                         SEQUENCE LISTING

<110>  Massachusetts Institute of Technology
 
<120>  DNA LAUNCHED RNA REPLICON SYSTEM (DREP) AND USES THEREOF

<130>  M0656.70458WO00

<140>  Not yet assigned
<141>  Concurrently herewith

<150>  US 62/813,979
<151>  2019-03-05

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt       60

ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat      120

cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg      180

gggaggattg ggaagagaat agcaggcatg ctggggatgc ggtgggctct atggc           235


<210>  2
<211>  541
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
tgaattcact cctcaggtgc aggctgccta tcagaaggtg gtggctggtg tggccaatgc       60

cctggctcac aaataccact gagatctttt tccctctgcc aaaaattatg gggacatcat      120

gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt      180

gtgttggaat tttttgtgtc tctcactcgg aaggacatat gggagggcaa atcatttaaa      240

acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc tggctgccat      300

gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg ctgtccattc      360

cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt gttttgtgtt      420

atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca gatttttcct      480

cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat ccctcgacct      540

g                                                                      541


<210>  3
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
agcggccgcc tgcagcttaa gaccggtaag ctaagctacg cgtgctagcg ggcccgttaa       60

cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa      120

taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta      180

tcatgtctgg atcttaatta a                                                201


<210>  4
<211>  1605
<212>  DNA
<213>  Venezuelan equine encephalitis virus

<400>  4
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc tcgtaacata ggcctatgca gctctgacgt tatggagcgg      660

tcacgtagag ggatgtccat tcttagaaag aagtatttga aaccatccaa caatgttcta      720

ttctctgttg gctcgaccat ctaccacgag aagagggact tactgaggag ctggcacctg      780

ccgtctgtat ttcacttacg tggcaagcaa aattacacat gtcggtgtga gactatagtt      840

agttgcgacg ggtacgtcgt taaaagaata gctatcagtc caggcctgta tgggaagcct      900

tcaggctatg ctgctacgat gcaccgcgag ggattcttgt gctgcaaagt gacagacaca      960

ttgaacgggg agagggtctc ttttcccgtg tgcacgtatg tgccagctac attgtgtgac     1020

caaatgactg gcatactggc aacagatgtc agtgcggacg acgcgcaaaa actgctggtt     1080

gggctcaacc agcgtatagt cgtcaacggt cgcacccaga gaaacaccaa taccatgaaa     1140

aattaccttt tgcccgtagt ggcccaggca tttgctaggt gggcaaagga atataaggaa     1200

gatcaagaag atgaaaggcc actaggacta cgagatagac agttagtcat ggggtgttgt     1260

tgggctttta gaaggcacaa gataacatct atttataagc gcccggatac ccaaaccatc     1320

atcaaagtga acagcgattt ccactcattc gtgctgccca ggataggcag taacacattg     1380

gagatcgggc tgagaacaag aatcaggaaa atgttagagg agcacaagga gccgtcacct     1440

ctcattaccg ccgaggacgt acaagaagct aagtgcgcag ccgatgaggc taaggaggtg     1500

cgtgaagccg aggagttgcg cgcagctcta ccacctttgg cagctgatgt tgaggagccc     1560

actctggaag ccgatgtcga cttgatgtta caagaggctg gggcc                     1605


<210>  5
<211>  2382
<212>  DNA
<213>  Venezuelan equine encephalitis virus

<400>  5
ggctcagtgg agacacctcg tggcttgata aaggttacca gctacgatgg cgaggacaag       60

atcggctctt acgctgtgct ttctccgcag gctgtactca agagtgaaaa attatcttgc      120

atccaccctc tcgctgaaca agtcatagtg ataacacact ctggccgaaa agggcgttat      180

gccgtggaac cataccatgg taaagtagtg gtgccagagg gacatgcaat acccgtccag      240

gactttcaag ctctgagtga aagtgccacc attgtgtaca acgaacgtga gttcgtaaac      300

aggtacctgc accatattgc cacacatgga ggagcgctga acactgatga agaatattac      360

aaaactgtca agcccagcga gcacgacggc gaatacctgt acgacatcga caggaaacag      420

tgcgtcaaga aagaactagt cactgggcta gggctcacag gcgagctggt ggatcctccc      480

ttccatgaat tcgcctacga gagtctgaga acacgaccag ccgctcctta ccaagtacca      540

accatagggg tgtatggcgt gccaggatca ggcaagtctg gcatcattaa aagcgcagtc      600

accaaaaaag atctagtggt gagcgccaag aaagaaaact gtgcagaaat tataagggac      660

gtcaagaaaa tgaaagggct ggacgtcaat gccagaactg tggactcagt gctcttgaat      720

ggatgcaaac accccgtaga gaccctgtat attgacgaag cttttgcttg tcatgcaggt      780

actctcagag cgctcatagc cattataaga cctaaaaagg cagtgctctg cggggatccc      840

aaacagtgcg gtttttttaa catgatgtgc ctgaaagtgc attttaacca cgagatttgc      900

acacaagtct tccacaaaag catctctcgc cgttgcacta aatctgtgac ttcggtcgtc      960

tcaaccttgt tttacgacaa aaaaatgaga acgacgaatc cgaaagagac taagattgtg     1020

attgacacta ccggcagtac caaacctaag caggacgatc tcattctcac ttgtttcaga     1080

gggtgggtga agcagttgca aatagattac aaaggcaacg aaataatgac ggcagctgcc     1140

tctcaagggc tgacccgtaa aggtgtgtat gccgttcggt acaaggtgaa tgaaaatcct     1200

ctgtacgcac ccacctcaga acatgtgaac gtcctactga cccgcacgga ggaccgcatc     1260

gtgtggaaaa cactagccgg cgacccatgg ataaaaacac tgactgccaa gtaccctggg     1320

aatttcactg ccacgataga ggagtggcaa gcagagcatg atgccatcat gaggcacatc     1380

ttggagagac cggaccctac cgacgtcttc cagaataagg caaacgtgtg ttgggccaag     1440

gctttagtgc cggtgctgaa gaccgctggc atagacatga ccactgaaca atggaacact     1500

gtggattatt ttgaaacgga caaagctcac tcagcagaga tagtattgaa ccaactatgc     1560

gtgaggttct ttggactcga tctggactcc ggtctatttt ctgcacccac tgttccgtta     1620

tccattagga ataatcactg ggataactcc ccgtcgccta acatgtacgg gctgaataaa     1680

gaagtggtcc gtcagctctc tcgcaggtac ccacaactgc ctcgggcagt tgccactgga     1740

agagtctatg acatgaacac tggtacactg cgcaattatg atccgcgcat aaacctagta     1800

cctgtaaaca gaagactgcc tcatgcttta gtcctccacc ataatgaaca cccacagagt     1860

gacttttctt cattcgtcag caaattgaag ggcagaactg tcctggtggt cggggaaaag     1920

ttgtccgtcc caggcaaaat ggttgactgg ttgtcagacc ggcctgaggc taccttcaga     1980

gctcggctgg atttaggcat cccaggtgat gtgcccaaat atgacataat atttgttaat     2040

gtgaggaccc catataaata ccatcactat cagcagtgtg aagaccatgc cattaagctt     2100

agcatgttga ccaagaaagc ttgtctgcat ctgaatcccg gcggaacctg tgtcagcata     2160

ggttatggtt acgctgacag ggccagcgaa agcatcattg gtgctatagc gcggctgttc     2220

aagttttccc gggtatgcaa accgaaatcc tcacttgaag agacggaagt tctgtttgta     2280

ttcattgggt acgatcgcaa ggcccgtacg cacaatcctt acaagctttc atcaaccttg     2340

accaacattt atacaggttc cagactccac gaagccggat gt                        2382


<210>  6
<211>  1650
<212>  DNA
<213>  Venezuelan equine encephalitis virus

<400>  6
gcaccctcat atcatgtggt gcgaggggat attgccacgg ccaccgaagg agtgattata       60

aatgctgcta acagcaaagg acaacctggc ggaggggtgt gcggagcgct gtataagaaa      120

ttcccggaaa gcttcgattt acagccgatc gaagtaggaa aagcgcgact ggtcaaaggt      180

gcagctaaac atatcattca tgccgtagga ccaaacttca acaaagtttc ggaggttgaa      240

ggtgacaaac agttggcaga ggcttatgag tccatcgcta agattgtcaa cgataacaat      300

tacaagtcag tagcgattcc actgttgtcc accggcatct tttccgggaa caaagatcga      360

ctaacccaat cattgaacca tttgctgaca gctttagaca ccactgatgc agatgtagcc      420

atatactgca gggacaagaa atgggaaatg actctcaagg aagcagtggc taggagagaa      480

gcagtggagg agatatgcat atccgacgac tcttcagtga cagaacctga tgcagagctg      540

gtgagggtgc atccgaagag ttctttggct ggaaggaagg gctacagcac aagcgatggc      600

aaaactttct catatttgga agggaccaag tttcaccagg cggccaagga tatagcagaa      660

attaatgcca tgtggcccgt tgcaacggag gccaatgagc aggtatgcat gtatatcctc      720

ggagaaagca tgagcagtat taggtcgaaa tgccccgtcg aagagtcgga agcctccaca      780

ccacctagca cgctgccttg cttgtgcatc catgccatga ctccagaaag agtacagcgc      840

ctaaaagcct cacgtccaga acaaattact gtgtgctcat cctttccatt gccgaagtat      900

agaatcactg gtgtgcagaa gatccaatgc tcccagccta tattgttctc accgaaagtg      960

cctgcgtata ttcatccaag gaagtatctc gtggaaacac caccggtaga cgagactccg     1020

gagccatcgg cagagaacca atccacagag gggacacctg aacaaccacc acttataacc     1080

gaggatgaga ccaggactag aacgcctgag ccgatcatca tcgaagagga agaagaggat     1140

agcataagtt tgctgtcaga tggcccgacc caccaggtgc tgcaagtcga ggcagacatt     1200

cacgggccgc cctctgtatc tagctcatcc tggtccattc ctcatgcatc cgactttgat     1260

gtggacagtt tatccatact tgacaccctg gagggagcta gcgtgaccag cggggcaacg     1320

tcagccgaga ctaactctta cttcgcaaag agtatggagt ttctggcgcg accggtgcct     1380

gcgcctcgaa cagtattcag gaaccctcca catcccgctc cgcgcacaag aacaccgtca     1440

cttgcaccca gcagggcctg ctcgagaacc agcctagttt ccaccccgcc aggcgtgaat     1500

agggtgatca ctagagagga gctcgaggcg cttaccccgt cacgcactcc tagcaggtcg     1560

gtctcgagaa ccagcctggt ctccaacccg ccaggcgtaa atagggtgat tacaagagag     1620

gagtttgagg cgttcgtagc acaacaacaa                                      1650


<210>  7
<211>  1821
<212>  DNA
<213>  Venezuelan equine encephalitis virus

<400>  7
tacatctttt cctccgacac cggtcaaggg catttacaac aaaaatcagt aaggcaaacg       60

gtgctatccg aagtggtgtt ggagaggacc gaattggaga tttcgtatgc cccgcgcctc      120

gaccaagaaa aagaagaatt actacgcaag aaattacagt taaatcccac acctgctaac      180

agaagcagat accagtccag gaaggtggag aacatgaaag ccataacagc tagacgtatt      240

ctgcaaggcc tagggcatta tttgaaggca gaaggaaaag tggagtgcta ccgaaccctg      300

catcctgttc ctttgtattc atctagtgtg aaccgtgcct tttcaagccc caaggtcgca      360

gtggaagcct gtaacgccat gttgaaagag aactttccga ctgtggcttc ttactgtatt      420

attccagagt acgatgccta tttggacatg gttgacggag cttcatgctg cttagacact      480

gccagttttt gccctgcaaa gctgcgcagc tttccaaaga aacactccta tttggaaccc      540

acaatacgat cggcagtgcc ttcagcgatc cagaacacgc tccagaacgt cctggcagct      600

gccacaaaaa gaaattgcaa tgtcacgcaa atgagagaat tgcccgtatt ggattcggcg      660

gcctttaatg tggaatgctt caagaaatat gcgtgtaata atgaatattg ggaaacgttt      720

aaagaaaacc ccatcaggct tactgaagaa aacgtggtaa attacattac caaattaaaa      780

ggaccaaaag ctgctgctct ttttgcgaag acacataatt tgaatatgtt gcaggacata      840

ccaatggaca ggtttgtaat ggacttaaag agagacgtga aagtgactcc aggaacaaaa      900

catactgaag aacggcccaa ggtacaggtg atccaggctg ccgatccgct agcaacagcg      960

tatctgtgcg gaatccaccg agagctggtt aggagattaa atgcggtcct gcttccgaac     1020

attcatacac tgtttgatat gtcggctgaa gactttgacg ctattatagc cgagcacttc     1080

cagcctgggg attgtgttct ggaaactgac atcgcgtcgt ttgataaaag tgaggacgac     1140

gccatggctc tgaccgcgtt aatgattctg gaagacttag gtgtggacgc agagctgttg     1200

acgctgattg aggcggcttt cggcgaaatt tcatcaatac atttgcccac taaaactaaa     1260

tttaaattcg gagccatgat gaaatctgga atgttcctca cactgtttgt gaacacagtc     1320

attaacattg taatcgcaag cagagtgttg agagaacggc taaccggatc accatgtgca     1380

gcattcattg gagatgacaa tatcgtgaaa ggagtcaaat cggacaaatt aatggcagac     1440

aggtgcgcca cctggttgaa tatggaagtc aagattatag atgctgtggt gggcgagaaa     1500

gcgccttatt tctgtggagg gtttattttg tgtgactccg tgaccggcac agcgtgccgt     1560

gtggcagacc ccctaaaaag gctgtttaag cttggcaaac ctctggcagc agacgatgaa     1620

catgatgatg acaggagaag ggcattgcat gaagagtcaa cacgctggaa ccgagtgggt     1680

attctttcag agctgtgcaa ggcagtagaa tcaaggtatg aaaccgtagg aacttccatc     1740

atagttatgg ccatgactac tctagctagc agtgttaaat cattcagcta cctgagaggg     1800

gcccctataa ctctctacgg c                                               1821


<210>  8
<211>  535
<212>  PRT
<213>  Venezuelan equine encephalitis virus

<400>  8

Met Glu Lys Val His Val Asp Ile Glu Glu Asp Ser Pro Phe Leu Arg 
1               5                   10                  15      


Ala Leu Gln Arg Ser Phe Pro Gln Phe Glu Val Glu Ala Lys Gln Val 
            20                  25                  30          


Thr Asp Asn Asp His Ala Asn Ala Arg Ala Phe Ser His Leu Ala Ser 
        35                  40                  45              


Lys Leu Ile Glu Thr Glu Val Asp Pro Ser Asp Thr Ile Leu Asp Ile 
    50                  55                  60                  


Gly Ser Ala Pro Ala Arg Arg Met Tyr Ser Lys His Lys Tyr His Cys 
65                  70                  75                  80  


Ile Cys Pro Met Arg Cys Ala Glu Asp Pro Asp Arg Leu Tyr Lys Tyr 
                85                  90                  95      


Ala Thr Lys Leu Lys Lys Asn Cys Lys Glu Ile Thr Asp Lys Glu Leu 
            100                 105                 110         


Asp Lys Lys Met Lys Glu Leu Ala Ala Val Met Ser Asp Pro Asp Leu 
        115                 120                 125             


Glu Thr Glu Thr Met Cys Leu His Asp Asp Glu Ser Cys Arg Tyr Glu 
    130                 135                 140                 


Gly Gln Val Ala Val Tyr Gln Asp Val Tyr Ala Val Asp Gly Pro Thr 
145                 150                 155                 160 


Ser Leu Tyr His Gln Ala Asn Lys Gly Val Arg Val Ala Tyr Trp Ile 
                165                 170                 175     


Gly Phe Asp Thr Thr Pro Phe Met Phe Lys Asn Leu Ala Gly Ala Tyr 
            180                 185                 190         


Pro Ser Tyr Ser Thr Asn Trp Ala Asp Glu Thr Val Leu Thr Ala Arg 
        195                 200                 205             


Asn Ile Gly Leu Cys Ser Ser Asp Val Met Glu Arg Ser Arg Arg Gly 
    210                 215                 220                 


Met Ser Ile Leu Arg Lys Lys Tyr Leu Lys Pro Ser Asn Asn Val Leu 
225                 230                 235                 240 


Phe Ser Val Gly Ser Thr Ile Tyr His Glu Lys Arg Asp Leu Leu Arg 
                245                 250                 255     


Ser Trp His Leu Pro Ser Val Phe His Leu Arg Gly Lys Gln Asn Tyr 
            260                 265                 270         


Thr Cys Arg Cys Glu Thr Ile Val Ser Cys Asp Gly Tyr Val Val Lys 
        275                 280                 285             


Arg Ile Ala Ile Ser Pro Gly Leu Tyr Gly Lys Pro Ser Gly Tyr Ala 
    290                 295                 300                 


Ala Thr Met His Arg Glu Gly Phe Leu Cys Cys Lys Val Thr Asp Thr 
305                 310                 315                 320 


Leu Asn Gly Glu Arg Val Ser Phe Pro Val Cys Thr Tyr Val Pro Ala 
                325                 330                 335     


Thr Leu Cys Asp Gln Met Thr Gly Ile Leu Ala Thr Asp Val Ser Ala 
            340                 345                 350         


Asp Asp Ala Gln Lys Leu Leu Val Gly Leu Asn Gln Arg Ile Val Val 
        355                 360                 365             


Asn Gly Arg Thr Gln Arg Asn Thr Asn Thr Met Lys Asn Tyr Leu Leu 
    370                 375                 380                 


Pro Val Val Ala Gln Ala Phe Ala Arg Trp Ala Lys Glu Tyr Lys Glu 
385                 390                 395                 400 


Asp Gln Glu Asp Glu Arg Pro Leu Gly Leu Arg Asp Arg Gln Leu Val 
                405                 410                 415     


Met Gly Cys Cys Trp Ala Phe Arg Arg His Lys Ile Thr Ser Ile Tyr 
            420                 425                 430         


Lys Arg Pro Asp Thr Gln Thr Ile Ile Lys Val Asn Ser Asp Phe His 
        435                 440                 445             


Ser Phe Val Leu Pro Arg Ile Gly Ser Asn Thr Leu Glu Ile Gly Leu 
    450                 455                 460                 


Arg Thr Arg Ile Arg Lys Met Leu Glu Glu His Lys Glu Pro Ser Pro 
465                 470                 475                 480 


Leu Ile Thr Ala Glu Asp Val Gln Glu Ala Lys Cys Ala Ala Asp Glu 
                485                 490                 495     


Ala Lys Glu Val Arg Glu Ala Glu Glu Leu Arg Ala Ala Leu Pro Pro 
            500                 505                 510         


Leu Ala Ala Asp Val Glu Glu Pro Thr Leu Glu Ala Asp Val Asp Leu 
        515                 520                 525             


Met Leu Gln Glu Ala Gly Ala 
    530                 535 


<210>  9
<211>  794
<212>  PRT
<213>  Venezuelan equine encephalitis virus

<400>  9

Gly Ser Val Glu Thr Pro Arg Gly Leu Ile Lys Val Thr Ser Tyr Asp 
1               5                   10                  15      


Gly Glu Asp Lys Ile Gly Ser Tyr Ala Val Leu Ser Pro Gln Ala Val 
            20                  25                  30          


Leu Lys Ser Glu Lys Leu Ser Cys Ile His Pro Leu Ala Glu Gln Val 
        35                  40                  45              


Ile Val Ile Thr His Ser Gly Arg Lys Gly Arg Tyr Ala Val Glu Pro 
    50                  55                  60                  


Tyr His Gly Lys Val Val Val Pro Glu Gly His Ala Ile Pro Val Gln 
65                  70                  75                  80  


Asp Phe Gln Ala Leu Ser Glu Ser Ala Thr Ile Val Tyr Asn Glu Arg 
                85                  90                  95      


Glu Phe Val Asn Arg Tyr Leu His His Ile Ala Thr His Gly Gly Ala 
            100                 105                 110         


Leu Asn Thr Asp Glu Glu Tyr Tyr Lys Thr Val Lys Pro Ser Glu His 
        115                 120                 125             


Asp Gly Glu Tyr Leu Tyr Asp Ile Asp Arg Lys Gln Cys Val Lys Lys 
    130                 135                 140                 


Glu Leu Val Thr Gly Leu Gly Leu Thr Gly Glu Leu Val Asp Pro Pro 
145                 150                 155                 160 


Phe His Glu Phe Ala Tyr Glu Ser Leu Arg Thr Arg Pro Ala Ala Pro 
                165                 170                 175     


Tyr Gln Val Pro Thr Ile Gly Val Tyr Gly Val Pro Gly Ser Gly Lys 
            180                 185                 190         


Ser Gly Ile Ile Lys Ser Ala Val Thr Lys Lys Asp Leu Val Val Ser 
        195                 200                 205             


Ala Lys Lys Glu Asn Cys Ala Glu Ile Ile Arg Asp Val Lys Lys Met 
    210                 215                 220                 


Lys Gly Leu Asp Val Asn Ala Arg Thr Val Asp Ser Val Leu Leu Asn 
225                 230                 235                 240 


Gly Cys Lys His Pro Val Glu Thr Leu Tyr Ile Asp Glu Ala Phe Ala 
                245                 250                 255     


Cys His Ala Gly Thr Leu Arg Ala Leu Ile Ala Ile Ile Arg Pro Lys 
            260                 265                 270         


Lys Ala Val Leu Cys Gly Asp Pro Lys Gln Cys Gly Phe Phe Asn Met 
        275                 280                 285             


Met Cys Leu Lys Val His Phe Asn His Glu Ile Cys Thr Gln Val Phe 
    290                 295                 300                 


His Lys Ser Ile Ser Arg Arg Cys Thr Lys Ser Val Thr Ser Val Val 
305                 310                 315                 320 


Ser Thr Leu Phe Tyr Asp Lys Lys Met Arg Thr Thr Asn Pro Lys Glu 
                325                 330                 335     


Thr Lys Ile Val Ile Asp Thr Thr Gly Ser Thr Lys Pro Lys Gln Asp 
            340                 345                 350         


Asp Leu Ile Leu Thr Cys Phe Arg Gly Trp Val Lys Gln Leu Gln Ile 
        355                 360                 365             


Asp Tyr Lys Gly Asn Glu Ile Met Thr Ala Ala Ala Ser Gln Gly Leu 
    370                 375                 380                 


Thr Arg Lys Gly Val Tyr Ala Val Arg Tyr Lys Val Asn Glu Asn Pro 
385                 390                 395                 400 


Leu Tyr Ala Pro Thr Ser Glu His Val Asn Val Leu Leu Thr Arg Thr 
                405                 410                 415     


Glu Asp Arg Ile Val Trp Lys Thr Leu Ala Gly Asp Pro Trp Ile Lys 
            420                 425                 430         


Thr Leu Thr Ala Lys Tyr Pro Gly Asn Phe Thr Ala Thr Ile Glu Glu 
        435                 440                 445             


Trp Gln Ala Glu His Asp Ala Ile Met Arg His Ile Leu Glu Arg Pro 
    450                 455                 460                 


Asp Pro Thr Asp Val Phe Gln Asn Lys Ala Asn Val Cys Trp Ala Lys 
465                 470                 475                 480 


Ala Leu Val Pro Val Leu Lys Thr Ala Gly Ile Asp Met Thr Thr Glu 
                485                 490                 495     


Gln Trp Asn Thr Val Asp Tyr Phe Glu Thr Asp Lys Ala His Ser Ala 
            500                 505                 510         


Glu Ile Val Leu Asn Gln Leu Cys Val Arg Phe Phe Gly Leu Asp Leu 
        515                 520                 525             


Asp Ser Gly Leu Phe Ser Ala Pro Thr Val Pro Leu Ser Ile Arg Asn 
    530                 535                 540                 


Asn His Trp Asp Asn Ser Pro Ser Pro Asn Met Tyr Gly Leu Asn Lys 
545                 550                 555                 560 


Glu Val Val Arg Gln Leu Ser Arg Arg Tyr Pro Gln Leu Pro Arg Ala 
                565                 570                 575     


Val Ala Thr Gly Arg Val Tyr Asp Met Asn Thr Gly Thr Leu Arg Asn 
            580                 585                 590         


Tyr Asp Pro Arg Ile Asn Leu Val Pro Val Asn Arg Arg Leu Pro His 
        595                 600                 605             


Ala Leu Val Leu His His Asn Glu His Pro Gln Ser Asp Phe Ser Ser 
    610                 615                 620                 


Phe Val Ser Lys Leu Lys Gly Arg Thr Val Leu Val Val Gly Glu Lys 
625                 630                 635                 640 


Leu Ser Val Pro Gly Lys Met Val Asp Trp Leu Ser Asp Arg Pro Glu 
                645                 650                 655     


Ala Thr Phe Arg Ala Arg Leu Asp Leu Gly Ile Pro Gly Asp Val Pro 
            660                 665                 670         


Lys Tyr Asp Ile Ile Phe Val Asn Val Arg Thr Pro Tyr Lys Tyr His 
        675                 680                 685             


His Tyr Gln Gln Cys Glu Asp His Ala Ile Lys Leu Ser Met Leu Thr 
    690                 695                 700                 


Lys Lys Ala Cys Leu His Leu Asn Pro Gly Gly Thr Cys Val Ser Ile 
705                 710                 715                 720 


Gly Tyr Gly Tyr Ala Asp Arg Ala Ser Glu Ser Ile Ile Gly Ala Ile 
                725                 730                 735     


Ala Arg Leu Phe Lys Phe Ser Arg Val Cys Lys Pro Lys Ser Ser Leu 
            740                 745                 750         


Glu Glu Thr Glu Val Leu Phe Val Phe Ile Gly Tyr Asp Arg Lys Ala 
        755                 760                 765             


Arg Thr His Asn Pro Tyr Lys Leu Ser Ser Thr Leu Thr Asn Ile Tyr 
    770                 775                 780                 


Thr Gly Ser Arg Leu His Glu Ala Gly Cys 
785                 790                 


<210>  10
<211>  550
<212>  PRT
<213>  Venezuelan equine encephalitis virus

<400>  10

Ala Pro Ser Tyr His Val Val Arg Gly Asp Ile Ala Thr Ala Thr Glu 
1               5                   10                  15      


Gly Val Ile Ile Asn Ala Ala Asn Ser Lys Gly Gln Pro Gly Gly Gly 
            20                  25                  30          


Val Cys Gly Ala Leu Tyr Lys Lys Phe Pro Glu Ser Phe Asp Leu Gln 
        35                  40                  45              


Pro Ile Glu Val Gly Lys Ala Arg Leu Val Lys Gly Ala Ala Lys His 
    50                  55                  60                  


Ile Ile His Ala Val Gly Pro Asn Phe Asn Lys Val Ser Glu Val Glu 
65                  70                  75                  80  


Gly Asp Lys Gln Leu Ala Glu Ala Tyr Glu Ser Ile Ala Lys Ile Val 
                85                  90                  95      


Asn Asp Asn Asn Tyr Lys Ser Val Ala Ile Pro Leu Leu Ser Thr Gly 
            100                 105                 110         


Ile Phe Ser Gly Asn Lys Asp Arg Leu Thr Gln Ser Leu Asn His Leu 
        115                 120                 125             


Leu Thr Ala Leu Asp Thr Thr Asp Ala Asp Val Ala Ile Tyr Cys Arg 
    130                 135                 140                 


Asp Lys Lys Trp Glu Met Thr Leu Lys Glu Ala Val Ala Arg Arg Glu 
145                 150                 155                 160 


Ala Val Glu Glu Ile Cys Ile Ser Asp Asp Ser Ser Val Thr Glu Pro 
                165                 170                 175     


Asp Ala Glu Leu Val Arg Val His Pro Lys Ser Ser Leu Ala Gly Arg 
            180                 185                 190         


Lys Gly Tyr Ser Thr Ser Asp Gly Lys Thr Phe Ser Tyr Leu Glu Gly 
        195                 200                 205             


Thr Lys Phe His Gln Ala Ala Lys Asp Ile Ala Glu Ile Asn Ala Met 
    210                 215                 220                 


Trp Pro Val Ala Thr Glu Ala Asn Glu Gln Val Cys Met Tyr Ile Leu 
225                 230                 235                 240 


Gly Glu Ser Met Ser Ser Ile Arg Ser Lys Cys Pro Val Glu Glu Ser 
                245                 250                 255     


Glu Ala Ser Thr Pro Pro Ser Thr Leu Pro Cys Leu Cys Ile His Ala 
            260                 265                 270         


Met Thr Pro Glu Arg Val Gln Arg Leu Lys Ala Ser Arg Pro Glu Gln 
        275                 280                 285             


Ile Thr Val Cys Ser Ser Phe Pro Leu Pro Lys Tyr Arg Ile Thr Gly 
    290                 295                 300                 


Val Gln Lys Ile Gln Cys Ser Gln Pro Ile Leu Phe Ser Pro Lys Val 
305                 310                 315                 320 


Pro Ala Tyr Ile His Pro Arg Lys Tyr Leu Val Glu Thr Pro Pro Val 
                325                 330                 335     


Asp Glu Thr Pro Glu Pro Ser Ala Glu Asn Gln Ser Thr Glu Gly Thr 
            340                 345                 350         


Pro Glu Gln Pro Pro Leu Ile Thr Glu Asp Glu Thr Arg Thr Arg Thr 
        355                 360                 365             


Pro Glu Pro Ile Ile Ile Glu Glu Glu Glu Glu Asp Ser Ile Ser Leu 
    370                 375                 380                 


Leu Ser Asp Gly Pro Thr His Gln Val Leu Gln Val Glu Ala Asp Ile 
385                 390                 395                 400 


His Gly Pro Pro Ser Val Ser Ser Ser Ser Trp Ser Ile Pro His Ala 
                405                 410                 415     


Ser Asp Phe Asp Val Asp Ser Leu Ser Ile Leu Asp Thr Leu Glu Gly 
            420                 425                 430         


Ala Ser Val Thr Ser Gly Ala Thr Ser Ala Glu Thr Asn Ser Tyr Phe 
        435                 440                 445             


Ala Lys Ser Met Glu Phe Leu Ala Arg Pro Val Pro Ala Pro Arg Thr 
    450                 455                 460                 


Val Phe Arg Asn Pro Pro His Pro Ala Pro Arg Thr Arg Thr Pro Ser 
465                 470                 475                 480 


Leu Ala Pro Ser Arg Ala Cys Ser Arg Thr Ser Leu Val Ser Thr Pro 
                485                 490                 495     


Pro Gly Val Asn Arg Val Ile Thr Arg Glu Glu Leu Glu Ala Leu Thr 
            500                 505                 510         


Pro Ser Arg Thr Pro Ser Arg Ser Val Ser Arg Thr Ser Leu Val Ser 
        515                 520                 525             


Asn Pro Pro Gly Val Asn Arg Val Ile Thr Arg Glu Glu Phe Glu Ala 
    530                 535                 540                 


Phe Val Ala Gln Gln Gln 
545                 550 


<210>  11
<211>  607
<212>  PRT
<213>  Venezuelan equine encephalitis virus

<400>  11

Tyr Ile Phe Ser Ser Asp Thr Gly Gln Gly His Leu Gln Gln Lys Ser 
1               5                   10                  15      


Val Arg Gln Thr Val Leu Ser Glu Val Val Leu Glu Arg Thr Glu Leu 
            20                  25                  30          


Glu Ile Ser Tyr Ala Pro Arg Leu Asp Gln Glu Lys Glu Glu Leu Leu 
        35                  40                  45              


Arg Lys Lys Leu Gln Leu Asn Pro Thr Pro Ala Asn Arg Ser Arg Tyr 
    50                  55                  60                  


Gln Ser Arg Arg Val Glu Asn Met Lys Ala Ile Thr Ala Arg Arg Ile 
65                  70                  75                  80  


Leu Gln Gly Leu Gly His Tyr Leu Lys Ala Glu Gly Lys Val Glu Cys 
                85                  90                  95      


Tyr Arg Thr Leu His Pro Val Pro Leu Tyr Ser Ser Ser Val Asn Arg 
            100                 105                 110         


Ala Phe Ser Ser Pro Lys Val Ala Val Glu Ala Cys Asn Ala Met Leu 
        115                 120                 125             


Lys Glu Asn Phe Pro Thr Val Ala Ser Tyr Cys Ile Ile Pro Glu Tyr 
    130                 135                 140                 


Asp Ala Tyr Leu Asp Met Val Asp Gly Ala Ser Cys Cys Leu Asp Thr 
145                 150                 155                 160 


Ala Ser Phe Cys Pro Ala Lys Leu Arg Ser Phe Pro Lys Lys His Ser 
                165                 170                 175     


Tyr Leu Glu Pro Thr Ile Arg Ser Ala Val Pro Ser Ala Ile Gln Asn 
            180                 185                 190         


Thr Leu Gln Asn Val Leu Ala Ala Ala Thr Lys Arg Asn Cys Asn Val 
        195                 200                 205             


Thr Gln Met Arg Glu Leu Pro Val Leu Asp Ser Ala Ala Phe Asn Val 
    210                 215                 220                 


Glu Cys Phe Lys Lys Tyr Ala Cys Asn Asn Glu Tyr Trp Glu Thr Phe 
225                 230                 235                 240 


Lys Glu Asn Pro Ile Arg Leu Thr Glu Glu Asn Val Val Asn Tyr Ile 
                245                 250                 255     


Thr Lys Leu Lys Gly Pro Lys Ala Ala Ala Leu Phe Ala Lys Thr His 
            260                 265                 270         


Asn Leu Asn Met Leu Gln Asp Ile Pro Met Asp Arg Phe Val Met Asp 
        275                 280                 285             


Leu Lys Arg Asp Val Lys Val Thr Pro Gly Thr Lys His Thr Glu Glu 
    290                 295                 300                 


Arg Pro Lys Val Gln Val Ile Gln Ala Ala Asp Pro Leu Ala Thr Ala 
305                 310                 315                 320 


Asp Leu Cys Gly Ile His Arg Glu Leu Val Arg Arg Leu Asn Ala Val 
                325                 330                 335     


Leu Leu Pro Asn Ile His Thr Leu Phe Asp Met Ser Ala Glu Asp Phe 
            340                 345                 350         


Asp Ala Ile Ile Ala Glu His Phe Gln Pro Gly Asp Cys Val Leu Glu 
        355                 360                 365             


Thr Asp Ile Ala Ser Phe Asp Lys Ser Glu Asp Asp Ala Met Ala Leu 
    370                 375                 380                 


Thr Ala Leu Met Ile Leu Glu Asp Leu Gly Val Asp Ala Glu Leu Leu 
385                 390                 395                 400 


Thr Leu Ile Glu Ala Ala Phe Gly Glu Ile Ser Ser Ile His Leu Pro 
                405                 410                 415     


Thr Lys Thr Lys Phe Lys Phe Gly Ala Met Met Lys Ser Gly Met Phe 
            420                 425                 430         


Leu Thr Leu Phe Val Asn Thr Val Ile Asn Ile Val Ile Ala Ser Arg 
        435                 440                 445             


Val Leu Arg Glu Arg Leu Thr Gly Ser Pro Cys Ala Ala Phe Ile Gly 
    450                 455                 460                 


Asp Asp Asn Ile Val Lys Gly Val Lys Ser Asp Lys Leu Met Ala Asp 
465                 470                 475                 480 


Arg Cys Ala Thr Trp Leu Asn Met Glu Val Lys Ile Ile Asp Ala Val 
                485                 490                 495     


Val Gly Glu Lys Ala Pro Tyr Phe Cys Gly Gly Phe Ile Leu Cys Asp 
            500                 505                 510         


Ser Val Thr Gly Thr Ala Cys Arg Val Ala Asp Pro Leu Lys Arg Leu 
        515                 520                 525             


Phe Lys Leu Gly Lys Pro Leu Ala Val Asp Asp Glu His Asp Asp Asp 
    530                 535                 540                 


Arg Arg Arg Ala Leu His Glu Glu Ser Thr Arg Trp Asn Arg Val Gly 
545                 550                 555                 560 


Ile Leu Pro Glu Leu Cys Lys Ala Val Glu Ser Arg Tyr Glu Thr Val 
                565                 570                 575     


Gly Thr Ser Ile Ile Val Met Ala Met Thr Thr Leu Ala Ser Ser Val 
            580                 585                 590         


Lys Ser Phe Ser Tyr Leu Arg Gly Ala Pro Ile Thr Leu Tyr Gly 
        595                 600                 605         


<210>  12
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
atggactacg acatagtcta gtccgccaag                                        30


<210>  13
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
atggactacg acata                                                        15


<210>  14
<211>  264
<212>  PRT
<213>  Pyrococcus furiosus

<400>  14

Met Arg Phe Leu Ile Arg Leu Val Pro Glu Asp Lys Asp Arg Ala Phe 
1               5                   10                  15      


Lys Val Pro Tyr Asn His Gln Tyr Tyr Leu Gln Gly Leu Ile Tyr Asn 
            20                  25                  30          


Ala Ile Lys Ser Ser Asn Pro Lys Leu Ala Thr Tyr Leu His Glu Val 
        35                  40                  45              


Lys Gly Pro Lys Leu Phe Thr Tyr Ser Leu Phe Met Ala Glu Lys Arg 
    50                  55                  60                  


Glu His Pro Lys Gly Leu Pro Tyr Phe Leu Gly Tyr Lys Lys Gly Phe 
65                  70                  75                  80  


Phe Tyr Phe Ser Thr Cys Val Pro Glu Ile Ala Glu Ala Leu Val Asn 
                85                  90                  95      


Gly Leu Leu Met Asn Pro Glu Val Arg Leu Trp Asp Glu Arg Phe Tyr 
            100                 105                 110         


Leu His Glu Ile Lys Val Leu Arg Glu Pro Lys Lys Phe Asn Gly Ser 
        115                 120                 125             


Thr Phe Val Thr Leu Ser Pro Ile Ala Val Thr Val Val Arg Lys Gly 
    130                 135                 140                 


Lys Ser Tyr Asp Val Pro Pro Met Glu Lys Glu Phe Tyr Ser Ile Ile 
145                 150                 155                 160 


Lys Asp Asp Leu Gln Asp Lys Tyr Val Met Ala Tyr Gly Asp Lys Pro 
                165                 170                 175     


Pro Ser Glu Phe Glu Met Glu Val Leu Ile Ala Lys Pro Lys Arg Phe 
            180                 185                 190         


Arg Ile Lys Pro Gly Ile Tyr Gln Thr Ala Trp His Leu Val Phe Arg 
        195                 200                 205             


Ala Tyr Gly Asn Asp Asp Leu Leu Lys Val Gly Tyr Glu Val Gly Phe 
    210                 215                 220                 


Gly Glu Lys Asn Ser Leu Gly Phe Gly Met Val Lys Val Glu Gly Asn 
225                 230                 235                 240 


Lys Thr Thr Lys Glu Ala Glu Glu Gln Glu Lys Ile Thr Phe Asn Ser 
                245                 250                 255     


Arg Glu Glu Leu Lys Thr Gly Val 
            260                 


<210>  15
<211>  187
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  15

Met Asp His Tyr Leu Asp Ile Arg Leu Arg Pro Asp Pro Glu Phe Pro 
1               5                   10                  15      


Pro Ala Gln Leu Met Ser Val Leu Phe Gly Lys Leu His Gln Ala Leu 
            20                  25                  30          


Val Ala Gln Gly Gly Asp Arg Ile Gly Val Ser Phe Pro Asp Leu Asp 
        35                  40                  45              


Glu Ser Arg Ser Arg Leu Gly Glu Arg Leu Arg Ile His Ala Ser Ala 
    50                  55                  60                  


Asp Asp Leu Arg Ala Leu Leu Ala Arg Pro Trp Leu Glu Gly Leu Arg 
65                  70                  75                  80  


Asp His Leu Gln Phe Gly Glu Pro Ala Val Val Pro His Pro Thr Pro 
                85                  90                  95      


Tyr Arg Gln Val Ser Arg Val Gln Ala Lys Ser Asn Pro Glu Arg Leu 
            100                 105                 110         


Arg Arg Arg Leu Met Arg Arg His Asp Leu Ser Glu Glu Glu Ala Arg 
        115                 120                 125             


Lys Arg Ile Pro Asp Thr Val Ala Arg Ala Leu Asp Leu Pro Phe Val 
    130                 135                 140                 


Thr Leu Arg Ser Gln Ser Thr Gly Gln His Phe Arg Leu Phe Ile Arg 
145                 150                 155                 160 


His Gly Pro Leu Gln Val Thr Ala Glu Glu Gly Gly Phe Thr Cys Tyr 
                165                 170                 175     


Gly Leu Ser Lys Gly Gly Phe Val Pro Trp Phe 
            180                 185         


<210>  16
<211>  199
<212>  PRT
<213>  Escherichia coli

<400>  16

Met Tyr Leu Ser Lys Ile Ile Ile Ala Arg Ala Trp Ser Arg Asp Leu 
1               5                   10                  15      


Tyr Gln Leu His Gln Glu Leu Trp His Leu Phe Pro Asn Arg Pro Asp 
            20                  25                  30          


Ala Ala Arg Asp Phe Leu Phe His Val Glu Lys Arg Asn Thr Pro Glu 
        35                  40                  45              


Gly Cys His Val Leu Leu Gln Ser Ala Gln Met Pro Val Ser Thr Ala 
    50                  55                  60                  


Val Ala Thr Val Ile Lys Thr Lys Gln Val Glu Phe Gln Leu Gln Val 
65                  70                  75                  80  


Gly Val Pro Leu Tyr Phe Arg Leu Arg Ala Asn Pro Ile Lys Thr Ile 
                85                  90                  95      


Leu Asp Asn Gln Lys Arg Leu Asp Ser Lys Gly Asn Ile Lys Arg Cys 
            100                 105                 110         


Arg Val Pro Leu Ile Lys Glu Ala Glu Gln Ile Ala Trp Leu Gln Arg 
        115                 120                 125             


Lys Leu Gly Asn Ala Ala Arg Val Glu Asp Val His Pro Ile Ser Glu 
    130                 135                 140                 


Arg Pro Gln Tyr Phe Ser Gly Glu Gly Lys Asn Gly Lys Ile Gln Thr 
145                 150                 155                 160 


Val Cys Phe Glu Gly Val Leu Thr Ile Asn Asp Ala Pro Ala Leu Ile 
                165                 170                 175     


Asp Leu Leu Gln Gln Gly Ile Gly Pro Ala Lys Ser Met Gly Cys Gly 
            180                 185                 190         


Leu Leu Ser Leu Ala Pro Leu 
        195                 


<210>  17
<211>  211
<212>  PRT
<213>  Thermus thermophilus

<400>  17

Met Trp Leu Thr Lys Leu Val Leu Asn Pro Ala Ser Arg Ala Ala Arg 
1               5                   10                  15      


Arg Asp Leu Ala Asn Pro Tyr Glu Met His Arg Thr Leu Ser Lys Ala 
            20                  25                  30          


Val Ser Arg Ala Leu Glu Glu Gly Arg Glu Arg Leu Leu Trp Arg Leu 
        35                  40                  45              


Glu Pro Ala Arg Gly Leu Glu Pro Pro Val Val Leu Val Gln Thr Leu 
    50                  55                  60                  


Thr Glu Pro Asp Trp Ser Val Leu Asp Glu Gly Tyr Ala Gln Val Phe 
65                  70                  75                  80  


Pro Pro Lys Pro Phe His Pro Ala Leu Lys Pro Gly Gln Arg Leu Arg 
                85                  90                  95      


Phe Arg Leu Arg Ala Asn Pro Ala Lys Arg Leu Ala Ala Thr Gly Lys 
            100                 105                 110         


Arg Val Ala Leu Lys Thr Pro Ala Glu Lys Val Ala Trp Leu Glu Arg 
        115                 120                 125             


Arg Leu Glu Glu Gly Gly Phe Arg Leu Leu Glu Gly Glu Arg Gly Pro 
    130                 135                 140                 


Trp Val Gln Ile Leu Gln Asp Thr Phe Leu Glu Val Arg Arg Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Glu Ala Gly Lys Leu Leu Gln Val Gln Ala Val Leu Phe 
                165                 170                 175     


Glu Gly Arg Leu Glu Val Val Asp Pro Glu Arg Ala Leu Ala Thr Leu 
            180                 185                 190         


Arg Arg Gly Val Gly Pro Gly Lys Ala Leu Gly Leu Gly Leu Leu Ser 
        195                 200                 205             


Val Ala Pro 
    210     


<210>  18
<211>  795
<212>  DNA
<213>  Pyrococcus furiosus

<400>  18
atgcgcttcc tcattcgtct cgtgcctgag gataaggatc gggcctttaa agtgccatat       60

aaccatcagt attacctgca gggcctcatc tataatgcca tcaaatcctc caatccgaag      120

ctggccacct acctgcatga ggtgaagggt cccaaactgt tcacctacag cctgtttatg      180

gccgaaaaac gcgaacaccc taaggggctg ccttactttt tggggtacaa gaagggcttc      240

ttctactttt ctacctgcgt gccggagatc gctgaagcac tggtcaacgg actcctgatg      300

aatccagagg tgcgcctgtg ggacgaacgc ttctacctgc acgaaattaa ggttttgaga      360

gagcctaaga agttcaacgg ctctaccttc gtcaccctgt ctccgattgc tgtgactgtc      420

gtgaggaagg gtaagagtta tgatgtcccc cctatggaga aggagtttta cagtatcatc      480

aaagacgacc tgcaagataa gtatgtgatg gcctacggcg acaagccccc atccgaattc      540

gagatggagg tgctgattgc taagccgaaa cggtttcgta ttaagcctgg catctatcag      600

acagcctggc acctggtttt tagggcctac ggaaacgacg acctgctgaa ggttggttac      660

gaggttgggt tcggagaaaa gaactccctg ggattcggca tggtgaaggt ggaggggaac      720

aagaccacaa aagaagctga agagcaggaa aagatcacct tcaactctcg cgaggagctg      780

aagaccggcg tgtga                                                       795


<210>  19
<211>  564
<212>  DNA
<213>  Pseudomonas aeruginosa

<400>  19
atggaccact atctggacat cagactgagg cccgatcctg agttccctcc cgcccagctg       60

atgagcgtgc tgtttggcaa gctgcatcag gctctggtcg cccaaggcgg agacagaatc      120

ggcgtgtcct tccccgacct ggacgagtcc cggagtcgcc tgggcgagcg gctgagaatc      180

cacgccagcg cagacgatct gcgcgccctg ctggcccggc cttggctgga gggcctgcgg      240

gatcatctgc agtttggcga gcccgccgtg gtgccacacc caacacccta ccgccaggtg      300

agccgcgtgc aggccaagtc aaatcccgag agactgcggc ggaggctgat gaggcgacat      360

gatctgagcg aggaggaggc cagaaagaga atccccgaca cagtggccag agccctggat      420

ctgccatttg tgaccctgcg gagccagagc actggccagc atttcagact gttcatcaga      480

cacgggcccc tgcaggtgac agccgaggag ggcggattta catgctatgg cctgtctaaa      540

ggcggcttcg tgccctggtt ctga                                             564


<210>  20
<211>  597
<212>  DNA
<213>  Escherichia coli

<400>  20
atgtacctca gtaagatcat catcgcccgc gcttggtccc gtgacctgta ccaactgcac       60

caagagctct ggcacctctt ccccaacagg ccagatgccg ctagagactt cctgttccac      120

gtggagaagc gtaacacccc cgaagggtgc cacgtgctgt tgcagagtgc ccagatgcca      180

gtgagtaccg ctgttgccac tgtcatcaag actaaacaag ttgaattcca actgcaagtg      240

ggcgtccctc tgtatttccg cctcagggcc aaccccatca aaaccatcct ggacaaccag      300

aagcggctgg atagcaaagg taatatcaag agatgccgcg tgcctctgat caaggaggcc      360

gagcagatcg cttggctgca acgcaagctg ggtaacgccg cgagagtgga agatgtgcac      420

ccaatctccg agcgcccgca gtatttctcc ggggagggga agaacggcaa aattcagact      480

gtctgcttcg agggggtgct cactattaac gacgcccctg ctctgatcga cctcctgcag      540

cagggcattg ggcccgcgaa gagcatggga tgcggattgt tgagcctggc acccctg         597


<210>  21
<211>  636
<212>  DNA
<213>  Thermus thermophilus

<400>  21
atgtggttga ccaaattggt tctgaatcct gcgagccgcg cagcacggcg cgatttggct       60

aacccttacg agatgcatcg gactctttca aaagcggtta gcagggcttt ggaagaaggg      120

cgcgagcgcc ttttgtggag gctggagcca gctcggggac tggagccccc tgtcgtcctg      180

gtgcagaccc tcactgagcc tgattggtcc gtacttgatg aaggttacgc acaggtcttt      240

cctcctaagc ctttccaccc agcattgaag ccgggccagc ggctccgctt taggctccgg      300

gcgaatcccg ccaaacggtt ggctgccacc ggaaagcgag ttgcgttgaa aacgcccgcc      360

gaaaaagtgg cgtggcttga gaggcggctg gaggagggtg gttttcgact ccttgaaggg      420

gaaaggggac catgggtaca gatacttcaa gatacgttcc tggaggtgcg gagaaaaaaa      480

gacggagaag aggcaggcaa gctgcttcaa gtccaagccg tcttgttcga ggggagactc      540

gaagttgttg atcctgagag agcacttgcg acactgagac gaggggtggg acctggtaaa      600

gcgctgggtc ttggacttct tagtgttgca ccatga                                636


<210>  22
<211>  29
<212>  DNA
<213>  Pyrococcus furiosus

<400>  22
gttacaataa gactaaatag aattgaaag                                         29


<210>  23
<211>  28
<212>  DNA
<213>  Pseudomonas aeruginosa

<400>  23
gttcactgcc gtataggcag ctaagaaa                                          28


<210>  24
<211>  29
<212>  DNA
<213>  Escherichia coli

<400>  24
gagttccccg cgccagcggg gataaaccg                                         29


<210>  25
<211>  29
<212>  DNA
<213>  Thermus thermophilus

<400>  25
gtagtcccca cgcgtgtggg gatggaccg                                         29


