                         SEQUENCE LISTING

<110>  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
       Majzner, Robbie G
       Mackall, Crystal L
       Rietberg, Skyler P
 
<120>  CHIMERIC ANTIGEN RECEPTORS AND THERAPEUTIC USES THEREOF

<130>  078430-510001WO

<140>  Herewith
<141>  Herewith

<150>  US 62/812,105
<151>  2019-02-28

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  FRP5-4D5-41BB-zeta

<400>  1

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser 
65                  70                  75                  80  


Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu Val Tyr His Gly Tyr Val 
        115                 120                 125             


Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
145                 150                 155                 160 


Thr Gln Ser His Lys Phe Leu Ser Thr Ser Val Gly Asp Arg Val Ser 
                165                 170                 175     


Ile Thr Cys Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
        195                 200                 205             


Ser Arg Tyr Thr Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly 
    210                 215                 220                 


Pro Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
225                 230                 235                 240 


Val Tyr Phe Cys Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
        275                 280                 285             


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
    290                 295                 300                 


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
305                 310                 315                 320 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
                325                 330                 335     


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
            340                 345                 350         


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
        355                 360                 365             


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
    370                 375                 380                 


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                405                 410                 415     


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            420                 425                 430         


Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys 
        435                 440                 445             


Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg 
    450                 455                 460                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
465                 470                 475                 480 


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                485                 490                 495     


Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met 
            500                 505                 510         


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        515                 520                 525             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    530                 535                 540                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
545                 550                 555                 560 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
                565                 570                 575     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            580                 585                 590         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        595                 600                 605             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    610                 615                 620                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
625                 630                 635                 640 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                645                 650                 655     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            660                 665                 670         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        675                 680                 685             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    690                 695                 700                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
705                 710                 715                 720 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                725                 730                 735     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745                 750     


<210>  2
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  4D5-FRP5-41BB-zeta

<400>  2

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
                165                 170                 175     


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        275                 280                 285             


Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile 
    290                 295                 300                 


Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp 
305                 310                 315                 320 


Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn 
                325                 330                 335     


Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe 
            340                 345                 350         


Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn 
        355                 360                 365             


Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu 
    370                 375                 380                 


Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr 
385                 390                 395                 400 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Asp Ile Gln Leu Thr Gln Ser His Lys Phe Leu Ser Thr Ser 
            420                 425                 430         


Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Tyr 
        435                 440                 445             


Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
    450                 455                 460                 


Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr Gly Val Pro Ser Arg Phe 
465                 470                 475                 480 


Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr Phe Thr Ile Ser Ser Val 
                485                 490                 495     


Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Phe Arg Thr 
            500                 505                 510         


Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala 
        515                 520                 525             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    530                 535                 540                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
545                 550                 555                 560 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
                565                 570                 575     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            580                 585                 590         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        595                 600                 605             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    610                 615                 620                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
625                 630                 635                 640 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                645                 650                 655     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            660                 665                 670         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        675                 680                 685             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    690                 695                 700                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
705                 710                 715                 720 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                725                 730                 735     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745                 750     


<210>  3
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  HA22-m971-41BB-zeta

<400>  3

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Ala Phe Ser Ile Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu 
    50                  55                  60                  


Lys Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Gly Thr Tyr 
65                  70                  75                  80  


Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg His Ser Gly Tyr Gly Thr His Trp Gly 
        115                 120                 125             


Val Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
        195                 200                 205             


Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
    290                 295                 300                 


Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala 
305                 310                 315                 320 


Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
                325                 330                 335     


Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser 
            340                 345                 350         


Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe 
        355                 360                 365             


Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr 
    370                 375                 380                 


Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp Ile Trp 
385                 390                 395                 400 


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu 
        435                 440                 445             


Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr 
    450                 455                 460                 


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg 
465                 470                 475                 480 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
                485                 490                 495     


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln Thr 
            500                 505                 510         


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr 
        515                 520                 525             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    530                 535                 540                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
545                 550                 555                 560 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                565                 570                 575     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            580                 585                 590         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        595                 600                 605             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    610                 615                 620                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
625                 630                 635                 640 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                645                 650                 655     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            660                 665                 670         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        675                 680                 685             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    690                 695                 700                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
705                 710                 715                 720 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                725                 730                 735     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745             


<210>  4
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  m971-HA22-41BB-zeta

<400>  4

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys 
65                  70                  75                  80  


Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn 
                85                  90                  95      


Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp 
        115                 120                 125             


Leu Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Thr Ile Trp Ser Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly 
            180                 185                 190         


Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Ser Tyr Ser Ile Pro Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu 
                245                 250                 255     


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Ala Phe Ser Ile Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu 
305                 310                 315                 320 


Lys Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Gly Thr Tyr 
                325                 330                 335     


Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
        355                 360                 365             


Ala Met Tyr Tyr Cys Ala Arg His Ser Gly Tyr Gly Thr His Trp Gly 
    370                 375                 380                 


Val Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
        435                 440                 445             


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
    450                 455                 460                 


Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
465                 470                 475                 480 


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
                485                 490                 495     


Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr 
            500                 505                 510         


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr Thr 
        515                 520                 525             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    530                 535                 540                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
545                 550                 555                 560 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                565                 570                 575     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            580                 585                 590         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        595                 600                 605             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    610                 615                 620                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
625                 630                 635                 640 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                645                 650                 655     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            660                 665                 670         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        675                 680                 685             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    690                 695                 700                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
705                 710                 715                 720 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                725                 730                 735     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745             


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  signal peptide

<400>  5

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  6
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  scFv1 of FRP5-4D5-41BB-zeta in SEQ ID NO: 1

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser His Lys Phe 
    130                 135                 140                 


Leu Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
145                 150                 155                 160 


Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln 
    210                 215                 220                 


His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  7
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  scFv1 of 4D5-FRP5-41BB-zeta in SEQ ID NO: 2

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr 
                165                 170                 175     


Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp 
    210                 215                 220                 


Gly Phe Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  8
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  scFv1 of HA22-m971-41BB-zeta in SEQ ID NO: 3

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Gly Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Ser Gly Tyr Gly Thr His Trp Gly Val Leu Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
    130                 135                 140                 


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Ile Leu His 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Phe Ala Thr Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  9
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  scFv1 of m971-HA22-41BB-zeta in SEQ ID NO: 4

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser 
145                 150                 155                 160 


Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu 
                165                 170                 175     


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
            180                 185                 190         


Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
        195                 200                 205             


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro 
    210                 215                 220                 


Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235     


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  Linker

<400>  10

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  11
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  scFv2 of FRP5-4D5-41BB-zeta in SEQ ID NO: 1

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr 
                165                 170                 175     


Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp 
    210                 215                 220                 


Gly Phe Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  12
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  scFv2 of 4D5-FRP5-41BB-zeta in SEQ ID NO: 2

<400>  12

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser His Lys Phe 
    130                 135                 140                 


Leu Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
145                 150                 155                 160 


Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln 
    210                 215                 220                 


His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  13
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  scFv2 of HA22-m971-41BB-zeta in SEQ ID NO: 3

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser 
145                 150                 155                 160 


Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu 
                165                 170                 175     


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
            180                 185                 190         


Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
        195                 200                 205             


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro 
    210                 215                 220                 


Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235     


<210>  14
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  scFv2 of m971-HA22-41BB-zeta in SEQ ID NO: 4

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Gly Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Ser Gly Tyr Gly Thr His Trp Gly Val Leu Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
    130                 135                 140                 


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Ile Leu His 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Phe Ala Thr Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  15
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  Hinge/TM

<400>  15

Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys 
65                  70          


<210>  16
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  4-1BB

<400>  16

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  CD3z

<400>  17

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  18
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  encodes the polypeptide of SEQ ID NO: 1

<400>  18
atgctgctgc tggttacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tccagctcca gcagtctggc cccgaactga agaaacctgg cgagacagtg      120

aagatcagct gcaaggccag cggctacccc ttcaccaact acggcatgaa ctgggttaag      180

caggcccctg gacagggcct gaagtggatg ggatggatca ataccagcac cggcgagagc      240

accttcgccg acgatttcaa gggcagattc gacttcagcc tggaaaccag cgccaacacc      300

gcctacctgc agatcaacaa cctgaagtcc gaggacagcg ccacctactt ttgcgccaga      360

tgggaagtgt accacggcta cgtgccatat tggggccagg gcacaacagt gacagtttct      420

tctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatctga tattcagctg      480

acccagagcc acaagtttct gagcaccagc gtgggcgaca gagtgtccat cacatgcaag      540

gcctctcagg acgtgtacaa cgccgtggcc tggtatcagc aaaagcccgg acagagcccc      600

aagctgctga tctacagcgc cagctctaga tacaccggcg tgccaagcag attcacaggc      660

tctggatctg gccctgactt caccttcaca atcagcagcg tgcaggccga ggacctggcc      720

gtgtatttct gccagcagca cttcagaacc cctttcacct ttggcagcgg caccaagctg      780

gaaatcaaag gtggtggtgg tagtggcggt ggtggatctg gcggcggagg tagcggaggc      840

ggtggttcag atatccagat gacacagtcc cctagcagcc tgtctgcctc cgtgggagat      900

agagtgacaa tcacctgtag agccagccag gatgtgaata ccgctgtcgc ttggtatcaa      960

cagaagcctg gcaaggctcc taaactcctg atctactctg ccagcttcct ggaaagcggc     1020

gtgccctcca gattttctgg cagcagaagc ggcaccgact tcaccctgac catttctagc     1080

ctgcagcctg aggacttcgc cacctattac tgtcagcagc attacaccac acctccaacc     1140

ttcggccagg gaacaaaggt cgagatcaaa ggtggcggcg gaagcggtgg cggtggcagc     1200

ggaggtggtg gctctgaagt tcaactggtt gaatcaggcg gcggactggt gcaacctggc     1260

ggatctctta gactgtcttg tgccgcctcc ggcttcaaca tcaaggacac ctacatccac     1320

tgggtccgac aggccccagg caaaggactt gaatgggtcg ccagaatcta ccccaccaac     1380

ggctacacca gatacgccga tagcgtgaaa ggccggttca ccatcagcgc cgacacaagc     1440

aagaataccg cctatctcca gatgaactct ctgagagccg aggataccgc cgtgtactac     1500

tgtagcagat ggggaggcga cggcttctac gctatggatg tttggggaca gggaaccctg     1560

gtcaccgtgt catctgcggc cgcaaccacg acgccagcgc cgcgaccacc aacaccggcg     1620

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg     1680

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg     1740

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1800

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1860

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1920

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1980

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     2040

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     2100

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     2160

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     2220

gacgcccttc acatgcaggc cctgccccct cgctaa                               2256


<210>  19
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  encodes the polypeptide of SEQ ID NO: 2

<400>  19
atgctgctgc tggttacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

atccccgaca tccagatgac acagagccct agcagcctgt ctgcctctgt gggcgataga      120

gtgaccatca cctgtagagc cagccaggat gtgaataccg ccgtggcctg gtatcagcaa      180

aagcctggaa aggcccctaa gctgctgatc tacagcgcca gctttctgga aagcggcgtg      240

ccaagcagat tcagcggcag cagaagcggc accgatttca ccctgaccat ctctagcctg      300

cagcctgagg acttcgccac ctactactgc cagcagcact acaccacacc tccaaccttt      360

ggccagggca ccaaggtgga aatcaaaggt ggcggaggat ctggcggcgg aggaagcgga      420

ggcggcggat ctgaagttca actggttgaa tctggcggag gcctggtgca acctggtgga      480

tctctgagac tgtcttgtgc cgccagcggc ttcaacatca aggacaccta catccactgg      540

gtccgacagg cccctggaaa aggactggaa tgggtcgcca gaatctaccc caccaacggc      600

tacaccagat acgccgatag cgtgaagggc agattcacca tcagcgccga caccagcaag      660

aacaccgcct acctgcagat gaacagcctg agagccgagg acaccgccgt gtactactgt      720

tctagatggg gaggcgacgg cttctacgct atggatgttt ggggccaggg aaccctggtt      780

acagtttcta gtggcggtgg tggtagtggc ggaggcggtt caggtggtgg cggatcaggc      840

ggaggtggca gtcaggttca actgcagcaa tctggccccg agctgaagaa acctggcgag      900

acagtgaaga tcagctgcaa ggcctctggc taccccttca ccaactacgg catgaactgg      960

gttaagcagg ccccaggaca gggcctgaag tggatgggat ggatcaatac cagcaccggc     1020

gagagcacct tcgccgacga tttcaaggga agattcgact tctccctgga aacctccgcc     1080

aatactgcct atctccagat caacaatctg aagtccgagg acagcgctac ctacttctgc     1140

gccagatggg aagtgtacca cggctatgtg ccttactggg gacagggcac aaccgtgaca     1200

gtttctagcg gaggcggagg ctcaggcgga ggcggctctg gtggcggagg ctctgatatt     1260

cagctgaccc agagccacaa gtttctgagc acaagcgtgg gagacagagt cagcatcaca     1320

tgcaaggcta gccaggacgt gtacaacgct gtcgcttggt atcaacagaa gcccggccag     1380

tctccaaaac tgctcatcta ctccgccagc agccggtaca caggcgtgcc atctagattc     1440

acaggctctg gcagcggccc tgacttcacc tttacaatca gcagcgtgca ggccgaggac     1500

ctggccgtgt atttctgtca gcagcatttc agaacccctt tcaccttcgg cagcggaacg     1560

aagctcgaaa tcaaagcggc cgcaaccacg acgccagcgc cgcgaccacc aacaccggcg     1620

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg     1680

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg     1740

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1800

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1860

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1920

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1980

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     2040

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     2100

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     2160

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     2220

gacgcccttc acatgcaggc cctgccccct cgctaa                               2256


<210>  20
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  encodes the polypeptide of SEQ ID NO: 3

<400>  20
atgctgctgc tggttacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctgagg tgcagctggt ggaatctggc ggcggacttg tgaaacctgg cggctctctg      120

aaactgtctt gtgccgccag cggcttcgcc ttcagcatct acgatatgag ctgggtccga      180

cagacccctg agaagagact ggaatgggtc gcctacatca gcagcggcgg aggcacctac      240

tatcccgata cagtgaaggg cagattcacc atcagccggg acaacgccaa gaacaccctg      300

tacctgcaga tgagcagcct gaagtccgag gacaccgcca tgtactactg tgccagacac      360

agcggctatg gcacacactg gggagtgctg tttgcctatt ggggccaggg cacactggtt      420

acagtttctg caggcggagg tggaagcgga ggcggaggaa gtggtggcgg aggttctgat      480

atccagatga cccagaccac cagcagcctg tctgcctctc tgggcgatag agtgaccatc      540

agctgtagag ccagccagga catcagcaac tacctgaact ggtatcagca aaagcccgac      600

ggcaccgtga agctgctgat ctactacacc agcatcctgc acagcggcgt gccaagcaga      660

ttttctggca gcggcagcgg aaccgactac agcctgacaa tcagcaacct ggaacaagag      720

gacttcgcta cctacttctg ccagcaaggc aacaccctgc cttggacatt tggaggcggc      780

accaagctgg aaatcaaagg tggcggtggc tcaggcggtg gcggatcagg cggcggagga      840

tctggcggag gcggttctca agttcagctg cagcaatctg gccctggcct ggtcaaacct      900

agccagacac tgagcctgac atgcgccatc agcggcgata gcgtgtcatc taatagcgcc      960

gcctggaact ggatcagaca gagcccttct agaggcctgg aatggctggg cagaacctac     1020

taccggtcca agtggtacaa cgactacgcc gtgtccgtga agtcccggat caccatcaat     1080

cccgacacca gcaagaacca gttctccctg cagctcaaca gcgtgacacc tgaggataca     1140

gccgtgtact attgcgccag ggaagtgacc ggcgacctgg aagatgcctt tgatatctgg     1200

ggacagggaa caatggtcac cgttagtagt ggcggcggtg gcagcgacat tcagatgaca     1260

cagagcccat cttctctgag cgccagcgtg ggagacagag tgacaatcac atgccgggcc     1320

agccagacca tctggtccta tctcaattgg tatcaacaga ggcccggcaa ggcccctaat     1380

ctcctgatct atgctgcctc tagcctgcag tctggcgtgc catctagatt ctctggaaga     1440

ggctccggca ccgacttcac cctgactatt agttcactgc aggccgagga ttttgccacc     1500

tactactgtc agcagagcta cagcatccct cagaccttcg gccaggggac aaagcttgag     1560

atcaaagcgg ccgcaaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc     1620

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg     1680

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact     1740

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     1800

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1860

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1920

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1980

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     2040

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     2100

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     2160

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     2220

cacatgcagg ccctgccccc tcgctaa                                         2247


<210>  21
<211>  2295
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  encodes the polypeptide of SEQ ID NO: 4

<400>  21
atgctgctgc tggttacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tccagctcca gcagtctggc cctggacttg tgaagcctag ccagacactg      120

agcctgacat gtgccatcag cggcgacagc gtgtcatcta attctgccgc ctggaactgg      180

atcagacaga gcccttctag aggcctggaa tggctgggca gaacctacta ccggtccaag      240

tggtacaacg actacgccgt gtccgtgaag tcccggatca ccatcaatcc cgacaccagc      300

aagaaccagt tctccctgca gctgaacagc gtgacccctg aggataccgc cgtgtactac      360

tgtgccagag aagtgaccgg cgacctggaa gatgccttcg atatctgggg ccagggcaca      420

atggttaccg tttcttctgg cggcggaggc agcgacatcc agatgacaca aagcccaagc      480

agcctgagcg cctctgtggg cgatagagtg accatcacat gtcgggccag ccagaccatc      540

tggtcctacc tgaattggta tcagcagagg cccggcaagg cccctaatct gctgatctat      600

gctgcctcta gcctgcagag cggcgtgcca tctagatttt ctggcagagg cagcggcacc      660

gacttcaccc tgacaattag tagtctgcag gccgaggact tcgccaccta ctactgtcag      720

cagagctaca gcatccctca gaccttcgga cagggcacca agctggaaat caaaggtggc      780

ggaggatctg gcggaggtgg aagcggaggc ggtggtagtg gcggtggtgg atctgaagtg      840

cagcttgttg aatccggcgg aggactcgtg aaacctggcg gatctctgaa actgtcttgc      900

gccgccagcg gcttcgcctt cagcatctat gatatgtctt gggtccgaca gaccccagag      960

aagagactgg aatgggtcgc ctacatcagc tcaggcggcg gaacatatta ccccgacacc     1020

gtgaagggca gattcaccat ctccagagac aacgccaaga acaccctgta cctgcagatg     1080

tccagcctga aaagcgagga cacagccatg tactattgcg ccaggcacag cggctatggc     1140

acacactggg gagtgctgtt tgcctactgg ggacagggaa ccctggttac agtttctgca     1200

ggcggaggcg gttctggtgg tggtggttct ggcggtggcg gtagtgatat tcagatgacc     1260

cagaccacca gcagcctgtc tgctagtctg ggagacagag tgacaatctc ttgcagagcc     1320

agccaggaca tcagcaacta tctcaactgg tatcaacaga aacccgacgg cacagtgaag     1380

ctgctcatct actacaccag catcctgcac tctggcgtgc caagcagatt ttccggctct     1440

ggctctggca ccgattacag cctgaccatc agcaatctgg aacaagagga ttttgctacc     1500

tacttctgcc agcaaggcaa caccctgcct tggacatttg gaggcggaac aaagcttgag     1560

atcaaggcca agaccacacc tcctagcgtg tacggaagag tgaaggaccc caaagcggcc     1620

gcaaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1680

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1740

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1800

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1860

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1920

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1980

gacgcccccg cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga     2040

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     2100

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     2160

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     2220

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     2280

ctgccccctc gctaa                                                      2295


