                         SEQUENCE LISTING

<110>  Wings Therapeutics, Inc.
 
<120>  OLIGONUCLEOTIDES FOR USE IN THE TREATMENT OF DYSTROPHIC 
       EPIDERMOLYSIS BULLOSA

<130>  056520-503001WO

<150>  GB 1902735.8
<151>  2019-02-28

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Wild-type pre-mRNA sequence of human COL7A1 exon 105

<400>  1
ggauccccag gaaaggaugg agugccuggu auccgaggag aaaaaggaga uguuggcuuc       60

augggucccc ggggccucaa g                                                 81


<210>  2
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human COL7A1 pre-mRNA fragment including wild-type exon 105

<400>  2
ucucccugcu agggaucccc aggaaaggau ggagugccug guauccgagg agaaaaagga       60

gauguuggcu ucaugggucc ccggggccuc aaggua                                 96


<210>  3
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON UMCG-AON1

<400>  3
gauaccaggc acuccauccu                                                   20


<210>  4
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON UMCG-AON2

<400>  4
caugaagcca acaucuccuu                                                   20


<210>  5
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 1

<400>  5
acaucuccuu uuucuccucg                                                   20


<210>  6
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 1b

<400>  6
uccuuuuucu ccucggauac                                                   20


<210>  7
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 2

<400>  7
ggcacuccau ccuuuccugg                                                   20


<210>  8
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 2b

<400>  8
aggcacucca uccuuuccug                                                   20


<210>  9
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 3

<400>  9
ccaugaagcc aacaucuccu                                                   20


<210>  10
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 4

<400>  10
ggaucccuag cagggaga                                                     18


<210>  11
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 5

<400>  11
uucuuuccua ccuugaggcc                                                   20


<210>  12
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 6

<400>  12
cuuuuucucc ucggauacca                                                   20


<210>  13
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 7

<400>  13
cuccucggau accaggcacu ccau                                              24


<210>  14
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 8

<400>  14
ccgggaccca ugaagccaac aucu                                              24


<210>  15
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 9

<400>  15
ccgggaccca ugaagccaac                                                   20


<210>  16
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 10/35

<400>  16
gacccaugaa gccaacaucu                                                   20


<210>  17
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 11

<400>  17
gggacccaug aagccaacau                                                   20


<210>  18
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 12

<400>  18
cggggaccca ugaagccaac aucu                                              24


<210>  19
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 13

<400>  19
cccgggaccc augaagccaa cauc                                              24


<210>  20
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 14

<400>  20
ccgggaccca ugaagccaac auc                                               23


<210>  21
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 15

<400>  21
cggggaccca ugaagccaac                                                   20


<210>  22
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 16

<400>  22
ccggggaccc augaagccaa                                                   20


<210>  23
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 17

<400>  23
ccgggaccca ugaagccaac au                                                22


<210>  24
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 18

<400>  24
gacccaugaa gccaacaucu ccuu                                              24


<210>  25
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 19

<400>  25
ggccccggga cccaugaagc caac                                              24


<210>  26
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 20

<400>  26
gggacccaug aagccaacau cucc                                              24


<210>  27
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 21

<400>  27
ccaugaagcc aacaucuccu u                                                 21


<210>  28
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 22

<400>  28
cccaugaagc caacaucucc u                                                 21


<210>  29
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 23

<400>  29
acccaugaag ccaacaucuc c                                                 21


<210>  30
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 24

<400>  30
gacccaugaa gccaacaucu c                                                 21


<210>  31
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 25

<400>  31
ggacccauga agccaacauc u                                                 21


<210>  32
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 26

<400>  32
gggacccaug aagccaacau c                                                 21


<210>  33
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 27

<400>  33
cgggacccau gaagccaaca u                                                 21


<210>  34
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 28

<400>  34
ccgggaccca ugaagccaac a                                                 21


<210>  35
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 29

<400>  35
gacccaugaa gccaacaucu cc                                                22


<210>  36
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 30

<400>  36
ggacccauga agccaacauc uc                                                22


<210>  37
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 31

<400>  37
gggacccaug aagccaacau cu                                                22


<210>  38
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 32

<400>  38
ggacccauga agccaacauc ucc                                               23


<210>  39
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 33

<400>  39
gggacccaug aagccaacau cuc                                               23


<210>  40
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 34

<400>  40
cauccuuucc uggggaucc                                                    19


<210>  41
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 36

<400>  41
ggacccauga agccaacauc                                                   20


<210>  42
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 37

<400>  42
ccaugaagcc aacaucucc                                                    19


<210>  43
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 38

<400>  43
cccaugaagc caacaucucc                                                   20


<210>  44
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 39

<400>  44
cuccucggau accaggcacu c                                                 21


<210>  45
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 40

<400>  45
ccaugaagcc aacaucuc                                                     18


<210>  46
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 41

<400>  46
guuucuuucc uaccuugagg                                                   20


<210>  47
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 42

<400>  47
ggacccauga agccaaca                                                     18


<210>  48
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 43

<400>  48
caugaagcca acaucucc                                                     18


<210>  49
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 44

<400>  49
uucuccucgg auaccaggca                                                   20


<210>  50
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 45

<400>  50
ucuccucgga uaccaggcac                                                   20


<210>  51
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 46

<400>  51
ccucggauac caggcacucc                                                   20


<210>  52
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 47

<400>  52
ccaggcacuc cauccuuucc                                                   20


<210>  53
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 48

<400>  53
ggauaccagg cacuccaucc                                                   20


<210>  54
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 49

<400>  54
cuuguuucuu uccuaccuug                                                   20


<210>  55
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 50

<400>  55
uguuucuuuc cuaccuugag                                                   20


<210>  56
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 51

<400>  56
caugaagcca acaucuccu                                                    19


<210>  57
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 52

<400>  57
augaagccaa caucuccuu                                                    19


<210>  58
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 53

<400>  58
ccucggauac caggcacuc                                                    19


<210>  59
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 54

<400>  59
cggauaccag gcacuccauc                                                   20


<210>  60
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON 55

<400>  60
cucggauacc aggcacuc                                                     18


<210>  61
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL7A1 pre-mRNA exon 105 region 1 (E105-R1)

<400>  61
ttggcttcat ggg                                                          13


<210>  62
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AON sequence targeting E105-R1

<400>  62
cccaugaagc caa                                                          13


<210>  63
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA Forward primer; C7-del105 Forward primer

<400>  63
gtgacaaagg acctcgggg                                                    19


<210>  64
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA Reverse primer; C7-del105 Reverse primer

<400>  64
ctccatcaag gccacaggc                                                    19


<210>  65
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GusB Forward primer

<400>  65
gtttttgatc cagacccaga tg                                                22


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GusB Reverse primer

<400>  66
gcccattatt cagagcgagt a                                                 21


<210>  67
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GusB Probe (HEX)

<400>  67
tgcagggttt caccaggatc cac                                               23


<210>  68
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C7 Forward primer

<400>  68
tcggttgctg gaaactgc                                                     18


<210>  69
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C7 Reverse primer

<400>  69
cacaggcagg aagctacc                                                     18


<210>  70
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C7 Probe (FAM)

<400>  70
atcaaggcat ctgccctgcg ggag                                              24


<210>  71
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C7-del105 Probe (FAM)

<400>  71
actccccgtt cacccgggtc ac                                                22


