                         SEQUENCE LISTING

<110>  Klinikum der Universitt Mnchen
 
<120>  CCR8 Expressing Lymphocytes for Targeted Tumor Therapy

<130>  AB2539 PCT S3

<150>  19 16 1708.3
<151>  2019-03-08

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  2
<211>  1068
<212>  DNA
<213>  Homo sapiens

<400>  2
atggattata cacttgacct cagtgtgaca acagtgaccg actactacta ccctgatatc       60

ttctcaagcc cctgtgatgc ggaacttatt cagacaaatg gcaagttgct ccttgctgtc      120

ttttattgcc tcctgtttgt attcagtctt ctgggaaaca gcctggtcat cctggtcctt      180

gtggtctgca agaagctgag gagcatcaca gatgtatacc tcttgaacct ggccctgtct      240

gacctgcttt ttgtcttctc cttccccttt cagacctact atctgctgga ccagtgggtg      300

tttgggactg taatgtgcaa agtggtgtct ggcttttatt acattggctt ctacagcagc      360

atgtttttca tcaccctcat gagtgtggac aggtacctgg ctgttgtcca tgccgtgtat      420

gccctaaagg tgaggacgat caggatgggc acaacgctgt gcctggcagt atggctaacc      480

gccattatgg ctaccatccc attgctagtg ttttaccaag tggcctctga agatggtgtt      540

ctacagtgtt attcatttta caatcaacag actttgaagt ggaagatctt caccaacttc      600

aaaatgaaca ttttaggctt gttgatccca ttcaccatct ttatgttctg ctacattaaa      660

atcctgcacc agctgaagag gtgtcaaaac cacaacaaga ccaaggccat caggttggtg      720

ctcattgtgg tcattgcatc tttacttttc tgggtcccat tcaacgtggt tcttttcctc      780

acttccttgc acagtatgca catcttggat ggatgtagca taagccaaca gctgacttat      840

gccacccatg tcacagaaat catttccttt actcactgct gtgtgaaccc tgttatctat      900

gcttttgttg gggagaagtt caagaaacac ctctcagaaa tatttcagaa aagttgcagc      960

caaatcttca actacctagg aagacaaatg cctagggaga gctgtgaaaa gtcatcatcc     1020

tgccagcagc actcctcccg ttcctccagc gtagactaca ttttgtaa                  1068


<210>  3
<211>  353
<212>  PRT
<213>  Mus musculus

<400>  3

Met Asp Tyr Thr Met Glu Pro Asn Val Thr Met Thr Asp Tyr Tyr Pro 
1               5                   10                  15      


Asp Phe Phe Thr Ala Pro Cys Asp Ala Glu Phe Leu Leu Arg Gly Ser 
            20                  25                  30          


Met Leu Tyr Leu Ala Ile Leu Tyr Cys Val Leu Phe Val Leu Gly Leu 
        35                  40                  45              


Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Gly Cys Lys Lys Leu 
    50                  55                  60                  


Arg Ser Ile Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ala Ser Asp Leu 
65                  70                  75                  80  


Leu Phe Val Leu Ser Ile Pro Phe Gln Thr His Asn Leu Leu Asp Gln 
                85                  90                  95      


Trp Val Phe Gly Thr Ala Met Cys Lys Val Val Ser Gly Leu Tyr Tyr 
            100                 105                 110         


Ile Gly Phe Phe Ser Ser Met Phe Phe Ile Thr Leu Met Ser Val Asp 
        115                 120                 125             


Arg Tyr Leu Ala Ile Val His Ala Val Tyr Ala Ile Lys Val Arg Thr 
    130                 135                 140                 


Ala Ser Val Gly Thr Ala Leu Ser Leu Thr Val Trp Leu Ala Ala Val 
145                 150                 155                 160 


Thr Ala Thr Ile Pro Leu Met Val Phe Tyr Gln Val Ala Ser Glu Asp 
                165                 170                 175     


Gly Met Leu Gln Cys Phe Gln Phe Tyr Glu Glu Gln Ser Leu Arg Trp 
            180                 185                 190         


Lys Leu Phe Thr His Phe Glu Ile Asn Ala Leu Gly Leu Leu Leu Pro 
        195                 200                 205             


Phe Ala Ile Leu Leu Phe Cys Tyr Val Arg Ile Leu Gln Gln Leu Arg 
    210                 215                 220                 


Gly Cys Leu Asn His Asn Arg Thr Arg Ala Ile Lys Leu Val Leu Thr 
225                 230                 235                 240 


Val Val Ile Val Ser Leu Leu Phe Trp Val Pro Phe Asn Val Ala Leu 
                245                 250                 255     


Phe Leu Thr Ser Leu His Asp Leu His Ile Leu Asp Gly Cys Ala Thr 
            260                 265                 270         


Arg Gln Arg Leu Ala Leu Ala Ile His Val Thr Glu Val Ile Ser Phe 
        275                 280                 285             


Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Ile Gly Glu Lys 
    290                 295                 300                 


Phe Lys Lys His Leu Met Asp Val Phe Gln Lys Ser Cys Ser His Ile 
305                 310                 315                 320 


Phe Leu Tyr Leu Gly Arg Gln Met Pro Val Gly Ala Leu Glu Arg Gln 
                325                 330                 335     


Leu Ser Ser Asn Gln Arg Ser Ser His Ser Ser Thr Leu Asp Asp Ile 
            340                 345                 350         


Leu 
    


<210>  4
<211>  1062
<212>  DNA
<213>  Mus musculus

<400>  4
atggattaca cgatggagcc caacgtcacg atgaccgact actaccctga tttcttcacc       60

gccccctgtg acgcagagtt cctcctcagg ggcagcatgc tgtatctggc catcttgtac      120

tgcgtcttgt ttgtgctggg ccttctgggg aacagcctgg tcatcttagt cctcgtgggc      180

tgcaagaaac tgaggagcat cacagatatc tacctcctga acctggccgc atccgacctg      240

ctctttgtcc tctctattcc ttttcagacc cacaacctgc tggaccagtg ggtgtttggg      300

actgcgatgt gtaaggtggt ctctggcctt tattacattg gttttttcag cagtatgttc      360

ttcatcaccc taatgagtgt ggacaggtat ctggctattg tccacgctgt ctatgccatc      420

aaggtgagga cggccagcgt gggcacagcc ctgagtctga cagtgtggct ggctgctgtc      480

acagccacca tccccttgat ggttttttac caagtggcct ctgaagacgg catgctacaa      540

tgtttccagt tttatgaaga gcagtctttg aggtggaagc tctttaccca ctttgaaatc      600

aacgccttgg gtctgctgct cccctttgcc atcctcctgt tctgctatgt caggatcctg      660

cagcagctgc ggggctgcct gaaccacaac aggaccagag ccatcaagct ggtgctcacc      720

gtagtcattg tgtctttact cttctgggtc ccattcaacg tggccctttt cctcacgtcc      780

ctgcacgacc tgcacatctt ggatggatgt gccacgaggc agaggctggc tctggccatc      840

catgtcacag aggtcatctc ttttacccac tgctgcgtga accccgtcat ctacgcgttc      900

ataggagaga agtttaagaa acacctcatg gatgtgtttc aaaagagctg cagccacatc      960

ttcctctact tagggagaca aatgcccgtg ggggcgttgg aaaggcagct gtcctcgaac     1020

cagcgatctt cccattcttc caccctggat gacatcttgt aa                        1062


<210>  5
<211>  1557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-EpCAM CAR

<400>  5
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc tgaggtgcag ctggccgaat ctggcggcgg actggtgcag      120

cccggcagat ccatgaagct gagctgcgct gccagcggct tcaccttcag caacttcccc      180

atggcctggg tgcgccaggc ccccaccaag tgtctggaat gggtggccac catcagcacc      240

agcggcggca gcacctacta ccgggacagc gtgaagggcc ggttcaccat cagccgggac      300

aacgccaaga gcaccctgta cctgcagatg aacagcctgc ggagcgagga caccgccacc      360

tactactgca cccggaccct gtacatcctg cgggtgttct acttcgacta ctggggccag      420

ggcgtgatgg tgacagtgtc tagcggcgga ggcggcagcg gaggtggagg aagtggcggc      480

ggaggatccg acatccagat gacccagtct cccgccagcc tgagcgcctc tctgggcgag      540

acagtgtcca tcgagtgcct ggccagcgag ggcatcagca acgacctggc ctggtatcag      600

cagaagtccg gcaagagccc ccagctgctg atctacgcca ccagcagact gcaggacggc      660

gtgcccagca gattcagcgg cagcggctcc ggcacccggt acagcctgaa gatcagcggc      720

atgcagcccg aggacgaggc cgactacttc tgccagcaga gctacaagta cccctggacc      780

ttcggctgcg gcacaaagct ggaactgaag ggcggagggg gctctggggg aggcggatct      840

ctcgaggaac agaagctgat cagcgaagag gacctgacta ctaccaagcc agtgctgcga      900

actccctcac ctgtgcaccc taccgggaca tctcagcccc agagaccaga agattgtcgg      960

ccccgtggct cagtgaaggg gaccggattg gacttcgcct gtgatattta cttttgggca     1020

ctggtcgtgg ttgctggagt cctgttttgt tatggcttgc tagtgacagt ggctctttgt     1080

gttatctgga caaatagtag aaggaacaga ctccttcaaa gtgactacat gaacatgact     1140

ccccggaggc ctgggctcac tcgaaagcct taccagccct acgcccctgc cagagacttt     1200

gcagcgtacc gccccagagc aaaattcagc aggagtgcag agactgctgc caacctgcag     1260

gaccccaacc agctctacaa tgagctcaat ctagggcgaa gagaggaata tgacgtcttg     1320

gagaagaagc gggctcggga tccagagatg ggaggcaaac agcagaggag gaggaacccc     1380

caggaaggcg tatacaatgc actgcagaaa gacaagatgg cagaagccta cagtgagatc     1440

ggcacaaaag gcgagaggcg gagaggcaag gggcacgatg gcctttacca gggtctcagc     1500

actgccacca aggacaccta tgatgccctg catatgcaga ccctggcccc tcgctaa        1557


<210>  6
<211>  627
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dominant-negative TGF-B receptor 2

<400>  6
gccaccatgg gtcgggggct gctcaggggc ctgtggccgc tgcacatcgt cctgtggacg       60

cgtatcgcca gcacgatccc accgtatgat gttcctgatt atgctagcct ccacgttcag      120

aagtcggtta ataacgacat gatagtcact gacaacaacg gtgcagtcaa gtttccacaa      180

ctgtgtaaat tttgtgatgt gagattttcc acctgtgaca accagaaatc ctgcatgagc      240

aactgcagca tcacctccat ctgtgagaag ccacaggaag tctgtgtggc tgtatggaga      300

aagaatgacg agaacataac gctagagaca gtttgccatg accccaagct cccctaccat      360

gactttattc tggaagatgc tgcttctcca aagtgcatta tgaaggaaaa aaaaaagcct      420

ggtgagactt tcttcatgtg ttcctgtagc tctgatgagt gcaatgacaa catcatcttc      480

tcagaagaat ataacaccag caatcctgac ttgttgctag tcatatttca agtgacaggc      540

atcagcctcc tgccaccact gggagttgcc atatctgtca tcatcatctt ctactgctac      600

cgcgttaacc ggcagcagaa gctgtag                                          627


