                         SEQUENCE LISTING

<110>  MPEG LA, LLC
 
<120>  MULTIMERIC OLIGONUCLEOTIDES WITH ENHANCED BIOACTIVITY

<130>  MPEG.007WO

<140>  PCT/US2020/020845
<141>  2020-03-03

<150>  US 62/813599
<151>  2019-03-04

<160>  164    

<170>  Patentin version 3.5

<210>  1
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18791

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 5'-end to 
       a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine linked at the 3'end to an 
       aminohexyl linker

<400>  1
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  2
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18792

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine linked on the 3'end to 
       an aminohexyl linker linked to a trivalent 
       galnac cluster

<400>  2
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  3
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18793

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked 
       on the 5'-end to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine linked on the 3'end to 
       an aminohexyl linker linked to a trivalent 
       galnac cluster

<400>  3
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  4
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18794

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide 
       linked on the 5'-end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<400>  4
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  5
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19569

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked 
       on the 5'-end to a thiohexyl linker


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<400>  5
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  6
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19574

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked 
       on the 5'-end to a thiohexyl linker linked 
       to dithiobismaleimidoethane

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<400>  6
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  7
<211>  22
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18796

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2?-fluoro-2?-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  linked by dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  deoxythymidine

<400>  7
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210>  8
<211>  22
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18797

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2?-fluoro-2?-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide linked to 
       an aminohexyl linker

<400>  8
nnnnnnnnnn nnnnnnnnnn nn                                                22

<210>  9
<211>  22
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18798

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2?-fluoro-2?-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide linked to an 
       aminohexyl linker linked to dithiobismaleimidoethane

<400>  9
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210>  10
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19577

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  cytidine 2'-o-methylribonucleotide linked on the 
       5? end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<400>  10
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  11
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19578

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  cytidine 2'-o-methylribonucleotide linked on the 
       5? end to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<400>  11
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  12
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19579

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  cytidine 2'-o-methylribonucleotide linked on the 
       5? end to a thiohexyl linker linked to 
       dithiobismaleimidoethane

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<400>  12
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  13
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x01162

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxythymidine

<400>  13
ggannannnn aagnnnnann n                                                 21


<210>  14
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x00549

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxythymidine

<400>  14
gnaagannng agangannnn n                                                 21


<210>  15

<400>  15
000


<210>  16
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x00116

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxythymidine

<400>  16
gnaaaggngn gnnaannnan n                                                 21


<210>  17
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x00117

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxythymidine

<400>  17
ugaguuggna cgccuuugcn n                                                 21


<210>  18

<400>  18
000


<210>  19
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x02943

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  adenosine with a 3' phosphorothioate linkage

<400>  19
ggaaucnnan annngaucnn a                                                 21


<210>  20
<211>  23
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x02944

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  cytidine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  cytidine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage


<400>  20
nnggaunaaa nanaaganuc nnu                                               23


<210>  21

<400>  21
000


<210>  22
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x00539

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxythymidine

<400>  22
nnnangnnga gnannnngan n                                                 21


<210>  23
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x00540

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxythymidine

<400>  23
ucgaagnacu nagcgnaagn n                                                 21


<210>  24

<400>  24
000


<210>  25
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18790

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to an aminohexyl linker linked to a trivalent 
       galnac cluster

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<400>  25
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  26
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18795

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide

<400>  26
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  27

<400>  27
000


<210>  28
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20124

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  cytidine 2'-o-methylribonucleotide linked on the 
       5'-end to an aminohexyl linker linked to a trivalent 
       galnac cluster

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<400>  28
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  29
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19583

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide

<400>  29
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  30

<400>  30
000


<210>  31
<211>  22
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20216

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage and linked on the 5'-end to 
       an aminohexyl linker with a 3' phosphorothioate 
       linkage linked to a trivalent galnac cluster

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  inverted deoxythymidine

<400>  31
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210>  32
<211>  23
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19584

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  uridine 2'-o-methylribonucleotide 

<400>  32
nnnnnnnnnn nnnnnnnnnn nnn                                               23


<210>  33

<400>  33
000


<210>  34
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19571

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine linked on the 3'end to an 
       aminohexyl linker linked to a trivalent galnac cluster

<400>  34
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  35
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18788

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine 

<400>  35
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  36

<400>  36 
000


<210>  37
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x15049

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  adenosine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  linked by a thiohexyl linker linked to 
       dithiobismaleimidoethane

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide
<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  deoxythymidine linked on the 3'end to a thiohexyl 
       linker

<400>  37
ggaaucnnan annngaucnn aggannannn naagnnnnan nn                          42


<210>  38
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x12714

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxythymidine 

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  linked by a thiohexyl linker linked to 
       dithiobismaleimidoethane

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  deoxythymidine linked on the 3'end to a 
       thiohexyl linker

<400>  38
ggannannnn aagnnnnann ngnaagannn gagangannn nn                          42


<210>  39
<211>  40
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19575

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'end to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by a aminohexyl linker linked to a trivalent 
       galnac cluster linked to dithiobismaleimidoethane 
       linked to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  inverted deoxythymidine

<400>  39
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn                             40


<210>  40
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19819

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (187)..(18)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  linked by a aminohexyl linker linked to 
       dithiobismaleimidoethane

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  uridine 2'-o-methylribonucleotide linked on the 
       3?end to an aminohexyl linker

<400>  40
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn                          42


<210>  41
<211>  40
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20336

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine 

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by aminohexyl linker, trivalent galnac cluster, 
       dithiobismaleimidoethane, and thiohexyl linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  cytidine 2'-o-methylribonucleotide linked on the 
       5? end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  inverted deoxythymidine

<400>  41
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn                             40


<210>  42

<400>  42 
000


<210>  43

<400>  43 
000


<210>  44
<211>  44
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20366

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  linked by dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  uridine 2'-o-methylribonucleotide

<400>  44
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnn                        44


<210>  45
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x22413

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage 

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  linked by dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine

<400>  45
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn                          42


<210>  46
<211>  62
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20256

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine 

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by aminohexyl linker, trivalent galnac cluster, 
       succinimidyl 3-(2-pyridyldithio)propionate, and 
       an aminohexyl linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  linked by  dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage 

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  inverted deoxythymidine

<400>  46
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60 
 
nn                                                                      62


<210>  47
<211>  44
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20366

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  linked by  dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  uridine 2'-o-methylribonucleotide

<400>  47
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnn                        44


<210>  48
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x22413

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage 

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  linked by dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine

<400>  48
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn                          42


<210>  49

<400>  49 
000


<210>  50

<400>  50
000


<210>  51

<400>  51 
000


<210>  52
<211>  62
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20256

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine 

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by aminohexyl linker, trivalent galnac cluster, 
       succinimidyl 3-(2-pyridyldithio)propionate, 
       and an aminohexyl linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  linked by  dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage 

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  inverted deoxythymidine

<400>  52
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60 

nn                                                                      62


<210>  53

<400>  53 
000


<210>  54

<400>  54 
000


<210>  55

<400>  55 
000


<210>  56

<400>  56 
000


<210>  57

<400>  57 
000


<210>  58

<400>  58 
000


<210>  59

<400>  59 
000


<210>  60

<400>  60 
000


<210>  61

<400>  61 
000


<210>  62

<400>  62 
000


<210>  63

<400>  63 
000


<210>  64

<400>  64 
000


<210>  65

<400>  65 
000


<210>  66

<400>  66 
000


<210>  67

<400>  67 
000


<210>  68

<400>  68 
000


<210>  69

<400>  69 
000


<210>  70

<400>  70 
000


<210>  71

<400>  71 
000


<210>  72

<400>  72 
000


<210>  73

<400>  73 
000


<210>  74

<400>  74 
000


<210>  75

<400>  75
000


<210>  76

<400>  76 
000


<210>  77

<400>  77 
000


<210>  78

<400>  78 
000


<210>  79

<400>  79 
000


<210>  80

<400>  80 
000


<210>  81

<400>  81 
000


<210>  82

<400>  82 
000


<210>  83

<400>  83 
000


<210>  84

<400>  84
000


<210>  85

<400>  85 
000


<210>  86

<400>  86 
000


<210>  87

<400>  87 
000


<210>  88

<400>  88 
000


<210>  89

<400>  89 
000


<210>  90

<400>  90 
000


<210>  91

<400>  91 
000


<210>  92

<400>  92 
000


<210>  93

<400>  93
000


<210>  94

<400>  94 
000


<210>  95

<400>  95 
000


<210>  96

<400>  96 
000


<210>  97

<400>  97 
000


<210>  98

<400>  98 
000


<210>  99

<400>  99 
000


<210>  100

<400>  100 
000


<210>  101

<400>  101
000


<210>  102

<400>  102
000


<210>  103

<400>  103
000


<210>  104

<400>  104
000


<210>  105

<400>  105
000


<210>  106

<400>  106
000


<210>  107

<400>  107
000


<210>  108

<400>  108
000


<210>  109

<400>  109
000


<210>  110

<400>  110
000


<210>  111

<400>  111
000


<210>  112

<400>  112
000


<210>  113

<400>  113
000

10.	.
<210>  114

<400>  114
000


<210>  115

<400>  115
000


<210>  116

<400>  116
000


<210>  117

<400>  117
000


<210>  118

<400>  118 
000


<210>  119

<400>  119
000


<210>  120

<400>  120
000


<210>  121

<400>  121
000


<210>  122

<400>  122
000


<210>  123

<400>  123
000


<210>  124

<400>  124
000


<210>  125
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x15049

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  adenosine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  linked by a thiohexyl linker linked to 
       dithiobismaleimidoethane

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide
<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  deoxythymidine linked on the 3'end to a thiohexyl 
       linker

<400>  125
ggaaucnnan annngaucnn aggannannn naagnnnnan nn                          42


<210>  126
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x12714

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxythymidine 

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  linked by a thiohexyl linker linked to 
       dithiobismaleimidoethane

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  deoxythymidine linked on the 3'end to a thiohexyl 
       linker

<400>  126
ggannannnn aagnnnnann ngnaagannn gagangannn nn                          42


<210>  127
<211>  40
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19575

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'end to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by a aminohexyl linker linked to a trivalent 
       galnac cluster linked to dithiobismaleimidoethane 
       linked to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  inverted deoxythymidine

<400>  127
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn                             40


<210>  128
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19819

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (187)..(18)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  linked by a aminohexyl linker linked to 
       dithiobismaleimidoethane

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  uridine 2'-o-methylribonucleotide linked on the 
       3?end to an aminohexyl linker

<400>  128
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn                          42


<210>  129
<211>  40
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20336

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine 

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by aminohexyl linker, trivalent galnac cluster, 
       dithiobismaleimidoethane, and thiohexyl linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  cytidine 2'-o-methylribonucleotide linked on the 
       5? end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  inverted deoxythymidine

<400>  129
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn                             40


<210>  130
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x15049

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  adenosine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  linked by a thiohexyl linker linked to 
       dithiobismaleimidoethane

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide
<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  deoxythymidine linked on the 3'end to a thiohexyl 
       linker

<400>  130
ggaaucnnan annngaucnn aggannannn naagnnnnan nn                          42


<210>  131
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x12714

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxythymidine 

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  linked by a thiohexyl linker linked to 
       dithiobismaleimidoethane

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  deoxythymidine linked on the 3'end to a thiohexyl 
       linker

<400>  131
ggannannnn aagnnnnann ngnaagannn gagangannn nn                          42


<210>  132
<211>  44
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20366

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  linked by dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  uridine 2'-o-methylribonucleotide

<400>  132
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnn                        44


<210>  133
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x22413

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage 

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  linked by dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine

<400>  133
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn                          42


<210>  134
<211>  62
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20256

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine 

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by aminohexyl linker, trivalent galnac cluster, 
       succinimidyl 3-(2-pyridyldithio)propionate, and 
       an aminohexyl linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  linked by  dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage 

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  inverted deoxythymidine

<400>  134
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60 

nn                                                                      62


<210>  135
<211>  62
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20256

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine 

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by aminohexyl linker, trivalent galnac 
       cluster, succinimidyl 3-(2-pyridyldithio)propionate, 
       and aminohexyl linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  linked by  dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage 

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  inverted deoxythymidine

<400>  135
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60 

nn                                                                      62


<210>  136
<211>  44
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20366

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  linked by  dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  uridine 2'-o-methylribonucleotide

<400>  136
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnn                        44


<210>  137
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x22413

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage 

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  linked by dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-o-methylribonucleotide linked on the 
       5'-end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine

<400>  137
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn                          42


<210>  138
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18790

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on 
       the 5'-end to an aminohexyl linker linked 
       to a trivalent galnac cluster

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<400>  138
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  139
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18795

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2?-fluoro-2?-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide

<400>  139
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  140
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20124

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  cytidine 2'-o-methylribonucleotide to an aminohexyl 
       linker linked to a trivalent galnac cluster

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<400>  140
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  141
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19583

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide

<400>  141
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  142
<211>  22
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20216

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage and linked on the 5'-end to 
       an aminohexyl linker with a 3' phosphorothioate 
       linkage linked to a trivalent galnac cluster

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  inverted deoxythymidine

<400>  142
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210>  143
<211>  23
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x19584

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  uridine 2'-o-methylribonucleotide

<400>  143
nnnnnnnnnn nnnnnnnnnn nnn                                               23


<210>  144
<211>  62
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20256

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 5'-end to 
       a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine 

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by aminohexyl linker, trivalent galnac cluster, 
       succinimidyl 3-(2-pyridyldithio)propionate, and aminohexyl 
       linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  linked by  dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage 

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  adenosine 2'-o-methylribonucleotide with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  inverted deoxythymidine

<400>  144
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nn                                                                      62


<210>  145
<211>  62
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x20256

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on the 5'-end to 
       a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine 

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by aminohexyl linker, trivalent galnac cluster, 
       succinimidyl 3-(2-pyridyldithio)propionate, and aminohexyl 
       linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  linked by  dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage 

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  inverted deoxythymidine

<400>  145
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60 

nn                                                                      62


<210>  146
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x30835

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on 
       the 5'-end to a thiohexyl linker linked to 
       dithiobismaleimidoethane

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine linked on the 3?end to an
       aminohexyl linker

<400>  146
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn                          42


<210>  147
<211>  86
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x30837

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on 
       the 5'-end to a thiohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  inverted deoxythymidine linked on the 3?end to an 
       aminohexyl linker

<400>  147
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60 

nnnnnnnnnn nnnnnnnnnn nnnnnn                                            86


<210>  148
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x18789

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on 
       the 5'-end to an aminohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<400>  148
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  149
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x30833

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on 
       the 5'-end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine linked on the 3?end to 
       an aminohexyl linker

<400>  149
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn                          42


<210>  150
<211>  64
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x34003

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on 
       the 5'-end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  inverted deoxythymidine linked on the 3?end 
       to an aminohexyl linker

<400>  150
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60 

nnnn                                                                    64


<210>  151
<211>  86
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x30836

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on 
       the 5'-end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  inverted deoxythymidine linked on the 3?end to an 
       aminohexyl linker

<400>  151
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60 

nnnnnnnnnn nnnnnnnnnn nnnnnn                                            86


<210>  152
<211>  108
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x34004

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on 
       the 5'-end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  inverted deoxythymidine linked on the 3?end to an 
       aminohexyl linker

<400>  152
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnn                   108


<210>  153
<211>  130
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x34005

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide linked on 
       the 5'-end to a dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  inverted deoxythymidine

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  deoxycytidine

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  deoxyadenosine

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (126)..(126)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (127)..(127)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  inverted deoxythymidine linked on the 3?end to an 
       aminohexyl linker

<400>  153
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60 

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120 

nnnnnnnnnn                                                             130


<210>  154
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x21072

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxythymidine with a 3' phosphorothioate linkage


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxythymidine

<400>  154
nagngnnnnn gnnnnanaan n                                                 21


<210>  155
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x21073

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxythymidine with a 3' phosphorothioate 
       linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxythymidine

<400>  155
unanagagna agaanacugn n                                                 21


<210>  156
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x39850

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage and linked on the 5'-end 
       to an aminohexyl linker linked to a trivalent 
       galnac cluster

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine linked on the 3'end to a 
       thiohexyl linker linked to a 
       dithiobismaleimidoethane

<400>  156
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  157
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x39851

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage and linked on the 
       5'-end to an aminohexyl linker

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine linked on the 3'end to 
       a thiohexyl linker

<400>  157
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  158
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x39855

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2?-fluoro-2?-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  linked by dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  uridine 2'-o-methylribonucleotide

<400>  158
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn                          42


<210>  159
<211>  42
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x39852

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine 

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by  dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  adenosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  inverted deoxythymidine

<400>  159
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn                          42


<210>  160
<211>  44
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x39854

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  uridine 2?-fluoro-2?-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  linked by dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  uridine 2'-o-methylribonucleotide

<400>  160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnn                        44


<210>  161
<211>  40
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic; x39853

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanosine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytidine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytidine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  inverted deoxythymidine 

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  linked by dihexyldisulfide linker

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  cytidine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  uridine 2'-o-methylribonucleotide with a 3' 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  uridine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  guanosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  adenosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  uridine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  cytidine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  guanosine 2'-o-methylribonucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  adenosine 2'-fluoro-2'-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  inverted deoxythymidine

<400>  161
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn                             40


<210>  162
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  162
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  163
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  163
ggtgcatcga tgcaggggg                                                    19

<210>  164
<211>  23
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic 

<400>  164
uuauagagca agaacacugu uuu                                               23
