                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Incorporated
 
<120>  GALECTIN-1/ GALECTIN-3 CHIMERAS AND MULTIVALENT PROTEINS

<130>  U1195.70155WO00

<140>  Not Yet Assigned 
<141>  Concurrently Herewith

<150>  US 62/811,771
<151>  2019-02-28

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Ser Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Val Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Ser Val Ala Phe Asp 
    130                 135 


<210>  2
<211>  408
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (169)..(169)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (402)..(408)
<223>  may or may not be present

<400>  2

Met Ala Ser Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Ser Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Ser Val Ala Phe Asp Gly Ser Gly Gly Gly Ser Gly Gly Ser 
    130                 135                 140                 


Gly Gly Ser Gly Gly Glu Phe Ala Asp Asn Phe Ser Leu His Asp Ala 
145                 150                 155                 160 


Leu Ser Gly Ser Gly Asn Pro Asn Xaa Gln Gly Trp Pro Gly Ala Trp 
                165                 170                 175     


Gly Asn Gln Pro Ala Gly Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro 
            180                 185                 190         


Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala 
        195                 200                 205             


Pro Pro Gly Ala Tyr Pro Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro 
    210                 215                 220                 


Ala Pro Gly Val Tyr Pro Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro 
225                 230                 235                 240 


Ser Ser Gly Gln Pro Ser Ala Pro Gly Ala Tyr Pro Ala Thr Gly Pro 
                245                 250                 255     


Tyr Gly Ala Pro Ala Gly Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu 
            260                 265                 270         


Pro Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val 
        275                 280                 285             


Lys Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp 
    290                 295                 300                 


Val Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val 
305                 310                 315                 320 


Ile Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg 
                325                 330                 335     


Gln Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val 
            340                 345                 350         


Leu Val Glu Pro Asp His Phe Lys Val Ala Val Asn Asp Ala His Leu 
        355                 360                 365             


Leu Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu 
    370                 375                 380                 


Gly Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser Tyr Asn Met Ile 
385                 390                 395                 400 


Leu Glu His His His His His His 
                405             


<210>  3
<211>  460
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (221)..(221)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (454)..(460)
<223>  may or may not be present

<400>  3

Met Ala Ser Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Ser Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Ser Val Ala Phe Asp Gly Ser Gly Gly Gly Ser Gly Gly Ser 
    130                 135                 140                 


Gly Gly Ser Gly Gly Met Ala Arg Met Lys Gln Leu Glu Asp Lys Val 
145                 150                 155                 160 


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
                165                 170                 175     


Leu Lys Lys Leu Val Gly Glu Arg Gly Gly Gly Ser Gly Gly Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Ser Gly Gly Glu Phe Ala Asp Asn Phe Ser 
        195                 200                 205             


Leu His Asp Ala Leu Ser Gly Ser Gly Asn Pro Asn Xaa Gln Gly Trp 
    210                 215                 220                 


Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly Ala Gly Gly Tyr Pro Gly 
225                 230                 235                 240 


Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr 
                245                 250                 255     


Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly Ala Pro Gly Ala Tyr 
            260                 265                 270         


Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro Gly Pro Pro Ser Gly Pro 
        275                 280                 285             


Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser Ala Pro Gly Ala Tyr Pro 
    290                 295                 300                 


Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly Pro Leu Ile Val Pro Tyr 
305                 310                 315                 320 


Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile 
                325                 330                 335     


Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln 
            340                 345                 350         


Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn 
        355                 360                 365             


Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly 
    370                 375                 380                 


Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe 
385                 390                 395                 400 


Lys Ile Gln Val Leu Val Glu Pro Asp His Phe Lys Val Ala Val Asn 
                405                 410                 415     


Asp Ala His Leu Leu Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu 
            420                 425                 430         


Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser 
        435                 440                 445             


Tyr Asn Met Ile Leu Glu His His His His His His 
    450                 455                 460 


<210>  4
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Phe Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly 
1               5                   10                  15      


Asn Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala 
            20                  25                  30          


Gly Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly 
        35                  40                  45              


Gln Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr 
    50                  55                  60                  


Pro Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr 
65                  70                  75                  80  


Pro Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro 
                85                  90                  95      


Ser Ala Pro Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala 
            100                 105                 110         


Gly Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val 
        115                 120                 125             


Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn 
    130                 135                 140                 


Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe 
145                 150                 155                 160 


Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr 
                165                 170                 175     


Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro 
            180                 185                 190         


Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp 
        195                 200                 205             


His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His 
    210                 215                 220                 


Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp 
225                 230                 235                 240 


Ile Asp Leu Thr Ser Ala Ser Tyr Asn Met Ile Leu Glu His His His 
                245                 250                 255     


His His His 
            


<210>  5
<211>  66
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (15)..(49)
<223>  is a dimerization sequence

<400>  5

Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Ala 
1               5                   10                  15      


Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
            20                  25                  30          


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu 
        35                  40                  45              


Arg Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser 
    50                  55                  60                  


Gly Gly 
65      


<210>  6
<211>  1359
<212>  DNA
<213>  Homo sapiens

<400>  6
atggctagtg gtctggtcgc cagcaacctg aatctcaaac ctggagagag ccttcgagtg       60

cgaggcgagg tggctcctga cgctaagagc ttcgtgctga acctgggcaa agacagcaac      120

aacctgtgcc tgcacttcaa ccctcgcttc aacgcccacg gcgacgccaa caccatcgtg      180

tgcaacagca aggacggcgg ggcctggggg accgagcagc gggaggctgt ctttcccttc      240

cagcctggaa gtgttgcaga ggtgagcatc accttcgacc aggccaacct gaccgtcaag      300

ctgccagatg gatacgagtt caagttcccc aaccgcctca acctggaggc catcaactac      360

atggcagctg acggtgactt caagatcaaa agtgtggcct ttgacggatc cggcggcggc      420

agcggcggca gcggcggcag cggcggcatg gcgcgcatga aacagctgga agataaagtg      480

gaagaactgc tgagcaaaaa ctatcatctg gaaaacgaag tggcgcgcct gaaaaaactg      540

gtgggcgaac gcggcggcgg cagcggcggc agcggcggcg gcggcagcgg cggcagcggc      600

gaattcgcag acaatttttc gctccatgat gcgttatctg ggtctggaaa cccaaaccct      660

caaggatggc ctggcgcatg ggggaaccag cctgctgggg cagggggcta cccaggggct      720

tcctatcctg gggcctaccc cgggcaggca cccccagggg cttatcctgg acaggcacct      780

ccaggcgcct accctggagc acctggagct tatcccggag cacctgcacc tggagtctac      840

ccagggccac ccagcggccc tggggcctac ccatcttctg gacagccaag tgcccccgga      900

gcctaccctg ccactggccc ctatggcgcc cctgctgggc cactgattgt gccttataac      960

ctgcctttgc ctgggggagt ggtgcctcgc atgctgataa caattctggg cacggtgaag     1020

cccaatgcaa acagaattgc tttagatttc caaagaggga atgatgttgc cttccacttt     1080

aacccacgct tcaatgagaa caacaggaga gtcattgttt gcaatacaaa gctggataat     1140

aactggggaa gggaagaaag acagtcggtt ttcccatttg aaagtgggaa accattcaaa     1200

atacaagtac tggttgaacc tgaccacttc aaggttgcag tgaatgatgc tcacttgttg     1260

cagtacaatc atcgggttaa aaaactcaat gaaatcagca aactgggaat ttctggtgac     1320

atagacctca ccagtgcttc atataacatg atactcgag                            1359


<210>  7
<211>  405
<212>  DNA
<213>  Homo sapiens

<400>  7
atggctagtg gtctggtcgc cagcaacctg aatctcaaac ctggagagag ccttcgagtg       60

cgaggcgagg tggctcctga cgctaagagc ttcgtgctga acctgggcaa agacagcaac      120

aacctgtgcc tgcacttcaa ccctcgcttc aacgcccacg gcgacgccaa caccatcgtg      180

tgcaacagca aggacggcgg ggcctggggg accgagcagc gggaggctgt ctttcccttc      240

cagcctggaa gtgttgcaga ggtgagcatc accttcgacc aggccaacct gaccgtcaag      300

ctgccagatg gatacgagtt caagttcccc aaccgcctca acctggaggc catcaactac      360

atggcagctg acggtgactt caagatcaaa agtgtggcct ttgac                      405


<210>  8
<211>  747
<212>  DNA
<213>  Homo sapiens

<400>  8
gcagacaatt tttcgctcca tgatgcgtta tctgggtctg gaaacccaaa ccctcaagga       60

tggcctggcg catgggggaa ccagcctgct ggggcagggg gctacccagg ggcttcctat      120

cctggggcct accccgggca ggcaccccca ggggcttatc ctggacaggc acctccaggc      180

gcctaccctg gagcacctgg agcttatccc ggagcacctg cacctggagt ctacccaggg      240

ccacccagcg gccctggggc ctacccatct tctggacagc caagtgcccc cggagcctac      300

cctgccactg gcccctatgg cgcccctgct gggccactga ttgtgcctta taacctgcct      360

ttgcctgggg gagtggtgcc tcgcatgctg ataacaattc tgggcacggt gaagcccaat      420

gcaaacagaa ttgctttaga tttccaaaga gggaatgatg ttgccttcca ctttaaccca      480

cgcttcaatg agaacaacag gagagtcatt gtttgcaata caaagctgga taataactgg      540

ggaagggaag aaagacagtc ggttttccca tttgaaagtg ggaaaccatt caaaatacaa      600

gtactggttg aacctgacca cttcaaggtt gcagtgaatg atgctcactt gttgcagtac      660

aatcatcggg ttaaaaaact caatgaaatc agcaaactgg gaatttctgg tgacatagac      720

ctcaccagtg cttcatataa catgata                                          747


<210>  9
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser 
1               5                   10                  15      


Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val 
            20                  25                  30          


Gly Glu Arg 
        35  


<210>  10
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  


<210>  11
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


