                         SEQUENCE LISTING

<110>  NUVOBIO CORPORATION
 
<120>  PEPTIDE-DERIVED THERAPEUTICS TARGETING SET8 FOR THE TREATMENT OF 
       CANCER

<130>  3810-103PCT

<150>  62/818,251
<151>  2019-03-14

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  1

Thr His His His Lys His Pro His Ala 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  petide binding to SET8

<400>  2

Thr His His His Lys His Pro His His 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  3

Thr His His His Lys His Pro Lys His 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  4

Thr His His His Lys His Pro His Thr 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  5

Thr His His His Lys His Pro Lys Thr 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  6

Thr His His His Lys His Pro His Lys 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  7

Thr His His His Lys His Pro Glu Gln 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  8

Thr His His His Lys His Pro His Gln 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  9

Ser His His His Lys His Pro Lys Ala 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  10

Thr His His His Lys His Pro His Glu 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  11

Thr His His His Lys His Pro Gly Thr 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  12

Thr His His His Lys His Pro Glu Gly 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  13

Thr His His His Lys His Pro Gly His 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  14

Thr His His His Lys His Pro His Gly 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  15

Thr His His His Lys His Pro Lys Ala 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  16

Thr His His His Lys His Pro Gly Lys 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  17

Thr His His His Lys His Pro Lys Lys 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  18

Thr His His His Lys His Pro Gly Gly 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  19

Thr His His His Lys His Pro Gly Gln 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  20

Ser His His His Lys His Pro Gly Thr 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  21

Thr His His His Lys His Pro Gly Arg 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  22

Thr His His His Lys His Pro Gly Ala 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  23

Thr His His His Lys His Pro Gly Glu 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  24

Ser His His His Lys His Pro His Gly 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8

<400>  25

Ser His His His Lys His Pro Gly His 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  26

Thr His His His Xaa His Pro His Ala 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  27

Thr His His His Xaa His Pro His His 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  28

Thr His His His Xaa His Pro Lys His 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  29

Thr His His His Xaa His Pro His Thr 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  30

Thr His His His Xaa His Pro Lys Thr 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  31

Thr His His His Xaa His Pro His Lys 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  32

Thr His His His Xaa His Pro Glu Gln 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  33

Thr His His His Xaa His Pro His Gln 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  34

Ser His His His Xaa His Pro Lys Ala 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  35

Thr His His His Xaa His Pro His Glu 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  36

Thr His His His Xaa His Pro Gly Thr 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  37

Thr His His His Xaa His Pro Glu Gly 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  38

Thr His His His Xaa His Pro Gly His 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  39

Thr His His His Xaa His Pro His Gly 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  40

Thr His His His Xaa His Pro Lys Ala 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  41

Thr His His His Xaa His Pro Lys Ala 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  42

Thr His His His Xaa His Pro Lys Lys 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  43

Thr His His His Xaa His Pro Gly Gly 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  44

Thr His His His Xaa His Pro Gly Gln 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  45

Ser His His His Xaa His Pro Gly Thr 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  46

Thr His His His Xaa His Pro Gly Arg 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  47

Thr His His His Xaa His Pro Gly Ala 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  48

Thr His His His Xaa His Pro Gly Glu 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  49

Ser His His His Xaa His Pro His Gly 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide binding to SET8


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  norLeucine (Nle)

<400>  50

Ser His His His Xaa His Pro Gly His 
1               5                   


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT48-60

<400>  51

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT49-57

<400>  52

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Penetratin, pAntp(43-58)

<400>  53

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  54
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPV1047

<400>  54

Val Lys Arg Gly Leu Lys Leu Arg His Val Arg Pro Arg Val Thr Arg 
1               5                   10                  15      


Met Asp Val 
            


<210>  55
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR9

<400>  55

Phe Phe Leu Ile Pro Lys Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mut6DPT (CPP)

<400>  56

Arg Arg Trp Arg Arg Trp Arg Arg Trp Arg Arg 
1               5                   10      


<210>  57
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MPG

<400>  57

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  58
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pep-1

<400>  58

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  59
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pVEC

<400>  59

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  60
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARF(1-22)

<400>  60

Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210>  61
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPrPr(1-28)

<400>  61

Met Val Lys Ser Lys Ile Gly Ser Trp Ile Leu Val Leu Phe Val Ala 
1               5                   10                  15      


Met Trp Ser Asp Val Gly Leu Cys Lys Lys Arg Pro 
            20                  25              


<210>  62
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAP

<400>  62

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  63
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transportan

<400>  63

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  64
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p28

<400>  64

Leu Ser Thr Ala Ala Asp Met Gln Gly Val Val Thr Asp Gly Met Ala 
1               5                   10                  15      


Ser Gly Leu Asp Lys Asp Tyr Leu Lys Pro Asp Asp 
            20                  25              


<210>  65
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VT5

<400>  65

Asp Pro Lys Gly Asp Pro Lys Gly Val Thr Val Thr Val Thr Val Thr 
1               5                   10                  15      


Val Thr Gly Lys Gly Asp Pro Lys Pro Asp 
            20                  25      


<210>  66
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bac 7 (Bac 1-24)

<400>  66

Arg Arg Ile Arg Pro Arg Pro Pro Arg Leu Pro Arg Pro Arg Pro Arg 
1               5                   10                  15      


Pro Leu Pro Phe Pro Arg Pro Gly 
            20                  


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C105Y

<400>  67

Cys Ser Ile Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Tyr Leu 
1               5                   10                  15      


Ile 
    


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFVYLI

<400>  68

Pro Phe Val Tyr Leu Ile 
1               5       


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pep-7

<400>  69

Ser Asp Leu Trp Glu Met Met Met Val Ser Leu Ala Cys Gln Tyr 
1               5                   10                  15  


<210>  70
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Set8

<400>  70

Ala Ala Ile Ala Lys Gln Ala Leu Lys Lys Pro Ile Lys Gly Lys Gln 
1               5                   10                  15      


Ala Pro Arg Lys Lys Ala Gln Gly Lys Thr Gln Gln Asn Arg Lys Leu 
            20                  25                  30          


Thr Asp Phe Tyr Pro Val Arg Arg Ser Ser Arg Lys Ser Lys Ala Glu 
        35                  40                  45              


Leu Gln Ser Glu Glu Arg Lys Arg Ile Asp Glu Leu Ile Glu Ser Gly 
    50                  55                  60                  


Lys Glu Glu Gly Met Lys Ile Asp Leu Ile Asp Gly Lys Gly Arg Gly 
65                  70                  75                  80  


Val Ile Ala Thr Lys Gln Phe Ser Arg Gly Asp Phe Val Val Glu Tyr 
                85                  90                  95      


His Gly Asp Leu Ile Glu Ile Thr Asp Ala Lys Lys Arg Glu Ala Leu 
            100                 105                 110         


Tyr Ala Gln Asp Pro Ser Thr Gly Cys Tyr Met Tyr Tyr Phe Gln Tyr 
        115                 120                 125             


Leu Ser Lys Thr Tyr Cys Val Asp Ala Thr Arg Glu Thr Asn Arg Leu 
    130                 135                 140                 


Gly Arg Leu Ile Asn His Ser Lys Cys Gly Asn Cys Gln Thr Lys Leu 
145                 150                 155                 160 


His Asp 
        


<210>  71
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence for SET8 binding peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Thr or Ser

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Lys or Nle

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Gly, His or Glu

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Gln, Lys, Gly, Arg, Ala, Thr or Glu

<400>  71

Xaa His His His Xaa His Pro Xaa Xaa 
1               5              

<210>  72
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide binding SET8


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  any amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Arg, His, Glu, Asp, Gln or Lys

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  His or Glu

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Pro, Asn, Gln, Ile, Arg or Glu

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Met, Asn, Glu, Asp, Gln, Pro, Phe, Trp, Lys, Ile, Gly or Val

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  72

Xaa His His His Xaa Xaa Xaa Xaa Xaa 
1               5                   


     



