                         SEQUENCE LISTING

<110>  President and Fellows of Harvard College
 
<120>  HIGHLY MULTIPLEXED BASE EDITING

<130>  H0824.70316WO00

<140>  Not Yet Assigned
<141>  Concurrenty Herewith

<150>  US 62/813,672
<151>  2019-03-04

<160>  148   

<170>  PatentIn version 3.5

<210>  1
<211>  167
<212>  PRT
<213>  E. Coli

<400>  1

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp 
                165         


<210>  2
<211>  178
<212>  PRT
<213>  E. Coli

<400>  2

Met Arg Arg Ala Phe Ile Thr Gly Val Phe Phe Leu Ser Glu Val Glu 
1               5                   10                  15      


Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg 
            20                  25                  30          


Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn 
        35                  40                  45              


Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp 
    50                  55                  60                  


Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val 
65                  70                  75                  80  


Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu 
                85                  90                  95      


Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg 
            100                 105                 110         


Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu 
        115                 120                 125             


Met Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr 
    130                 135                 140                 


Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe 
145                 150                 155                 160 


Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser 
                165                 170                 175     


Thr Asp 
        


<210>  3
<211>  1853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Lys Trp Gly Thr 
    50                  55                  60                  


Ser His Lys Ile Trp Arg His Ser Ser Lys Asn Thr Thr Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Ser Glu Arg His Phe Cys Pro 
                85                  90                  95      


Ser Thr Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Lys Ala Ile Thr Glu Phe Leu Ser Gln His Pro Asn Val 
        115                 120                 125             


Thr Leu Val Ile Tyr Val Ala Arg Leu Tyr His His Met Asp Gln Gln 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Ala Pro Glu Tyr Asp Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Pro Pro Gly Lys Glu Ala His Trp Pro Arg Tyr Pro Pro Leu Trp 
            180                 185                 190         


Met Lys Leu Tyr Ala Leu Glu Leu His Ala Gly Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val 
    1850             


<210>  4
<211>  1803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val 
                325                 330                 335     


Leu His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


<210>  5
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Thr Asn Leu Ser Asp Ile Ile Glu Lys Glu Thr Gly Lys Gln Leu 
1               5                   10                  15      


Val Ile Gln Glu Ser Ile Leu Met Leu Pro Glu Glu Val Glu Glu Val 
            20                  25                  30          


Ile Gly Asn Lys Pro Glu Ser Asp Ile Leu Val His Thr Ala Tyr Asp 
        35                  40                  45              


Glu Ser Thr Asp Glu Asn Val Met Leu Leu Thr Ser Asp Ala Pro Glu 
    50                  55                  60                  


Tyr Lys Pro Trp Ala Leu Val Ile Gln Asp Ser Asn Gly Glu Asn Lys 
65                  70                  75                  80  


Ile Lys Met Leu 
                


<210>  6
<211>  2136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
            20                  25                  30          


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
        35                  40                  45              


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Lys Trp Gly Thr 
    50                  55                  60                  


Ser His Lys Ile Trp Arg His Ser Ser Lys Asn Thr Thr Lys His Val 
65                  70                  75                  80  


Glu Val Asn Phe Ile Glu Lys Phe Thr Ser Glu Arg His Phe Cys Pro 
                85                  90                  95      


Ser Thr Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly 
            100                 105                 110         


Glu Cys Ser Lys Ala Ile Thr Glu Phe Leu Ser Gln His Pro Asn Val 
        115                 120                 125             


Thr Leu Val Ile Tyr Val Ala Arg Leu Tyr His His Met Asp Gln Gln 
    130                 135                 140                 


Asn Arg Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln 
145                 150                 155                 160 


Ile Met Thr Ala Pro Glu Tyr Asp Tyr Cys Trp Arg Asn Phe Val Asn 
                165                 170                 175     


Tyr Pro Pro Gly Lys Glu Ala His Trp Pro Arg Tyr Pro Pro Leu Trp 
            180                 185                 190         


Met Lys Leu Tyr Ala Leu Glu Leu His Ala Gly Ile Leu Gly Leu Pro 
        195                 200                 205             


Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe 
    210                 215                 220                 


Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile 
225                 230                 235                 240 


Leu Trp Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp 
        275                 280                 285             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
    290                 295                 300                 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
305                 310                 315                 320 


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                325                 330                 335     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            340                 345                 350         


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
        355                 360                 365             


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
    370                 375                 380                 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
385                 390                 395                 400 


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
                405                 410                 415     


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
            420                 425                 430         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
        435                 440                 445             


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
    450                 455                 460                 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
465                 470                 475                 480 


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
                485                 490                 495     


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
            500                 505                 510         


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
        515                 520                 525             


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
    530                 535                 540                 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
545                 550                 555                 560 


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
                565                 570                 575     


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
            580                 585                 590         


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
        595                 600                 605             


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
625                 630                 635                 640 


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
                645                 650                 655     


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
            660                 665                 670         


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        675                 680                 685             


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
    690                 695                 700                 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
705                 710                 715                 720 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
                725                 730                 735     


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
            740                 745                 750         


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
        755                 760                 765             


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
    770                 775                 780                 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
                805                 810                 815     


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
            820                 825                 830         


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
        835                 840                 845             


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
    850                 855                 860                 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
865                 870                 875                 880 


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
                885                 890                 895     


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
            900                 905                 910         


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
        915                 920                 925             


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    930                 935                 940                 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
945                 950                 955                 960 


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
                965                 970                 975     


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
            980                 985                 990         


Gly Gln Gly Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
        995                 1000                 1005             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1010                 1015                 1020             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1025                 1030                 1035             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1040                 1045                 1050             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1055                 1060                 1065             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1070                 1075                 1080             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1085                 1090                 1095             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1100                 1105                 1110             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1115                 1120                 1125             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1130                 1135                 1140             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1145                 1150                 1155             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1160                 1165                 1170             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1190                 1195                 1200             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1205                 1210                 1215             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1220                 1225                 1230             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1235                 1240                 1245             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1250                 1255                 1260             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1265                 1270                 1275             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1280                 1285                 1290             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1295                 1300                 1305             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1310                 1315                 1320             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1325                 1330                 1335             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1340                 1345                 1350             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1355                 1360                 1365             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1370                 1375                 1380             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1385                 1390                 1395             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1400                 1405                 1410             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1415                 1420                 1425             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1430                 1435                 1440             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1445                 1450                 1455             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1460                 1465                 1470             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1475                 1480                 1485             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1490                 1495                 1500             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1505                 1510                 1515             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1520                 1525                 1530             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1535                 1540                 1545             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1550                 1555                 1560             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1565                 1570                 1575             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1580                 1585                 1590             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1595                 1600                 1605             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1610                 1615                 1620             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1625                 1630                 1635             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Gly Gly Ser 
    1640                 1645                 1650             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1655                 1660                 1665             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1670                 1675                 1680             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1685                 1690                 1695             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1700                 1705                 1710             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1715                 1720                 1725             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1730                 1735                 1740             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1745                 1750                 1755             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1760                 1765                 1770             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1775                 1780                 1785             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1790                 1795                 1800             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1805                 1810                 1815             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1820                 1825                 1830             


Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys 
    1835                 1840                 1845             


Lys Lys  Arg Lys Val Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1850                 1855                 1860             


Val Gly  Ser Gly Ala Thr Asn  Phe Ser Leu Leu Lys  Gln Ala Gly 
    1865                 1870                 1875             


Asp Val  Glu Glu Asn Pro Gly  Pro Met Val Ser Lys  Gly Glu Glu 
    1880                 1885                 1890             


Leu Phe  Thr Gly Val Val Pro  Ile Leu Val Glu Leu  Asp Gly Asp 
    1895                 1900                 1905             


Val Asn  Gly His Lys Phe Ser  Val Ser Gly Glu Gly  Glu Gly Asp 
    1910                 1915                 1920             


Ala Thr  Tyr Gly Lys Leu Thr  Leu Lys Phe Ile Cys  Thr Thr Gly 
    1925                 1930                 1935             


Lys Leu  Pro Val Pro Trp Pro  Thr Leu Val Thr Thr  Leu Thr Tyr 
    1940                 1945                 1950             


Gly Val  Gln Cys Phe Ser Arg  Tyr Pro Asp His Met  Lys Gln His 
    1955                 1960                 1965             


Asp Phe  Phe Lys Ser Ala Met  Pro Glu Gly Tyr Val  Gln Glu Arg 
    1970                 1975                 1980             


Thr Ile  Phe Phe Lys Asp Asp  Gly Asn Tyr Lys Thr  Arg Ala Glu 
    1985                 1990                 1995             


Val Lys  Phe Glu Gly Asp Thr  Leu Val Asn Arg Ile  Glu Leu Lys 
    2000                 2005                 2010             


Gly Ile  Asp Phe Lys Glu Asp  Gly Asn Ile Leu Gly  His Lys Leu 
    2015                 2020                 2025             


Glu Tyr  Asn Tyr Asn Ser His  Asn Val Tyr Ile Met  Ala Asp Lys 
    2030                 2035                 2040             


Gln Lys  Asn Gly Ile Lys Val  Asn Phe Lys Ile Arg  His Asn Ile 
    2045                 2050                 2055             


Glu Asp  Gly Ser Val Gln Leu  Ala Asp His Tyr Gln  Gln Asn Thr 
    2060                 2065                 2070             


Pro Ile  Gly Asp Gly Pro Val  Leu Leu Pro Asp Asn  His Tyr Leu 
    2075                 2080                 2085             


Ser Thr  Gln Ser Ala Leu Ser  Lys Asp Pro Asn Glu  Lys Arg Asp 
    2090                 2095                 2100             


His Met  Val Leu Leu Glu Phe  Val Thr Ala Ala Gly  Ile Thr Leu 
    2105                 2110                 2115             


Gly Met  Asp Glu Leu Tyr Lys  Ser Gly Gly Ser Pro  Lys Lys Lys 
    2120                 2125                 2130             


Arg Lys  Val 
    2135     


<210>  7
<211>  2086
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val 
                325                 330                 335     


Leu His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Ser Gly Gly  Ser Lys Arg 
    1775                 1780                 1785             


Thr Ala  Asp Gly Ser Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795                 1800             


Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val Gly  Ser Gly Ala 
    1805                 1810                 1815             


Thr Asn  Phe Ser Leu Leu Lys  Gln Ala Gly Asp Val  Glu Glu Asn 
    1820                 1825                 1830             


Pro Gly  Pro Met Val Ser Lys  Gly Glu Glu Leu Phe  Thr Gly Val 
    1835                 1840                 1845             


Val Pro  Ile Leu Val Glu Leu  Asp Gly Asp Val Asn  Gly His Lys 
    1850                 1855                 1860             


Phe Ser  Val Ser Gly Glu Gly  Glu Gly Asp Ala Thr  Tyr Gly Lys 
    1865                 1870                 1875             


Leu Thr  Leu Lys Phe Ile Cys  Thr Thr Gly Lys Leu  Pro Val Pro 
    1880                 1885                 1890             


Trp Pro  Thr Leu Val Thr Thr  Leu Thr Tyr Gly Val  Gln Cys Phe 
    1895                 1900                 1905             


Ser Arg  Tyr Pro Asp His Met  Lys Gln His Asp Phe  Phe Lys Ser 
    1910                 1915                 1920             


Ala Met  Pro Glu Gly Tyr Val  Gln Glu Arg Thr Ile  Phe Phe Lys 
    1925                 1930                 1935             


Asp Asp  Gly Asn Tyr Lys Thr  Arg Ala Glu Val Lys  Phe Glu Gly 
    1940                 1945                 1950             


Asp Thr  Leu Val Asn Arg Ile  Glu Leu Lys Gly Ile  Asp Phe Lys 
    1955                 1960                 1965             


Glu Asp  Gly Asn Ile Leu Gly  His Lys Leu Glu Tyr  Asn Tyr Asn 
    1970                 1975                 1980             


Ser His  Asn Val Tyr Ile Met  Ala Asp Lys Gln Lys  Asn Gly Ile 
    1985                 1990                 1995             


Lys Val  Asn Phe Lys Ile Arg  His Asn Ile Glu Asp  Gly Ser Val 
    2000                 2005                 2010             


Gln Leu  Ala Asp His Tyr Gln  Gln Asn Thr Pro Ile  Gly Asp Gly 
    2015                 2020                 2025             


Pro Val  Leu Leu Pro Asp Asn  His Tyr Leu Ser Thr  Gln Ser Ala 
    2030                 2035                 2040             


Leu Ser  Lys Asp Pro Asn Glu  Lys Arg Asp His Met  Val Leu Leu 
    2045                 2050                 2055             


Glu Phe  Val Thr Ala Ala Gly  Ile Thr Leu Gly Met  Asp Glu Leu 
    2060                 2065                 2070             


Tyr Lys  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val 
    2075                 2080                 2085     


<210>  8
<211>  1627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


Ala Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Ser Gly Gly Ser  Pro Lys Lys 
    1610                 1615                 1620             


Lys Arg  Lys Val 
    1625         


<210>  9
<211>  1710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


Ala Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1610                 1615                 1620             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1625                 1630                 1635             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1640                 1645                 1650             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1655                 1660                 1665             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1670                 1675                 1680             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1685                 1690                 1695             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1700                 1705                 1710 


<210>  10
<211>  1710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1610                 1615                 1620             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1625                 1630                 1635             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1640                 1645                 1650             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1655                 1660                 1665             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1670                 1675                 1680             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1685                 1690                 1695             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1700                 1705                 1710 


<210>  11
<211>  1824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser 
225                 230                 235                 240 


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly 
                245                 250                 255     


Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
            260                 265                 270         


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
        275                 280                 285             


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
    290                 295                 300                 


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
305                 310                 315                 320 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
                325                 330                 335     


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
            340                 345                 350         


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
        355                 360                 365             


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
    370                 375                 380                 


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
385                 390                 395                 400 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
                405                 410                 415     


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
            420                 425                 430         


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
        435                 440                 445             


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
    450                 455                 460                 


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
465                 470                 475                 480 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
                485                 490                 495     


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
            500                 505                 510         


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
        515                 520                 525             


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
    530                 535                 540                 


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
545                 550                 555                 560 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
                565                 570                 575     


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
            580                 585                 590         


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
        595                 600                 605             


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
    610                 615                 620                 


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
625                 630                 635                 640 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
                645                 650                 655     


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
            660                 665                 670         


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
        675                 680                 685             


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
    690                 695                 700                 


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
705                 710                 715                 720 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
                725                 730                 735     


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
            740                 745                 750         


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
        755                 760                 765             


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
    770                 775                 780                 


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
785                 790                 795                 800 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
                805                 810                 815     


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
            820                 825                 830         


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
        835                 840                 845             


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
    850                 855                 860                 


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
865                 870                 875                 880 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
                885                 890                 895     


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
            900                 905                 910         


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
        915                 920                 925             


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
    930                 935                 940                 


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
945                 950                 955                 960 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
                965                 970                 975     


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
            980                 985                 990         


Ile Lys Lys Gly Ile Leu Gln Thr  Val Lys Val Val Asp  Glu Leu Val 
        995                 1000                 1005             


Lys Val  Met Gly Arg His Lys  Pro Glu Asn Ile Val  Ile Glu Met 
    1010                 1015                 1020             


Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly Gln Lys  Asn Ser Arg 
    1025                 1030                 1035             


Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile Lys Glu  Leu Gly Ser 
    1040                 1045                 1050             


Gln Ile  Leu Lys Glu His Pro  Val Glu Asn Thr Gln  Leu Gln Asn 
    1055                 1060                 1065             


Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn Gly Arg  Asp Met Tyr 
    1070                 1075                 1080             


Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu Ser Asp  Tyr Asp Val 
    1085                 1090                 1095             


Asp His  Ile Val Pro Gln Ser  Phe Leu Lys Asp Asp  Ser Ile Asp 
    1100                 1105                 1110             


Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp 
    1115                 1120                 1125             


Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp 
    1130                 1135                 1140             


Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp 
    1145                 1150                 1155             


Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser Glu  Leu Asp Lys 
    1160                 1165                 1170             


Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    1175                 1180                 1185             


Lys His  Val Ala Gln Ile Leu  Asp Ser Arg Met Asn  Thr Lys Tyr 
    1190                 1195                 1200             


Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val Lys Val  Ile Thr Leu 
    1205                 1210                 1215             


Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
    1220                 1225                 1230             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1235                 1240                 1245             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1250                 1255                 1260             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1265                 1270                 1275             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1280                 1285                 1290             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1295                 1300                 1305             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1310                 1315                 1320             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1325                 1330                 1335             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1340                 1345                 1350             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1355                 1360                 1365             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1370                 1375                 1380             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1385                 1390                 1395             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1400                 1405                 1410             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1415                 1420                 1425             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1430                 1435                 1440             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1445                 1450                 1455             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1460                 1465                 1470             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1475                 1480                 1485             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1490                 1495                 1500             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1505                 1510                 1515             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1520                 1525                 1530             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1535                 1540                 1545             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1550                 1555                 1560             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1565                 1570                 1575             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1580                 1585                 1590             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1595                 1600                 1605             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1610                 1615                 1620             


Gln Leu  Gly Gly Asp Ser Gly  Gly Ser Gly Gly Ser  Gly Gly Ser 
    1625                 1630                 1635             


Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu Thr Gly  Lys Gln Leu 
    1640                 1645                 1650             


Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro Glu Glu  Val Glu Glu 
    1655                 1660                 1665             


Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile Leu Val  His Thr Ala 
    1670                 1675                 1680             


Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met Leu Leu  Thr Ser Asp 
    1685                 1690                 1695             


Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val Ile Gln  Asp Ser Asn 
    1700                 1705                 1710             


Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly Gly Ser  Gly Gly Ser 
    1715                 1720                 1725             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1730                 1735                 1740             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1745                 1750                 1755             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1760                 1765                 1770             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1775                 1780                 1785             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1790                 1795                 1800             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1805                 1810                 1815             


Pro Lys  Lys Lys Arg Lys 
    1820                 


<210>  12
<211>  2012
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Ala Lys Pro Ala Lys Arg Ile Lys Ser Ala Ala Ala Ala Tyr Val Pro 
1               5                   10                  15      


Gln Asn Arg Asp Ala Val Ile Thr Asp Ile Lys Arg Ile Gly Asp Leu 
            20                  25                  30          


Gln Arg Glu Ala Ser Arg Leu Glu Thr Glu Met Asn Asp Ala Ile Ala 
        35                  40                  45              


Glu Ile Thr Glu Lys Phe Ala Ala Arg Ile Ala Pro Ile Lys Thr Asp 
    50                  55                  60                  


Ile Glu Thr Leu Ser Lys Gly Val Gln Gly Trp Cys Glu Ala Asn Arg 
65                  70                  75                  80  


Asp Glu Leu Thr Asn Gly Gly Lys Val Lys Thr Ala Asn Leu Val Thr 
                85                  90                  95      


Gly Asp Val Ser Trp Arg Val Arg Pro Pro Ser Val Ser Ile Arg Gly 
            100                 105                 110         


Met Asp Ala Val Met Glu Thr Leu Glu Arg Leu Gly Leu Gln Arg Phe 
        115                 120                 125             


Ile Arg Thr Lys Gln Glu Ile Asn Lys Glu Ala Ile Leu Leu Glu Pro 
    130                 135                 140                 


Lys Ala Val Ala Gly Val Ala Gly Ile Thr Val Lys Ser Gly Ile Glu 
145                 150                 155                 160 


Asp Phe Ser Ile Ile Pro Phe Glu Gln Glu Ala Gly Ile Ser Gly Ser 
                165                 170                 175     


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Ser Glu 
            180                 185                 190         


Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro 
        195                 200                 205             


His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr 
    210                 215                 220                 


Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg 
225                 230                 235                 240 


His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu 
                245                 250                 255     


Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile 
            260                 265                 270         


Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile 
        275                 280                 285             


Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile 
    290                 295                 300                 


Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg 
305                 310                 315                 320 


Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu 
                325                 330                 335     


Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu 
            340                 345                 350         


Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu 
        355                 360                 365             


Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu 
    370                 375                 380                 


Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser 
385                 390                 395                 400 


Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu 
                405                 410                 415     


Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly 
            420                 425                 430         


Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly 
        435                 440                 445             


Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
    450                 455                 460                 


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
465                 470                 475                 480 


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
                485                 490                 495     


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
            500                 505                 510         


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
        515                 520                 525             


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
    530                 535                 540                 


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
545                 550                 555                 560 


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
                565                 570                 575     


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
            580                 585                 590         


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
        595                 600                 605             


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
    610                 615                 620                 


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
625                 630                 635                 640 


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
                645                 650                 655     


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
            660                 665                 670         


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
        675                 680                 685             


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
    690                 695                 700                 


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
705                 710                 715                 720 


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
                725                 730                 735     


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
            740                 745                 750         


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
        755                 760                 765             


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
    770                 775                 780                 


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
785                 790                 795                 800 


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
                805                 810                 815     


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
            820                 825                 830         


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
        835                 840                 845             


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
    850                 855                 860                 


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
865                 870                 875                 880 


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
                885                 890                 895     


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
            900                 905                 910         


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
        915                 920                 925             


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
    930                 935                 940                 


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
945                 950                 955                 960 


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
                965                 970                 975     


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
            980                 985                 990         


Lys Lys Ala Ile Val Asp Leu Leu  Phe Lys Thr Asn Arg  Lys Val Thr 
        995                 1000                 1005             


Val Lys  Gln Leu Lys Glu Asp  Tyr Phe Lys Lys Ile  Glu Cys Phe 
    1010                 1015                 1020             


Asp Ser  Val Glu Ile Ser Gly  Val Glu Asp Arg Phe  Asn Ala Ser 
    1025                 1030                 1035             


Leu Gly  Thr Tyr His Asp Leu  Leu Lys Ile Ile Lys  Asp Lys Asp 
    1040                 1045                 1050             


Phe Leu  Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
    1055                 1060                 1065             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1070                 1075                 1080             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1085                 1090                 1095             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1100                 1105                 1110             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1115                 1120                 1125             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1130                 1135                 1140             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1145                 1150                 1155             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1160                 1165                 1170             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1175                 1180                 1185             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1190                 1195                 1200             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1205                 1210                 1215             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1220                 1225                 1230             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1235                 1240                 1245             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1250                 1255                 1260             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1265                 1270                 1275             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1280                 1285                 1290             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1295                 1300                 1305             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1310                 1315                 1320             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1325                 1330                 1335             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1340                 1345                 1350             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1355                 1360                 1365             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1370                 1375                 1380             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1385                 1390                 1395             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1400                 1405                 1410             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1415                 1420                 1425             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1430                 1435                 1440             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1445                 1450                 1455             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1460                 1465                 1470             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1475                 1480                 1485             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1490                 1495                 1500             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1505                 1510                 1515             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1520                 1525                 1530             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1535                 1540                 1545             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1550                 1555                 1560             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1565                 1570                 1575             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1580                 1585                 1590             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1595                 1600                 1605             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1610                 1615                 1620             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1625                 1630                 1635             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1640                 1645                 1650             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1655                 1660                 1665             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1670                 1675                 1680             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1685                 1690                 1695             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1700                 1705                 1710             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1715                 1720                 1725             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1730                 1735                 1740             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1745                 1750                 1755             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1760                 1765                 1770             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1775                 1780                 1785             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1790                 1795                 1800             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1805                 1810                 1815             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1820                 1825                 1830             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1835                 1840                 1845             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1850                 1855                 1860             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1865                 1870                 1875             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1880                 1885                 1890             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1895                 1900                 1905             


Leu Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser 
    1910                 1915                 1920             


Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu 
    1925                 1930                 1935             


Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn 
    1940                 1945                 1950             


Lys Pro  Glu Ser Asp Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser 
    1955                 1960                 1965             


Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr 
    1970                 1975                 1980             


Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys 
    1985                 1990                 1995             


Ile Lys  Met Leu Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys 
    2000                 2005                 2010         


<210>  13
<211>  1544
<212>  PRT
<213>  S. aureus

<400>  13

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser 
225                 230                 235                 240 


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly 
                245                 250                 255     


Ser Ser Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile 
            260                 265                 270         


Gly Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp 
        275                 280                 285             


Val Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn 
    290                 295                 300                 


Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg 
305                 310                 315                 320 


Arg Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn 
                325                 330                 335     


Leu Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala 
            340                 345                 350         


Arg Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala 
        355                 360                 365             


Ala Leu Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu 
    370                 375                 380                 


Val Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser 
385                 390                 395                 400 


Arg Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu 
                405                 410                 415     


Glu Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe 
            420                 425                 430         


Lys Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln 
        435                 440                 445             


Lys Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp 
    450                 455                 460                 


Leu Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser 
465                 470                 475                 480 


Pro Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly 
                485                 490                 495     


His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr 
            500                 505                 510         


Asn Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile 
        515                 520                 525             


Thr Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile 
    530                 535                 540                 


Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile 
545                 550                 555                 560 


Ala Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val 
                565                 570                 575     


Thr Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp 
            580                 585                 590         


Ile Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu 
        595                 600                 605             


Leu Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp 
    610                 615                 620                 


Ile Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu 
625                 630                 635                 640 


Ile Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu 
                645                 650                 655     


Ser Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn 
            660                 665                 670         


Asp Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys 
        675                 680                 685             


Val Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp 
    690                 695                 700                 


Phe Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys 
705                 710                 715                 720 


Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile 
                725                 730                 735     


Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile 
            740                 745                 750         


Asn Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu 
        755                 760                 765             


Ile Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys 
    770                 775                 780                 


Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu 
785                 790                 795                 800 


Ala Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val 
                805                 810                 815     


Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn 
            820                 825                 830         


Lys Val Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr 
        835                 840                 845             


Pro Phe Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr 
    850                 855                 860                 


Phe Lys Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser 
865                 870                 875                 880 


Lys Thr Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe 
                885                 890                 895     


Ser Val Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr 
            900                 905                 910         


Ala Thr Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn 
        915                 920                 925             


Asn Leu Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe 
    930                 935                 940                 


Leu Arg Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys 
945                 950                 955                 960 


His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe 
                965                 970                 975     


Lys Glu Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln 
            980                 985                 990         


Met Phe Glu Glu Lys Gln Ala Glu  Ser Met Pro Glu Ile  Glu Thr Glu 
        995                 1000                 1005             


Gln Glu  Tyr Lys Glu Ile Phe  Ile Thr Pro His Gln  Ile Lys His 
    1010                 1015                 1020             


Ile Lys  Asp Phe Lys Asp Tyr  Lys Tyr Ser His Arg  Val Asp Lys 
    1025                 1030                 1035             


Lys Pro  Asn Arg Glu Leu Ile  Asn Asp Thr Leu Tyr  Ser Thr Arg 
    1040                 1045                 1050             


Lys Asp  Asp Lys Gly Asn Thr  Leu Ile Val Asn Asn  Leu Asn Gly 
    1055                 1060                 1065             


Leu Tyr  Asp Lys Asp Asn Asp  Lys Leu Lys Lys Leu  Ile Asn Lys 
    1070                 1075                 1080             


Ser Pro  Glu Lys Leu Leu Met  Tyr His His Asp Pro  Gln Thr Tyr 
    1085                 1090                 1095             


Gln Lys  Leu Lys Leu Ile Met  Glu Gln Tyr Gly Asp  Glu Lys Asn 
    1100                 1105                 1110             


Pro Leu  Tyr Lys Tyr Tyr Glu  Glu Thr Gly Asn Tyr  Leu Thr Lys 
    1115                 1120                 1125             


Tyr Ser  Lys Lys Asp Asn Gly  Pro Val Ile Lys Lys  Ile Lys Tyr 
    1130                 1135                 1140             


Tyr Gly  Asn Lys Leu Asn Ala  His Leu Asp Ile Thr  Asp Asp Tyr 
    1145                 1150                 1155             


Pro Asn  Ser Arg Asn Lys Val  Val Lys Leu Ser Leu  Lys Pro Tyr 
    1160                 1165                 1170             


Arg Phe  Asp Val Tyr Leu Asp  Asn Gly Val Tyr Lys  Phe Val Thr 
    1175                 1180                 1185             


Val Lys  Asn Leu Asp Val Ile  Lys Lys Glu Asn Tyr  Tyr Glu Val 
    1190                 1195                 1200             


Asn Ser  Lys Cys Tyr Glu Glu  Ala Lys Lys Leu Lys  Lys Ile Ser 
    1205                 1210                 1215             


Asn Gln  Ala Glu Phe Ile Ala  Ser Phe Tyr Asn Asn  Asp Leu Ile 
    1220                 1225                 1230             


Lys Ile  Asn Gly Glu Leu Tyr  Arg Val Ile Gly Val  Asn Asn Asp 
    1235                 1240                 1245             


Leu Leu  Asn Arg Ile Glu Val  Asn Met Ile Asp Ile  Thr Tyr Arg 
    1250                 1255                 1260             


Glu Tyr  Leu Glu Asn Met Asn  Asp Lys Arg Pro Pro  Arg Ile Ile 
    1265                 1270                 1275             


Lys Thr  Ile Ala Ser Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr 
    1280                 1285                 1290             


Asp Ile  Leu Gly Asn Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro 
    1295                 1300                 1305             


Gln Ile  Ile Lys Lys Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1310                 1315                 1320             


Ser Ser  Asp Tyr Lys Asp His  Asp Gly Asp Tyr Lys  Asp His Asp 
    1325                 1330                 1335             


Ile Asp  Tyr Lys Asp Asp Asp  Asp Lys Ser Gly Gly  Ser Gly Gly 
    1340                 1345                 1350             


Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr 
    1355                 1360                 1365             


Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu 
    1370                 1375                 1380             


Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu 
    1385                 1390                 1395             


Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu 
    1400                 1405                 1410             


Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile 
    1415                 1420                 1425             


Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly 
    1430                 1435                 1440             


Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu 
    1445                 1450                 1455             


Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met 
    1460                 1465                 1470             


Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser 
    1475                 1480                 1485             


Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn 
    1490                 1495                 1500             


Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala 
    1505                 1510                 1515             


Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu 
    1520                 1525                 1530             


Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val 
    1535                 1540                 


<210>  14
<211>  1733
<212>  PRT
<213>  S. aureus

<400>  14

Met Ala Lys Pro Ala Lys Arg Ile Lys Ser Ala Ala Ala Ala Tyr Val 
1               5                   10                  15      


Pro Gln Asn Arg Asp Ala Val Ile Thr Asp Ile Lys Arg Ile Gly Asp 
            20                  25                  30          


Leu Gln Arg Glu Ala Ser Arg Leu Glu Thr Glu Met Asn Asp Ala Ile 
        35                  40                  45              


Ala Glu Ile Thr Glu Lys Phe Ala Ala Arg Ile Ala Pro Ile Lys Thr 
    50                  55                  60                  


Asp Ile Glu Thr Leu Ser Lys Gly Val Gln Gly Trp Cys Glu Ala Asn 
65                  70                  75                  80  


Arg Asp Glu Leu Thr Asn Gly Gly Lys Val Lys Thr Ala Asn Leu Val 
                85                  90                  95      


Thr Gly Asp Val Ser Trp Arg Val Arg Pro Pro Ser Val Ser Ile Arg 
            100                 105                 110         


Gly Met Asp Ala Val Met Glu Thr Leu Glu Arg Leu Gly Leu Gln Arg 
        115                 120                 125             


Phe Ile Arg Thr Lys Gln Glu Ile Asn Lys Glu Ala Ile Leu Leu Glu 
    130                 135                 140                 


Pro Lys Ala Val Ala Gly Val Ala Gly Ile Thr Val Lys Ser Gly Ile 
145                 150                 155                 160 


Glu Asp Phe Ser Ile Ile Pro Phe Glu Gln Glu Ala Gly Ile Ser Gly 
                165                 170                 175     


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Ser 
            180                 185                 190         


Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu 
        195                 200                 205             


Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu 
    210                 215                 220                 


Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp 
225                 230                 235                 240 


Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn Phe Ile 
                245                 250                 255     


Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser 
            260                 265                 270         


Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala 
        275                 280                 285             


Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr 
    290                 295                 300                 


Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln Gly Leu 
305                 310                 315                 320 


Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln 
                325                 330                 335     


Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn 
            340                 345                 350         


Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val 
        355                 360                 365             


Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile 
    370                 375                 380                 


Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln 
385                 390                 395                 400 


Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly 
                405                 410                 415     


Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro 
            420                 425                 430         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly 
        435                 440                 445             


Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr 
    450                 455                 460                 


Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp 
465                 470                 475                 480 


Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly 
                485                 490                 495     


Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His 
            500                 505                 510         


Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr 
        515                 520                 525             


Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys 
    530                 535                 540                 


Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu 
545                 550                 555                 560 


His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu 
                565                 570                 575     


Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser 
            580                 585                 590         


Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu 
        595                 600                 605             


Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser 
    610                 615                 620                 


Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr 
625                 630                 635                 640 


His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu 
                645                 650                 655     


Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly 
            660                 665                 670         


Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr 
        675                 680                 685             


Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp 
    690                 695                 700                 


Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp 
705                 710                 715                 720 


Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn 
                725                 730                 735     


Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu 
            740                 745                 750         


Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr 
        755                 760                 765             


Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp 
    770                 775                 780                 


Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln 
785                 790                 795                 800 


Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu 
                805                 810                 815     


Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln 
            820                 825                 830         


Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys 
        835                 840                 845             


Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln 
    850                 855                 860                 


Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu 
865                 870                 875                 880 


Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu 
                885                 890                 895     


Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn 
            900                 905                 910         


Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu 
        915                 920                 925             


Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met 
    930                 935                 940                 


Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg 
945                 950                 955                 960 


Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu 
                965                 970                 975     


His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro 
            980                 985                 990         


Leu Glu Asp Leu Leu Asn Asn Pro  Phe Asn Tyr Glu Val  Asp His Ile 
        995                 1000                 1005             


Ile Pro  Arg Ser Val Ser Phe  Asp Asn Ser Phe Asn  Asn Lys Val 
    1010                 1015                 1020             


Leu Val  Lys Gln Glu Glu Asn  Ser Lys Lys Gly Asn  Arg Thr Pro 
    1025                 1030                 1035             


Phe Gln  Tyr Leu Ser Ser Ser  Asp Ser Lys Ile Ser  Tyr Glu Thr 
    1040                 1045                 1050             


Phe Lys  Lys His Ile Leu Asn  Leu Ala Lys Gly Lys  Gly Arg Ile 
    1055                 1060                 1065             


Ser Lys  Thr Lys Lys Glu Tyr  Leu Leu Glu Glu Arg  Asp Ile Asn 
    1070                 1075                 1080             


Arg Phe  Ser Val Gln Lys Asp  Phe Ile Asn Arg Asn  Leu Val Asp 
    1085                 1090                 1095             


Thr Arg  Tyr Ala Thr Arg Gly  Leu Met Asn Leu Leu  Arg Ser Tyr 
    1100                 1105                 1110             


Phe Arg  Val Asn Asn Leu Asp  Val Lys Val Lys Ser  Ile Asn Gly 
    1115                 1120                 1125             


Gly Phe  Thr Ser Phe Leu Arg  Arg Lys Trp Lys Phe  Lys Lys Glu 
    1130                 1135                 1140             


Arg Asn  Lys Gly Tyr Lys His  His Ala Glu Asp Ala  Leu Ile Ile 
    1145                 1150                 1155             


Ala Asn  Ala Asp Phe Ile Phe  Lys Glu Trp Lys Lys  Leu Asp Lys 
    1160                 1165                 1170             


Ala Lys  Lys Val Met Glu Asn  Gln Met Phe Glu Glu  Lys Gln Ala 
    1175                 1180                 1185             


Glu Ser  Met Pro Glu Ile Glu  Thr Glu Gln Glu Tyr  Lys Glu Ile 
    1190                 1195                 1200             


Phe Ile  Thr Pro His Gln Ile  Lys His Ile Lys Asp  Phe Lys Asp 
    1205                 1210                 1215             


Tyr Lys  Tyr Ser His Arg Val  Asp Lys Lys Pro Asn  Arg Glu Leu 
    1220                 1225                 1230             


Ile Asn  Asp Thr Leu Tyr Ser  Thr Arg Lys Asp Asp  Lys Gly Asn 
    1235                 1240                 1245             


Thr Leu  Ile Val Asn Asn Leu  Asn Gly Leu Tyr Asp  Lys Asp Asn 
    1250                 1255                 1260             


Asp Lys  Leu Lys Lys Leu Ile  Asn Lys Ser Pro Glu  Lys Leu Leu 
    1265                 1270                 1275             


Met Tyr  His His Asp Pro Gln  Thr Tyr Gln Lys Leu  Lys Leu Ile 
    1280                 1285                 1290             


Met Glu  Gln Tyr Gly Asp Glu  Lys Asn Pro Leu Tyr  Lys Tyr Tyr 
    1295                 1300                 1305             


Glu Glu  Thr Gly Asn Tyr Leu  Thr Lys Tyr Ser Lys  Lys Asp Asn 
    1310                 1315                 1320             


Gly Pro  Val Ile Lys Lys Ile  Lys Tyr Tyr Gly Asn  Lys Leu Asn 
    1325                 1330                 1335             


Ala His  Leu Asp Ile Thr Asp  Asp Tyr Pro Asn Ser  Arg Asn Lys 
    1340                 1345                 1350             


Val Val  Lys Leu Ser Leu Lys  Pro Tyr Arg Phe Asp  Val Tyr Leu 
    1355                 1360                 1365             


Asp Asn  Gly Val Tyr Lys Phe  Val Thr Val Lys Asn  Leu Asp Val 
    1370                 1375                 1380             


Ile Lys  Lys Glu Asn Tyr Tyr  Glu Val Asn Ser Lys  Cys Tyr Glu 
    1385                 1390                 1395             


Glu Ala  Lys Lys Leu Lys Lys  Ile Ser Asn Gln Ala  Glu Phe Ile 
    1400                 1405                 1410             


Ala Ser  Phe Tyr Asn Asn Asp  Leu Ile Lys Ile Asn  Gly Glu Leu 
    1415                 1420                 1425             


Tyr Arg  Val Ile Gly Val Asn  Asn Asp Leu Leu Asn  Arg Ile Glu 
    1430                 1435                 1440             


Val Asn  Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
    1445                 1450                 1455             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1460                 1465                 1470             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1475                 1480                 1485             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1490                 1495                 1500             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Ser Ser Asp  Tyr Lys Asp 
    1505                 1510                 1515             


His Asp  Gly Asp Tyr Lys Asp  His Asp Ile Asp Tyr  Lys Asp Asp 
    1520                 1525                 1530             


Asp Asp  Lys Ser Gly Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn 
    1535                 1540                 1545             


Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile 
    1550                 1555                 1560             


Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu Val Glu  Glu Val Ile 
    1565                 1570                 1575             


Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp 
    1580                 1585                 1590             


Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro 
    1595                 1600                 1605             


Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu 
    1610                 1615                 1620             


Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1625                 1630                 1635             


Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln 
    1640                 1645                 1650             


Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu 
    1655                 1660                 1665             


Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp Ile Leu  Val His Thr 
    1670                 1675                 1680             


Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser 
    1685                 1690                 1695             


Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser 
    1700                 1705                 1710             


Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser Gly Gly  Ser Pro Lys 
    1715                 1720                 1725             


Lys Lys  Arg Lys Val 
    1730             


<210>  15
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Asn Gly Gly Asn Gly 
1               5   


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Asn Asn Ala Gly Ala Ala Trp 
1               5           


<210>  18
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  19
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  20
<211>  1367
<212>  PRT
<213>  S. pyogenes

<400>  20

Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  21
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu u                                                 81


<210>  22

<400>  22
000

<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  24
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
            20                  25                  30  


<210>  25
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val 
        


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val 
    


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  28
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10  


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Ser Gly Gly Ser 
1               


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
agcaagtatg atgagcaagc                                                   20


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
aaaacagatg ctctgagaaa ggc                                               23


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
taggaacagc tccggtctac a                                                 21


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
aatgcctcgc cctgcttcgg                                                   20


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
ccaatacaga gaagtgctta aagg                                              24


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
cttggaggct ttgctcattt ct                                                22


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
cccatcagtg tgctgtattc agg                                               23


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
ggccttcttt gtctcttttg                                                   20


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
aacaggctct gaaattgtgg c                                                 21


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
gctggcctca taaaatgagt tag                                               23


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
gttctggcca gggcaatcag                                                   20


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
cctgagactt tgctgaagtt gc                                                22


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
aataccaccc tcactgggct                                                   20


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
cagattggaa acaagaggtc c                                                 21


<210>  45
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
tttatctgat tacgacgtcg atgccattgt accccaatcc tttttg                      46


<210>  46
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
caaaaaggat tggggtacaa tggcatcgac gtcgtaatca gataaa                      46


<210>  47
<211>  20
<212>  DNA
<213>  S. pyogenes

<400>  47
gagacgatta atgcgtctcg                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
aattatggag tatgtgtctg                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
gatgacaggc aggggcaccg                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
gaacacaaag catagactgc                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
aacgagacag aaagtcaaca                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
tcagtttcca tgtagttgag                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
tatgtaccca gtagtcattc                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
attctaccag aggtacaagg                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
ttgaaccagc cttgcatccc                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
gggtattcaa ttaggaaaag                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
gactcccaca cattaataat                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
gcttaggtaa acaaagcagc                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
attttggaat aggtgtggtg                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
attcagtatg atattggctg                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
cctaggaatc caacttacaa                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
aaaaagagtc caggaccaga                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
caggcgtgag ccaccgcgcc                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  S. aureus

<400>  64
gagacgatta atgcgtctcg                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
gaggcacatc caacagttag                                                   20


<210>  66
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
ctttccctac acgacgctct tccgatct                                          28


<210>  67
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
ggagttcaga cgtgtgctct tccgatct                                          28


<210>  68
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
agactcccac acattaataa tggg                                              24


<210>  69
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
tgatttgggg tggagagttc tg                                                22


<210>  70
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
agtgcaatca aactagaact cagg                                              24


<210>  71
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
ccctctacac actgctttga atg                                               23


<210>  72
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72
agtgcaatca aactagaact cagg                                              24


<210>  73
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
ccctctacac actgctttga atg                                               23


<210>  74
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74
aagagtccag gaccagatgg at                                                22


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
cccggctttg gtatcagaat g                                                 21


<210>  76
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
cttatccacc atgatcaagt ggg                                               23


<210>  77
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
ctgcatctat tgagataatc atgtgg                                            26


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
gttctggcca gggcaatcag                                                   20


<210>  79
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
cctgagactt tgctgaagtt gc                                                22


<210>  80
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
aactgcaagg cggcaacgag                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
agaggtggag cctacagagg                                                   20


<210>  82
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
ccaatacagg agcacccaga tt                                                22


<210>  83
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
tgatttgggg tggagagttc                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
cagaactctc caccccaaat                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85
cctgagttct agtttgattg                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
ccacatgatt atctcaatag                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87
gagggcatcc ctgtcttgtg                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
gcaacttcag caaagtctca                                                   20


<210>  89
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89
gtagttctcc ttgaagaggt cc                                                22


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
ccaatacagg agcacccaga tt                                                22


<210>  91
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91
ccctctacac actgctttga atg                                               23


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92
ccacatgatt atctcaatag                                                   20


<210>  93
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93
gtagttctcc ttgaagaggt cc                                                22


<210>  94
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94
cagaactctc caccccaaat c                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95
cccggctttg gtatcagaat g                                                 21


<210>  96
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96
cagaactctc caccccaaat c                                                 21


<210>  97
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97
ccctctacac actgctttga atg                                               23


<210>  98
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98
aataccaccc tcactgggct                                                   20


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99
cagattggaa acaagaggtc c                                                 21


<210>  100
<211>  1052
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100

Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile Gln 
    50                  55                  60                  


Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His Ser 
65                  70                  75                  80  


Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu Ala 
            100                 105                 110         


Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr Gly 
        115                 120                 125             


Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu 
    130                 135                 140                 


Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp 
145                 150                 155                 160 


Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val 
                165                 170                 175     


Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln Leu 
            180                 185                 190         


Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg 
        195                 200                 205             


Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp 
    210                 215                 220                 


Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro 
225                 230                 235                 240 


Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn 
                245                 250                 255     


Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn Glu 
            260                 265                 270         


Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys 
        275                 280                 285             


Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu Val 
    290                 295                 300                 


Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro 
305                 310                 315                 320 


Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr Ala 
                325                 330                 335     


Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys 
            340                 345                 350         


Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr 
        355                 360                 365             


Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn 
    370                 375                 380                 


Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile Asn 
385                 390                 395                 400 


Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala Ile 
                405                 410                 415     


Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln Gln 
            420                 425                 430         


Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro Val 
        435                 440                 445             


Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile Ile 
    450                 455                 460                 


Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu 
465                 470                 475                 480 


Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys Arg 
                485                 490                 495     


Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly 
            500                 505                 510         


Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp Met 
        515                 520                 525             


Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp 
    530                 535                 540                 


Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro Arg 
545                 550                 555                 560 


Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys Gln 
                565                 570                 575     


Glu Glu Ala Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser 
            580                 585                 590         


Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile Leu 
        595                 600                 605             


Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu Tyr 
    610                 615                 620                 


Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp Phe 
625                 630                 635                 640 


Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu Met 
                645                 650                 655     


Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys Val 
            660                 665                 670         


Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp Lys 
        675                 680                 685             


Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp Ala 
    690                 695                 700                 


Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys Leu 
705                 710                 715                 720 


Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys Gln 
                725                 730                 735     


Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu Ile 
            740                 745                 750         


Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp Tyr 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu Ile 
785                 790                 795                 800 


Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu Lys 
                805                 810                 815     


Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His Asp 
            820                 825                 830         


Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly Asp 
        835                 840                 845             


Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile Lys 
865                 870                 875                 880 


Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp Tyr 
                885                 890                 895     


Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val Lys 
        915                 920                 925             


Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser Lys 
    930                 935                 940                 


Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala Glu 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly Glu 
                965                 970                 975     


Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile Glu 
            980                 985                 990         


Val Asn Met Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
        995                 1000                 1005             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1010                 1015                 1020             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1025                 1030                 1035             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1040                 1045                 1050         


<210>  101
<211>  1052
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101

Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile Gln 
    50                  55                  60                  


Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His Ser 
65                  70                  75                  80  


Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu Ala 
            100                 105                 110         


Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr Gly 
        115                 120                 125             


Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu 
    130                 135                 140                 


Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp 
145                 150                 155                 160 


Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val 
                165                 170                 175     


Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln Leu 
            180                 185                 190         


Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg 
        195                 200                 205             


Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp 
    210                 215                 220                 


Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro 
225                 230                 235                 240 


Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn 
                245                 250                 255     


Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn Glu 
            260                 265                 270         


Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys 
        275                 280                 285             


Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu Val 
    290                 295                 300                 


Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro 
305                 310                 315                 320 


Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr Ala 
                325                 330                 335     


Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys 
            340                 345                 350         


Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr 
        355                 360                 365             


Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn 
    370                 375                 380                 


Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile Asn 
385                 390                 395                 400 


Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala Ile 
                405                 410                 415     


Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln Gln 
            420                 425                 430         


Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro Val 
        435                 440                 445             


Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile Ile 
    450                 455                 460                 


Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu 
465                 470                 475                 480 


Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys Arg 
                485                 490                 495     


Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly 
            500                 505                 510         


Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp Met 
        515                 520                 525             


Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp 
    530                 535                 540                 


Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro Arg 
545                 550                 555                 560 


Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys Gln 
                565                 570                 575     


Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser 
            580                 585                 590         


Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile Leu 
        595                 600                 605             


Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu Tyr 
    610                 615                 620                 


Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp Phe 
625                 630                 635                 640 


Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu Met 
                645                 650                 655     


Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys Val 
            660                 665                 670         


Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp Lys 
        675                 680                 685             


Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp Ala 
    690                 695                 700                 


Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys Leu 
705                 710                 715                 720 


Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys Gln 
                725                 730                 735     


Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu Ile 
            740                 745                 750         


Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp Tyr 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu Ile 
785                 790                 795                 800 


Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu Lys 
                805                 810                 815     


Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His Asp 
            820                 825                 830         


Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly Asp 
        835                 840                 845             


Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile Lys 
865                 870                 875                 880 


Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp Tyr 
                885                 890                 895     


Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val Lys 
        915                 920                 925             


Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser Lys 
    930                 935                 940                 


Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala Glu 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly Glu 
                965                 970                 975     


Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile Glu 
            980                 985                 990         


Val Asn Met Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
        995                 1000                 1005             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1010                 1015                 1020             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1025                 1030                 1035             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1040                 1045                 1050         


<210>  102
<211>  1052
<212>  PRT
<213>  S. aureus

<400>  102

Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile Gln 
    50                  55                  60                  


Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His Ser 
65                  70                  75                  80  


Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu Ala 
            100                 105                 110         


Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr Gly 
        115                 120                 125             


Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu 
    130                 135                 140                 


Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp 
145                 150                 155                 160 


Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val 
                165                 170                 175     


Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln Leu 
            180                 185                 190         


Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg 
        195                 200                 205             


Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp 
    210                 215                 220                 


Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro 
225                 230                 235                 240 


Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn 
                245                 250                 255     


Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn Glu 
            260                 265                 270         


Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys 
        275                 280                 285             


Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu Val 
    290                 295                 300                 


Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro 
305                 310                 315                 320 


Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr Ala 
                325                 330                 335     


Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys 
            340                 345                 350         


Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr 
        355                 360                 365             


Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn 
    370                 375                 380                 


Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile Asn 
385                 390                 395                 400 


Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala Ile 
                405                 410                 415     


Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln Gln 
            420                 425                 430         


Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro Val 
        435                 440                 445             


Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile Ile 
    450                 455                 460                 


Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu 
465                 470                 475                 480 


Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys Arg 
                485                 490                 495     


Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly 
            500                 505                 510         


Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp Met 
        515                 520                 525             


Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp 
    530                 535                 540                 


Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro Arg 
545                 550                 555                 560 


Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys Gln 
                565                 570                 575     


Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser 
            580                 585                 590         


Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile Leu 
        595                 600                 605             


Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu Tyr 
    610                 615                 620                 


Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp Phe 
625                 630                 635                 640 


Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu Met 
                645                 650                 655     


Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys Val 
            660                 665                 670         


Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp Lys 
        675                 680                 685             


Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp Ala 
    690                 695                 700                 


Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys Leu 
705                 710                 715                 720 


Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys Gln 
                725                 730                 735     


Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu Ile 
            740                 745                 750         


Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp Tyr 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu Ile 
785                 790                 795                 800 


Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu Lys 
                805                 810                 815     


Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His Asp 
            820                 825                 830         


Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly Asp 
        835                 840                 845             


Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile Lys 
865                 870                 875                 880 


Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp Tyr 
                885                 890                 895     


Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val Lys 
        915                 920                 925             


Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser Lys 
    930                 935                 940                 


Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala Glu 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly Glu 
                965                 970                 975     


Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile Glu 
            980                 985                 990         


Val Asn Met Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
        995                 1000                 1005             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1010                 1015                 1020             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1025                 1030                 1035             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1040                 1045                 1050         


<210>  103

<400>  103
000

<210>  104
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104

Met Glu Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Glu Tyr Pro Tyr 
1               5                   10                  15      


Asp Val Pro Asp Tyr Ala Ala Glu Tyr Pro Tyr Asp Val Pro Asp Tyr 
            20                  25                  30          


Ala Ala Lys Leu Glu 
        35          


<210>  105
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  105

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
        35                  40                  45              


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp 
                165         


<210>  106
<211>  1775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  Ala Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    1760                 1765                 1770             


Lys Val  
    1775 


<210>  107
<211>  1824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser 
225                 230                 235                 240 


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly 
                245                 250                 255     


Ser Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
            260                 265                 270         


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
        275                 280                 285             


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
    290                 295                 300                 


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
305                 310                 315                 320 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
                325                 330                 335     


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
            340                 345                 350         


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
        355                 360                 365             


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
    370                 375                 380                 


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
385                 390                 395                 400 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
                405                 410                 415     


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
            420                 425                 430         


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
        435                 440                 445             


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
    450                 455                 460                 


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
465                 470                 475                 480 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
                485                 490                 495     


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
            500                 505                 510         


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
        515                 520                 525             


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
    530                 535                 540                 


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
545                 550                 555                 560 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
                565                 570                 575     


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
            580                 585                 590         


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
        595                 600                 605             


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
    610                 615                 620                 


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
625                 630                 635                 640 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
                645                 650                 655     


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
            660                 665                 670         


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
        675                 680                 685             


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
    690                 695                 700                 


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
705                 710                 715                 720 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
                725                 730                 735     


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
            740                 745                 750         


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
        755                 760                 765             


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
    770                 775                 780                 


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
785                 790                 795                 800 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
                805                 810                 815     


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
            820                 825                 830         


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
        835                 840                 845             


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
    850                 855                 860                 


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
865                 870                 875                 880 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
                885                 890                 895     


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
            900                 905                 910         


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
        915                 920                 925             


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
    930                 935                 940                 


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
945                 950                 955                 960 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
                965                 970                 975     


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
            980                 985                 990         


Ile Lys Lys Gly Ile Leu Gln Thr  Val Lys Val Val Asp  Glu Leu Val 
        995                 1000                 1005             


Lys Val  Met Gly Arg His Lys  Pro Glu Asn Ile Val  Ile Glu Met 
    1010                 1015                 1020             


Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly Gln Lys  Asn Ser Arg 
    1025                 1030                 1035             


Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile Lys Glu  Leu Gly Ser 
    1040                 1045                 1050             


Gln Ile  Leu Lys Glu His Pro  Val Glu Asn Thr Gln  Leu Gln Asn 
    1055                 1060                 1065             


Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn Gly Arg  Asp Met Tyr 
    1070                 1075                 1080             


Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu Ser Asp  Tyr Asp Val 
    1085                 1090                 1095             


Asp Ala  Ile Val Pro Gln Ser  Phe Leu Lys Asp Asp  Ser Ile Asp 
    1100                 1105                 1110             


Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp 
    1115                 1120                 1125             


Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp 
    1130                 1135                 1140             


Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp 
    1145                 1150                 1155             


Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser Glu  Leu Asp Lys 
    1160                 1165                 1170             


Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    1175                 1180                 1185             


Lys His  Val Ala Gln Ile Leu  Asp Ser Arg Met Asn  Thr Lys Tyr 
    1190                 1195                 1200             


Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val Lys Val  Ile Thr Leu 
    1205                 1210                 1215             


Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
    1220                 1225                 1230             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1235                 1240                 1245             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1250                 1255                 1260             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1265                 1270                 1275             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1280                 1285                 1290             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1295                 1300                 1305             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1310                 1315                 1320             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1325                 1330                 1335             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1340                 1345                 1350             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1355                 1360                 1365             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1370                 1375                 1380             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1385                 1390                 1395             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1400                 1405                 1410             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1415                 1420                 1425             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1430                 1435                 1440             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1445                 1450                 1455             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1460                 1465                 1470             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1475                 1480                 1485             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1490                 1495                 1500             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1505                 1510                 1515             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1520                 1525                 1530             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1535                 1540                 1545             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1550                 1555                 1560             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1565                 1570                 1575             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1580                 1585                 1590             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1595                 1600                 1605             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1610                 1615                 1620             


Gln Leu  Gly Gly Asp Ser Gly  Gly Ser Gly Gly Ser  Gly Gly Ser 
    1625                 1630                 1635             


Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu Thr Gly  Lys Gln Leu 
    1640                 1645                 1650             


Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro Glu Glu  Val Glu Glu 
    1655                 1660                 1665             


Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile Leu Val  His Thr Ala 
    1670                 1675                 1680             


Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met Leu Leu  Thr Ser Asp 
    1685                 1690                 1695             


Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val Ile Gln  Asp Ser Asn 
    1700                 1705                 1710             


Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly Gly Ser  Gly Gly Ser 
    1715                 1720                 1725             


Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly 
    1730                 1735                 1740             


Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu 
    1745                 1750                 1755             


Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val 
    1760                 1765                 1770             


His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu 
    1775                 1780                 1785             


Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln 
    1790                 1795                 1800             


Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser 
    1805                 1810                 1815             


Pro Lys  Lys Lys Arg Lys 
    1820                 


<210>  108
<211>  2012
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  108

Ala Lys Pro Ala Lys Arg Ile Lys Ser Ala Ala Ala Ala Tyr Val Pro 
1               5                   10                  15      


Gln Asn Arg Asp Ala Val Ile Thr Asp Ile Lys Arg Ile Gly Asp Leu 
            20                  25                  30          


Gln Arg Glu Ala Ser Arg Leu Glu Thr Glu Met Asn Asp Ala Ile Ala 
        35                  40                  45              


Glu Ile Thr Glu Lys Phe Ala Ala Arg Ile Ala Pro Ile Lys Thr Asp 
    50                  55                  60                  


Ile Glu Thr Leu Ser Lys Gly Val Gln Gly Trp Cys Glu Ala Asn Arg 
65                  70                  75                  80  


Asp Glu Leu Thr Asn Gly Gly Lys Val Lys Thr Ala Asn Leu Val Thr 
                85                  90                  95      


Gly Asp Val Ser Trp Arg Val Arg Pro Pro Ser Val Ser Ile Arg Gly 
            100                 105                 110         


Met Asp Ala Val Met Glu Thr Leu Glu Arg Leu Gly Leu Gln Arg Phe 
        115                 120                 125             


Ile Arg Thr Lys Gln Glu Ile Asn Lys Glu Ala Ile Leu Leu Glu Pro 
    130                 135                 140                 


Lys Ala Val Ala Gly Val Ala Gly Ile Thr Val Lys Ser Gly Ile Glu 
145                 150                 155                 160 


Asp Phe Ser Ile Ile Pro Phe Glu Gln Glu Ala Gly Ile Ser Gly Ser 
                165                 170                 175     


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Ser Glu 
            180                 185                 190         


Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro 
        195                 200                 205             


His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr 
    210                 215                 220                 


Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg 
225                 230                 235                 240 


His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu 
                245                 250                 255     


Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile 
            260                 265                 270         


Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile 
        275                 280                 285             


Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile 
    290                 295                 300                 


Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg 
305                 310                 315                 320 


Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu 
                325                 330                 335     


Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu 
            340                 345                 350         


Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu 
        355                 360                 365             


Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu 
    370                 375                 380                 


Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser 
385                 390                 395                 400 


Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu 
                405                 410                 415     


Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly 
            420                 425                 430         


Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly 
        435                 440                 445             


Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
    450                 455                 460                 


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
465                 470                 475                 480 


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
                485                 490                 495     


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
            500                 505                 510         


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
        515                 520                 525             


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
    530                 535                 540                 


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
545                 550                 555                 560 


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
                565                 570                 575     


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
            580                 585                 590         


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
        595                 600                 605             


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
    610                 615                 620                 


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
625                 630                 635                 640 


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
                645                 650                 655     


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
            660                 665                 670         


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
        675                 680                 685             


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
    690                 695                 700                 


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
705                 710                 715                 720 


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
                725                 730                 735     


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
            740                 745                 750         


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
        755                 760                 765             


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
    770                 775                 780                 


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
785                 790                 795                 800 


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
                805                 810                 815     


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
            820                 825                 830         


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
        835                 840                 845             


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
    850                 855                 860                 


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
865                 870                 875                 880 


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
                885                 890                 895     


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
            900                 905                 910         


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
        915                 920                 925             


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
    930                 935                 940                 


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
945                 950                 955                 960 


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
                965                 970                 975     


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
            980                 985                 990         


Lys Lys Ala Ile Val Asp Leu Leu  Phe Lys Thr Asn Arg  Lys Val Thr 
        995                 1000                 1005             


Val Lys  Gln Leu Lys Glu Asp  Tyr Phe Lys Lys Ile  Glu Cys Phe 
    1010                 1015                 1020             


Asp Ser  Val Glu Ile Ser Gly  Val Glu Asp Arg Phe  Asn Ala Ser 
    1025                 1030                 1035             


Leu Gly  Thr Tyr His Asp Leu  Leu Lys Ile Ile Lys  Asp Lys Asp 
    1040                 1045                 1050             


Phe Leu  Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
    1055                 1060                 1065             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1070                 1075                 1080             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1085                 1090                 1095             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1100                 1105                 1110             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1115                 1120                 1125             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1130                 1135                 1140             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1145                 1150                 1155             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1160                 1165                 1170             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1175                 1180                 1185             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1190                 1195                 1200             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1205                 1210                 1215             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1220                 1225                 1230             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1235                 1240                 1245             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1250                 1255                 1260             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1265                 1270                 1275             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp Ala Ile Val  Pro Gln Ser 
    1280                 1285                 1290             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1295                 1300                 1305             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1310                 1315                 1320             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1325                 1330                 1335             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1340                 1345                 1350             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1355                 1360                 1365             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1370                 1375                 1380             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1385                 1390                 1395             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1400                 1405                 1410             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1415                 1420                 1425             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1430                 1435                 1440             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1445                 1450                 1455             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1460                 1465                 1470             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1475                 1480                 1485             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1490                 1495                 1500             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1505                 1510                 1515             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1520                 1525                 1530             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1535                 1540                 1545             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1550                 1555                 1560             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1565                 1570                 1575             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1580                 1585                 1590             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1595                 1600                 1605             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1610                 1615                 1620             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1625                 1630                 1635             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1640                 1645                 1650             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1655                 1660                 1665             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1670                 1675                 1680             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1685                 1690                 1695             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1700                 1705                 1710             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1715                 1720                 1725             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1730                 1735                 1740             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1745                 1750                 1755             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1760                 1765                 1770             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1775                 1780                 1785             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1790                 1795                 1800             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1805                 1810                 1815             


Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1820                 1825                 1830             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1835                 1840                 1845             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1850                 1855                 1860             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1865                 1870                 1875             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1880                 1885                 1890             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1895                 1900                 1905             


Leu Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser 
    1910                 1915                 1920             


Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu 
    1925                 1930                 1935             


Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn 
    1940                 1945                 1950             


Lys Pro  Glu Ser Asp Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser 
    1955                 1960                 1965             


Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr 
    1970                 1975                 1980             


Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys 
    1985                 1990                 1995             


Ile Lys  Met Leu Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys 
    2000                 2005                 2010         


<210>  109
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109
gactcccaca cattaataat gggcctgaat gactactggg tacata                      46


<210>  110
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  110
gactcccaca cattaattga ctactgggta cata                                   34


<210>  111
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111
gactcccaca ttaatgacta ctgggtacat a                                      31


<210>  112
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112
gactcccaca ataattgact actgggtaca ta                                     32


<210>  113
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  113
gactcccaca ataatgacta ctgggtacat a                                      31


<210>  114
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  114
gactcccaca ttaatttact actgggtaca ta                                     32


<210>  115
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  115
ccacaccaca cctattccaa aatattctac cagaggtaca aggagg                      46


<210>  116
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  116
ccacaccaca ccaaggagg                                                    19


<210>  117
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  117
ccacaccaca caaggagg                                                     18


<210>  118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  118
ccacaccaca ccaaaggagg                                                   20


<210>  119
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  119
ccacaccaca caggagg                                                      17


<210>  120
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  120
ccacaccaca ccaggagg                                                     18


<210>  121
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  121
ccacagccaa tatcatactg aatcctagga atccaactta caagggatgt                  50


<210>  122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  122
ccacccacag caagggatgt                                                   20


<210>  123
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  123
ccacccacaa gggatgt                                                      17


<210>  124
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  124
ccacccacag ggatgt                                                       16


<210>  125
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  125
ccacccacag gt                                                           12


<210>  126
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  126
ccacccacag t                                                            11


<210>  127
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  127
ccacaccaca cctattccaa aatcctgaat gactactggg tacata                      46


<210>  128
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128
ggtgtggtgt ggataaggtt ttaggactta ctgatgaccc atgtat                      46


<210>  129
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  129
aacgagacag aaagtcaaca agg                                               23


<210>  130
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  130
attctaccag aggtacaagg agg                                               23


<210>  131
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  131
aacggggcag aaagtcaaca agg                                               23


<210>  132
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  132
attctgccgg aggtacaagg agg                                               23


<210>  133
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  133
aacgagatag aaagtcaaca agg                                               23


<210>  134
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  134
attttattag aggtacaagg agg                                               23


<210>  135
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  135
ccgctcaact acatggaaac tga                                               23


<210>  136
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  136
cctgggatgc aaggctggtt caa                                               23


<210>  137
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  137
ccgctcaact acatggaaac cga                                               23


<210>  138
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  138
cctgggatgc aaggccggcc caa                                               23


<210>  139
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  139
ccgctcaact acataaaaac tga                                               23


<210>  140
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  140
cctgggatgc aaggctaatt caa                                               23


<210>  141
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  141
cctgaatgac tactgggtac ata                                               23


<210>  142
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  142
gggtattcaa ttaggaaaag agg                                               23


<210>  143
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143
cctgaatgac tactgggcac ata                                               23


<210>  144
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144
gggtgttcaa ttaggaaaag agg                                               23


<210>  145
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145
cctgaatgac tactaaatac ata                                               23


<210>  146
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146
gggtatttaa ttaggaaaag agg                                               23


<210>  147
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147
attctaccag aggtacaagg agg                                               23


<210>  148
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  148
attttattag aggtacaagg agg                                               23


