                         SEQUENCE LISTING

<110>  MIRAGEN THERAPEUTICS, INC.
 
<120>  MICRORNA MIMICS AND USES THEREOF

<130>  MIRG-056/01WO

<140>  US 62/814,224
<141>  2019-03-05

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M12978

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-adenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Three GalNac conjugates linked via phosphorothioate bonds

<400>  1
aacacuguuu acaaaugguc cua                                               23


<210>  2
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M12979

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-adenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Three GalNac conjugates linked via phosphorothioate bonds

<400>  2
aacacuguuu acaaaugguc cua                                               23


<210>  3
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M12971

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-adenosine

<400>  3
aacacuguuu acaaaugguc cua                                               23


<210>  4
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M12972

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-adenosine

<400>  4
aacacuguuu acaaaugguc cua                                               23


<210>  5
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13008

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-adenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Three GalNac conjugates linked via phosphorothioate bonds

<400>  5
aacacuguuu acaaaugguc cua                                               23


<210>  6
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13010

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-adenosine

<400>  6
aacacuguuu acaaaugguc cua                                               23


<210>  7
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13012

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-adenosine

<400>  7
aacacuguuu acaaaugguc cua                                               23


<210>  8
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13014

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  deoxyadenosine

<400>  8
aacacuguuu acaaaugguc cua                                               23


<210>  9
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13016

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-cytidine

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  joined through a phosphorothioate bond

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  deoxyadenosine

<400>  9
aacacuguuu acaaaugguc cua                                               23


<210>  10
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13018

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-cytidine

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  joined through a phosphorothioate bond

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  deoxyadenosine

<400>  10
aacacuguuu acaaaugguc cua                                               23


<210>  11
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13041

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-adenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Cholesterol conjugate with a 6 carbon linker

<400>  11
aacacuguuu acaaaugguc cua                                               23


<210>  12
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13113

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-adenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Cholesterol conjugate with a 6 carbon linker linked via 
       phosphorothioate bond

<400>  12
aacacuguuu acaaaugguc cua                                               23


<210>  13
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M10456

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Cholesterol conjugate with a 6 carbon linker

<400>  13
aacacuguuu acaaaugguc cua                                               23


<210>  14
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M12211

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-uridine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Cholesterol conjugate with a 6 carbon linker

<400>  14
agugaaauca accagugcga ua                                                22


<210>  15
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M11931

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Cholesterol conjugate with a 6 carbon linker

<400>  15
agugugagau caaccauugc gaaa                                              24


<210>  16
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M11932

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-cytidine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Cholesterol conjugate with a 6 carbon linker

<400>  16
agcaaaauug agcuagugcg aaa                                               23


<210>  17
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M12974

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<400>  17
uagcaccauu ugaaaucagu guuuu                                             25


<210>  18
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13019

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  locked nucleic acid cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<400>  18
uagcaccauu ugaaaucagu guuuu                                             25


<210>  19
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13020

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  locked nucleic acid cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  locked nucleic acid thymidine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<400>  19
uagcaccauu ugaaancag uguuuu                                             25


<210>  20
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M11769

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-terminal monophosphate moiety linked

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  3' Fluorescein linked via phosphorothioate bond

<400>  20
uagcaccauu ugaaaucagu guuuu                                             25


<210>  21
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13121

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  3' Fluorescein linked via phosphorothioate bond

<400>  21
uagcaccauu ugaaaucagu guuuu                                             25


<210>  22
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M12210

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  misc_feature
<222>  (22)..(24)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<400>  22
uauggcacug guagaauuca cuuu                                              24


<210>  23
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M11681

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-cytidine

<220>
<221>  misc_feature
<222>  (24)..(26)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-fluoro-uridine

<400>  23
uuuggcaaug guagaacuca cacuuu                                            26


<210>  24
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M11679

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-cytidine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-uridine

<400>  24
uuuggcacua gcacauuuuu gcuuu                                             25


<210>  25
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13145

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Fluorescein linked via phosphorothioate bond

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-cytidine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-uridine

<400>  25
uuuggcacua gcacauuuuu gcuuu                                             25


<210>  26
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M12973

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<400>  26
uagcaccauu ugaaaucagu guuuu                                             25


<210>  27
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13009

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<400>  27
uagcaccauu ugaaaucagu guuuu                                             25


<210>  28
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13011

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<400>  28
uagcaccauu ugaaaucagu guuuu                                             25


<210>  29
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13013

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<400>  29
uagcaccauu ugaaaucagu guuuu                                             25


<210>  30
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13015

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  deoxythymidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  deoxythymidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<400>  30
uagcaccaun ngaaaucagu guuuu                                             25


<210>  31
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-29 mimic M13017

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  deoxythymidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  deoxythymidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  deoxyadenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  deoxyguanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<400>  31
uagcaccaun ngaaaucagu guuuu                                             25


<210>  32
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-96 mimic M13128

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-guanosine

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-adenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Cholesterol conjugate with a 6 carbon linker linked via 
       phosphorothioate bond 

<400>  32
agcaaaauug agcuagugcg aaa                                               23


<210>  33
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-182 mimic M13137

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-guanosine

<220>
<221>  misc_feature
<222>  (22)..(24)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-fluoro-adenosine

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Cholesterol conjugate with a 6 carbon linker linked via 
       phosphorothioate bond 

<400>  33
agugugagau caaccauugc gaaa                                              24


<210>  34
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-183 mimic M13143

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-guanosine

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-adenosine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Cholesterol conjugate with a 6 carbon linker linked via 
       phosphorothioate bond

<400>  34
agugaaauca accagugcga ua                                                22


<210>  35
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-96 mimic M11932

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-cytidine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Cholesterol conjugate with a 6 carbon linker linked via 
       phosphorothioate bond

<400>  35
agcaaaauug agcuagugcg aaa                                               23


<210>  36
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-182 mimic M11931

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl-cytidine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Cholesterol conjugate with a 6 carbon linker linked via 
       phosphorothioate bond

<400>  36
agugugagau caaccauugc gaaa                                              24


<210>  37
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-183 mimic M12211

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-uridine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Cholesterol conjugate with a 6 carbon linker linked via 
       phosphorothioate bond

<400>  37
agugaaauca accagugcga ua                                                22


<210>  38
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-96 mimic M13144

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Fluorescein linked via phosphorothioate bond

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-cytidine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<400>  38
uuuggcacua gcacauuuuu gcuuu                                             25


<210>  39
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-96 mimic M13127

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-cytidine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<400>  39
uuuggcacua gcacauuuuu gcuuu                                             25


<210>  40
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-96 mimic M11679

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-cytidine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-uridine

<400>  40
uuuggcacua gcacauuuuu gcuuu                                             25


<210>  41
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-96 mimic M13145

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Fluorescein linked via phosphorothioate bond

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-cytidine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-uridine

<400>  41
uuuggcacua gcacauuuuu gcuuu                                             25


<210>  42
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-182 mimic M13136

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-cytidine

<220>
<221>  misc_feature
<222>  (24)..(26)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl-uridine

<400>  42
uuuggcaaug guagaacuca cacuuu                                            26


<210>  43
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-182 mimic M11681

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-fluoro-cytidine

<220>
<221>  misc_feature
<222>  (24)..(26)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-fluoro-uridine

<400>  43
uuuggcaaug guagaacuca cacuuu                                            26


<210>  44
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-183 mimic M13142

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-guanosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro-guanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro-adenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-cytidine

<220>
<221>  misc_feature
<222>  (22)..(24)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl-uridine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl-uridine

<400>  44
uauggcacug guagaauuca cuuu                                              24


<210>  45
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  miR-183 mimic M12210

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro-uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluoro-cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-fluoro-cytidine

<220>
<221>  misc_feature
<222>  (22)..(24)
<223>  joined through phosphorothioate bonds

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-fluoro-uridine

<400>  45
uauggcacug guagaauuca cuuu                                              24


