                         SEQUENCE LISTING

<110>  Inserm
 
<120>  NEW BIOMARKERS AND BIOTARGETS IN RENAL CELL CARCINOMA

<130>  BIO18474 BIKFALVI / MC

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Arg Gly Phe Thr Trp Leu Arg Tyr Leu Gly Ile Phe Leu Gly 
1               5                   10                  15      


Val Ala Leu Gly Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn 
            20                  25                  30          


Glu Glu Cys Thr Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg 
        35                  40                  45              


Ser Arg Leu Gln Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile 
    50                  55                  60                  


Ser Val Pro Tyr Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu 
65                  70                  75                  80  


Gln Arg Ala Gln Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu 
                85                  90                  95      


Val Ser Leu Ser Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly 
            100                 105                 110         


His Pro Ser Trp Lys Tyr Leu Gln Glu Val Glu Thr Leu Leu Leu Asn 
        115                 120                 125             


Val Gln Gln Gly Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser 
    130                 135                 140                 


Val Leu Ser Leu Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg 
145                 150                 155                 160 


Pro Lys Ala Leu Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr 
                165                 170                 175     


Cys Ser Cys Cys Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu 
            180                 185                 190         


Val Pro Ser Pro Gln Ser Cys Ser Pro Glu Pro Ser Leu Gln Tyr Ala 
        195                 200                 205             


Ala Thr Gln Leu Tyr Pro Pro Pro Pro Trp Ser Pro Ser Ser Pro Pro 
    210                 215                 220                 


His Ser Thr Gly Ser Val Arg Pro Val Arg Ala Gln Gly Glu Gly Leu 
225                 230                 235                 240 


Leu Pro 
        


<210>  2
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Leu Thr Gly Arg Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  3
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Glu Ser Gly Leu Ala Met Trp Pro Ser Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Gly Pro Pro Pro Val Ala Gly Leu Glu Asp Ala Ala Phe 
            20                  25                  30          


Pro His Leu Gly Glu Ser Leu Gln Pro Leu Pro Arg Ala Cys Pro Leu 
        35                  40                  45              


Arg Cys Ser Cys Pro Arg Val Asp Thr Val Asp Cys Asp Gly Leu Asp 
    50                  55                  60                  


Leu Arg Val Phe Pro Asp Asn Ile Thr Arg Ala Ala Gln His Leu Ser 
65                  70                  75                  80  


Leu Gln Asn Asn Gln Leu Gln Glu Leu Pro Tyr Asn Glu Leu Ser Arg 
                85                  90                  95      


Leu Ser Gly Leu Arg Thr Leu Asn Leu His Asn Asn Leu Ile Ser Ser 
            100                 105                 110         


Glu Gly Leu Pro Asp Glu Ala Phe Glu Ser Leu Thr Gln Leu Gln His 
        115                 120                 125             


Leu Cys Val Ala His Asn Lys Leu Ser Val Ala Pro Gln Phe Leu Pro 
    130                 135                 140                 


Arg Ser Leu Arg Val Ala Asp Leu Ala Ala Asn Gln Val Met Glu Ile 
145                 150                 155                 160 


Phe Pro Leu Thr Phe Gly Glu Lys Pro Ala Leu Arg Ser Val Tyr Leu 
                165                 170                 175     


His Asn Asn Gln Leu Ser Asn Ala Gly Leu Pro Pro Asp Ala Phe Arg 
            180                 185                 190         


Gly Ser Glu Ala Ile Ala Thr Leu Ser Leu Ser Asn Asn Gln Leu Ser 
        195                 200                 205             


Tyr Leu Pro Pro Ser Leu Pro Pro Ser Leu Glu Arg Leu His Leu Gln 
    210                 215                 220                 


Asn Asn Leu Ile Ser Lys Val Pro Arg Gly Ala Leu Ser Arg Gln Thr 
225                 230                 235                 240 


Gln Leu Arg Glu Leu Tyr Leu Gln His Asn Gln Leu Thr Asp Ser Gly 
                245                 250                 255     


Leu Asp Ala Thr Thr Phe Ser Lys Leu His Ser Leu Glu Tyr Leu Asp 
            260                 265                 270         


Leu Ser His Asn Gln Leu Thr Thr Val Pro Ala Gly Leu Pro Arg Thr 
        275                 280                 285             


Leu Ala Ile Leu His Leu Gly Arg Asn Arg Ile Arg Gln Val Glu Ala 
    290                 295                 300                 


Ala Arg Leu His Gly Ala Arg Gly Leu Arg Tyr Leu Leu Leu Gln His 
305                 310                 315                 320 


Asn Gln Leu Gly Ser Ser Gly Leu Pro Ala Gly Ala Leu Arg Pro Leu 
                325                 330                 335     


Arg Gly Leu His Thr Leu His Leu Tyr Gly Asn Gly Leu Asp Arg Val 
            340                 345                 350         


Pro Pro Ala Leu Pro Arg Arg Leu Arg Ala Leu Val Leu Pro His Asn 
        355                 360                 365             


His Val Ala Ala Leu Gly Ala Arg Asp Leu Val Ala Thr Pro Gly Leu 
    370                 375                 380                 


Thr Glu Leu Asn Leu Ala Tyr Asn Arg Leu Ala Ser Ala Arg Val His 
385                 390                 395                 400 


His Arg Ala Phe Arg Arg Leu Arg Ala Leu Arg Ser Leu Asp Leu Ala 
                405                 410                 415     


Gly Asn Gln Leu Thr Arg Leu Pro Met Gly Leu Pro Thr Gly Leu Arg 
            420                 425                 430         


Thr Leu Gln Leu Gln Arg Asn Gln Leu Arg Met Leu Glu Pro Glu Pro 
        435                 440                 445             


Leu Ala Gly Leu Asp Gln Leu Arg Glu Leu Ser Leu Ala His Asn Arg 
    450                 455                 460                 


Leu Arg Val Gly Asp Ile Gly Pro Gly Thr Trp His Glu Leu Gln Ala 
465                 470                 475                 480 


Leu Gln Val Arg His Arg Leu Val Ser His Thr Val Pro Arg Ala Pro 
                485                 490                 495     


Pro Ser Pro Cys Leu Pro Cys His Val Pro Asn Ile Leu Val Ser Trp 
            500                 505                 510         


<210>  4
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


