                         SEQUENCE LISTING

<110>  Qilu Puget Sound Biotherapeutics Corporation
 
<120>  Anti-SIRP alpha Antibodies

<130>  SB-005-WO

<150>  62/813,477
<151>  2019-03-04

<160>  153   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC CDR1 of Ab1_G4, Ab2_G4, Ab4_G4, Ab8_G4,
       Ab9_G4, Ab11_G4, Ab12_G4, and Ab24_G4

<400>  1

Gly Phe Thr Phe Ser Ser Tyr Val Met Ser 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC CDR2 of Ab1_G4

<400>  2

Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Ser Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC CDR3 of Ab1_G4

<400>  3

Ser Leu Thr Gly Ser Ser Phe Asp Tyr 
1               5                   


<210>  4
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of Ab1_G4

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Ser Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Leu Thr Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  5
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VH of Ab1_G4

<400>  5
gaagttcaac tggtggagtc agggggcggc ctcgtgaaac cagggggatc tctgcgcttg       60

agctgcgctg cttcagggtt tactttcagt tcctatgtga tgagttgggt ccgacaaact      120

cctggtaaag ggctcgaatg ggtagcaact atatccagcg ggggaaccta cacctactat      180

ccatcttccg ttaaagggcg attcaccctt tctagggaca atgccaaaaa ttcactgtac      240

ttgcaaatga atagtctgag agctgaggat acagccgttt actactgcgc ttcttcattg      300

actggcagtt catttgatta ttggggacaa ggaaccactg taaccgtgtc tagt            354


<210>  6
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC of Ab1_G4

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Ser Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Leu Thr Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  7
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the HC of Ab1_G4

<400>  7
gaagttcaac tggtggagtc agggggcggc ctcgtgaaac cagggggatc tctgcgcttg       60

agctgcgctg cttcagggtt tactttcagt tcctatgtga tgagttgggt ccgacaaact      120

cctggtaaag ggctcgaatg ggtagcaact atatccagcg ggggaaccta cacctactat      180

ccatcttccg ttaaagggcg attcaccctt tctagggaca atgccaaaaa ttcactgtac      240

ttgcaaatga atagtctgag agctgaggat acagccgttt actactgcgc ttcttcattg      300

actggcagtt catttgatta ttggggacaa ggaaccactg taaccgtgtc tagtgctagc      360

accaaggggc catccgtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcacgaa gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agagagttga gtccaaatat      660

ggccccccat gcccaccatg cccagcacct gagttcctgg ggggaccatc agtcttcctg      720

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga ggggaatgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gagcctctcc     1320

ctgtctctgg gtaaa                                                      1335


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC CDR1 of Ab1_G4 and Ab24_G4

<400>  8

Arg Ala Ser Glu Ser Val Asp Leu Tyr Gly Thr Ser Phe Met His 
1               5                   10                  15  


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of LC CDR2 of Ab1_G4, Ab2_G4, Ab4_G4, Ab8_G4,
       Ab9_G4, Ab11_G4, Ab12_G4, and Ab24_G4

<400>  9

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC CDR3 of Ab1_G4 and Ab24_G4

<400>  10

His Gln Ser Ser Asp Glu Leu Pro Trp Thr 
1               5                   10  


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of Ab1_G4 and Ab24_G4

<400>  11

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Leu Tyr 
            20                  25                  30          


Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ser 
                85                  90                  95      


Asp Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  12
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VL of Ab1_G4 and Ab24_G4

<400>  12
gacattgtct tgacccaatc acctgcaagc ctcgccgtat ctctcgggga gcgggccaca       60

atttcttgcc gggcatcaga aagtgtagac ttgtatggca cttcctttat gcattggtat      120

caacaaaaac ccggccaacc tcctaaactc ttgatttatc gggcctccaa cctcgaatcc      180

ggtgtgcctg atcgtttttc aggttcagga agcagaacag acttcacact caccataaac      240

cccctccagg ctgaagacgt cgccacttac tattgtcacc agtcttcaga cgagctgcct      300

tggacatttg gaggtggaac taaggttgag atcaaa                                336


<210>  13
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC of Ab1_G4 and Ab24_G4

<400>  13

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Leu Tyr 
            20                  25                  30          


Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ser 
                85                  90                  95      


Asp Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  14
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the LC of Ab1_G4 and Ab24_G4

<400>  14
gacattgtct tgacccaatc acctgcaagc ctcgccgtat ctctcgggga gcgggccaca       60

atttcttgcc gggcatcaga aagtgtagac ttgtatggca cttcctttat gcattggtat      120

caacaaaaac ccggccaacc tcctaaactc ttgatttatc gggcctccaa cctcgaatcc      180

ggtgtgcctg atcgtttttc aggttcagga agcagaacag acttcacact caccataaac      240

cccctccagg ctgaagacgt cgccacttac tattgtcacc agtcttcaga cgagctgcct      300

tggacatttg gaggtggaac taaggttgag atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC CDR2 of Ab2_G4, Ab4_G4, Ab11_G4, 
       Ab12_G4, and Ab24_G4

<400>  15

Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC CDR3 of Ab2_G4

<400>  16

Ser Val Asp Gly Ser Ala Phe Asp Tyr 
1               5                   


<210>  17
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of Ab2_G4

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Val Asp Gly Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  18
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VH of Ab2_G4

<400>  18
gaagttcagt tggtagaaag tgggggtggc ctggtcaaac ctggcggatc attgcgtctg       60

tcctgcgccg ccagcggttt tactttttcc agctacgtga tgtcctgggt gagacaaact      120

cctggcaaag gactggagtg ggtggctacc atttcctctg gcggtactta tacttactat      180

ccagattctg ttaaaggtcg gttcacactc tcccgcgata acgctaagaa cagtctttac      240

cttcaaatga acagtctgcg ggccgaggat accgccgtgt attattgtgc ctctagtgtc      300

gacgggagtg catttgacta ctgggggcaa ggaactaccg taaccgtgtc cagt            354


<210>  19
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC of Ab2_G4

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Val Asp Gly Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  20
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the HC of Ab2_G4

<400>  20
gaagttcagt tggtagaaag tgggggtggc ctggtcaaac ctggcggatc attgcgtctg       60

tcctgcgccg ccagcggttt tactttttcc agctacgtga tgtcctgggt gagacaaact      120

cctggcaaag gactggagtg ggtggctacc atttcctctg gcggtactta tacttactat      180

ccagattctg ttaaaggtcg gttcacactc tcccgcgata acgctaagaa cagtctttac      240

cttcaaatga acagtctgcg ggccgaggat accgccgtgt attattgtgc ctctagtgtc      300

gacgggagtg catttgacta ctgggggcaa ggaactaccg taaccgtgtc cagtgctagc      360

accaaggggc catccgtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcacgaa gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agagagttga gtccaaatat      660

ggccccccat gcccaccatg cccagcacct gagttcctgg ggggaccatc agtcttcctg      720

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga ggggaatgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gagcctctcc     1320

ctgtctctgg gtaaa                                                      1335


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC CDR1 of Ab2_G4

<400>  21

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Met Ser Phe Met His 
1               5                   10                  15  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of LC CDR3 of Ab2_G4

<400>  22

His Gln Ser Ser Glu Asn Leu Pro Trp Thr 
1               5                   10  


<210>  23
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of Ab2_G4

<400>  23

Asp Ile Val Ile Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Met Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ser 
                85                  90                  95      


Glu Asn Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  24
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VL of Ab2_G4

<400>  24
gacatagtaa taacccaaag ccccgcaagc ctggctgtgt cacttggtga acgggcaaca       60

atatcctgcc gggcaagcga atctgtagac tcttacggaa tgtcttttat gcactggtac      120

caacagaagc ccggccagcc tcccaaactc ctcatctata gagcctcaaa tttggagagt      180

ggtgtccccg atagattttc tggtagtggt agcaggaccg actttactct tactataaat      240

ccccttcaag cagaagacgt tgccacctac tactgtcacc agagctccga aaatctgcct      300

tggacattcg gggggggtac taaggtcgaa ataaa                                 335


<210>  25
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC of Ab2_G4

<400>  25

Asp Ile Val Ile Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Met Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ser 
                85                  90                  95      


Glu Asn Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  26
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the LC of Ab2_G4

<400>  26
gacatagtaa taacccaaag ccccgcaagc ctggctgtgt cacttggtga acgggcaaca       60

atatcctgcc gggcaagcga atctgtagac tcttacggaa tgtcttttat gcactggtac      120

caacagaagc ccggccagcc tcccaaactc ctcatctata gagcctcaaa tttggagagt      180

ggtgtccccg atagattttc tggtagtggt agcaggaccg actttactct tactataaat      240

ccccttcaag cagaagacgt tgccacctac tactgtcacc agagctccga aaatctgcct      300

tggacattcg gggggggtac taaggtcgaa ataaagcgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC CDR3 of Ab4_G4, Ab8_G4, Ab11_G4, 
       Ab12_G4, and Ab24_G4

<400>  27

Gln Leu Thr Gly Ser Glu Phe Asp Tyr 
1               5                   


<210>  28
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of VH of Ab4_G4, Ab11_G4, Ab12_G4, and 
       Ab24_G4

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Leu Thr Gly Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  29
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VH of Ab4_G4, Ab11_G4, Ab12_G4, and 
       Ab24_G4

<400>  29
gaagttcaac tggtcgaaag cggtggcggg cttgtgaagc ccggagggag tctcagactc       60

tcctgcgcag cttcagggtt cactttcagc agctacgtga tgtcttgggt tagacagaca      120

ccaggtaagg gcctcgaatg ggttgctact atctcctcag ggggaacata tacctactat      180

cctgacagtg tcaagggtcg gtttaccctg tcacgcgaca atgctaagaa ctcactgtac      240

ctccaaatga acagcctgag agctgaggat actgctgtat actactgcgc cagccaactc      300

acagggagtg agttcgatta ctggggccag ggcactaccg taacagtttc aagt            354


<210>  30
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC of Ab4_G4, Ab11_G4, Ab12_G4, and 
       Ab24_G4

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Leu Thr Gly Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  31
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the  HC of Ab4_G4, Ab11_G4, Ab12_G4, and 
       Ab24_G4

<400>  31
gaagttcaac tggtcgaaag cggtggcggg cttgtgaagc ccggagggag tctcagactc       60

tcctgcgcag cttcagggtt cactttcagc agctacgtga tgtcttgggt tagacagaca      120

ccaggtaagg gcctcgaatg ggttgctact atctcctcag ggggaacata tacctactat      180

cctgacagtg tcaagggtcg gtttaccctg tcacgcgaca atgctaagaa ctcactgtac      240

ctccaaatga acagcctgag agctgaggat actgctgtat actactgcgc cagccaactc      300

acagggagtg agttcgatta ctggggccag ggcactaccg taacagtttc aagtgctagc      360

accaaggggc catccgtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcacgaa gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agagagttga gtccaaatat      660

ggccccccat gcccaccatg cccagcacct gagttcctgg ggggaccatc agtcttcctg      720

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga ggggaatgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gagcctctcc     1320

ctgtctctgg gtaaa                                                      1335


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC CDR1 of  Ab4_G4, Ab8_G4, Ab9_G4, 
       Ab11_G4, and  Ab12_G4

<400>  32

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC CDR3 of Ab4_G4, Ab8_G4, and  
       Ab12_G4

<400>  33

His Gln Ser Ala Asp Leu Pro Trp Thr 
1               5                   


<210>  34
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of Ab4_G4

<400>  34

Asp Ile Val Ile Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ala 
                85                  90                  95      


Asp Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  35
<211>  332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VL of Ab4_G4

<400>  35
gacattgtaa taacccaaag tccagcaagc ctcgccgtta gtcttgggga aagggcaact       60

attagctgcc gtgcttctga atctgtggat tcctatggaa atagcttcat gcactggtat      120

caacaaaagc ctgggcaacc tcccaagctc ttgatttata gggcatcaaa ccttgagtct      180

ggcgtcccag atcggttttc aggctccggg agtaggactg actttactct cactatcaat      240

ccactccagg cagaggatgt agcaacttat tattgtcatc aaagtgctga tctcccctgg      300

actttcggtg gggggaccaa agttgagata aa                                    332


<210>  36
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC of Ab4_G4

<400>  36

Asp Ile Val Ile Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ala 
                85                  90                  95      


Asp Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  37
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the LC of Ab4

<400>  37
gacattgtaa taacccaaag tccagcaagc ctcgccgtta gtcttgggga aagggcaact       60

attagctgcc gtgcttctga atctgtggat tcctatggaa atagcttcat gcactggtat      120

caacaaaagc ctgggcaacc tcccaagctc ttgatttata gggcatcaaa ccttgagtct      180

ggcgtcccag atcggttttc aggctccggg agtaggactg actttactct cactatcaat      240

ccactccagg cagaggatgt agcaacttat tattgtcatc aaagtgctga tctcccctgg      300

actttcggtg gggggaccaa agttgagata aagcgtacgg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC CDR2 of Ab8_G4

<400>  38

Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of Ab8_G4

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Leu Thr Gly Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  40
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VH of Ab8_G4

<400>  40
gaagtccaac tggttgagtc aggcggtggt ctcgtcaaac ctggggggtc cttgcgcctg       60

tcatgcgcag cttctggatt cacattttca agttacgtga tgagttgggt cagacagacc      120

ccaggaaaag gcctcgaatg ggtggccaca atttcctccg ggggaaccta tacctattac      180

cccgagtctg tgaagggacg gtttactctt tccagagaca atgctaaaaa cagtctgtac      240

ttgcaaatga actccctccg agctgaggac actgctgtgt attattgcgc ctcacaactg      300

actgggtccg agttcgacta ttggggccaa ggtactaccg taactgtctc tagt            354


<210>  41
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC of Ab8_G4

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Leu Thr Gly Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  42
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the HC of Ab8_G4

<400>  42
gaagtccaac tggttgagtc aggcggtggt ctcgtcaaac ctggggggtc cttgcgcctg       60

tcatgcgcag cttctggatt cacattttca agttacgtga tgagttgggt cagacagacc      120

ccaggaaaag gcctcgaatg ggtggccaca atttcctccg ggggaaccta tacctattac      180

cccgagtctg tgaagggacg gtttactctt tccagagaca atgctaaaaa cagtctgtac      240

ttgcaaatga actccctccg agctgaggac actgctgtgt attattgcgc ctcacaactg      300

actgggtccg agttcgacta ttggggccaa ggtactaccg taactgtctc tagtgctagc      360

accaaggggc catccgtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcacgaa gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agagagttga gtccaaatat      660

ggccccccat gcccaccatg cccagcacct gagttcctgg ggggaccatc agtcttcctg      720

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga ggggaatgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gagcctctcc     1320

ctgtctctgg gtaaa                                                      1335


<210>  43
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of Ab8_G4

<400>  43

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ala 
                85                  90                  95      


Asp Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  44
<211>  332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VL of Ab8_G4

<400>  44
gacatagtta tgactcaaag tcctgcctcc ttggccgtat ctctcgggga gagggcaaca       60

atttcttgtc gagcctcaga gagcgtcgat agctatggca atagtttcat gcattggtac      120

cagcagaagc ccggccaacc ccccaaactc ttgatttata gagcatcaaa tcttgaatct      180

ggggtgccag accgtttctc aggtagcggc tctcggactg acttcaccct tactataaat      240

cctctgcaag ccgaggacgt tgcaacttat tactgtcatc agtcagcaga cctgccctgg      300

actttcgggg gaggcacaaa ggttgaaata aa                                    332


<210>  45
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC of Ab8_G4

<400>  45

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ala 
                85                  90                  95      


Asp Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  46
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the LC of Ab8_G4

<400>  46
gacatagtta tgactcaaag tcctgcctcc ttggccgtat ctctcgggga gagggcaaca       60

atttcttgtc gagcctcaga gagcgtcgat agctatggca atagtttcat gcattggtac      120

cagcagaagc ccggccaacc ccccaaactc ttgatttata gagcatcaaa tcttgaatct      180

ggggtgccag accgtttctc aggtagcggc tctcggactg acttcaccct tactataaat      240

cctctgcaag ccgaggacgt tgcaacttat tactgtcatc agtcagcaga cctgccctgg      300

actttcgggg gaggcacaaa ggttgaaata aagcgtacgg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC CDR2 of Ab9_G4

<400>  47

Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asn Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC CDR3 of Ab9_G4

<400>  48

Ser Met Thr Gly Ser Ser Phe Asp Tyr 
1               5                   


<210>  49
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of Ab9_G4

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Ser Met Thr Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  50
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VH of Ab9_G4

<400>  50
gaagtgcagc tcgtcgaatc agggggtgga ttggttaaac caggcggcag cttgcgactg       60

agttgtgcag cttctggttt cactttctcc agttatgtca tgtcctgggt gcggcagacc      120

ccagggaaag gattggaatg ggtagccaca attagtagcg gaggcaccta cacttactat      180

cccaacagcg ttaaaggtag gtttaccctc tcaagggata atgccaagaa cagcctgtac      240

cttcaaatga atagtcttcg ggccgaggac acagctgttt actattgtgt gtcaagtatg      300

acagggagca gttttgacta ctggggccaa ggtactacag tgacagtttc ctca            354


<210>  51
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the HC of Ab9_G4

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Ser Met Thr Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  52
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the HC of Ab9_G4

<400>  52
gaagtgcagc tcgtcgaatc agggggtgga ttggttaaac caggcggcag cttgcgactg       60

agttgtgcag cttctggttt cactttctcc agttatgtca tgtcctgggt gcggcagacc      120

ccagggaaag gattggaatg ggtagccaca attagtagcg gaggcaccta cacttactat      180

cccaacagcg ttaaaggtag gtttaccctc tcaagggata atgccaagaa cagcctgtac      240

cttcaaatga atagtcttcg ggccgaggac acagctgttt actattgtgt gtcaagtatg      300

acagggagca gttttgacta ctggggccaa ggtactacag tgacagtttc ctcagctagc      360

accaaggggc catccgtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcacgaa gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agagagttga gtccaaatat      660

ggccccccat gcccaccatg cccagcacct gagttcctgg ggggaccatc agtcttcctg      720

ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga ggggaatgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gagcctctcc     1320

ctgtctctgg gtaaa                                                      1335


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC CDR3 of Ab9_G4

<400>  53

His Gln Ser Ser Glu Gln Leu Pro Trp Thr 
1               5                   10  


<210>  54
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of Ab9_G4

<400>  54

Asp Ile Val Ile Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ser 
                85                  90                  95      


Glu Gln Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  55
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VL of Ab9_G4

<400>  55
gacatcgtaa ttacccagag cccagcttcc ctggcagtga gcctgggcga acgagctact       60

ataagttgcc gtgctagtga aagcgttgac tcatacggga actcctttat gcactggtac      120

cagcaaaaac ctggccaacc tccaaaattg cttatttaca gggcttccaa tcttgagagc      180

ggcgtgcccg acaggttctc cggttccggc agtcgaacag actttaccct gactataaat      240

cccctgcaag cagaagacgt agccacatat tactgccacc aatcctctga gcagcttccc      300

tggacatttg ggggtggcac taaggttgag atcaaa                                336


<210>  56
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC of Ab9_G4

<400>  56

Asp Ile Val Ile Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ser 
                85                  90                  95      


Glu Gln Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  57
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the LC of Ab9_G4

<400>  57
gacatcgtaa ttacccagag cccagcttcc ctggcagtga gcctgggcga acgagctact       60

ataagttgcc gtgctagtga aagcgttgac tcatacggga actcctttat gcactggtac      120

cagcaaaaac ctggccaacc tccaaaattg cttatttaca gggcttccaa tcttgagagc      180

ggcgtgcccg acaggttctc cggttccggc agtcgaacag actttaccct gactataaat      240

cccctgcaag cagaagacgt agccacatat tactgccacc aatcctctga gcagcttccc      300

tggacatttg ggggtggcac taaggttgag atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC CDR3 of Ab11_G4

<400>  58

His Gln Ser Gly Asp Leu Pro Trp Thr 
1               5                   


<210>  59
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of Ab11_G4

<400>  59

Asp Ile Val Ile Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Gly 
                85                  90                  95      


Asp Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  60
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VL of Ab11_G4

<400>  60
gacattgtca ttactcagtc ccctgccagt cttgctgtga gcttgggcga acgcgctacc       60

atttcctgcc gcgcatcaga gagcgtagac agctacggga acagctttat gcactggtat      120

caacagaaac ccggtcaacc ccctaaattg ctcatttacc gcgcatcaaa ccttgaatca      180

ggcgttccag accggttttc aggttctggt agccgaacag atttcaccct cacaattaac      240

cctcttcaag ccgaagacgt ggccacctat tattgtcacc agagtggcga ccttccatgg      300

actttcggag gtggcactaa agtggagatt aaa                                   333


<210>  61
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC of Ab11_G4

<400>  61

Asp Ile Val Ile Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Gly 
                85                  90                  95      


Asp Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  62
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the LC of Ab11_G4

<400>  62
gacattgtca ttactcagtc ccctgccagt cttgctgtga gcttgggcga acgcgctacc       60

atttcctgcc gcgcatcaga gagcgtagac agctacggga acagctttat gcactggtat      120

caacagaaac ccggtcaacc ccctaaattg ctcatttacc gcgcatcaaa ccttgaatca      180

ggcgttccag accggttttc aggttctggt agccgaacag atttcaccct cacaattaac      240

cctcttcaag ccgaagacgt ggccacctat tattgtcacc agagtggcga ccttccatgg      300

actttcggag gtggcactaa agtggagatt aaacgtacgg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  63
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of Ab12_G4

<400>  63

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ala 
                85                  90                  95      


Asp Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  64
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the VL of Ab12_G4

<400>  64
gatatagtac tcactcaatc tccagcaagc ctggcagtct cactgggtga acgagctact       60

atttcctgcc gagcctctga atctgtagat tcttacggaa acagctttat gcactggtat      120

caacagaagc caggtcagcc ccctaagctg ctgatatacc gtgcaagtaa tctggagagt      180

ggtgtacccg atagatttag cggcagcgga tcaaggacag atttcaccct gacaataaat      240

ccactgcaag ctgaagacgt ggctacatat tactgtcacc aatcagcaga cctcccttgg      300

actttcggtg gcggcacaaa ggttgaaatt aaa                                   333


<210>  65
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the LC of Ab12_G4

<400>  65

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Ala 
                85                  90                  95      


Asp Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  66
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the LC of Ab12_G4

<400>  66
gatatagtac tcactcaatc tccagcaagc ctggcagtct cactgggtga acgagctact       60

atttcctgcc gagcctctga atctgtagat tcttacggaa acagctttat gcactggtat      120

caacagaagc caggtcagcc ccctaagctg ctgatatacc gtgcaagtaa tctggagagt      180

ggtgtacccg atagatttag cggcagcgga tcaaggacag atttcaccct gacaataaat      240

ccactgcaag ctgaagacgt ggctacatat tactgtcacc aatcagcaga cctcccttgg      300

actttcggtg gcggcacaaa ggttgaaatt aaacgtacgg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  67
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence for the VHs of Ab1_G4, Ab2_G4, 
       Ab4_G4, Ab8_G4, Ab9_G4, Ab11_G4, Ab12_G4, and Ab24_G4


<220>
<221>  Xaa
<222>  (62)..(62)
<223>  Xaa is serine, aspartate, glutamate, or asparagine

<220>
<221>  Xaa
<222>  (97)..(97)
<223>  Xaa is alanine or valine

<220>
<221>  Xaa
<222>  (99)..(99)
<223>  Xaa is serine or glutamine

<220>
<221>  Xaa
<222>  (100)..(100)
<223>  Xaa is leucine, valine, or methionine

<220>
<221>  Xaa
<222>  (101)..(101)
<223>  Xaa is threonine or aspartate

<220>
<221>  Xaa
<222>  (104)..(104)
<223>  Xaa is serine, glutamate, or alanine

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Xaa Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Xaa Ser Xaa Xaa Xaa Gly Ser Xaa Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  68
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence for the VLs of Ab1_G4, Ab2_G4, 
       Ab4_G4, Ab8_G4, Ab9_G4, Ab11_G4, Ab12_G4, and Ab24_G4


<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is isoleucine, leucine, or methionine

<220>
<221>  Xaa
<222>  (31)..(31)
<223>  Xaa is serine or leucine

<220>
<221>  Xaa
<222>  (34)..(34)
<223>  Xaa is asparagine, methionine, or threonine

<220>
<221>  Xaa
<222>  (96)..(96)
<223>  Xaa is serine, alanine, or glycine

<220>
<221>  Xaa
<222>  (97)..(97)
<223>  Xaa is aspartate, glutamate, or no amino acid

<220>
<221>  Xaa
<222>  (98)..(98)
<223>  Xaa is aspartate, glutamate, asparagine, or glutamine

<400>  68

Asp Ile Val Xaa Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Xaa Tyr 
            20                  25                  30          


Gly Xaa Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Xaa 
                85                  90                  95      


Xaa Xaa Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  69
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence for the VH CDR2 of Ab1_G4, 
       Ab2_G4, Ab4_G4, Ab8_G4, Ab9_G4, Ab11_G4, Ab12_G4, and Ab24_G4


<220>
<221>  Xaa
<222>  (13)..(13)
<223>  Xaa is aspartate, serine, asparagine, or glutamate

<400>  69

Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Xaa Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence for the VH CDR3 of Ab1_G4, 
       Ab2_G4, Ab4_G4, Ab8_G4, Ab9_G4, Ab11_G4, Ab12_G4, and Ab24_G4


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is serine or glutamine

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is leucine, valine, or methionine

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is threonine or aspartate

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is serine, alanine, or glutamate

<400>  70

Xaa Xaa Xaa Gly Ser Xaa Phe Asp Tyr 
1               5                   


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence for the VL CDR1 of Ab1_G4, 
       Ab2_G4, Ab4_G4, Ab8_G4, Ab9_G4, Ab11_G4, Ab12_G4, and Ab24_G4


<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is serine or leucine

<220>
<221>  Xaa
<222>  (11)..(11)
<223>  Xaa is methionine, asparagine, or threonine

<400>  71

Arg Ala Ser Glu Ser Val Asp Xaa Tyr Gly Xaa Ser Phe Met His 
1               5                   10                  15  


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence for the VL CDR3 of Ab1_G4, 
       Ab2_G4, Ab4_G4, Ab8_G4, Ab9_G4, Ab11_G4, Ab12_G4, and Ab24_G4


<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is serine, alanine, or glycine

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is glutamate, aspartate, or no amino acid

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is glutamate, aspartate, asparagine, or glutamine

<400>  72

His Gln Ser Xaa Xaa Xaa Leu Pro Trp Thr 
1               5                   10  


<210>  73
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of human heavy chain variable 
       domains (VHs)


<220>
<221>  Xaa
<222>  (1)..(16)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (17)..(17)
<223>  Xaa is serine or threonine

<220>
<221>  Xaa
<222>  (18)..(18)
<223>  Xaa is valine or leucine

<220>
<221>  Xaa
<222>  (19)..(19)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (20)..(20)
<223>  Xaa is valine or leucine

<220>
<221>  Xaa
<222>  (21)..(21)
<223>  Xaa is serine or threonine

<220>
<221>  Xaa
<222>  (22)..(35)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (36)..(37)
<223>  Xaa is any amino acid or no amino acid

<220>
<221>  Xaa
<222>  (39)..(43)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (45)..(45)
<223>  Xaa is lysine or glutamine

<220>
<221>  Xaa
<222>  (48)..(54)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (55)..(57)
<223>  Xaa is any amino acid or no amino acid

<220>
<221>  Xaa
<222>  (58)..(87)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (88)..(90)
<223>  Xaa is any amino acid or no amino acid

<220>
<221>  Xaa
<222>  (91)..(108)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (109)..(119)
<223>  Xaa is any amino acid or no amino acid

<220>
<221>  Xaa
<222>  (120)..(132)
<223>  Xaa is any amino acid

<400>  73

Xaa Xaa Xaa Leu Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Trp Xaa Arg Gln Xaa Xaa Gly Xaa Gly Leu Xaa 
        35                  40                  45              


Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa Xaa 
                85                  90                  95      


Xaa Tyr Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Xaa Gln Gly Xaa Xaa Val 
        115                 120                 125             


Xaa Val Ser Xaa 
    130         


<210>  74
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of first heavy chain constant 
       domains (CH1s)


<220>
<221>  Xaa
<222>  (1)..(98)
<223>  Xaa is any amino acid

<400>  74

Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Leu Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa 
        


<210>  75
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210>  76
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val 
        


<210>  77
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  77

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  78
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  78

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  79
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  79

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  80
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  80

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  81
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  81

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro 
    50                  55                  60                  


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
65                  70                  75                  80  


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                85                  90                  95      


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp 
            100                 105                 110         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        115                 120                 125             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    130                 135                 140                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
145                 150                 155                 160 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                165                 170                 175     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            180                 185                 190         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        195                 200                 205             


Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn 
    210                 215                 220                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
225                 230                 235                 240 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser 
                245                 250                 255     


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
            260                 265                 270         


Leu Ser Leu Ser Pro Gly Lys 
        275                 


<210>  82
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  82

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  83
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of human light chain variable 
       domains (VLs)


<220>
<221>  Xaa
<222>  (1)..(27)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (28)..(33)
<223>  Xaa is any amino acid or no amino acid

<220>
<221>  Xaa
<222>  (34)..(63)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (64)..(64)
<223>  Xaa is isoleucine or valine

<220>
<221>  Xaa
<222>  (65)..(89)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (90)..(90)
<223>  Xaa is alanine or glycine

<220>
<221>  Xaa
<222>  (91)..(91)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (93)..(93)
<223>  Xaa is tyrosine or phenylalanine

<220>
<221>  Xaa
<222>  (94)..(101)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (102)..(102)
<223>  Xaa is any amino acid or no amino acid

<220>
<221>  Xaa
<222>  (103)..(104)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (107)..(107)
<223>  Xaa is glutamine or glycine

<220>
<221>  Xaa
<222>  (110)..(113)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (114)..(114)
<223>  Xaa is any amino acid or no amino acid

<220>
<221>  Xaa
<222>  (115)..(117)
<223>  Xaa is any amino acid

<400>  83

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Pro Xaa Arg Phe Ser Gly Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Gly Xaa Gly Thr Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa 
        115         


<210>  84
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of kappa light chain constant
       domains (CLs)


<220>
<221>  Xaa
<222>  (1)..(107)
<223>  Xaa is any amino acid

<400>  84

Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa Ile Xaa Pro Pro Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Xaa Val Cys Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Pro Xaa Xaa Xaa Xaa Val Xaa Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Gln Xaa Ser Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Ser Xaa Ser Ser Thr Leu Thr Leu Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Cys 
            100                 105         


<210>  85
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus amino acid sequence of lambda CLs


<220>
<221>  Xaa
<222>  (1)..(66)
<223>  Xaa is any amino acid

<220>
<221>  Xaa
<222>  (67)..(67)
<223>  Xaa is alanine or methionine

<220>
<221>  Xaa
<222>  (68)..(107)
<223>  Xaa is any amino acid

<400>  85

Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa Leu Xaa Pro Pro Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Val Cys Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Pro Xaa Xaa Xaa Xaa Val Xaa Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Glu Xaa Thr Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Asx Xaa Ser Ser Tyr Leu Ser Leu Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Cys 
            100                 105         


<210>  86
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-Programmed Cell Death 1 
       (anti-PD1) antibody Ab1

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Tyr Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Phe Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  87
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab1

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Val Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  88
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab2

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Tyr Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Asn Thr Tyr Gly Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  89
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab2

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Val Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  90
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab3

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Ser Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Tyr Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ile Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Phe Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  91
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab3

<400>  91

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Val Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  92
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab4

<400>  92

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Phe Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Tyr Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  93
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab4

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  94
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab5

<400>  94

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Phe Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Phe Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  95
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab5

<400>  95

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Leu Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  96
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab6

<400>  96

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Tyr Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Gly Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Tyr Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  97
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab6

<400>  97

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  98
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab7

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Tyr Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ile Asp Lys Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Leu Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  99
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab7

<400>  99

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Phe Ile Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asn His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  100
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab8

<400>  100

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Tyr Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ile Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Asn Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  101
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab8

<400>  101

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Ile Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asn His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  102
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab9

<400>  102

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Tyr Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ile Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Phe Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  103
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab9

<400>  103

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Leu Ile Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asn His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  104
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab10

<400>  104

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Phe Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ile Asp Lys Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Gly Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Tyr Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  105
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab10

<400>  105

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Phe Ile Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asn His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  106
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab11

<400>  106

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Gly Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Tyr Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  107
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab11

<400>  107

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe Ile Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asn His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  108
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab12

<400>  108

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Phe Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ile Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Phe Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  109
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab12

<400>  109

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Ile Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asn His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  110
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab13

<400>  110

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Tyr Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Leu Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  111
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab13

<400>  111

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ala Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  112
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab14

<400>  112

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Tyr Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Gly Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Tyr Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  113
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab14

<400>  113

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Leu Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  114
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-PD1 antibody Ab15

<400>  114

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asp Pro Tyr Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Leu Thr Tyr Gly Gly Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  115
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-PD1 antibody Ab15

<400>  115

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  116
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 1E1

<400>  116

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asn Pro Ser Glu Lys Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  117
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-CTLA4 antibody 1E1

<400>  117

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Met Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  118
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 2F1

<400>  118

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr His Arg Ser Glu Lys Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  119
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-CTLA4 antibodies 2F1 and 
       3G1

<400>  119

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Met Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  120
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 3G1

<400>  120

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Lys Ser Ser Glu Lys Tyr Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  121
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 4H1

<400>  121

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asn Pro Ser Lys Lys Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Phe Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-CTLA4 antibodies 4H1 and 
       7A4

<400>  122

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Met Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  123
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 5B2

<400>  123

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Lys Ser Ser Glu Lys Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-CTLA4 antibody 5B2

<400>  124

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Met Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  125
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 6E3

<400>  125

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Lys Thr Ser Glu Lys Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  126
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-CTLA4 antibody 6E3

<400>  126

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Met Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  127
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 7A4

<400>  127

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Gln Thr Ser Glu Lys Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  128
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 8B4

<400>  128

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Gln Pro Ser Glu Lys Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Phe Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  129
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-CTLA4 antibody 8B4

<400>  129

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Met Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  130
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 9C4

<400>  130

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Lys Ser Ser Glu Lys Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  131
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-CTLA4 antibody 9C4

<400>  131

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Asn Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  132
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 10D4

<400>  132

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr His Pro Ser Lys Lys Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  133
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-CTLA4 antibody 10D4

<400>  133

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  134
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 11F4

<400>  134

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Lys Pro Ser Glu Lys Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  135
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-CTLA4 antibody 11F4

<400>  135

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  136
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VH of anti-CTLA4 antibody 12G4

<400>  136

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asn Thr Ser Lys Lys Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  137
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the VL of anti-CTLA4 antibody 12G4

<400>  137

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  138
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  138

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys 
        115         


<210>  139
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  139

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys 
        115     


<210>  140
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  140

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu 
            340                 345                 350         


Leu Val Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln 
        355                 360                 365             


Lys Lys Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu 
    370                 375                 380                 


Lys Asn Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala 
385                 390                 395                 400 


Asp Leu Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu 
                405                 410                 415     


Pro Asn Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro 
            420                 425                 430         


Ala Ser Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu 
        435                 440                 445             


Asn Arg Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser 
    450                 455                 460                 


Glu Tyr Ala Ser Val Gln Val Pro Arg Lys 
465                 470                 


<210>  141
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Pro Val Pro Ala Ser Trp Pro His Pro Pro Gly Pro Phe Leu Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Gly Leu Thr Glu Val Ala Gly Glu Glu Glu Leu 
            20                  25                  30          


Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys Thr 
        35                  40                  45              


Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro Val 
    50                  55                  60                  


Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys 
                85                  90                  95      


Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro Ala 
            100                 105                 110         


Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Glu 
        115                 120                 125             


Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly Ala 
    130                 135                 140                 


Lys Pro Ser Ala Pro Val Val Leu Gly Pro Ala Ala Arg Thr Thr Pro 
145                 150                 155                 160 


Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg 
                165                 170                 175     


Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe 
            180                 185                 190         


Gln Thr Asn Val Asp Pro Thr Gly Gln Ser Val Ala Tyr Ser Ile Arg 
        195                 200                 205             


Ser Thr Ala Arg Val Val Leu Asp Pro Trp Asp Val Arg Ser Gln Val 
    210                 215                 220                 


Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly 
225                 230                 235                 240 


Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu Val 
                245                 250                 255     


Thr Gln Gln Pro Met Arg Val Gly Asn Gln Val Asn Val Thr Cys Gln 
            260                 265                 270         


Val Arg Lys Phe Tyr Pro Gln Ser Leu Gln Leu Thr Trp Ser Glu Asn 
        275                 280                 285             


Gly Asn Val Cys Gln Arg Glu Thr Ala Ser Thr Leu Thr Glu Asn Lys 
    290                 295                 300                 


Asp Gly Thr Tyr Asn Trp Thr Ser Trp Phe Leu Val Asn Ile Ser Asp 
305                 310                 315                 320 


Gln Arg Asp Asp Val Val Leu Thr Cys Gln Val Lys His Asp Gly Gln 
                325                 330                 335     


Leu Ala Val Ser Lys Arg Leu Ala Leu Glu Val Thr Val His Gln Lys 
            340                 345                 350         


Asp Gln Ser Ser Asp Ala Thr Pro Gly Pro Ala Ser Ser Leu Thr Ala 
        355                 360                 365             


Leu Leu Leu Ile Ala Val Leu Leu Gly Pro Ile Tyr Val Pro Trp Lys 
    370                 375                 380                 


Gln Lys Thr 
385         


<210>  142
<211>  161
<212>  PRT
<213>  Macaca fascicularis

<400>  142

Glu Glu Glu Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Asp Ser Ala Thr Leu Asn Cys Thr Val Ser Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Leu Lys Glu Gly His Phe Pro Arg Val Thr Pro Val Ser 
    50                  55                  60                  


Asp Pro Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Val Glu Leu Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Ser Arg Gly Gly Gly Gly Ser Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu Gly Gly Ser His His His His His His 
    130                 135                 140                 


Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
145                 150                 155                 160 


Glu 
    


<210>  143
<211>  165
<212>  PRT
<213>  Macaca fascicularis

<400>  143

Glu Glu Glu Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Thr Leu Asn Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr His Gln Lys Glu Gly His Phe Pro Arg Val Thr Pro Val Ser 
    50                  55                  60                  


Asp Pro Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Val Glu Leu Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Ser Arg Gly Gly Gly Gly Ser Gly Lys Pro 
        115                 120                 125             


Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Gly Ser His His 
    130                 135                 140                 


His His His His Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys 
145                 150                 155                 160 


Ile Glu Trp His Glu 
                165 


<210>  144
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 
1               5                   10                  15      


Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Asp Glu 
            20                  25                  30          


Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly Glu 
        35                  40                  45              


Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly Pro 
    50                  55                  60                  


Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu Thr 
                85                  90                  95      


Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro 
            100                 105                 110         


Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 
        115                 120                 125             


Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
    130                 135                 140                 


Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Val Arg Ala Thr 
145                 150                 155                 160 


Pro Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 
                165                 170                 175     


Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 
            180                 185                 190         


Phe Gln Thr Asn Val Asp Pro Ala Gly Asp Ser Val Ser Tyr Ser Ile 
        195                 200                 205             


His Ser Thr Ala Arg Val Val Leu Thr Arg Gly Asp Val His Ser Gln 
    210                 215                 220                 


Val Ile Cys Glu Ile Ala His Ile Thr Leu Gln Gly Asp Pro Leu Arg 
225                 230                 235                 240 


Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu 
                245                 250                 255     


Val Thr Gln Gln Pro Met Arg Ala Glu Asn Gln Ala Asn Val Thr Cys 
            260                 265                 270         


Gln Val Ser Asn Phe Tyr Pro Arg Gly Leu Gln Leu Thr Trp Leu Glu 
        275                 280                 285             


Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu Ile Glu Asn 
    290                 295                 300                 


Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Thr Cys 
305                 310                 315                 320 


Ala His Arg Asp Asp Val Val Leu Thr Cys Gln Val Glu His Asp Gly 
                325                 330                 335     


Gln Gln Ala Val Ser Lys Ser Tyr Ala Leu Glu Ile Ser Ala His Gln 
            340                 345                 350         


Lys Glu His Gly Ser Asp Ile Thr His Glu Ala Ala Leu Ala Pro Thr 
        355                 360                 365             


Ala Pro Leu Leu Val Ala Leu Leu Leu Gly Pro Lys Leu Leu Leu Val 
    370                 375                 380                 


Val Gly Val Ser Ala Ile Tyr Ile Cys Trp Lys Gln Lys Ala 
385                 390                 395             


<210>  145
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature amino acid sequence of CD47:Fc including the amino 
       terminal Ig-like domain of human CD47 and a human IgG1 Fc 
       fragment

<400>  145

Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn Asp 
1               5                   10                  15      


Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn Thr 
            20                  25                  30          


Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr Thr 
        35                  40                  45              


Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser Ser 
    50                  55                  60                  


Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu Lys 
65                  70                  75                  80  


Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys Glu 
                85                  90                  95      


Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys Tyr 
            100                 105                 110         


Arg Val Val Ser Trp Ala Ala Ala Glu Pro Lys Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 


<210>  146
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the Ab24_G2 HC

<400>  146
gaagttcaac tggtcgaaag cggtggcggg cttgtgaagc ccggagggag tctcagactc       60

tcctgcgcag cttcagggtt cactttcagc agctacgtga tgtcttgggt tagacagaca      120

ccaggtaagg gcctcgaatg ggttgctact atctcctcag ggggaacata tacctactat      180

cctgacagtg tcaagggtcg gtttaccctg tcacgcgaca atgctaagaa ctcactgtac      240

ctccaaatga acagcctgag agctgaggat actgctgtat actactgcgc cagccaactc      300

acagggagtg agttcgatta ctggggccag ggcactaccg taacagtttc aagtgctagc      360

accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgctc tgaccagcgg cgtgcacacc ttcccagctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcaact tcggcaccca gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agacagttga gcgcaaatgt      660

tgtgtcgagt gcccaccgtg cccagcacca cctgtggcag gaccgtcagt cttcctcttc      720

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      780

gtggacgtga gccacgaaga ccccgaggtc cagttcaact ggtacgtgga cggcgtggag      840

gtgcataatg ccaagacaaa gccacgggag gagcagttca acagcacgtt ccgtgtggtc      900

agcgtcctca ccgttgtgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc      960

tccaacaaag gcctcccagc ccccatcgag aaaaccatct ccaaaaccaa agggcagccc     1020

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1080

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc     1140

aatgggcagc cggagaacaa ctacaagacc acacctccca tgctggactc cgacggctcc     1200

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1260

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1320

tctccgggta aa                                                         1332


<210>  147
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature amino acid sequence of the Ab24_G2 HC

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Leu Thr Gly Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  148
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the Ab24_4422PA HC

<400>  148
gaggtgcagc tggtggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttccggctt caccttctcc agctacgtga tgtcctgggt ccgacagacc      120

cctggcaaag gactggaatg ggtcgccaca atctcctccg gcggcaccta cacctactat      180

cccgactctg tgaagggcag attcaccctg tccagagaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc ttctcagctg      300

accggctccg agttcgatta ttggggccag ggcaccaccg tgaccgtgtc ctctgcttct      360

accaagggac ccagcgtgtt ccctctggct ccttgctcca gatccacctc cgagtctaca      420

gctgctctgg gctgcctggt caaggactac tttcctgagc ctgtgacagt gtcctggaac      480

tctggcgctc tgacatccgg cgtgcacaca tttccagctg tgctgcagtc ctccggcctg      540

tactctctgt cctctgtcgt gacagtgccc tcctctagcc tgggcaccaa gacctatacc      600

tgcaatgtgg accacaagcc ttccaacacc aaggtggaca agcgcgtgga atctaagtac      660

ggccctcctt gtcctccatg tcctgctcct ccagtggctg gcccttccgt gtttctgttc      720

cctccaaagc ctaaggacac cctgatgatc tctcggaccc ctgaagtgac ctgcgtggtg      780

gtggatgtgt ctcacgagga tcctgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaatg ccaagaccaa gcctagagag gaacagttca actccacctt cagagtggtg      900

tccgtgctga ccgtggtgca tcaggattgg ctgaacggca aagagtacaa gtgcaaggtg      960

tccaacaaag gcctggccgc tcctatcgaa aagaccatct ctaagaccaa ggggcagccc     1020

cgggaacctc aggtttacac actgcctcca agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gcctcgtgaa gggcttctac ccttccgata tcgccgtgga atgggagtcc     1140

aatggccagc cagagaacaa ctacaagacc acacctccta tgctggactc cgacggctca     1200

ttcttcctgt actccaagct gacagtggac aagtccagat ggcagcaggg caacgtgttc     1260

tcctgcagcg tgatgcacga ggccctgcac aatcactaca cccagaagtc cctgtctctg     1320

agccctggca ag                                                         1332


<210>  149
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature amino acid sequence of the Ab24_4422PA HC

<400>  149

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Leu Thr Gly Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  150
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the Ab24_4422DA HC

<400>  150
gaggtgcagc tggtggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttccggctt caccttctcc agctacgtga tgtcctgggt ccgacagacc      120

cctggcaaag gactggaatg ggtcgccaca atctcctccg gcggcaccta cacctactat      180

cccgactctg tgaagggcag attcaccctg tccagagaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc ttctcagctg      300

accggctccg agttcgatta ttggggccag ggcaccaccg tgaccgtgtc ctctgcttct      360

accaagggac ccagcgtgtt ccctctggct ccttgctcca gatccacctc cgagtctaca      420

gctgctctgg gctgcctggt caaggactac tttcctgagc ctgtgacagt gtcctggaac      480

tctggcgctc tgacatccgg cgtgcacaca tttccagctg tgctgcagtc ctccggcctg      540

tactctctgt cctctgtcgt gacagtgccc tcctctagcc tgggcaccaa gacctatacc      600

tgcaatgtgg accacaagcc ttccaacacc aaggtggaca agcgcgtgga atctaagtac      660

ggccctcctt gtcctccatg tcctgctcct ccagtggctg gcccttccgt gtttctgttc      720

cctccaaagc ctaaggacac cctgatgatc tctcggaccc ctgaagtgac ctgcgtggtg      780

gtggctgtgt ctcacgagga tcctgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaatg ccaagaccaa gcctagagag gaacagttca actccacctt cagagtggtg      900

tccgtgctga ccgtggtgca tcaggattgg ctgaacggca aagagtacaa gtgcaaggtg      960

tccaacaagg gcctgcctgc tcctatcgaa aagaccatct ctaagaccaa ggggcagccc     1020

cgggaacctc aggtttacac actgcctcca agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gcctcgtgaa gggcttctac ccttccgata tcgccgtgga atgggagtcc     1140

aatggccagc cagagaacaa ctacaagacc acacctccta tgctggactc cgacggctca     1200

ttcttcctgt actccaagct gacagtggac aagtccagat ggcagcaggg caacgtgttc     1260

tcctgcagcg tgatgcacga ggccctgcac aatcactaca cccagaagtc cctgtctctg     1320

agccctggca ag                                                         1332


<210>  151
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature amino acid sequence of the Ab24_4422DA HC

<400>  151

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Leu Thr Gly Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  152
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding the Ab24_AAA HC

<400>  152
gaggtgcagc tggtggaatc tggcggagga cttgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cttccggctt caccttctcc agctacgtga tgtcctgggt ccgacagacc      120

cctggcaaag gactggaatg ggtcgccaca atctcctccg gcggcaccta cacctactat      180

cccgactctg tgaagggcag attcaccctg tccagagaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc ttctcagctg      300

accggctccg agttcgatta ttggggccag ggcaccaccg tgaccgtgtc ctctgcttct      360

accaagggac ccagcgtgtt ccctctggct ccttccagca agtctacctc tggcggaaca      420

gctgctctgg gctgcctggt caaggactac tttcctgagc ctgtgacagt gtcctggaac      480

tctggcgctc tgacatccgg cgtgcacaca tttccagctg tgctgcagtc ctccggcctg      540

tactctctgt cctctgtcgt gacagtgccc tccagctctc tgggaaccca gacctacatc      600

tgcaatgtga accacaagcc ttccaacacc aaggtggaca agaaggtgga acccaagtcc      660

tgcgacaaga cccacacctg tcctccatgt cctgctccag aagctgctgg cggcccttcc      720

gtgtttctgt tccctccaaa gcctaaggac accctgatga tctctcggac ccctgaagtg      780

acctgcgtgg tggtggatgt gtctcacgag gatcccgaag tgaagttcaa ttggtacgtg      840

gacggcgtgg aagtgcacaa tgccaagacc aagcctagag aggaacagta caactccacc      900

tacagagtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaagagtac      960

aagtgcaagg tgtccaacaa ggccctggcc gctcctatcg aaaagaccat ctccaaggcc     1020

aagggccagc ctagggaacc ccaggtttac accctgcctc caagccggga agagatgacc     1080

aagaaccagg tgtccctgac ctgcctcgtg aagggcttct acccttccga tatcgccgtg     1140

gaatgggaga gcaatggcca gccagagaac aactacaaga caacccctcc tgtgctggac     1200

tccgacggct cattcttcct gtactccaag ctgacagtgg acaagtccag atggcagcag     1260

ggcaacgtgt tctcctgcag cgtgatgcac gaggccctgc acaatcacta cacccagaag     1320

tccctgtctc tgagccctgg caag                                            1344


<210>  153
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature amino acid sequence of the Ab24_AAA HC

<400>  153

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Leu Thr Gly Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


