                         SEQUENCE LISTING

<110>  Icahn School of Medicine at Mount Sinai
 
<120>  TREATMENT OF PULMONARY FIBROSIS WITH SERCA2a GENE THERAPY

<130>  27527-0168WO1

<150>  US 62/811,384
<151>  2019-02-27

<150>  US 62/815,220
<151>  2019-03-07

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  1

Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys Ile Glu Arg Ala Asn 
1               5                   10                  15      


Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys Lys Glu Phe Thr Leu 
            20                  25                  30          


Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val Tyr Cys Thr Pro Asn 
        35                  40                  45              


Lys Pro Ser Arg Thr Ser Met Ser 
    50                  55      


<210>  2
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Gly Lys Glu Cys Val Gln Pro  Ala Thr Lys Ser Cys  Ser Phe Ser 
        995                 1000                 1005             


Ala Cys  Thr Asp Gly Ile Ser  Trp Pro Phe Val Leu  Leu Ile Met 
    1010                 1015                 1020             


Pro Leu  Val Ile Trp Val Tyr  Ser Thr Asp Thr Asn  Phe Ser Asp 
    1025                 1030                 1035             


Met Phe  Trp Ser 
    1040         


<210>  3
<211>  997
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Ala Ile Leu Glu 
        995         


<210>  4
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Gly Lys Glu Cys Val Gln Pro  Ala Thr Lys Ser Cys  Ser Phe Ser 
        995                 1000                 1005             


Ala Cys  Thr Asp Gly Ile Ser  Trp Pro Phe Val Leu  Leu Ile Met 
    1010                 1015                 1020             


Pro Leu  Val Ile Trp Val Tyr  Ser Thr Asp Thr Asn  Phe Ser Asp 
    1025                 1030                 1035             


Met Phe  Trp Ser 
    1040         


<210>  5
<211>  73
<212>  PRT
<213>  Mus musculus

<400>  5

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe 
65                  70              


<210>  6
<211>  998
<212>  PRT
<213>  Mus musculus

<400>  6

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Lys Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Ser Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val Gln Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Lys Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Ser Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Asp Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Gln Pro Ala Ile Leu Glu 
        995             


<210>  7
<211>  571
<212>  PRT
<213>  Mus musculus

<400>  7

Val Ile Lys Gln Leu Met Lys Lys Glu Phe Thr Leu Glu Phe Ser Arg 
1               5                   10                  15      


Asp Arg Lys Ser Met Ser Val Tyr Cys Thr Pro Asn Lys Pro Ser Arg 
            20                  25                  30          


Thr Ser Met Ser Lys Met Phe Val Lys Gly Ala Pro Glu Gly Val Ile 
        35                  40                  45              


Asp Arg Cys Thr His Ile Arg Val Gly Ser Thr Lys Val Pro Met Thr 
    50                  55                  60                  


Pro Gly Val Lys Gln Lys Ile Met Ser Val Ile Arg Glu Trp Gly Ser 
65                  70                  75                  80  


Gly Ser Asp Thr Leu Arg Cys Leu Ala Leu Ala Thr His Asp Asn Pro 
                85                  90                  95      


Leu Lys Arg Glu Glu Met His Leu Glu Asp Ser Ala Asn Phe Ile Lys 
            100                 105                 110         


Tyr Glu Thr Asn Leu Thr Phe Val Gly Cys Val Gly Met Leu Asp Pro 
        115                 120                 125             


Pro Arg Ile Glu Val Ala Ser Ser Val Lys Leu Cys Arg Gln Ala Gly 
    130                 135                 140                 


Ile Arg Val Ile Met Ile Thr Gly Asp Asn Lys Gly Thr Ala Val Ala 
145                 150                 155                 160 


Ile Cys Arg Arg Ile Gly Ile Phe Gly Gln Asp Glu Asp Val Thr Ser 
                165                 170                 175     


Lys Ala Phe Thr Gly Arg Glu Phe Asp Glu Leu Ser Pro Ser Ala Gln 
            180                 185                 190         


Arg Asp Ala Cys Leu Asn Ala Arg Cys Phe Ala Arg Val Glu Pro Ser 
        195                 200                 205             


His Lys Ser Lys Ile Val Glu Phe Leu Gln Ser Phe Asp Glu Ile Thr 
    210                 215                 220                 


Ala Met Thr Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys Lys Ser 
225                 230                 235                 240 


Glu Ile Gly Ile Ala Met Gly Ser Gly Thr Ala Val Ala Lys Thr Ala 
                245                 250                 255     


Ser Glu Met Val Leu Ala Asp Asp Asn Phe Ser Thr Ile Val Ala Ala 
            260                 265                 270         


Val Glu Glu Gly Arg Ala Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg 
        275                 280                 285             


Tyr Leu Ile Ser Ser Asn Val Gly Glu Val Val Cys Ile Phe Leu Thr 
    290                 295                 300                 


Ala Ala Leu Gly Phe Pro Glu Ala Leu Ile Pro Val Gln Leu Leu Trp 
305                 310                 315                 320 


Val Asn Leu Val Thr Asp Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn 
                325                 330                 335     


Pro Pro Asp Leu Asp Ile Met Asn Lys Pro Pro Arg Asn Pro Lys Glu 
            340                 345                 350         


Pro Leu Ile Ser Gly Trp Leu Phe Phe Arg Tyr Leu Ala Ile Gly Cys 
        355                 360                 365             


Tyr Val Gly Ala Ala Thr Val Gly Ala Ala Ala Trp Trp Phe Ile Ala 
    370                 375                 380                 


Ala Asp Gly Gly Pro Arg Val Ser Phe Tyr Gln Leu Ser His Phe Leu 
385                 390                 395                 400 


Gln Cys Lys Glu Asp Asn Pro Asp Phe Asp Gly Val Asp Cys Ala Ile 
                405                 410                 415     


Phe Glu Ser Pro Tyr Pro Met Thr Met Ala Leu Ser Val Leu Val Thr 
            420                 425                 430         


Ile Glu Met Cys Asn Ala Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu 
        435                 440                 445             


Leu Arg Met Pro Pro Trp Glu Asn Ile Trp Leu Val Gly Ser Ile Cys 
    450                 455                 460                 


Leu Ser Met Ser Leu His Phe Leu Ile Leu Tyr Val Glu Pro Leu Pro 
465                 470                 475                 480 


Leu Ile Phe Gln Ile Thr Pro Leu Asn Leu Thr Gln Trp Leu Met Val 
                485                 490                 495     


Leu Lys Ile Ser Leu Pro Val Ile Leu Met Asp Glu Thr Leu Lys Phe 
            500                 505                 510         


Val Ala Arg Asn Tyr Leu Glu Gln Pro Gly Lys Glu Cys Val Gln Pro 
        515                 520                 525             


Ala Thr Lys Ser Ser Cys Ser Leu Ser Ala Cys Thr Asp Gly Ile Ser 
    530                 535                 540                 


Trp Pro Phe Val Leu Leu Ile Met Pro Leu Val Val Trp Val Tyr Ser 
545                 550                 555                 560 


Thr Asp Thr Asn Phe Ser Asp Met Phe Trp Ser 
                565                 570     


<210>  8
<211>  525
<212>  PRT
<213>  Mus musculus

<400>  8

Val Ile Lys Gln Leu Met Lys Lys Glu Phe Thr Leu Glu Phe Ser Arg 
1               5                   10                  15      


Asp Arg Lys Ser Met Ser Val Tyr Cys Thr Pro Asn Lys Pro Ser Arg 
            20                  25                  30          


Thr Ser Met Ser Lys Met Phe Val Lys Gly Ala Pro Glu Gly Val Ile 
        35                  40                  45              


Asp Arg Cys Thr His Ile Arg Val Gly Ser Thr Lys Val Pro Met Thr 
    50                  55                  60                  


Pro Gly Val Lys Gln Lys Ile Met Ser Val Ile Arg Glu Trp Gly Ser 
65                  70                  75                  80  


Gly Ser Asp Thr Leu Arg Cys Leu Ala Leu Ala Thr His Asp Asn Pro 
                85                  90                  95      


Leu Lys Arg Glu Glu Met His Leu Glu Asp Ser Ala Asn Phe Ile Lys 
            100                 105                 110         


Tyr Glu Thr Asn Leu Thr Phe Val Gly Cys Val Gly Met Leu Asp Pro 
        115                 120                 125             


Pro Arg Ile Glu Val Ala Ser Ser Val Lys Leu Cys Arg Gln Ala Gly 
    130                 135                 140                 


Ile Arg Val Ile Met Ile Thr Gly Asp Asn Lys Gly Thr Ala Val Ala 
145                 150                 155                 160 


Ile Cys Arg Arg Ile Gly Ile Phe Gly Gln Asp Glu Asp Val Thr Ser 
                165                 170                 175     


Lys Ala Phe Thr Gly Arg Glu Phe Asp Glu Leu Ser Pro Ser Ala Gln 
            180                 185                 190         


Arg Asp Ala Cys Leu Asn Ala Arg Cys Phe Ala Arg Val Glu Pro Ser 
        195                 200                 205             


His Lys Ser Lys Ile Val Glu Phe Leu Gln Ser Phe Asp Glu Ile Thr 
    210                 215                 220                 


Ala Met Thr Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys Lys Ser 
225                 230                 235                 240 


Glu Ile Gly Ile Ala Met Gly Ser Gly Thr Ala Val Ala Lys Thr Ala 
                245                 250                 255     


Ser Glu Met Val Leu Ala Asp Asp Asn Phe Ser Thr Ile Val Ala Ala 
            260                 265                 270         


Val Glu Glu Gly Arg Ala Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg 
        275                 280                 285             


Tyr Leu Ile Ser Ser Asn Val Gly Glu Val Val Cys Ile Phe Leu Thr 
    290                 295                 300                 


Ala Ala Leu Gly Phe Pro Glu Ala Leu Ile Pro Val Gln Leu Leu Trp 
305                 310                 315                 320 


Val Asn Leu Val Thr Asp Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn 
                325                 330                 335     


Pro Pro Asp Leu Asp Ile Met Asn Lys Pro Pro Arg Asn Pro Lys Glu 
            340                 345                 350         


Pro Leu Ile Ser Gly Trp Leu Phe Phe Arg Tyr Leu Ala Ile Gly Cys 
        355                 360                 365             


Tyr Val Gly Ala Ala Thr Val Gly Ala Ala Ala Trp Trp Phe Ile Ala 
    370                 375                 380                 


Ala Asp Gly Gly Pro Arg Val Ser Phe Tyr Gln Leu Ser His Phe Leu 
385                 390                 395                 400 


Gln Cys Lys Glu Asp Asn Pro Asp Phe Asp Gly Val Asp Cys Ala Ile 
                405                 410                 415     


Phe Glu Ser Pro Tyr Pro Met Thr Met Ala Leu Ser Val Leu Val Thr 
            420                 425                 430         


Ile Glu Met Cys Asn Ala Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu 
        435                 440                 445             


Leu Arg Met Pro Pro Trp Glu Asn Ile Trp Leu Val Gly Ser Ile Cys 
    450                 455                 460                 


Leu Ser Met Ser Leu His Phe Leu Ile Leu Tyr Val Glu Pro Leu Pro 
465                 470                 475                 480 


Leu Ile Phe Gln Ile Thr Pro Leu Asn Leu Thr Gln Trp Leu Met Val 
                485                 490                 495     


Leu Lys Ile Ser Leu Pro Val Ile Leu Met Asp Glu Thr Leu Lys Phe 
            500                 505                 510         


Val Ala Arg Asn Tyr Leu Glu Gln Pro Ala Ile Leu Glu 
        515                 520                 525 


<210>  9
<211>  1044
<212>  PRT
<213>  Mus musculus

<400>  9

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Lys Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Ser Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val Gln Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Lys Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Ser Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Asp Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Gln Pro Gly Lys Glu Cys Val Gln  Pro Ala Thr Lys Ser  Ser Cys Ser 
        995                 1000                 1005             


Leu Ser  Ala Cys Thr Asp Gly  Ile Ser Trp Pro Phe  Val Leu Leu 
    1010                 1015                 1020             


Ile Met  Pro Leu Val Val Trp  Val Tyr Ser Thr Asp  Thr Asn Phe 
    1025                 1030                 1035             


Ser Asp  Met Phe Trp Ser 
    1040                 


<210>  10
<211>  998
<212>  PRT
<213>  Mus musculus

<400>  10

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Lys Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Ser Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val Gln Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Lys Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Ser Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Asp Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Gln Pro Ala Ile Leu Glu 
        995             


<210>  11
<211>  1044
<212>  PRT
<213>  Mus musculus

<400>  11

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Lys Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Ser Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val Gln Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Lys Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Ser Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Asp Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Gln Pro Gly Lys Glu Cys Val Gln  Pro Ala Thr Lys Ser  Ser Cys Ser 
        995                 1000                 1005             


Leu Ser  Ala Cys Thr Asp Gly  Ile Ser Trp Pro Phe  Val Leu Leu 
    1010                 1015                 1020             


Ile Met  Pro Leu Val Val Trp  Val Tyr Ser Thr Asp  Thr Asn Phe 
    1025                 1030                 1035             


Ser Asp  Met Phe Trp Ser 
    1040                 


<210>  12
<211>  1044
<212>  PRT
<213>  Mus musculus

<400>  12

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Lys Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Ser Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val Gln Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Lys Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Ser Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Asp Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Gln Pro Gly Lys Glu Cys Val Gln  Pro Ala Thr Lys Ser  Ser Cys Ser 
        995                 1000                 1005             


Leu Ser  Ala Cys Thr Asp Gly  Ile Ser Trp Pro Phe  Val Leu Leu 
    1010                 1015                 1020             


Ile Met  Pro Leu Val Val Trp  Val Tyr Ser Thr Asp  Thr Asn Phe 
    1025                 1030                 1035             


Ser Asp  Met Phe Trp Ser 
    1040                 


<210>  13
<211>  996
<212>  PRT
<213>  Danio rerio

<400>  13

Met Glu Asn Ala His Thr Lys Ser Val Glu Glu Val Tyr Ser Asn Phe 
1               5                   10                  15      


Ser Val Asn Glu Ser Thr Gly Leu Thr Leu Asp Gln Val Lys Arg Asn 
            20                  25                  30          


Arg Asp Lys Trp Gly Pro Asn Glu Leu Pro Ala Glu Glu Gly Lys Ser 
        35                  40                  45              


Ile Trp Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Ile Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Ile Ser Ala Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Ile Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Ala 
225                 230                 235                 240 


Ser Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Ile Asp Lys Ala Glu Gly Glu Asn Cys Ser Leu Thr Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Ser Thr Tyr Ala Pro Glu Gly Asp Val Cys Leu Asp Asn Arg 
385                 390                 395                 400 


Ile Val Lys Cys Ser Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ser Leu Asp Phe Asn Glu Ser Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Val Arg Asn Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ala Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Ser Pro Asn Lys Ala Lys Ser Ser Ser Ser Lys Met Phe Val 
            500                 505                 510         


Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Ala Tyr Val Arg Val 
        515                 520                 525             


Gly Gly Ser Lys Val Pro Leu Thr Gln Gly Ile Lys Asp Lys Ile Met 
    530                 535                 540                 


Ser Val Ile Arg Glu Tyr Gly Thr Gly Arg Asp Thr Leu Arg Cys Leu 
545                 550                 555                 560 


Ala Leu Ala Thr Arg Asp Asn Pro Leu Lys Lys Glu Glu Met Val Leu 
                565                 570                 575     


Ser Asp Thr Ala Arg Phe Ala Asp Tyr Glu Ser Asp Leu Thr Phe Val 
            580                 585                 590         


Gly Cys Val Gly Met Leu Asp Pro Pro Arg Thr Glu Val Ala Ala Ser 
        595                 600                 605             


Ile Lys Leu Cys Arg His Ala Gly Ile Arg Val Ile Met Ile Thr Gly 
    610                 615                 620                 


Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile Phe 
625                 630                 635                 640 


Ser Asp Asp Asp Asp Val His Arg Met Ala Phe Thr Gly Arg Glu Phe 
                645                 650                 655     


Asp Asp Leu Ser Pro His Ala Gln Arg Glu Ala Val Thr Val Ala Arg 
            660                 665                 670         


Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu Phe 
        675                 680                 685             


Leu Gln Gly Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val Asn 
    690                 695                 700                 


Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly Ser 
705                 710                 715                 720 


Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp Asp 
                725                 730                 735     


Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile Tyr 
            740                 745                 750         


Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val Gly 
        755                 760                 765             


Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu Ala 
    770                 775                 780                 


Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly Leu 
785                 790                 795                 800 


Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met Asn 
                805                 810                 815     


Lys Pro Pro Arg Ser Ala Lys Glu Pro Leu Ile Ser Gly Trp Leu Phe 
            820                 825                 830         


Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val Gly 
        835                 840                 845             


Ala Ala Ala Trp Trp Phe Ile Val Ala Asp Asp Gly Pro Met Ile Thr 
    850                 855                 860                 


Leu Tyr Gln Leu Ser His Phe Leu Gln Cys Ser Pro Asp Asn Pro Asp 
865                 870                 875                 880 


Phe Gln Asp Leu Glu Cys His Val Phe Glu Ser Pro Tyr Pro Met Thr 
                885                 890                 895     


Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu Asn 
            900                 905                 910         


Ser Leu Ser Glu Asn Gln Ser Leu Val Arg Met Pro Pro Trp Glu Asn 
        915                 920                 925             


Ile Trp Leu Leu Gly Ala Ile Cys Leu Ser Met Ser Leu His Phe Leu 
    930                 935                 940                 


Ile Leu Tyr Val Glu Pro Leu Pro Val Ile Phe Gln Ile Thr Pro Leu 
945                 950                 955                 960 


Asn Val Thr Gln Trp Met Met Val Leu Lys Ile Ser Leu Pro Val Ile 
                965                 970                 975     


Leu Leu Asp Glu Leu Leu Lys Phe Val Ala Arg Thr Tyr Leu Glu Pro 
            980                 985                 990         


Ala Pro Glu Asp 
        995     


<210>  14
<211>  990
<212>  PRT
<213>  Silurus Lanzhouensis

<400>  14

Met Glu Asn Ala His Thr Lys Ser Pro Ala Glu Val Ile Ser Phe Phe 
1               5                   10                  15      


Gly Val Ser Glu Thr Thr Gly Leu Thr Pro Asp Gln Val Lys Arg Asn 
            20                  25                  30          


Met Ala Lys Tyr Gly Pro Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Ile Trp Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Val Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Ile Ala Asn Ala Val Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Ser Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Arg Glu 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ser Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Ile Thr Ala Ile Arg Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Ala Val Pro Asp Leu Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Ile Gly Val Cys Ile 
    210                 215                 220                 


Ala Thr Gly Val Ser Thr Glu Ile Gly Lys Ile Arg Asp Gln Met Ala 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Lys Thr Ser Leu Gln Gln Lys Leu Glu Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Val Ala Val Trp 
            260                 265                 270         


Met Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Arg Arg His Cys Arg Ser Leu Pro 
                325                 330                 335     


Ser Val Arg Leu Trp Gly Cys Thr Ser Val Ser Ala Gln Thr Asn Arg 
            340                 345                 350         


Ala Leu Ser Pro Leu Ser Glu Trp Cys Val Thr Lys Met Phe Val Ile 
        355                 360                 365             


Asp Glu Trp Met Val Ile Thr Val Pro Glu Cys Ser Ile Ser Pro Pro 
    370                 375                 380                 


Leu Asn Asn Thr Pro Glu Gly Glu Val Thr Lys Gly Arg Val Leu Lys 
385                 390                 395                 400 


Leu Thr Ala Val Ser Thr Met Ala Leu Val Glu Leu Ala Thr Ile Cys 
                405                 410                 415     


Ala Leu Cys Asn Val Ser Ser Leu Asp Phe Asn Glu Ser Lys Lys Ile 
            420                 425                 430         


Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Cys Cys Leu Val 
        435                 440                 445             


Glu Lys Met Asn Val Phe Lys Thr Ser Val Asn Asn Leu Ser Cys Val 
    450                 455                 460                 


Glu Arg Ala Asn Ala Cys Cys Ser Val Val Lys Gln Leu Met Lys Lys 
465                 470                 475                 480 


Asn Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val Tyr 
                485                 490                 495     


Cys Thr Pro Thr Arg Gly Glu Ser Gly Ser Lys Met Phe Val Lys Gly 
            500                 505                 510         


Ala Pro Glu Gly Val Ile Asp Arg Cys Thr Tyr Val Arg Val Gly Ser 
        515                 520                 525             


Ala Arg Val Pro Leu Thr Gly Pro Ile Lys Asp Lys Ile Leu Thr Ile 
    530                 535                 540                 


Ile Lys Glu Trp Gly Thr Gly Arg Asp Thr Leu Arg Cys Leu Ala Leu 
545                 550                 555                 560 


Ala Thr Arg Asp Ser Pro Leu Lys Val Glu Glu Met Lys Leu Glu Asp 
                565                 570                 575     


Ala Thr Lys Phe Ala Asp Tyr Glu Thr Asp Leu Thr Ser Val Gly Cys 
            580                 585                 590         


Val Gly Met Leu Asp Pro Pro Arg Lys Glu Val Ser Gly Ser Ile Gln 
        595                 600                 605             


Leu Cys Lys Asp Ala Gly Ile Arg Val Ile Met Ile Thr Gly Asp Asn 
    610                 615                 620                 


Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile Phe Ser Glu 
625                 630                 635                 640 


Asp Glu Asp Val Thr Gly Arg Ala Tyr Thr Gly Arg Glu Phe Asp Asp 
                645                 650                 655     


Leu Pro Arg Ala Glu Gln Ser Glu Ala Val Thr Arg Ala Cys Cys Phe 
            660                 665                 670         


Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu Tyr Leu Gln 
        675                 680                 685             


Gly His Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val Asn Asp Ala 
    690                 695                 700                 


Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly Ser Gly Thr 
705                 710                 715                 720 


Ala Val Ala Lys Ser Ala Ser Glu Met Val Leu Ala Asp Asp Asn Phe 
                725                 730                 735     


Ser Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile Tyr Asn Asn 
            740                 745                 750         


Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val Gly Glu Val 
        755                 760                 765             


Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Leu Pro Glu Ala Leu Ile 
    770                 775                 780                 


Pro Val Arg Leu Leu Trp Val Asn Leu Val Thr Asp Gly Leu Pro Ala 
785                 790                 795                 800 


Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met Gly Lys Ala 
                805                 810                 815     


Pro Arg Ser Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu Phe Phe Arg 
            820                 825                 830         


Tyr Leu Val Ile Gly Gly Tyr Val Gly Ala Ala Thr Val Gly Ala Ala 
        835                 840                 845             


Ala Tyr Trp Phe Leu Tyr Asp Asp Glu Gly Pro Lys Val Thr Tyr Tyr 
    850                 855                 860                 


Gln Leu Ser His Phe Met Gln Cys His Asp Glu Asn Glu Asp Phe Ala 
865                 870                 875                 880 


Gly Ile Glu Cys Glu Val Phe Glu Ala Ala Pro Pro Met Thr Met Ala 
                885                 890                 895     


Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu Asn Ser Leu 
            900                 905                 910         


Ser Glu Asn Gln Ser Leu Ile Arg Met Pro Pro Trp Ser Asn Phe Trp 
        915                 920                 925             


Leu Leu Ala Ala Met Thr Leu Ser Met Ser Leu His Phe Met Ile Ile 
    930                 935                 940                 


Tyr Val Asp Pro Leu Pro Met Val Phe Lys Leu Thr His Leu Asn Val 
945                 950                 955                 960 


Glu Gln Trp Leu Val Val Leu Lys Leu Ser Phe Pro Val Ile Leu Ile 
                965                 970                 975     


Asp Glu Val Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu Ala 
            980                 985                 990 


<210>  15
<211>  1035
<212>  PRT
<213>  Danio rerio

<400>  15

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Tyr Ser Phe Phe 
1               5                   10                  15      


Ala Val Asn Glu Ser Thr Gly Leu Gly Leu Glu Gln Val Lys Arg Gln 
            20                  25                  30          


Arg Glu Lys Trp Gly Pro Asn Gly Lys Ser Leu Trp Glu Leu Val Val 
        35                  40                  45              


Glu Gln Phe Glu Asp Leu Leu Val Arg Ile Leu Leu Leu Ala Ala Cys 
    50                  55                  60                  


Ile Ser Phe Val Leu Ala Trp Phe Glu Glu Gly Glu Glu Thr Ile Thr 
65                  70                  75                  80  


Ala Phe Val Glu Pro Phe Val Ile Leu Leu Ile Leu Ile Ala Asn Ala 
                85                  90                  95      


Ile Val Gly Val Trp Gln Glu Arg Asn Ala Glu Asn Ala Ile Glu Ala 
            100                 105                 110         


Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys Val Tyr Arg Gln Asp Arg 
        115                 120                 125             


Lys Thr Val Gln Arg Ile Lys Ala Arg Asp Ile Val Pro Gly Asp Ile 
    130                 135                 140                 


Val Glu Val Ala Val Gly Asp Lys Val Pro Ala Asp Ile Arg Leu Thr 
145                 150                 155                 160 


Ser Ile Lys Ser Thr Thr Leu Arg Val Asp Gln Ser Ile Leu Thr Gly 
                165                 170                 175     


Glu Ser Val Ser Val Ile Lys His Thr Asp Pro Val Pro Asp Pro Arg 
            180                 185                 190         


Ala Val Asn Gln Asp Lys Lys Asn Met Leu Phe Ser Gly Thr Asn Ile 
        195                 200                 205             


Ala Ala Gly Lys Ala Val Gly Val Val Val Ala Thr Gly Val Asn Thr 
    210                 215                 220                 


Glu Ile Gly Lys Ile Arg Asp Glu Met Ala Ser Thr Glu Gln Glu Arg 
225                 230                 235                 240 


Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe Gly Gln Gln Leu Ser Lys 
                245                 250                 255     


Val Ile Ser Leu Ile Cys Ile Ala Val Trp Ile Ile Asn Ile Gly His 
            260                 265                 270         


Phe Asn Asp Pro Val His Gly Gly Ser Trp Val Arg Gly Ala Val Tyr 
        275                 280                 285             


Tyr Phe Lys Ile Ala Val Ala Leu Ala Val Ala Ala Ile Pro Glu Gly 
    290                 295                 300                 


Leu Pro Ala Val Ile Thr Thr Cys Leu Ala Leu Gly Thr Arg Arg Met 
305                 310                 315                 320 


Ala Lys Lys Asn Ala Ile Val Arg Ser Leu Pro Ser Val Glu Thr Leu 
                325                 330                 335     


Gly Cys Thr Ser Val Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
            340                 345                 350         


Asn Gln Met Ser Val Cys Arg Met Phe Ile Val Asp Gln Ala Asn Gly 
        355                 360                 365             


Asn Thr Cys Ser Leu Lys Glu Phe Ser Ile Ser Gly Ser Thr Tyr Ala 
    370                 375                 380                 


Pro Asp Gly Gln Val Cys His Glu Gly Lys Pro Val Gln Cys Ser Lys 
385                 390                 395                 400 


Phe Asp Ala Leu Val Glu Met Ala Ser Ile Cys Ala Leu Cys Asn Asp 
                405                 410                 415     


Ser Ser Leu Asp Tyr Asn Glu Ala Lys Gly Val Tyr Glu Lys Val Gly 
            420                 425                 430         


Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu Val Glu Lys Met Asn Val 
        435                 440                 445             


Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys Val Glu Arg Ala Asn Ala 
    450                 455                 460                 


Cys Asn Ser Val Ile Lys Gln Leu Met Lys Lys Glu Phe Thr Leu Glu 
465                 470                 475                 480 


Phe Ser Arg Asp Arg Lys Ser Met Ser Val Tyr Cys Thr Pro Asn Lys 
                485                 490                 495     


Ala Arg Ser Ser Met Gly Lys Met Phe Val Lys Gly Ala Pro Glu Gly 
            500                 505                 510         


Val Ile Asp Arg Cys Thr His Ile Arg Val Gly Gly Asn Lys Val Pro 
        515                 520                 525             


Met Thr Pro Gly Ile Lys Glu Lys Ile Met Ser Val Ile Arg Glu Tyr 
    530                 535                 540                 


Gly Thr Gly Arg Asp Thr Leu Arg Cys Leu Ala Leu Ala Thr Arg Asp 
545                 550                 555                 560 


Asn Pro Leu Ser Lys Glu Ser Leu Val Leu Glu Asp Ser Thr Arg Phe 
                565                 570                 575     


Val Glu Tyr Glu Thr Asp Leu Thr Phe Val Gly Cys Val Gly Met Leu 
            580                 585                 590         


Asp Pro Pro Arg Ala Glu Val Ala Ala Ser Ile Lys Leu Cys Arg Gln 
        595                 600                 605             


Ala Gly Ile Arg Val Ile Met Ile Thr Gly Asp Asn Lys Gly Thr Ala 
    610                 615                 620                 


Val Ala Ile Cys Arg Arg Ile Gly Ile Phe Gly Glu Asn Asp Asp Val 
625                 630                 635                 640 


Ser Arg Met Ala Tyr Thr Gly Arg Glu Phe Asp Asp Leu Ser Ala Ala 
                645                 650                 655     


Ala Gln Arg Glu Ala Val Leu Thr Ala Arg Cys Phe Ala Arg Val Glu 
            660                 665                 670         


Pro Ser His Lys Ser Lys Ile Val Glu Phe Leu Gln Ser Tyr Asp Glu 
        675                 680                 685             


Ile Thr Ala Met Thr Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys 
    690                 695                 700                 


Lys Ala Glu Ile Gly Ile Ala Met Gly Ser Gly Thr Ala Val Ala Lys 
705                 710                 715                 720 


Thr Ala Ser Glu Met Val Leu Ala Asp Asp Asn Phe Ser Thr Ile Val 
                725                 730                 735     


Ala Ala Val Glu Glu Gly Arg Ala Ile Tyr Asn Asn Met Lys Gln Phe 
            740                 745                 750         


Ile Arg Tyr Leu Ile Ser Ser Asn Val Gly Glu Val Val Cys Ile Phe 
        755                 760                 765             


Leu Thr Ala Ala Leu Gly Phe Pro Glu Ala Leu Ile Pro Val Gln Leu 
    770                 775                 780                 


Leu Trp Val Asn Leu Val Thr Asp Gly Leu Pro Ala Thr Ala Leu Gly 
785                 790                 795                 800 


Phe Asn Pro Pro Asp Leu Asp Ile Met Ser Lys Pro Pro Arg Asn Ala 
                805                 810                 815     


Arg Glu Pro Leu Ile Ser Gly Trp Leu Phe Phe Arg Tyr Leu Ala Ile 
            820                 825                 830         


Gly Cys Tyr Val Gly Ala Ala Thr Val Gly Ala Ala Ala Trp Trp Phe 
        835                 840                 845             


Ile Ala Ala Glu Asp Gly Pro Arg Val Thr Phe Tyr Gln Leu Ser His 
    850                 855                 860                 


Phe Leu Gln Cys Ala Pro Asp Asn Pro Glu Phe Glu Gly Leu Gln Cys 
865                 870                 875                 880 


Glu Ile Phe Gly Ser Pro Tyr Pro Met Thr Met Ala Leu Ser Val Leu 
                885                 890                 895     


Val Thr Ile Glu Met Cys Asn Ala Leu Asn Ser Val Ser Glu Asn Gln 
            900                 905                 910         


Ser Leu Leu His Met Pro Pro Trp Glu Asn Val Trp Leu Leu Gly Ala 
        915                 920                 925             


Ile Cys Leu Ser Met Ser Leu His Phe Leu Ile Leu Tyr Val Glu Pro 
    930                 935                 940                 


Leu Pro Met Ile Phe Gln Ile Thr Pro Leu Asn Val Thr Gln Trp Leu 
945                 950                 955                 960 


Met Val Leu Lys Ile Ser Leu Pro Val Ile Leu Leu Asp Glu Val Leu 
                965                 970                 975     


Lys Phe Ala Ala Arg Asn Tyr Leu Asp Lys Pro Lys Asp Leu Asp Asn 
            980                 985                 990         


Pro Lys Gly Lys Ala Cys Ser Leu  Ser Ala Cys Thr Glu  Gly Ile Ser 
        995                 1000                 1005             


Trp Pro  Phe Val Ala Leu Ser  Leu Pro Leu Val Leu  Trp Ile Tyr 
    1010                 1015                 1020             


Ser Thr  Asp Thr Asn Val Ala  Glu Leu Phe Trp Ser  
    1025                 1030                 1035 


<210>  16
<211>  997
<212>  PRT
<213>  Felis catus

<400>  16

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly Tyr Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Lys Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Lys Lys Phe Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Val 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met Asn 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Ser Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Asp Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Ala Ile Leu Glu 
        995         


<210>  17
<211>  1042
<212>  PRT
<213>  Sus scrofa

<400>  17

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Lys Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Met Arg Arg Glu Glu Met Asn 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Glu Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Thr Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Val Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Gly Lys Glu Cys Val Gln Pro  Ala Thr Lys Ser Cys  Ser Phe Ser 
        995                 1000                 1005             


Ala Cys  Thr Asp Gly Ile Ser  Trp Pro Phe Val Leu  Leu Ile Met 
    1010                 1015                 1020             


Pro Leu  Val Ile Trp Val Tyr  Ser Thr Asp Thr Asn  Phe Ser Asp 
    1025                 1030                 1035             


Met Phe  Trp Ser 
    1040         


<210>  18
<211>  1043
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Lys Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val Gln Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Ser Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Gly Lys Glu Cys Ala Gln Pro  Ala Thr Lys Pro Ser  Cys Ser Leu 
        995                 1000                 1005             


Ser Ala  Cys Thr Asp Gly Ile  Ser Trp Pro Phe Val  Leu Leu Ile 
    1010                 1015                 1020             


Met Pro  Leu Val Val Trp Val  Tyr Ser Thr Asp Thr  Asn Phe Ser 
    1025                 1030                 1035             


Asp Met  Phe Trp Ser 
    1040             


<210>  19
<211>  201
<212>  PRT
<213>  Sus scrofa

<400>  19

Tyr Val Gly Ala Ala Thr Val Gly Ala Ala Ala Trp Trp Phe Ile Ala 
1               5                   10                  15      


Ala Asp Gly Gly Pro Arg Val Thr Phe Tyr Gln Leu Ser His Phe Leu 
            20                  25                  30          


Gln Cys Lys Glu Asp Asn Pro Asp Phe Glu Gly Val Asp Cys Ala Val 
        35                  40                  45              


Phe Glu Ser Pro Tyr Pro Met Thr Met Ala Leu Ser Val Leu Val Thr 
    50                  55                  60                  


Ile Glu Met Cys Asn Ala Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu 
65                  70                  75                  80  


Leu Arg Met Pro Pro Trp Glu Asn Ile Trp Leu Val Gly Ser Ile Cys 
                85                  90                  95      


Leu Ser Met Ser Leu His Phe Leu Ile Leu Tyr Val Glu Pro Leu Pro 
            100                 105                 110         


Leu Ile Phe Gln Ile Thr Pro Leu Asn Leu Thr Gln Trp Leu Met Val 
        115                 120                 125             


Leu Lys Ile Ser Leu Pro Val Ile Leu Met Asp Glu Thr Leu Lys Phe 
    130                 135                 140                 


Val Ala Arg Asn Tyr Leu Glu Pro Gly Lys Glu Cys Val Gln Pro Ala 
145                 150                 155                 160 


Thr Lys Ser Cys Ser Phe Ser Ala Cys Thr Asp Gly Ile Ser Trp Pro 
                165                 170                 175     


Phe Val Leu Leu Ile Met Pro Leu Val Ile Trp Val Tyr Ser Thr Asp 
            180                 185                 190         


Thr Asn Phe Ser Asp Met Phe Trp Ser 
        195                 200     


<210>  20
<211>  156
<212>  PRT
<213>  Sus scrofa

<400>  20

Tyr Val Gly Ala Ala Thr Val Gly Ala Ala Ala Trp Trp Phe Ile Ala 
1               5                   10                  15      


Ala Asp Gly Gly Pro Arg Val Thr Phe Tyr Gln Leu Ser His Phe Leu 
            20                  25                  30          


Gln Cys Lys Glu Asp Asn Pro Asp Phe Glu Gly Val Asp Cys Ala Val 
        35                  40                  45              


Phe Glu Ser Pro Tyr Pro Met Thr Met Ala Leu Ser Val Leu Val Thr 
    50                  55                  60                  


Ile Glu Met Cys Asn Ala Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu 
65                  70                  75                  80  


Leu Arg Met Pro Pro Trp Glu Asn Ile Trp Leu Val Gly Ser Ile Cys 
                85                  90                  95      


Leu Ser Met Ser Leu His Phe Leu Ile Leu Tyr Val Glu Pro Leu Pro 
            100                 105                 110         


Leu Ile Phe Gln Ile Thr Pro Leu Asn Leu Thr Gln Trp Leu Met Val 
        115                 120                 125             


Leu Lys Ile Ser Leu Pro Val Ile Leu Met Asp Glu Thr Leu Lys Phe 
    130                 135                 140                 


Val Ala Arg Asn Tyr Leu Glu Pro Ala Ile Leu Glu 
145                 150                 155     


