagccaacc ttgaaacaca cggtacatgg caaaaacttg gtctatgcga accttcatgg     1260

aatatcccag ctagtgaacc agaatggttg cctgcttgtt tggatcgtgc caataacatg     1320

ttccaacgcg ataagaacca cgctagtgtt atcatttggt cttgtggtaa tgaatcatat     1380

gctggtaaag atattgctga catggctgat tacttccgta gtgttgacaa tactcgtcca     1440

gttcactatg aaggtgttgc atggtgtcgt gagtttgatt acattacaga catcgaaagt     1500

cgtatgtatg cgaaaccagc tgatatcgaa gaatacctca caactggtaa actagttgat     1560

ctttcaagcg ttagtgataa acactttgct tcaggtaacc taactaacaa acctcaaaaa     1620

ccttatattt catgtgaata catgcacaca atgggtaact ctggtggtgg attgcaactc     1680

tacactgact tagagaaata tccagaatac caaggtggat ttatttggga cttcattgac     1740

caagctattt acaaaacact tccaaatggt agcgaattcc tatcatatgg tggtgactgg     1800

catgatagac cttctgacta cgaattttgt ggaaatggta tcgtctttgc agatcgtacc     1860

ctaactccaa aacttcaaac agttaaacat ctttactcta atattaagat tgctgttgat     1920

gaaaaatcag taactatcaa gaatgataat ctcttcgaag atctttctgc ttatactttc     1980

ctagctagag tttacgaaga tggtagaaaa gttagtgaaa gtgaatatca ctttgatgtt     2040

aaaccaggcg aagaagcaac attcccagtt aactttgtag tcgaggcttc aaattctgaa     2100

caaatttacg aagttgcttg tgttctgagg gaagcaactg aatgggctcc taaaggtcat     2160

gaaattgttc gtggtcaata tgttgttgaa aagattagca ctgaaacacc agttaaagca     2220

cctttgaatg ttgttgaagg cgacttcaac atcggtattc aaggacaaaa cttctcaatc     2280

ttgctttcac gtgcacaaaa tactttagta tctgctaagt ataatggtgt tgaattcatt     2340

gagaaaggtc ctaaacttag cttcactcgt gcttacactg acaacgatcg tggtgctgga     2400

tatccattcg aaatggcagg ctggaaggtt gctggaaact atagtaaagt tacagatact     2460

caaattcaaa tcgaagacga ctctgttaaa gtgacttatg ttcatgaatt gccaggcttg     2520

tctgatgtcg aagttaaggt aacttatcaa gttgattaca agggtcgaat ctttgttact     2580

gcaaactatg atggtaaagc aggtttgcca aacttccctg aatttggtct agaatttgct     2640

atcggttcac aatttacaaa ccttagctat tatggatacg gtgcagaaga aagctaccgt     2700

gataaacttc ctggtgccta tcttggtcga tatgaaacat ctgttgaaaa gacatttgct     2760

ccatatctaa tgccacaaga atctggtaat cactatggta ctcgtgaatt cacagtatct     2820

gatgataacc ataatggtct taaattcacc gcacttaata aagcattcga attcagtgct     2880

ttgcgtaaca gtactgaaca aattgaaaat gctcgtcacc aatatgagtt gcaagaatct     2940

gatgctacat ggattaaagt tcttgctgct caaatgggtg taggtggtga cgacacatgg     3000

ggtgctccag ttcatgacga attcttgctt agctcagcag atagctatca attaagcttc     3060

atgattgaac cactaaatta g                                               3081


<210>  2
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  2

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  3
<211>  3081
<212>  DNA
<213>  Streptococcus thermophilus

<400>  3
atgaacatga ctgaaaaaat tcaaacttat ttaaacgatc caaagattgt tagcgttaat       60

actgttgatg ctcactcaga tcataagtat tttgaatctc ttgaagaatt ttctgaaggg      120

gagatgaagt taagacaatc tcttaatgga aaatggaaaa ttcactatgc tcagaataca      180

aatcaggttt taaaagactt ttataaaaca gaatttgatg aaactgattt gaatttcatc      240

aatgtaccag gtcatttaga gcttcaaggt tttggttctc cacaatatgt gaatacccaa      300

tatccttggg atggtaaaga attccttcgt ccacctcaag ttcctcaaga atcaaatgct      360

gttgcatcat acgttaaaca ttttaccttg aatgatgcat taaaagataa aaaagtattt      420

atctcattcc aaggggttgc tacttccatc tttgtatggg tcaatggtaa cttcgtagga      480

tacagtgaag attcatttac acctagtgaa tttgaaatta gtgattacct tgttgaaggt      540

gataacaagt tggcggtagc tgtttatcgt tattctacag caagctggtt ggaagaccaa      600

gacttctgga gactttacgg tatttttaga gatgtttact tgtatgctat tccaaaagtt      660

cacgttcaag atctctttgt taagggagat tatgattacc aaacaaaagc aggtcaattg      720

gatattgatt tgaagactgt tggtgattat gaagacaaga agattaaata tgttctttca      780

gattatgaag gcatcgttac agaaggtgat gcatctgtta atggtgacgg tgaactatct      840

gtaagtcttg aaaatcttaa aatcaaacct tggagtgctg aaagtcctaa actttacgat      900

ttgatccttc atgttttgga tgatgaccaa gttgttgaag tcgttccagt taaagttgga      960

tttagacgct ttgaaattaa agataaactt atgcttttga atggtaagag aattgtcttt     1020

aaaggggtta acagacacga atttaacgct agaacaggat gttgtatcac tgaagaagat     1080

atgctttggg atatcaaagt gatgaaacaa cataacatca atgctgttcg tacttcacac     1140

tatcctaacc aaacacgttg gtatgaattg tgtgatgaat atggacttta tgttatcgat     1200

gaagccaacc ttgaaacaca cggtacatgg caaaaacttg gtctatgcga accttcatgg     1260

aatatcccag ctagtgaacc agaatggttg cctgcttgtt tggatcgtgc caataacatg     1320

ttccaacgcg ataagaacca cgctagtgtt atcatttggt cttgtggtaa tgaatcatat     1380

gctggtaaag atattgctga catggctgat tacttccgta gtgttgacaa tactcgtcca     1440

gttcactatg aaggtgttgc atggtgtcgt gagtttgatt acattacaga catcgaaagt     1500

cgtatgtatg cgaaaccagc tgatatcgaa gaatacctca caactggtaa actagttgat     1560

ctttcaagcg ttagtgataa acactttgct tcaggtaacc taactaacaa acctcaaaaa     1620

ccttatattt catgtgaata catgcacaca atgggtaact ctggtggtgg attgcaactc     1680

tacactgact tagagaaata tccagaatac caaggtggat ttatttggga cttcattgac     1740

caagctattt acaaaacact tccaaatggt agcgaattcc tatcatatgg tggtgactgg     1800

catgatagac cttctgacta cgaattttgt ggaaatggta tcgtctttgc agatcgtacc     1860

ctaactccaa aacttcaaac agttaaacat ctttactcta atattaagat tgctgttgat     1920

gaaaaatcag taactatcaa gaatgataat ctcttcgaag atctttctgc ttatactttc     1980

ctagctagag tttacgaaga tggtagaaaa gttagtgaaa gtgaatatca ctttgatgtt     2040

aaaccaggcg aagaagcaac attcccagtt aactttgtag tcgaggcttc aaattctgaa     2100

caaatttacg aagttgcttg tgttctgagg gaagcaactg aatgggctcc taaaggtcat     2160

gaaattgttc gtggtcaata tgttgttgaa aagattagca ctgaaacacc agttaaagca     2220

cctttgaatg ttgttgaagg cgacttcaac atcggtattc aaggacaaaa cttctcaatc     2280

ttgctttcac gtgcacaaaa tactttagta tctgctaagt ataatggtgt tgaattcatt     2340

gagaaaggtc ctaaacttag cttcactcgt gcttacactg acaacgatcg tggtgctgga     2400

tatccattcg aaatggcagg ctggaaggtt gctggaaact atagtaaagt tacagatact     2460

caaattcaaa tcgaagacga ctctgttaaa gtgacttatg ttcatgaatt gccaggcttg     2520

tctgatgtcg aagttaaggt aacttatcaa gttgattaca agggtcgaat ctttgttact     2580

gcaaactatg atggtaaagc aggtttgcca aacttccctg aatttggtct agaatttgct     2640

atcggttcac aatttacaaa ccttagctat tatggatacg gtgcagaaga aagctaccgt     2700

gataaacttc ctggtgccta tcttggtcga tatgaaacat ctgttgaaaa gacatttgct     2760

ccatatctaa tgccacaaga atctggtaat cactatggta ctcgtgaatt cacagtatct     2820

gatgataacc ataatggtct taaattcacc gcacttaata aagcattcga attcagtgct     2880

ttgcgtaaca gtactgaaca aattgaaaat gctcgtcacc aatatgagtt gcaagaatct     2940

gatgctacat ggattaaagt tcttgctgct caaatgggtg taggtggtga cgacacatgg     3000

ggtgctccag ttcatgacga attcttgctt agctcagcag atagctatca attaagcttc     3060

atgattgaac cactaaatta g                                               3081


<210>  4
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  4

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Cys Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  5
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  VARIANT
<222>  (354)..(354)
<223>  "Xaa" is any amino acid except Arg 

<400>  5

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Xaa Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  6
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  6

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Ala Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Thr Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Ile Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  7
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  VARIANT
<222>  (354)..(354)
<223>  "Xaa" is any amino acid except Arg 

<400>  7

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Ala Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Thr Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Ile Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Xaa Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  8
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  8

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Ala Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Thr Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Ile Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Cys Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  9
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  9

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Ile Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Ser Trp  Gly Ser Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  10
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  VARIANT
<222>  (354)..(354)
<223>  "Xaa" is any amino acid except Arg 

<400>  10

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Xaa Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Ile Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Ser Trp  Gly Ser Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  11
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  11

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Cys Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Ile Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Ser Trp  Gly Ser Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  12
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  12

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Ser Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  13
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  VARIANT
<222>  (354)..(354)
<223>  "Xaa" is any amino acid except Arg 

<400>  13

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Xaa Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Ser Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  14
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  14

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Cys Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Ser Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  15
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  15

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Lys Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  16
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  VARIANT
<222>  (354)..(354)
<223>  "Xaa" is any amino acid except Arg 

<400>  16

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Xaa Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Lys Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  17
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  17

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Cys Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Lys Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  18
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  18

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Phe Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  19
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  VARIANT
<222>  (354)..(354)
<223>  "Xaa" is any amino acid except Arg 

<400>  19

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Xaa Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Phe Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  20
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  20

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Cys Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Phe Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  21
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  21

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ser Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  22
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  VARIANT
<222>  (354)..(354)
<223>  "Xaa" is any amino acid except Arg 

<400>  22

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Xaa Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ser Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  23
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  23

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Cys Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ser Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  24
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  24

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Thr Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Ile Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  25
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  VARIANT
<222>  (354)..(354)
<223>  "Xaa" is any amino acid except Arg 

<400>  25

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Thr Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Ile Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Xaa Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  26
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  26

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Thr Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Ile Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Cys Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  27
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  27

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Val Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  28
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus


<220>
<221>  VARIANT
<222>  (354)..(354)
<223>  "Xaa" is any amino acid except Arg 

<400>  28

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Xaa Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Val Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  29
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus

<400>  29

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Cys Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Val Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  30
<211>  1905
<212>  DNA
<213>  Streptococcus thermophilus

<400>  30
atggaaaaat ctaaaggtca gatgaagtct cgtttatcct acgcagctgg tgcttttggt       60

aacgacgtct tctatgcaac cttgtcaaca tactttatca tgtttgtgac aactcacttg      120

tttaacacag gtgatccaaa gcaaaatagt cactacgtac tattaatcac taacattatc      180

tctattttgc gtatcttgga agtatttatc gatccattga tcggtaatat gattgataac      240

actaatacta agtatggtaa attcaaacca tgggtagttg gtggtggtat catcagttct      300

atcaccttgt tgcttctctt caccgattta ggtggtttga ataaaacaaa tcctttcttg      360

taccttgtac tttttggaat tatctacctt ataatggatg tcttctactc gattaaagat      420

atcggtttct ggtcaatgct tcctgccttg tctcttgaca gtcacgaacg tgaaaaaatg      480

gcaacttttg cccgtattgg ttctacgatt ggtgccaata ttgtaggtgt tgccatcatg      540

ccaatcgttt tgttcttctc tatgacgaac agtagtggct ctggagataa atctggatgg      600

ttctggtttg catttatcgt tgcactcatt ggtgtgatta catcaattgc tgttggtatt      660

ggtacacgtg aagttgagtc aaaacttcgt gataacaatg aaaaaactag ccttaaacaa      720

gtctttaaag ttcttggtaa aaacgaccaa ttgatgtggc tgtctctcgg atattggttc      780

tatggtcttg gtattaatac acttaatgct cttcaacttt attacttcac atttatcctt      840

ggtgattcag ggaaatactc aatcctttac ggattgaata cagttgttgg tttggtttca      900

gtttcactgt tccctagtct tgctggtaaa ttcaaccgta aacgtttgtt ctatggatgt      960

attgcagtaa tgctcggtgg tatcggaatc tttagtattg caggtacttc acttccaatg     1020

atcttgactg cagctgaact cttcttcatt ccacaacctc ttgtgttcct tgttatcctt     1080

atgattatct ctgactcagt agaatatggt caatggaaat tgggacaccg tgatgaatca     1140

cttactttgt cagttcgtcc acttgttgat aaacttggtg gtgcgatgtc aaactggctt     1200

gtttctacaa ttgccgtagc tgccggtatg acaacaggtg cctcagcatc aacaattaca     1260

acacatcaac agtctatttt taagcttagc atgtttggtt tcccagcagc agcaatgctt     1320

atcggtgcct tcattattgc tcgtaaaatc actttgactg aagcacgtca cgctaaaatt     1380

gttgaagaat tggaacatcg ctttagcgta gcaacttctg aaaatgaagt taaagctaac     1440

gtcgtatctc ttgtaacccc tacaactggt tatttggttg atctctcaag tgttaatgat     1500

gaacactttg cttcaggtag catgggtaaa ggtttcgcca ttaaacctac tgatggagct     1560

gtctttgcac caattagtgg taccattcgt caaattcttc ctactcgcca tgcagttggt     1620

attgaaagtg aagatggtgt cattgttctt atccacgttg gcatcggaac agttaaactt     1680

aatggtgaag gattcattag ttacgtagaa caaggtgatc gtgttgaagt tggacaaaaa     1740

cttcttgagt tctggtcacc aattattgag aaaaatggtc ttgatgacac agtacttgtc     1800

actgtaacta attcagaaaa attcagtgct ttccatcttg aacaaaaagt tggagaaaag     1860

gtagaagctt tgtctgaagt tattaccttc aaaaaaggag aataa                     1905


<210>  31
<211>  634
<212>  PRT
<213>  Streptococcus thermophilus

<400>  31

Met Glu Lys Ser Lys Gly Gln Met Lys Ser Arg Leu Ser Tyr Ala Ala 
1               5                   10                  15      


Gly Ala Phe Gly Asn Asp Val Phe Tyr Ala Thr Leu Ser Thr Tyr Phe 
            20                  25                  30          


Ile Met Phe Val Thr Thr His Leu Phe Asn Thr Gly Asp Pro Lys Gln 
        35                  40                  45              


Asn Ser His Tyr Val Leu Leu Ile Thr Asn Ile Ile Ser Ile Leu Arg 
    50                  55                  60                  


Ile Leu Glu Val Phe Ile Asp Pro Leu Ile Gly Asn Met Ile Asp Asn 
65                  70                  75                  80  


Thr Asn Thr Lys Tyr Gly Lys Phe Lys Pro Trp Val Val Gly Gly Gly 
                85                  90                  95      


Ile Ile Ser Ser Ile Thr Leu Leu Leu Leu Phe Thr Asp Leu Gly Gly 
            100                 105                 110         


Leu Asn Lys Thr Asn Pro Phe Leu Tyr Leu Val Leu Phe Gly Ile Ile 
        115                 120                 125             


Tyr Leu Ile Met Asp Val Phe Tyr Ser Ile Lys Asp Ile Gly Phe Trp 
    130                 135                 140                 


Ser Met Leu Pro Ala Leu Ser Leu Asp Ser His Glu Arg Glu Lys Met 
145                 150                 155                 160 


Ala Thr Phe Ala Arg Ile Gly Ser Thr Ile Gly Ala Asn Ile Val Gly 
                165                 170                 175     


Val Ala Ile Met Pro Ile Val Leu Phe Phe Ser Met Thr Asn Ser Ser 
            180                 185                 190         


Gly Ser Gly Asp Lys Ser Gly Trp Phe Trp Phe Ala Phe Ile Val Ala 
        195                 200                 205             


Leu Ile Gly Val Ile Thr Ser Ile Ala Val Gly Ile Gly Thr Arg Glu 
    210                 215                 220                 


Val Glu Ser Lys Leu Arg Asp Asn Asn Glu Lys Thr Ser Leu Lys Gln 
225                 230                 235                 240 


Val Phe Lys Val Leu Gly Lys Asn Asp Gln Leu Met Trp Leu Ser Leu 
                245                 250                 255     


Gly Tyr Trp Phe Tyr Gly Leu Gly Ile Asn Thr Leu Asn Ala Leu Gln 
            260                 265                 270         


Leu Tyr Tyr Phe Thr Phe Ile Leu Gly Asp Ser Gly Lys Tyr Ser Ile 
        275                 280                 285             


Leu Tyr Gly Leu Asn Thr Val Val Gly Leu Val Ser Val Ser Leu Phe 
    290                 295                 300                 


Pro Ser Leu Ala Gly Lys Phe Asn Arg Lys Arg Leu Phe Tyr Gly Cys 
305                 310                 315                 320 


Ile Ala Val Met Leu Gly Gly Ile Gly Ile Phe Ser Ile Ala Gly Thr 
                325                 330                 335     


Ser Leu Pro Met Ile Leu Thr Ala Ala Glu Leu Phe Phe Ile Pro Gln 
            340                 345                 350         


Pro Leu Val Phe Leu Val Ile Leu Met Ile Ile Ser Asp Ser Val Glu 
        355                 360                 365             


Tyr Gly Gln Trp Lys Leu Gly His Arg Asp Glu Ser Leu Thr Leu Ser 
    370                 375                 380                 


Val Arg Pro Leu Val Asp Lys Leu Gly Gly Ala Met Ser Asn Trp Leu 
385                 390                 395                 400 


Val Ser Thr Ile Ala Val Ala Ala Gly Met Thr Thr Gly Ala Ser Ala 
                405                 410                 415     


Ser Thr Ile Thr Thr His Gln Gln Ser Ile Phe Lys Leu Ser Met Phe 
            420                 425                 430         


Gly Phe Pro Ala Ala Ala Met Leu Ile Gly Ala Phe Ile Ile Ala Arg 
        435                 440                 445             


Lys Ile Thr Leu Thr Glu Ala Arg His Ala Lys Ile Val Glu Glu Leu 
    450                 455                 460                 


Glu His Arg Phe Ser Val Ala Thr Ser Glu Asn Glu Val Lys Ala Asn 
465                 470                 475                 480 


Val Val Ser Leu Val Thr Pro Thr Thr Gly Tyr Leu Val Asp Leu Ser 
                485                 490                 495     


Ser Val Asn Asp Glu His Phe Ala Ser Gly Ser Met Gly Lys Gly Phe 
            500                 505                 510         


Ala Ile Lys Pro Thr Asp Gly Ala Val Phe Ala Pro Ile Ser Gly Thr 
        515                 520                 525             


Ile Arg Gln Ile Leu Pro Thr Arg His Ala Val Gly Ile Glu Ser Glu 
    530                 535                 540                 


Asp Gly Val Ile Val Leu Ile His Val Gly Ile Gly Thr Val Lys Leu 
545                 550                 555                 560 


Asn Gly Glu Gly Phe Ile Ser Tyr Val Glu Gln Gly Asp Arg Val Glu 
                565                 570                 575     


Val Gly Gln Lys Leu Leu Glu Phe Trp Ser Pro Ile Ile Glu Lys Asn 
            580                 585                 590         


Gly Leu Asp Asp Thr Val Leu Val Thr Val Thr Asn Ser Glu Lys Phe 
        595                 600                 605             


Ser Ala Phe His Leu Glu Gln Lys Val Gly Glu Lys Val Glu Ala Leu 
    610                 615                 620                 


Ser Glu Val Ile Thr Phe Lys Lys Gly Glu 
625                 630                 


<210>  32
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  32
cttgactgca gctgaactc                                                    19


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  33
ctcgactaca aagttaactg g                                                 21


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  34
cagagttacc cattgtgtgc                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  35
aggttggctt catcgataac                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  36
catcaccttc tgtaacgatg c                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  37
gtaacttcgt aggatacagt g                                                 21


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  38
aggacgttgt atcactgaag                                                   20


