                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       ZEMACH, Assaf
       OHAD, Nir
       YAARI, Rafael
       KATZ, Aviva
       DOMB, Katherine
 
<120>  PLANT DNA METHYLTRANSFERASES AND USES THEREOF

<130>  81636

<150>  US 62/813,805
<151>  2019-03-05

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  332
<212>  PRT
<213>  Klebsormidium flaccidum

<400>  1

Val Val Ser Met Phe Asp Gly Met Gly Gly Cys Trp Gln Ala Leu Lys 
1               5                   10                  15      


Ala Leu Gly Ile Pro Val Lys Lys Gly Tyr Ser Cys Glu Ile Lys Glu 
            20                  25                  30          


Phe Ala Asn Ala Val Val Lys Glu Arg Phe Pro Asp Val Ile His Leu 
        35                  40                  45              


Gly Ser Val Thr Ala Val Thr Gln Asp Met Ile Pro Glu Pro Val Asp 
    50                  55                  60                  


Leu Ile Val Ala Gly Phe Pro Cys Gln Asp Leu Ser Ser Met Gly Asn 
65                  70                  75                  80  


Gln Arg Gly Leu His Gly Ala Arg Ser Gly Leu Phe Phe His Ile Pro 
                85                  90                  95      


Arg Phe Ile Ser Met Phe Lys Ala Lys Trp Phe Leu Val Glu Asn Val 
            100                 105                 110         


Lys Cys Arg Trp Gln Asp Gln Ala Glu Ile Thr Lys Tyr Leu Leu Asn 
        115                 120                 125             


Val Leu Pro Leu Glu Leu Asp Ala Glu Glu Leu Ser Pro Gln Ser Arg 
    130                 135                 140                 


Val Arg Asn Tyr Trp Thr Asn Leu Pro Leu Pro Pro Asn Leu Pro Gly 
145                 150                 155                 160 


Ile Arg Asp Ala Pro Glu Thr Ser Val Gln His Phe Leu Glu Asn Ala 
                165                 170                 175     


Ile Ala Pro Phe Val Lys Thr Gly Thr Val Met Thr Thr Asn Asn Asp 
            180                 185                 190         


Ala Asn Thr Ser Asn Cys Ala Leu Lys Ser Ile Tyr Asp Leu Ala Ser 
        195                 200                 205             


Gly Gly Ala Arg Tyr Leu Glu Val Glu Glu Ile Glu Ala Met Met Gly 
    210                 215                 220                 


Tyr Ser Ala Gly Tyr Ser Lys Ile Pro Tyr Asn Lys His Gly Cys Ile 
225                 230                 235                 240 


Leu Pro Phe Ser Ser Ser Lys Lys Gln Ser Gly Arg Arg Arg Cys Ser 
                245                 250                 255     


Gln Gly Gly Ala Ser Glu Gly Ala Asn Gly Gly Gly Ala Glu Gly Pro 
            260                 265                 270         


Pro Gln Lys Arg Pro Gly Arg Arg Pro Thr Pro Lys Arg Arg Ser Gln 
        275                 280                 285             


Ser Thr Pro Arg Arg Lys Leu Leu Ser Pro Gly Ser Ser Gly Glu Ala 
    290                 295                 300                 


Leu Phe Ala Thr Lys Asp Leu Arg Trp Glu Leu Leu Gly Asn Ser Phe 
305                 310                 315                 320 


Val Val Pro Cys Ile Ala Tyr Met Leu Ser Gln Leu 
                325                 330         


<210>  2
<211>  207
<212>  PRT
<213>  Selaginella moellendorffii

<400>  2

Val Leu Ser Leu Phe Asp Gly Ile Gly Gly Thr Trp Ala Ala Leu Asp 
1               5                   10                  15      


Arg Leu Glu Val Arg Tyr Lys Gly Tyr Ser Ser Glu Ile Asn Pro Tyr 
            20                  25                  30          


Ala Ala Arg Val Leu Lys Ala Lys Phe Pro Asn Val Thr His Leu Gly 
        35                  40                  45              


Asp Val Lys Asp Ile Arg Arg Gly Asp Ile Glu Glu Glu Ile Asp Leu 
    50                  55                  60                  


Val Val Gly Gly Phe Pro Cys Gln Asp Leu Thr Ser Met Gly Lys Arg 
65                  70                  75                  80  


Asp Gly Phe Leu Val Glu Asn Val Ala Ser Met Thr Trp Ile Asp Arg 
                85                  90                  95      


Glu Glu Ile Ser Lys Tyr Leu Asn Cys Leu Pro Ile Glu Ile Asp Ser 
            100                 105                 110         


Gln Asp Leu Thr Ala Ser Lys Arg Lys Arg Leu Tyr Trp Thr Asn Ile 
        115                 120                 125             


Pro His Pro Glu Lys Leu Pro Asp Val Arg Asn His Ala Ser Asn Leu 
    130                 135                 140                 


Leu Gln His Ala Leu Asp Asp Ala Thr Ala Leu Glu Glu Lys Ile Gly 
145                 150                 155                 160 


Cys Val Met Thr Cys Asn Tyr Tyr Val Gly Gly Phe Gly Gln Leu Gln 
                165                 170                 175     


Arg Val Phe Asp Arg Lys Asp Lys Val Leu Arg Tyr Val Thr Val Thr 
            180                 185                 190         


Glu Leu Glu Lys Val Thr Val Ile Ser Tyr Met Leu Ser Pro Leu 
        195                 200                 205         


<210>  3
<211>  258
<212>  PRT
<213>  Selaginella moellendorffii

<400>  3

Val Leu Ser Leu Phe Asp Gly Ile Gly Gly Thr Trp Ala Ala Leu Asp 
1               5                   10                  15      


Arg Leu Glu Val Arg Tyr Lys Gly Tyr Ser Ser Glu Ile Asn Pro Tyr 
            20                  25                  30          


Ala Ala Arg Val Leu Lys Ala Lys Phe Pro Asn Val Thr His Leu Gly 
        35                  40                  45              


Asp Val Lys Asp Ile Arg Arg Gly Asp Ile Glu Glu Glu Ile Asp Leu 
    50                  55                  60                  


Val Val Gly Gly Phe Pro Cys Gln Asp Leu Thr Ser Met Gly Lys Arg 
65                  70                  75                  80  


Asp Gly Phe Leu Val Glu Asn Val Ala Ser Met Thr Trp Ile Asp Arg 
                85                  90                  95      


Glu Glu Ile Ser Lys Tyr Leu Asn Cys Leu Pro Ile Glu Ile Asp Ser 
            100                 105                 110         


Gln Asp Leu Thr Ala Ser Lys Arg Lys Arg Leu Tyr Trp Thr Asn Ile 
        115                 120                 125             


Pro His Pro Glu Lys Leu Pro Asp Val Arg Asn His Ala Ser Asn Leu 
    130                 135                 140                 


Leu Gln His Ala Leu Asp Asp Ala Thr Ala Leu Glu Glu Lys Ile Gly 
145                 150                 155                 160 


Cys Val Met Thr Cys Asn Tyr Tyr Val Gly Gly Phe Gly Gln Leu Gln 
                165                 170                 175     


Arg Val Phe Asp Arg Lys Asp Glu Val Leu Arg Tyr Val Thr Val Thr 
            180                 185                 190         


Glu Leu Glu Lys Val Met Gly Phe Pro Ala Gly His Thr Asp Ile Asp 
        195                 200                 205             


Phe Gly Asn Leu Asp Asp Phe Val Pro Phe Ala Ser Glu Gln Thr Pro 
    210                 215                 220                 


Lys Arg Lys Cys Lys Leu Asp Asp Lys Ala Lys Thr Ile Arg Trp Asn 
225                 230                 235                 240 


Leu Ile Gly Asn Ser Phe Ser Val Ser Val Ile Ser Tyr Met Leu Ser 
                245                 250                 255     


Pro Leu 
        


<210>  4
<211>  319
<212>  PRT
<213>  Physcomitrella patens

<400>  4

Val Leu Ser Leu Phe Asp Gly Leu Gly Gly Ile Trp Gln Ala Leu Thr 
1               5                   10                  15      


Asn Leu Gly Ile Pro Phe Ser Gly Tyr Ser Ser Glu Val Leu Ala Pro 
            20                  25                  30          


Ala Ile Gln Val Val Lys Ser Arg His Pro His Val Lys His Val Gly 
        35                  40                  45              


Asp Val Arg Lys Leu Asn Leu Ser Ala Ile Pro Glu Lys Val Asp Leu 
    50                  55                  60                  


Val Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Ile Met Gly Lys Lys 
65                  70                  75                  80  


Glu Gly Leu His Gly Ser Arg Ser Lys Leu Phe Phe Asp Leu Leu Arg 
                85                  90                  95      


Val Leu Gln Ile Phe Lys Pro Lys Trp Phe Leu Val Glu Asn Val Ala 
            100                 105                 110         


Ser Met Ser Trp Val Asp Arg Glu Glu Ile Thr Arg His Leu Lys Val 
        115                 120                 125             


Val Pro Met Glu Leu Asp Ser Gln Glu Ile Thr Ala Ser Lys Arg Arg 
    130                 135                 140                 


Arg Leu Tyr Trp Thr Asn Ile Pro His Pro Pro Arg Leu Pro Arg Leu 
145                 150                 155                 160 


Arg Asp His Pro Ser Thr Ser Leu Gln Ser Cys Leu Glu Gly Ala Leu 
                165                 170                 175     


Ala Leu Glu Gln Lys Cys Gly Val Val Leu Cys Asn Asn Leu Tyr Lys 
            180                 185                 190         


Gly Gly Gly Ala Arg Leu Glu Leu Val Leu Asp Asn Thr Ile Asn Lys 
        195                 200                 205             


Leu Arg Tyr Ile Lys Gln Thr Glu Ile Glu Leu Leu Met Gly Tyr Pro 
    210                 215                 220                 


Arg Asn Tyr Thr Asn Val Val Val Arg Arg Thr Lys Ile Thr Glu Lys 
225                 230                 235                 240 


Ile Ile Lys Ala Val Arg Ile Pro Glu Lys Pro Thr Val Ala Leu Pro 
                245                 250                 255     


Lys Ser Ser Pro Pro Gln Thr Pro Ser Ile Arg Gln Leu Arg Lys Asn 
            260                 265                 270         


Arg Thr Ser Arg Thr Phe Phe Ala Pro Gln Val Trp Glu Arg Asn Pro 
        275                 280                 285             


Thr Arg Gln Glu Ser Leu Lys Asp Leu Asp Arg Trp Phe Leu Leu Gly 
    290                 295                 300                 


Asn Ser Phe Ser Val Gln Val Ile Thr Tyr Leu Thr Ser Ser Leu 
305                 310                 315                 


<210>  5
<211>  320
<212>  PRT
<213>  Physcomitrella patens

<400>  5

Val Leu Ser Leu Phe Asp Gly Leu Gly Gly Ile Trp Gln Ala Leu Thr 
1               5                   10                  15      


Lys Leu Gly Ile Pro Phe Ser Gly Tyr Ser Ser Glu Val Leu Ala Pro 
            20                  25                  30          


Ala Ile Gln Val Val Lys Ser Arg His Pro Arg Val Lys His Val Gly 
        35                  40                  45              


Asp Ile Arg Lys Leu Asn Leu Ser Ala Val Pro Glu Lys Val Asp Leu 
    50                  55                  60                  


Val Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Ile Met Gly Lys Lys 
65                  70                  75                  80  


Glu Gly Leu His Gly Ser Arg Ser Lys Leu Phe Phe Asp Leu Leu Arg 
                85                  90                  95      


Val Leu Lys Val Phe Lys Pro Lys Trp Phe Leu Val Glu Asn Val Ala 
            100                 105                 110         


Ser Met Ser Trp Val Asp Arg Glu Glu Ile Thr Arg His Leu Lys Val 
        115                 120                 125             


Ala Pro Met Glu Leu Asp Ser Gln Glu Ile Thr Ala Ser Lys Arg Arg 
    130                 135                 140                 


Arg Leu Tyr Trp Thr Asn Ile Pro His Pro Pro Arg Leu Pro Arg Leu 
145                 150                 155                 160 


Arg Asp His Pro Ser Thr Ser Leu Gln Ser Cys Leu Glu Gly Ala Leu 
                165                 170                 175     


Ala Leu Glu Gln Lys Cys Gly Val Ile Leu Cys Ser Asn Leu Tyr Lys 
            180                 185                 190         


Gly Ser Thr Ala Arg Leu Glu Leu Val Leu Asp Asn Lys Thr Asn Lys 
        195                 200                 205             


Leu Arg Tyr Ile Lys Gln Thr Glu Val Glu Val Leu Met Gly Tyr Pro 
    210                 215                 220                 


Lys Asp Tyr Thr Asn Val Val Ala His Glu Thr Lys Gly Arg Thr Glu 
225                 230                 235                 240 


Gln Ala Glu Lys Val Leu Lys Thr Pro Val Arg Ala Lys Ser Val Glu 
                245                 250                 255     


Pro Lys Pro Ser Ser Val Thr Pro Pro Ser Ser Arg Gln Leu Arg Lys 
            260                 265                 270         


Asn Arg Lys Ser Gln Thr Phe Phe Val Pro Gln Val Trp Glu Thr Lys 
        275                 280                 285             


Pro Thr Arg Gln Asp Ser Leu Lys Asp Ile Asp Arg Trp Phe Leu Leu 
    290                 295                 300                 


Gly Asn Thr Phe Ser Val Gln Val Ile Ala Tyr Leu Thr Ser Pro Leu 
305                 310                 315                 320 


<210>  6
<211>  309
<212>  PRT
<213>  Sphagnum fallax

<400>  6

Val Leu Ser Leu Phe Asp Gly Ile Gly Gly Ile Trp Ala Ala Leu Thr 
1               5                   10                  15      


Arg Leu Gly Ile Pro Phe Thr Gly Tyr Ser Ser Glu Val Ser Ile Pro 
            20                  25                  30          


Ala Leu Glu Val Leu Lys Ala Lys Tyr Pro Glu Val His His Val Gly 
        35                  40                  45              


Asp Val Arg Lys Val Glu Arg Met Thr Val Ser Glu Lys Val Asp Leu 
    50                  55                  60                  


Val Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Cys Met Gly Lys Arg 
65                  70                  75                  80  


Glu Gly Leu His Gly Gln Arg Ser Lys Leu Phe Phe Asp Leu Leu His 
                85                  90                  95      


Val Leu Lys Ile Phe Asn Pro Ser Trp Phe Leu Val Glu Asn Val Ala 
            100                 105                 110         


Ser Met Thr Trp Met Asp Arg Asp Glu Ile Ser Lys Tyr Leu Lys Leu 
        115                 120                 125             


Gln Pro Ile Glu Leu Asp Ser Ile Glu Leu Ala Pro Ser Lys Arg Arg 
    130                 135                 140                 


Arg Leu Tyr Trp Thr Asn Ile Pro His Pro Ala Arg Leu Pro Arg Val 
145                 150                 155                 160 


Lys Asn His Pro Ser Thr Phe Val Gln Ser Cys Leu Leu Asp Gly Ile 
                165                 170                 175     


Ala Leu Glu Glu Lys Thr Gly Ile Ile Leu Ser Asn Asn Ser Tyr Lys 
            180                 185                 190         


Ser Asn Ser Cys Gln Met Glu Leu Val Leu Glu Asn Gly Thr Ser Glu 
        195                 200                 205             


Leu Arg Tyr Leu Ser His Val Glu Leu Glu Arg Ile Met Gly Tyr Pro 
    210                 215                 220                 


Ser Asn His Thr Ser Leu Cys Ile Asp Glu Ala Glu Asn Asn Ser Asn 
225                 230                 235                 240 


Pro Met Ile Ser Asn Val Ser Arg Tyr Val Gln Thr Ser Asn Thr Tyr 
                245                 250                 255     


His Lys Lys Arg Gly Lys Ile Cys Gly Val Gly Gly Pro Thr Arg Phe 
            260                 265                 270         


Cys Thr Pro Pro Ala Ser Thr Leu Gly Glu Pro Leu Lys Asp Ser Val 
        275                 280                 285             


Arg Trp Ala Leu Leu Gly Asn Thr Phe Thr Val Pro Val Ile Ala Tyr 
    290                 295                 300                 


Leu Val Ser Pro Leu 
305                 


<210>  7
<211>  299
<212>  PRT
<213>  Sphagnum fallax

<400>  7

Val Leu Ser Leu Phe Asp Gly Ile Gly Gly Ile Trp Ala Ala Leu Thr 
1               5                   10                  15      


Arg Leu Gly Ile Pro Phe Val Gly Tyr Ser Ser Glu Val Ser Pro Pro 
            20                  25                  30          


Ala Ile Gln Val Val Lys Ala Arg Tyr Pro Asp Val His His Val Gly 
        35                  40                  45              


Asp Val Arg Lys Leu Asp Arg Thr Ser Phe Ser Gly Asn Val Asp Leu 
    50                  55                  60                  


Val Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Ala Met Gly Arg Arg 
65                  70                  75                  80  


Glu Gly Leu His Gly Gln Arg Ser Lys Leu Phe Phe Asp Leu Leu Arg 
                85                  90                  95      


Val Leu Lys Glu Phe Lys Pro Lys Trp Phe Leu Val Glu Asn Val Ala 
            100                 105                 110         


Ser Met Thr Trp Ile Asp Arg Glu Glu Ile Ser Lys Tyr Leu Arg Val 
        115                 120                 125             


Tyr Pro Ile Glu Leu Asp Ser Ile Glu Leu Thr Pro Thr Arg Arg Arg 
    130                 135                 140                 


Arg Val Tyr Trp Thr Asn Ile Pro Tyr Pro Pro Arg Leu Pro Arg Val 
145                 150                 155                 160 


Lys Asp His Pro Ser Thr Phe Val Gln Ser Cys Leu His Asn Ala Ile 
                165                 170                 175     


Ala Leu Glu Glu Lys Thr Gly Val Val Met Gly Phe Gly Ser Asp Lys 
            180                 185                 190         


Ala Asn Ser Cys Leu Leu Glu His Val Met Asp Ile Glu Thr Arg Lys 
        195                 200                 205             


Met Arg Gly Ile Thr Gln Ile Glu Val Glu Val Met Met Gly Tyr Pro 
    210                 215                 220                 


Pro Asn His Thr Asn Leu Leu Ile Thr Glu Ala Lys His Gln Thr Asn 
225                 230                 235                 240 


Ala Leu Val Gln Thr Pro Ser Lys Met Gln Thr Ser Ser Ala Ser Lys 
                245                 250                 255     


Lys Lys Gln Gly Lys Ile Ser Gly Ser Arg Gly Ser Leu Ser Gln Asn 
            260                 265                 270         


Pro Ile Thr Pro Ala Ile Arg Trp Ala Leu Leu Gly Asn Thr Phe Thr 
        275                 280                 285             


Val Pro Thr Ile Gly Tyr Leu Ile Ser Pro Leu 
    290                 295                 


<210>  8
<211>  300
<212>  PRT
<213>  Encephalartos barteri

<400>  8

Val Leu Ser Leu Phe Asp Gly Ile Gly Ala Ile Trp Ala Ala Leu Ser 
1               5                   10                  15      


Leu Thr Gly Ile Pro Phe Val Gly Tyr Ser Ser Glu Ile Asn Pro Tyr 
            20                  25                  30          


Ala Arg Gln Ile Val Lys Glu Arg Tyr Pro Asp Val Lys Cys Leu Gly 
        35                  40                  45              


Asp Ile Lys Asn Ile Lys Lys Gly Asp Ile Asn Asp Asn Val Asp Phe 
    50                  55                  60                  


Ile Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Cys Met Gly Lys Lys 
65                  70                  75                  80  


Ala Gly Leu His Gly Asp Gln Ser Lys Leu Phe Phe Glu Leu Leu Arg 
                85                  90                  95      


Met Leu Gln Ile Phe Gln Pro Thr Trp Phe Leu Val Glu Asn Val Ala 
            100                 105                 110         


Ser Met Ser Trp Val Asp Arg Asp Glu Ile Ser Lys Tyr Leu Gly Cys 
        115                 120                 125             


Leu Pro Ile Glu Met Asp Ser Gln Asp Leu Thr Pro Thr Arg Arg Arg 
    130                 135                 140                 


Arg Leu Phe Trp Thr Asn Ile Pro His Pro Lys Ser Leu Pro Lys Val 
145                 150                 155                 160 


Arg Asp Asn Leu Ser Thr Ser Leu Gln Ser Val Leu Glu Asn Ala Ile 
                165                 170                 175     


Ala Leu Gln Ala Lys Thr Ala Cys Val Leu Ser Ala Asn His Ser Pro 
            180                 185                 190         


Gly Ser Ala Gly Gln Val Gln Gln Val Leu Asp Asp Lys Glu Gly Asn 
        195                 200                 205             


Leu Arg Ser Ile Thr Ile Ser Glu Leu Glu Lys Ile Met Gly Phe Pro 
    210                 215                 220                 


Pro Gly Tyr Thr Asp Phe Gln Phe Ser Phe Thr Ser Glu Thr Gln Ser 
225                 230                 235                 240 


Pro Lys Pro Ala Lys Thr Trp Ser Pro Asn Ser Pro Gly Lys Ser Glu 
                245                 250                 255     


Lys Pro Ile Lys Leu Ser Asp Pro Asp Gly Ser Ala Ile Thr Thr Glu 
            260                 265                 270         


Lys Val Thr Lys Tyr Asn Ile Arg Trp Arg Leu Leu Gly Asn Thr Phe 
        275                 280                 285             


Ser Val Lys Val Ile Val Tyr Leu Leu Ser Ser Leu 
    290                 295                 300 


<210>  9
<211>  215
<212>  PRT
<213>  Welwitschia mirabilis

<400>  9

Val Leu Ser Leu Phe Asp Gly Ile Gly Ala Ile Trp Glu Ala Leu Thr 
1               5                   10                  15      


Ile Leu Gly Ile Pro Phe Val Gly Tyr Ser Ser Glu Ile Asp Pro Cys 
            20                  25                  30          


Ala Ile Gln Val Val Lys Glu Arg Tyr Pro Lys Val Lys His Val Gly 
        35                  40                  45              


Asp Val Lys Asn Leu Lys Thr Glu Asp Ile Lys Glu Lys Val Asp Leu 
    50                  55                  60                  


Leu Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Ser Met Gly Arg Lys 
65                  70                  75                  80  


Val Gly Leu His Gly Glu Arg Ser Lys Leu Phe Phe Asp Leu Leu Gln 
                85                  90                  95      


Ala Met Gln Met Phe Glu Pro Tyr Trp Phe Leu Val Glu Asn Val Ala 
            100                 105                 110         


Ser Met Ser Trp Val Asp Arg Asp Glu Ile Cys Lys Tyr Ile Ala Cys 
        115                 120                 125             


Leu Pro Ile Glu Leu Asp Ser Gln Asp Leu Thr Pro Gly Lys Arg Arg 
    130                 135                 140                 


Arg Leu Tyr Trp Thr Asn Ile Pro Phe Pro Glu Thr Leu Pro Asn Val 
145                 150                 155                 160 


Arg Asp Asn Ser Ser Thr Ser Leu Gln Ser Val Leu Glu Asn Ala Thr 
                165                 170                 175     


Ala Leu Gln Thr Lys Thr Lys Cys Ile Met Ser Ser Ser Ser Lys Ile 
            180                 185                 190         


Gly Lys Met Gly Ser Phe Gln Gln Val Leu Asn Asn Asn Asp Gly Thr 
        195                 200                 205             


Leu Arg Asp Val Ser Val Thr 
    210                 215 


<210>  10
<211>  297
<212>  PRT
<213>  Marchantia polymorpha

<400>  10

Phe Val Gly Tyr Ser Cys Glu Val Asn Asp Ala Ala Met Gln Val Ile 
1               5                   10                  15      


Lys His Arg Tyr Gly Met Val Arg His Leu Gly Asp Val Lys Glu Leu 
            20                  25                  30          


Glu Lys Ala Asp Ile Pro Glu Lys Val Asp Leu Ile Ile Gly Gly Phe 
        35                  40                  45              


Pro Cys Gln Asp Leu Ser Ser Leu Gly His Lys Met Gly Leu His Gly 
    50                  55                  60                  


Gln Arg Ser Lys Leu Phe Phe Glu Met Leu Arg Ile Ile Lys Ile Phe 
65                  70                  75                  80  


Asn Pro Thr Trp Phe Leu Ala Glu Asn Val Ala Ser Met Thr Trp Ile 
                85                  90                  95      


Asp Arg Gln Glu Ile Ser Lys His Leu Asn Thr Thr Pro Ile Glu Ile 
            100                 105                 110         


Asp Ala Glu Glu Ile Thr Pro Ser Lys Arg Arg Arg Ile Tyr Trp Ser 
        115                 120                 125             


Asn Ile Pro Tyr Pro Asn Lys Ile Pro Arg Ile Arg Asp His Glu Ser 
    130                 135                 140                 


Thr Ala Leu Gln Ser Val Leu His Asn Ala Thr Ala Leu Asp Lys Lys 
145                 150                 155                 160 


Val Gly Cys Ile Leu Ser Gln Asn Asn His Lys Ala Gly Tyr Gly Ser 
                165                 170                 175     


Leu Glu Leu Val Met Asp Asn Asn Thr Asn Lys Leu Arg Tyr Ile Ser 
            180                 185                 190         


Val Ile Glu Thr Glu Leu Ala Met Gly Tyr Pro Pro Gly Tyr Thr Asn 
        195                 200                 205             


Val Lys Phe Asn His Ser Cys Glu Lys Lys Thr Ile Ser Ser Thr Ala 
    210                 215                 220                 


Asn Tyr Arg Thr Glu Val Asn Ile Thr Asn Ile Thr Arg Arg Ala Gly 
225                 230                 235                 240 


Glu Lys Met Leu Arg Ser Lys Arg Ile Val Gln Ser Ser Gln Arg Leu 
                245                 250                 255     


Val Glu Glu Met Ser Ser Val Lys Ser Ser Ser Phe Ala Asp Gly Ile 
            260                 265                 270         


Asn Arg Ser Ala Arg Trp His Leu Leu Gly Asn Thr Phe Ser Val Pro 
        275                 280                 285             


Val Ile Cys Tyr Leu Leu Ser Pro Leu 
    290                 295         


<210>  11
<211>  280
<212>  PRT
<213>  Marchantia polymorpha

<400>  11

Val Leu Ser Leu Phe Asp Gly Ile Gly Gly Val Trp Ala Ala Leu Glu 
1               5                   10                  15      


Asn Leu Gly Ile Pro Phe Ile Gly Tyr Ser Cys Glu Val Asn Ala Asp 
            20                  25                  30          


Ala Met Lys Val Thr Gln Arg Asn Tyr Cys Ser Val Arg His Leu Gly 
        35                  40                  45              


Asp Ile His Arg Leu Lys Lys Ala Asp Ile Lys Glu Lys Ile Asp Leu 
    50                  55                  60                  


Val Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Ser Met Gly Ala Arg 
65                  70                  75                  80  


Leu Gly Leu His Gly Ser Arg Ser Arg Leu Phe Phe Glu Met Leu Arg 
                85                  90                  95      


Val Ile Lys Thr Phe Ser Pro Thr Trp Phe Leu Ala Glu Asn Val Ala 
            100                 105                 110         


Ser Met Ser Trp Val Asp Arg Glu Glu Ile Ser Lys His Leu Ser Thr 
        115                 120                 125             


Thr Pro Leu Glu Ile Asp Ser Gln Asn Phe Ser Pro Cys Lys Arg Arg 
    130                 135                 140                 


Arg Leu Tyr Trp Ser Asn Ile Pro Tyr Pro Lys Thr Cys Pro Arg Ile 
145                 150                 155                 160 


Gly Asp Asn Glu Ala Thr Ser Ile Gln Ser Val Val Gln Gly Gly Ala 
                165                 170                 175     


Ser Leu Ala Lys Lys Asn Met Cys Val Leu Ser Ser Asn Gly Leu Gln 
            180                 185                 190         


Gly Ala Thr Lys Ala Leu Met Glu Leu Val Tyr Asp Phe Arg Ile Asp 
        195                 200                 205             


Lys Pro Arg Tyr Ile Asn Val Val Glu Val Glu Gln Met Met Gly Tyr 
    210                 215                 220                 


Pro Pro His Tyr Thr Asn Val Lys Phe Asp Asp Gln Lys Pro Lys Ala 
225                 230                 235                 240 


Lys Ile Gln Arg Arg Arg Glu Thr Glu Ile Lys Glu Gly Gly Val Asp 
                245                 250                 255     


Arg Asn Thr Arg Trp Arg Leu Leu Gly Asn Ser Phe Ser Val Pro Val 
            260                 265                 270         


Ile Ser Phe Leu Leu Ser Pro Leu 
        275                 280 


<210>  12
<211>  893
<212>  PRT
<213>  Klebsormidium flaccidum

<400>  12

Met Asp Gln Glu Ala Arg Trp Arg Ala Gly Trp Arg Pro His Glu Glu 
1               5                   10                  15      


Phe Val Asn Ile Pro Leu Arg Thr Asp Trp Leu Ser Glu Leu Arg Arg 
            20                  25                  30          


Gln His Pro Trp Lys Gly Asp Gly Leu Val Val Val Ser Met Phe Asp 
        35                  40                  45              


Gly Met Gly Gly Cys Trp Gln Ala Leu Lys Ala Leu Gly Ile Pro Val 
    50                  55                  60                  


Lys Lys Gly Tyr Ser Cys Glu Ile Lys Glu Phe Ala Asn Ala Val Val 
65                  70                  75                  80  


Lys Glu Arg Phe Pro Asp Val Ile His Leu Gly Ser Val Thr Ala Val 
                85                  90                  95      


Thr Gln Asp Met Ile Pro Glu Pro Val Asp Leu Ile Val Ala Gly Phe 
            100                 105                 110         


Pro Cys Gln Asp Leu Ser Ser Met Gly Asn Gln Arg Gly Leu His Gly 
        115                 120                 125             


Ala Arg Ser Gly Leu Phe Phe His Ile Pro Arg Phe Ile Ser Met Phe 
    130                 135                 140                 


Lys Ala Lys Trp Phe Leu Val Glu Asn Val Lys Cys Arg Trp Gln Asp 
145                 150                 155                 160 


Gln Ala Glu Ile Thr Lys Tyr Leu Leu Asn Val Leu Pro Leu Glu Leu 
                165                 170                 175     


Asp Ala Glu Glu Leu Ser Pro Gln Ser Arg Val Arg Asn Tyr Trp Thr 
            180                 185                 190         


Asn Leu Pro Leu Pro Pro Asn Leu Pro Gly Ile Arg Asp Ala Pro Glu 
        195                 200                 205             


Thr Ser Val Gln His Phe Leu Glu Asn Ala Ile Ala Pro Phe Val Lys 
    210                 215                 220                 


Thr Gly Thr Val Met Thr Thr Asn Asn Asp Ala Asn Thr Ser Asn Cys 
225                 230                 235                 240 


Ala Leu Lys Ser Ile Tyr Asp Leu Ala Ser Gly Gly Ala Arg Tyr Leu 
                245                 250                 255     


Glu Val Glu Glu Ile Glu Ala Met Met Gly Tyr Ser Ala Gly Tyr Ser 
            260                 265                 270         


Lys Ile Pro Tyr Asn Lys His Gly Cys Ile Leu Pro Phe Ser Ser Ser 
        275                 280                 285             


Lys Lys Gln Ser Gly Arg Arg Arg Cys Ser Gln Gly Gly Ala Ser Glu 
    290                 295                 300                 


Gly Ala Asn Gly Gly Gly Ala Glu Gly Pro Pro Gln Lys Arg Leu Lys 
305                 310                 315                 320 


Phe Glu Glu Gly Gly Ala Ser Gly Thr Glu Ala Gly Ala Glu Lys Glu 
                325                 330                 335     


Ala Glu Cys Asp Gly Ala Gln Val Gly Lys Glu Glu Pro Thr Gly Asp 
            340                 345                 350         


Glu Leu Gly Lys Gly Ile Ile Ala Leu Ser Ser Asp Glu Asp Asp Val 
        355                 360                 365             


Val Phe Gln Gly Glu Ala Ala Ala Val Glu Glu Gly Glu Asp Leu Pro 
    370                 375                 380                 


Gly Gly His Ser Ala Glu Gly Asp Val Gly Ala Asn Glu Pro Pro Gly 
385                 390                 395                 400 


Lys Ser Ala Leu Pro Leu Thr Trp Leu Gly Met Gly Ala Gln Gly Gly 
                405                 410                 415     


Pro Asp Glu Ala Gly Ser Ser Gly Leu Ser Asn Glu Glu Lys Ser Val 
            420                 425                 430         


Gly Gly Gly Glu Lys Ser Pro Gly Tyr Gly Leu Arg Ala Arg Lys Pro 
        435                 440                 445             


Val Asn Tyr Ala Ala Glu His Val Glu Ile Asp Asp Val Ser Pro Gly 
    450                 455                 460                 


Arg Arg Pro Thr Pro Lys Arg Arg Ser Gln Ser Thr Pro Arg Arg Lys 
465                 470                 475                 480 


Leu Leu Ser Pro Gly Ser Ser Gly Glu Ala Leu Phe Ala Thr Lys Asp 
                485                 490                 495     


Leu Arg Trp Glu Leu Leu Gly Asn Ser Phe Val Val Pro Cys Ile Ala 
            500                 505                 510         


Tyr Met Leu Ser Gln Leu Leu Ser Pro Gln Leu Arg Ala Arg Ala Gln 
        515                 520                 525             


Arg Ile Met Ala Ile Pro Thr Pro Asp Val Lys Asp Ala Cys Leu Phe 
    530                 535                 540                 


Lys Glu Gly Glu Val Trp Ala Leu Tyr Asn Glu Asp Met Ala Pro Asn 
545                 550                 555                 560 


Trp Tyr Ala Cys Val Thr His Val Asp Val Thr Gln Pro Asp Trp Asp 
                565                 570                 575     


Gly Arg Lys Lys Leu Pro Thr Gln Phe Gly Val His Tyr Arg Phe Tyr 
            580                 585                 590         


Glu Tyr Leu Pro Ser Ser Glu Asn Pro Lys Ser Pro Ile Gln Gly Val 
        595                 600                 605             


Gly Ile Leu Lys Leu Ala Cys Glu Asp Tyr Thr Ser Val Asp Lys Ala 
    610                 615                 620                 


Phe Ser His Arg Val Asn Pro Ala His Leu Glu Gly Gly Arg Ile Leu 
625                 630                 635                 640 


Val Tyr Pro Arg Gly Gly Glu Val Trp Val Val Lys Asp Arg Leu Arg 
                645                 650                 655     


Lys Phe Gly Arg Phe Lys Leu His Val Tyr Ile Val Lys Ser Thr Ala 
            660                 665                 670         


Asp Pro Leu Thr Gly Gln Phe Glu Cys Thr Ile Arg Ile Leu Val Ser 
        675                 680                 685             


Gln Pro Arg Ser Thr Ser Lys Thr Pro Ile Tyr Arg Met Ala Gly Gly 
    690                 695                 700                 


Glu Arg Val Leu Ser Gly Gly Arg Thr Val Phe Ser Tyr Gln Val Pro 
705                 710                 715                 720 


Tyr Phe Phe Lys Asn Glu Ala Gly Leu Phe Tyr Val Glu Pro Gln Tyr 
                725                 730                 735     


Asp Gln Thr Val Ala Met Arg Arg Arg Arg Leu Leu Glu Trp Asp Asp 
            740                 745                 750         


Asp Glu Asp Asp Val Ala Ala Glu Glu Glu Glu Leu Gly Arg Gly Glu 
        755                 760                 765             


Glu Val Leu Glu Pro Glu Ala Glu Tyr Pro Ala Ser Phe Pro Glu Thr 
    770                 775                 780                 


Glu Ser Ala Gln Lys Leu Pro Thr Leu Ala Glu Tyr Ala Pro Thr Ser 
785                 790                 795                 800 


Gln Ala Leu Gln Leu Val Ala Pro Asp Ala Lys Leu Pro Gln Leu Asn 
                805                 810                 815     


Ala Leu Glu Asp Gln Asn Gly Gly Pro Ala Gln Ser Ser Ala Gln Ala 
            820                 825                 830         


Pro Ala Ile Glu Gln Ala Leu Ala Ser Arg Lys Gly Lys Glu Lys Ile 
        835                 840                 845             


Asp Val Ser Asp Ser Lys Ala Gln Ala Asp Asp Val Ala Gly Val Leu 
    850                 855                 860                 


Pro Ser Glu Gly Arg Gly Leu Leu Glu Glu Arg Thr Val Leu Lys Cys 
865                 870                 875                 880 


Arg Asp Ile His Val Leu Met Asp Leu Leu Pro Arg Leu 
                885                 890             


<210>  13
<211>  630
<212>  PRT
<213>  Selaginella moellendorffii

<400>  13

Met Glu Glu Leu Leu Ala Lys Ile Arg Glu Ala Glu Ala Leu Ala Leu 
1               5                   10                  15      


Arg Leu Lys Glu Ser Glu Leu Lys Lys Lys Ile Lys Lys Pro Pro Pro 
            20                  25                  30          


Pro Thr Thr Lys Glu Lys Glu Glu Phe Pro Glu His Gly Asp Trp Leu 
        35                  40                  45              


Asp Ala Phe Arg Arg Asn Leu Gly Ala Leu Asp Arg Arg Leu Val Val 
    50                  55                  60                  


Leu Ser Leu Phe Asp Gly Ile Gly Gly Thr Trp Ala Ala Leu Asp Arg 
65                  70                  75                  80  


Leu Glu Val Arg Tyr Lys Gly Tyr Ser Ser Glu Ile Asn Pro Tyr Ala 
                85                  90                  95      


Ala Arg Val Leu Lys Ala Lys Phe Pro Asn Val Thr His Leu Gly Asp 
            100                 105                 110         


Val Lys Asp Ile Arg Arg Gly Asp Ile Glu Glu Glu Ile Asp Leu Val 
        115                 120                 125             


Val Gly Gly Phe Pro Cys Gln Asp Leu Thr Ser Met Gly Lys Arg Asp 
    130                 135                 140                 


Gly Phe Leu Val Glu Asn Val Ala Ser Met Thr Trp Ile Asp Arg Glu 
145                 150                 155                 160 


Glu Ile Ser Lys Tyr Leu Asn Cys Leu Pro Ile Glu Ile Asp Ser Gln 
                165                 170                 175     


Asp Leu Thr Ala Ser Lys Arg Lys Arg Leu Tyr Trp Thr Asn Ile Pro 
            180                 185                 190         


His Pro Glu Lys Leu Pro Asp Val Arg Asn His Ala Ser Asn Leu Leu 
        195                 200                 205             


Gln His Ala Leu Asp Asp Ala Thr Ala Leu Glu Glu Lys Ile Gly Cys 
    210                 215                 220                 


Val Met Thr Cys Asn Tyr Tyr Val Gly Gly Phe Gly Gln Leu Gln Arg 
225                 230                 235                 240 


Val Phe Asp Arg Lys Asp Lys Val Leu Arg Tyr Val Thr Val Thr Glu 
                245                 250                 255     


Leu Glu Lys Val Thr Val Ile Ser Tyr Met Leu Ser Pro Leu Met Leu 
            260                 265                 270         


Pro Ser Thr Trp Glu Ala His Val Ile Tyr Asn Phe Ser Pro Lys Phe 
        275                 280                 285             


Arg Glu Ser Glu Cys Ala Val Leu Glu Thr Gly Glu Leu Trp Ala Leu 
    290                 295                 300                 


Tyr Asn Thr Arg Ser Gln Pro Ser Trp Tyr Ala Val Ile Leu Ser Arg 
305                 310                 315                 320 


Ser Gly Asp Arg Phe Asp Thr Leu Gln Ser Lys Lys Lys Lys Lys Gly 
                325                 330                 335     


Leu Gln Ile His Val Cys Phe Leu Glu Leu Asp Thr Gly Phe Leu Ala 
            340                 345                 350         


Ala Asn Asp Asp Gln Trp Ser Pro Leu Arg Gly Thr Gly Gln Tyr Asn 
        355                 360                 365             


Arg Ile Asp Lys Ala Asp Leu Gln Thr Ser Trp Val Thr Phe Ser His 
    370                 375                 380                 


Arg Met Thr Thr Phe Lys Lys Leu Gly Asp Ser Tyr Phe Ile Tyr Pro 
385                 390                 395                 400 


Gly Glu Asn Glu Val Trp Ala Val Phe Asp Arg Asp Ser Ser Arg Pro 
                405                 410                 415     


Thr Leu Tyr Tyr Val Leu Val Leu Thr Thr Glu Ile Asp Trp Asn Leu 
            420                 425                 430         


Val Thr Arg Thr Pro Ser Gly Val Glu Gly Phe Ala Ser Arg Cys Arg 
        435                 440                 445             


Leu Leu Gln Gln Thr Ser Ala Ser Asp Ile Phe Arg Leu Thr Asp Thr 
    450                 455                 460                 


Glu Val Ala Phe Lys Asp Leu Ala Gln Phe Cys Phe Lys Val Pro Tyr 
465                 470                 475                 480 


Tyr Phe Lys Gly Glu Gly Ser Val Phe Lys Leu Glu Leu Ser Lys Thr 
                485                 490                 495     


Gly Lys Tyr Leu Asn His Lys Val Gly Arg Lys Arg Arg Arg Lys Lys 
            500                 505                 510         


Gly Gly Ser Asp Gly Glu Glu Glu Asp Glu Ser Glu Ser Asp Glu Met 
        515                 520                 525             


Glu Glu Gln Glu Gln Gly Ser Phe Thr Pro Leu Leu Asp Arg Val Leu 
    530                 535                 540                 


Val Glu Lys Leu Val Pro Pro Ala Lys Ser Val Gly Gly Val Leu Leu 
545                 550                 555                 560 


Pro Glu Thr Gln Lys His Ile Asn Gly Gly Thr Val Val Ala Val Gly 
                565                 570                 575     


Gln Gly Val Tyr Asn Ser Asp Gly Glu Ile Val Pro Asn Leu Cys Lys 
            580                 585                 590         


Val Gly Asp Lys Val Leu Leu Pro Asp Trp Gly Gly Val Glu Ile Lys 
        595                 600                 605             


Leu Glu Asp Lys Ser Tyr Glu Val Phe Arg Asp Lys Ser Ile Leu Ala 
    610                 615                 620                 


Ile Met Ser Asp Phe Glu 
625                 630 


<210>  14
<211>  685
<212>  PRT
<213>  Selaginella moellendorffii

<400>  14

Met Glu Glu Leu Val Ala Lys Ile Arg Glu Ala Glu Ala Leu Ala Leu 
1               5                   10                  15      


Arg Leu Lys Glu Arg Glu Leu Lys Lys Glu Ile Lys Lys Pro Pro Pro 
            20                  25                  30          


Pro Thr Ser Lys Lys Lys Glu Glu Phe Pro Glu His Gly Asp Trp Leu 
        35                  40                  45              


Asp Ala Phe Arg Arg Asn Leu Gly Ala Leu Asp Arg Arg Leu Val Val 
    50                  55                  60                  


Leu Ser Leu Phe Asp Gly Ile Gly Gly Thr Trp Ala Ala Leu Asp Arg 
65                  70                  75                  80  


Leu Glu Val Arg Tyr Lys Gly Tyr Ser Ser Glu Ile Asn Pro Tyr Ala 
                85                  90                  95      


Ala Arg Val Leu Lys Ala Lys Phe Pro Asn Val Thr His Leu Gly Asp 
            100                 105                 110         


Val Lys Asp Ile Arg Arg Gly Asp Ile Glu Glu Glu Ile Asp Leu Val 
        115                 120                 125             


Val Gly Gly Phe Pro Cys Gln Asp Leu Thr Ser Met Gly Lys Arg Asp 
    130                 135                 140                 


Gly Phe Leu Val Glu Asn Val Ala Ser Met Thr Trp Ile Asp Arg Glu 
145                 150                 155                 160 


Glu Ile Ser Lys Tyr Leu Asn Cys Leu Pro Ile Glu Ile Asp Ser Gln 
                165                 170                 175     


Asp Leu Thr Ala Ser Lys Arg Lys Arg Leu Tyr Trp Thr Asn Ile Pro 
            180                 185                 190         


His Pro Glu Lys Leu Pro Asp Val Arg Asn His Ala Ser Asn Leu Leu 
        195                 200                 205             


Gln His Ala Leu Asp Asp Ala Thr Ala Leu Glu Glu Lys Ile Gly Cys 
    210                 215                 220                 


Val Met Thr Cys Asn Tyr Tyr Val Gly Gly Phe Gly Gln Leu Gln Arg 
225                 230                 235                 240 


Val Phe Asp Arg Lys Asp Glu Val Leu Arg Tyr Val Thr Val Thr Glu 
                245                 250                 255     


Leu Glu Lys Val Met Gly Phe Pro Ala Gly His Thr Asp Ile Asp Phe 
            260                 265                 270         


Gly Asn Leu Asp Asp Phe Val Pro Phe Ala Ser Glu Gln Thr Pro Lys 
        275                 280                 285             


Arg Lys Cys Lys Leu Asp Asp Lys Ala Lys Thr Ile Arg Trp Asn Leu 
    290                 295                 300                 


Ile Gly Asn Ser Phe Ser Val Ser Val Ile Ser Tyr Met Leu Ser Pro 
305                 310                 315                 320 


Leu Met Leu Pro Ser Thr Trp Glu Ala His Val Ile Tyr Asn Phe Ser 
                325                 330                 335     


Pro Lys Phe Arg Glu Ser Glu Cys Ala Val Leu Glu Thr Gly Glu Leu 
            340                 345                 350         


Trp Ala Leu Tyr Asn Thr Arg Ser Gln Pro Ser Trp Tyr Ala Val Ile 
        355                 360                 365             


Leu Ser Arg Ser Gly Asp Arg Phe Asp Thr Leu Gln Ser Lys Lys Lys 
    370                 375                 380                 


Lys Lys Gly Leu Gln Ile His Val Cys Phe Leu Glu Leu Asp Thr Gly 
385                 390                 395                 400 


Phe Leu Ala Ala Asn Asp Asp Gln Trp Ser Pro Ile Arg Gly Thr Gly 
                405                 410                 415     


Gln Tyr Asn Arg Ile Asp Lys Ala Asp Leu Gln Thr Ser Trp Val Thr 
            420                 425                 430         


Phe Ser His Arg Met Thr Thr Phe Lys Lys Leu Gly Asp Ser Tyr Phe 
        435                 440                 445             


Ile Tyr Pro Gly Glu Asn Glu Val Trp Ala Val Phe Asp Arg Asp Ser 
    450                 455                 460                 


Ser Arg Pro Thr Leu Tyr Tyr Val Leu Val Leu Thr Thr Glu Ile Asp 
465                 470                 475                 480 


Trp Asn Leu Val Thr Arg Thr Pro Ser Gly Val Glu Gly Phe Ala Ser 
                485                 490                 495     


Arg Cys Arg Leu Leu Gln Gln Thr Ser Ala Ser Asp Ile Phe Ser Phe 
            500                 505                 510         


Ala Arg Arg Leu Thr Gly Thr Glu Val Ala Phe Lys Asp Leu Ala Gln 
        515                 520                 525             


Phe Cys Phe Lys Val Pro Tyr Tyr Phe Lys Gly Glu Gly Ser Val Phe 
    530                 535                 540                 


Lys Leu Glu Leu Ser Lys Thr Gly Lys Tyr Leu Asn His Lys Val Gly 
545                 550                 555                 560 


Arg Lys Arg Arg Arg Lys Lys Gly Gly Ser Asp Glu Glu Glu Glu Asp 
                565                 570                 575     


Glu Ser Glu Ser Asp Glu Met Glu Glu Gln Glu Gln Gly Ser Phe Thr 
            580                 585                 590         


Pro Leu Leu Asp Arg Val Leu Val Glu Lys Leu Val Pro Pro Ala Lys 
        595                 600                 605             


Ser Val Gly Gly Val Leu Leu Pro Glu Thr Gln Lys His Ile Asn Ala 
    610                 615                 620                 


Gly Thr Val Val Ala Val Gly Gln Gly Val Tyr Asn Thr Asp Gly Glu 
625                 630                 635                 640 


Ile Val Pro Asn Leu Cys Lys Val Gly Asp Lys Val Leu Leu Pro Asp 
                645                 650                 655     


Trp Gly Gly Val Glu Ile Lys Leu Glu Asp Lys Ser Tyr Glu Val Phe 
            660                 665                 670         


Arg Asp Lys Ser Ile Leu Ala Ile Met Ser Asp Phe Glu 
        675                 680                 685 


<210>  15
<211>  736
<212>  PRT
<213>  Sphagnum fallax

<400>  15

Met Asp Thr Phe Leu Ala Lys Ile Glu Glu Leu Lys Arg Glu Ala Glu 
1               5                   10                  15      


Arg Leu Lys His Thr Cys Arg Cys Val Ser Thr Thr Pro Thr Gly Ile 
            20                  25                  30          


Asn Lys Lys Thr Lys Arg Asn Ile Ile Ser Tyr Asn Asn Asp Asn Asn 
        35                  40                  45              


Gly Ile Ile Ala Ser Pro Gly Gly Leu Phe Ser Asn Gly Ile Thr Ser 
    50                  55                  60                  


Ser Pro Cys Asn Ile Pro Gly Tyr Lys Leu Asp Phe Glu Gly Pro Gly 
65                  70                  75                  80  


Gly Asp Gly Asp Trp Val Thr Ala Phe Lys Ala Asp Ala Gly Pro Trp 
                85                  90                  95      


Ser Gly Glu Arg Leu Val Val Leu Ser Leu Phe Asp Gly Leu Gly Gly 
            100                 105                 110         


Ile Trp Gln Ala Leu Thr Asn Leu Gly Ile Pro Phe Ser Gly Tyr Ser 
        115                 120                 125             


Ser Glu Val Leu Ala Pro Ala Ile Gln Val Val Lys Ser Arg His Pro 
    130                 135                 140                 


His Val Lys His Val Gly Asp Val Arg Lys Leu Asn Leu Ser Ala Ile 
145                 150                 155                 160 


Pro Glu Lys Val Asp Leu Val Val Gly Gly Phe Pro Cys Gln Asp Leu 
                165                 170                 175     


Ser Ile Met Gly Lys Lys Glu Gly Leu His Gly Ser Arg Ser Lys Leu 
            180                 185                 190         


Phe Phe Asp Leu Leu Arg Val Leu Gln Ile Phe Lys Pro Lys Trp Phe 
        195                 200                 205             


Leu Val Glu Asn Val Ala Ser Met Ser Trp Val Asp Arg Glu Glu Ile 
    210                 215                 220                 


Thr Arg His Leu Lys Val Val Pro Met Glu Leu Asp Ser Gln Glu Ile 
225                 230                 235                 240 


Thr Ala Ser Lys Arg Arg Arg Leu Tyr Trp Thr Asn Ile Pro His Pro 
                245                 250                 255     


Pro Arg Leu Pro Arg Leu Arg Asp His Pro Ser Thr Ser Leu Gln Ser 
            260                 265                 270         


Cys Leu Glu Gly Ala Leu Ala Leu Glu Gln Lys Cys Gly Val Val Leu 
        275                 280                 285             


Cys Asn Asn Leu Tyr Lys Gly Gly Gly Ala Arg Leu Glu Leu Val Leu 
    290                 295                 300                 


Asp Asn Thr Ile Asn Lys Leu Arg Tyr Ile Lys Gln Thr Glu Ile Glu 
305                 310                 315                 320 


Leu Leu Met Gly Tyr Pro Arg Asn Tyr Thr Asn Val Val Val Arg Arg 
                325                 330                 335     


Thr Lys Ile Thr Glu Lys Ile Ile Lys Ala Val Arg Ile Pro Glu Lys 
            340                 345                 350         


Pro Thr Val Ala Leu Pro Lys Ser Ser Pro Pro Gln Thr Pro Ser Ile 
        355                 360                 365             


Arg Gln Leu Arg Lys Asn Arg Thr Ser Arg Thr Phe Phe Ala Pro Gln 
    370                 375                 380                 


Val Trp Glu Arg Asn Pro Thr Arg Gln Glu Ser Leu Lys Asp Leu Asp 
385                 390                 395                 400 


Arg Trp Phe Leu Leu Gly Asn Ser Phe Ser Val Gln Val Ile Thr Tyr 
                405                 410                 415     


Leu Thr Ser Ser Leu Leu Lys Ser Glu Val Arg Phe His Gly Lys Ala 
            420                 425                 430         


Val Asn Ile Val Gly Ser Val Arg Glu Glu Glu Leu Ser Ala Met Glu 
        435                 440                 445             


Pro Gly Asp Val Trp Ala Leu Phe Asn Glu His Gly Arg Pro Asn Trp 
    450                 455                 460                 


Tyr Ala Val Ile Gln Ser Arg Thr Gly Asp Arg Phe Ser Glu Ile Pro 
465                 470                 475                 480 


Asp Ala Thr Gly Lys Arg Ser Ile Thr Lys Leu Pro Leu Ser Ile Glu 
                485                 490                 495     


Met Lys Tyr Leu Glu Met Thr Pro Ala Tyr Ala Lys Asp Glu Val Asp 
            500                 505                 510         


Glu Trp Asn Pro Gln Arg Gly Ser Gly Leu Leu Lys Leu Arg Asp Val 
        515                 520                 525             


Val Asp Ile Gln Asp Asn Trp Gln Ala Phe Ser His Arg Val Thr Ser 
    530                 535                 540                 


Tyr Val Lys Phe Glu Asn Ser Tyr Phe Val Tyr Pro Gly Asn Asp Glu 
545                 550                 555                 560 


Val Trp Ala Val Tyr His Ala Glu Thr Leu Ser Arg Tyr Phe Val Tyr 
                565                 570                 575     


Val Val Glu Ser Thr Ile Ile Cys Ala Arg Leu Leu Asn Asp Lys Pro 
            580                 585                 590         


Gly Gln Asp Glu Gly Phe Leu Ala Arg Cys Leu Leu Leu Gln Lys Thr 
        595                 600                 605             


Thr Glu His Glu Val Tyr Leu Lys Thr Ser Lys Glu Val Glu Leu Ser 
    610                 615                 620                 


Asp Ile Gln Pro Phe Cys Phe Arg Val Pro Phe His Ile Lys Asn Glu 
625                 630                 635                 640 


Ala Asn Leu Leu Lys Val Glu Val Ser Gly Val Lys Ser Arg Gln Ser 
                645                 650                 655     


Met Lys Ala Asp Arg Glu Thr Thr Ala Gly Tyr Lys Arg Arg Lys Gln 
            660                 665                 670         


Gly Gln Gly Glu Ser Asp Asp Asp Asp Asp Leu Asp Asp Val Asp Asn 
        675                 680                 685             


Asn Ser Pro Glu Asp Val Asn Ala Asp Gly Thr Thr Ala Glu Glu Met 
    690                 695                 700                 


Leu Ala Glu Asp Glu Ala Ile Glu Val Met Asn Gly Gly Leu Glu Val 
705                 710                 715                 720 


Val Val Ala Leu Pro Asp Asp Ile Gly Asp Thr Asn Gly Gly Thr His 
                725                 730                 735     


<210>  16
<211>  711
<212>  PRT
<213>  Sphagnum fallax

<400>  16

Met Asp Gly Leu Leu Glu Lys Ile Val Glu Leu Ala Lys Asp Ala Glu 
1               5                   10                  15      


His Leu Lys Arg Thr Cys Arg Cys Glu His Gly Thr Pro Thr Arg Ser 
            20                  25                  30          


Asn Lys Lys Ala Lys Arg Asn Gly His Asn Gly Thr Pro Ala Ser Pro 
        35                  40                  45              


Glu Arg Gln Ser Thr Asp Ile Ile Ala Ser Ser Pro Phe Asn Phe Arg 
    50                  55                  60                  


Gly His Lys Leu Asp Phe Glu Gly Pro Gly Gly Asp Gly Asp Trp Val 
65                  70                  75                  80  


Ser Ala Phe Lys Ala Glu Ala Gly Pro Trp Ser Gly Glu Arg Leu Val 
                85                  90                  95      


Val Leu Ser Leu Phe Asp Gly Leu Gly Gly Ile Trp Gln Ala Leu Thr 
            100                 105                 110         


Lys Leu Gly Ile Pro Phe Ser Gly Tyr Ser Ser Glu Val Leu Ala Pro 
        115                 120                 125             


Ala Ile Gln Val Val Lys Ser Arg His Pro Arg Val Lys His Val Gly 
    130                 135                 140                 


Asp Ile Arg Lys Leu Asn Leu Ser Ala Val Pro Glu Lys Val Asp Leu 
145                 150                 155                 160 


Val Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Ile Met Gly Lys Lys 
                165                 170                 175     


Glu Gly Leu His Gly Ser Arg Ser Lys Leu Phe Phe Asp Leu Leu Arg 
            180                 185                 190         


Val Leu Lys Val Phe Lys Pro Lys Trp Phe Leu Val Glu Asn Val Ala 
        195                 200                 205             


Ser Met Ser Trp Val Asp Arg Glu Glu Ile Thr Arg His Leu Lys Val 
    210                 215                 220                 


Ala Pro Met Glu Leu Asp Ser Gln Glu Ile Thr Ala Ser Lys Arg Arg 
225                 230                 235                 240 


Arg Leu Tyr Trp Thr Asn Ile Pro His Pro Pro Arg Leu Pro Arg Leu 
                245                 250                 255     


Arg Asp His Pro Ser Thr Ser Leu Gln Ser Cys Leu Glu Gly Ala Leu 
            260                 265                 270         


Ala Leu Glu Gln Lys Cys Gly Val Ile Leu Cys Ser Asn Leu Tyr Lys 
        275                 280                 285             


Gly Ser Thr Ala Arg Leu Glu Leu Val Leu Asp Asn Lys Thr Asn Lys 
    290                 295                 300                 


Leu Arg Tyr Ile Lys Gln Thr Glu Val Glu Val Leu Met Gly Tyr Pro 
305                 310                 315                 320 


Lys Asp Tyr Thr Asn Val Val Ala His Glu Thr Lys Gly Arg Thr Glu 
                325                 330                 335     


Gln Ala Glu Lys Val Leu Lys Thr Pro Val Arg Ala Lys Ser Val Glu 
            340                 345                 350         


Pro Lys Pro Ser Ser Val Thr Pro Pro Ser Ser Arg Gln Leu Arg Lys 
        355                 360                 365             


Asn Arg Lys Ser Gln Thr Phe Phe Val Pro Gln Val Trp Glu Thr Lys 
    370                 375                 380                 


Pro Thr Arg Gln Asp Ser Leu Lys Asp Ile Asp Arg Trp Phe Leu Leu 
385                 390                 395                 400 


Gly Asn Thr Phe Ser Val Gln Val Ile Ala Tyr Leu Thr Ser Pro Leu 
                405                 410                 415     


Leu Arg Ala Glu Val Arg Ser His Gly Lys Arg Val Asn Ile Val Gly 
            420                 425                 430         


Ser Val Lys Glu Glu Glu Leu Ser Ala Met Glu Pro Gly Asp Val Trp 
        435                 440                 445             


Ala Leu Phe Asn Glu Tyr Gly Arg Pro Asn Trp Tyr Ala Val Ile Glu 
    450                 455                 460                 


Ser Arg Thr Gly Asp Arg Phe Ser Ala Phe Pro Asp Ala Thr Gly Lys 
465                 470                 475                 480 


Arg Asn Val Thr Lys Leu Pro Leu Lys Ile Glu Met Lys Tyr Leu Glu 
                485                 490                 495     


Met Thr Pro Ala Tyr Leu Lys Glu Glu Val Asp Glu Trp Asn Pro Gln 
            500                 505                 510         


Arg Gly Ser Gly Leu Leu Lys Leu Arg Asn Val Met Asp Ile Gln Asp 
        515                 520                 525             


Asn Trp Gln Ala Phe Ser His Arg Val Thr Ser Tyr Val Lys Leu Glu 
    530                 535                 540                 


Asp Ser Tyr Phe Val Tyr Pro Gly Asn Asp Glu Val Trp Ala Val Tyr 
545                 550                 555                 560 


Asn Gly Glu Thr Leu Ser Arg Tyr Phe Val Tyr Val Ser Glu Ser Thr 
                565                 570                 575     


Ile Ser Ser Asp Arg Leu Arg Arg Gly Lys Pro Gly Gln Glu Gly Phe 
            580                 585                 590         


His Ala Arg Cys Leu Leu Leu Gln Lys Thr Ala Glu His Glu Ile Phe 
        595                 600                 605             


Leu Lys Thr Ser Thr Met Val Glu Phe Thr Asp Leu Gln Pro Phe Cys 
    610                 615                 620                 


Phe Arg Val Pro Phe Tyr Ile Lys His Glu Ala Asn Leu Leu Lys Val 
625                 630                 635                 640 


Glu Val Ser Gly Val Lys Ser Arg Gln Ser Met Arg Ala Asp Lys Asp 
                645                 650                 655     


Ser Thr Ala Gly Tyr Glu Arg Arg Gly Lys Lys Asp Leu Gly Gly Pro 
            660                 665                 670         


Asp Asp Asp Glu Asp Gly Asp Leu Ile Gly Gly Asp Leu Asp Phe Pro 
        675                 680                 685             


Glu Asp Asn Asp Ala Asp Arg Ile Gly Ala Ala Thr Gly Thr Pro Gly 
    690                 695                 700                 


Ser Ile Glu Met Met Ser Gly 
705                 710     


<210>  17
<211>  739
<212>  PRT
<213>  Sphagnum fallax

<400>  17

Met Glu Asn Leu Phe Lys Lys Ile Gln Glu Leu Gln Asp Glu Ala Cys 
1               5                   10                  15      


Arg Leu Lys Glu Glu Glu Lys Glu Arg Gln Lys Gly Tyr Ser Ala Ser 
            20                  25                  30          


Ser Pro Gln Pro Ser Ser Thr Trp Asn Phe Thr Thr Asp Arg Gln Gln 
        35                  40                  45              


His Ser Ser Arg Thr Leu Pro Pro Cys Ala Ser Arg Arg Phe Asn Asn 
    50                  55                  60                  


Leu Val Gln Gln Ser Ser Gln Ser Pro Leu Pro Tyr Pro Pro Cys Thr 
65                  70                  75                  80  


Thr Asp Ile Lys Glu Pro Phe Glu Gly Val Val Gly Asp Gly Glu Trp 
                85                  90                  95      


Leu Arg Ala Phe Arg Lys Asp Ala Gly Pro Trp Asn Gly Glu Lys Leu 
            100                 105                 110         


Val Val Leu Ser Leu Phe Asp Gly Ile Gly Gly Ile Trp Ala Ala Leu 
        115                 120                 125             


Thr Arg Leu Gly Ile Pro Phe Thr Gly Tyr Ser Ser Glu Val Ser Ile 
    130                 135                 140                 


Pro Ala Leu Glu Val Leu Lys Ala Lys Tyr Pro Glu Val His His Val 
145                 150                 155                 160 


Gly Asp Val Arg Lys Val Glu Arg Met Thr Val Ser Glu Lys Val Asp 
                165                 170                 175     


Leu Val Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Cys Met Gly Lys 
            180                 185                 190         


Arg Glu Gly Leu His Gly Gln Arg Ser Lys Leu Phe Phe Asp Leu Leu 
        195                 200                 205             


His Val Leu Lys Ile Phe Asn Pro Ser Trp Phe Leu Val Glu Asn Val 
    210                 215                 220                 


Ala Ser Met Thr Trp Met Asp Arg Asp Glu Ile Ser Lys Tyr Leu Lys 
225                 230                 235                 240 


Leu Gln Pro Ile Glu Leu Asp Ser Ile Glu Leu Ala Pro Ser Lys Arg 
                245                 250                 255     


Arg Arg Leu Tyr Trp Thr Asn Ile Pro His Pro Ala Arg Leu Pro Arg 
            260                 265                 270         


Val Lys Asn His Pro Ser Thr Phe Val Gln Ser Cys Leu Leu Asp Gly 
        275                 280                 285             


Ile Ala Leu Glu Glu Lys Thr Gly Ile Ile Leu Ser Asn Asn Ser Tyr 
    290                 295                 300                 


Lys Ser Asn Ser Cys Gln Met Glu Leu Val Leu Glu Asn Gly Thr Ser 
305                 310                 315                 320 


Glu Leu Arg Tyr Leu Ser His Val Glu Leu Glu Arg Ile Met Gly Tyr 
                325                 330                 335     


Pro Ser Asn His Thr Ser Leu Cys Ile Asp Glu Ala Glu Asn Asn Ser 
            340                 345                 350         


Asn Pro Met Ile Ser Asn Val Ser Arg Tyr Val Gln Thr Ser Asn Thr 
        355                 360                 365             


Tyr His Lys Lys Arg Gly Lys Ile Cys Gly Val Gly Gly Pro Thr Arg 
    370                 375                 380                 


Phe Cys Thr Pro Pro Ala Ser Thr Leu Gly Glu Pro Leu Lys Asp Ser 
385                 390                 395                 400 


Val Arg Trp Ala Leu Leu Gly Asn Thr Phe Thr Val Pro Val Ile Ala 
                405                 410                 415     


Tyr Leu Val Ser Pro Leu Leu Lys Ser Ser Val Arg Val Leu Ala Gln 
            420                 425                 430         


Pro Val Thr Ile Ser Asp Pro Val Lys Glu Ser Glu Cys Ser Val Met 
        435                 440                 445             


Asp Pro Asp Asp Val Trp Ala Leu Tyr Asn Glu His Glu Arg Pro Asn 
    450                 455                 460                 


Trp Tyr Ala Leu Ile Leu Arg Arg Ser Gly Asp Arg Phe Ser Arg Cys 
465                 470                 475                 480 


Gly Arg Ala Asp Lys Lys Asn Pro Leu Arg Ile Glu Met Gln Tyr Leu 
                485                 490                 495     


Glu Ile Thr Gln Pro Tyr Leu Glu Gly Glu Glu Asp Ser Trp Asn Met 
            500                 505                 510         


Leu Arg Gly Thr Gly Leu Phe Glu Leu Arg Gln Gln Ile Asp Cys Gln 
        515                 520                 525             


Ile Ser Trp Val Thr Phe Ser His Arg Val Thr Ser Val Val Lys Val 
    530                 535                 540                 


Gln Asp Lys Phe Phe Ile Tyr Pro Gly Gln Asp Glu Val Trp Ala Val 
545                 550                 555                 560 


Cys Ser Arg Lys Ala Trp Ser Asn Phe Phe Val Tyr Val Val Glu Ser 
                565                 570                 575     


Ser Val Asp Ile Ser Arg Leu Gln Ser Gly Arg Pro Gly Asn Glu Gly 
            580                 585                 590         


Phe Thr Ala Cys Cys His Leu Leu Ile Lys Thr Thr Glu His Glu Thr 
        595                 600                 605             


Tyr Arg Lys Thr Asn Thr Thr Leu Glu Phe Thr Asp Ile Ser Leu Phe 
    610                 615                 620                 


Cys Phe Arg Ala Pro Tyr Val Phe Lys Gln Gln Ala Asn Met Leu Arg 
625                 630                 635                 640 


Leu Glu Val Gly Ala Lys Gly Arg Lys Val Arg Asn Ile Glu Ser Gly 
                645                 650                 655     


Ile Arg Arg Ser Lys Arg Lys Arg Lys Asp Thr Pro Glu Ala Leu Arg 
            660                 665                 670         


Asp Asp Val Asn Glu Glu Gly Glu Gly Tyr Ile Ala Asn Val Phe Gln 
        675                 680                 685             


Gly Thr Asp Arg Val Glu Gln Lys Gly Arg Ala Ala Thr Thr Asp Ile 
    690                 695                 700                 


Tyr Asp Val Gly Tyr Gly Pro Gln Ile Asn Ala Ser Ile Asp Glu Glu 
705                 710                 715                 720 


Ser Thr Gln Gln His Leu Ala Asp Pro Glu Thr Ile Ile Ile Ser Asp 
                725                 730                 735     


Asp Asp Asp 
            


<210>  18
<211>  767
<212>  PRT
<213>  Sphagnum fallax

<400>  18

Met Asp Ser Ile Ile Lys Lys Leu Gln Glu Leu Glu Arg Glu Ala Arg 
1               5                   10                  15      


Ala Leu Gln Glu Lys Glu Lys Glu Gln Val Tyr Ser Gln Leu Gln Thr 
            20                  25                  30          


Thr Pro Ala Gly Asn Val Asn Asp Arg Gln Glu Val Ser Ser Gly Trp 
        35                  40                  45              


Pro Ser Gly Ser Phe Asn Gln Glu Phe Pro Cys Thr Pro Val Pro Leu 
    50                  55                  60                  


Cys Thr Thr Arg Ser Lys Glu Ala Phe Glu Gly Asp Gly Asp Gly Asp 
65                  70                  75                  80  


Trp Trp Thr Ala Phe Arg Lys Lys Ala Gly Pro Trp Lys Gly Glu Lys 
                85                  90                  95      


Leu Val Val Leu Ser Leu Phe Asp Gly Ile Gly Gly Ile Trp Ala Ala 
            100                 105                 110         


Leu Thr Arg Leu Gly Ile Pro Phe Val Gly Tyr Ser Ser Glu Val Ser 
        115                 120                 125             


Pro Pro Ala Ile Gln Val Val Lys Ala Arg Tyr Pro Asp Val His His 
    130                 135                 140                 


Val Gly Asp Val Arg Lys Leu Asp Arg Thr Ser Phe Ser Gly Asn Val 
145                 150                 155                 160 


Asp Leu Val Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Ala Met Gly 
                165                 170                 175     


Arg Arg Glu Gly Leu His Gly Gln Arg Ser Lys Leu Phe Phe Asp Leu 
            180                 185                 190         


Leu Arg Val Leu Lys Glu Phe Lys Pro Lys Trp Phe Leu Val Glu Asn 
        195                 200                 205             


Val Ala Ser Met Thr Trp Ile Asp Arg Glu Glu Ile Ser Lys Tyr Leu 
    210                 215                 220                 


Arg Val Tyr Pro Ile Glu Leu Asp Ser Ile Glu Leu Thr Pro Thr Arg 
225                 230                 235                 240 


Arg Arg Arg Val Tyr Trp Thr Asn Ile Pro Tyr Pro Pro Arg Leu Pro 
                245                 250                 255     


Arg Val Lys Asp His Pro Ser Thr Phe Val Gln Ser Cys Leu His Asn 
            260                 265                 270         


Ala Ile Ala Leu Glu Glu Lys Thr Gly Val Val Met Gly Phe Gly Ser 
        275                 280                 285             


Asp Lys Ala Asn Ser Cys Leu Leu Glu His Val Met Asp Ile Glu Thr 
    290                 295                 300                 


Arg Lys Met Arg Gly Ile Thr Gln Ile Glu Val Glu Val Met Met Gly 
305                 310                 315                 320 


Tyr Pro Pro Asn His Thr Asn Leu Leu Ile Thr Glu Ala Lys His Gln 
                325                 330                 335     


Thr Asn Ala Leu Val Gln Thr Pro Ser Lys Met Gln Thr Ser Ser Ala 
            340                 345                 350         


Ser Lys Lys Lys Gln Gly Lys Ile Ser Gly Ser Arg Gly Ser Leu Ser 
        355                 360                 365             


Gln Asn Pro Ile Thr Pro Ala Ile Arg Trp Ala Leu Leu Gly Asn Thr 
    370                 375                 380                 


Phe Thr Val Pro Thr Ile Gly Tyr Leu Ile Ser Pro Leu Leu Lys Gly 
385                 390                 395                 400 


Ser Val Arg Val Leu Gly Gln Pro Val Val Ile Pro Gly Pro Thr Lys 
                405                 410                 415     


Glu Asn Glu Cys Ser Val Met Glu Pro Tyr Asp Val Trp Ala Leu Tyr 
            420                 425                 430         


Asn Glu His Glu Arg Pro Asn Trp Tyr Ala Arg Ile Leu Lys Arg Ala 
        435                 440                 445             


Gly Asp Arg Phe Ser Arg Met Ser Tyr Gly Ala Lys Lys His Pro Leu 
    450                 455                 460                 


Tyr Ile Glu Met Gln Tyr Leu Glu Ile Thr Thr Pro Tyr Leu Glu Gly 
465                 470                 475                 480 


Glu Asp Asp Glu Trp Asn Pro Leu Arg Gly Thr Gly Leu Phe Glu Leu 
                485                 490                 495     


Arg Glu Glu Val Asp Thr Gln Val Ala Trp Thr Thr Phe Ser His Arg 
            500                 505                 510         


Val Thr Ser Cys Leu Thr Leu Gly Asp Lys Phe Tyr Val Tyr Pro Gly 
        515                 520                 525             


Lys Asp Glu Val Trp Ala Val Tyr Ser Arg Gln Thr Trp Ser Pro Phe 
    530                 535                 540                 


Phe Val Tyr Val Val Glu Ser Asn Ile Asn Ile Lys Thr Leu Asp Ser 
545                 550                 555                 560 


Ala Lys Pro Gly Leu Glu Gly Phe Tyr Ala Ser Cys Arg Leu Met Leu 
                565                 570                 575     


Arg Thr Ala Glu Leu Gly Val Tyr Arg Lys Thr Glu His Val Leu Glu 
            580                 585                 590         


Phe Thr Asp Leu Ser Leu Phe Cys Phe Arg Ala Pro His Ile Phe Arg 
        595                 600                 605             


Gln Glu Ala Asn Leu Leu Lys Val Glu Val Ser Ala Ser Gly Arg Lys 
    610                 615                 620                 


Thr Lys Asn Ile Glu Arg Gly Ile Arg Arg Ser Lys Glu Ser Gln Glu 
625                 630                 635                 640 


Leu Glu Asp Ala Glu Gly Arg Glu Asp Ile Glu Gly Glu Glu Gln Glu 
                645                 650                 655     


Glu Gln Glu Glu Gln Asn Leu Val Glu Glu Thr Ile Asn Arg Arg Ile 
            660                 665                 670         


Thr Arg Asn Phe Glu Arg Glu Leu Arg Gly Arg Lys Arg Lys Gln Ser 
        675                 680                 685             


Arg Leu Thr Val Phe Gln Asp Asn Glu Val Lys Lys Arg Gly Gly Arg 
    690                 695                 700                 


Glu Asp Gln Glu Gly Tyr Pro Leu Gln Glu Ala Gly Asp Ala Asp Leu 
705                 710                 715                 720 


Gly Lys Lys Ala Pro Lys Cys Lys His Asp Phe Asp Asp Glu Glu Leu 
                725                 730                 735     


Asn Asp Asp Val Asn Arg Asp Ser Gly Gln Glu Asn Gly Ala Ser Thr 
            740                 745                 750         


Pro Glu Thr Val Val Thr Asp Asp Asp Gly Leu Leu His Asp Met 
        755                 760                 765         


<210>  19
<211>  551
<212>  PRT
<213>  Encephalartos barteri

<400>  19

Glu Asp Glu Trp Ile Asp Leu Leu Lys Leu Lys Ser Ala Asp Trp Thr 
1               5                   10                  15      


Gly Lys Pro Leu Val Val Leu Ser Leu Phe Asp Gly Ile Gly Ala Ile 
            20                  25                  30          


Trp Ala Ala Leu Ser Leu Thr Gly Ile Pro Phe Val Gly Tyr Ser Ser 
        35                  40                  45              


Glu Ile Asn Pro Tyr Ala Arg Gln Ile Val Lys Glu Arg Tyr Pro Asp 
    50                  55                  60                  


Val Lys Cys Leu Gly Asp Ile Lys Asn Ile Lys Lys Gly Asp Ile Asn 
65                  70                  75                  80  


Asp Asn Val Asp Phe Ile Val Gly Gly Phe Pro Cys Gln Asp Leu Ser 
                85                  90                  95      


Cys Met Gly Lys Lys Ala Gly Leu His Gly Asp Gln Ser Lys Leu Phe 
            100                 105                 110         


Phe Glu Leu Leu Arg Met Leu Gln Ile Phe Gln Pro Thr Trp Phe Leu 
        115                 120                 125             


Val Glu Asn Val Ala Ser Met Ser Trp Val Asp Arg Asp Glu Ile Ser 
    130                 135                 140                 


Lys Tyr Leu Gly Cys Leu Pro Ile Glu Met Asp Ser Gln Asp Leu Thr 
145                 150                 155                 160 


Pro Thr Arg Arg Arg Arg Leu Phe Trp Thr Asn Ile Pro His Pro Lys 
                165                 170                 175     


Ser Leu Pro Lys Val Arg Asp Asn Leu Ser Thr Ser Leu Gln Ser Val 
            180                 185                 190         


Leu Glu Asn Ala Ile Ala Leu Gln Ala Lys Thr Ala Cys Val Leu Ser 
        195                 200                 205             


Ala Asn His Ser Pro Gly Ser Ala Gly Gln Val Gln Gln Val Leu Asp 
    210                 215                 220                 


Asp Lys Glu Gly Asn Leu Arg Ser Ile Thr Ile Ser Glu Leu Glu Lys 
225                 230                 235                 240 


Ile Met Gly Phe Pro Pro Gly Tyr Thr Asp Phe Gln Phe Ser Phe Thr 
                245                 250                 255     


Ser Glu Thr Gln Ser Pro Lys Pro Ala Lys Thr Trp Ser Pro Asn Ser 
            260                 265                 270         


Pro Gly Lys Ser Glu Lys Pro Ile Lys Leu Ser Asp Pro Asp Gly Ser 
        275                 280                 285             


Ala Ile Thr Thr Glu Lys Val Thr Lys Tyr Asn Ile Arg Trp Arg Leu 
    290                 295                 300                 


Leu Gly Asn Thr Phe Ser Val Lys Val Ile Val Tyr Leu Leu Ser Ser 
305                 310                 315                 320 


Leu Leu Asn Arg Ser Val Arg Glu Arg Lys Val Asn Pro Ile Val Leu 
                325                 330                 335     


Pro Lys Asn Ile Gln Glu Gln Lys Cys Ser Val Met Glu Glu Gly Asp 
            340                 345                 350         


Ile Trp Ala Leu Tyr Asn Thr His Ala Gln Pro Asn Trp Tyr Gly Phe 
        355                 360                 365             


Ile Val Lys Arg Ser Gly Gly Arg Phe Ser Lys Ser Gly Lys Asn Gly 
    370                 375                 380                 


Arg Asn Gly His Ile Arg Ile Glu Val Lys Phe Leu Glu Leu Thr Tyr 
385                 390                 395                 400 


Asp Tyr Thr Ser Gly Glu Ala Asp Lys Trp Ser Pro Asp Arg Gly Ala 
                405                 410                 415     


Gly Lys Tyr Lys Met Asn Arg Asp Ser Asp Ile Gln Asp Asn Trp Pro 
            420                 425                 430         


Ile Phe Ser His Arg Val Arg Ser Tyr Tyr Lys Ser Gln Tyr Cys Tyr 
        435                 440                 445             


Phe Ile Tyr Pro Gly Lys Asp Glu Val Trp Ala Val Tyr Asn Arg Gln 
    450                 455                 460                 


Lys Thr Lys Ser Ser Pro Phe Phe Val Tyr Val Ile Glu Ser Ser Ile 
465                 470                 475                 480 


Asn Ala His Lys Trp Glu Ser Val Lys Pro Gly Lys Glu Gly Phe Lys 
                485                 490                 495     


Ala Arg Cys Tyr Val Met Gln Gln Thr Ser Gln Pro Glu Leu Phe Arg 
            500                 505                 510         


Leu Thr Glu Lys Thr Leu Glu Tyr Glu Asp Leu Ser Cys Phe Ser Phe 
        515                 520                 525             


Ser Val Pro Tyr His Phe Lys Asp Glu Phe Gly Val Leu Lys Ile Glu 
    530                 535                 540                 


Tyr Ser Asn Asn Asn Gln Arg 
545                 550     


<210>  20
<211>  562
<212>  PRT
<213>  Welwitschia mirabilis

<400>  20

Glu Trp Ile Asp Leu Leu Arg Leu Gln Ser Gln Glu Trp Glu Glu Lys 
1               5                   10                  15      


Pro Leu Val Val Leu Ser Leu Phe Asp Gly Ile Gly Ala Ile Trp Glu 
            20                  25                  30          


Ala Leu Thr Ile Leu Gly Ile Pro Phe Val Gly Tyr Ser Ser Glu Ile 
        35                  40                  45              


Asp Pro Cys Ala Ile Gln Val Val Lys Glu Arg Tyr Pro Lys Val Lys 
    50                  55                  60                  


His Val Gly Asp Val Lys Asn Leu Lys Thr Glu Asp Ile Lys Glu Lys 
65                  70                  75                  80  


Val Asp Leu Leu Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Ser Met 
                85                  90                  95      


Gly Arg Lys Val Gly Leu His Gly Glu Arg Ser Lys Leu Phe Phe Asp 
            100                 105                 110         


Leu Leu Gln Ala Met Gln Met Phe Glu Pro Tyr Trp Phe Leu Val Glu 
        115                 120                 125             


Asn Val Ala Ser Met Ser Trp Val Asp Arg Asp Glu Ile Cys Lys Tyr 
    130                 135                 140                 


Ile Ala Cys Leu Pro Ile Glu Leu Asp Ser Gln Asp Leu Thr Pro Gly 
145                 150                 155                 160 


Lys Arg Arg Arg Leu Tyr Trp Thr Asn Ile Pro Phe Pro Glu Thr Leu 
                165                 170                 175     


Pro Asn Val Arg Asp Asn Ser Ser Thr Ser Leu Gln Ser Val Leu Glu 
            180                 185                 190         


Asn Ala Thr Ala Leu Gln Thr Lys Thr Lys Cys Ile Met Ser Ser Ser 
        195                 200                 205             


Ser Lys Ile Gly Lys Met Gly Ser Phe Gln Gln Val Leu Asn Asn Asn 
    210                 215                 220                 


Asp Gly Thr Leu Arg Asp Val Ser Val Thr Glu Leu Glu Lys Ile Met 
225                 230                 235                 240 


Gly Phe Pro Thr Gly His Thr Lys Phe Asp Leu Gln Ala Val Gln Ser 
                245                 250                 255     


Ser Arg Ser Pro Lys Ser Ser Asn Leu Arg Gly Pro Asn Ser Asn Gly 
            260                 265                 270         


Lys Ala Ile Leu Gln Ser Thr Glu Ile Asp Asn Ile Arg Trp Arg Met 
        275                 280                 285             


Leu Gly Asn Ser Phe Ser Val Lys Thr Val Ala Tyr Leu Leu Ser Ser 
    290                 295                 300                 


Leu Ile Asn Lys Ser Val Arg Asp Asn Lys Val Glu His Lys Leu Pro 
305                 310                 315                 320 


Tyr Arg Asn Ile Gln Ala Glu Glu Cys Ser Val Met Asp Pro Gly Glu 
                325                 330                 335     


Leu Trp Val Leu Tyr Asn Gly Arg Gly Leu Pro Asn Trp Tyr Gly Ile 
            340                 345                 350         


Ile Val Asn Arg Ser Gly Gly Arg Phe Thr Met Lys Ser His Lys Asn 
        355                 360                 365             


Gly Asn Thr His Val Gln Val Glu Val Arg Phe Leu Glu Leu Ser Tyr 
    370                 375                 380                 


Glu Tyr Gly Gly Lys Asp Glu Asp Glu Gln Cys Pro Glu Arg Gly Thr 
385                 390                 395                 400 


Gly Arg Tyr Lys Ile Cys Arg Asp Thr Glu His Gln Asn Ser Trp Phe 
                405                 410                 415     


Ala Phe Ser His Arg Met Lys Ser Tyr Trp Lys Asn Lys His Ala Tyr 
            420                 425                 430         


Phe Ile Tyr Pro Gly Lys Gly Glu Val Trp Ala Ile Asn His Arg Trp 
        435                 440                 445             


Arg Ala Lys Thr Cys Pro Phe Phe Val Tyr Val Ala Asp Ser Glu Phe 
    450                 455                 460                 


Ser Ile Pro Gln Asn Lys Leu Gly Ser Thr Lys Pro Gly Lys Glu Lys 
465                 470                 475                 480 


Phe Lys Ala Lys Cys Tyr Ala Leu Gln Gln Thr Leu Asp Ala Glu Val 
                485                 490                 495     


Tyr Lys Ile Thr Asp Lys Leu Leu Ala Tyr Glu Asp Leu Ser Val Phe 
            500                 505                 510         


Ile Tyr Ser Val Pro Tyr Tyr Tyr Lys Asp Ala Lys Gly Leu Leu Lys 
        515                 520                 525             


Ile Glu Tyr Thr Asn Gln Lys Glu Ile Glu His Ala Gly Ala Leu Glu 
    530                 535                 540                 


Arg Thr Ser Lys Arg Arg Arg Gln Asp Tyr Asp Ser Ser Asp Asp Glu 
545                 550                 555                 560 


Glu Asp 
        


<210>  21
<211>  653
<212>  PRT
<213>  Marchantia polymorpha

<400>  21

Met Glu Arg Leu Leu Thr Lys Ile Arg Asp Leu Glu Lys Glu Ala Leu 
1               5                   10                  15      


Asn Ile Ala Ser Lys Gln Glu Arg Lys Arg Ile Arg Ile Lys Glu Thr 
            20                  25                  30          


Asn Glu Glu Cys Cys Trp His Cys Glu Gly Gln Asp Trp Ile Asn Asp 
        35                  40                  45              


Val Arg Leu Lys Gly Gly Glu Trp Thr Gly Lys Pro Leu Val Val Leu 
    50                  55                  60                  


Ser Leu Phe Asp Gly Ile Gly Gly Val Trp Val Ala Leu Glu Arg Leu 
65                  70                  75                  80  


Gly Ile Pro Phe Val Gly Tyr Ser Cys Glu Val Asn Asp Ala Ala Met 
                85                  90                  95      


Gln Val Ile Lys His Arg Tyr Gly Met Val Arg His Leu Gly Asp Val 
            100                 105                 110         


Lys Glu Leu Glu Lys Ala Asp Ile Pro Glu Lys Val Asp Leu Ile Ile 
        115                 120                 125             


Gly Gly Phe Pro Cys Gln Asp Leu Ser Ser Leu Gly His Lys Met Gly 
    130                 135                 140                 


Leu His Gly Gln Arg Ser Lys Leu Phe Phe Glu Met Leu Arg Ile Ile 
145                 150                 155                 160 


Lys Ile Phe Asn Pro Thr Trp Phe Leu Ala Glu Asn Val Ala Ser Met 
                165                 170                 175     


Thr Trp Ile Asp Arg Gln Glu Ile Ser Lys His Leu Asn Thr Thr Pro 
            180                 185                 190         


Ile Glu Ile Asp Ala Glu Glu Ile Thr Pro Ser Lys Arg Arg Arg Ile 
        195                 200                 205             


Tyr Trp Ser Asn Ile Pro Tyr Pro Asn Lys Ile Pro Arg Ile Arg Asp 
    210                 215                 220                 


His Glu Ser Thr Ala Leu Gln Ser Val Leu His Asn Ala Thr Ala Leu 
225                 230                 235                 240 


Asp Lys Lys Val Gly Cys Ile Leu Ser Gln Asn Asn His Lys Ala Gly 
                245                 250                 255     


Tyr Gly Ser Leu Glu Leu Val Met Asp Asn Asn Thr Asn Lys Leu Arg 
            260                 265                 270         


Tyr Ile Ser Val Ile Glu Thr Glu Leu Ala Met Gly Tyr Pro Pro Gly 
        275                 280                 285             


Tyr Thr Asn Val Lys Phe Asn His Ser Cys Glu Lys Lys Thr Ile Ser 
    290                 295                 300                 


Ser Thr Ala Asn Tyr Arg Thr Glu Val Asn Ile Thr Asn Ile Thr Arg 
305                 310                 315                 320 


Arg Ala Gly Glu Lys Met Leu Arg Ser Lys Arg Ile Val Gln Ser Ser 
                325                 330                 335     


Gln Arg Leu Val Glu Glu Met Ser Ser Val Lys Ser Ser Ser Phe Ala 
            340                 345                 350         


Asp Gly Ile Asn Arg Ser Ala Arg Trp His Leu Leu Gly Asn Thr Phe 
        355                 360                 365             


Ser Val Pro Val Ile Cys Tyr Leu Leu Ser Pro Leu Leu Tyr Arg Glu 
    370                 375                 380                 


Val Arg Ala Ala Pro Ile Pro Ile Ser Leu Pro Lys Tyr Ile Lys Glu 
385                 390                 395                 400 


Gln Asp Cys Ser Ala Met Asp Pro Gly Glu Val Trp Ala Leu Tyr Asn 
                405                 410                 415     


Ser His Glu Arg Pro Asn Trp Tyr Ala Val Ile Val Ser Arg Ser Gly 
            420                 425                 430         


Asp Arg Phe Ser Asp Val Arg Ile Gln Leu Gly Arg Lys Arg Pro Pro 
        435                 440                 445             


Ile Tyr Ile Glu Val Lys Phe Met Glu Met Thr Ser Ala Tyr Ala Ala 
    450                 455                 460                 


Gly Glu Pro Asp Asn Trp Asp Thr Asn Arg Gly Thr Gly Leu Phe His 
465                 470                 475                 480 


Leu Arg Glu Leu Ile Asp Lys Gln Asn Ser Trp Val Ala Phe Ser His 
                485                 490                 495     


Arg Val Ser Thr Phe Leu His Phe Asp Asn His Tyr Phe Met Tyr Pro 
            500                 505                 510         


Gly Lys Asp Glu Val Trp Ala Ile Tyr Asp Asn Ala Ala Lys Cys Arg 
        515                 520                 525             


Tyr Leu Val Tyr Val Leu Thr Ser Glu Ile Asp Arg Gln Lys Ala Lys 
    530                 535                 540                 


Leu Gly Lys Pro Gly Lys Glu Gly Phe His Ala Arg Cys Arg Leu Leu 
545                 550                 555                 560 


Gln Arg Thr Glu Asn Glu Val Tyr Arg Phe Met Asp Ala Glu Leu Asp 
                565                 570                 575     


Leu Thr Asp Leu Ser Ile Phe Ala Phe Arg Ala Pro Phe His Tyr Lys 
            580                 585                 590         


Asn Glu Ser Asn Leu Leu Arg Ile Glu Leu Thr Leu Arg Gln Arg Lys 
        595                 600                 605             


Gln Gly Pro Glu Asn Asp Lys Gln Asn Cys Lys Arg Arg Lys Arg Tyr 
    610                 615                 620                 


Ser Asp Ser Asp Glu Asp Asp Glu Glu Asp Glu Val Glu Ala Thr Asp 
625                 630                 635                 640 


Ser Glu Ala Val Val Thr Ala Glu Asp Asp Ser Gly Arg 
                645                 650             


<210>  22
<211>  686
<212>  PRT
<213>  Marchantia polymorpha

<400>  22

Met Asp Lys Val Leu Asn His Ile Arg Asn Leu Arg Ala Glu Ala Glu 
1               5                   10                  15      


Ser Leu Leu Lys Asn Gly Asn Arg His Asp Gly Asp Asp Glu Ala His 
            20                  25                  30          


Cys Gly Val Glu Lys Ser Ile Asp Cys Ser Asn Cys Gly Gly Asp Arg 
        35                  40                  45              


Trp Val Leu Lys Leu Arg Gln Lys Ala Gly Phe Trp Arg Ser Lys Pro 
    50                  55                  60                  


Leu Val Val Leu Ser Leu Phe Asp Gly Ile Gly Gly Val Trp Ala Ala 
65                  70                  75                  80  


Leu Glu Asn Leu Gly Ile Pro Phe Ile Gly Tyr Ser Cys Glu Val Asn 
                85                  90                  95      


Ala Asp Ala Met Lys Val Thr Gln Arg Asn Tyr Cys Ser Val Arg His 
            100                 105                 110         


Leu Gly Asp Ile His Arg Leu Lys Lys Ala Asp Ile Lys Glu Lys Ile 
        115                 120                 125             


Asp Leu Val Val Gly Gly Phe Pro Cys Gln Asp Leu Ser Ser Met Gly 
    130                 135                 140                 


Ala Arg Leu Gly Leu His Gly Ser Arg Ser Arg Leu Phe Phe Glu Met 
145                 150                 155                 160 


Leu Arg Val Ile Lys Thr Phe Ser Pro Thr Trp Phe Leu Ala Glu Asn 
                165                 170                 175     


Val Ala Ser Met Ser Trp Val Asp Arg Glu Glu Ile Ser Lys His Leu 
            180                 185                 190         


Ser Thr Thr Pro Leu Glu Ile Asp Ser Gln Asn Phe Ser Pro Cys Lys 
        195                 200                 205             


Arg Arg Arg Leu Tyr Trp Ser Asn Ile Pro Tyr Pro Lys Thr Cys Pro 
    210                 215                 220                 


Arg Ile Gly Asp Asn Glu Ala Thr Ser Ile Gln Ser Val Val Gln Gly 
225                 230                 235                 240 


Gly Ala Ser Leu Ala Lys Lys Asn Met Cys Val Leu Ser Ser Asn Gly 
                245                 250                 255     


Leu Gln Gly Ala Thr Lys Ala Leu Met Glu Leu Val Tyr Asp Phe Arg 
            260                 265                 270         


Ile Asp Lys Pro Arg Tyr Ile Asn Val Val Glu Val Glu Gln Met Met 
        275                 280                 285             


Gly Tyr Pro Pro His Tyr Thr Asn Val Lys Phe Asp Asp Gln Lys Pro 
    290                 295                 300                 


Lys Ala Lys Ile Gln Arg Arg Arg Glu Thr Glu Ile Lys Glu Gly Gly 
305                 310                 315                 320 


Val Asp Arg Asn Thr Arg Trp Arg Leu Leu Gly Asn Ser Phe Ser Val 
                325                 330                 335     


Pro Val Ile Ser Phe Leu Leu Ser Pro Leu Leu Asp Ala Asp Ile Arg 
            340                 345                 350         


Asp Gln Thr Arg Lys Tyr His Leu Pro Ala Ser Val Arg Glu Ala Asp 
        355                 360                 365             


Cys Ser Val Met Ser Pro Gly Glu Ile Trp Ala Met Tyr Asn Ile His 
    370                 375                 380                 


Gln Arg Pro Asn Trp Tyr Val Gln Ile Val Ser Arg Ser Gly Glu Arg 
385                 390                 395                 400 


Phe Asp Leu Asn Val Asn Glu Arg Gly Lys Lys Gly Ser Arg Leu Pro 
                405                 410                 415     


Leu Arg Ile Glu Cys Arg Phe Leu Glu Leu Thr Lys Pro Tyr Glu Ala 
            420                 425                 430         


Gly Gln Leu Asp Leu Trp Ser Thr Ile Arg Gly Cys Gly Leu Tyr Thr 
        435                 440                 445             


Val Ser Glu Gly Ile Glu Val Gln Gly Ser Trp Val Ala Phe Ser His 
    450                 455                 460                 


Gln Val Thr Ser Leu Leu Lys Val Asp His Gly Leu Ile Phe Ile Tyr 
465                 470                 475                 480 


Pro Ala Lys Gly Glu Val Trp Ser Val Tyr Asp Ser Gly Thr Glu Ser 
                485                 490                 495     


Arg Tyr Leu Val Tyr Val Leu Glu Ser Ser Val Asn Thr Lys Lys Ala 
            500                 505                 510         


Lys Leu Arg Val Pro Gly Lys Glu Gly Phe Ser Ala Arg Cys Arg Leu 
        515                 520                 525             


Leu Gln Lys Lys Ile Glu Leu Asp Leu Tyr Arg Ile Ile Asp Lys Glu 
    530                 535                 540                 


Leu Val Tyr Thr Asp Leu Gly Val Phe Ser Phe Arg Ala Pro Tyr His 
545                 550                 555                 560 


Phe His Gly Glu Gly Asp Val Leu Lys Ile Glu Leu Ser Val Lys Asp 
                565                 570                 575     


Arg Glu Arg Gly Ala Gln Ile Asp Gly Leu Lys Arg Lys Arg Leu Ser 
            580                 585                 590         


Arg His Phe Glu Ser Asp Asp Glu Asp Phe Leu Asp Met Asp Ile Gly 
        595                 600                 605             


Asp Glu Phe Gly Ala Met Pro Ile Ala Ile Gly Asn Ile Thr Ser Glu 
    610                 615                 620                 


Pro Leu Ala Asn Gly Glu Ser Lys Ser Glu Ser Ile Leu Thr Val Val 
625                 630                 635                 640 


Thr Lys Arg Asp Glu Glu Arg Leu Val Gln Pro Lys Glu Asp Ala Ile 
                645                 650                 655     


Arg Gly His Leu Glu Pro Leu Lys Leu Lys Pro Ala Pro Arg Arg Ser 
            660                 665                 670         


Ser Arg Ser Thr Ala Gly Leu Arg Ser Thr Pro Tyr Thr Pro 
        675                 680                 685     


<210>  23
<211>  1367
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of the catalytically inactive S. pyogenes 
       Cas9

<400>  23

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  24
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  24
ggatcctgga acgcaaaaca agaccg                                            26


<210>  25
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  25
ggaggtggat ccaattgttc tttc                                              24


<210>  26
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  26
gcatgcttcc cctggcagaa atttgg                                            26


<210>  27
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  27
gcatgcggcc gcgagcatca aattagagct tcaggg                                 36


<210>  28
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  28
ggatccgtgg tgaacctagt tgtccattgg                                        30


<210>  29
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  29
ggatcctggc gtgtaaagct cacactaa                                          28


<210>  30
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  30
gcatgcgttt gccttgcctt gttccttc                                          28


<210>  31
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  31
gcatgcggcc gccatccttt tgcaacaatc ctcc                                   34


<210>  32
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  32
aagcttgtcg tgctgagtat tcagataatc gtagc                                  35


<210>  33
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  33
aagcttaatc caactgttcc aattccgc                                          28


<210>  34
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  34
gcatgctagc tctcttgaag tatccg                                            26


<210>  35
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  35
aatcgtgctt tctaccacat actgcc                                            26


<210>  36
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  36
aagcttcggg tttcggagtt ctgggtt                                           27


<210>  37
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  37
aagcttgcag gccagaggaa agagcg                                            26


<210>  38
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  38
gcatgcccat gttccaatct tttgacttgc c                                      31


<210>  39
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  39
acattccgtt taccagtagc atctgg                                            26


<210>  40
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  40
ggtaccgtca acatggtgga gcacgaca                                          28


<210>  41
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  41
gcatgccagg tcactggatt ttggttttag g                                      31


<210>  42
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  42
ggaacacggt ggatgtattc cttct                                             25


<210>  43
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  43
aggcggtatg gttgtgccac c                                                 21


<210>  44
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  44
ggtcaaggtc gaatcatctc aacg                                              24


<210>  45
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  45
gcgttgggat gtttggagca                                                   20


<210>  46
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  46
gacaatttcc attcatgcga gttgtc                                            26


<210>  47
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  47
caagccatgc ctattgttat cactgttc                                          28


<210>  48
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  48
attggctttg gtcttcctgg tca                                               23


<210>  49
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  49
tgtgggaatt gcagtggcgt                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  50
gctgcaagcg tgagcgattc                                                   20


<210>  51
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  51
gggttggata tcactaagct ccacc                                             25


<210>  52
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  52
gctgaccaat ctaggcatcc cg                                                22


<210>  53
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  53
tggagggctt gatttaggca gag                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  54
gctgatgact gcttgagcct tcg                                               23


<210>  55
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  55
tccactcgtc tacttcttct ttgagatagg                                        30


<210>  56
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  56
ggtcgggtga acggctgg                                                     18


<210>  57
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  57
aaggctatcc tgtcgagttg gctt                                              24


<210>  58
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  58
tgggaccact gtcggcagag                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  59
gcccccgctt aaaaattggt                                                   20


<210>  60
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  60
aagtagagaa aggaaagaga aaagggg                                           27


<210>  61
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  61
tgggaccact gtcggcagag                                                   20


<210>  62
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  62
aagtagagaa aggaaagaga aaagggg                                           27


<210>  63
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  63
ctgtattttt ctcccttca                                                    19


<210>  64
<211>  5808
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid sequence of 
       FLAG-NLS-dcas9-NLS-PpDNMT3b_MTD-T2A-PuroR

<400>  64
atggactata aggaccacga cggagactac aaggatcatg atattgatta caaagacgat       60

gacgataaga tggccccaaa gaagaagcgg aaggtcggta tccacggagt cccagcagcc      120

gacaagaagt acagcatcgg cctggccatc ggcaccaact ctgtgggctg ggccgtgatc      180

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      240

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      300

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      360

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      420

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      480

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      540

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      600

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      660

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      720

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      780

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggcaacctg      840

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      900

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      960

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg     1020

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg     1080

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1140

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1200

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1260

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1320

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1380

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1440

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1500

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1560

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1620

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1680

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1740

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1800

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1860

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1920

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1980

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     2040

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     2100

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2160

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2220

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2280

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2340

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2400

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2460

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2520

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2580

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggacgctatc     2640

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2700

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2760

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2820

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2880

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2940

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     3000

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     3060

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3120

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3180

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3240

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3300

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3360

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3420

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3480

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3540

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3600

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3660

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3720

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3780

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3840

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3900

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3960

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     4020

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     4080

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4140

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4200

ctgtctcagc tgggaggcga caaaaggccg gcggccacga aaaaggccgg acaggccaaa     4260

aagaaaaagc tcgagggcgg aggcgggagc ggatccgcag aggcaggccc ctggtccgga     4320

gagcgcctgg tggtgctgtc tctgttcgac ggcctgggag gcatctggca ggccctgacc     4380

aagctgggca tccctttttc tggatactct agcgaggtgc tggccccagc aatccaggtg     4440

gtgaagagcc gccaccctcg ggtgaagcac gtgggcgaca tccggaagct gaacctgagc     4500

gccgtgccag agaaggtgga cctggtggtg ggaggattcc catgccagga tctgtccatc     4560

atgggcaaga aggagggcct gcacggctcc cggtctaagc tgttctttga cctgctgaga     4620

gtgctgaagg tgttcaagcc taagtggttt ctggtggaga atgtggccag catgtcctgg     4680

gtggacaggg aggagatcac acgccacctg aaggtggccc caatggagct ggattctcag     4740

gagatcaccg ccagcaagcg gagaaggctg tattggacaa acatcccaca cccacctaga     4800

ctgccccgcc tgcgggatca ccccagcacc agcctccagt cctgtctgga gggcgccctg     4860

gccctggagc agaagtgcgg cgtgatcctg tgcagcaatc tgtacaaggg ctctaccgca     4920

cggctggagc tggtgctgga caacaagacc aataagctga gatatatcaa gcagacagag     4980

gtggaggtgc tgatgggcta cccaaaggat tataccaacg tggtggccca cgagacaaag     5040

ggcaggacag agcaggccga gaaggtgctg aaaacccccg tgcgcgcaaa gagcgtggag     5100

cctaagccat cctctgtgac accaccctcc ggccggcccg aattcggcag tggagagggc     5160

agaggaagtc tgctaacatg cggtgacgtc gaggagaatc ctggcccaat gaccgagtac     5220

aagcccacgg tgcgcctcgc cacccgcgac gacgtcccca gggccgtacg caccctcgcc     5280

gccgcgttcg ccgactaccc cgccacgcgc cacaccgtcg atccggaccg ccacatcgag     5340

cgggtcaccg agctgcaaga actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg     5400

tgggtcgcgg acgacggcgc cgcggtggcg gtctggacca cgccggagag cgtcgaagcg     5460

ggggcggtgt tcgccgagat cggcccgcgc atggccgagt tgagcggttc ccggctggcc     5520

gcgcagcaac agatggaagg cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc     5580

ctggccaccg tcggcgtctc gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg     5640

ctccccggag tggaggcggc cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg     5700

ccccacaacc tccccttcta cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg     5760

cccgaaggac cgcgcacctg gtgcatgacc cgcaagcccg gtgcctga                  5808


<210>  65
<211>  1735
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of FLAG-NLS-dcas9-NLS-PpDNMT3b_MTD-T2A-PuroR

<400>  65

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu 
        35                  40                  45              


Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
    50                  55                  60                  


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
65                  70                  75                  80  


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
                85                  90                  95      


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
            100                 105                 110         


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
        115                 120                 125             


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
    130                 135                 140                 


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
145                 150                 155                 160 


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
                165                 170                 175     


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
            180                 185                 190         


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
        195                 200                 205             


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
    210                 215                 220                 


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
225                 230                 235                 240 


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
                245                 250                 255     


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
            260                 265                 270         


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
        275                 280                 285             


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
    290                 295                 300                 


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
305                 310                 315                 320 


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
                325                 330                 335     


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
            340                 345                 350         


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
        355                 360                 365             


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
    370                 375                 380                 


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
385                 390                 395                 400 


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
                405                 410                 415     


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
            420                 425                 430         


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
        435                 440                 445             


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
    450                 455                 460                 


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
465                 470                 475                 480 


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
                485                 490                 495     


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
            500                 505                 510         


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
        515                 520                 525             


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
    530                 535                 540                 


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
545                 550                 555                 560 


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
                565                 570                 575     


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
            580                 585                 590         


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
        595                 600                 605             


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
    610                 615                 620                 


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
625                 630                 635                 640 


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
                645                 650                 655     


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
            660                 665                 670         


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
        675                 680                 685             


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
    690                 695                 700                 


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
705                 710                 715                 720 


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
                725                 730                 735     


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
            740                 745                 750         


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
        755                 760                 765             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
    770                 775                 780                 


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
785                 790                 795                 800 


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
                805                 810                 815     


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
            820                 825                 830         


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
        835                 840                 845             


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
    850                 855                 860                 


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile 
865                 870                 875                 880 


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
                885                 890                 895     


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
            900                 905                 910         


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
        915                 920                 925             


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
    930                 935                 940                 


Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
945                 950                 955                 960 


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 
                965                 970                 975     


Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val 
            980                 985                 990         


Lys Val Ile Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
        995                 1000                 1005             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1010                 1015                 1020             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1040                 1045                 1050             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1055                 1060                 1065             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1070                 1075                 1080             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1085                 1090                 1095             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1100                 1105                 1110             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1115                 1120                 1125             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1130                 1135                 1140             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1145                 1150                 1155             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1160                 1165                 1170             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1175                 1180                 1185             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1190                 1195                 1200             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1205                 1210                 1215             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1220                 1225                 1230             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1235                 1240                 1245             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1250                 1255                 1260             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1265                 1270                 1275             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1280                 1285                 1290             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1295                 1300                 1305             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1310                 1315                 1320             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1325                 1330                 1335             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1340                 1345                 1350             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1355                 1360                 1365             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1370                 1375                 1380             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1385                 1390                 1395             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Lys Arg Pro  Ala Ala Thr 
    1400                 1405                 1410             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys Leu Glu  Gly Gly Gly 
    1415                 1420                 1425             


Gly Ser  Gly Ser Ala Glu Ala  Gly Pro Trp Ser Gly  Glu Arg Leu 
    1430                 1435                 1440             


Val Val  Leu Ser Leu Phe Asp  Gly Leu Gly Gly Ile  Trp Gln Ala 
    1445                 1450                 1455             


Leu Thr  Lys Leu Gly Ile Pro  Phe Ser Gly Tyr Ser  Ser Glu Val 
    1460                 1465                 1470             


Leu Ala  Pro Ala Ile Gln Val  Val Lys Ser Arg His  Pro Arg Val 
    1475                 1480                 1485             


Lys His  Val Gly Asp Ile Arg  Lys Leu Asn Leu Ser  Ala Val Pro 
    1490                 1495                 1500             


Glu Lys  Val Asp Leu Val Val  Gly Gly Phe Pro Cys  Gln Asp Leu 
    1505                 1510                 1515             


Ser Ile  Met Gly Lys Lys Glu  Gly Leu His Gly Ser  Arg Ser Lys 
    1520                 1525                 1530             


Leu Phe  Phe Asp Leu Leu Arg  Val Leu Lys Val Phe  Lys Pro Lys 
    1535                 1540                 1545             


Trp Phe  Leu Val Glu Asn Val  Ala Ser Met Ser Trp  Val Asp Arg 
    1550                 1555                 1560             


Glu Glu  Ile Thr Arg His Leu  Lys Val Ala Pro Met  Glu Leu Asp 
    1565                 1570                 1575             


Ser Gln  Glu Ile Thr Ala Ser  Lys Arg Arg Arg Leu  Tyr Trp Thr 
    1580                 1585                 1590             


Asn Ile  Pro His Pro Pro Arg  Leu Pro Arg Leu Arg  Asp His Pro 
    1595                 1600                 1605             


Ser Thr  Ser Leu Gln Ser Cys  Leu Glu Gly Ala Leu  Ala Leu Glu 
    1610                 1615                 1620             


Gln Lys  Cys Gly Val Ile Leu  Cys Ser Asn Leu Tyr  Lys Gly Ser 
    1625                 1630                 1635             


Thr Ala  Arg Leu Glu Leu Val  Leu Asp Asn Lys Thr  Asn Lys Leu 
    1640                 1645                 1650             


Arg Tyr  Ile Lys Gln Thr Glu  Val Glu Val Leu Met  Gly Tyr Pro 
    1655                 1660                 1665             


Lys Asp  Tyr Thr Asn Val Val  Ala His Glu Thr Lys  Gly Arg Thr 
    1670                 1675                 1680             


Glu Gln  Ala Glu Lys Val Leu  Lys Thr Pro Val Arg  Ala Lys Ser 
    1685                 1690                 1695             


Val Glu  Pro Lys Pro Ser Ser  Val Thr Pro Pro Ser  Gly Arg Pro 
    1700                 1705                 1710             


Glu Phe  Gly Ser Gly Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly 
    1715                 1720                 1725             


Asp Val  Glu Glu Asn Pro Gly  
    1730                 1735 


<210>  66
<211>  821
<212>  DNA
<213>  Artificial sequence

<220>
<223>  An example of a human codon optimized nucleic acid sequence 
       encoding DNMT3

<400>  66
ggcccctggt ccggagagcg cctggtggtg ctgtctctgt tcgacggcct gggaggcatc       60

tggcaggccc tgaccaagct gggcatccct ttttctggat actctagcga ggtgctggcc      120

ccagcaatcc aggtggtgaa gagccgccac cctcgggtga agcacgtggg cgacatccgg      180

aagctgaacc tgagcgccgt gccagagaag gtggacctgg tggtgggagg attcccatgc      240

caggatctgt ccatcatggg caagaaggag ggcctgcacg gctcccggtc taagctgttc      300

tttgacctgc tgagagtgct gaaggtgttc aagcctaagt ggtttctggt ggagaatgtg      360

gccagcatgt cctgggtgga cagggaggag atcacacgcc acctgaaggt ggccccaatg      420

gagctggatt ctcaggagat caccgccagc aagcggagaa ggctgtattg gacaaacatc      480

ccacacccac ctagactgcc ccgcctgcgg gatcacccca gcaccagcct ccagtcctgt      540

ctggagggcg ccctggccct ggagcagaag tgcggcgtga tcctgtgcag caatctgtac      600

aagggctcta ccgcacggct ggagctggtg ctggacaaca agaccaataa gctgagatat      660

atcaagcaga cagaggtgga ggtgctgatg ggctacccaa aggattatac caacgtggtg      720

gcccacgaga caaagggcag gacagagcag gccgagaagg tgctgaaaac ccccgtgcgc      780

gcaaagagcg tggagcctaa gccatcctct gtgacaccac c                          821


<210>  67
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  An exemplary nucleic acid sequence of human-codon optimized Cas9

<400>  67
gacaagaagt acagcatcgg cctggccatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggcaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggacgctatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggcga c                                               4101


