                         SEQUENCE LISTING

<110>  Children's Medical Center Corporation
       Massachusetts Institute of Technology
 
<120>  TARGETED DELIVERY OF IMMUNE-MODULATING VHH AND VHH-FUSION PROTEIN

<130>  C1233.70162WO00

<140>  PCT/US2020/021466
<141>  2020-03-06

<150>  US 62/815,318
<151>  2019-03-07

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Lys Ile Asn 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Trp Val 
        35                  40                  45              


Ala Ala Ser Thr Gly Gly Asp Glu Ala Ile Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  


Asp Arg Phe Thr Ile Ser Arg Asp Ala Lys Asn Ser Val Phe Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ala 
                85                  90                  95      


Val Ile Ser Thr Asp Arg Asp Gly Thr Glu Trp Arg Arg Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Thr Phe Ser Arg Asn 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Arg Thr Gly Thr Asn Ser Tyr Asp Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Ser Gln Thr Ala Ser Val Ala Thr Thr Glu Arg Leu Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  3
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser His Asn 
            20                  25                  30          


Ala Gly Gly Trp Tyr Arg Gln Ala Pro Glu Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Ser Ser Asp Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Ser Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Asn 
                85                  90                  95      


Ile Arg Gly Ser Tyr Gly Asn Thr Tyr Tyr Ser Arg Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Ser Ser Val 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Thr Pro Gly Asn Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Thr Ser Ser Thr Ser Ser Thr Thr Ala Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Thr Gly Leu Thr Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  5
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Met His 
            20                  25                  30          


Ala Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Thr Ser His Gly Asp Arg Ala Asn Tyr Thr Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Val Pro Arg Tyr Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  6
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Thr Phe Phe Gly Cys Ser Leu Asn Arg Asp Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  7
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Gly Ser Ser Tyr 
            20                  25                  30          


Ile Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Val Ser Pro Ser Gly Gly Thr Arg Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Arg Leu Lys Pro Glu Asp Thr Ala Ile Tyr Thr Cys 
                85                  90                  95      


Ala Ala Ala Gly Gly Lys Trp Thr Ala Asp Ser Gly Glu Tyr Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  8
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Gly 
            20                  25                  30          


Val Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ile Phe Ser Gly Ser Ser Trp Ser Gly Arg Ser Thr Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Gly Tyr Pro Glu Ala Tyr Ser Ala Tyr Gly Arg 
            100                 105                 110         


Glu Ser Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  9
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Arg Tyr 
            20                  25                  30          


Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  10
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Gln Val Gln Leu His Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Leu Asp His Ser 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Lys Leu 
        35                  40                  45              


Leu Cys Ile Asn Ala Asn Gly Val Ser Leu Asp Tyr Ala Asp Ser Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Thr Tyr Ser Cys 
                85                  90                  95      


Ala Ala Thr Arg Glu Phe Cys Ser Ala Tyr Val Phe Leu Tyr Glu His 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  11
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
caagtccagt tggtggagtc tggtggtggc cttgtggagc ctggtggcag cctgcgcctg       60

agctgtgccg ccagcgggat aattttcaag atcaacgata tgggttggta cagacaggcc      120

cccggcaaga gacgggaatg ggtagccgct agtactggcg gtgacgaggc tatatatcgc      180

gattctgtga aggatcggtt cactatctcc cgcgacgcca aaaattccgt cttcctgcag      240

atgaatagct tgaaacctga ggacacagcg gtttactact gtaccgccgt gatttctacc      300

gacagggacg gcactgaatg gcggcgctac tggggccaag ggacgcaggt cacggtgtcc      360

agc                                                                    363


<210>  12
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
caagtgcagc ttgtcgaatc cggcggcggc ctcgtgcagg ctggaggcag cctccgattg       60

agctgcactg cttcagggag taccttctca cggaatgcaa tggcctggtt caggcaggcc      120

cctggcaagg aacgcgaatt tgtctctggt atcagccgga cgggtacaaa ctcctatgat      180

gctgatagtg taaagggtcg gttcacgatt tccaaggaca acgcaaaaaa cactgtgact      240

cttcaaatga actcactgaa gccggaggac accgccatat attattgtgc cttgagtcag      300

acggccagcg tggccaccac agagcgactc tatccctact ggggccaggg aacacaggtg      360

actgtgtcta gt                                                          372


<210>  13
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
caggtgcagc tcgtggagac tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag cacattcagt cataatgccg gcggctggta ccgccaggct      120

ccagaaaagc agcgcgagtt ggtcgcaggg attagtagtg atggtaacat caactatgcg      180

gactccgtga aggaccgatt caccatctcc agagacaacg ccagcaacac gatgtatcta      240

caaatgaaca acctgaaacc tgaggacacg gccgtctatg tctgtaatat caggggatcg      300

tacggtaata cctattacag tcggtggggc caggggaccc aggtcaccgt ctcctca         357


<210>  14
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
caggtgcagc tgcaggagtc tggaggaggg ttggcgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag cacgatcagt agcgtcgccg tgggctggta ccgccagact      120

ccagggaatc agcgcgagtg ggtcgccact agtagcacga gtagtactac cgcaacgtat      180

gctgactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgatctat      240

ctgcaaatga acagcctgaa acctgaggac acggccgtct attactgtaa aacaggcctg      300

actaattggg gccaggggac ccaggtcacc gtctcctca                             339


<210>  15
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
caggtgcagc tgcaggagtc ggggggaggc ttggtgcagc ctggggggtc tctgagactt       60

tcctgtacag cctctggatt caccttcagt atgcatgcca tgacctggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcagtt attactagtc atggtgatag ggcaaactat      180

acagactccg tgaggggccg attcaccatc tccagagaca ataccaagaa catggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgtgt attattgtaa tgtcccccgg      300

tatgactcct ggggccaggg gacccaggtc accgtctcct ca                         342


<210>  16
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
caggtgcagc tcgtggagtc ggggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttcgat gattatgcca taggctggtt ccgccaggcc      120

ccagggaagg agcgtgaggg ggtctcatgt attagtagta gtgatggtag cacatactat      180

acagactccg tgaagggccg attcaccatc tccagtgaca acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agcggacacc      300

actttcttcg gctgctctct gaaccgggac tatgactact ggggccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  17
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
caggtgcagc tcgtggagtc gggtggaggt atggtgcaac ctggggactc tctgaggctc       60

tcctgtgtag cctctggacg caccggcagt agctatatca taggctggtt ccgccaggct      120

ccaggaaagg agcgtgagtt tgtagcgcgt gtttcaccga gcggcggtac cagagactat      180

gcagactccg tgaagggacg attcaccgtc tccagagaca acgccaaaaa cacggtgtac      240

ctgcaaatgg acaggctgaa acctgaagac acggccattt atacctgtgc tgcggctggg      300

gggaaatgga cagcggattc gggagagtat aactactggg gccaggggac ccaggtcacc      360

gtctcctca                                                              369


<210>  18
<211>  383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
caggtgcagc tgcaggagtc agggggagga ttggtgcagg ctggggactc tctgagactc       60

tcctgcgcag cctctggacg caccttcagt cgcggtgtaa tgggctggtt ccgccgggct      120

ccagggaagg agcgtgagtt tgtagcaatc tttagcggga gtagctggag tggtcgtagt      180

acatactatt cagactccgt aaagggccga ttcaccatct ccagagacaa cgccaagaac      240

acggtgtatc tgcaaatgaa cggcctgaaa cctgaggaca cggccgttta ttactgtgca      300

gcgggatatc cggaggcgta tagcgcctat ggtcgggaga gtacatatga ctactggggc      360

caggggaccc aggtcaccgt ctc                                              383


<210>  19
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
caggtgcagc tgcaggaatc gggtggtgcc ctggttcagc cgggtggtag cctgcgtctg       60

tcgtgtgctg cgtcgggttt tccggttaac cgttatagca tgcgttggta ccgtcaggca      120

ccgggtaaag aacgtgaatg ggtcgcgggc atgagctctg ccggtgatcg tagttcctat      180

gaagactcag tgaaaggtcg ctttaccatt tcgcgtgatg acgcacgcaa cacggtgtac      240

ctgcaaatga atagtctgaa accggaagat accgctgttt attactgtaa tgttaatgtc      300

ggctttgaat actggggtca gggcacgcag gtcaccgtct cctca                      345


<210>  20
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
caggtgcagc tgcatgagtc agggggagga ttggtgcagc ctggggagtc tctgagactt       60

tcctgcgtag cctctggatt cactctggat cattctgccg tcggctggtt ccgccaggtc      120

cccgggaagg agcgtgagaa actcttgtgc attaacgcta acggtgttag cctggactat      180

gcagactcca ttaagggccg attcaccatc tctcgggaca acgccaagaa cacggtctat      240

ctgcagatga acgacctgaa acctgaggac acagccacat atagctgtgc agcaacgaga      300

gaattctgtt cagcttatgt gttcctatat gaacactggg gccaggggac ccaggtcacc      360

gtctcctca                                                              369


<210>  21
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        35                  40                  45              


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Val Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Pro Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  25
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  26
<211>  573
<212>  DNA
<213>  Unknown

<220>
<223>  Encephalomyocarditis virus IRES Sequence

<400>  26
cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg       60

tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg      120

gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg      180

aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca      240

aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgcct      300

ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca      360

cgttgtgagt tggatagttg tggaaagagt caaatggctc acctcaagcg tattcaacaa      420

ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggtg      480

cacatgcttt acatgtgttt agtcgaggtt aaaaaacgtc taggcccccc gaaccacggg      540

gacgtggttt tcctttgaaa aacacgatga taa                                   573


