                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Liu, Bin
       Lee, Namkyung
       Su, Yang
       Bidlingmaier, Scott
 
<120>  Compositions and Methods for Modulating Cellular Internalization

<130>  048536-628001WO

<140>  Herewith
<141>  Herewith

<150>  US 62/792,359
<151>  2019-01-14

<160>  110    

<170>  PatentIn version 3.5

<210>  1
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  2
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(31)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (88)..(97)
<223>  LCDR3

<400>  2

Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  3
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  4
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(31)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (88)..(97)
<223>  LCDR3

<400>  4

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  5
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  6
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(31)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (88)..(97)
<223>  LCDR3

<400>  6

Gln Ser Ala Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  7
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  8
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(31)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (88)..(97)
<223>  LCDR3

<400>  8

Gln Ser Val Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105         


<210>  9
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  10
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(31)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (88)..(97)
<223>  LCDR3

<400>  10

Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  11
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  12
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(31)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (88)..(97)
<223>  LCDR3

<400>  12

Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Glu Ser Leu Arg Arg Tyr Tyr Gly 
            20                  25                  30          


Ser Trp Tyr His Gln Arg Pro Gly Gln Ala Pro Leu Leu Val Phe Tyr 
        35                  40                  45              


Gly Lys Asn Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asp Thr Ala Thr Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Gly Ala Phe Tyr Cys Asn Ser Arg Asp Gly Ser Ala Asn His 
                85                  90                  95      


Phe Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105         


<210>  13
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  14
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  14

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Thr Asp Ile Gly Tyr Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Thr Ser Ser 
                85                  90                  95      


Thr Thr Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  15
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  HCDR3

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  16
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(101)
<223>  LCDR3

<400>  16

Gln Ser Ala Leu Thr Gln Pro Ala Ser Met Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Met Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Ser 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Thr Ser Ser 
                85                  90                  95      


Thr Thr Leu Val Val Phe Gly Gly Gly Thr Lys Ile Thr Val Leu 
            100                 105                 110     


<210>  17
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  18
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(101)
<223>  LCDR3

<400>  18

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  19
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  H(26)..(33)
<223>  CDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  20
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(101)
<223>  LCDR3

<400>  20

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  21
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  21

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  22
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(101)
<223>  LCDR3

<400>  22

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp His Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Ser Leu Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  23
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  23

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  24
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  24

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Thr Ser Ser 
                85                  90                  95      


Asn Thr Arg Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  25
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  26
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  26

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Thr Ser Ser 
                85                  90                  95      


Asn Thr Arg Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  27
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  27

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  28
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  28

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Arg Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Arg His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Gly Ser Ser 
                85                  90                  95      


Asn Ala Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  29
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  30
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(101)
<223>  LCDR3

<400>  30

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Arg Asp Val Gly Gly Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Phe 
        35                  40                  45              


Ile Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Ile Cys Ser Ser Phe Thr Met Tyr 
                85                  90                  95      


Ser Thr Pro Val Ile Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  31
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  32
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(101)
<223>  LCDR3

<400>  32

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Arg Asp Val Gly Gly Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Phe 
        35                  40                  45              


Ile Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Ile Cys Ser Ser Phe Thr Met Tyr 
                85                  90                  95      


Ser Thr Pro Val Ile Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  33
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  33

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  34
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(101)
<223>  LCDR3

<400>  34

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Asn Phe 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala His Tyr Tyr Cys Asn Ser Tyr Thr Asn Ser 
                85                  90                  95      


Asp Ala Leu Ile Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  35
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  35

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  36
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(101)
<223>  LCDR3

<400>  36

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Leu Gly Arg Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Gly Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Ala Arg Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ser Thr Ala Ser Leu Thr Ile Ala Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Val Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Val Val Phe Gly Ala Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  37
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  38
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(101)
<223>  LCDR3

<400>  38

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Leu Gly Arg Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Gly Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Ala Arg Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ser Thr Ala Ser Leu Thr Ile Ala Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Val Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Val Val Phe Gly Ala Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  39
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  39

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  40
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(31)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (88)..(96)
<223>  LCDR3

<400>  40

Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser Val Ala Met Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Arg Arg Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Arg Pro Gly Gln Ala Pro Leu Leu Val Phe Tyr 
        35                  40                  45              


Gly Ser Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Ile Ser Ala Ser 
    50                  55                  60                  


Phe Thr Trp Asp Lys Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Met Ser Gly Asp Leu Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  41
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  42
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(31)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (88)..(96)
<223>  LCDR3

<400>  42

Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser Val Ala Met Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Arg Arg Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Arg Pro Gly Gln Ala Pro Leu Leu Val Phe Tyr 
        35                  40                  45              


Gly Ser Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Ile Ser Ala Ser 
    50                  55                  60                  


Phe Thr Trp Asp Lys Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Met Ser Gly Asp Leu Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  43
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  44
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(31)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (88)..(96)
<223>  LCDR3

<400>  44

Asn Phe Met Leu Thr Gln Pro Pro Ser Leu Ser Val Pro Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Ser Cys Thr Ala Asp Arg Leu Gly Ser Arg Tyr Val 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ser Pro Val Leu Ile Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Val Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly His Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Pro Val 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Thr Trp Asp Ser Gly Thr Val Ala 
                85                  90                  95      


Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105     


<210>  45
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  45

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  46
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (27)..(33)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (51)..(53)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(99)
<223>  LCDR3

<400>  46

Arg Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Ala Ile Ser Cys Ser Gly Asp Asn Thr Glu Ile Tyr Asn 
            20                  25                  30          


Tyr Val Ala Trp Tyr Gln Gln Leu Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Thr Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Phe Ser His Glu Gly Ser Phe 
                85                  90                  95      


Ser Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  47
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  48
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (27)..(33)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (51)..(53)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(99)
<223>  LCDR3

<400>  48

Arg Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Ala Ile Ser Cys Ser Gly Asp Asn Thr Glu Ile Tyr Asn 
            20                  25                  30          


Tyr Val Ala Trp Tyr Gln Gln Leu Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Thr Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Phe Ser His Glu Gly Ser Phe 
                85                  90                  95      


Ser Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  49
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  49

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  50
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  50

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Tyr Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Arg Tyr Val Ser Trp Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Asp Thr Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Asp Ser Asp Tyr Tyr Cys Phe Ser Tyr Ala Gly Ser 
                85                  90                  95      


Leu Thr Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  51
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  51

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  52
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  52

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Asn Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Arg Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asp Phe Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  53
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  54
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  54

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Asn Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Arg Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asp Phe Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  55
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  55

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  56
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  56

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Arg Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile His Glu Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Asn 
                85                  90                  95      


Tyr Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  57
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  58
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  58

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Arg Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile His Glu Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Asn 
                85                  90                  95      


Tyr Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  59
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  59

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  60
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  60

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Thr Cys Thr Gly Thr Ser Ser Asp Ile Gly His Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr His Gln Val Pro Gly Lys Ala Pro Thr Leu 
        35                  40                  45              


Leu Ile Ser Gln Val Thr Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Arg Thr Glu Asp Glu Gly Asp Tyr Tyr Cys Ser Ser Tyr Val Gly Asn 
                85                  90                  95      


Asn Asn Tyr Val Phe Gly Arg Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  61
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  62
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  62

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Thr Cys Thr Gly Thr Ser Ser Asp Ile Gly His Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr His Gln Val Pro Gly Lys Ala Pro Thr Leu 
        35                  40                  45              


Leu Ile Ser Gln Val Thr Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Arg Thr Glu Asp Glu Gly Asp Tyr Tyr Cys Ser Ser Tyr Val Gly Asn 
                85                  90                  95      


Asn Asn Tyr Val Phe Gly Arg Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  63
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  63

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  64
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  64

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Gly Asp Ile Gly Gly Phe 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Arg His His Pro Gly Arg Ala Pro Gln Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Asp Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ser Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ser Asp Tyr Tyr Cys Tyr Ser Tyr Ala Gly Asn 
                85                  90                  95      


Tyr His Gly Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  65
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  66
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  66

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Gly Asp Ile Gly Gly Phe 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Arg His His Pro Gly Arg Ala Pro Gln Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Asp Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ser Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ser Asp Tyr Tyr Cys Tyr Ser Tyr Ala Gly Asn 
                85                  90                  95      


Tyr His Gly Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  67
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR2

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  68
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (27)..(32)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (50)..(52)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (89)..(98)
<223>  LCDR3

<400>  68

Val Ile Trp Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asn Phe Ser Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Ser Phe Pro Ser 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Arg Glu Ile Lys 
            100                 105             


<210>  69
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  70
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (27)..(32)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (50)..(52)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (89)..(98)
<223>  LCDR3

<400>  70

Val Ile Trp Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asn Phe Ser Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Ser Phe Pro Ser 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Arg Glu Ile Lys 
            100                 105             


<210>  71
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(104)
<223>  HCDR3

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  72
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (27)..(32)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (50)..(52)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (89)..(98)
<223>  LCDR3

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Ser Phe Pro Ser 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Arg Glu Ile Lys 
            100                 105             


<210>  73
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(110)
<223>  HCDR3

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asp Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Arg Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gly Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Gly Gly Gln Gly Tyr Ser Gly Tyr Asp Gly Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  74
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (51)..(53)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (90)..(100)
<223>  LCDR3

<400>  74

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Thr His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Leu 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  75
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(110)
<223>  HCDR3

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asp Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Arg Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Gly Gly Gln Gly Tyr Ser Gly Tyr Asp Gly Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  76
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (51)..(53)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (90)..(100)
<223>  LCDR3

<400>  76

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  77
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(110)
<223>  HCDR3

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asp Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Arg Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gly Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Gly Gly Gln Gly Tyr Ser Gly Tyr Asp Gly Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  78
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (51)..(53)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (90)..(100)
<223>  LCDR3

<400>  78

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Thr His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Leu 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Lys Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Gly Val Phe Gly Gly Gly Thr Gln Arg Thr Val Leu 
            100                 105                 110 


<210>  79
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(110)
<223>  HCDR3

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asp Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Arg Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Gly Gly Gln Gly Tyr Ser Gly Tyr Asp Gly Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  80
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(33)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (51)..(53)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (90)..(100)
<223>  LCDR3

<400>  80

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Lys Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Gly Val Phe Gly Gly Gly Thr Gln Arg Thr Val Leu 
            100                 105                 110 


<210>  81
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (23)..(35)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (50)..(59)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(115)
<223>  HcDR3

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Arg Leu Pro Asn Phe Trp Ser Gly Tyr Pro Asn Tyr Gly 
            100                 105                 110         


Thr Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  82
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (23)..(36)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(102)
<223>  LCDR3

<400>  82

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  83
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (23)..(35)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (50)..(59)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(115)
<223>  HCDR3

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Arg Leu Pro Asn Phe Trp Ser Gly Tyr Pro Asn Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  84
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (23)..(36)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(102)
<223>  LCDR3

<400>  84

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  85
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (23)..(35)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (50)..(59)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(115)
<223>  HCDR3

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Arg Leu Pro Asn Phe Trp Ser Gly Tyr Pro Asn Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  86
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (23)..(36)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(102)
<223>  LCDR3

<400>  86

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  87
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (23)..(35)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (50)..(59)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(115)
<223>  HCDR3

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Arg Phe Pro Asp Phe Trp Ser Gly Tyr Pro Asn Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  88
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (23)..(36)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(102)
<223>  LCDR3

<400>  88

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  89
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (23)..(35)
<223>  HCDR1

<220>
<221>  misc_feature
<222>  (50)..(59)
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (97)..(115)
<223>  HCDR3

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Arg Leu Pro Asp Phe Trp Ser Gly Tyr Pro Asn Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  90
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (23)..(36)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (51)..(58)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(102)
<223>  LCDR3

<400>  90

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  91
<211>  759
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  encodes the peptide sequence of RYRgerm_102919_15

<400>  91
gaggtgcagc tggttgagtc gggaggaggt ttggtacagc ctggaggttc cctgagactc       60

tcctgtgcag cctctggatt caccttctcg agctatagca tgaactgggt ccgccaggct      120

ccaggtaagg gactggagtg ggtttcatac atttctagtt caagtagtac catatactac      180

gcagactctg tgaagggacg attcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gaggtatcga      300

ttaccgaatt tttggagtgg ttaccctaac tacggtacgg acgtctgggg acaaggaaca      360

acagtcacag tttcatcagg tggaggaggt tcaggtggag gtggctctgg aggtggtgga      420

tctcagtctg ttttgacgca gccgccctca gtgtctggtg ccccagggca gagggtcacc      480

atctcctgca ctggaagcag ctccaacatc ggtgcaggtt atgatgtaca ctggtaccag      540

cagcttccag gaacagcccc caaactcctc atctatggta acagcaatcg gccctcagga      600

gttcctgacc gattctctgg atccaagtct ggtacctcag cctccctggc catcactgga      660

ctccaggctg aggatgaggc tgattattac tgccagtcct atgacagcag cctgtccgga      720

catgtggtat tcggtggagg aaccaagctg accgtccta                             759


<210>  92
<211>  759
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  encodes the peptide sequence of RYRgerm_102919_14

<400>  92
gaggtgcagc tggttgagtc gggaggaggt ttggtacagc ctggaggttc cctgagactc       60

tcctgtgcag cctctggatt cacctcctcg agctatagca tgaactgggt ccgccaggct      120

ccaggtaagg gactggagtg ggtttcatac atttctagtt caagtagtac catatactac      180

gcagactctg tgaagggacg attcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gaggtatcga      300

ttaccgaatt tttggagtgg ttaccctaac tacggtatgg acgtctgggg acaaggaaca      360

acagtcacag tttcatcagg tggaggaggt tcaggtggag gtggctctgg aggtggtgga      420

tctcagtctg ttttgacgca gccgccctca gtgtctggtg ccccagggca gagggtcacc      480

atctcctgca ctggaagcag ctccaacatc ggtgcaggtt atgatgtaca ctggtaccag      540

cagcttccag gaacagcccc caaactcctc atctatggta acagcaatcg gccctcagga      600

gttcctgacc gattctctgg atccaagtct ggtacctcag cctccctggc catcactgga      660

ctccaggctg aggatgaggc tgattattac tgccagtcct atgacagcag cctgtccgga      720

catgtggtat tcggtggagg aaccaagctg accgtccta                             759


<210>  93
<211>  759
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  encodes the peptide sequence of RYRgerm_102919_22

<400>  93
gaggtgcagc tggtggagtc tggtggagga ttggtacagc ctggaggttc cctgagactc       60

tcctgcgcag cctctggatt caccttctcg agctatagca tgaactgggt ccgccaggct      120

ccaggtaagg gactggagtg ggtttcatac atttctagtt caagtagtac catatactac      180

gcagactctg tgaagggacg attcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gaggtatcga      300

ttaccgaatt tttggagtgg ttaccctaac tacggtatgg acgtctgggg acaaggaaca      360

acagtcacag tttcatcagg tggaggaggt tcaggtggag gtggctctgg aggtggtgga      420

tctcagtctg ttttgacgca gccgccctca gtgtctggtg ccccagggca gagggtcacc      480

atctcctgca ctggaagcag ctccaacatc ggtgcaggtt atgatgtaca ctggtaccag      540

cagcttccag gaacagcccc caaactcctc atctatggta acagcaatcg gccctcagga      600

gttcctgacc gattctctgg atccaagtct ggtacctcag cctccctggc catcactgga      660

ctccaggctg aggatgaggc tgattattac tgccagtcct atgacagcag cctgtccgga      720

catgtggtat tcggtggagg aaccaagctg accgtccta                             759


<210>  94
<211>  759
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<223>  encodes the peptide sequence of RYRgerm_102919_33

<400>  94
gaggtgcagc tggttgagtc gggaggaggt ttggtacagc ctggaggttc cctgagactc       60

tcctgtgcag cctctggatt caccttctcg agctatagca tgaactgggt ccgccaggct      120

ccaggtaagg gactggagtg ggtttcatac atttctagtt caagtagtac catatactac      180

gcagactctg tgaagggacg attcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gaggtatcga      300

tttccggatt tttggagtgg ttaccctaac tacggtatgg acgtctgggg acaaggaaca      360

acagtcacag tttcatcagg tggaggaggt tcaggtggag gtggctctgg aggtggtgga      420

tctcagtctg ttttgacgca gccgccctca gtgtctggtg ccccagggca gagggtcacc      480

atctcctgca ctggaagcag ctccaacatc ggtgcaggtt atgatgtaca ctggtaccag      540

cagcttccag gaacagcccc caaactcctc atctatggta acagcaatcg gccctcagga      600

gttcctgacc gattctctgg atccaagtct ggtacctcgg cctccctggc catcactgga      660

ctccaggctg aggatgaggc tgattattac tgccagtcct atgacagcag cctgtccgga      720

catgtggtat tcggtggagg aaccaagctg accgtccta                             759


<210>  95
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<222>  (26)..(34)
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (91)..(100)
<223>  LCDR3

<400>  95

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Arg His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Pro Tyr Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  96
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  96

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Arg Leu Pro Asp Phe Trp Ser Gly Tyr Pro Asn Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  97
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  97

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly His Val Val Phe Gly Gly Gly Thr 
            100                 105         


<210>  98
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  98

Gly Phe Thr Leu Ser Asp Tyr Ser 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  99

Ile Ser Ser Arg Ser Ser Tyr Ile 
1               5               


<210>  100
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  100

Thr Gly Gly Gln Gly Tyr Ser Gly Tyr Asp Gly Phe Gln His 
1               5                   10                  


<210>  101
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  101

Ser Ser Asn Ile Gly Ser Asn Ser 
1               5               


<210>  102
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<220>
<221>  misc_feature
<223>  CDR2 OF 3F1 VL

<400>  102

Ser Asn Thr 
1           


<210>  103
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  103

Ala Ser Trp Asp Asp Ser Leu Asn Gly Gly Val 
1               5                   10      


<210>  104
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  104

Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   10              


<210>  105
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  105

Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr 
1               5                   10  


<210>  106
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  106

Ala Arg Tyr Arg Leu Pro Asp Phe Trp Ser Gly Tyr Pro Asn Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  107
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  107

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  108
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  108

Tyr Gly Asn Ser Asn Arg Pro Ser 
1               5               


<210>  109
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  109

Gln Ser Tyr Asp Ser Ser Leu Ser Gly His Val Val 
1               5                   10          


<210>  110
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  110

Ala Arg Tyr Arg Leu Pro Asn Phe Trp Ser Gly Tyr Pro Asn Tyr Gly 
1               5                   10                  15      


Thr Asp Val 
            
