                         SEQUENCE LISTING

<110>  Jiang, Jean
       Riquelme, Manuel
       Gu, Sumin
 
<120>  Compositions for Treating Osteosarcoma and Methods of Use

<130>  21105.0070P1

<150>  US 62/811,938
<151>  2019-08-28

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Phe Leu Ser Arg Pro Thr Glu Lys Thr Ile 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Lys Arg Asp Pro Cys Pro His Gln Val Asp 
1               5                   10  


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Leu Ser Ala Val Tyr Thr Cys Lys Arg 
1               5                   


<210>  4
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
ggctacacct tcaccagcta ctat                                              24


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
attaatccta gcaatggtgg tact                                              24


<210>  6
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
acaagagagg gtaaccccta ctatactatg aactac                                 36


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Ile Asn Pro Ser Asn Gly Gly Thr 
1               5               


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Thr Arg Glu Gly Asn Pro Tyr Tyr Thr Met Asn Tyr 
1               5                   10          


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
ggctacatct tcaccaccta ctgg                                              24


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
attagtccta gcaacggtcg ttct                                              24


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
gcacgattcg acgaggggga cttc                                              24


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Gly Tyr Ile Phe Ile Thr Tyr Trp 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14

Ile Ser Pro Ser Asn Gly Arg Ser 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15

Ala Arg Phe Asp Glu Gly Asp Phe 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16

Gly Tyr Ile Phe Ile Thr Thr Trp 
1               5               


<210>  17
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
cagagtctgt taaacagtgg aaatcaaaag acctac                                 36


<210>  18
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
ggggcatcc                                                                9


<210>  19
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
cagaatgatc atagttatcc attcacg                                           27


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Thr Tyr 
1               5                   10          


<210>  21
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21

Gly Ala Ser 
1           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Gln Asn Asp Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23

Gln Asn Asp His Ser Tyr Pro Phe Thr 
1               5                   


<210>  24
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24
aaaagtgtca gtacatctgg ctatagttat                                        30


<210>  25
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25
cttgtatcc                                                                9


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26
cagcacatta gggagcttac acg                                               23


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  28
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28

Leu Val Ser 
1           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29

Gln His Ile Arg Glu Leu Thr 
1               5           


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30
aaaagtgtca gtacatctgg ctatagttat                                        30


<210>  31
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31
cttgtatcc                                                                9


<210>  32
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32
cagcacatta gggagcttac acgt                                              24


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  34
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

Leu Val Ser 
1           


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35

Gln His Ile Arg Glu Leu Thr Arg 
1               5               


<210>  36
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36
gagcctctta gaaagcgatg gaaagacata t                                      31


<210>  37
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37
ctggtgtct                                                                9


<210>  38
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38
tggcaaggta cacattttcc gtggacg                                           27


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

Gln Ser Leu Leu Glu Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  40
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40

Leu Val Ser 
1           


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41

Trp Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  42
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42
gaggtccaac tccagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta caccttcacc agctactata tgtactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggggga attaatccta gcaatggtgg tactaacttc      180

aatgagaagt tcaagaacaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtac aagagagggt      300

aacccctact atactatgaa ctactggggt caaggaacct cagtcaccgt ctcctca         357


<210>  43
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43
gaggtccaac tccagcaacc tggggctgaa ctggtgaggc ctggggcttc agtaatgctg       60

tcctgcaagg cttctggcta catcttcacc acctactgga tgcactggct gaagcagagg      120

cctggacaag gccttgactg gattggagag attagtccta gcaacggtcg ttctaattac      180

aataagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtgc acgattcgac      300

gagggggact tctggggcca aggcaccact ctcatagtct cctca                      345


<210>  44
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44
gacattgtga tgacgcagtc tccatcctcc ctgagtgtgt cagcaggaga gaaggtcact       60

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagac ctacttggcc      120

tggtaccagc agaaaccagg gcagcctcct aaactgttga tctacggggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tcatagttat      300

ccattcacgt tcggctcggg gacaaagttg gaaataaaa                             339


<210>  45
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45
gacattgtgt tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcataca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggaac      120

caacagaaac caggacagcc acccagactc ctcatctatc ttgtatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acattaggga gcttacacgt      300

tcggaggggg gaccaagctg gaaatcaaac                                       330


<210>  46
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46
gatattgtga tgacccagtc tcccgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcataca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggaac      120

caacagaaac caggacagcc acccagactc ctcatctatc ttgtatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acattaggga gcttacacgt      300

tcggaggggg ggaccaagct ggaaatcaaa                                       330


<210>  47
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47
gacgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gaaagcgatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  48
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48

Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Asn Pro Tyr Tyr Thr Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  49
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49

Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Met Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser Pro Ser Asn Gly Arg Ser Asn Tyr Asn Lys Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Glu Gly Asp Phe Trp Gly Gln Gly Thr Thr Leu Ile 
            100                 105                 110         


Val Ser 
        


<210>  50
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn Asp 
                85                  90                  95      


His Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp 
            100                 105         


<210>  52
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  53
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  54
<211>  384
<212>  DNA
<213>  Mus musculus

<400>  54
gaggttcagc tggagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta caccttcacc agctactata tgtactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggggga attaatccta gcaatggtgg tactaacttc      180

aatgagaagt tcaagaacaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtac aagagagggt      300

aacccctact atactatgaa ctactggggt caaggaacct cagtcaccgt ctcctcagcc      360

aaaacgacac ccccatctgt ctat                                             384


<210>  55
<211>  128
<212>  PRT
<213>  Mus musculus

<400>  55

Glu Val Gln Leu Glu Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Asn Pro Tyr Tyr Thr Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 125             


<210>  56
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  56

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser 
        115                 120         


<210>  57
<211>  375
<212>  DNA
<213>  Mus musculus

<400>  57
gatattgtga tgacccagac tccatcctcc ctgagtgtgt cagcaggaga gaaggtcact       60

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagac ctacttggcc      120

tggtaccagc agaaaccagg gcagcctcct aaactgttga tctacggggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tcatagttat      300

ccattcacgt tcggctcggg gacaaagttg gaaataaaac gggctgatgc tgcaccaact      360

gtatccgcat gcacc                                                       375


<210>  58
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  58

Gln Ser Leu Leu Asn Ser 
1               5       


<210>  59
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  59

Pro Lys Leu Leu Ile Tyr Gly 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  60

Val Tyr Tyr Cys Gln Asn Asp 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61

Tyr Thr Phe Thr Ser Tyr Tyr 
1               5           


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62

Asn Pro Ser Asn Gly 
1               5   


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  63

Tyr Cys Thr Arg Glu Gly Asn Pro 
1               5               


