                         SEQUENCE LISTING

<110>  Nuclera Nucleics Ltd
 
<120>  Method of Oligonucleotide Synthesis

<130>  P31216WO1

<160>  728  

<170>  PatentIn version 3.5

<210>  1
<211>  494
<212>  PRT
<213>  Lepisosteus oculatus

<400>  1

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  2
<211>  509
<212>  PRT
<213>  Bos taurus

<400>  2

Met Asp Pro Leu Cys Thr Ala Ser Ser Gly Pro Arg Lys Lys Arg Pro 
1               5                   10                  15      


Arg Gln Val Gly Ala Ser Met Ala Ser Pro Pro His Asp Ile Lys Phe 
            20                  25                  30          


Gln Asn Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg 
        35                  40                  45              


Arg Asn Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Ser Glu Val Leu Glu Trp Leu Gln Val Gln Asn Ile Arg Ala Ser 
                85                  90                  95      


Ser Gln Leu Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Ser Met Gly 
            100                 105                 110         


Ala Gly Lys Pro Val Glu Ile Thr Gly Lys His Gln Leu Val Val Arg 
        115                 120                 125             


Thr Asp Tyr Ser Ala Thr Pro Asn Pro Gly Phe Gln Lys Thr Pro Pro 
    130                 135                 140                 


Leu Ala Val Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Asn Asn Tyr Asn His Ile Phe Thr Asp Ala Phe Glu Ile Leu Ala 
                165                 170                 175     


Glu Asn Ser Glu Phe Lys Glu Asn Glu Val Ser Tyr Val Thr Phe Met 
            180                 185                 190         


Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met 
        195                 200                 205             


Lys Asp Thr Glu Gly Ile Pro Cys Leu Gly Asp Lys Val Lys Cys Ile 
    210                 215                 220                 


Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val 
225                 230                 235                 240 


Leu Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe 
                245                 250                 255     


Gly Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg 
            260                 265                 270         


Ser Leu Ser Lys Ile Met Ser Asp Lys Thr Leu Lys Phe Thr Lys Met 
        275                 280                 285             


Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr 
    290                 295                 300                 


Arg Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala Val Trp 
305                 310                 315                 320 


Ala Phe Leu Pro Asp Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg 
                325                 330                 335     


Gly Lys Lys Ile Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly 
            340                 345                 350         


Ser Ala Glu Asp Glu Glu Gln Leu Leu Pro Lys Val Ile Asn Leu Trp 
        355                 360                 365             


Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe 
    370                 375                 380                 


Glu Lys Phe Lys Leu Pro Ser Arg Gln Val Asp Thr Leu Asp His Phe 
385                 390                 395                 400 


Gln Lys Cys Phe Leu Ile Leu Lys Leu His His Gln Arg Val Asp Ser 
                405                 410                 415     


Ser Lys Ser Asn Gln Gln Glu Gly Lys Thr Trp Lys Ala Ile Arg Val 
            420                 425                 430         


Asp Leu Val Met Cys Pro Tyr Glu Asn Arg Ala Phe Ala Leu Leu Gly 
        435                 440                 445             


Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Ile Arg Arg Tyr Ala Thr 
    450                 455                 460                 


His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys Thr 
465                 470                 475                 480 


Lys Arg Val Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala His 
                485                 490                 495     


Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
            500                 505                 


<210>  3
<211>  530
<212>  PRT
<213>  Mus musculus

<400>  3

Met Asp Pro Leu Gln Ala Val His Leu Gly Pro Arg Lys Lys Arg Pro 
1               5                   10                  15      


Arg Gln Leu Gly Thr Pro Val Ala Ser Thr Pro Tyr Asp Ile Arg Phe 
            20                  25                  30          


Arg Asp Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg 
        35                  40                  45              


Arg Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Ser Asp Val Leu Glu Trp Leu Gln Leu Gln Asn Ile Lys Ala Ser 
                85                  90                  95      


Ser Glu Leu Glu Leu Leu Asp Ile Ser Trp Leu Ile Glu Cys Met Gly 
            100                 105                 110         


Ala Gly Lys Pro Val Glu Met Met Gly Arg His Gln Leu Val Val Asn 
        115                 120                 125             


Arg Asn Ser Ser Pro Ser Pro Val Pro Gly Ser Gln Asn Val Pro Ala 
    130                 135                 140                 


Pro Ala Val Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr 
145                 150                 155                 160 


Leu Asn Asn Tyr Asn Gln Leu Phe Thr Asp Ala Leu Asp Ile Leu Ala 
                165                 170                 175     


Glu Asn Asp Glu Leu Arg Glu Asn Glu Gly Ser Cys Leu Ala Phe Met 
            180                 185                 190         


Arg Ala Ser Ser Val Leu Lys Ser Leu Pro Phe Pro Ile Thr Ser Met 
        195                 200                 205             


Lys Asp Thr Glu Gly Ile Pro Cys Leu Gly Asp Lys Val Lys Ser Ile 
    210                 215                 220                 


Ile Glu Gly Ile Ile Glu Asp Gly Glu Ser Ser Glu Ala Lys Ala Val 
225                 230                 235                 240 


Leu Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr Ser Val Phe 
                245                 250                 255     


Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Phe Arg Met Gly Phe Arg 
            260                 265                 270         


Thr Leu Ser Lys Ile Gln Ser Asp Lys Ser Leu Arg Phe Thr Gln Met 
        275                 280                 285             


Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Asn 
    290                 295                 300                 


Arg Pro Glu Ala Glu Ala Val Ser Met Leu Val Lys Glu Ala Val Val 
305                 310                 315                 320 


Thr Phe Leu Pro Asp Ala Leu Val Thr Met Thr Gly Gly Phe Arg Arg 
                325                 330                 335     


Gly Lys Met Thr Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu 
            340                 345                 350         


Ala Thr Glu Asp Glu Glu Gln Gln Leu Leu His Lys Val Thr Asp Phe 
        355                 360                 365             


Trp Lys Gln Gln Gly Leu Leu Leu Tyr Cys Asp Ile Leu Glu Ser Thr 
    370                 375                 380                 


Phe Glu Lys Phe Lys Gln Pro Ser Arg Lys Val Asp Ala Leu Asp His 
385                 390                 395                 400 


Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu Asp His Gly Arg Val His 
                405                 410                 415     


Ser Glu Lys Ser Gly Gln Gln Glu Gly Lys Gly Trp Lys Ala Ile Arg 
            420                 425                 430         


Val Asp Leu Val Met Cys Pro Tyr Asp Arg Arg Ala Phe Ala Leu Leu 
        435                 440                 445             


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala 
    450                 455                 460                 


Thr His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Arg 
465                 470                 475                 480 


Thr Lys Gly Lys Thr Val Thr Ile Ser Pro Leu Asp Gly Lys Val Ser 
                485                 490                 495     


Lys Leu Gln Lys Ala Leu Arg Val Phe Leu Glu Ala Glu Ser Glu Glu 
            500                 505                 510         


Glu Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg 
        515                 520                 525             


Asn Ala 
    530 


<210>  4
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  4

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Leu 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Ile Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Asp Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  5
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  5

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Glu Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Trp Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  6
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  6

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Val Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  7
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  7

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Leu 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Pro Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  8
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  8

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ser Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  9
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  9

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Ile Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  10
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  10

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Ile 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asn Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  11
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  11

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Thr Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  12
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  12

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Asn Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  13
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  13

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Thr Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  14
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  14

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Val Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Ala Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  15
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  15

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Ile Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu His His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  16
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  16

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Val Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  17
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  17

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Ala Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  18
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  18

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn Cys Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asn Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  19
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  19

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Arg Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Arg Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  20
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  20

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Lys Gly Leu Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  21
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  21

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Ala Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  22
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  22

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Ala Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Thr Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  23
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  23

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Ile Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Arg Ala Ala Gly Arg Val Gln Lys Asn Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  24
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  24

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Arg Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  25
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  25

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ala Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Lys Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  26
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  26

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ser Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu His His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  27
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  27

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Asp Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  28
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  28

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Lys Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Cys Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  29
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  29

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Gly Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  30
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  30

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Arg Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  31
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  31

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asn Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Leu Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  32
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  32

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Ala Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Val Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  33
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  33

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ala Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Asn Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Gln Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  34
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  34

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  35
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  35

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Val Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Asp Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Arg Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  36
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  36

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asn Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu His His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Gln Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  37
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  37

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Arg Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Arg Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  38
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  38

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Arg Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  39
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  39

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Leu Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  40
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  40

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Ile 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Ala Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Glu Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  41
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  41

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Arg Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Gln 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Lys Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  42
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  42

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Ile Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  43
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  43

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Met Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  44
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  44

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ala Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  45
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  45

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asn Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  46
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  46

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Cys Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  47
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  47

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  48
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  48

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Arg Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Leu Pro Pro Val Asp Arg Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  49
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  49

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Val Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  50
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  50

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Ser Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  51
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  51

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ala Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Gly Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  52
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  52

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Arg Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  53
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  53

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  54
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  54

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  55
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  55

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Val Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Arg Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  56
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  56

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Glu Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  57
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  57

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Lys Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  58
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  58

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Ala Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Ser Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  59
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  59

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Ala Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asn Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ser Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  60
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  60

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  61
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  61

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Thr Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Lys Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Lys Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  62
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  62

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Arg Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  63
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  63

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asn Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Thr Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  64
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  64

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Asp Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Gln 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  65
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  65

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Pro Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Arg Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  66
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  66

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn Cys Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  67
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  67

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Gln Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  68
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  68

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  69
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  69

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Gly Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Ser Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  70
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  70

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Arg Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  71
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  71

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Leu 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Val Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Met Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  72
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  72

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Val Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Trp Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  73
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  73

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn Cys Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  74
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  74

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Glu Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Arg Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  75
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  75

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Trp Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  76
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  76

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ala Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Ser Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  77
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  77

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Trp Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  78
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  78

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Arg Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  79
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  79

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Val Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Trp Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  80
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  80

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp Ala Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  81
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  81

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  82
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  82

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Thr Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  83
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  83

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  84
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  84

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Arg Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  85
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  85

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  86
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  86

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Cys Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Tyr Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  87
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  87

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  88
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  88

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Asn Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Leu Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  89
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  89

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Leu 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Arg Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  90
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  90

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Arg 
            100                 105                 110         


Pro Val Gln Ser Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  91
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  91

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu His His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ser Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  92
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  92

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Arg 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  93
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  93

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  94
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  94

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Met Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Arg Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Leu Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  95
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  95

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Arg Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asn Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  96
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  96

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asn Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  97
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  97

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Trp Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Lys Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  98
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  98

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asn Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Asn Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  99
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  99

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Glu Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  100
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  100

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Arg Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  101
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  101

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Thr Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Gln 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  102
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  102

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asn Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Met Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  103
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  103

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  104
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  104

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Val Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Lys Ala Asp Asn 
            260                 265                 270         


Thr Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  105
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  105

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Ser Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Asn Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Cys Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  106
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  106

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp Ala Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Tyr Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  107
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  107

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Ile 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  108
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  108

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Thr Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Leu Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Arg Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  109
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  109

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asn Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ser Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  110
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  110

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Val Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  111
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  111

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ser Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp Ala Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  112
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  112

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Lys Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Arg Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  113
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  113

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Glu Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Cys Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  114
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  114

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Arg Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  115
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  115

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Arg Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  116
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  116

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Leu Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Arg Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  117
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  117

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Arg Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Trp Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Arg Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  118
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  118

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Arg 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu His His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Tyr Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  119
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  119

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  120
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  120

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Lys Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  121
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  121

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Arg Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Arg Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  122
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  122

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Ala Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  123
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  123

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asn Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Gln 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Lys Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  124
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  124

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Asn Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  125
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  125

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asn Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  126
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  126

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Ile 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Ile Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Leu Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  127
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  127

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Gly Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Ser Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  128
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  128

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Lys Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  129
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  129

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Arg Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  130
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  130

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ala Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ser Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Tyr Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  131
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  131

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Glu Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ser Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  132
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  132

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Ser Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  133
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  133

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Ile Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  134
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  134

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  135
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  135

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Arg Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Lys Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  136
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  136

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ala Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Val Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  137
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  137

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Trp Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  138
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  138

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Arg Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Arg Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Asn Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  139
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  139

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  140
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  140

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asn Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Ser Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  141
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  141

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Val Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn Cys Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Arg Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  142
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  142

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Val Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Pro Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  143
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  143

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ser Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  144
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  144

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Arg Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  145
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  145

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Ala Val Glu Thr Val Ser Pro Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  146
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  146

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asn Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Lys Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  147
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  147

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Arg 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Ser Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Gln Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  148
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  148

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Lys Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  149
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  149

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  150
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  150

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Ile Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Arg Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  151
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  151

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  152
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  152

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Ile Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  153
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  153

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ala Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp Ala Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  154
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  154

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp Ala Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  155
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  155

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Arg Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  156
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  156

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Ile Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Ser Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Gln Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  157
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  157

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ala Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Ile Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Cys Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  158
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  158

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Ala Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Tyr Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  159
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  159

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Asn Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  160
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  160

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Ala Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  161
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  161

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Arg Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  162
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  162

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Ile Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Ala Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  163
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  163

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Arg Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Met Ala Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Lys Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  164
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  164

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Ala Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Glu Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Lys Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  165
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  165

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  166
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  166

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Lys Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  167
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  167

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Gly Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Asn Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  168
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  168

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asn Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Ala Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  169
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  169

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Arg Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Gln Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Glu Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  170
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  170

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Arg 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  171
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  171

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Ile Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Glu Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  172
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  172

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Leu His Thr Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  173
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  173

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Glu Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Arg Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Lys Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
                485                 490                 


<210>  174
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  174

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Asp Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  175
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  175

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Trp Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  176
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  176

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Val Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  177
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  177

Thr Val Ser Pro Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  178
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  178

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ser Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Ile Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  179
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  179

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  180
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  180

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asn Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  181
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  181

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Thr Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  182
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  182

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Asn Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  183
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  183

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Lys Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Thr Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  184
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  184

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  185
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  185

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu His His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  186
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  186

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Val Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  187
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  187

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Ile Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  188
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  188

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn Cys 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asn Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  189
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  189

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Arg Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Arg Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  190
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  190

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  191
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  191

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Lys Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  192
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  192

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Thr Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  193
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  193

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Arg Ala Ala Gly Arg Val Gln Lys Asn Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  194
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  194

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  195
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  195

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Lys Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  196
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  196

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu His His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  197
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  197

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Asp Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  198
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  198

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Lys Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  199
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  199

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Lys Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  200
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  200

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Arg Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  201
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  201

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asn Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Leu Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  202
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  202

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Val Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  203
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  203

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Asn Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Gln Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  204
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  204

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  205
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  205

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Asp Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Arg Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  206
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  206

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu His His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Gln Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  207
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  207

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Arg Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  208
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  208

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Val Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Arg Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  209
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  209

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Leu Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  210
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  210

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Glu Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  211
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  211

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  212
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  212

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  213
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  213

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Met Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  214
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  214

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  215
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  215

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  216
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  216

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  217
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  217

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  218
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  218

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Leu Pro Pro Val Asp Arg Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  219
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  219

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  220
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  220

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Ser Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  221
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  221

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  222
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  222

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  223
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  223

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  224
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  224

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  225
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  225

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Arg Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  226
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  226

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Glu Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  227
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  227

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  228
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  228

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Ser Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  229
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  229

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ser Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  230
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  230

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Arg His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  231
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  231

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Lys Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  232
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  232

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  233
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  233

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Thr Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  234
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  234

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Asp Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  235
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  235

Thr Val Ser Pro Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Arg Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  236
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  236

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn Cys 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  237
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  237

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Gln Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  238
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  238

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  239
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  239

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Ser Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  240
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  240

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Arg Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  241
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  241

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Met Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  242
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  242

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Val Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Trp Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  243
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  243

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn Cys 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  244
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  244

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Glu Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Arg Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  245
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  245

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Trp Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  246
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  246

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Ser Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Ile Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  247
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  247

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Trp Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  248
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  248

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  249
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  249

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Val Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Trp Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  250
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  250

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Lys Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp Ala Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  251
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  251

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  252
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  252

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  253
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  253

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Ile Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  254
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  254

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  255
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  255

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Val Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  256
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  256

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Tyr Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  257
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  257

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  258
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  258

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Asn Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Leu Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  259
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  259

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Arg Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  260
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  260

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  261
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  261

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu His His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ser Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  262
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  262

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  263
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  263

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Lys Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  264
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  264

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Met Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Arg Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Leu Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  265
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  265

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  266
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  266

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  267
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  267

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Trp Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Lys Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  268
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  268

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Asn Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  269
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  269

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  270
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  270

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Arg Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  271
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  271

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  272
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  272

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Met Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  273
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  273

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  274
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  274

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Val Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Lys Ala Asp Asn Thr Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  275
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  275

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Ser Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Asn Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  276
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  276

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp Ala Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Tyr Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  277
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  277

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  278
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  278

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Arg Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  279
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  279

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  280
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  280

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  281
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  281

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp Ala Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  282
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  282

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Arg Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  283
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  283

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  284
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  284

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Arg Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  285
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  285

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Lys Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  286
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  286

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Arg Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  287
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  287

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Trp Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Arg Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  288
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  288

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu His His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Tyr Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  289
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  289

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Lys Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  290
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  290

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  291
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  291

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Arg Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  292
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  292

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  293
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  293

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  294
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  294

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Asn Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  295
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  295

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  296
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  296

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  297
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  297

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Ser Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  298
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  298

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Lys Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  299
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  299

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  300
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  300

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ser Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Tyr Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  301
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  301

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ser Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  302
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  302

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Ser Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Val Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  303
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  303

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  304
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  304

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Val Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  305
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  305

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Arg Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  306
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  306

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Val Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  307
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  307

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Trp Ala Arg His Glu Arg Lys Met Ile Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  308
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  308

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Asn Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  309
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  309

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  310
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  310

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Ser Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  311
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  311

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn Cys 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Arg Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  312
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  312

Thr Val Ser Pro Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  313
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  313

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  314
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  314

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Arg Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  315
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  315

Thr Val Ser Pro Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  316
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  316

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Lys Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  317
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  317

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Ser Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Gln Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  318
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  318

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Lys Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  319
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  319

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Leu His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  320
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  320

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Arg Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  321
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  321

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Lys Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  322
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  322

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  323
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  323

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Gln Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp Ala Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  324
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  324

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Pro Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp Ala Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  325
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  325

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Arg Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Arg Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  326
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  326

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Ser Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Gln Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  327
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  327

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  328
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  328

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Lys Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Tyr Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  329
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  329

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Val Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Asn Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  330
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  330

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  331
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  331

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  332
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  332

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Gln Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  333
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  333

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Arg Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Met Ala Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Lys Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  334
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  334

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Lys Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  335
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  335

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Thr Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  336
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  336

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Lys Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Lys Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  337
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  337

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Ser Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Asn Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  338
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  338

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  339
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  339

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Ala Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  340
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  340

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Lys Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  341
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  341

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Glu Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  342
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  342

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Gln Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Arg Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Leu His Thr Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Asn Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  343
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequences

<400>  343

Thr Val Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His 
1               5                   10                  15      


Asn Arg Ile Phe Thr Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Asn Glu Ser Glu Gly Pro Cys Leu Ala Phe Arg Arg Ala Ala Ser 
        35                  40                  45              


Leu Leu Lys Ser Leu Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu 
    50                  55                  60                  


Gly Leu Pro Cys Leu Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Gly Gln Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp 
                85                  90                  95      


Arg Tyr Gln Thr Ile Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
            100                 105                 110         


Lys Thr Ala Glu Lys Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu 
        115                 120                 125             


Val Gln Ala Asp Lys Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly 
    130                 135                 140                 


Phe Leu Tyr Tyr Asp Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala 
145                 150                 155                 160 


Asp Ala Ile Gly Gln Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro 
                165                 170                 175     


Asp Ala Ile Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys 
            180                 185                 190         


Gly His Asp Val Asp Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu 
        195                 200                 205             


Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu Leu 
    210                 215                 220                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro 
225                 230                 235                 240 


Cys Arg Lys Phe Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile 
                245                 250                 255     


Ile Lys Leu Lys Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp 
            260                 265                 270         


Lys Ala Ile Arg Val Asp Phe Val Ala Cys Pro Val Asp Asn Phe Ala 
        275                 280                 285             


Phe Ala Leu Leu Gly Trp Thr Gly Ser Lys Gln Phe Glu Arg Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ala Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala 
305                 310                 315                 320 


Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu 
                325                 330                 335     


Asp Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Pro Pro Trp Gln Arg 
            340                 345                 350         


Asn Ala 
        


<210>  344
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  344

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Val Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Phe Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Val Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  345
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  345

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Cys Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  346
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  346

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Ile Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Asp Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  347
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  347

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Thr Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr His Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  348
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  348

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Ile Asp Arg Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  349
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  349

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  350
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  350

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Thr 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Gln Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  351
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  351

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  352
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  352

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  353
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  353

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Arg Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  354
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  354

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Leu Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  355
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  355

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  356
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  356

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  357
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  357

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  358
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  358

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Ile Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  359
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  359

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Val Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  360
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  360

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Glu Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Glu Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  361
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  361

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Arg Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  362
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  362

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  363
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  363

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Asp Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  364
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  364

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  365
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  365

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Arg Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  366
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  366

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  367
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  367

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Gly Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Ser Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  368
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  368

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Val Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Leu Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  369
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  369

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  370
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  370

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  371
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  371

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ser Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly His Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  372
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  372

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Leu Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  373
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  373

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Arg Ala Glu Phe Asn Glu Ser Glu Ser Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  374
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  374

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asn Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  375
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  375

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Ile Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  376
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  376

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr His Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Trp Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  377
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  377

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Arg Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Leu Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  378
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  378

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Met Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  379
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  379

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Ala Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  380
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  380

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Leu Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Arg Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  381
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  381

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Arg Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Gln Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Ser Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  382
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  382

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Leu Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Ser Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  383
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  383

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Leu Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  384
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  384

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Cys Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  385
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  385

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  386
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  386

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ile Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


Asn Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Tyr Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  387
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  387

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Gly Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Glu Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Thr Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  388
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  388

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn Arg Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Glu Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  389
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  389

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Arg Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Cys Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Asn Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  390
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  390

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Gln Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Thr Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Tyr Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  391
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  391

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  392
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  392

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Ser Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  393
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  393

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Tyr Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Met Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Arg Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  394
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  394

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  395
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  395

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  396
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  396

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Arg Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Val Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  397
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  397

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Arg Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  398
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  398

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  399
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  399

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Gln Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  400
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  400

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  401
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  401

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Tyr Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Arg Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Ala Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  402
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  402

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  403
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  403

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Cys Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Arg 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  404
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  404

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Ala Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  405
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  405

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Leu Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Gly Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  406
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  406

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Glu Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ser Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  407
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  407

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  408
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  408

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Cys Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  409
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  409

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


Asn Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Ala Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  410
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  410

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Leu Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  411
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  411

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Ala Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Ala Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr His Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Asn Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  412
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  412

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Cys Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  413
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  413

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  414
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  414

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Gln Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  415
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  415

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Arg Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  416
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  416

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  417
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  417

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Cys Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  418
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  418

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Val Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Val Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  419
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  419

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Arg Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  420
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  420

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Ser Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Gln Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  421
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  421

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Phe Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Gln Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  422
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  422

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Thr 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  423
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  423

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Gln Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  424
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  424

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Gly Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Leu Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Arg Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  425
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  425

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  426
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  426

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  427
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  427

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Tyr Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  428
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  428

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Arg Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  429
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  429

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Pro Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Val Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  430
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  430

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  431
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  431

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Arg 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Ala Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  432
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  432

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Gln Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  433
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  433

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Thr 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  434
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  434

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Ala Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Val Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  435
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  435

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Cys Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Glu Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Arg Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  436
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  436

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Leu Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  437
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  437

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  438
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  438

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  439
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  439

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  440
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  440

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  441
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  441

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  442
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  442

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Glu Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  443
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  443

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  444
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  444

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  445
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  445

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Cys Val Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  446
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  446

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Phe Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  447
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  447

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ser 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Leu Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Ser Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  448
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  448

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Asp Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Arg Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Arg 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  449
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  449

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  450
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  450

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Tyr Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Lys Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  451
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  451

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Pro Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  452
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  452

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Arg Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  453
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  453

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn Arg Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Gly Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  454
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  454

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  455
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  455

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  456
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  456

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn Ala Ile His 
    130                 135                 140                 


Phe Ser Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Thr Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  457
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  457

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  458
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  458

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Arg Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Ser Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  459
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  459

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Ala Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Thr Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Ile Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  460
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  460

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Leu Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Lys Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  461
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  461

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Ala Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  462
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  462

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Thr Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ser Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  463
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  463

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Thr Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Leu Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly His Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  464
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  464

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ser 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  465
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  465

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asn Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Val Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Tyr Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  466
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  466

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  467
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  467

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Tyr Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Ala Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  468
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  468

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Ile Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Arg Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Leu Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  469
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  469

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Thr 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  470
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  470

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Val Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  471
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  471

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Arg 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  472
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  472

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Val Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  473
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  473

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Leu Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Asn Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  474
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  474

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Arg Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Arg Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  475
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  475

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Val Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Ala Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  476
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  476

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Leu Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Glu Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  477
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  477

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Gly Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Arg Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  478
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  478

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Glu Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  479
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  479

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Glu Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Met Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Glu Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  480
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  480

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Thr 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Ser Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Thr Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  481
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  481

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Val Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  482
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  482

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Cys Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  483
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  483

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Phe Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  484
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  484

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Asn Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Tyr Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  485
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  485

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Ser Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  486
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  486

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Leu Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  487
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  487

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Ala Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  488
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  488

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Arg Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Arg Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  489
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  489

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  490
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  490

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Val Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Asp Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  491
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  491

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Ala Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Asn Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  492
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  492

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  493
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  493

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Ser Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  494
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  494

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Asn Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  495
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  495

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Ser Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Cys Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  496
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  496

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Cys Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Ala Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Arg Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  497
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  497

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Gly Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  498
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  498

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  499
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  499

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Ile Ala Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  500
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  500

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Arg Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  501
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  501

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Val Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  502
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  502

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Val Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  503
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  503

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Lys Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Gln Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  504
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  504

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Ala Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  505
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  505

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Val Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Arg Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  506
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  506

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  507
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  507

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Arg Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  508
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  508

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Ser Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  509
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  509

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Val Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  510
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  510

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Glu Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  511
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  511

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  512
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  512

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ile Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Met Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  513
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  513

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Leu Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  514
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  514

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Gly Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  515
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  515

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ile Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Gly Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  516
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  516

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Met Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Glu Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  517
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  517

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Ala Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Glu Leu Leu Leu Tyr Tyr His Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  518
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  518

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn Asn Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Val Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  519
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  519

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  520
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  520

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Gly Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  521
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  521

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ile Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Ile Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Gln Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  522
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  522

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Gln Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Gly Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  523
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  523

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Val Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Asn Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  524
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  524

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Ala Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Ser Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  525
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  525

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Thr 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Glu Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Glu Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  526
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  526

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Leu Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Leu Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Ala Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Thr Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  527
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  527

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  528
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  528

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr His Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  529
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  529

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  530
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  530

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Ser Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Val Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  531
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  531

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn Arg Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Glu Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  532
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  532

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Asn Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  533
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  533

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Glu Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly His Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  534
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  534

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Phe Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Arg Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Leu Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  535
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  535

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Met Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  536
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  536

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Gln Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Arg Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  537
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  537

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Phe Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  538
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  538

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Asp Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Val Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  539
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  539

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Phe Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  540
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  540

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Gln Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  541
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  541

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Arg Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  542
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  542

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn Asn Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Gln Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  543
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  543

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr His Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  544
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  544

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ser Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Ala Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  545
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  545

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  546
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  546

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Ile Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  547
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  547

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  548
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  548

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Asp Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Gln Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  549
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  549

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Thr Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Val Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Arg Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  550
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  550

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Gly Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Cys Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  551
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  551

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Phe Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Ser Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  552
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  552

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Leu Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  553
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  553

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Val Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  554
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  554

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Gln Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Phe Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  555
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  555

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  556
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  556

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn Asn Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  557
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  557

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Arg Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  558
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  558

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Cys Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  559
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  559

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Gln Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  560
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  560

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Val Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Leu Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  561
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  561

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  562
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  562

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Leu Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Thr Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  563
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  563

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  564
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  564

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Met Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  565
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  565

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Ser Cys Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  566
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  566

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Asp Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  567
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  567

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Glu Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Met Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  568
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  568

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Glu Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  569
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  569

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Phe Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Arg Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  570
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  570

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  571
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  571

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  572
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  572

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Leu Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Ile Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  573
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  573

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly His Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  574
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  574

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Ser Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  575
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  575

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Cys Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  576
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  576

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  577
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  577

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Asp Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Ser Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  578
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  578

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Arg Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Asp Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  579
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  579

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Arg 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Leu Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Gln Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  580
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  580

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr His Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  581
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  581

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn Asn Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  582
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  582

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Trp Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  583
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  583

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Arg 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Gln Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


Asn Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  584
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  584

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Arg Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  585
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  585

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Met Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Leu Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Ser Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  586
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  586

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Leu Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  587
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  587

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Val Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Pro Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Thr 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  588
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  588

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Gln Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Arg Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  589
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  589

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Ala Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Cys Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  590
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  590

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  591
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  591

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  592
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  592

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Leu Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  593
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  593

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Val Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Trp Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  594
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  594

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Arg Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Phe Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  595
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  595

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Arg Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  596
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  596

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Gln Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Ile Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Ser Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  597
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  597

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Ile Ile Asn 
    210                 215                 220                 


Leu Trp Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  598
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  598

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Arg Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  599
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  599

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn Arg Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Lys Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  600
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  600

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  601
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  601

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Phe Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  602
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  602

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Cys Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asn Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  603
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  603

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Met Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  604
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  604

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Phe Tyr Glu Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  605
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  605

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Ser Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Arg Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  606
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  606

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ser 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  607
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  607

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Asp Val Gln Ala Asn Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


Asn Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  608
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  608

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Ser Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Arg Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  609
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  609

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Met Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Arg Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Phe Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  610
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  610

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Arg 
65                  70                  75                  80  


Thr Lys Ala Val Met Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Glu Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  611
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  611

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Cys Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  612
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  612

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  613
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  613

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  614
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  614

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  615
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  615

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Val Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Cys Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  616
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  616

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Val Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Arg Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  617
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  617

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Cys Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Ile Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  618
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  618

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  619
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  619

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  620
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  620

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Ala Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  621
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  621

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  622
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  622

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Val Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  623
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  623

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Ser Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Ala Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Ser Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  624
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  624

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Thr 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  625
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  625

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Cys Val Ile Glu Asp Ile Leu Glu Cys Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  626
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  626

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn Asn Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  627
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  627

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Ala Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  628
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  628

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Arg Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  629
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  629

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  630
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  630

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Cys Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Glu Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Arg Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  631
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  631

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Ser Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  632
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  632

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Ser Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  633
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  633

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  634
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  634

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Phe Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  635
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  635

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Thr Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  636
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  636

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  637
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  637

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  638
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  638

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn Arg Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  639
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  639

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Val Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Glu Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Ala Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  640
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  640

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Phe Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  641
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  641

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Leu Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Cys Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  642
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  642

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Gln Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Ile Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Val Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  643
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  643

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  644
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  644

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Phe Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  645
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  645

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Ser Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  646
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  646

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Val Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  647
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  647

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Gly Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Arg 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  648
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  648

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Glu Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  649
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  649

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Thr 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Ser Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Phe Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  650
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  650

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Arg 
65                  70                  75                  80  


Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Cys Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  651
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  651

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  652
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  652

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  653
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  653

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Ser Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Asn Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  654
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  654

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Ala Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Ser Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  655
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  655

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Pro Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  656
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  656

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Ala Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  657
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  657

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  658
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  658

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ser 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  659
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  659

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Thr 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  660
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  660

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  661
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  661

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Leu Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  662
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  662

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  663
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  663

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  664
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  664

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr His Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Phe Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  665
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  665

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Leu Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Lys Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  666
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  666

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Arg Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  667
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  667

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Leu Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Arg Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  668
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  668

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Val Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  669
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  669

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Phe Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Val Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  670
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  670

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Ala Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  671
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  671

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  672
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  672

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Ser Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  673
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  673

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Met Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  674
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  674

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Gln Cys Phe Ala Ile Ile Lys Leu Lys Gln Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  675
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  675

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Tyr Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  676
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  676

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ile Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  677
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  677

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Gln Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Arg Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  678
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  678

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Leu Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  679
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  679

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Leu Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Asn Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  680
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  680

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  681
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  681

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ser Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Thr Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  682
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  682

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Gln Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  683
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  683

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Cys Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  684
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  684

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Ala Glu Gln Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  685
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  685

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Thr Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Glu Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Trp Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  686
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  686

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Phe Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  687
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  687

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Thr Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  688
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  688

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  689
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  689

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Lys Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  690
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  690

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Arg Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Val Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Gln Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  691
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  691

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Arg Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Glu Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  692
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  692

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Gly Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  693
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  693

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  694
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  694

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Ser Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Phe Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Gln Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  695
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  695

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Ala Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Glu Lys Ala Ile His 
    130                 135                 140                 


Phe Ser Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  696
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  696

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  697
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  697

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Arg Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Gly Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  698
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  698

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Leu Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Leu Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Cys Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  699
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  699

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr His Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  700
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  700

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Lys Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Phe Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Glu Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  701
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  701

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Met Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  702
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  702

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Arg Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  703
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  703

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Gln Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  704
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  704

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


Asn Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Arg Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  705
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  705

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Val Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Arg 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Arg Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  706
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  706

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Leu Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Met Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  707
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  707

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Ile Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  708
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  708

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Leu Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Arg Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Gln Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  709
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  709

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Pro Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Cys Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  710
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  710

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Val Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Cys Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  711
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  711

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Asn Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  712
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  712

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Leu Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Arg Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  713
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  713

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Ala Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Leu Pro Pro Val Asp Cys Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  714
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  714

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Cys Ile Val Glu 
                165                 170                 175     


Glu Thr Val His Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  715
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  715

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Thr Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Glu Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Phe Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  716
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  716

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asp 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  717
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  717

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Arg Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Lys Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Lys Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  718
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  718

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  719
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  719

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Ala Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Arg Val Ile Asp 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  720
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  720

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly His Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Arg Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  721
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  721

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ala Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Arg Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  722
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  722

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Cys Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  723
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  723

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Leu Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asn Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Ala Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  724
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  724

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Arg Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Arg Val Ile Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  725
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  725

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Ala 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Glu Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile Gln 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Asp Val Met Asn 
    210                 215                 220                 


Leu Leu Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Arg Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Ile Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  726
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  726

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Ile Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Gln Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Arg Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Asp Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         


<210>  727
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified TdT Sequence

<400>  727

Met Glu Asn Leu Tyr Phe Gln Gly Thr Val Ser Gln Tyr Ala Cys Gln 
1               5                   10                  15      


Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr Asp Ala Phe 
            20                  25                  30          


Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu Gly Pro Cys 
        35                  40                  45              


Leu Ala Phe Arg Arg Ala Ala Ser Leu Leu Lys Ser Leu Pro His Ala 
    50                  55                  60                  


Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu Gly Asp Gln 
65                  70                  75                  80  


Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln Cys Ser Lys 
                85                  90                  95      


Ala Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile Lys Leu Phe 
            100                 105                 110         


Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg 
        115                 120                 125             


Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Lys Ala Ile His 
    130                 135                 140                 


Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp Asp Ile Ser 
145                 150                 155                 160 


Ala Ala Val Cys Lys Ala Glu Ala Asp Ala Ile Gly Arg Ile Val Glu 
                165                 170                 175     


Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr Leu Thr Gly 
            180                 185                 190         


Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp Phe Leu Ile 
        195                 200                 205             


Thr Thr Pro Glu Met Gly Lys Glu Gln Leu Leu Pro Lys Val Ile Asn 
    210                 215                 220                 


Leu Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser 
225                 230                 235                 240 


Thr Phe Asp Lys Leu Arg Leu Pro Cys Arg Lys Phe Glu Ala Met Asp 
                245                 250                 255     


His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys Lys Glu Leu Ala 
            260                 265                 270         


Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg Val Asp Phe Val 
        275                 280                 285             


Met Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu Gly Trp Thr Gly 
    290                 295                 300                 


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala Arg His Glu Arg 
305                 310                 315                 320 


Lys Met Leu Leu Asp Arg His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
                325                 330                 335     


Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala His Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ile Pro Pro Trp Gln Arg Asn Ala 
        355                 360         



<210>  728
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified Sequence

<400>  728

ttttttgact ttttt							15






