                         SEQUENCE LISTING

<110>  Icon Genetics GmbH
        
<120>  Norovirus-like particles with improved stability

<130>  PCT-17702

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  544
<212>  PRT
<213>  Norovirus

<400>  1

Met Met Met Ala Ser Lys Asp Ala Thr Pro Ser Ala Asp Gly Ala Thr 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Thr Ala Asp Pro Ile Pro 
            20                  25                  30          


Ile Asp Pro Val Ala Gly Ser Ser Thr Ala Leu Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Leu Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Val 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Val Ile Ile Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Gln Ser Arg Thr Leu Ser Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Val Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Tyr His Asn Asn Asp Thr Gln 
                165                 170                 175     


Pro Thr Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly 
            180                 185                 190         


Gly Ala Ser Gly Gly Thr Asp Ser Phe Val Val Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Gly Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr 
    210                 215                 220                 


Val Glu Gln Lys Thr Arg Pro Phe Thr Val Pro Asn Ile Pro Leu Lys 
225                 230                 235                 240 


Tyr Leu Ser Asn Ser Arg Ile Pro Asn Pro Ile Glu Gly Met Ser Leu 
                245                 250                 255     


Ser Pro Asp Gln Thr Gln Asn Val Gln Phe Gln Asn Gly Arg Cys Thr 
            260                 265                 270         


Ile Asp Gly Gln Pro Leu Gly Thr Thr Pro Val Ser Val Ser Gln Leu 
        275                 280                 285             


Cys Lys Phe Arg Gly Arg Ile Thr Ser Gly Gln Arg Val Leu Asn Leu 
    290                 295                 300                 


Thr Glu Leu Asp Gly Ser Pro Phe Met Ala Phe Ala Ala Pro Ala Pro 
305                 310                 315                 320 


Ala Gly Phe Pro Asp Leu Gly Ser Cys Asp Trp His Ile Glu Met Ser 
                325                 330                 335     


Lys Ile Pro Asn Ser Ser Thr Gln Asn Asn Pro Ile Val Thr Asn Ser 
            340                 345                 350         


Val Lys Pro Asn Ser Gln Gln Phe Val Pro His Leu Ser Ser Ile Thr 
        355                 360                 365             


Leu Asp Glu Asn Val Ser Ser Gly Gly Asp Tyr Ile Gly Thr Ile Gln 
    370                 375                 380                 


Trp Thr Ser Pro Pro Ser Asp Ser Gly Gly Ala Asn Thr Asn Phe Trp 
385                 390                 395                 400 


Lys Ile Pro Asp Tyr Gly Ser Ser Leu Ala Glu Ala Ser Gln Leu Ala 
                405                 410                 415     


Pro Ala Val Tyr Pro Pro Gly Phe Asn Glu Val Ile Val Tyr Phe Met 
            420                 425                 430         


Ala Ser Ile Pro Gly Pro Asn Gln Ser Gly Ser Pro Asn Leu Val Pro 
        435                 440                 445             


Cys Leu Leu Pro Gln Glu Tyr Ile Thr His Phe Ile Ser Glu Gln Ala 
    450                 455                 460                 


Pro Ile Gln Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr 
465                 470                 475                 480 


Asn Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Gly Gly Tyr Leu Thr 
                485                 490                 495     


Cys Val Pro Asn Ser Ser Ser Thr Gly Pro Gln Gln Leu Pro Leu Asp 
            500                 505                 510         


Gly Val Phe Val Phe Ala Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys 
        515                 520                 525             


Pro Val Gly Thr Ala Gly Pro Ala Arg Gly Arg Leu Gly Val Arg Arg 
    530                 535                 540                 


<210>  2
<211>  540
<212>  PRT
<213>  Norovirus

<400>  2

Met Ala Ser Lys Asp Ala Thr Pro Ser Ala Asp Gly Ala Thr Gly Ala 
1               5                   10                  15      


Gly Gln Leu Val Pro Glu Val Asn Thr Ala Asp Pro Ile Pro Ile Asp 
            20                  25                  30          


Pro Val Ala Gly Ser Ser Thr Ala Leu Ala Thr Ala Gly Gln Val Asn 
        35                  40                  45              


Leu Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro Gln Gly 
    50                  55                  60                  


Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu Phe Asp 
65                  70                  75                  80  


Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu Ser Gln 
                85                  90                  95      


Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Val Leu Ala 
            100                 105                 110         


Gly Asn Ala Phe Thr Ala Gly Lys Val Ile Ile Cys Cys Val Pro Pro 
        115                 120                 125             


Gly Phe Gln Ser Arg Thr Leu Ser Ile Ala Gln Ala Thr Leu Phe Pro 
    130                 135                 140                 


His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Val Glu Val Pro Leu 
145                 150                 155                 160 


Glu Asp Val Arg Asn Val Leu Tyr His Asn Asn Asp Thr Gln Pro Thr 
                165                 170                 175     


Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly Gly Ala 
            180                 185                 190         


Ser Gly Gly Thr Asp Ser Phe Val Val Ala Gly Arg Val Leu Thr Cys 
        195                 200                 205             


Pro Gly Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val Glu 
    210                 215                 220                 


Gln Lys Thr Arg Pro Phe Thr Val Pro Asn Ile Pro Leu Lys Tyr Leu 
225                 230                 235                 240 


Ser Asn Ser Arg Ile Pro Asn Pro Ile Glu Gly Met Ser Leu Ser Pro 
                245                 250                 255     


Asp Gln Thr Gln Asn Val Gln Phe Gln Asn Gly Arg Cys Thr Ile Asp 
            260                 265                 270         


Gly Gln Pro Leu Gly Thr Thr Pro Val Ser Val Ser Gln Leu Cys Lys 
        275                 280                 285             


Phe Arg Gly Arg Ile Thr Ser Gly Gln Arg Val Leu Asn Leu Thr Glu 
    290                 295                 300                 


Leu Asp Gly Ser Pro Phe Met Ala Phe Ala Ala Pro Ala Pro Ala Gly 
305                 310                 315                 320 


Phe Pro Asp Leu Gly Ser Cys Asp Trp His Ile Glu Met Ser Lys Ile 
                325                 330                 335     


Pro Asn Ser Ser Thr Gln Asn Asn Pro Ile Val Thr Asn Ser Val Lys 
            340                 345                 350         


Pro Asn Ser Gln Gln Phe Val Pro His Leu Ser Ser Ile Thr Leu Asp 
        355                 360                 365             


Glu Asn Val Ser Ser Gly Gly Asp Tyr Ile Gly Thr Ile Gln Trp Thr 
    370                 375                 380                 


Ser Pro Pro Ser Asp Ser Gly Gly Ala Asn Thr Asn Phe Trp Lys Ile 
385                 390                 395                 400 


Pro Asp Tyr Gly Ser Ser Leu Ala Glu Ala Ser Gln Leu Ala Pro Ala 
                405                 410                 415     


Val Tyr Pro Pro Gly Phe Asn Glu Val Ile Val Tyr Phe Met Ala Ser 
            420                 425                 430         


Ile Pro Gly Pro Asn Gln Ser Gly Ser Pro Asn Leu Val Pro Cys Leu 
        435                 440                 445             


Leu Pro Gln Glu Tyr Ile Thr His Phe Ile Ser Glu Gln Ala Pro Ile 
    450                 455                 460                 


Gln Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr Asn Arg 
465                 470                 475                 480 


Asn Leu Gly Glu Phe Lys Leu Tyr Pro Gly Gly Tyr Leu Thr Cys Val 
                485                 490                 495     


Pro Asn Ser Ser Ser Thr Gly Pro Gln Gln Leu Pro Leu Asp Gly Val 
            500                 505                 510         


Phe Val Phe Ala Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val 
        515                 520                 525             


Gly Thr Ala Gly Pro Ala Arg Gly Arg Leu Gly Val 
    530                 535                 540 


<210>  3
<211>  540
<212>  PRT
<213>  artificial

<220>
<223>  H472R MUTATION

<400>  3

Met Ala Ser Lys Asp Ala Thr Pro Ser Ala Asp Gly Ala Thr Gly Ala 
1               5                   10                  15      


Gly Gln Leu Val Pro Glu Val Asn Thr Ala Asp Pro Ile Pro Ile Asp 
            20                  25                  30          


Pro Val Ala Gly Ser Ser Thr Ala Leu Ala Thr Ala Gly Gln Val Asn 
        35                  40                  45              


Leu Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro Gln Gly 
    50                  55                  60                  


Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu Phe Asp 
65                  70                  75                  80  


Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu Ser Gln 
                85                  90                  95      


Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Val Leu Ala 
            100                 105                 110         


Gly Asn Ala Phe Thr Ala Gly Lys Val Ile Ile Cys Cys Val Pro Pro 
        115                 120                 125             


Gly Phe Gln Ser Arg Thr Leu Ser Ile Ala Gln Ala Thr Leu Phe Pro 
    130                 135                 140                 


His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Val Glu Val Pro Leu 
145                 150                 155                 160 


Glu Asp Val Arg Asn Val Leu Tyr His Asn Asn Asp Thr Gln Pro Thr 
                165                 170                 175     


Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly Gly Ala 
            180                 185                 190         


Ser Gly Gly Thr Asp Ser Phe Val Val Ala Gly Arg Val Leu Thr Cys 
        195                 200                 205             


Pro Gly Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val Glu 
    210                 215                 220                 


Gln Lys Thr Arg Pro Phe Thr Val Pro Asn Ile Pro Leu Lys Tyr Leu 
225                 230                 235                 240 


Ser Asn Ser Arg Ile Pro Asn Pro Ile Glu Gly Met Ser Leu Ser Pro 
                245                 250                 255     


Asp Gln Thr Gln Asn Val Gln Phe Gln Asn Gly Arg Cys Thr Ile Asp 
            260                 265                 270         


Gly Gln Pro Leu Gly Thr Thr Pro Val Ser Val Ser Gln Leu Cys Lys 
        275                 280                 285             


Phe Arg Gly Arg Ile Thr Ser Gly Gln Arg Val Leu Asn Leu Thr Glu 
    290                 295                 300                 


Leu Asp Gly Ser Pro Phe Met Ala Phe Ala Ala Pro Ala Pro Ala Gly 
305                 310                 315                 320 


Phe Pro Asp Leu Gly Ser Cys Asp Trp His Ile Glu Met Ser Lys Ile 
                325                 330                 335     


Pro Asn Ser Ser Thr Gln Asn Asn Pro Ile Val Thr Asn Ser Val Lys 
            340                 345                 350         


Pro Asn Ser Gln Gln Phe Val Pro His Leu Ser Ser Ile Thr Leu Asp 
        355                 360                 365             


Glu Asn Val Ser Ser Gly Gly Asp Tyr Ile Gly Thr Ile Gln Trp Thr 
    370                 375                 380                 


Ser Pro Pro Ser Asp Ser Gly Gly Ala Asn Thr Asn Phe Trp Lys Ile 
385                 390                 395                 400 


Pro Asp Tyr Gly Ser Ser Leu Ala Glu Ala Ser Gln Leu Ala Pro Ala 
                405                 410                 415     


Val Tyr Pro Pro Gly Phe Asn Glu Val Ile Val Tyr Phe Met Ala Ser 
            420                 425                 430         


Ile Pro Gly Pro Asn Gln Ser Gly Ser Pro Asn Leu Val Pro Cys Leu 
        435                 440                 445             


Leu Pro Gln Glu Tyr Ile Thr His Phe Ile Ser Glu Gln Ala Pro Ile 
    450                 455                 460                 


Gln Gly Glu Ala Ala Leu Leu Arg Tyr Val Asp Pro Asp Thr Asn Arg 
465                 470                 475                 480 


Asn Leu Gly Glu Phe Lys Leu Tyr Pro Gly Gly Tyr Leu Thr Cys Val 
                485                 490                 495     


Pro Asn Ser Ser Ser Thr Gly Pro Gln Gln Leu Pro Leu Asp Gly Val 
            500                 505                 510         


Phe Val Phe Ala Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val 
        515                 520                 525             


Gly Thr Ala Gly Pro Ala Arg Gly Arg Leu Gly Val 
    530                 535                 540 


<210>  4
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T39K, T43D, H472R MUTATIONS

<400>  4

Met Ala Ser Lys Asp Ala Thr Pro Ser Ala Asp Gly Ala Thr Gly Ala 
1               5                   10                  15      


Gly Gln Leu Val Pro Glu Val Asn Thr Ala Asp Pro Ile Pro Ile Asp 
            20                  25                  30          


Pro Val Ala Gly Ser Ser Lys Ala Leu Ala Asp Ala Gly Gln Val Asn 
        35                  40                  45              


Leu Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro Gln Gly 
    50                  55                  60                  


Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu Phe Asp 
65                  70                  75                  80  


Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu Ser Gln 
                85                  90                  95      


Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Val Leu Ala 
            100                 105                 110         


Gly Asn Ala Phe Thr Ala Gly Lys Val Ile Ile Cys Cys Val Pro Pro 
        115                 120                 125             


Gly Phe Gln Ser Arg Thr Leu Ser Ile Ala Gln Ala Thr Leu Phe Pro 
    130                 135                 140                 


His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Val Glu Val Pro Leu 
145                 150                 155                 160 


Glu Asp Val Arg Asn Val Leu Tyr His Asn Asn Asp Thr Gln Pro Thr 
                165                 170                 175     


Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly Gly Ala 
            180                 185                 190         


Ser Gly Gly Thr Asp Ser Phe Val Val Ala Gly Arg Val Leu Thr Cys 
        195                 200                 205             


Pro Gly Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val Glu 
    210                 215                 220                 


Gln Lys Thr Arg Pro Phe Thr Val Pro Asn Ile Pro Leu Lys Tyr Leu 
225                 230                 235                 240 


Ser Asn Ser Arg Ile Pro Asn Pro Ile Glu Gly Met Ser Leu Ser Pro 
                245                 250                 255     


Asp Gln Thr Gln Asn Val Gln Phe Gln Asn Gly Arg Cys Thr Ile Asp 
            260                 265                 270         


Gly Gln Pro Leu Gly Thr Thr Pro Val Ser Val Ser Gln Leu Cys Lys 
        275                 280                 285             


Phe Arg Gly Arg Ile Thr Ser Gly Gln Arg Val Leu Asn Leu Thr Glu 
    290                 295                 300                 


Leu Asp Gly Ser Pro Phe Met Ala Phe Ala Ala Pro Ala Pro Ala Gly 
305                 310                 315                 320 


Phe Pro Asp Leu Gly Ser Cys Asp Trp His Ile Glu Met Ser Lys Ile 
                325                 330                 335     


Pro Asn Ser Ser Thr Gln Asn Asn Pro Ile Val Thr Asn Ser Val Lys 
            340                 345                 350         


Pro Asn Ser Gln Gln Phe Val Pro His Leu Ser Ser Ile Thr Leu Asp 
        355                 360                 365             


Glu Asn Val Ser Ser Gly Gly Asp Tyr Ile Gly Thr Ile Gln Trp Thr 
    370                 375                 380                 


Ser Pro Pro Ser Asp Ser Gly Gly Ala Asn Thr Asn Phe Trp Lys Ile 
385                 390                 395                 400 


Pro Asp Tyr Gly Ser Ser Leu Ala Glu Ala Ser Gln Leu Ala Pro Ala 
                405                 410                 415     


Val Tyr Pro Pro Gly Phe Asn Glu Val Ile Val Tyr Phe Met Ala Ser 
            420                 425                 430         


Ile Pro Gly Pro Asn Gln Ser Gly Ser Pro Asn Leu Val Pro Cys Leu 
        435                 440                 445             


Leu Pro Gln Glu Tyr Ile Thr His Phe Ile Ser Glu Gln Ala Pro Ile 
    450                 455                 460                 


Gln Gly Glu Ala Ala Leu Leu Arg Tyr Val Asp Pro Asp Thr Asn Arg 
465                 470                 475                 480 


Asn Leu Gly Glu Phe Lys Leu Tyr Pro Gly Gly Tyr Leu Thr Cys Val 
                485                 490                 495     


Pro Asn Ser Ser Ser Thr Gly Pro Gln Gln Leu Pro Leu Asp Gly Val 
            500                 505                 510         


Phe Val Phe Ala Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val 
        515                 520                 525             


Gly Thr Ala Gly Pro Ala Arg Gly Arg Leu Gly Val 
    530                 535                 540 


<210>  5
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T39D, T43K, H472R MUTATIONS

<400>  5

Met Ala Ser Lys Asp Ala Thr Pro Ser Ala Asp Gly Ala Thr Gly Ala 
1               5                   10                  15      


Gly Gln Leu Val Pro Glu Val Asn Thr Ala Asp Pro Ile Pro Ile Asp 
            20                  25                  30          


Pro Val Ala Gly Ser Ser Asp Ala Leu Ala Lys Ala Gly Gln Val Asn 
        35                  40                  45              


Leu Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro Gln Gly 
    50                  55                  60                  


Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu Phe Asp 
65                  70                  75                  80  


Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu Ser Gln 
                85                  90                  95      


Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Val Leu Ala 
            100                 105                 110         


Gly Asn Ala Phe Thr Ala Gly Lys Val Ile Ile Cys Cys Val Pro Pro 
        115                 120                 125             


Gly Phe Gln Ser Arg Thr Leu Ser Ile Ala Gln Ala Thr Leu Phe Pro 
    130                 135                 140                 


His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Val Glu Val Pro Leu 
145                 150                 155                 160 


Glu Asp Val Arg Asn Val Leu Tyr His Asn Asn Asp Thr Gln Pro Thr 
                165                 170                 175     


Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly Gly Ala 
            180                 185                 190         


Ser Gly Gly Thr Asp Ser Phe Val Val Ala Gly Arg Val Leu Thr Cys 
        195                 200                 205             


Pro Gly Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val Glu 
    210                 215                 220                 


Gln Lys Thr Arg Pro Phe Thr Val Pro Asn Ile Pro Leu Lys Tyr Leu 
225                 230                 235                 240 


Ser Asn Ser Arg Ile Pro Asn Pro Ile Glu Gly Met Ser Leu Ser Pro 
                245                 250                 255     


Asp Gln Thr Gln Asn Val Gln Phe Gln Asn Gly Arg Cys Thr Ile Asp 
            260                 265                 270         


Gly Gln Pro Leu Gly Thr Thr Pro Val Ser Val Ser Gln Leu Cys Lys 
        275                 280                 285             


Phe Arg Gly Arg Ile Thr Ser Gly Gln Arg Val Leu Asn Leu Thr Glu 
    290                 295                 300                 


Leu Asp Gly Ser Pro Phe Met Ala Phe Ala Ala Pro Ala Pro Ala Gly 
305                 310                 315                 320 


Phe Pro Asp Leu Gly Ser Cys Asp Trp His Ile Glu Met Ser Lys Ile 
                325                 330                 335     


Pro Asn Ser Ser Thr Gln Asn Asn Pro Ile Val Thr Asn Ser Val Lys 
            340                 345                 350         


Pro Asn Ser Gln Gln Phe Val Pro His Leu Ser Ser Ile Thr Leu Asp 
        355                 360                 365             


Glu Asn Val Ser Ser Gly Gly Asp Tyr Ile Gly Thr Ile Gln Trp Thr 
    370                 375                 380                 


Ser Pro Pro Ser Asp Ser Gly Gly Ala Asn Thr Asn Phe Trp Lys Ile 
385                 390                 395                 400 


Pro Asp Tyr Gly Ser Ser Leu Ala Glu Ala Ser Gln Leu Ala Pro Ala 
                405                 410                 415     


Val Tyr Pro Pro Gly Phe Asn Glu Val Ile Val Tyr Phe Met Ala Ser 
            420                 425                 430         


Ile Pro Gly Pro Asn Gln Ser Gly Ser Pro Asn Leu Val Pro Cys Leu 
        435                 440                 445             


Leu Pro Gln Glu Tyr Ile Thr His Phe Ile Ser Glu Gln Ala Pro Ile 
    450                 455                 460                 


Gln Gly Glu Ala Ala Leu Leu Arg Tyr Val Asp Pro Asp Thr Asn Arg 
465                 470                 475                 480 


Asn Leu Gly Glu Phe Lys Leu Tyr Pro Gly Gly Tyr Leu Thr Cys Val 
                485                 490                 495     


Pro Asn Ser Ser Ser Thr Gly Pro Gln Gln Leu Pro Leu Asp Gly Val 
            500                 505                 510         


Phe Val Phe Ala Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val 
        515                 520                 525             


Gly Thr Ala Gly Pro Ala Arg Gly Arg Leu Gly Val 
    530                 535                 540 


<210>  6
<211>  539
<212>  PRT
<213>  Norovirus

<400>  6

Met Met Met Ala Ser Lys Asp Ala Pro Thr Ser Pro Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Ala Asn Thr Ala Glu Gln Ile Ser 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ala Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Phe Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ala His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Leu 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Ile Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Asp Ala Arg Ile Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Leu Ile Ala Asp Val Arg Thr Leu Glu Pro Val Glu Leu 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Tyr His Asn Ser Ser Gln Pro 
                165                 170                 175     


Gln Pro Thr Met Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Thr Asp Ala Phe Val Val Ala Gly Arg Val 
        195                 200                 205             


Leu Thr Cys Pro Ala Pro Asp Phe Ser Phe Leu Phe Leu Val Pro Pro 
    210                 215                 220                 


Ser Val Glu Gln Lys Thr Arg Val Phe Ser Val Pro Asn Ile Pro Leu 
225                 230                 235                 240 


Lys Asp Leu Ser Asn Ser Arg Val Pro Val Pro Ile Gln Gly Met Phe 
                245                 250                 255     


Met Ser Pro Asp Val Asn Gln Ser Val Gln Phe Gln Asn Gly Arg Cys 
            260                 265                 270         


Gln Ile Asp Gly Gln Leu Gln Gly Thr Thr Pro Val Ser Leu Ser Gln 
        275                 280                 285             


Leu Cys Lys Ile Arg Gly Lys Thr Ser Ser Asn Ala Arg Val Leu Asn 
    290                 295                 300                 


Leu Ser Glu Val Asp Gly Thr Pro Phe Ile Pro Leu Glu Ser Pro Ala 
305                 310                 315                 320 


Pro Val Gly Phe Pro Asp Leu Gly Gly Cys Asp Trp His Val Asn Phe 
                325                 330                 335     


Ser Phe Gln Thr Gln Asp Arg Asp Pro Ser Gln Ser Val Thr Phe Ala 
            340                 345                 350         


Thr Asn Asp Ala Ser Phe Val Pro Tyr Leu Gly Ser Val Ser Pro His 
        355                 360                 365             


Asn Gly Glu Gly Phe Gln Ala Gly Asp Ile Ile Gly Ser Leu Gly Trp 
    370                 375                 380                 


Ile Ser Ala Pro Ser Asp Asn Ser Gln Phe Asn Val Trp Ala Ile Pro 
385                 390                 395                 400 


Lys Tyr Gly Ser Ser Leu Gln Met Ser Pro Ile Leu Leu Leu Leu Cys 
                405                 410                 415     


Ser Pro Arg Leu Trp Glu Val Ile Leu Tyr Phe Tyr Ser Thr Phe Pro 
            420                 425                 430         


Gly Ser Gly Gln Pro Ser Gln Leu Gln Val Pro Cys Leu Leu Pro Gln 
        435                 440                 445             


Glu Phe Ile Thr His Phe Cys Asn Glu Gln Ala Pro Ile Ala Gly Glu 
    450                 455                 460                 


Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr Gly Arg Asn Leu Gly 
465                 470                 475                 480 


Glu Phe Lys Leu Tyr Pro Asp Gly Phe Met Thr Cys Val Pro Asn Ser 
                485                 490                 495     


Val Ser Ser Gly Pro Gln Thr Leu Pro Ile Asn Gly Val Phe Val Phe 
            500                 505                 510         


Val Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val Gly Thr Ala 
        515                 520                 525             


Ser Ala Ala Arg Arg Leu Gly Leu Arg Arg Ile 
    530                 535                 


<210>  7
<211>  544
<212>  PRT
<213>  Norovirus

<400>  7

Met Met Met Ala Ser Lys Asp Ala Pro Thr Asn Met Asp Gly Thr Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Ala Asn Thr Ala Glu Pro Ile Ser 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ala Ala Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Ile Asn Met Ile Asp Pro Trp Ile Met Ser Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Val Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro Gln Leu Asn Pro Phe Leu Ala His Leu 
                85                  90                  95      


Ala Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Lys Val Leu 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Ile Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Thr Ser Gln Asn Ile Ser Ile Ala Gln Met Thr Met 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Val Leu Glu Pro Ile Glu Ile 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Thr Asn Asp Asn Arg 
                165                 170                 175     


Pro Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Ala Asn 
            180                 185                 190         


Gly Ser Ser Ser Gly Thr Asp Pro Phe Val Ile Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Asp Ser Asn Phe Ser Phe Leu Phe Leu Val Pro Pro Asn 
    210                 215                 220                 


Val Glu Gln Lys Thr Arg Pro Phe Ser Val Pro Asn Ile Pro Leu Asn 
225                 230                 235                 240 


Thr Leu Ser Asn Ser Arg Val Pro Ser Leu Ile Lys Ser Met Thr Ile 
                245                 250                 255     


Ser Arg Asp Gln Asn Gln Ile Ile Gln Phe Gln Asn Gly Arg Val Thr 
            260                 265                 270         


Leu Asp Gly Gln Leu Gln Gly Thr Thr Pro Thr Ser Val Ser Gln Leu 
        275                 280                 285             


Cys Lys Ile Arg Gly Thr Thr Tyr His Ala Thr Gly Gly Asn Gly Ile 
    290                 295                 300                 


Asn Leu Thr Glu Leu Asn Gly Glu Pro Tyr His Ala Phe Glu Ser Pro 
305                 310                 315                 320 


Ala Pro Ile Gly Phe Pro Asp Leu Gly Gly Cys Asp Trp His Leu Thr 
                325                 330                 335     


Ala Thr Pro Thr Gln Ala Phe Asn Asp Gly Ala Lys Val Val Arg Leu 
            340                 345                 350         


Ser Val Thr Gln Gly Ala Ala Phe Ala Pro His Leu Gly Thr Ile His 
        355                 360                 365             


Tyr Thr Thr Thr Asp His Asp Tyr Asp Pro Asn Thr Ser Ile Ile Cys 
    370                 375                 380                 


Thr Leu Asp Trp Leu Ser Gln Thr Thr Gly Gln Asn Asn Val Asp Pro 
385                 390                 395                 400 


Trp Gln Ile Pro Thr Tyr Gly Ser Thr Leu Thr Glu Ala Ala Gln Leu 
                405                 410                 415     


Ala Pro Pro Ile Phe Pro Pro Gly Phe Gly Glu Thr Leu Val Phe Phe 
            420                 425                 430         


Leu Ser Asp Phe Pro Ile Ser Asn Gly Lys Asn Gly Leu Ser Val Pro 
        435                 440                 445             


Cys Thr Leu Pro Gln Glu Phe Val Thr His Phe Val Asn Glu Gln Ala 
    450                 455                 460                 


Pro Ile Arg Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr 
465                 470                 475                 480 


His Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Glu Gly Phe Met Thr 
                485                 490                 495     


Cys Val Pro Asn Thr Ser Gly Gly Gly Pro Gln Thr Leu Pro Ile Asn 
            500                 505                 510         


Gly Val Phe Val Phe Val Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys 
        515                 520                 525             


Pro Val Gly Thr Ala Gly Ala Ala Arg Arg Leu Gly Ile Arg Arg Ser 
    530                 535                 540                 


<210>  8
<211>  545
<212>  PRT
<213>  Norovirus

<400>  8

Met Met Met Ala Ser Lys Asp Ala Pro Thr Asn Met Asp Gly Thr Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Ala Asn Thr Ala Glu Pro Ile Ser 
            20                  25                  30          


Met Glu Pro Val Ala Gly Ala Ala Thr Ala Ala Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Met Asn Asn Tyr Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu 
                85                  90                  95      


Ala Gln Met Tyr Asn Gly Trp Val Gly Asn Met Lys Val Lys Val Leu 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Ile Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Ala Ala Gln Asn Ile Ser Ile Ala Gln Ala Thr Met 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Val Leu Glu Pro Ile Glu Ile 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Asn Thr 
                165                 170                 175     


Pro Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Ala Ser 
            180                 185                 190         


Gly Ser Ser Ser Gly Thr Asp Pro Phe Val Ile Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Ser Pro Asp Phe Ser Phe Leu Phe Leu Val Pro Pro Asn 
    210                 215                 220                 


Val Glu Gln Lys Thr Lys Pro Phe Ser Val Pro Asn Leu Pro Leu Asn 
225                 230                 235                 240 


Ile Leu Ser Ser Ser Arg Val Pro Ser Leu Ile Lys Ser Met Met Ile 
                245                 250                 255     


Ser Arg Asp His Gly Gln Met Val Gln Phe Gln Asn Gly Arg Val Thr 
            260                 265                 270         


Leu Asp Gly Gln Leu Gln Gly Thr Thr Pro Thr Ser Ala Ser Gln Leu 
        275                 280                 285             


Cys Lys Ile Arg Gly Ser Val Phe His Ala Asn Gly Gly Asn Gly Tyr 
    290                 295                 300                 


Asn Leu Thr Glu Leu Asp Gly Ser Pro Tyr His Ala Phe Glu Ser Pro 
305                 310                 315                 320 


Ala Pro Ile Gly Phe Pro Asp Leu Gly Glu Cys Asp Trp His Met Glu 
                325                 330                 335     


Ala Ser Pro Thr Ile Gln Phe Asp Thr Gly Asp Val Ile Lys Gln Ile 
            340                 345                 350         


Asn Val Lys Gln Glu Ser Ala Phe Ala Pro His Leu Gly Thr Val Gln 
        355                 360                 365             


Ala Asp Gly Leu Asp Gly Val Ser Ala Asn Thr Asn Met Ile Ala Lys 
    370                 375                 380                 


Leu Gly Trp Val Ser Pro Val Ser Asp Gly His Arg Arg Asp Val Asp 
385                 390                 395                 400 


Pro Trp Val Ile Pro Arg Tyr Gly Ser Thr Leu Thr Glu Ala Ala Gln 
                405                 410                 415     


Leu Ala Pro Pro Ile Tyr Pro Pro Gly Phe Gly Glu Ala Ile Val Phe 
            420                 425                 430         


Phe Met Ser Asp Phe Pro Ile Ala His Gly Thr Asn Gly Leu Ser Val 
        435                 440                 445             


Pro Cys Thr Ile Pro Gln Glu Phe Val Thr His Phe Val Asn Glu Gln 
    450                 455                 460                 


Ala Pro Thr Arg Gly Glu Ala Ala Leu Leu His Tyr Leu Asp Pro Asp 
465                 470                 475                 480 


Thr His Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Asp Gly Phe Met 
                485                 490                 495     


Thr Cys Val Pro Asn Ser Ser Gly Ser Gly Pro Gln Thr Leu Pro Ile 
            500                 505                 510         


Asn Gly Val Phe Val Phe Val Ser Trp Val Ser Arg Phe Tyr Gln Leu 
        515                 520                 525             


Lys Pro Val Gly Thr Ala Gly Pro Ala Arg Arg Leu Gly Ile Arg Arg 
    530                 535                 540                 


Ser 
545 


<210>  9
<211>  545
<212>  PRT
<213>  Norovirus

<400>  9

Met Met Met Ala Ser Lys Asp Ala Pro Ser Asn Met Asp Gly Thr Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Ala Asn Thr Ala Glu Pro Ile Asn 
            20                  25                  30          


Met Glu Ser Val Val Gly Ala Ala Thr Ala Thr Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Leu Ile Asp Pro Trp Ile Met Asn Asn Tyr Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu 
                85                  90                  95      


Ser Arg Met Tyr Asn Gly Trp Val Gly Asn Met Lys Val Arg Val Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Ser Ala Gly Lys Ile Ile Ile Cys Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Thr Ser Gln Ser Ile Ser Ile Ala Gln Ala Thr Met 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Val Leu Glu Pro Ile Asp Val 
145                 150                 155                 160 


Pro Leu Asp Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Asn Ala 
                165                 170                 175     


Gln Thr Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly 
            180                 185                 190         


Ala Ser Ser Ser Gly Ser Asp Pro Phe Val Ile Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Thr Gln Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Asp 
    210                 215                 220                 


Val Glu Gln Lys Thr Lys Pro Phe Ser Val Pro Asn Ile Pro Leu Asn 
225                 230                 235                 240 


Leu Met Ser Asn Ser Arg Val Pro Ala Leu Ile Asp Gly Met Thr Val 
                245                 250                 255     


Ser Ser Asp Gln Asn Gln Val Val Gln Phe Gln Asn Gly Arg Val Thr 
            260                 265                 270         


Leu Asp Gly Gln Leu Gln Gly Thr Thr Ala Val Ser Ala Ser Cys Val 
        275                 280                 285             


Ala Lys Ile Arg Gly Arg Ile Phe Ser Asn Ala Ser His Tyr Gly Ile 
    290                 295                 300                 


Asn Leu Thr Glu Val Asp Gly Thr Gln Tyr His Ala Phe Asp Ser Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Phe Pro Asp Phe Gly Asn Cys Asp Trp His Val Thr 
                325                 330                 335     


Gly Thr Lys Ala Ser Gln Gly Asp Leu Gln Thr Asp Asn Pro Thr Ile 
            340                 345                 350         


Ser Gly Thr Ile Lys Ser Tyr Glu Ser Ser Phe Ala Pro His Leu Gly 
        355                 360                 365             


Thr Val Arg Ile Glu Gly Asp Asp Asn Glu Leu Ala Arg Phe Asn Gly 
    370                 375                 380                 


Lys Asp Val Leu Leu Asn Leu Thr Trp Phe Ser Gln Arg Asn Gly Ser 
385                 390                 395                 400 


Gln Leu Asn Leu Trp Thr Ile Pro Ser Tyr Gly Ser Asn Leu Thr Glu 
                405                 410                 415     


Ala Ser Gln Leu Ala Pro Pro Ile Tyr Pro Pro Gly Phe Gly Glu Ala 
            420                 425                 430         


Ile Val Tyr Phe Thr Ser Thr Phe Pro Ala Ile Ser Arg Pro Ser Val 
        435                 440                 445             


Pro Cys Thr Met Pro Gln Glu Phe Val Ser His Phe Val Asn Glu Gln 
    450                 455                 460                 


Ala Pro Thr Arg Gly Glu Ala Ala Leu Leu His Tyr Leu Asp Pro Asp 
465                 470                 475                 480 


Thr His Arg Asn Leu Gly Glu Phe Lys Met Tyr Pro Glu Gly Phe Phe 
                485                 490                 495     


Thr Cys Val Pro Asn Ala Gly Gly Ser Gly Pro Gln Thr Leu Pro Ile 
            500                 505                 510         


Asn Gly Val Phe Val Phe Val Ser Trp Val Ser Arg Tyr Tyr Gln Leu 
        515                 520                 525             


Lys Pro Val Gly Thr Val Gly Met Thr Arg Arg Leu Gly Leu Met Lys 
    530                 535                 540                 


Gln 
545 


<210>  10
<211>  530
<212>  PRT
<213>  Norovirus

<400>  10

Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     


Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             


Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 


Glu Gln Lys Thr Arg Pro Phe Thr Leu Pro Asn Leu Pro Leu Ser Ser 
225                 230                 235                 240 


Leu Ser Asn Ser Arg Ala Pro Leu Pro Ile Ser Ser Met Gly Ile Ser 
                245                 250                 255     


Pro Asp Asn Val Gln Ser Val Gln Phe Gln Asn Gly Arg Cys Thr Leu 
            260                 265                 270         


Asp Gly Arg Leu Val Gly Thr Thr Pro Val Ser Leu Ser His Val Ala 
        275                 280                 285             


Lys Ile Arg Gly Thr Ser Asn Gly Thr Val Ile Asn Leu Thr Glu Leu 
    290                 295                 300                 


Asp Gly Thr Pro Phe His Pro Phe Glu Gly Pro Ala Pro Ile Gly Phe 
305                 310                 315                 320 


Pro Asp Leu Gly Gly Cys Asp Trp His Ile Asn Met Thr Gln Phe Gly 
                325                 330                 335     


His Ser Ser Gln Thr Gln Tyr Asp Val Asp Thr Thr Pro Asp Thr Phe 
            340                 345                 350         


Val Pro His Leu Gly Ser Ile Gln Ala Asn Gly Ile Gly Ser Gly Asn 
        355                 360                 365             


Tyr Val Gly Val Leu Ser Trp Ile Ser Pro Pro Ser His Pro Ser Gly 
    370                 375                 380                 


Ser Gln Val Asp Leu Trp Lys Ile Pro Asn Tyr Gly Ser Ser Ile Thr 
385                 390                 395                 400 


Glu Ala Thr His Leu Ala Pro Ser Val Tyr Pro Pro Gly Phe Gly Glu 
                405                 410                 415     


Val Leu Val Phe Phe Met Ser Lys Met Pro Gly Pro Gly Ala Tyr Asn 
            420                 425                 430         


Leu Pro Cys Leu Leu Pro Gln Glu Tyr Ile Ser His Leu Ala Ser Glu 
        435                 440                 445             


Gln Ala Pro Thr Val Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro 
    450                 455                 460                 


Asp Thr Gly Arg Asn Leu Gly Glu Phe Lys Ala Tyr Pro Asp Gly Phe 
465                 470                 475                 480 


Leu Thr Cys Val Pro Asn Gly Ala Ser Ser Gly Pro Gln Gln Leu Pro 
                485                 490                 495     


Ile Asn Gly Val Phe Val Phe Val Ser Trp Val Ser Arg Phe Tyr Gln 
            500                 505                 510         


Leu Lys Pro Val Gly Thr Ala Ser Ser Ala Arg Gly Arg Leu Gly Leu 
        515                 520                 525             


Arg Arg 
    530 


<210>  11
<211>  546
<212>  PRT
<213>  Norovirus

<400>  11

Met Met Met Ala Ser Lys Asp Ala Pro Gln Ser Ala Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Thr Ala Asp Pro Leu Pro 
            20                  25                  30          


Met Glu Pro Val Ala Gly Pro Thr Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Val Asn Asn Phe Val Gln Ser Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Leu 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Ser Ala Gly Lys Ile Ile Val Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Thr Ser Ser Ser Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Glu Pro Ile Glu Met 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Tyr His Thr Asn Asp Asn Gln 
                165                 170                 175     


Pro Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly 
            180                 185                 190         


Gly Gly Ser Gly Ser Ser Asp Ser Phe Val Val Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Ala Pro Ser Ser Asp Phe Ser Phe Leu Phe Leu Val Pro Pro Thr 
    210                 215                 220                 


Ile Glu Gln Lys Thr Arg Ala Phe Thr Val Pro Asn Ile Pro Leu Gln 
225                 230                 235                 240 


Thr Leu Ser Asn Ser Arg Phe Pro Ser Leu Ile Gln Gly Met Ile Leu 
                245                 250                 255     


Ser Pro Asp Ala Ser Gln Val Val Gln Phe Gln Asn Gly Arg Cys Leu 
            260                 265                 270         


Ile Asp Gly Gln Leu Leu Gly Thr Thr Pro Ala Thr Ser Gly Gln Leu 
        275                 280                 285             


Phe Arg Val Arg Gly Lys Ile Asn Gln Gly Ala Arg Thr Leu Asn Leu 
    290                 295                 300                 


Thr Glu Val Asp Gly Lys Pro Phe Met Ala Phe Asp Ser Pro Ala Pro 
305                 310                 315                 320 


Val Gly Phe Pro Asp Phe Gly Lys Cys Asp Trp His Met Arg Ile Ser 
                325                 330                 335     


Lys Thr Pro Asn Asn Thr Ser Ser Gly Asp Pro Met Arg Ser Val Ser 
            340                 345                 350         


Val Gln Thr Asn Val Gln Gly Phe Val Pro His Leu Gly Ser Ile Gln 
        355                 360                 365             


Phe Asp Glu Val Phe Asn His Pro Thr Gly Asp Tyr Ile Gly Thr Ile 
    370                 375                 380                 


Glu Trp Ile Ser Gln Pro Ser Thr Pro Pro Gly Thr Asp Ile Asn Leu 
385                 390                 395                 400 


Trp Glu Ile Pro Asp Tyr Gly Ser Ser Leu Ser Gln Ala Ala Asn Leu 
                405                 410                 415     


Ala Pro Pro Val Phe Pro Pro Gly Phe Gly Glu Ala Leu Val Tyr Phe 
            420                 425                 430         


Val Ser Ala Phe Pro Gly Pro Asn Asn Arg Ser Ala Pro Asn Asp Val 
        435                 440                 445             


Pro Cys Leu Leu Pro Gln Glu Tyr Ile Thr His Phe Val Ser Glu Gln 
    450                 455                 460                 


Ala Pro Thr Met Gly Asp Ala Ala Leu Leu His Tyr Val Asp Pro Asp 
465                 470                 475                 480 


Thr Asn Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Gly Gly Tyr Leu 
                485                 490                 495     


Thr Cys Val Pro Asn Gly Val Gly Ala Gly Pro Gln Gln Leu Pro Leu 
            500                 505                 510         


Asn Gly Val Phe Leu Phe Val Ser Trp Val Ser Arg Phe Tyr Gln Leu 
        515                 520                 525             


Lys Pro Val Gly Thr Ala Ser Thr Ala Arg Gly Arg Leu Gly Val Arg 
    530                 535                 540                 


Arg Ile 
545     


<210>  12
<211>  544
<212>  PRT
<213>  Norovirus

<400>  12

Met Met Met Ala Ser Lys Asp Ala Pro Thr Asn Met Asp Gly Thr Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Ala Asn Thr Ala Glu Pro Ile Ser 
            20                  25                  30          


Met Glu Pro Val Ala Gly Ala Ala Thr Ala Ala Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Met Asn Asn Tyr Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu 
                85                  90                  95      


Ala Gln Met Tyr Asn Gly Trp Val Gly Asn Met Lys Val Lys Val Leu 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Ile Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Ala Ser Gln Asn Ile Ser Ile Ala Gln Ala Thr Met 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Val Leu Glu Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Asn Thr 
                165                 170                 175     


Pro Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Ala Ser 
            180                 185                 190         


Gly Ser Ser Ser Gly Thr Asp Pro Phe Val Ile Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Ser Pro Asp Phe Ser Phe Leu Phe Leu Val Pro Pro Asn 
    210                 215                 220                 


Val Glu Gln Lys Thr Lys Pro Phe Ser Val Pro Asn Leu Pro Leu Asn 
225                 230                 235                 240 


Val Leu Ser Asn Ser Arg Val Pro Ser Leu Ile Lys Ser Met Met Val 
                245                 250                 255     


Ser Gln Asp His Gly Gln Met Val Gln Phe Gln Asn Gly Arg Val Thr 
            260                 265                 270         


Leu Asp Gly Gln Leu Gln Gly Thr Thr Pro Thr Ser Ala Ser Gln Leu 
        275                 280                 285             


Cys Lys Met Arg Gly Thr Val Tyr His Ala Ser Gly Gly Gln Gly Leu 
    290                 295                 300                 


Asn Leu Thr Glu Ile Asp Gly Thr Pro Tyr His Ala Phe Glu Ser Pro 
305                 310                 315                 320 


Ala Pro Ile Gly Phe Pro Asp Ile Gly Asp Ser Asp Trp His Ile Asn 
                325                 330                 335     


Ala Ser Pro Ala Thr Thr Phe Asp Ser Gly Glu Ser Ile Lys Arg Leu 
            340                 345                 350         


Asp Met Glu Gln Gly Ser Ser Phe Ala Pro His Leu Gly Thr Val His 
        355                 360                 365             


Tyr Thr Asn Ala Asp Tyr Pro Ala Asn Thr Asp Leu Ile Cys Ser Leu 
    370                 375                 380                 


Glu Trp Leu Ser Pro Pro Ser Gly Gly Thr Pro Asn Lys Val Asn Pro 
385                 390                 395                 400 


Trp Thr Ile Pro Arg Tyr Gly Ser Thr Leu Thr Glu Ala Ala Gln Leu 
                405                 410                 415     


Ala Pro Pro Ile Tyr Pro Pro Gly Phe Gly Glu Ala Ile Val Phe Phe 
            420                 425                 430         


Met Ser Asp Phe Pro Ile Ala Asn Gly Gln Asp Gly Leu Lys Val Pro 
        435                 440                 445             


Cys Thr Ile Pro Gln Glu Phe Val Thr His Phe Val Asn Glu Gln Ala 
    450                 455                 460                 


Pro Thr Arg Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr 
465                 470                 475                 480 


His Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Glu Gly Phe Met Thr 
                485                 490                 495     


Cys Val Pro Asn Ser Ser Gly Ser Gly Pro Gln Thr Leu Pro Ile Asn 
            500                 505                 510         


Gly Val Phe Thr Phe Val Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys 
        515                 520                 525             


Pro Val Gly Thr Thr Gly Pro Val Arg Arg Leu Gly Ile Arg Arg Ser 
    530                 535                 540                 


<210>  13
<211>  544
<212>  PRT
<213>  Norovirus

<400>  13

Met Met Met Ala Ser Lys Asp Ala Pro Thr Asn Met Asp Gly Thr Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Ala Asn Thr Ala Glu Pro Ile Ser 
            20                  25                  30          


Met Glu Pro Val Ala Gly Ala Ala Thr Ala Ala Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Met Asn Asn Tyr Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu 
                85                  90                  95      


Ala Gln Met Tyr Asn Gly Trp Val Gly Asn Met Lys Val Lys Val Leu 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Ile Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Ala Ser Gln Asn Ile Ser Ile Ala Gln Ala Thr Met 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Val Leu Glu Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Asn Ser 
                165                 170                 175     


Pro Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Ala Ser 
            180                 185                 190         


Gly Ser Ser Ser Gly Thr Asp Pro Phe Val Ile Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Ser Pro Asp Phe Ser Phe Leu Phe Leu Val Pro Pro Asn 
    210                 215                 220                 


Val Glu Gln Lys Thr Lys Pro Phe Ser Val Pro Asn Leu Pro Leu Asn 
225                 230                 235                 240 


Thr Leu Ser Asn Ser Arg Val Pro Ser Leu Ile Asn Ala Met Met Ile 
                245                 250                 255     


Ser Arg Asp His Gly Gln Met Val Gln Phe Gln Asn Gly Arg Val Thr 
            260                 265                 270         


Leu Asp Gly Gln Leu Gln Gly Thr Thr Pro Thr Ser Leu Ser Gln Leu 
        275                 280                 285             


Cys Lys Ile Arg Gly Lys Val Phe Leu Ala Ser Gly Gly Asn Gly Leu 
    290                 295                 300                 


Asn Leu Thr Glu Leu Asp Gly Ser Ala Tyr His Ala Phe Glu Ser Pro 
305                 310                 315                 320 


Ala Pro Ile Gly Phe Pro Asp Ile Gly Asp Cys Asp Trp His Met Asn 
                325                 330                 335     


Ala Thr Ala Thr Ser Asn Phe Thr Gly Ser Asn Asp Glu His Gln Ile 
            340                 345                 350         


Leu Val Lys Gln Glu Ser Thr Phe Ala Pro His Leu Gly His Val Gln 
        355                 360                 365             


Ala Asp His Leu Pro Glu Val Ala Asn Thr Asp Leu Met Val Ser Leu 
    370                 375                 380                 


Ser Trp Ile Ser Pro Val Ser Asp Gln His Arg Arg Asp Val Asp Pro 
385                 390                 395                 400 


Trp Val Ile Pro Arg Tyr Gly Ser Thr Leu Thr Glu Ala Ala Gln Leu 
                405                 410                 415     


Ala Pro Pro Ile Tyr Pro Pro Gly Phe Gly Glu Ala Ile Val Phe Phe 
            420                 425                 430         


Met Ser Asp Phe Pro Val Val Ser Gly Val Asn Gly Met Arg Ile Pro 
        435                 440                 445             


Cys Thr Leu Pro Gln Glu Tyr Val Ala His Phe Val Asn Glu Gln Ala 
    450                 455                 460                 


Pro Thr Arg Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr 
465                 470                 475                 480 


His Arg Asn Leu Gly Glu Phe Lys Ile Tyr Pro Glu Gly Phe Met Thr 
                485                 490                 495     


Cys Val Pro Asn Ser Ser Gly Thr Gly Pro Gln Thr Leu Pro Ile Asn 
            500                 505                 510         


Gly Val Phe Thr Phe Val Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys 
        515                 520                 525             


Pro Val Gly Thr Ala Gly Pro Ala Arg Arg Leu Gly Ile Arg Arg Ser 
    530                 535                 540                 


<210>  14
<211>  533
<212>  PRT
<213>  Norovirus

<400>  14

Met Met Met Ala Ser Lys Asp Ala Thr Pro Ser Ala Asp Gly Ala Thr 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Thr Ala Asp Pro Ile Pro 
            20                  25                  30          


Ile Asp Pro Val Ala Gly Ser Ser Thr Ala Leu Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Leu Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Val 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Val Ile Ile Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Gln Ser Arg Thr Leu Ser Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Val Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Tyr His Asn Asn Asp Thr Gln 
                165                 170                 175     


Pro Thr Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly 
            180                 185                 190         


Gly Ala Ser Gly Gly Thr Asp Ser Phe Val Val Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Gly Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr 
    210                 215                 220                 


Val Glu Gln Lys Thr Arg Pro Phe Thr Val Pro Asn Ile Pro Leu Lys 
225                 230                 235                 240 


Tyr Leu Ser Asn Ser Arg Ile Pro Asn Pro Ile Glu Gly Met Ser Leu 
                245                 250                 255     


Ser Pro Asp Gln Thr Gln Asn Val Gln Phe Gln Asn Gly Arg Cys Thr 
            260                 265                 270         


Ile Asp Gly Gln Pro Leu Gly Thr Thr Pro Val Ser Val Ser Gln Leu 
        275                 280                 285             


Cys Lys Phe Arg Gly Arg Ile Thr Ser Gly Gln Arg Val Leu Asn Leu 
    290                 295                 300                 


Thr Glu Leu Asp Gly Ser Pro Phe Met Ala Phe Ala Ala Pro Ala Pro 
305                 310                 315                 320 


Ala Gly Phe Pro Asp Leu Gly Ser Cys Asp Trp His Ile Glu Met Ser 
                325                 330                 335     


Lys Ile Pro Asn Ser Ser Thr Gln Asn Asn Pro Ile Val Val Asn Ser 
            340                 345                 350         


Val Lys Pro Asn Ser Gln Gln Phe Val Pro His Leu Ser Ser Ile Thr 
        355                 360                 365             


Leu Asp Asp Asn Val Ser Ser Gly Gly Asp Tyr Ile Gly Thr Ile Gln 
    370                 375                 380                 


Trp Thr Ser Pro Pro Ser Asp Ser Gly Gly Ala Asn Thr Asn Phe Trp 
385                 390                 395                 400 


Lys Ile Pro Asp Tyr Gly Ser Ser Leu Ala Glu Ala Ser Gln Leu Ala 
                405                 410                 415     


Pro Ala Val Tyr Pro Pro Gly Phe Asn Glu Val Ile Val Tyr Phe Met 
            420                 425                 430         


Ala Ser Ile Pro Gly Pro Asn Gln Ser Gly Ser Pro Asn Leu Val Pro 
        435                 440                 445             


Cys Leu Leu Pro Gln Glu Tyr Ile Thr His Phe Ile Ser Glu Gln Ala 
    450                 455                 460                 


Pro Ile Gln Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr 
465                 470                 475                 480 


Asn Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Gly Gly Tyr Leu Thr 
                485                 490                 495     


Cys Val Pro Asn Ser Ser Ser Thr Gly Pro Gln Gln Leu Pro Leu Asp 
            500                 505                 510         


Gly Val Phe Val Phe Ala Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys 
        515                 520                 525             


Pro Val Gly Thr Ala 
    530             


<210>  15
<211>  544
<212>  PRT
<213>  Norovirus

<400>  15

Met Met Met Ala Ser Lys Asp Ala Thr Pro Ser Ala Asp Gly Ala Thr 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Thr Ala Asp Pro Ile Pro 
            20                  25                  30          


Ile Asp Pro Val Ala Gly Ser Ser Thr Ala Leu Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Leu Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Val 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Val Ile Ile Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Gln Ser Arg Thr Leu Ser Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Val Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Tyr His Asn Asn Asp Thr Gln 
                165                 170                 175     


Pro Thr Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly 
            180                 185                 190         


Gly Ala Ser Gly Gly Thr Asp Ser Phe Val Val Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Gly Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr 
    210                 215                 220                 


Val Glu Gln Lys Thr Arg Pro Phe Thr Val Pro Asn Ile Pro Leu Lys 
225                 230                 235                 240 


Tyr Leu Ser Asn Ser Arg Ile Pro Asn Pro Ile Glu Gly Met Ser Leu 
                245                 250                 255     


Ser Pro Asp Gln Thr Gln Asn Val Gln Phe Gln Asn Gly Arg Cys Thr 
            260                 265                 270         


Ile Asp Gly Gln Pro Leu Gly Thr Thr Pro Val Ser Val Ser Gln Leu 
        275                 280                 285             


Cys Lys Phe Arg Gly Arg Ile Thr Ser Gly Gln Arg Val Leu Asn Leu 
    290                 295                 300                 


Thr Glu Leu Asp Gly Ser Pro Phe Met Gly Phe Gly Ala Pro Ala Pro 
305                 310                 315                 320 


Ala Gly Phe Pro Asp Leu Gly Ser Cys Asp Trp His Ile Glu Met Ser 
                325                 330                 335     


Lys Ile Pro Asn Ser Ser Thr Gln Asn Asn Pro Ile Val Thr Asn Ser 
            340                 345                 350         


Val Lys Pro Asn Ser Gln Gln Phe Val Pro His Leu Ser Ser Ile Thr 
        355                 360                 365             


Leu Asp Glu Asn Val Ser Ser Gly Gly Asp Tyr Ile Gly Thr Ile Gln 
    370                 375                 380                 


Trp Thr Ser Pro Pro Ser Asp Ser Gly Gly Ala Asn Thr Asn Phe Trp 
385                 390                 395                 400 


Lys Ile Pro Asp Tyr Gly Ser Ser Leu Ala Glu Ala Ser Gln Leu Ala 
                405                 410                 415     


Pro Ala Val Tyr Pro Pro Gly Phe Asn Glu Val Ile Val Tyr Phe Met 
            420                 425                 430         


Ala Ser Ile Pro Gly Pro Asn Gln Ser Gly Ser Pro Asn Leu Val Pro 
        435                 440                 445             


Cys Leu Leu Pro Gln Glu Tyr Ile Thr His Phe Ile Ser Glu Gln Ala 
    450                 455                 460                 


Pro Ile Gln Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr 
465                 470                 475                 480 


Asn Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Gly Gly Tyr Leu Thr 
                485                 490                 495     


Cys Val Pro Asn Ser Ser Ser Thr Gly Pro Gln Gln Leu Pro Leu Asp 
            500                 505                 510         


Gly Val Phe Val Phe Ala Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys 
        515                 520                 525             


Pro Val Gly Thr Ala Gly Pro Ala Arg Gly Arg Leu Gly Val Arg Arg 
    530                 535                 540                 


<210>  16
<211>  543
<212>  PRT
<213>  Norovirus

<400>  16

Met Met Met Ala Ser Lys Asp Ala Thr Pro Ser Ala Asp Gly Ala Asn 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Asn Ala Glu Pro Leu Pro 
            20                  25                  30          


Leu Asp Pro Val Ala Gly Ala Ser Thr Ala Leu Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Phe Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ala His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Ile 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Val Ile Ile Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Gln Ser Arg Thr Leu Ser Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Ile Ile Ala Asp Val Arg Thr Leu Glu Pro Ile Glu Ile 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Thr Leu Tyr His Thr Asn Asp Asn Gln 
                165                 170                 175     


Pro Thr Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Thr Asp Ala Phe Val Val Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Ser Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr 
    210                 215                 220                 


Val Glu Gln Lys Thr Arg Pro Phe Ser Val Pro Asn Ile Pro Leu Gln 
225                 230                 235                 240 


Leu Leu Ser Asn Ser Arg Val Pro Asn Leu Ile Gln Ser Met Val Pro 
                245                 250                 255     


Ser Pro Asp Gln Ala Gln Asn Val Gln Phe Gln Asn Gly Arg Cys Thr 
            260                 265                 270         


Thr Asp Gly Gln Leu Leu Gly Thr Thr Pro Val Ser Val Ser Gln Ile 
        275                 280                 285             


Leu Lys Phe Arg Gly Lys Val Ser Ala Gly Ser Lys Val Ile Asn Leu 
    290                 295                 300                 


Thr Glu Leu Asp Gly Ser Pro Phe Leu Ala Phe Glu Ala Pro Ala Pro 
305                 310                 315                 320 


Thr Gly Phe Pro Asp Leu Gly Thr Ser Asp Trp His Ile Glu Met Ser 
                325                 330                 335     


Leu Asn Ser Asn Ser Gln Ser Ser Gly Asn Pro Ile Leu Leu Arg Asp 
            340                 345                 350         


Ile Gln Pro Asn Ser Ser Asp Phe Val Pro His Leu Gly Ser Val Ala 
        355                 360                 365             


Val Thr Thr Ala Ile Asp Thr Ala Gly Asp Tyr Thr Gly Thr Ile Gln 
    370                 375                 380                 


Trp Thr Ser Gln Pro Ser Asn Val Thr Pro Val Pro Asp Val Asn Phe 
385                 390                 395                 400 


Trp Thr Ile Pro Gln Tyr Gly Ser Asn Leu Ala Glu Ala Ser Gln Leu 
                405                 410                 415     


Ala Pro Val Val Tyr Pro Pro Gly Phe Gly Glu Ala Ile Val Tyr Phe 
            420                 425                 430         


Met Ser Pro Ile Pro Gly Pro Asn Thr Ala His Lys Pro Asn Leu Val 
        435                 440                 445             


Pro Cys Leu Leu Pro Gln Glu Phe Val Thr His Phe Val Ser Glu Gln 
    450                 455                 460                 


Ala Pro Ser Met Gly Glu Ala Ala Leu Val His Tyr Val Asp Pro Asp 
465                 470                 475                 480 


Thr Asn Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Glu Gly Phe Ile 
                485                 490                 495     


Thr Cys Val Pro Asn Gly Thr Gly Pro Gln Gln Leu Pro Leu Asn Gly 
            500                 505                 510         


Val Phe Val Phe Ala Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro 
        515                 520                 525             


Val Gly Thr Ala Asn Ser Ala Arg Gly Arg Leu Gly Val Arg Arg 
    530                 535                 540             


<210>  17
<211>  541
<212>  PRT
<213>  Norovirus

<400>  17

Met Met Met Ala Ser Lys Asp Ala Thr Pro Ser Ala Asp Gly Ala Asn 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Asn Ala Glu Pro Leu Pro 
            20                  25                  30          


Leu Asp Pro Val Ala Gly Ala Ser Thr Ala Leu Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Phe Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ala His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Ile 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Val Ile Ile Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Gln Ser Arg Thr Leu Ser Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Glu Pro Leu Glu Ile 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Thr Leu Tyr His Asn Asn Asp Ser Gln 
                165                 170                 175     


Pro Thr Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Thr Asp Ala Phe Val Val Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr 
    210                 215                 220                 


Val Glu Gln Lys Thr Arg Pro Phe Ser Val Pro Asn Ile Pro Leu Gln 
225                 230                 235                 240 


Asn Leu Ser Asn Ser Arg Val Pro Ser Leu Ile Gln Ser Met Val Leu 
                245                 250                 255     


Ser Ser Asp His Ala Gln Thr Val Gln Phe Gln Asn Gly Arg Cys Thr 
            260                 265                 270         


Thr Asp Gly His Leu Leu Gly Thr Thr Pro Val Ser Ser Gly Gln Leu 
        275                 280                 285             


Met Lys Phe Arg Gly Lys Val Thr Pro Gly Ser Lys Val Leu Asn Leu 
    290                 295                 300                 


Thr Glu Leu Asp Gly Ser Pro Phe Leu Ala Phe Glu Pro Pro Ala Pro 
305                 310                 315                 320 


Ala Gly Phe Pro Asp Leu Gly Lys Cys Asp Trp His Ile Glu Met Ser 
                325                 330                 335     


Leu Tyr Gln Val Asn Asn Gln Asp Asn Pro Ile Val Leu Arg Ala Ile 
            340                 345                 350         


Glu Pro Asn Ser Ser Ser Phe Val Pro His Leu Gly Ser Val Ser Phe 
        355                 360                 365             


Asn Gln Asn Val Asp Ala Ala Gly Asp Tyr Val Cys Thr Ile Gln Tyr 
    370                 375                 380                 


Thr Ser Pro Pro Ser Asn Ser His Asp Ala Asp Val Asp Phe Trp Ser 
385                 390                 395                 400 


Ile Pro Asp Tyr Gly Ser Asn Leu Ala Glu Ala Ser Gln Leu Ala Pro 
                405                 410                 415     


Val Val Tyr Pro Pro Gly Phe Gly Glu Ala Ile Val Tyr Phe Met Ser 
            420                 425                 430         


Arg Val Pro Gly Trp Asn Arg Thr Asn Arg Leu Asn Leu Val Pro Cys 
        435                 440                 445             


Leu Leu Pro Gln Glu Phe Ile Gly His Phe Val Ser Glu Gln Ala Pro 
    450                 455                 460                 


Ala Ile Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr Asn 
465                 470                 475                 480 


Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Glu Gly Phe Ile Thr Cys 
                485                 490                 495     


Val Pro Asn Gly Thr Gly Pro Gln Gln Leu Pro Leu Asn Gly Val Phe 
            500                 505                 510         


Val Phe Ser Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val Gly 
        515                 520                 525             


Thr Ala Ser Ser Ala Arg Gly Arg Leu Gly Ile Arg Arg 
    530                 535                 540     


<210>  18
<211>  540
<212>  PRT
<213>  Norovirus

<400>  18

Met Met Met Ala Ser Lys Asp Val Pro Thr Ser Pro Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Thr Ala Asp Gln Ile Ser 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ala Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Phe Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ala His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Leu 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Ile Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Asp Ala Arg Ile Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Leu Ile Ala Asp Val Arg Thr Leu Glu Pro Val Glu Leu 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Tyr His Asn Ser Ser Gln Pro 
                165                 170                 175     


Gln Pro Thr Met Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Thr Asp Ala Phe Val Val Ala Gly Arg Val 
        195                 200                 205             


Leu Thr Cys Pro Ala Pro Asp Phe Ser Phe Leu Phe Leu Val Pro Pro 
    210                 215                 220                 


Ser Val Glu Gln Lys Thr Arg Val Phe Ser Val Pro Asn Ile Pro Leu 
225                 230                 235                 240 


Lys Asp Leu Ser Asn Ser Arg Val Pro Thr Leu Ile Gln Gly Met Phe 
                245                 250                 255     


Val Ser Pro Asp Val Asn Gln Ser Val Gln Phe Gln Asn Gly Arg Cys 
            260                 265                 270         


Gln Ile Asp Gly Gln Leu Gln Gly Thr Thr Pro Val Ser Leu Ser Gln 
        275                 280                 285             


Leu Cys Lys Ile Arg Gly Lys Thr Ser Ser Asn Thr Arg Val Leu Asn 
    290                 295                 300                 


Leu Ser Glu Val Asp Gly Thr Pro Phe Val Pro Leu Glu Ser Pro Ala 
305                 310                 315                 320 


Pro Val Gly Phe Pro Asp Ile Gly Gly Cys Asp Trp His Val Gly Phe 
                325                 330                 335     


Thr Phe Glu Ala Arg Asp Gln Gly Pro Ser Gln Asn Val Thr Phe Ala 
            340                 345                 350         


Thr Asn Asp Ser Ser Phe Val Pro Tyr Leu Gly Ser Ile Ser Pro His 
        355                 360                 365             


Asn Gly Asp Gly Phe His Ser Gly Asp Ile Ile Gly Ser Leu Asp Trp 
    370                 375                 380                 


Ile Ser Ala Pro Ser Asp Gly Ser Ala Leu Asp Val Trp Ser Ile Pro 
385                 390                 395                 400 


Lys Tyr Gly Ser Ser Leu Pro Asp Val Thr His Leu Ala Pro Ala Val 
                405                 410                 415     


Phe Pro Pro Gly Phe Gly Glu Val Ile Leu Tyr Phe His Ser Lys Phe 
            420                 425                 430         


Pro Gly Ser Gly Pro Thr Asp Lys Leu Arg Val Pro Cys Leu Met Pro 
        435                 440                 445             


Gln Glu Phe Ile Thr His Phe Cys Asp Glu Gln Ala Pro Ile Ala Gly 
    450                 455                 460                 


Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Ala Gly Arg Asn Leu 
465                 470                 475                 480 


Gly Glu Phe Lys Leu Tyr Pro Asp Gly Phe Met Thr Cys Val Pro Asn 
                485                 490                 495     


Ser Ile Ser Ser Gly Pro Gln Thr Leu Pro Ile Asn Gly Val Phe Val 
            500                 505                 510         


Phe Val Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val Gly Thr 
        515                 520                 525             


Ala Ser Met Ala Arg Arg Leu Gly Leu Arg Arg Ile 
    530                 535                 540 


<210>  19
<211>  539
<212>  PRT
<213>  Norovirus

<400>  19

Met Met Met Ala Ser Lys Asp Ala Pro Ser Asn Met Asp Gly Thr Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ala Glu Pro Leu Pro 
            20                  25                  30          


Leu Glu Pro Val Val Gly Ala Ala Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Leu Ile Asp Pro Trp Ile Met Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Glu Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Gln His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Ile Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Ala Ser Gln Asn Ile Ser Ile Gly Gln Ala Thr Met 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Val Leu Glu Pro Ile Glu Ile 
145                 150                 155                 160 


Pro Leu Asp Asp Val Arg Asn Val Leu Phe His Thr Asn Glu Ser Arg 
                165                 170                 175     


Pro Thr Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Ala Gly 
            180                 185                 190         


Gly Ala Ser Ser Gly Thr Asp Pro Phe Val Ile Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Ser 
    210                 215                 220                 


Val Glu Gln Lys Thr Arg Gln Leu Thr Val Pro Asn Ile Pro Leu Asn 
225                 230                 235                 240 


Asn Leu Ala Asn Ser Arg Val Pro Ala Met Ile Asn Lys Met Thr Val 
                245                 250                 255     


Ser Thr Asp Gln Ser Gln Val Val Gln Phe Gln Asn Gly Arg Cys Thr 
            260                 265                 270         


Leu Glu Gly Gln Leu Leu Gly Thr Thr Pro Val Ser Ala Ser Gln Val 
        275                 280                 285             


Ala Arg Ile Arg Gly Lys Val Phe Ser Thr Ala Ser Gly Lys Gly Leu 
    290                 295                 300                 


Asn Leu Thr Glu Leu Asp Gly Thr Pro Tyr His Ala Phe Glu Ser Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Phe Pro Asp Ile Gly Ala Cys Asp Trp His Val Ser 
                325                 330                 335     


Thr Phe Lys Val Asp Gln Asn Leu Ser Gly Asp Pro Met Ser Arg Leu 
            340                 345                 350         


Asp Ile Lys Gln Asn Ala Pro Phe Ala Pro His Leu Gly Ser Ile Glu 
        355                 360                 365             


Phe Thr Ser Asp Gln Glu Pro Thr Gly Asp Gln Leu Gly Thr Leu Ala 
    370                 375                 380                 


Trp Val Ser Pro Ser Thr Ser Gly Ala Arg Val Asp Pro Trp Lys Ile 
385                 390                 395                 400 


Pro Ser Tyr Gly Ser Thr Val Thr Glu Ser Thr His Leu Ala Pro Pro 
                405                 410                 415     


Ile Phe Pro Pro Gly Phe Gly Glu Ala Ile Val Tyr Phe Met Ser Asp 
            420                 425                 430         


Phe Pro Ile Val Ser Gly Asn Thr Ala Gln Val Pro Cys Thr Leu Pro 
        435                 440                 445             


Gln Glu Phe Val Ser His Phe Val Glu Gln Gln Ala Pro Ile Arg Gly 
    450                 455                 460                 


Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr His Arg Asn Leu 
465                 470                 475                 480 


Gly Glu Phe Lys Leu Tyr Pro Asp Gly Phe Ile Thr Cys Val Pro Asn 
                485                 490                 495     


Thr Gly Gly Gly Pro Gln Asn Leu Pro Ile Asn Gly Val Phe Val Phe 
            500                 505                 510         


Ser Ser Trp Val Ser Arg Tyr Tyr Gln Leu Lys Pro Val Gly Thr Ala 
        515                 520                 525             


Gly Pro Ala Arg Arg Leu Gly Val Arg Arg Val 
    530                 535                 


<210>  20
<211>  543
<212>  PRT
<213>  Norovirus

<400>  20

Met Met Met Ala Ser Lys Asp Ala Pro Thr Asn Met Asp Gly Thr Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Ala Asn Thr Ala Glu Pro Leu Pro 
            20                  25                  30          


Ile Lys Pro Val Ala Gly Ala Ala Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Met Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ala His Leu 
                85                  90                  95      


Ser Arg Met Tyr Asn Gly Trp Val Gly Asn Met Gln Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Ser Ala Gly Lys Ile Ile Val Cys Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Ser Ser Gln Ser Ile Ser Ile Ala Gln Ala Thr Met 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Val Leu Glu Pro Ile Asp Val 
145                 150                 155                 160 


Pro Leu Asp Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Asn Pro 
                165                 170                 175     


Gln Thr Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Ser Gly 
            180                 185                 190         


Gly Thr Ser Ser Gly Thr Asp Pro Phe Val Ile Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Thr Pro Asp Phe Ser Phe Leu Phe Leu Val Pro Pro Asp 
    210                 215                 220                 


Ile Glu Gln Arg Thr Lys Pro Phe Ser Val Pro Asn Ile Pro Met Asn 
225                 230                 235                 240 


Leu Met Ser Asn Ser Arg Val Ser Met Leu Ile Asp Gly Met Met Val 
                245                 250                 255     


Ser Asn Asp Gln Asn Gln Val Pro Gln Phe Gln Asn Gly Arg Val Thr 
            260                 265                 270         


Leu Asp Gly Gln Leu Gln Gly Thr Thr Thr Val Ser Ala Ala Cys Val 
        275                 280                 285             


Ala Arg Met Arg Gly Arg Ile Phe Asn Asn Asn Gly Asn Tyr Gly Val 
    290                 295                 300                 


Asn Leu Thr Glu Leu Asp Gly Asn Pro Tyr His Ala Phe Asp Ser Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Phe Pro Asp Phe Gly Asn Cys Asp Leu His Met Thr 
                325                 330                 335     


Phe Val Lys Ile Asn Pro Asn Glu Leu Ser Ser Gly Asp Pro Ser Gly 
            340                 345                 350         


Lys Val Val Ile Arg Ser Tyr Asp Ala Thr Phe Ala Pro His Leu Gly 
        355                 360                 365             


Thr Val Lys Leu Glu Asn Asp Asp Glu Leu Ala Arg Phe Val Gly Lys 
    370                 375                 380                 


Glu Val Val Leu Glu Leu Thr Trp Val Ser Asn Arg Glu Gly Ala Thr 
385                 390                 395                 400 


Leu Asn Leu Trp Ala Val Pro Asn Tyr Gly Ser Ser Leu Thr Gln Ala 
                405                 410                 415     


Ser Gln Leu Ala Pro Pro Ile Tyr Pro Pro Gly Phe Gly Glu Ala Ile 
            420                 425                 430         


Val Tyr Phe Thr Ser Thr Phe Pro Thr Val Ser Asn Pro Lys Val Pro 
        435                 440                 445             


Cys Thr Leu Pro Gln Glu Phe Val Ser His Phe Val Asn Glu Gln Ala 
    450                 455                 460                 


Pro Thr Arg Gly Asp Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr 
465                 470                 475                 480 


His Arg Asn Leu Gly Glu Phe Lys Met Tyr Pro Glu Gly Tyr Met Thr 
                485                 490                 495     


Cys Val Pro Asn Ala Gly Gly Gly Pro Gln Thr Leu Pro Ile Asn Gly 
            500                 505                 510         


Val Phe Val Phe Ile Ser Trp Val Ser Arg Tyr Tyr Gln Leu Lys Pro 
        515                 520                 525             


Val Gly Thr Ala Gly Ala Ala Arg Arg Leu Gly Leu Arg Arg Ser 
    530                 535                 540             


<210>  21
<211>  550
<212>  PRT
<213>  Norovirus

<400>  21

Met Met Met Ala Ser Lys Asp Ala Thr Ser Asn Met Asp Gly Thr Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Asn Asn Asn Thr Ser Glu Pro Ile 
            20                  25                  30          


Asn Met Glu Pro Val Ala Gly Ala Val Thr Ala Ala Ala Thr Ala Gly 
        35                  40                  45              


Gln Val Asn Met Ile Asp Pro Trp Ile Met Asn Asn Tyr Val Gln Ala 
    50                  55                  60                  


Pro Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile 
65                  70                  75                  80  


Leu Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ala His 
                85                  90                  95      


Leu Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Lys Val Arg Val 
            100                 105                 110         


Val Leu Ala Gly Asn Ala Phe Ser Ala Gly Lys Ile Ile Val Cys Cys 
        115                 120                 125             


Ile Pro Pro Gly Phe Ser Ala Pro Asn Ile Ser Ile Ala Gln Ala Thr 
    130                 135                 140                 


Met Phe Pro His Val Ile Ala Asp Val Arg Val Leu Glu Pro Ile Asp 
145                 150                 155                 160 


Ile Pro Leu Asp Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Asn 
                165                 170                 175     


Gly Asn Gln Thr Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg 
            180                 185                 190         


Ser Gly Gly Thr Ser Ser Gly Thr Asp Pro Phe Val Ile Ala Gly Arg 
        195                 200                 205             


Val Leu Thr Cys Pro Thr Pro Asp Phe Asn Phe Leu Phe Leu Val Pro 
    210                 215                 220                 


Pro Thr Val Glu Gln Lys Thr Lys Gln Phe Ser Val Pro Asn Leu Pro 
225                 230                 235                 240 


Leu Asn Val Met Ser Asn Ser Arg Val Pro Ser Leu Leu Asn Ala Met 
                245                 250                 255     


Val Val Ser Pro Asp Gln Ala Gln Val Val Gln Phe Gln Asn Gly Arg 
            260                 265                 270         


Cys Thr Leu Asp Gly Gln Met Leu Gly Thr Thr Thr Val Ser Ala Ser 
        275                 280                 285             


Cys Val Ala Arg Phe Arg Gly Lys Thr Phe Gln Ala Pro Asp Asn Arg 
    290                 295                 300                 


Leu Gly Ile Asn Leu Ala Glu Ile Ser Gly Glu Pro Tyr His Ala Phe 
305                 310                 315                 320 


Glu Ser Pro Ala Pro Leu Gly Phe Pro Asp Phe Gly Asp Gly Asp Trp 
                325                 330                 335     


His Val Thr Ala Thr Lys Val Thr Pro Ser Gln Leu Glu Ala Asn Asp 
            340                 345                 350         


Pro Val Val Met Gly Asn Val Gln Pro Tyr Asn Pro Gln Phe Ala Pro 
        355                 360                 365             


His Leu Gly Thr Leu Val Val Glu Asn Pro Thr Pro Asp Asn Val Thr 
    370                 375                 380                 


Thr Gly Thr Asp Leu Leu Phe Asn Ile Thr Trp Leu Ser Asn Arg Ala 
385                 390                 395                 400 


Asn Asn Arg Phe Asn Pro Trp Val Ile Pro Asn Tyr Gly Ser Thr Leu 
                405                 410                 415     


Thr Glu Ala Ala Gln Leu Ala Pro Ser Ile Phe Pro Pro Gly Phe Gly 
            420                 425                 430         


Glu Thr Ile Val Tyr Phe Asn Ser Thr Phe Pro Ala Val Gly Ala Thr 
        435                 440                 445             


Thr His Ala Ala Ile Pro Cys Leu Leu Pro Gln Glu Phe Val Ala His 
    450                 455                 460                 


Phe Val Asn Glu Gln Ala Pro Ile Arg Gly Glu Ala Ala Leu Leu His 
465                 470                 475                 480 


Tyr Ile Asp Pro Asp Thr His Arg Asn Leu Gly Glu Phe Lys Ile Tyr 
                485                 490                 495     


Pro Glu Gly Phe Val Thr Cys Val Pro Asn Val Gly Gly Thr Gly Pro 
            500                 505                 510         


Gln Ser Leu Pro Thr Asn Gly Ile Phe Val Phe Val Ser Trp Val Ser 
        515                 520                 525             


Arg Tyr Tyr Gln Leu Lys Pro Val Gly Thr Ala Gly Gln Ala Arg Arg 
    530                 535                 540                 


Leu Gly Phe Arg Arg Val 
545                 550 


<210>  22
<211>  538
<212>  PRT
<213>  Norovirus

<400>  22

Met Lys Met Ala Ser Asn Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Met Pro 
65                  70                  75                  80  


Leu Ser Pro Glu Leu Asn Pro Tyr Leu Ser His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Ile Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Asp Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ala Asn Asp Ser Thr Leu 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Thr Val Pro Ile Leu Thr Val Asp Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Thr Pro Leu Glu Lys Leu His Thr Gly Pro Asn Asn Ser 
                245                 250                 255     


Ile Val Val Gln Pro Gln Asn Gly Arg Cys Thr Ile Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Thr Val Asn Ile Cys Asn Phe Arg Gly 
        275                 280                 285             


Ser Thr Thr Arg Ala Gly Gln Ser His Ala Tyr Thr Met Asn Leu Val 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Val Gly Met Leu Ser Gln 
                325                 330                 335     


Thr Thr Arg Glu Asn Ser Ser Thr Arg Ala His Lys Ala Thr Val Ser 
            340                 345                 350         


Thr Gly Asp Ala His Phe Thr Pro Lys Ser Gly Ser Val Leu Phe Thr 
        355                 360                 365             


Thr Asp Thr Asp Asp Leu Gln Asn Gly Gln Asn Thr Arg Phe Thr Pro 
    370                 375                 380                 


Val Gly Val Ala Gln Asp Gly Glu Pro His Gln Asn Glu Pro Gln Gln 
385                 390                 395                 400 


Trp Arg Leu Pro Asn Tyr Ser Gly Thr Pro Gly His Asn Val His Leu 
                405                 410                 415     


Ala Pro Pro Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu Phe Phe 
            420                 425                 430         


Arg Ser Thr Met Pro Gly Cys Gly Gly Tyr Pro Asn Met Asp Leu Asp 
        435                 440                 445             


Cys Leu Leu Pro Gln Glu Trp Val Arg His Phe Tyr Gln Glu Ala Ala 
    450                 455                 460                 


Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro Asp Thr 
465                 470                 475                 480 


Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ala Gly Tyr Ile Thr 
                485                 490                 495     


Val Ser His Thr Gly Pro Tyr Asp Leu Val Ile Pro Pro Asn Gly Tyr 
            500                 505                 510         


Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ala Leu Ala Pro Met 
        515                 520                 525             


Gly Thr Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535             


<210>  23
<211>  543
<212>  PRT
<213>  Norovirus

<400>  23

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Gly Ala Ile Ala Ala Pro Leu Thr Gly Gln Thr Asn Phe Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Tyr Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Phe Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Ile Asp Val Gln Val Ile Met Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Ile Asp Asn Ile Ser Pro Pro Gln Ile Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Asn Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Ser Phe Phe His Tyr Ser Gln Asn Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Leu Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Ala 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Lys Pro Ser Ala 
        195                 200                 205             


Asp Phe Glu Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Thr Ile Pro Ile Leu Thr Ile Gly Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Ala Ile Asp Met Leu His Thr Ser Pro Thr Asp Asn 
                245                 250                 255     


Phe Ile Val Gln Pro Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Val Thr Ser Asn Ile Cys Ala Phe Arg Gly 
        275                 280                 285             


Ser Ile Ser Gly His Glu Asn Asn Gly Asp Gln His Gln Trp His Phe 
    290                 295                 300                 


Ser Ile Thr Asn Pro Asn Gly Thr Pro Phe Asp Pro Thr Glu Asp Val 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Lys Gly Gln Leu Tyr Gly Val 
                325                 330                 335     


Ile Ser Gln Arg Asn Arg Glu Gly Ser Pro Gly Asn Gly Asn Gln Lys 
            340                 345                 350         


Ala Asn Arg Ser His Glu Gly Val Ile Ser Thr Val Ala Pro Arg Phe 
        355                 360                 365             


Thr Pro Lys Leu Gly Ser Val Met Ile Gly Thr Trp Thr Thr Asp Asp 
    370                 375                 380                 


Ile Gln Asp Gln Pro Ser Arg Phe Thr Pro Val Gly Leu Asn Asp Asp 
385                 390                 395                 400 


Asp Asn Tyr Lys Gln Trp Glu Leu Pro Asn Tyr Ser Gly Ala Leu Thr 
                405                 410                 415     


Leu Asn Met Gly Leu Ala Pro Ser Val Phe Pro Thr Tyr Pro Gly Glu 
            420                 425                 430         


Gln Leu Leu Phe Phe Arg Ser Tyr Ile Pro Met Lys Gly Gly Tyr Gly 
        435                 440                 445             


Ser Pro Tyr Ile Asp Cys Leu Ile Pro Gln Glu Trp Ile Ser His Phe 
    450                 455                 460                 


Tyr Gln Glu Ser Ala Pro Ser Gln Thr Asp Val Ala Leu Ile Arg Tyr 
465                 470                 475                 480 


Val Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Arg 
                485                 490                 495     


Gln Gly Tyr Ile Thr Val Ala Lys Thr Gly Asp Ser Pro Ile Asn Val 
            500                 505                 510         


Pro Ala Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Ser Gln Phe Tyr 
        515                 520                 525             


Ser Leu Ala Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Ile Gln 
    530                 535                 540             


<210>  24
<211>  555
<212>  PRT
<213>  Norovirus

<400>  24

Met Arg Met Ala Ser Ser Asp Ala Pro Val Ser Gly Thr Asp Gly Ala 
1               5                   10                  15      


Ala Gly Leu Val Pro Glu Ser Gln Gln Glu Val Leu Pro Leu Glu Pro 
            20                  25                  30          


Val Ala Gly Val Gln Leu Ala Ala Pro Val Ala Gly Gln Ser Asn Ile 
        35                  40                  45              


Ile Asp Pro Trp Ile Arg Met Asn Phe Val Gln Ala Pro Ala Gly Glu 
    50                  55                  60                  


Phe Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Val Leu Ile Asp Leu 
65                  70                  75                  80  


Glu Leu Gly Pro Glu Leu Asn Pro Tyr Leu Asn His Leu Ala Arg Met 
                85                  90                  95      


Tyr Asn Gly Tyr Val Gly Gly Met Glu Val Glu Val Val Leu Ala Gly 
            100                 105                 110         


Asn Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Val Pro Pro Ser 
        115                 120                 125             


Phe Pro Thr His Gly Ile Ser Ala Ala Gln Ala Thr Met Leu Pro His 
    130                 135                 140                 


Val Ile Val Asp Val Arg Gln Leu Glu Pro Val Arg Leu Pro Leu Pro 
145                 150                 155                 160 


Asp Val Arg Asn Val Met Phe His Phe Cys Gln Glu Asn Lys Glu Pro 
                165                 170                 175     


Arg Met Arg Ile Val Ala Ile Leu Tyr Thr Pro Leu Arg Ala Asn Gly 
            180                 185                 190         


Ala Gly Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro 
        195                 200                 205             


Ser Pro Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Ser Val Glu Ser 
    210                 215                 220                 


Lys Leu Lys Gln Phe Thr Leu Pro Asn Leu Gln Pro Asn Glu Met Thr 
225                 230                 235                 240 


Asn Ser Arg Phe Pro Thr Gly Ile Thr Gln Leu Tyr Thr Ser Pro Asn 
                245                 250                 255     


Thr Asn Leu Val Val Gln Phe Gln Asn Gly Arg Cys Leu Leu Asp Gly 
            260                 265                 270         


Thr Leu Leu Gly Thr Thr Pro Val Arg Ala Ala Asp Ile Cys Ser Phe 
        275                 280                 285             


Arg Gly Val Thr Ser Thr Glu Val Asp Ala Thr Asp Ser Pro Arg Val 
    290                 295                 300                 


Ala Gly Ser His Arg Ile Met Val Gln Leu Lys Glu Pro Asp Gly Glu 
305                 310                 315                 320 


Glu Phe Ser Pro Thr Gly Pro Asn Pro Ala Pro Val Gly Thr Pro Asp 
                325                 330                 335     


Phe Gln Ala Ala Ile Phe Gly Thr Leu Ser Gln Arg Asn Thr Gly Gly 
            340                 345                 350         


Thr Gly Gln Asn Ser Asn Arg Ala His Phe Ala Tyr Phe Tyr Thr Arg 
        355                 360                 365             


Asn Pro Thr Phe Ala Pro Gly Ile Gly Thr Val Val Phe Ser Phe Asp 
    370                 375                 380                 


Thr Thr Asp Phe Gln Asn Arg Gln Pro Thr Lys Phe Ser Pro Ser Gly 
385                 390                 395                 400 


Val Phe Asp Asp Asp Ser Ser Glu Pro Phe Asn Gln Phe Ser Leu Pro 
                405                 410                 415     


Tyr Tyr Asn Gly Ser Leu Gly Ala Val Asp Ala Gly Lys Leu Ala Pro 
            420                 425                 430         


Pro Val Ala Pro Asn Tyr Pro Gly Glu Gln Ile Leu Tyr Phe Arg Gly 
        435                 440                 445             


Asn Ile Pro Phe Lys Gly Gly Tyr Gly Glu Gly Glu Ile Asp Ser Leu 
    450                 455                 460                 


Leu Pro Gln Glu Trp Ile Thr His Phe Tyr Ala Glu Gln Ala Pro Thr 
465                 470                 475                 480 


Gln Gly Asp Ala Ala Leu Leu Arg Tyr Tyr Asn Pro Asp Thr Gly Arg 
                485                 490                 495     


Val Leu Phe Glu Cys Lys Leu His Arg Glu Gly Phe Ile Thr Ile Asn 
            500                 505                 510         


Tyr Thr Gly Ser Asn Ala Leu Ala Val Pro Val Asn Gly Val Phe Arg 
        515                 520                 525             


Phe Glu Gly Trp Val Asn Lys Phe Tyr Thr Leu Thr Pro Met Gly Asn 
    530                 535                 540                 


Gly Asn Gly Arg Arg Gly Arg Arg Arg Glu Leu 
545                 550                 555 


<210>  25
<211>  535
<212>  PRT
<213>  Norovirus

<400>  25

Met Lys Met Ala Ser Asn Asp Ala Asn Pro Ser Ser Asp Gly Ser Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Ile Ser Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Val Leu Leu Asn Leu Pro 
65                  70                  75                  80  


Leu Ser Pro Asp Ile Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Glu Val Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Pro Glu Asn Leu Ser Pro Ser Gln Ile Thr Met Leu Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Arg Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Ser Arg Glu Asn Asp Ser Thr Leu 
                165                 170                 175     


Arg Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Lys Ser 
    210                 215                 220                 


Lys Pro Phe Thr Ile Pro Met Leu Thr Ile Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ala Pro Leu Glu Leu Met Thr Thr Gly Pro Ser His Asp 
                245                 250                 255     


Ile Val Val Gln Pro Gln Asn Gly Arg Cys Thr Ile Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Ser Leu Arg Gly 
        275                 280                 285             


Val Pro Thr Lys Arg Thr Asn Gly Asn Asp Asn Cys Phe Val Gln Leu 
    290                 295                 300                 


Glu Asn Pro Asn Gly Ser Ala Tyr Asp Pro Thr Glu Asp Ile Pro Ala 
305                 310                 315                 320 


Val Leu Gly Ser Pro Asp Phe Val Gly Glu Leu Tyr Gly Thr Ile Thr 
                325                 330                 335     


Gln Arg Ser Ser Asp Asn Ser Thr Arg Ala His Pro Phe Thr Leu Asn 
            340                 345                 350         


Thr Gly Ser Pro Arg Tyr Thr Pro Lys Ile Gly Ser Val Asp Ile Arg 
        355                 360                 365             


Val Thr Asp Val Ser Asp Leu Gln Asp His Asp Pro Val Lys Leu Thr 
    370                 375                 380                 


Pro Val Gly Leu Ser Gly Asp Arg Gly Ser Ile His Gln Trp Gln Leu 
385                 390                 395                 400 


Pro Asn Tyr Ser Gly Val Ala Thr His Asn Met His Leu Ala Pro Ser 
                405                 410                 415     


Val Ala Pro Leu Phe Pro Gly Glu Gln Ile Leu Phe Phe Arg Ser Thr 
            420                 425                 430         


Val Pro Gly Cys Gly Gly Tyr Pro Asn Ser Asn Ile Asp Cys Leu Ile 
        435                 440                 445             


Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu Gly Ala Pro Ala Arg 
    450                 455                 460                 


Thr Asp Val Ala Leu Leu Arg Phe Ile Asn Pro Asp Thr Gly Arg Val 
465                 470                 475                 480 


Leu Phe Glu Cys Lys Leu His Lys His Gly Phe Ile Thr Val Ala Tyr 
                485                 490                 495     


Ser Gly Asn His Asp Leu Val Met Pro Pro Asn Gly Tyr Phe Arg Phe 
            500                 505                 510         


Glu Ser Trp Val Asn Gln Phe His Thr Leu Ala Pro Met Gly Thr Gly 
        515                 520                 525             


Ser Gly Arg Arg Arg Ile Gln 
    530                 535 


<210>  26
<211>  555
<212>  PRT
<213>  Norovirus

<400>  26

Met Lys Met Ala Ser Lys Asp Ala Ser Pro Ser Thr Asp Gly Thr Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Ser Gln Gln Glu Val Leu Ala Leu Gln Pro Val 
            20                  25                  30          


Ala Gly Ala Gln Ile Ala Ala Pro Val Ala Gly Gln Phe Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Tyr Gln Asn Phe Val Gln Ala Pro Glu Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Thr Gly Glu Ile Leu Met Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Gln Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Ala Tyr Ala Gly Gly Phe Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Val Cys Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Leu Gln Asn Ile Ser Ala Ala Gln Ala Thr Gln Leu Pro His Val 
    130                 135                 140                 


Val Val Asp Val Arg Gln Leu Glu Pro Val Val Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Ala Gly Phe Tyr His Tyr Asn Gln Val Glu Glu Ser Arg Met 
                165                 170                 175     


Arg Leu Val Ala Ile Leu Tyr Thr Pro Leu Arg Thr Asn Ser Ala Gly 
            180                 185                 190         


Asp Asp Ala Phe Thr Val Ser Cys Arg Ile Leu Thr Arg Pro Ala Pro 
        195                 200                 205             


Asp Phe Ser Phe Phe Phe Leu Ile Pro Pro Thr Ile Glu Ser Lys Thr 
    210                 215                 220                 


Thr Pro Phe Thr Leu Pro Arg Leu Pro Ile Ser Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Leu Val Ile Lys Gly Met Val Val Asp Pro Asn Leu Pro 
                245                 250                 255     


Leu Gln Ala Asn Phe Gln Asn Gly Arg Ile Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Leu Pro Thr Ser Thr Ser Ile Gly Arg Ile Ser Gly 
        275                 280                 285             


Thr His Met Ser Ser Thr Pro Ser Arg Ile Ile Gln His Glu Asp Ser 
    290                 295                 300                 


Gly Asp Ser Thr Gln Pro Arg Val Phe Asn Pro Val Trp Met Asp Leu 
305                 310                 315                 320 


Thr Glu Asn Asn Trp Thr Glu Phe Gln Pro Phe Asn Asp Gln Pro Ala 
                325                 330                 335     


Pro Leu Gly Cys Pro Asp Phe Lys Ala Lys Ile Leu Gly Thr Leu Ile 
            340                 345                 350         


Arg Gln Pro Asn Asn Gly Ser Tyr Tyr Phe Asp Ala Tyr Leu Asp Thr 
        355                 360                 365             


Arg Gln His Gly Thr Phe Ala Pro Tyr Thr Gly His Ala Ala Val His 
    370                 375                 380                 


Ser Asp Gln Gln Ala Gly His Leu Ala Gln Gly Tyr Lys Ile Gln Phe 
385                 390                 395                 400 


Ser Pro Thr Gly Ile Glu Ser Asp Gln Asn Thr Asp Leu Asn Gln Leu 
                405                 410                 415     


Pro Asp Tyr Gly Gly Ala Met Thr Val Ser Lys Gly Leu Ala Pro Ala 
            420                 425                 430         


Ala Ala Pro Asp Phe Pro Gly Glu Met Ile Leu Tyr Phe Val Ser Asp 
        435                 440                 445             


Met Pro Val Arg Asn Pro Asn Gly Glu Arg Arg Asp Thr Glu Ile Leu 
    450                 455                 460                 


Cys Leu Leu Pro Gln Glu Met Val Thr His Phe Tyr Glu Gln Gln Ala 
465                 470                 475                 480 


Pro Ser Gln Gly Asp Val Ala Leu Val Arg Tyr Ile Asn Ala Glu Thr 
                485                 490                 495     


Gly Arg Val Met Phe Glu Gly Lys Leu His Arg Asn Gly Phe Phe Thr 
            500                 505                 510         


Val Ser Ala Thr Ala Arg Thr Leu Ile Val Pro Asp Gly Tyr Phe Arg 
        515                 520                 525             


Phe Asp Ser Trp Val Asn Arg Phe Tyr Thr Leu Ser Pro Met Gly Thr 
    530                 535                 540                 


Gly Asn Gly Arg Arg Arg Ala Arg Met Leu Glu 
545                 550                 555 


<210>  27
<211>  535
<212>  PRT
<213>  Norovirus

<400>  27

Met Lys Met Ala Ser Asn Asp Val Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Ser Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Met Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Phe Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Ile Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Leu Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Pro Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Gly Glu Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Glu Leu Tyr Thr Ser Pro Asn Glu Gly 
                245                 250                 255     


Val Val Val Gln Pro Gln Asn Gly Arg Ser Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Val Pro Ser Asn Ile Cys Ala Leu Arg Gly 
        275                 280                 285             


Arg Ile Asn Ala Gln Val Pro Asp Asp His His Gln Trp Asn Leu Gln 
    290                 295                 300                 


Val Thr Asn Ala Asn Gly Thr Ser Phe Asp Pro Thr Glu Asp Val Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Thr Pro Asp Phe Leu Ala Asn Ile Tyr Gly Val Thr 
                325                 330                 335     


Ser Gln Arg Asn Pro Asp Asn Thr Cys Arg Ala His Asp Gly Val Leu 
            340                 345                 350         


Ala Thr Trp Ser Pro Lys Phe Thr Pro Lys Leu Gly Ser Val Val Leu 
        355                 360                 365             


Gly Thr Trp Glu Glu Ser Asp Leu Asp Leu Asn Gln Pro Thr Arg Phe 
    370                 375                 380                 


Thr Pro Val Gly Leu Tyr Asp Thr Asn His Phe Asp Gln Trp Ile Leu 
385                 390                 395                 400 


Pro Asn Tyr Ser Gly Arg Leu Thr Leu Asn Met Asn Leu Ala Pro Ser 
                405                 410                 415     


Val Ala Pro Leu Phe Pro Gly Glu Gln Ile Leu Phe Phe Arg Ser His 
            420                 425                 430         


Ile Pro Leu Lys Gly Gly Thr Ser Asn Gly Ala Ile Asp Cys Leu Leu 
        435                 440                 445             


Pro Gln Glu Trp Ile Gln His Phe Tyr Gln Glu Ser Ala Pro Ser Pro 
    450                 455                 460                 


Thr Asp Val Ala Leu Ile Arg Tyr Thr Asn Pro Asp Thr Gly Arg Val 
465                 470                 475                 480 


Leu Phe Glu Ala Lys Leu His Arg Gln Gly Phe Ile Thr Val Ala Asn 
                485                 490                 495     


Ser Gly Ser Arg Pro Ile Val Val Pro Pro Asn Gly Tyr Phe Arg Phe 
            500                 505                 510         


Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro Met Gly Thr Gly 
        515                 520                 525             


Asn Gly Arg Arg Arg Val Gln 
    530                 535 


<210>  28
<211>  542
<212>  PRT
<213>  Norovirus

<400>  28

Met Lys Met Ala Ser Ile Asp Ala Ala Pro Ser Thr Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ser Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Leu Ala Ala Pro Val Thr Gly Gln Thr Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Ala Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Met Glu Val Gln Val Met Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Val Glu Asn Leu Ser Pro Gln Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Lys Asp Asp Pro Lys Met 
                165                 170                 175     


Arg Ile Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Thr Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Leu Gly Glu Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Ser Ile Asp Gln Met Tyr Thr Ser Pro Asn Glu Val 
                245                 250                 255     


Ile Ser Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Gln Val Ser Gly Ile Cys Ala Phe Lys Gly 
        275                 280                 285             


Glu Val Thr Ala His Leu His Asp Asn Asp His Leu Tyr Asn Val Thr 
    290                 295                 300                 


Ile Thr Asn Leu Asn Gly Ser Pro Phe Asp Pro Ser Glu Asp Ile Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Val Pro Asp Phe Gln Gly Arg Val Phe Gly Val Ile 
                325                 330                 335     


Ser Gln Arg Asp Lys His Asn Ser Pro Gly His Asn Glu Pro Ala Asn 
            340                 345                 350         


Arg Gly His Asp Ala Val Val Pro Thr Tyr Thr Ser Gln Tyr Thr Pro 
        355                 360                 365             


Lys Leu Gly Gln Ile Gln Ile Gly Thr Trp Gln Thr Asp Asp Leu Thr 
    370                 375                 380                 


Val Asn Gln Pro Val Lys Phe Thr Pro Val Gly Leu Asn Asp Thr Glu 
385                 390                 395                 400 


His Phe Asn Gln Trp Val Val Pro Arg Tyr Ala Gly Ala Leu Asn Leu 
                405                 410                 415     


Asn Thr Asn Leu Ala Pro Ser Val Ala Pro Val Phe Pro Gly Glu Arg 
            420                 425                 430         


Leu Leu Phe Phe Arg Ser Tyr Ile Pro Leu Lys Gly Gly Tyr Gly Asn 
        435                 440                 445             


Pro Ala Ile Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ser Met Ser Glu Val Ala Leu Val Arg Tyr Ile 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Ala Leu Phe Glu Ala Lys Leu His Arg Ala 
                485                 490                 495     


Gly Phe Met Thr Val Ser Ser Asn Thr Ser Ala Pro Val Val Val Pro 
            500                 505                 510         


Ala Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser 
        515                 520                 525             


Leu Ala Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Val Gln 
    530                 535                 540         


<210>  29
<211>  542
<212>  PRT
<213>  Norovirus

<400>  29

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Gly Ala Ile Ala Ala Pro Leu Thr Gly Gln Thr Asn Phe Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Gly Asn Tyr Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Phe Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Ile Asp Val Gln Val Ile Met Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Val Glu Asn Ile Ser Pro Pro Gln Ile Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Leu Glu Pro Ile Asn Ile Pro Val Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Asp Arg Asp Ser Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Thr 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Lys Pro Ser Ala 
        195                 200                 205             


Asp Phe Glu Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Ile Pro Ile Leu Thr Ile Gly Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Leu Pro Ile Asp Met Leu Tyr Thr Ser Pro Thr Glu Asn 
                245                 250                 255     


Leu Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Glu Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Val Thr Pro Ser Ile Cys Ser Leu Arg Gly 
        275                 280                 285             


Ala Ile Thr Gly His Glu Gly Asn Asp Asp Asp His Lys Trp His Met 
    290                 295                 300                 


Thr Val Thr Ser Pro Asn Gly Ala Ala Phe Asp Pro Thr Glu Asp Val 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Thr Gly Asp Ile Tyr Gly Val 
                325                 330                 335     


Leu Ser Gln Arg Asp Arg Asn Ile Asn Pro Gly Gln Thr Ala Pro Ala 
            340                 345                 350         


Asn Arg Ala His Glu Ala Val Val Ser Thr Arg Ser Asn Lys Phe Thr 
        355                 360                 365             


Pro Lys Leu Gly Ser Val Met Ile Ala Thr Trp Glu Thr Thr Asp Val 
    370                 375                 380                 


Leu Gln Gln Pro Thr Lys Phe Thr Pro Val Gly Leu Glu Ser Pro Asn 
385                 390                 395                 400 


His Tyr Asn Gln Trp Gln Leu Pro Asn Tyr Ser Gly Ala Leu Thr Leu 
                405                 410                 415     


Asn Met Gly Leu Ala Pro Ser Val Phe Pro Thr Tyr Pro Gly Glu Gln 
            420                 425                 430         


Ile Leu Phe Phe Arg Ser Phe Ile Pro Leu Lys Gly Gly Tyr Gly Asn 
        435                 440                 445             


Ser Ala Ile Asp Cys Leu Val Pro Gln Glu Trp Ile Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ser Ala Pro Ser Gln Thr Asp Val Ala Leu Ile Arg Tyr Val 
465                 470                 475                 480 


Asn Pro Glu Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Arg Gln 
                485                 490                 495     


Gly Phe Ile Thr Val Ala Lys Thr Gly Asp Ser Pro Ile Asn Val Pro 
            500                 505                 510         


Ala Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Pro Phe Tyr Ser 
        515                 520                 525             


Leu Ala Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Asn Gln 
    530                 535                 540         


<210>  30
<211>  548
<212>  PRT
<213>  Norovirus

<400>  30

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Asn Glu Ala Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Ile Ala Ala Pro Leu Thr Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Met Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Ile Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Ile Pro Pro Asn Phe 
        115                 120                 125             


Pro Ile Asp Asn Leu Ser Ala Ala Gln Ile Thr Met Cys Pro His Val 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Asn Leu Pro Met Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gly Ser Asp Ser Arg Leu 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Ser Phe Asn Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Ser Glu Met Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Ser Leu His Thr Ser Pro Thr Glu Asn 
                245                 250                 255     


Ile Val Val Gln Cys Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Met Gly Thr Thr Gln Leu Leu Pro Ser Gln Ile Cys Ala Phe Arg Gly 
        275                 280                 285             


Val Leu Thr Arg Ser Thr Ser Arg Ala Ser Asp Gln Ala Asp Thr Ala 
    290                 295                 300                 


Thr Pro Arg Leu Phe Asn Tyr Tyr Trp His Ile Gln Leu Ala Asn Leu 
305                 310                 315                 320 


Asn Gly Thr Pro Tyr Asp Pro Ala Glu Asp Ile Pro Gly Pro Leu Gly 
                325                 330                 335     


Thr Pro Asp Phe Arg Gly Lys Val Phe Gly Val Ala Cys Gln Arg Asn 
            340                 345                 350         


Pro Asp Cys Thr Thr Arg Ala His Glu Ala Lys Val Asp Thr Thr Ala 
        355                 360                 365             


Gly Arg Phe Thr Pro Lys Leu Gly Ser Leu Glu Ile Ser Thr Glu Ser 
    370                 375                 380                 


Gly Asp Phe Asp Gln Asn Gln Pro Thr Arg Phe Thr Pro Val Gly Ile 
385                 390                 395                 400 


Gly Val Asp His Glu Ala Asp Phe Gln Gln Trp Ser Leu Pro Asp Tyr 
                405                 410                 415     


Ser Gly Gln Phe Thr His Asn Met Asn Leu Ala Pro Ala Val Ala Pro 
            420                 425                 430         


Asn Phe Pro Gly Glu Gln Leu Leu Phe Phe Arg Ser Gln Leu Pro Ser 
        435                 440                 445             


Ser Gly Gly Arg Ser Asn Gly Ile Leu Asp Cys Leu Val Pro Gln Glu 
    450                 455                 460                 


Trp Val Gln His Phe Tyr Gln Glu Ser Ala Pro Ala Gln Thr Gln Val 
465                 470                 475                 480 


Ala Leu Val Arg Tyr Val Asn Pro Asp Thr Gly Arg Val Leu Phe Glu 
                485                 490                 495     


Ala Lys Leu His Lys Leu Gly Phe Met Thr Ile Ala Lys Asn Gly Asp 
            500                 505                 510         


Ser Pro Ile Thr Val Pro Pro Asn Gly Tyr Phe Arg Phe Glu Ser Trp 
        515                 520                 525             


Val Asn Pro Phe Tyr Thr Leu Ala Pro Met Gly Thr Gly Asn Gly Arg 
    530                 535                 540                 


Arg Arg Ile Gln 
545             


<210>  31
<211>  540
<212>  PRT
<213>  Norovirus

<400>  31

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Thr Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Ser Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Pro Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Ile Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Ala Gly Thr Gln Glu Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Arg Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Ser 
            340                 345                 350         


Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Arg Ile Gln Phe Ser 
        355                 360                 365             


Thr Asp Thr Ser Asn Asp Phe Glu Thr Gly Gln Asn Thr Arg Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Val Gln Asp Gly Ser Thr Thr His Gln Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Asp Ser His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Ser Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asn 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535                 540 


<210>  32
<211>  537
<212>  PRT
<213>  Norovirus

<400>  32

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Thr Ala 
1               5                   10                  15      


Ser Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Ser Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Ile Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Thr 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Gly Ile Thr Arg Ile Gly Gln Ser Glu Ser Tyr Lys Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Lys Gly Arg Ile Arg Gly Leu Leu Thr Gln 
                325                 330                 335     


Thr Thr Lys Gly Ala Gly Ser Thr Arg Gly His Lys Ala Thr Val Leu 
            340                 345                 350         


Thr Gly Gly Ser Asp Phe Thr Pro Lys Leu Gly Thr Val Arg Phe Asp 
        355                 360                 365             


Thr Lys Ser Ile Asp Phe Glu Asn Asn Gln Asn Thr Lys Phe Thr Pro 
    370                 375                 380                 


Val Gly Val Val Gln Asp Gly Asn Asn His Asp Glu Pro Thr Gln Trp 
385                 390                 395                 400 


Val Leu Pro Asn Tyr Ser Gly Pro Asp Thr His Asn Val His Leu Ala 
                405                 410                 415     


Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu Phe Phe Arg 
            420                 425                 430         


Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Lys Met Glu Leu Asp Cys 
        435                 440                 445             


Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu Ala Ala Pro 
    450                 455                 460                 


Ala Gln Thr Asp Val Ala Leu Leu Arg Phe Val Asn Pro Asp Thr Gly 
465                 470                 475                 480 


Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr Val Thr Val 
                485                 490                 495     


Ala His Thr Gly Asp His Asp Leu Val Ile Pro Pro Asn Gly Tyr Phe 
            500                 505                 510         


Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala Pro Met Gly 
        515                 520                 525             


Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535         


<210>  33
<211>  540
<212>  PRT
<213>  Norovirus

<400>  33

Met Lys Met Ala Ser Asn Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Leu Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Ser Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Ser Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Ile Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Thr Asn Glu Pro Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Glu Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ser 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Ala Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Ile Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Gly Glu Gly Ser Thr Arg Ala His Arg Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Pro Phe Thr Pro Lys Leu Gly Ser Val Gln Phe Thr 
        355                 360                 365             


Thr Asp Thr Asp Asn Asp Phe Asp Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Asp Thr Ala His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Val Gln Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Ala Gly Arg Arg Arg Ala Leu 
    530                 535                 540 


<210>  34
<211>  540
<212>  PRT
<213>  Norovirus

<400>  34

Met Lys Met Ala Ser Asn Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Ser Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Ser 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ala Thr Leu Asp Lys Leu Phe Thr Gly Pro Ser Ser Thr 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Met Ile Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Leu Arg Asp Ser Pro Ile Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Pro Asn Trp Asn Asn Tyr Asp Ser Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Lys Gly Glu Gly Ser Thr Arg Gly His Arg Ala Thr Val Tyr 
            340                 345                 350         


Val Gly Ser Ala Asn Tyr Thr Pro Lys Leu Gly Lys Val Gln Phe Glu 
        355                 360                 365             


Thr Asn Thr Thr Asn Asp Leu Tyr Ala His Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Val Gln Gly Gly Glu Ser Ala His Arg Ser Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Gly Tyr Ser Gly Arg Asp Thr Pro Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Ile Pro Gly Cys Gly Gly His Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Ser Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Lys Arg Ala Ile 
    530                 535                 540 


<210>  35
<211>  539
<212>  PRT
<213>  Norovirus

<400>  35

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Thr Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Ser Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Pro Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Ile Leu Thr Val Gly Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Asn Leu Glu Arg Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Asn Val Val Gln Pro Gln Asn Gly Arg Cys Thr Ile Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Ser Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Gly Ser Thr His His Trp Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Pro Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Thr Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile His Gly Met Leu Thr Gln 
                325                 330                 335     


Thr Thr Gln Gly Asn Gly Ser Thr Arg Gly His Arg Ala Thr Val Tyr 
            340                 345                 350         


Val Gly Ser Ala Glu Phe Thr Pro Lys Leu Gly Lys Val Gln Phe Lys 
        355                 360                 365             


Thr Glu Thr Asp His Asp Leu Ala Ile Arg Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Glu Ser Asp His His Arg Asp Glu Pro Gln 
385                 390                 395                 400 


Gln Trp Arg Leu Pro Asn Tyr Ser Gly Ala Asn Thr Phe Asn Val His 
                405                 410                 415     


Leu Ala Pro Ala Val Ala Pro Asn Phe Pro Gly Glu Gln Leu Leu Phe 
            420                 425                 430         


Phe Arg Ser Thr Leu Pro Gly Cys Gly Gly His Pro Asn Met Asp Leu 
        435                 440                 445             


Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu Ala 
    450                 455                 460                 


Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro Asp 
465                 470                 475                 480 


Thr Ser Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr Val 
                485                 490                 495     


Thr Val Ala His Thr Gly Gln Tyr Asp Leu Val Leu Pro Ser Asn Gly 
            500                 505                 510         


Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala Pro 
        515                 520                 525             


Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535                 


<210>  36
<211>  539
<212>  PRT
<213>  Norovirus

<400>  36

Met Lys Met Ala Ser Asn Asp Ala Ser Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Val Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Lys Asp Pro Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Glu Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Ser 
    210                 215                 220                 


Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Gly Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Leu Thr His Phe Thr Gly Thr Ser Glu Tyr Ala Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asp Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Ala Pro Asp Phe Val Gly Lys Ile Arg Gly Met Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Arg Asp Gly Ser Thr Arg Gly His Arg Ala Thr Leu Ser 
            340                 345                 350         


Thr Gly Ser Ala His Phe Thr Pro Lys Leu Gly Asn Ile Arg Phe Ser 
        355                 360                 365             


Thr Asp Thr Asn Asn Asp Phe Glu Ala Gly Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Phe Gln Glu Gly Asp Asn His Gln Asn Glu Pro Gln 
385                 390                 395                 400 


Gln Trp Val Leu Pro Asn Tyr Ser Gly Ala Thr Ala His Asn Val His 
                405                 410                 415     


Leu Ala Pro Ala Val Ala Pro Ala Phe Pro Gly Glu Gln Leu Leu Phe 
            420                 425                 430         


Phe Arg Ser Thr Met Pro Gly Cys Gly Gly Tyr Pro Asn Met Asn Leu 
        435                 440                 445             


Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu Ala 
    450                 455                 460                 


Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro Asp 
465                 470                 475                 480 


Thr Ser Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr Val 
                485                 490                 495     


Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn Gly 
            500                 505                 510         


Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala Pro 
        515                 520                 525             


Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535                 


<210>  37
<211>  539
<212>  PRT
<213>  Norovirus

<400>  37

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Thr Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Ala Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Ala Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Leu 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Met Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Ile Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Pro Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Val Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Asn Pro Phe Ser Val Pro Ile Leu Thr Ile Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Leu Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Thr Thr Lys Thr His Thr Tyr Gln Met Asn Leu Ala 
    290                 295                 300                 


Ala Gln Asn Trp Asn Ser Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Lys Gly Asn Gly Ser Thr Arg Ala His Lys Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Glu Phe Thr Pro Lys Leu Gly Arg Ile Gln Leu Phe 
        355                 360                 365             


Thr Asp Thr Asp Asn Asp Leu Glu Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Asp Thr His Gln Asn Glu Pro Gln 
385                 390                 395                 400 


Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Asn His Asn Val His 
                405                 410                 415     


Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu Phe 
            420                 425                 430         


Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asn Leu 
        435                 440                 445             


Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu Ala 
    450                 455                 460                 


Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro Asp 
465                 470                 475                 480 


Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr Val 
                485                 490                 495     


Thr Val Ala His Thr Gly His His Asp Leu Phe Ile Pro Pro Asn Gly 
            500                 505                 510         


Tyr Phe Arg Phe Asp Ser Trp Val Ser Pro Phe Tyr Thr Leu Ala Pro 
        515                 520                 525             


Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535                 


<210>  38
<211>  538
<212>  PRT
<213>  Norovirus

<400>  38

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Ile Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Lys Asp Ser Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Val Ala Gly Asp Thr Phe Ala Met Asn Leu Ala Ser 
    290                 295                 300                 


Leu Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Thr Pro Ala Pro Leu 
305                 310                 315                 320 


Gly Thr Pro Asp Phe Val Gly Arg Ile His Gly Met Leu Thr Gln Thr 
                325                 330                 335     


Thr Arg Ser Asp Gly Ala Thr Arg Ala His Lys Ala Thr Val Ser Thr 
            340                 345                 350         


Gly Gly Ala Asp Phe Thr Pro Lys Leu Gly Ser Val Arg Tyr Ser Thr 
        355                 360                 365             


Asp Thr Ser Ser Asp Leu Glu Val Arg Glu Asn Thr Lys Phe Thr Pro 
    370                 375                 380                 


Ile Gly Val Leu His Ser Ser Gly Gly His Arg Ala Glu Pro Asp Gln 
385                 390                 395                 400 


Trp Arg Leu Pro Glu Tyr Ser Gly Arg Asn Val His Asn Val His Leu 
                405                 410                 415     


Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu Phe Phe 
            420                 425                 430         


Arg Ser Thr Met Pro Gly Cys Gly Gly Tyr Pro Asn Met Asp Leu Asp 
        435                 440                 445             


Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu Ala Ala 
    450                 455                 460                 


Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro Asp Thr 
465                 470                 475                 480 


Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr Val Thr 
                485                 490                 495     


Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro Pro Asn Gly Tyr 
            500                 505                 510         


Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala Pro Met 
        515                 520                 525             


Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535             


<210>  39
<211>  539
<212>  PRT
<213>  Norovirus

<400>  39

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Val Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser His Asp Ser Thr Leu 
                165                 170                 175     


Lys Leu Ile Ala Val Leu Tyr Thr Pro Leu Arg Thr Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Asn Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Val Gly Ser His Glu Thr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Ser Asn Tyr Asp Pro Thr Gln Lys Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro His Phe Val Gly Lys Ile Gln Gly Leu Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Ala His Gly Ser Thr Arg Ala His Lys Ala Thr Val Ser 
            340                 345                 350         


Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val Gln Phe Thr 
        355                 360                 365             


Thr Asp Thr Asn Asn Asp Phe Gln Thr Gly Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Asp His His Gln Asn Glu Pro Gln 
385                 390                 395                 400 


Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His Asn Val His 
                405                 410                 415     


Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu Phe 
            420                 425                 430         


Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asn Leu 
        435                 440                 445             


Asp Cys Leu Leu Pro His Glu Trp Val Leu His Phe Tyr Gln Glu Ala 
    450                 455                 460                 


Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro Asp 
465                 470                 475                 480 


Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr Ile 
                485                 490                 495     


Thr Val Ala His Thr Gly Pro Phe Asp Leu Gly Ile Pro Pro Asn Gly 
            500                 505                 510         


Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala Pro 
        515                 520                 525             


Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535                 


<210>  40
<211>  539
<212>  PRT
<213>  Norovirus

<400>  40

Met Lys Met Ala Ser Asn Asp Ala Ser Pro Ser Asp Gly Ser Thr Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Ser Ser Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asp Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Ala Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Gly Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Ser Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Asn Cys Ser Arg Val Pro Ala Val Pro 
                245                 250                 255     


Leu Ser Ser Asn His Lys Met Gln Cys Thr Thr Asp Gly Val Leu Leu 
            260                 265                 270         


Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly Asp 
        275                 280                 285             


Val Thr His Ile Pro Gly Thr Arg Thr Tyr Arg Met Asn Leu Ala Ser 
    290                 295                 300                 


Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro Leu 
305                 310                 315                 320 


Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met Leu Thr Gln Thr 
                325                 330                 335     


Thr Lys Gly Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Ser Thr 
            340                 345                 350         


Gly Ser Val Asp Phe Thr Pro Lys Leu Gly Ser Val Gln Phe Ala Thr 
        355                 360                 365             


Asp Thr Asp Asn Asp Phe Glu Thr Gly Gln Asn Thr Arg Phe Thr Pro 
    370                 375                 380                 


Val Gly Val Ile Gln Asp Gly Ser Ser Thr His Arg Asn Glu Pro Gln 
385                 390                 395                 400 


Gln Trp Val Leu Pro Asp Tyr Ser Gly Arg Thr Val His Asn Val His 
                405                 410                 415     


Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu Phe 
            420                 425                 430         


Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp Leu 
        435                 440                 445             


Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu Ala 
    450                 455                 460                 


Ala Pro Ser Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro Asp 
465                 470                 475                 480 


Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ala Gly Tyr Val 
                485                 490                 495     


Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn Gly 
            500                 505                 510         


Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala Pro 
        515                 520                 525             


Met Gly Asn Gly Ala Gly Arg Arg Arg Ala Leu 
    530                 535                 


<210>  41
<211>  539
<212>  PRT
<213>  Norovirus

<400>  41

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Ser Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Ser Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Val Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ala Asn Asp Ser Thr Leu 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Thr Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Arg Leu Phe Thr Gly Pro Ser Thr Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Asn Phe Arg Gly 
        275                 280                 285             


Glu Val Asn His Ile Ala Gly Thr His Asp Tyr Thr Met Arg Leu Thr 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Arg Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Ser Asp Gly Ser Thr Arg Ser His Lys Ala Thr Val Ser 
            340                 345                 350         


Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val Gln Phe Thr 
        355                 360                 365             


Thr Asp Thr Thr Asn Asp Leu Asn Ala Gly Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Glu Gln Thr Ser Gly Asp His Gln Ser Glu Pro Gln 
385                 390                 395                 400 


Gln Trp Thr Leu Pro Asn Tyr Ser Gly Thr Pro Asn His Asn Val His 
                405                 410                 415     


Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu Phe 
            420                 425                 430         


Phe Arg Ser Thr Leu Pro Gly Cys Gly Gly Tyr Pro Asn Met Asn Leu 
        435                 440                 445             


Asp Cys Leu Leu Pro Gln Glu Trp Val Leu His Phe Tyr Gln Glu Ala 
    450                 455                 460                 


Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro Asp 
465                 470                 475                 480 


Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Arg Ser Gly Phe Ile 
                485                 490                 495     


Thr Val Ala His Ser Gly Ser His Asp Leu Val Ile Pro Pro Asn Gly 
            500                 505                 510         


Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala Pro 
        515                 520                 525             


Met Gly Asn Gly Ser Gly Arg Arg Arg Val Val 
    530                 535                 


<210>  42
<211>  540
<212>  PRT
<213>  Norovirus

<400>  42

Met Lys Met Ala Ser Asn Asp Ala Thr Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ser Asn Asn Glu Ala Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ser Leu Ala Ala Pro Val Thr Gly Gln Thr Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Thr Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Val Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Met Glu Val Gln Val Met Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Tyr Phe 
        115                 120                 125             


Pro Val Glu Asn Leu Ser Pro Ser Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Met Pro Asp 
145                 150                 155                 160 


Val Arg Ser Thr Leu Phe His Phe Asn Gln Lys Asp Glu Pro Lys Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Ile Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Glu Phe Asp Phe Thr Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Val Leu Thr Leu Gly Glu Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Leu Ser Ile Asp Glu Met Val Thr Ser Pro Asn Glu Ser 
                245                 250                 255     


Ile Val Val Gln Pro Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Gln Ala Cys Asn Ile Cys Ser Ile Arg Gly 
        275                 280                 285             


Lys Val Thr Gly Gln Val Pro Asn Glu Gln His Met Trp Asn Leu Gln 
    290                 295                 300                 


Ile Thr Asn Leu Asn Gly Thr Gln Phe Asp Pro Thr Asp Asp Val Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Val Pro Asp Phe Ala Gly Glu Val Phe Gly Val Leu 
                325                 330                 335     


Ser Gln Arg Asn Arg Gly Glu Ser Asn Pro Ala Asn Arg Ala His Asp 
            340                 345                 350         


Ala Val Val Ala Thr Tyr Ser Asp Lys Tyr Thr Pro Lys Leu Gly Leu 
        355                 360                 365             


Val Gln Ile Gly Thr Trp Asn Thr Asn Asp Val Glu Asn Gln Pro Thr 
    370                 375                 380                 


Lys Phe Thr Pro Ile Gly Leu Asn Glu Val Ala Asn Gly His Arg Phe 
385                 390                 395                 400 


Glu Gln Trp Thr Leu Pro Arg Tyr Ser Gly Ala Leu Thr Leu Asn Met 
                405                 410                 415     


Asn Leu Ala Pro Ala Val Ala Pro Leu Phe Pro Gly Glu Arg Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Tyr Val Pro Leu Lys Gly Gly Phe Gly Asn Pro Ala 
        435                 440                 445             


Ile Asp Cys Leu Val Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ser Ala Pro Ser Leu Gly Asp Val Ala Leu Val Arg Tyr Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Lys Gly Gly Phe 
                485                 490                 495     


Leu Thr Val Ser Ser Thr Ser Thr Gly Pro Val Val Val Pro Ala Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala 
        515                 520                 525             


Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Phe Gln 
    530                 535                 540 


<210>  43
<211>  547
<212>  PRT
<213>  Norovirus

<400>  43

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Ala Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Val Val Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Glu Asn Phe Val Gln Ala Pro Gln Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Met Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ser His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Met Gln Val Gln Val Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Val Lys Asn Ile Ser Ala Ala Gln Ile Thr Met Cys Pro His Val 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Ile Arg Asn Arg Phe Phe His Tyr Asn Gln Glu Asn Thr Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Ser Gly Glu 
            180                 185                 190         


Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ala Pro Asp 
        195                 200                 205             


Phe Glu Phe Thr Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr Lys 
    210                 215                 220                 


Pro Phe Thr Leu Pro Ile Leu Thr Leu Gly Glu Leu Ser Asn Ser Arg 
225                 230                 235                 240 


Phe Pro Ala Pro Ile Asp Met Leu Tyr Thr Asp Pro Asn Glu Gly Ile 
                245                 250                 255     


Val Val Gln Pro Gln Asn Gly Arg Cys Thr Leu Asp Gly Thr Leu Gln 
            260                 265                 270         


Gly Thr Thr Gln Leu Val Pro Thr Gln Ile Cys Ala Phe Arg Gly Thr 
        275                 280                 285             


Leu Ile Gly Gln Thr Ser Arg Ser Ser Asp Ser Thr Asp Ser Ala Pro 
    290                 295                 300                 


Arg Arg Arg Asp His Pro Leu His Val Gln Leu Lys Asn Leu Asp Gly 
305                 310                 315                 320 


Thr Gln Tyr Asp Pro Thr Asp Glu Val Pro Ala Val Leu Gly Ala Ile 
                325                 330                 335     


Asp Phe Lys Gly Thr Val Phe Gly Val Ala Ser Gln Arg Asp Val Ser 
            340                 345                 350         


Gly Gln Gln Val Gly Ala Thr Arg Ala His Glu Val His Ile Asn Thr 
        355                 360                 365             


Thr Asp Pro Arg Tyr Thr Pro Lys Leu Gly Ser Ile Leu Ile His Ser 
    370                 375                 380                 


Glu Ser Asp Asp Phe Val Thr Gly Gln Pro Val Arg Phe Thr Pro Ile 
385                 390                 395                 400 


Gly Met Gly Asp Asn Asp Trp His Gln Trp Glu Leu Pro Asp Tyr Ser 
                405                 410                 415     


Gly His Leu Thr Leu Asn Met Asn Leu Ala Pro Ala Val Ala Pro Ala 
            420                 425                 430         


Phe Pro Gly Glu Arg Ile Leu Phe Phe Arg Ser Met Val Pro Ser Ala 
        435                 440                 445             


Gly Gly Tyr Gly Ser Gly Gln Ile Asp Cys Leu Ile Pro Gln Glu Trp 
    450                 455                 460                 


Val Gln His Phe Tyr Gln Glu Ala Ala Pro Ser Gln Ser Ala Val Ala 
465                 470                 475                 480 


Leu Ile Arg Tyr Val Asn Pro Asp Thr Gly Arg Asn Ile Phe Glu Ala 
                485                 490                 495     


Lys Leu His Arg Glu Gly Phe Ile Thr Val Ala Asn Ser Gly Asn Asn 
            500                 505                 510         


Pro Ile Val Val Pro His Asn Gly Tyr Phe Arg Phe Glu Ala Trp Val 
        515                 520                 525             


Asn Gln Phe Tyr Thr Leu Thr Pro Met Gly Thr Gly Gln Gly Arg Arg 
    530                 535                 540                 


Arg Asn Gln 
545         


<210>  44
<211>  540
<212>  PRT
<213>  Norovirus

<400>  44

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Asn Glu Val Met Pro Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Leu Ala Thr Pro Val Val Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Ala Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asp Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly His Ala Gly Gly Met Glu Val Gln Ile Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Ile Pro Pro Gly Phe 
        115                 120                 125             


Pro Tyr Glu Asn Leu Ser Pro Ser Gln Ile Thr Met Cys Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Gln Leu Glu Pro Val Leu Leu Pro Met Pro Asp 
145                 150                 155                 160 


Ile Arg Asn Asn Phe Phe His Tyr Asn Gln Gly Asn Asp Pro Lys Leu 
                165                 170                 175     


Arg Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Lys Pro Ser Pro 
        195                 200                 205             


Asp Phe Glu Phe Thr Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Gln Phe Thr Leu Pro Ile Leu Lys Ile Ser Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Val Glu Met Met Tyr Thr Ala Arg Asn Glu Asn 
                245                 250                 255     


Gln Val Val Gln Pro Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Pro Leu Leu Ala Val Asn Ile Cys Lys Phe Lys Gly 
        275                 280                 285             


Glu Val Ile Ala Lys Asn Gly Asp Val Arg Ser Tyr Arg Met Asp Met 
    290                 295                 300                 


Glu Ile Thr Asn Thr Asp Gly Thr Pro Ile Asp Pro Thr Glu Asp Thr 
305                 310                 315                 320 


Pro Gly Pro Ile Gly Ser Pro Asp Phe Gln Gly Ile Leu Phe Gly Val 
                325                 330                 335     


Ala Ser Gln Arg Asn Lys Asn Glu Gln Asn Pro Ala Thr Arg Ala His 
            340                 345                 350         


Glu Ala Asn Ile Asn Thr Gly Gly Asp Gln Tyr Ala Pro Lys Leu Ala 
        355                 360                 365             


Gln Val Lys Phe Phe Ser Glu Ser Gln Asp Phe Glu Val His Gln Pro 
    370                 375                 380                 


Thr Val Phe Thr Pro Val Gly Val Ala Gly Asp Thr Ser His Pro Phe 
385                 390                 395                 400 


Arg Gln Trp Val Leu Pro Arg Tyr Gly Gly His Leu Thr Asn Asn Thr 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Leu Phe Pro Gly Glu Gln Ile Leu 
            420                 425                 430         


Phe Phe Arg Ser Gln Ile Pro Ser Ser Gly Gly His Glu Leu Gly Tyr 
        435                 440                 445             


Met Asp Cys Leu Val Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Thr Ala Gln Ser Glu Val Ala Leu Ile Arg Phe Ile Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Lys Gln Gly Phe 
                485                 490                 495     


Ile Thr Val Ala His Thr Gly Asp Asn Pro Ile Val Met Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Glu Ala Trp Val Asn Gln Phe Tyr Ser Leu Ala 
        515                 520                 525             


Pro Val Gly Thr Gly Asn Gly Arg Arg Arg Ile Gln 
    530                 535                 540 


<210>  45
<211>  537
<212>  PRT
<213>  Norovirus

<400>  45

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn His Glu Val Met Ala Ile Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Leu Ala Ala Pro Val Val Gly Gln Leu Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Ala Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Phe Leu Leu Asp Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly His Ala Gly Gly Met Glu Val Gln Ile Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Val Ile Pro Pro Gly Phe 
        115                 120                 125             


Pro Tyr Glu Asn Leu Ser Pro Ala Gln Leu Thr Met Cys Pro His Val 
    130                 135                 140                 


Val Val Asp Val Arg Gln Leu Glu Pro Ile Leu Leu Pro Met Pro Asp 
145                 150                 155                 160 


Ile Arg Asn Thr Phe Phe His Tyr Asn Gln Ser Asn Gly Pro Lys Leu 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Glu Phe Asn Phe Leu Val Pro Pro Ser Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Ala Phe Thr Leu Pro Ile Leu Lys Ile Ser Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Val Asp Gln Met Tyr Thr Ser Arg Asn Glu Asn 
                245                 250                 255     


Val Val Val Gln Pro Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Thr Leu Gln Pro Val Ser Ile Cys Gly Phe Arg Gly 
        275                 280                 285             


Thr Leu Gln Thr Arg Leu Ala Asp Gln Pro Asn Tyr Thr Tyr Gln Val 
    290                 295                 300                 


His Leu Glu Asn Leu Asp Gly Ser Pro Val Asp Pro Thr Asp Glu Val 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Gln Ala Gln Leu Phe Gly Val 
                325                 330                 335     


Val Ser Gln Arg Ser Ser Asp Asn Ala Thr Arg Ala His Glu Ala Arg 
            340                 345                 350         


Val Asn Thr Asn Asp Pro Thr Phe Ala Pro Gln Ile Ala Gln Val Arg 
        355                 360                 365             


Phe Lys Ser Pro Ser His Asp Phe Phe Asp Asn Glu Pro Ile Lys Phe 
    370                 375                 380                 


Thr Pro Val Gly Ile Ser Val Asp Ser Glu Asn Ser Tyr Asn Gln Trp 
385                 390                 395                 400 


Leu Leu Pro Arg Tyr Gly Gly His Leu Thr Asn Asn Thr His Leu Ala 
                405                 410                 415     


Pro Ser Val Ser Pro Met Phe Pro Gly Glu Gln Ile Leu Phe Phe Arg 
            420                 425                 430         


Ser Phe Met Pro Gly Ala Ser Gly His Thr Asp Gly Ala Ile Asp Cys 
        435                 440                 445             


Leu Leu Pro Gln Glu Trp Val Ala His Phe Tyr Gln Glu Ala Ala Thr 
    450                 455                 460                 


Ala Gln Thr Asp Val Ala Leu Ile Arg Phe Val Asn Pro Asp Thr Gly 
465                 470                 475                 480 


Arg Val Leu Phe Glu Gly Lys Leu His Lys Gln Gly Phe Ile Thr Ile 
                485                 490                 495     


Ser Asn Ser Gly Asp His Pro Ile Val Met Pro Ala Asn Gly Tyr Phe 
            500                 505                 510         


Arg Phe Glu Ala Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro Val Gly 
        515                 520                 525             


Thr Gly Ser Gly Arg Arg Arg Ile Gln 
    530                 535         


<210>  46
<211>  535
<212>  PRT
<213>  Norovirus

<400>  46

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Gly Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Glu Leu Tyr Thr Ser Pro Asn Glu Ser 
                245                 250                 255     


Leu Val Val Gln Pro Gln Asn Gly Arg Cys Ala Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Pro Thr Ala Ile Cys Ser Phe Arg Gly 
        275                 280                 285             


Arg Ile Asn Gln Lys Val Ser Gly Glu Asn His Val Trp Asn Met Gln 
    290                 295                 300                 


Ile Thr Asn Ile Asn Gly Thr Pro Phe Asp Pro Thr Glu Asp Val Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Thr Pro Asp Phe Ser Gly Lys Leu Phe Gly Val Leu 
                325                 330                 335     


Ser Gln Arg Asp His Asp Asn Ala Cys Arg Ser His Asp Ala Val Ile 
            340                 345                 350         


Ala Thr Asn Ser Ala Lys Phe Thr Pro Lys Leu Gly Ala Ile Gln Ile 
        355                 360                 365             


Gly Thr Trp Glu Gln Asp Asp Val His Ile Asn Gln Pro Thr Lys Phe 
    370                 375                 380                 


Thr Pro Val Gly Leu Phe Glu Ser Glu Gly Phe Asn Gln Trp Thr Leu 
385                 390                 395                 400 


Pro Asn Tyr Ser Gly Ala Leu Thr Leu Asn Met Gly Leu Ala Pro Pro 
                405                 410                 415     


Val Ala Pro Thr Phe Pro Gly Glu Gln Ile Leu Phe Phe Arg Ser His 
            420                 425                 430         


Ile Pro Leu Lys Gly Gly Val Ala Asp Pro Val Ile Asp Cys Leu Leu 
        435                 440                 445             


Pro Gln Glu Trp Ile Gln His Leu Tyr Gln Glu Ser Ala Pro Ser Gln 
    450                 455                 460                 


Thr Asp Val Ala Leu Ile Arg Phe Thr Asn Pro Asp Thr Gly Arg Val 
465                 470                 475                 480 


Leu Phe Glu Ala Lys Leu His Arg Ser Gly Tyr Ile Thr Val Ala Asn 
                485                 490                 495     


Thr Gly Ser Arg Pro Ile Val Val Pro Ala Asn Gly Tyr Phe Arg Phe 
            500                 505                 510         


Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro Met Gly Thr Gly 
        515                 520                 525             


Asn Gly Arg Arg Arg Val Gln 
    530                 535 


<210>  47
<211>  528
<212>  PRT
<213>  Norovirus

<400>  47

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Ser Leu Val Pro Glu Ala Ile Asn Glu Thr Met Pro Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Val Ala Gly Gln Thr Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Thr Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Ile Pro Pro Asn Phe 
        115                 120                 125             


Pro Val Asp Met Ile Ser Pro Ala Gln Ile Thr Met Leu Pro His Leu 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Leu Glu Pro Ile Met Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Val Phe Tyr His Phe Asn Asn Gln Pro Gln Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Thr Pro 
        195                 200                 205             


Asp Phe Glu Phe Ile Tyr Leu Val Pro Pro Ser Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Ser Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Ile Glu Gln Leu Tyr Thr Ala Pro Asn Glu Asn 
                245                 250                 255     


Asn Val Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Ser Ser Ala Val Cys Ser Tyr Arg Gly 
        275                 280                 285             


Arg Thr Val Ala Asn Arg Gly Asp Asn Trp Asp Gln Asn Leu Leu Gln 
    290                 295                 300                 


Leu Thr Tyr Pro Ser Gly Ala Ser Tyr Asp Pro Thr Asp Glu Val Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Thr Gln Asp Phe Ser Gly Ile Leu Tyr Gly Val Leu 
                325                 330                 335     


Thr Gln Asp Asn Val Ser Glu Gly Thr Gly Glu Ala Lys Asn Ala Lys 
            340                 345                 350         


Gly Val Tyr Ile Ser Thr Thr Ser Gly Lys Phe Thr Pro Lys Ile Gly 
        355                 360                 365             


Ser Ile Gly Leu His Ser Ile Thr Glu Asn Val His Pro Asn Gln Gln 
    370                 375                 380                 


Ser Arg Phe Thr Pro Val Gly Val Ala Gln Asn Glu Asn Thr Pro Phe 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro His Tyr Ala Gly Ala Leu Ala Leu Asn Thr 
                405                 410                 415     


Asn Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Arg Val Pro Cys Val Gln Gly Leu Arg Gly Gln Asp 
        435                 440                 445             


Ala Phe Ile Asp Cys Leu Leu Pro Gln Glu Trp Val Asn His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ser Gln Ala Asp Val Ala Leu Ile Arg Tyr Val 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Thr Leu Phe Glu Ala Lys Leu His Arg Ser 
                485                 490                 495     


Gly Phe Ile Thr Val Ser His Thr Gly Ala Tyr Pro Leu Val Val Pro 
            500                 505                 510         


Pro Asn Gly His Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser 
        515                 520                 525             


<210>  48
<211>  536
<212>  PRT
<213>  Norovirus

<400>  48

Met Lys Met Ala Ser Asn Asp Ala Thr Pro Ser Asp Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Val Val Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Ala Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Leu Leu Leu Asp Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly His Ala Gly Gly Met Glu Val Gln Ile Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Ile Pro Pro Ser Phe 
        115                 120                 125             


Pro Tyr Glu Asn Leu Ser Pro Ala Gln Leu Thr Met Cys Pro His Val 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Leu Pro Met Pro Asp 
145                 150                 155                 160 


Ile Arg Asn Val Phe Tyr His Tyr Asn Gln Asn Asn Ser Pro Lys Leu 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Gln Phe Thr Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Asn Phe Thr Leu Pro Val Leu Arg Val Ser Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Val Leu Asp Gln Met Tyr Thr Ser Arg Asn Glu Asn 
                245                 250                 255     


Ile Ile Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Thr Leu Gln Ser Val Ser Ile Cys Asn Phe Arg Gly 
        275                 280                 285             


Thr Met Gln Ala Lys Leu Asn Glu Gln Pro Arg Tyr Gln Leu Gln Leu 
    290                 295                 300                 


Thr Asn Leu Asp Gly Ser Pro Ile Asp Pro Thr Asp Asp Met Pro Ala 
305                 310                 315                 320 


Pro Leu Gly Thr Pro Asp Phe Gln Ala Met Leu Tyr Gly Val Ala Ser 
                325                 330                 335     


Gln Arg Ser Ser Arg Asp Asn Ala Thr Arg Ala His Asp Ala Gln Ile 
            340                 345                 350         


Asp Thr Ala Gly Asp Thr Phe Ala Pro Lys Ile Gly Gln Val Arg Phe 
        355                 360                 365             


Lys Ser Ser Ser Asp Asp Phe Asp Leu His Asp Pro Thr Lys Phe Thr 
    370                 375                 380                 


Pro Ile Gly Val Asn Val Asp Asp Gln His Pro Phe Arg Gln Trp Ser 
385                 390                 395                 400 


Leu Pro Asn Tyr Gly Gly His Leu Ala Leu Asn Asn His Leu Ala Pro 
                405                 410                 415     


Ala Val Thr Pro Leu Phe Pro Gly Glu Gln Ile Leu Phe Phe Arg Ser 
            420                 425                 430         


His Ile Pro Ser Ala Gly Gly His Thr Asp Gly Ala Ile Asp Cys Leu 
        435                 440                 445             


Leu Pro Gln Glu Trp Ile Glu His Phe Tyr Gln Glu Ala Ala Pro Ser 
    450                 455                 460                 


Gln Ser Asp Ile Ala Leu Val Arg Phe Ile Asn Pro Asp Thr Gly Arg 
465                 470                 475                 480 


Val Leu Leu Glu Ala Lys Leu His Lys Gln Gly Phe Leu Thr Val Ala 
                485                 490                 495     


Ala Ser Gly Asp His Pro Ile Val Met Pro Thr Asn Gly Tyr Phe Arg 
            500                 505                 510         


Phe Glu Ala Trp Val Asn Pro Phe Tyr Thr Leu Ala Pro Val Gly Thr 
        515                 520                 525             


Gly Ser Gly Arg Arg Arg Ile Gln 
    530                 535     


<210>  49
<211>  538
<212>  PRT
<213>  Norovirus

<400>  49

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Gly Asn Asn Glu Thr Leu Pro Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Ile Ala Ala Pro Val Thr Gly Gln Asn Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Thr Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Val Glu Phe Leu Ser Pro Ala Gln Ile Thr Met Leu Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Leu Glu Pro Ile Met Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Thr Phe Phe His Tyr Asn Asn Gln Pro Asn Ser Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Thr Pro 
        195                 200                 205             


Asp Phe Glu Phe Thr Tyr Leu Val Pro Pro Ser Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Ser Leu Pro Ile Leu Thr Leu Ser Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Ser Leu Phe Thr Ala Gln Asn Asn Val 
                245                 250                 255     


Leu Gln Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Pro Ser Gly Ile Cys Ala Phe Arg Gly 
        275                 280                 285             


Arg Val Thr Ala Glu Thr Asp Asn Pro Asp Lys Trp His Met Gln Leu 
    290                 295                 300                 


Gln Asn Leu Asn Gly Thr Thr Tyr Asp Pro Thr Asp Asp Val Pro Ala 
305                 310                 315                 320 


Pro Leu Gly Thr Pro Asp Phe Lys Gly Val Val Phe Gly Val Ala Ser 
                325                 330                 335     


Gln Arg Asn Val Gly Asn Asp Ala Pro Gly Ser Thr Arg Ala His Glu 
            340                 345                 350         


Ala Val Ile Ser Thr Tyr Ser Pro Lys Phe Val Pro Lys Leu Gly Ser 
        355                 360                 365             


Val Asn Phe Arg Ser Asn Asp Asp Asp Phe Gln Leu Gln Pro Thr Arg 
    370                 375                 380                 


Phe Thr Pro Val Gly Ile Asn Asp Asp Gly Asn His Pro Phe Arg Gln 
385                 390                 395                 400 


Trp Glu Leu Pro Asp Tyr Ser Gly Val Leu Thr Leu Asn Met Asn Leu 
                405                 410                 415     


Ala Pro Pro Val Ala Pro Asn Phe Pro Gly Glu Gln Leu Leu Leu Phe 
            420                 425                 430         


Arg Ser Phe Val Pro Cys Ser Gly Gly Tyr Asn Gln Gly Ile Ile Asp 
        435                 440                 445             


Cys Leu Ile Pro Gln Glu Trp Ile Gln His Phe Tyr Gln Glu Ser Ala 
    450                 455                 460                 


Pro Ser Gln Ser Asp Val Ala Leu Ile Arg Tyr Val Asn Pro Asp Thr 
465                 470                 475                 480 


Gly Arg Thr Leu Phe Glu Ala Lys Leu His Arg Ser Gly Tyr Ile Thr 
                485                 490                 495     


Val Ala His Ser Gly Asp Tyr Pro Leu Val Val Pro Ala Asn Gly Tyr 
            500                 505                 510         


Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro Met 
        515                 520                 525             


Gly Thr Gly Asn Gly Arg Arg Arg Ala Gln 
    530                 535             


<210>  50
<211>  540
<212>  PRT
<213>  Norovirus

<400>  50

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Thr 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Asn Glu Thr Leu Pro Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Ile Ala Ala Pro Val Thr Gly Gln Asn Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Thr Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Val Glu Phe Leu Ser Pro Ala Gln Ile Thr Met Leu Pro His Leu 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Leu Glu Pro Ile Met Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Thr Phe Phe His Tyr Asn Asn Gln Pro Ala Asn Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Thr Pro 
        195                 200                 205             


Asp Phe Glu Phe Thr Tyr Leu Val Pro Pro Ser Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Ser Leu Pro Ile Leu Thr Ile Ser Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ala Pro Ile Asp Ser Leu Phe Thr Ala Gln Asn Asn Asn 
                245                 250                 255     


Leu Asn Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Pro Ser Gly Ile Cys Ala Phe Arg Gly 
        275                 280                 285             


Arg Leu Thr Ala Asp Val Asp Gly Ser His Asp Asp Arg Trp His Met 
    290                 295                 300                 


Gln Leu Thr Asn Leu Asn Gly Thr Pro Phe Asp Pro Thr Glu Asp Val 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Thr Gly Leu Leu Phe Gly Val 
                325                 330                 335     


Ala Ser Gln Arg Asn Val Gly Ser Asn Pro Asn Thr Thr Arg Ala His 
            340                 345                 350         


Glu Ala Val Ile Ser Thr Thr Ser Ser Gln Phe Val Pro Lys Leu Gly 
        355                 360                 365             


Ser Val Asn Phe Gly Ser Thr Ser Thr Asp Phe Gln Leu Gln Gln Pro 
    370                 375                 380                 


Thr Lys Phe Thr Pro Val Gly Ile Lys Ile Glu Ser Gly His Glu Phe 
385                 390                 395                 400 


Asp Gln Trp Ala Leu Pro Arg Tyr Ser Gly His Leu Thr Leu Asn Met 
                405                 410                 415     


Asn Leu Ala Pro Pro Ile Ala Pro Asn Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Asn Val Pro Cys Ala Gly Gly Val Ser Asp Gly Val 
        435                 440                 445             


Ile Asp Cys Leu Leu Pro Gln Glu Trp Ile Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ser Ala Pro Ser Gln Ser Asp Val Ala Leu Ile Arg Tyr Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Thr Leu Phe Glu Ala Lys Leu His Arg Thr Gly Tyr 
                485                 490                 495     


Ile Thr Val Ala His Ser Gly Asp Tyr Pro Leu Val Val Pro Ser Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala 
        515                 520                 525             


Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Val Gln 
    530                 535                 540 


<210>  51
<211>  540
<212>  PRT
<213>  Norovirus

<400>  51

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Thr Glu Thr Leu Pro Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Ile Ala Ala Pro Val Thr Gly Gln Asn Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Met Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Val Asp Met Leu Ser Pro Ala Gln Ile Thr Met Leu Pro His Leu 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Leu Glu Pro Ile Met Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Val Phe Tyr His Phe Asn Asn Gln Pro Ala Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Thr Pro 
        195                 200                 205             


Asp Phe Glu Phe Thr Tyr Leu Val Pro Pro Ser Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Gly Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ala Pro Ile Asp Gln Leu Tyr Thr Ser Pro Asn Ala Asp 
                245                 250                 255     


Val Val Val Gln Pro Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Thr Thr Ala Ile Cys Ser Tyr Arg Gly 
        275                 280                 285             


Thr Thr Ser Asn Pro Thr Ser Asp Tyr Trp Asp Asp His Leu Leu His 
    290                 295                 300                 


Leu Val His Pro Asn Gly Ala Thr Tyr Asp Pro Thr Glu Asp Val Pro 
305                 310                 315                 320 


Ala Pro Phe Gly Thr Gln Asp Phe Arg Gly Ile Leu Tyr Gly Val Leu 
                325                 330                 335     


Thr Gln Asn Thr Gln Asn Pro Arg Asp Glu Val Ser Asn Ser Arg Gly 
            340                 345                 350         


Ile Tyr Ile Ser Ser Thr Ser Asp Lys Phe Thr Pro Lys Leu Gly Thr 
        355                 360                 365             


Ile Gly Leu His Gln Val Gln Gly Asp Thr Ala Ser Asn Gln Gln Ser 
    370                 375                 380                 


Lys Phe Thr Pro Val Gly Ile Ala Val Asn Gln Asn Thr Pro Phe Lys 
385                 390                 395                 400 


Gln Trp Glu Leu Pro Asn Tyr Ser Gly Ala Leu Thr Leu Asn Thr Asn 
                405                 410                 415     


Leu Ala Pro Ala Val Gly Pro Asn Phe Pro Gly Glu Gln Ile Leu Phe 
            420                 425                 430         


Phe Arg Ser Asn Val Pro Ser Val Gln Gly Asn His Pro Thr Gln Glu 
        435                 440                 445             


Ile Asp Cys Leu Ile Pro Gln Glu Trp Ile Ser His Phe Tyr Gln Glu 
    450                 455                 460                 


Ser Ala Pro Ser Gln Ser Asp Val Ala Leu Val Arg Tyr Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Thr Ile Phe Glu Ala Lys Leu His Arg Gln Gly Phe 
                485                 490                 495     


Ile Thr Ile Ala Ala Thr Gly Ser Asn Pro Val Val Val Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ala Leu Ala 
        515                 520                 525             


Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Ala Gln 
    530                 535                 540 


<210>  52
<211>  541
<212>  PRT
<213>  Norovirus

<400>  52

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Thr Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Gly Ala Ile Ala Ala Pro Leu Thr Gly Gln Thr Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Ile Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asn Met Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Phe Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Phe Ala Gly Gly Met Glu Val Gln Val Leu Met Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Val Ile Phe Ala Ala Ile Pro Pro His Phe 
        115                 120                 125             


Pro Val Glu Asn Leu Ser Pro Pro Gln Ile Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Met Pro Asp 
145                 150                 155                 160 


Val Arg Asn Gln Phe Phe His Tyr Asn Gln Val Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Thr 
            180                 185                 190         


Glu Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Glu Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Gly Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ala Pro Ile Asp Met Leu Tyr Thr Ser Pro Asn Asp Asn 
                245                 250                 255     


Val Val Val Gln Pro Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Ser Thr Gln Leu Val Pro Ala Asn Val Cys Ala Phe Lys Gly 
        275                 280                 285             


Lys Ile Thr Ala Arg Ile Val Asp Gln Ala Ala His Gln Trp His Met 
    290                 295                 300                 


Gln Ile Asp Asn Pro Asn Gly Thr Leu Phe Asp Pro Thr Glu Asp Val 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Lys Ala Lys Ile Phe Gly Val 
                325                 330                 335     


Ile Ser Gln Arg Asn Asp Tyr Asn Asp Gly Ser Gln Gly Pro Ala Asn 
            340                 345                 350         


Arg Ala His Asp Ala Val Val Pro Thr Thr Ser Ala Lys Phe Thr Pro 
        355                 360                 365             


Lys Leu Gly Ser Ile Leu Val Gly Thr Trp Glu Asn Asn Asp Ile Glu 
    370                 375                 380                 


Thr Gln Pro Ser Lys Phe Thr Pro Val Gly Leu Leu Glu Met Asn Asp 
385                 390                 395                 400 


Phe Asn Gln Trp Ser Leu Pro Asn Tyr Ser Gly Ala Leu Thr Leu Asn 
                405                 410                 415     


Met Gly Leu Ala Pro Ala Val Phe Pro Thr Phe Pro Gly Glu Gln Ile 
            420                 425                 430         


Leu Phe Phe Arg Ser Phe Ile Pro Leu Lys Gly Gly His Gly Asn Pro 
        435                 440                 445             


Ala Ile Asp Cys Leu Leu Pro Gln Glu Trp Ile Gln His Phe Tyr Gln 
    450                 455                 460                 


Glu Ser Ala Pro Ser Gln Thr Ser Val Ala Leu Ile Arg Tyr Val Asn 
465                 470                 475                 480 


Pro Asp Thr Gly Arg Val Leu Phe Glu Gly Lys Leu His Arg Gln Gly 
                485                 490                 495     


Phe Ile Thr Ile Ala Lys Ser Gly Asp Gly Pro Ile Val Val Pro Pro 
            500                 505                 510         


Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu 
        515                 520                 525             


Ala Pro Met Gly Asn Gly Asn Gly Arg Arg Arg Ile Gln 
    530                 535                 540     


<210>  53
<211>  542
<212>  PRT
<213>  Norovirus

<400>  53

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Ala Asn Lys Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Gly Ala Ile Ala Ala Pro Leu Thr Gly Gln Thr Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Met Asn Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Ile Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Phe Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Ile Met Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Val Ile Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Val Asp Asn Leu Ser Pro Pro Gln Val Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Phe Glu Pro Ile Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Ser Phe Tyr His Tyr Asn Gln Val Asn Asp Ser Arg Met 
                165                 170                 175     


Arg Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Ser 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Thr Pro 
        195                 200                 205             


Asp Phe Glu Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Ile Leu Thr Ile Gly Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Leu Pro Ile Asp Met Leu Tyr Thr Ser Pro Thr Glu Asn 
                245                 250                 255     


Ile Val Val Gln Pro Gln Asn Gly Arg Cys Thr Leu Glu Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Val Thr Pro Asn Ile Cys Ala Leu Arg Gly 
        275                 280                 285             


Glu Ile Arg Gly His Glu Gly Ser Gly Asp Asn His Lys Trp His Phe 
    290                 295                 300                 


Met Val Arg Ser Pro Asn Gly Ala Ala Phe Asp Pro Thr Glu Asp Val 
305                 310                 315                 320 


Pro Ala Pro Leu Gly Thr Pro Asp Phe Ile Gly Asp Val Phe Gly Val 
                325                 330                 335     


Leu Ser Gln Arg Asn Arg Asn Thr Asp Ser Gly Gln Ser Gly Pro Ala 
            340                 345                 350         


Asn Arg Ser His Asp Ala Val Val Ser Thr Arg Asp Ser Arg Phe Thr 
        355                 360                 365             


Pro Lys Leu Gly Ser Val Met Ile Ala Thr Trp Glu Thr Ser Asp Ile 
    370                 375                 380                 


Gln Asp Gln Pro Thr Arg Phe Thr Pro Val Gly Leu Glu Asn Pro Asp 
385                 390                 395                 400 


His Tyr Asn Gln Trp Gln Leu Pro Asn Tyr Ser Gly Ala Leu Thr Leu 
                405                 410                 415     


Asn Met Gly Leu Ala Pro Ser Val Phe Pro Thr Tyr Pro Gly Glu Gln 
            420                 425                 430         


Ile Leu Phe Phe Arg Ser Tyr Ile Pro Leu Lys Gly Gly Tyr Gly Asp 
        435                 440                 445             


Ser His Ile Asp Cys Leu Val Pro Gln Glu Trp Ile Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ser Ala Pro Ser Gln Thr Asp Val Ala Leu Ile Arg Tyr Val 
465                 470                 475                 480 


Asn Pro Glu Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Arg Gln 
                485                 490                 495     


Gly Tyr Ile Thr Val Ala Arg Ser Gly Ser Ser Pro Ile Asn Val Pro 
            500                 505                 510         


Ala Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser 
        515                 520                 525             


Leu Ala Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Ile Gln 
    530                 535                 540         


<210>  54
<211>  541
<212>  PRT
<213>  Norovirus

<400>  54

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Gly Ala Ile Ala Ala Pro Leu Thr Gly Gln Thr Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Thr Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Ile Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Met Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Phe Leu Gly His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Ile Glu Val Gln Val Leu Met Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Val Ile Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Val Glu Asn Leu Ser Pro Pro Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Leu Glu Pro Ile Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Gln Phe Phe His Tyr Ser Gln Val Asp Glu Pro Lys Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Ala 
            180                 185                 190         


Glu Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Glu Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Thr Val Pro Ile Leu Thr Ile Gly Glu Met Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ala Pro Ile Asp Met Leu Tyr Thr Ser Pro Asn Asp Asn 
                245                 250                 255     


Gln Asn Val Gln Pro Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Val Pro Ser Gly Val Cys Ala Phe Arg Gly 
        275                 280                 285             


Arg Ile Thr Gly His Glu Gly Ser Glu Gln Asn Gln Trp His Met Gln 
    290                 295                 300                 


Leu Thr Asn Leu Asn Gly Thr Pro Phe Asp Pro Thr Glu Asp Ile Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Thr Pro Asp Phe Lys Gly Glu Ile Phe Gly Phe Ile 
                325                 330                 335     


Ser Gln Arg Asn Ala Gln Asn Asp Pro Gly Gln Ser Gln Pro Ala Asn 
            340                 345                 350         


Arg Ala His Asp Ala Val Val Ser Thr Arg Ala Pro Lys Phe Thr Pro 
        355                 360                 365             


Lys Leu Gly Ser Val Met Ile Gly Thr Trp Val Asn Ser Asp Ile Glu 
    370                 375                 380                 


Asn Gln Pro Ser Lys Phe Thr Pro Val Gly Leu Asn Ser Asn Glu Asn 
385                 390                 395                 400 


Phe Arg Gln Trp Glu Leu Pro Asp Tyr Ser Gly Val Leu Thr Leu Asn 
                405                 410                 415     


Met Gly Leu Ala Pro Val Val His Pro Thr Tyr Pro Gly Glu Gln Ile 
            420                 425                 430         


Leu Phe Phe Arg Ser Tyr Ile Pro Leu Lys Gly Gly His Gly Asn Pro 
        435                 440                 445             


Ala Ile Asp Cys Leu Leu Pro Gln Glu Trp Ile Gln His Phe Tyr Gln 
    450                 455                 460                 


Glu Ser Ala Pro Ser Gln Thr Asp Val Ala Leu Leu Arg Tyr Val Asn 
465                 470                 475                 480 


Pro Asp Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Arg Gln Gly 
                485                 490                 495     


Tyr Ile Thr Ile Ala Lys Ser Gly Asp Gly Pro Ile Val Val Pro Pro 
            500                 505                 510         


Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu 
        515                 520                 525             


Ala Pro Met Gly Asn Gly Asn Gly Arg Arg Arg Val Gln 
    530                 535                 540     


<210>  55
<211>  556
<212>  PRT
<213>  Norovirus

<400>  55

Met Lys Met Ala Ser Ser Asp Ala Ala Pro Ser Thr Asp Gly Ala Gly 
1               5                   10                  15      


Asn Leu Val Pro Glu Ser Gln Gln Glu Val Leu Pro Leu Ala Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Leu Ala Ala Pro Val Val Gly Gln Thr Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Lys Glu Asn Phe Val Gln Ala Pro Gln Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Lys Asn Ser Pro Gly Glu Ile Leu Val Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Lys Leu Asn Pro Tyr Leu Asp His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Ser Tyr Ala Gly Gly Ile Asp Val Met Val Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Val Leu Ile Ala Ala Ile Pro Pro Asn Phe 
        115                 120                 125             


Pro Val Glu Gly Val Ser Ala Ser Gln Ala Thr Gln Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Asp Pro Val Arg Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Ser Thr Phe Phe His Tyr Thr Asn Asp Thr Glu Pro Lys Met 
                165                 170                 175     


Arg Leu Val Ile Trp Leu Tyr Thr Pro Leu Arg Thr Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Ser Phe Thr Val Ser Gly Arg Ile Leu Thr Arg Pro Ser Gln 
        195                 200                 205             


Asp Phe Glu Phe Ala Phe Leu Ile Pro Pro Thr Val Glu Thr Lys Thr 
    210                 215                 220                 


Thr Pro Phe Ser Val Pro Gly Phe Ser Val Gln Glu Met Ser Asn Ser 
225                 230                 235                 240 


Arg Trp Pro Ala Ala Ile Ser Ala Met Val Val Arg Gly Asn Glu Pro 
                245                 250                 255     


Gln Val Val Gln Phe Gln Asn Gly Arg Ala His Leu Asp Gly Met Leu 
            260                 265                 270         


Leu Gly Thr Thr Pro Val Ser Pro Asn Tyr Ile Ala Ser Tyr Arg Gly 
        275                 280                 285             


Ile Ser Thr Gly Asn Ser Arg Ser Ala Ser Ser Glu Ala Asp Glu Arg 
    290                 295                 300                 


Ala Val Gly Ser Phe Asp Val Trp Val Arg Leu Gln Glu Pro Asp Gly 
305                 310                 315                 320 


Gln Pro Tyr Asp Ile Phe Gly Lys Gln Pro Ala Pro Ile Gly Thr Pro 
                325                 330                 335     


Asp Phe Lys Ala Val Ile Val Gly Phe Ala Ala Arg Pro Leu Thr Ser 
            340                 345                 350         


Gly Ser Tyr Ala Asn Glu Ala Tyr Val Asn Thr Thr Ala Ser Asp Tyr 
        355                 360                 365             


Ala Pro Ala Thr Gly Asn Met Arg Phe Thr Val Arg Asn Gly Gly Thr 
    370                 375                 380                 


Gly His Ile Ser Ala Asn Lys Tyr Trp Glu Phe Lys Ser Phe Gly Val 
385                 390                 395                 400 


Glu Gly Glu Arg His Thr Asp Ile Gln Tyr Gln Glu Tyr Glu Leu Pro 
                405                 410                 415     


Asp Tyr Ser Gly Gln Val Ala Ser Asn His Asn Leu Ala Pro Pro Val 
            420                 425                 430         


Ala Pro Arg Met Pro Gly Glu Ser Leu Leu Leu Phe Gln Ser Asn Met 
        435                 440                 445             


Pro Val Trp Asp Asp Gly His Gly Glu Ser Thr Pro Lys Lys Ile His 
    450                 455                 460                 


Cys Leu Leu Pro Gln Glu Phe Ile Gly His Phe Phe Asp Arg Gln Ala 
465                 470                 475                 480 


Pro Ser Leu Gly Asp Ala Ala Leu Leu Arg Tyr Val Asn Gln Glu Thr 
                485                 490                 495     


Asn Arg Val Leu Phe Glu Cys Lys Leu Tyr Arg Asp Gly Tyr Ile Thr 
            500                 505                 510         


Val Ala Ala Ser Ser Gly Leu Leu Asp Phe Pro Leu Asp Gly Phe Phe 
        515                 520                 525             


Arg Phe Asp Ser Trp Val Ser Ser Phe Tyr Ile Leu Ser Pro Val Gly 
    530                 535                 540                 


Ser Gly Gln Gly Arg Arg Gly Arg Val Arg Phe Gln 
545                 550                 555     


<210>  56
<211>  554
<212>  PRT
<213>  Norovirus

<400>  56

Met Lys Met Ala Ser Asn Asp Ala Pro Pro Ser Ser Asp Gly Ala Gly 
1               5                   10                  15      


Asn Leu Val Pro Glu Ser His Gln Glu Val Leu Pro Leu Ala Pro Val 
            20                  25                  30          


Ala Gly Ala Glu Leu Ala Ala Pro Val Val Gly Gln Thr Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Lys Glu Asn Phe Val Gln Ala Pro Gln Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Lys Asn Ala Pro Gly Glu Ile Leu Val Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Asn Leu Asn Pro Tyr Leu Glu His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Ala Tyr Ala Gly Gly Ile Glu Val Glu Ile Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Ile Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Val Glu Ser Val Ser Ala Ser Gln Ala Thr Gln Phe Pro His Ala 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Leu Glu Pro Val Arg Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Ser Asn Phe Phe His Tyr Thr Thr Lys Asp Glu Pro Lys Met 
                165                 170                 175     


Arg Leu Val Ile Trp Leu Tyr Thr Pro Leu Arg Thr Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Ser Phe Thr Val Ser Gly Arg Leu Leu Thr Arg Pro Ser Met 
        195                 200                 205             


Asp Phe Gln Phe Ser Phe Leu Val Pro Pro Thr Val Glu Thr Lys Thr 
    210                 215                 220                 


Val Leu Phe Thr Val Pro Gly Leu Thr Pro Gln Glu Met Ser Asn Ser 
225                 230                 235                 240 


Arg Trp Pro Ala Gln Ile Ser Gly Met Val Val Arg Gly Asn Glu Pro 
                245                 250                 255     


Gln Val Val Gln Phe Gln Asn Gly Arg Cys His Thr Asp Gly Thr Leu 
            260                 265                 270         


Leu Gly Thr Thr Thr Val Ser Glu Gln Cys Ile Ala Gly Phe Val Gly 
        275                 280                 285             


Thr Ser Thr Asn Thr Arg Ser Ala Thr Gly Ser Thr Thr Glu Thr Arg 
    290                 295                 300                 


Thr Gly Asp Thr Asp Leu Trp Leu Arg Leu Glu Glu Pro Asn Gly Gln 
305                 310                 315                 320 


Pro Tyr Asp Ile Phe Gly Asp Gln Pro Ala Pro Leu Gly Thr Pro Asp 
                325                 330                 335     


Phe Arg Ala Val Ile Val Gly Phe Ala Ser Arg Pro Gln Thr Gln Gly 
            340                 345                 350         


Ser Tyr Met Asn Glu Ala Tyr Val Asn Thr Val Asp Ser His Phe Ala 
        355                 360                 365             


Pro Ala Thr Gly Asn Thr Lys Ile Ile Leu Arg Arg Gly Gly Thr Gly 
    370                 375                 380                 


His Val Gly Gly Gly His Leu Trp Lys Phe Arg Pro Phe Gly Val Glu 
385                 390                 395                 400 


Gly Gly Glu Gly Arg Val Ser Tyr Gln Glu Tyr Val Leu Pro Asn Tyr 
                405                 410                 415     


Ser Gly Ala Thr Ala Ser Asn His Asn Leu Ala Pro Pro Val Ala Pro 
            420                 425                 430         


Arg Met Pro Gly Glu Leu Leu Leu Leu Phe Glu Ser Asp Met Pro Val 
        435                 440                 445             


Trp Asp Asp Gly His Gly Ala Ala Pro Ala Gln Lys Ile His Cys Leu 
    450                 455                 460                 


Leu Pro Gln Gln Phe Ile Thr His Phe Phe Asp Ser Gln Ala Pro Ala 
465                 470                 475                 480 


Leu Ala Glu Ala Ala Leu Leu Arg Tyr Val His Pro Asp Ser Ser Arg 
                485                 490                 495     


Val Leu Phe Glu Thr Lys Leu Tyr Arg Glu Gly Phe Met Val Val Ser 
            500                 505                 510         


Ala Pro Thr Gly Arg Phe Asp Phe Pro Leu Asp Gly Tyr Phe Arg Phe 
        515                 520                 525             


Asp Ser Trp Val Asn Ser Phe Tyr Val Leu Ser Pro Val Gly Ser Gly 
    530                 535                 540                 


Gln Gly Arg Arg Gly Arg Ser Lys Val Val 
545                 550                 


<210>  57
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  sequence stretch with variant amino acid residue


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Leu or Val

<400>  57

Ala Ala Leu Xaa His Tyr 
1               5       


<210>  58
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence stretch with variant amino acid residue


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Leu or Val

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Arg or Lys

<400>  58

Ala Ala Leu Xaa Xaa Tyr 
1               5       


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence stretch with variant amino acid residue


<220>
<221>  variant
<222>  (4)..(4)
<223>  Leu or Val

<220>
<221>  variant
<222>  (7)..(7)
<223>  Val, Leu or Ile

<400>  59

Ala Ala Leu Xaa His Tyr Xaa Asp 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence stretch with variant amino acid residue


<220>
<221>  variant
<222>  (4)..(4)
<223>  Leu or Val

<220>
<221>  variant
<222>  (5)..(5)
<223>  Arg or Lys

<220>
<221>  variant
<222>  (7)..(7)
<223>  Val or Leu or Ile

<400>  60

Ala Ala Leu Xaa Xaa Tyr Xaa Asp 
1               5               


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence stretch with variant amino acid residue


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Leu or Val

<400>  61

Ala Ala Leu Xaa His 
1               5   


