                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF MICHIGAN
 
<120>  CARBAMOYL PHOSPHATE SYNTHATASE-1 FOR THE TREATMENT AND PREVENTION
        OF LIVER INJURY

<130>  UM-36997-601

<150>  US 62/811,135
<151>  2019-02-27

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1499
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Arg Ile Leu Thr Ala Phe Lys Val Val Arg Thr Leu Lys Thr 
1               5                   10                  15      


Gly Phe Gly Phe Thr Asn Val Thr Ala His Gln Lys Trp Lys Phe Ser 
            20                  25                  30          


Arg Pro Gly Ile Arg Leu Leu Ser Val Lys Ala Gln Thr Ala His Ile 
        35                  40                  45              


Val Leu Glu Asp Gly Thr Lys Met Lys Gly Tyr Ser Phe Gly His Pro 
    50                  55                  60                  


Ser Ser Val Ala Gly Glu Val Val Phe Asn Thr Gly Leu Gly Gly Tyr 
65                  70                  75                  80  


Pro Glu Ala Ile Thr Asp Pro Ala Tyr Lys Gly Gln Ile Leu Thr Met 
                85                  90                  95      


Ala Asn Pro Ile Ile Gly Asn Gly Gly Ala Pro Asp Thr Thr Ala Leu 
            100                 105                 110         


Asp Glu Leu Gly Leu Ser Lys Tyr Leu Glu Ser Asn Gly Ile Lys Val 
        115                 120                 125             


Ser Gly Leu Leu Val Leu Asp Tyr Ser Lys Asp Tyr Asn His Trp Leu 
    130                 135                 140                 


Ala Thr Lys Ser Leu Gly Gln Trp Leu Gln Glu Glu Lys Val Pro Ala 
145                 150                 155                 160 


Ile Tyr Gly Val Asp Thr Arg Met Leu Thr Lys Ile Ile Arg Asp Lys 
                165                 170                 175     


Gly Thr Met Leu Gly Lys Ile Glu Phe Glu Gly Gln Pro Val Asp Phe 
            180                 185                 190         


Val Asp Pro Asn Lys Gln Asn Leu Ile Ala Glu Val Ser Thr Lys Asp 
        195                 200                 205             


Val Lys Val Tyr Gly Lys Gly Asn Pro Thr Lys Val Val Ala Val Asp 
    210                 215                 220                 


Cys Gly Ile Lys Asn Asn Val Ile Arg Leu Leu Val Lys Arg Gly Ala 
225                 230                 235                 240 


Glu Val His Leu Val Pro Trp Asn His Asp Phe Thr Lys Met Glu Tyr 
                245                 250                 255     


Asp Gly Ile Leu Ile Ala Gly Gly Pro Gly Asn Pro Ala Leu Ala Glu 
            260                 265                 270         


Pro Leu Ile Gln Asn Val Arg Lys Ile Leu Glu Ser Asp Arg Lys Glu 
        275                 280                 285             


Pro Leu Phe Gly Ile Ser Thr Gly Asn Leu Ile Thr Gly Leu Ala Ala 
    290                 295                 300                 


Gly Ala Lys Thr Tyr Lys Met Ser Met Ala Asn Arg Gly Gln Asn Gln 
305                 310                 315                 320 


Pro Val Leu Asn Ile Thr Asn Lys Gln Ala Phe Ile Thr Ala Gln Asn 
                325                 330                 335     


His Gly Tyr Ala Leu Asp Asn Thr Leu Pro Ala Gly Trp Lys Pro Leu 
            340                 345                 350         


Phe Val Asn Val Asn Asp Gln Thr Asn Glu Gly Ile Met His Glu Ser 
        355                 360                 365             


Lys Pro Phe Phe Ala Val Gln Phe His Pro Glu Val Thr Pro Gly Pro 
    370                 375                 380                 


Ile Asp Thr Glu Tyr Leu Phe Asp Ser Phe Phe Ser Leu Ile Lys Lys 
385                 390                 395                 400 


Gly Lys Ala Thr Thr Ile Thr Ser Val Leu Pro Lys Pro Ala Leu Val 
                405                 410                 415     


Ala Ser Arg Val Glu Val Ser Lys Val Leu Ile Leu Gly Ser Gly Gly 
            420                 425                 430         


Leu Ser Ile Gly Gln Ala Gly Glu Phe Asp Tyr Ser Gly Ser Gln Ala 
        435                 440                 445             


Val Lys Ala Met Lys Glu Glu Asn Val Lys Thr Val Leu Met Asn Pro 
    450                 455                 460                 


Asn Ile Ala Ser Val Gln Thr Asn Glu Val Gly Leu Lys Gln Ala Asp 
465                 470                 475                 480 


Val Tyr Phe Leu Pro Ile Thr Pro Gln Phe Val Thr Glu Val Ile Lys 
                485                 490                 495     


Ala Glu Gln Pro Asp Gly Leu Ile Leu Gly Met Gly Gly Gln Thr Ala 
            500                 505                 510         


Leu Asn Cys Gly Val Glu Leu Phe Lys Arg Gly Val Leu Lys Glu Tyr 
        515                 520                 525             


Gly Val Lys Val Leu Gly Thr Ser Val Glu Ser Ile Met Ala Thr Glu 
    530                 535                 540                 


Asp Arg Gln Leu Phe Ser Asp Lys Leu Asn Glu Ile Asn Glu Lys Ile 
545                 550                 555                 560 


Ala Pro Ser Phe Ala Val Glu Ser Ile Glu Asp Ala Leu Lys Ala Ala 
                565                 570                 575     


Asp Thr Ile Gly Tyr Pro Val Met Ile Arg Ser Ala Tyr Ala Leu Gly 
            580                 585                 590         


Gly Leu Gly Ser Gly Ile Cys Pro Asn Arg Glu Thr Leu Met Asp Leu 
        595                 600                 605             


Ser Thr Lys Ala Phe Ala Met Thr Asn Gln Ile Leu Val Glu Lys Ser 
    610                 615                 620                 


Val Thr Gly Trp Lys Glu Ile Glu Tyr Glu Val Val Arg Asp Ala Asp 
625                 630                 635                 640 


Asp Asn Cys Val Thr Val Cys Asn Met Glu Asn Val Asp Ala Met Gly 
                645                 650                 655     


Val His Thr Gly Asp Ser Val Val Val Ala Pro Ala Gln Thr Leu Ser 
            660                 665                 670         


Asn Ala Glu Phe Gln Met Leu Arg Arg Thr Ser Ile Asn Val Val Arg 
        675                 680                 685             


His Leu Gly Ile Val Gly Glu Cys Asn Ile Gln Phe Ala Leu His Pro 
    690                 695                 700                 


Thr Ser Met Glu Tyr Cys Ile Ile Glu Val Asn Ala Arg Leu Ser Arg 
705                 710                 715                 720 


Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Tyr Pro Leu Ala Phe Ile 
                725                 730                 735     


Ala Ala Lys Ile Ala Leu Gly Ile Pro Leu Pro Glu Ile Lys Asn Val 
            740                 745                 750         


Val Ser Gly Lys Thr Ser Ala Cys Phe Glu Pro Ser Leu Asp Tyr Met 
        755                 760                 765             


Val Thr Lys Ile Pro Arg Trp Asp Leu Asp Arg Phe His Gly Thr Ser 
    770                 775                 780                 


Ser Arg Ile Gly Ser Ser Met Lys Ser Val Gly Glu Val Met Ala Ile 
785                 790                 795                 800 


Gly Arg Thr Phe Glu Glu Ser Phe Gln Lys Ala Leu Arg Met Cys His 
                805                 810                 815     


Pro Ser Ile Glu Gly Phe Thr Pro Arg Leu Pro Met Asn Lys Glu Trp 
            820                 825                 830         


Pro Ser Asn Leu Asp Leu Arg Lys Glu Leu Ser Glu Pro Ser Ser Thr 
        835                 840                 845             


Arg Ile Tyr Ala Ile Ala Lys Ala Ile Asp Asp Asn Met Ser Leu Asp 
    850                 855                 860                 


Glu Ile Glu Lys Leu Thr Tyr Ile Asp Lys Trp Phe Leu Tyr Lys Met 
865                 870                 875                 880 


Arg Asp Ile Leu Asn Met Glu Lys Thr Leu Lys Gly Leu Asn Ser Glu 
                885                 890                 895     


Ser Met Thr Glu Glu Thr Leu Lys Arg Ala Lys Glu Ile Gly Phe Ser 
            900                 905                 910         


Asp Lys Gln Ile Ser Lys Cys Leu Gly Leu Thr Glu Ala Gln Thr Arg 
        915                 920                 925             


Glu Leu Arg Leu Lys Lys Asn Ile His Pro Trp Val Lys Gln Ile Asp 
    930                 935                 940                 


Thr Leu Ala Ala Glu Tyr Pro Ser Val Thr Asn Tyr Leu Tyr Val Thr 
945                 950                 955                 960 


Tyr Asn Gly Gln Glu His Asp Val Asn Phe Asp Asp His Gly Met Met 
                965                 970                 975     


Val Leu Gly Cys Gly Pro Tyr His Ile Gly Ser Ser Val Glu Phe Asp 
            980                 985                 990         


Trp Cys Ala Val Ser Ser Ile Arg  Thr Leu Arg Gln Leu  Gly Lys Lys 
        995                 1000                 1005             


Thr Val  Val Val Asn Cys Asn  Pro Glu Thr Val Ser  Thr Asp Phe 
    1010                 1015                 1020             


Asp Glu  Cys Asp Lys Leu Tyr  Phe Glu Glu Leu Ser  Leu Glu Arg 
    1025                 1030                 1035             


Ile Leu  Asp Ile Tyr His Gln  Glu Ala Cys Gly Gly  Cys Ile Ile 
    1040                 1045                 1050             


Ser Val  Gly Gly Gln Ile Pro  Asn Asn Leu Ala Val  Pro Leu Tyr 
    1055                 1060                 1065             


Lys Asn  Gly Val Lys Ile Met  Gly Thr Ser Pro Leu  Gln Ile Asp 
    1070                 1075                 1080             


Arg Ala  Glu Asp Arg Ser Ile  Phe Ser Ala Val Leu  Asp Glu Leu 
    1085                 1090                 1095             


Lys Val  Ala Gln Ala Pro Trp  Lys Ala Val Asn Thr  Leu Asn Glu 
    1100                 1105                 1110             


Ala Leu  Glu Phe Ala Lys Ser  Val Asp Tyr Pro Cys  Leu Leu Arg 
    1115                 1120                 1125             


Pro Ser  Tyr Val Leu Ser Gly  Ser Ala Met Asn Val  Val Phe Ser 
    1130                 1135                 1140             


Glu Asp  Glu Met Lys Lys Phe  Leu Glu Glu Ala Thr  Arg Val Ser 
    1145                 1150                 1155             


Gln Glu  His Pro Val Val Leu  Thr Lys Phe Val Glu  Gly Ala Arg 
    1160                 1165                 1170             


Glu Val  Glu Met Asp Ala Val  Gly Lys Asp Gly Arg  Val Ile Ser 
    1175                 1180                 1185             


His Ala  Ile Ser Glu His Val  Glu Asp Ala Gly Val  His Ser Gly 
    1190                 1195                 1200             


Asp Ala  Thr Leu Met Leu Pro  Thr Gln Thr Ile Ser  Gln Gly Ala 
    1205                 1210                 1215             


Ile Glu  Lys Val Lys Asp Ala  Thr Arg Lys Ile Ala  Lys Ala Phe 
    1220                 1225                 1230             


Ala Ile  Ser Gly Pro Phe Asn  Val Gln Phe Leu Val  Lys Gly Asn 
    1235                 1240                 1245             


Asp Val  Leu Val Ile Glu Cys  Asn Leu Arg Ala Ser  Arg Ser Phe 
    1250                 1255                 1260             


Pro Phe  Val Ser Lys Thr Leu  Gly Val Asp Phe Ile  Asp Val Ala 
    1265                 1270                 1275             


Thr Lys  Val Met Ile Gly Glu  Asn Val Asp Glu Lys  His Leu Pro 
    1280                 1285                 1290             


Thr Leu  Asp His Pro Ile Ile  Pro Ala Asp Tyr Val  Ala Ile Lys 
    1295                 1300                 1305             


Ala Pro  Met Phe Ser Trp Pro  Arg Leu Arg Asp Ala  Asp Pro Ile 
    1310                 1315                 1320             


Leu Arg  Cys Glu Met Ala Ser  Thr Gly Glu Val Ala  Cys Phe Gly 
    1325                 1330                 1335             


Glu Gly  Ile His Thr Ala Phe  Leu Lys Ala Met Leu  Ser Thr Gly 
    1340                 1345                 1350             


Phe Lys  Ile Pro Gln Lys Gly  Ile Leu Ile Gly Ile  Gln Gln Ser 
    1355                 1360                 1365             


Phe Arg  Pro Arg Phe Leu Gly  Val Ala Glu Gln Leu  His Asn Glu 
    1370                 1375                 1380             


Gly Phe  Lys Leu Phe Ala Thr  Glu Ala Thr Ser Asp  Trp Leu Asn 
    1385                 1390                 1395             


Ala Asn  Asn Val Pro Ala Thr  Pro Val Ala Trp Pro  Ser Gln Glu 
    1400                 1405                 1410             


Gly Gln  Asn Pro Ser Leu Ser  Ser Ile Arg Lys Leu  Ile Arg Asp 
    1415                 1420                 1425             


Gly Ser  Ile Asp Leu Val Ile  Asn Leu Pro Asn Asn  Asn Thr Lys 
    1430                 1435                 1440             


Phe Val  His Asp Asn Tyr Val  Ile Arg Arg Thr Ala  Val Asp Ser 
    1445                 1450                 1455             


Gly Ile  Pro Leu Leu Thr Asn  Phe Gln Val Thr Lys  Leu Phe Ala 
    1460                 1465                 1470             


Glu Ala  Val Gln Lys Ser Arg  Lys Val Asp Ser Lys  Ser Leu Phe 
    1475                 1480                 1485             


His Tyr  Arg Gln Tyr Ser Ala  Gly Lys Ala Ala 
    1490                 1495                 


<210>  2
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Arg Ile Leu Thr Ala Phe Lys Val Val Arg Thr Leu Lys Thr 
1               5                   10                  15      


Gly Phe Gly Phe Thr Asn Val Thr Ala His Gln Lys Trp Lys Phe Ser 
            20                  25                  30          


Arg Pro Gly Ile Arg Leu 
        35              


<210>  3
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Ser Val Lys Ala Gln Thr Ala His Ile Val Leu Glu Asp Gly Thr 
1               5                   10                  15      


Lys Met Lys Gly Tyr Ser Phe Gly His Pro Ser Ser Val Ala Gly Glu 
            20                  25                  30          


Val Val Phe Asn Thr Gly Leu Gly Gly Tyr Pro Glu Ala Ile Thr Asp 
        35                  40                  45              


Pro Ala Tyr Lys Gly Gln Ile Leu Thr Met Ala Asn Pro Ile Ile Gly 
    50                  55                  60                  


Asn Gly Gly Ala Pro Asp Thr Thr Ala Leu Asp Glu Leu Gly Leu Ser 
65                  70                  75                  80  


Lys Tyr Leu Glu Ser Asn Gly Ile Lys Val Ser Gly Leu Leu Val Leu 
                85                  90                  95      


Asp Tyr Ser Lys Asp Tyr Asn His Trp Leu Ala Thr Lys Ser Leu Gly 
            100                 105                 110         


Gln Trp Leu Gln Glu Glu Lys Val Pro Ala Ile Tyr Gly Val Asp Thr 
        115                 120                 125             


Arg Met Leu Thr Lys Ile Ile Arg Asp Lys Gly Thr Met Leu Gly Lys 
    130                 135                 140                 


Ile Glu Phe Glu Gly Gln Pro Val Asp Phe Val Asp Pro 
145                 150                 155         


<210>  4
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  4

Asn Lys Gln Asn Leu Ile Ala Glu Val Ser Thr Lys Asp Val Lys Val 
1               5                   10                  15      


Tyr Gly Lys Gly Asn Pro Thr Lys Val Val Ala Val Asp Cys Gly Ile 
            20                  25                  30          


Lys Asn Asn Val Ile Arg Leu Leu Val Lys Arg Gly Ala Glu Val His 
        35                  40                  45              


Leu Val Pro Trp Asn His Asp Phe Thr Lys Met Glu Tyr Asp Gly Ile 
    50                  55                  60                  


Leu Ile Ala Gly Gly Pro Gly Asn Pro Ala Leu Ala Glu Pro Leu Ile 
65                  70                  75                  80  


Gln Asn Val Arg Lys Ile Leu Glu Ser Asp Arg Lys Glu Pro Leu Phe 
                85                  90                  95      


Gly Ile Ser Thr Gly Asn Leu Ile Thr Gly Leu Ala Ala Gly Ala Lys 
            100                 105                 110         


Thr Tyr Lys Met Ser Met Ala Asn Arg Gly Gln Asn Gln Pro Val Leu 
        115                 120                 125             


Asn Ile Thr Asn Lys Gln Ala Phe Ile Thr Ala Gln Asn His Gly Tyr 
    130                 135                 140                 


Ala Leu Asp Asn Thr Leu Pro Ala Gly Trp Lys Pro Leu Phe Val Asn 
145                 150                 155                 160 


Val Asn Asp Gln Thr Asn Glu Gly Ile Met His Glu Ser Lys Pro Phe 
                165                 170                 175     


Phe Ala Val Gln Phe His Pro Glu Val Thr Pro Gly Pro Ile Asp Thr 
            180                 185                 190         


Glu Tyr Leu Phe Asp Ser Phe Phe Ser Leu Ile Lys Lys Gly Lys Ala 
        195                 200                 205             


Thr Thr Ile Thr Ser Val Leu Pro Lys Pro Ala Leu 
    210                 215                 220 


<210>  5
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Ala Ser Arg Val Glu Val Ser Lys Val Leu Ile Leu Gly Ser Gly 
1               5                   10                  15      


Gly Leu Ser Ile Gly Gln Ala Gly Glu Phe Asp Tyr Ser Gly Ser Gln 
            20                  25                  30          


Ala Val Lys Ala Met Lys Glu Glu Asn Val Lys Thr Val Leu Met Asn 
        35                  40                  45              


Pro Asn Ile Ala Ser Val Gln Thr Asn Glu Val Gly Leu Lys Gln Ala 
    50                  55                  60                  


Asp Thr Val Tyr Phe Leu Pro Ile Thr Pro Gln Phe Val Thr Glu Val 
65                  70                  75                  80  


Ile Lys Ala Glu Gln Pro Asp Gly Leu Ile Leu Gly Met Gly Gly Gln 
                85                  90                  95      


Thr Ala Leu Asn Cys Gly Val Glu Leu Phe Lys Arg Gly Val Leu Lys 
            100                 105                 110         


Glu Tyr Gly Val Lys Val Leu Gly Thr Ser Val Glu Ser Ile Met Ala 
        115                 120                 125             


Thr Glu Asp Arg Gln Leu Phe Ser Asp Lys Leu Asn Glu Ile Asn Glu 
    130                 135                 140                 


Lys Ile Ala Pro Ser Phe Ala Val Glu Ser Ile Glu Asp Ala Leu Lys 
145                 150                 155                 160 


Ala Ala Asp Thr Ile Gly Tyr Pro Val Met Ile Arg Ser Ala Tyr Ala 
                165                 170                 175     


Leu Gly Gly Leu Gly Ser Gly Ile Cys Pro Asn Arg Glu Thr Leu Met 
            180                 185                 190         


Asp Leu Ser Thr Lys Ala Phe Ala Met Thr Asn Gln Ile Leu Val Glu 
        195                 200                 205             


Lys Ser Val Thr Gly Trp Lys Glu Ile Glu Tyr Glu Val Val Arg Asp 
    210                 215                 220                 


Ala Asp Asp Asn Cys Val Thr Val Cys Asn Met Glu Asn Val Asp Ala 
225                 230                 235                 240 


Met Gly Val His Thr Gly Asp Ser Val Val Val Ala Pro Ala Gln Thr 
                245                 250                 255     


Leu Ser Asn Ala Glu Phe Gln Met Leu Arg Arg Thr Ser Ile Asn Val 
            260                 265                 270         


Val Arg His Leu Gly Ile Val Gly Glu Cys Asn Ile Gln Phe Ala Leu 
        275                 280                 285             


His Pro Thr Ser Met Glu Tyr Cys Ile Ile Glu Val Asn Ala Arg Leu 
    290                 295                 300                 


Ser Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Tyr Pro Leu Ala 
305                 310                 315                 320 


Phe Ile Ala Ala Lys Ile Ala Leu Gly Ile Pro Leu Pro Glu Ile Lys 
                325                 330                 335     


Asn Val Val Ser Gly Lys Thr Ser Ala Cys Phe Glu Pro Ser Leu Asp 
            340                 345                 350         


Tyr Met Val Thr Lys Ile Pro Arg Trp Asp Leu Asp Arg Phe His Gly 
        355                 360                 365             


Thr Ser Ser Arg Ile Gly Ser Ser Met Lys Ser Val Gly Glu Val Met 
    370                 375                 380                 


Ala Ile Gly Arg Thr Phe Glu Glu Ser Phe Gln Lys Ala Leu Arg Met 
385                 390                 395                 400 


Cys His Pro Ser Ile 
                405 


<210>  6
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Gly Phe Thr Pro Arg Leu Pro Met Asn Lys Glu Trp Pro Ser Asn 
1               5                   10                  15      


Leu Asp Leu Arg Lys Glu Leu Ser Glu Pro Ser Ser Thr Arg Ile Tyr 
            20                  25                  30          


Ala Ile Ala Lys Ala Ile Asp Asp Asn Met Ser Leu Asp Glu Ile Glu 
        35                  40                  45              


Lys Leu Thr Tyr Ile Asp Lys Trp Phe Leu Tyr Lys Met Arg Asp Ile 
    50                  55                  60                  


Leu Asn Met Glu Lys Thr Leu Lys Gly Leu Asn Ser Glu Ser Met Thr 
65                  70                  75                  80  


Glu Glu Thr Leu Lys Arg Ala Lys Glu Ile Gly Phe Ser Asp Lys Gln 
                85                  90                  95      


Ile Ser Lys Cys Leu Gly Leu Thr Glu Ala Gln Thr Arg Glu Leu Arg 
            100                 105                 110         


Leu Lys Lys Asn Ile His Pro Trp Val Lys Gln Ile Asp Thr Leu Ala 
        115                 120                 125             


Ala Glu Tyr Pro Ser Val Thr Asn Tyr Leu Tyr Val Thr Tyr Asn Gly 
    130                 135                 140                 


Gln Glu His Asp Val Asn Phe Asp 
145                 150         


<210>  7
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp His Gly Met Met Val Leu Gly Cys Gly Pro Tyr His Ile Gly Ser 
1               5                   10                  15      


Ser Val Glu Phe Asp Trp Cys Ala Val Ser Ser Ile Arg Thr Leu Arg 
            20                  25                  30          


Gln Leu Gly Lys Lys Thr Val Val Val Asn Cys Asn Pro Glu Thr Val 
        35                  40                  45              


Ser Thr Asp Phe Asp Glu Cys Asp Lys Leu Tyr Phe Glu Glu Leu Ser 
    50                  55                  60                  


Leu Glu Arg Ile Leu Asp Ile Tyr His Gln Glu Ala Cys Gly Gly Cys 
65                  70                  75                  80  


Ile Ile Ser Val Gly Gly Gln Ile Pro Asn Asn Leu Ala Val Pro Leu 
                85                  90                  95      


Tyr Lys Asn Gly Val Lys Ile Met Gly Thr Ser Pro Leu Gln Ile Asp 
            100                 105                 110         


Arg Ala Glu Asp Arg Ser Ile Phe Ser Ala Val Leu Asp Glu Leu Lys 
        115                 120                 125             


Val Ala Gln Ala Pro Trp Lys Ala Val Asn Thr Leu Asn Glu Ala Leu 
    130                 135                 140                 


Glu Phe Ala Lys Ser Val Asp Tyr Pro Cys Leu Leu Arg Pro Ser Tyr 
145                 150                 155                 160 


Val Leu Ser Gly Ser Ala Met Asn Val Val Phe Ser Glu Asp Glu Met 
                165                 170                 175     


Lys Lys Phe Leu Glu Glu Ala Thr Arg Val Ser Gln Glu His Pro Val 
            180                 185                 190         


Val Leu Thr Lys Phe Val Glu Gly Ala Arg Glu Val Glu Met Asp Ala 
        195                 200                 205             


Val Gly Lys Asp Gly Arg Val Ile Ser His Ala Ile Ser Glu His Val 
    210                 215                 220                 


Glu Asp Ala Gly Val His Ser Gly Asp Ala Thr Leu Met Leu Pro Thr 
225                 230                 235                 240 


Gln Thr Ile Ser Gln Gly Ala Ile Glu Lys Val Lys Asp Ala Thr Arg 
                245                 250                 255     


Lys Ile Ala Lys Ala Phe Ala Ile Ser Gly Pro Phe Asn Val Gln Phe 
            260                 265                 270         


Leu Val Lys Gly Asn Asp Val Leu Val Ile Glu Cys Asn Leu Arg Ala 
        275                 280                 285             


Ser Arg Ser Phe Pro Phe Val Ser Lys Thr Leu Gly Val Asp Phe Ile 
    290                 295                 300                 


Asp Val Ala Thr Lys Val Met Ile Gly Glu Asn Val Asp Glu Lys His 
305                 310                 315                 320 


Leu Pro Thr Leu Asp His Pro Ile Ile Pro Ala Asp Tyr Val Ala Ile 
                325                 330                 335     


Lys Ala Pro Met Phe Ser Trp Pro Arg Leu Arg Asp Ala Asp Pro Ile 
            340                 345                 350         


Leu Arg Cys Glu Met Ala Ser Thr Gly Glu Val Ala Cys Phe Gly Glu 
        355                 360                 365             


Gly Ile His Thr Ala Phe Leu Lys Ala Met Leu Ser Thr Gly Phe Lys 
    370                 375                 380                 


Ile Pro Gln Lys Gly Ile Leu 
385                 390     


<210>  8
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Gly Ile Gln Gln Ser Phe Arg Pro Arg Phe Leu Gly Val Ala Glu 
1               5                   10                  15      


Gln Leu His Asn Glu Gly Phe Lys Leu Phe Ala Thr Glu Ala Thr Ser 
            20                  25                  30          


Asp Trp Leu Asn Ala Asn Asn Val Pro Ala Thr Pro Val Ala Trp Pro 
        35                  40                  45              


Ser Gln Glu Gly Gln Asn Pro Ser Leu Ser Ser Ile Arg Lys Leu Ile 
    50                  55                  60                  


Arg Asp Gly Ser Ile Asp Leu Val Ile Asn Leu Pro Asn Asn Asn Thr 
65                  70                  75                  80  


Lys Phe Val His Asp Asn Tyr Val Ile Arg Arg Thr Ala Val Asp Ser 
                85                  90                  95      


Gly Ile Pro Leu Leu Thr Asn Phe Gln Val Thr Lys Leu Phe Ala Glu 
            100                 105                 110         


Ala Val Gln Lys Ser Arg Lys Val Asp Ser Lys Ser Leu Phe His Tyr 
        115                 120                 125             


Arg Gln Tyr Ser Ala Gly Lys Ala Ala 
    130                 135         


