                         SEQUENCE LISTING

<110>  University of Rochester
       University of Kentucky Research Foundation
       Zoetis Services LLC
       Martinez-Sobrido, Luis
       Chambers, Thomas
       King, Kendall  W
 
<120>  Multivalent Live-attenuated Influenza Vaccine for Prevention and 
       Control of Equine Influenza Virus (EIV) in Horses

<130>  204606-0115-00WO

<150>  US 62/811,112
<151>  2019-02-27

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  2341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized - mutant segment 1 based on 
       A/equine/Ohio/1/2003 H3N8 EIV

<400>  1
agcgaaagca ggtcaaatat attcaatatg gagagaataa aagaactgag agatctgatg       60

ttacaatccc gcacccgcga gatactaaca aaaactactg tggaccacat ggccataatc      120

aagaaataca catcaggaag acaagagaag aaccctgcac ttaggatgaa atggatgatg      180

gcaatgaaat acccaatcac ggcagataag aggataatgg agatgattcc tgagagaaat      240

gaacagggac aaaccctttg gagcaaaacg aacgatgctg gctcagaccg cgtaatggta      300

tcacctctgg cagtgacatg gtggaatagg aatggaccaa caacaagcac aattcattat      360

ccaaaagtct acaaaactta ttttgaaaag gttgaaagat tgaaacacgg aacctttggc      420

cccgttcatt ttaggaatca agtcaagata agacgaagag ttgatgtaaa ccctggtcac      480

gcggacctca gtgccaaaga agcacaagat gtgatcatgg aagttgtttt cccaaatgaa      540

gtgggagcca gaattctaac atcggaatca caactaacaa taaccaaaga gaaaaaggaa      600

gaacttcagg actgcaaaat tgctcccttg atggtagcat acatgctaga aagagagttg      660

gtccgaaaaa caaggttcct cccagtagca ggcggaacaa gcagtgtata cattgaagtg      720

ttgcatctga ctcagggaac atgctgggag caaatgtaca ccccaggagg agaagttaga      780

aacgatgata ttgatcaaag tttaattatt gcagcacgat cgatagtgag aagagcaaca      840

gtatcagcag atccactagc atccctactg gaaatgtgcc acagtacaca gattggtgga      900

ataaggatgg tagacatcct taagcagaat ccaacagagg aacaagctgt ggatatatgc      960

aaagcagcaa tgggattgag aattagctca tcattcagct ttggtggatt caccttcaaa     1020

agaacaagtg gatcatcagt caagagagaa gaagaaatgc ttacgggcaa ccttcaaaca     1080

ttgaaaataa gaatgcatga gggctatgaa gaattcacaa tggtcggaag aagagcaaca     1140

gctattctca gaaaggcaac cagaagattg attcaattga tagtaagtgg gagagatgaa     1200

caatcaattg ctgaagcaat aattgtagcc atggtgtttt cgcaagaaga ttgcatgata     1260

aaagcagttc gaggcgattt gaactttgtt aatagagcaa atcagcgttt gaaccccatg     1320

catcaactct tgaggcattt ccaaaaagat gcaaaagtgc ttttccaaaa ttggggaatt     1380

gaacccatcg acaatgtaat ggggatgatt ggaatattgc ctgacatgac cccaagcacc     1440

gagatgtcat tgagaggagt gagagtcagc aaaatgggag tggatgagta ctccagcact     1500

gagagagtgg tggtgagcat tgaccgtttt ttaagagttc gggatcaaag gggaaacata     1560

ctactgtccc ctgaagaagt cagtgaaaca caaggaacgg aaaagctgac aataatttat     1620

tcgtcatcaa tgatgtggga gattaatggt cccgaatcag tgttggtcaa tacttatcaa     1680

tggatcatca ggaactggga aattgtaaaa attcagtggt cacaggaccc cacaatgtta     1740

tacaataaga tagaatttga gccattccaa tccctggtcc ctagggccac cagaagccaa     1800

tacagcggtt tcgtaagaac cctgtttcag caaatgcgag atgtacttgg aacatttgat     1860

actgctcaaa taataaaact cctccctttt gccgctgctc ctccggaaca gagtaggatg     1920

cagttctctt ctttgactgt taatgtaaga ggttcgggaa tgaggatact tgtaagaggc     1980

aattccccag tgttcaacta caataaagcc actaaaaggc tcacagtcct cggaaaggat     2040

gcaggtgcgc ttactgagga cccagatgaa ggtacggctg gagtagaatc tgctgttcta     2100

agagggtttc tcattttagg taaagaaaac aagagatatg gcccagcact aagcatcaat     2160

gaactaagca aacttgcaaa aggggagaaa gccaatgtac taattgggca aggggacgta     2220

gtgttggtaa tgaaacggaa acgtgactct agcatactta ctgacagcca gacagcgacc     2280

aaaaggattc ggatggccat caattagtgt tgaattgttt aaaaacgacc ttgtttctac     2340

t                                                                     2341


<210>  2
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized - mutant PB2 based on A/equine/Ohio/1/2003
       H3N8 EIV

<400>  2

Met Glu Arg Ile Lys Glu Leu Arg Asp Leu Met Leu Gln Ser Arg Thr 
1               5                   10                  15      


Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 
            20                  25                  30          


Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys 
        35                  40                  45              


Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Met 
    50                  55                  60                  


Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys 
65                  70                  75                  80  


Thr Asn Asp Ala Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 
                85                  90                  95      


Thr Trp Trp Asn Arg Asn Gly Pro Thr Thr Ser Thr Ile His Tyr Pro 
            100                 105                 110         


Lys Val Tyr Lys Thr Tyr Phe Glu Lys Val Glu Arg Leu Lys His Gly 
        115                 120                 125             


Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg 
    130                 135                 140                 


Val Asp Val Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln 
145                 150                 155                 160 


Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile 
                165                 170                 175     


Leu Thr Ser Glu Ser Gln Leu Thr Ile Thr Lys Glu Lys Lys Glu Glu 
            180                 185                 190         


Leu Gln Asp Cys Lys Ile Ala Pro Leu Met Val Ala Tyr Met Leu Glu 
        195                 200                 205             


Arg Glu Leu Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr 
    210                 215                 220                 


Ser Ser Val Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp 
225                 230                 235                 240 


Glu Gln Met Tyr Thr Pro Gly Gly Glu Val Arg Asn Asp Asp Ile Asp 
                245                 250                 255     


Gln Ser Leu Ile Ile Ala Ala Arg Ser Ile Val Arg Arg Ala Thr Val 
            260                 265                 270         


Ser Ala Asp Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln 
        275                 280                 285             


Ile Gly Gly Ile Arg Met Val Asp Ile Leu Lys Gln Asn Pro Thr Glu 
    290                 295                 300                 


Glu Gln Ala Val Asp Ile Cys Lys Ala Ala Met Gly Leu Arg Ile Ser 
305                 310                 315                 320 


Ser Ser Phe Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Ser Gly Ser 
                325                 330                 335     


Ser Val Lys Arg Glu Glu Glu Met Leu Thr Gly Asn Leu Gln Thr Leu 
            340                 345                 350         


Lys Ile Arg Met His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Arg 
        355                 360                 365             


Arg Ala Thr Ala Ile Leu Arg Lys Ala Thr Arg Arg Leu Ile Gln Leu 
    370                 375                 380                 


Ile Val Ser Gly Arg Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val 
385                 390                 395                 400 


Ala Met Val Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly 
                405                 410                 415     


Asp Leu Asn Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His 
            420                 425                 430         


Gln Leu Leu Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn 
        435                 440                 445             


Trp Gly Ile Glu Pro Ile Asp Asn Val Met Gly Met Ile Gly Ile Leu 
    450                 455                 460                 


Pro Asp Met Thr Pro Ser Thr Glu Met Ser Leu Arg Gly Val Arg Val 
465                 470                 475                 480 


Ser Lys Met Gly Val Asp Glu Tyr Ser Ser Thr Glu Arg Val Val Val 
                485                 490                 495     


Ser Ile Asp Arg Phe Leu Arg Val Arg Asp Gln Arg Gly Asn Ile Leu 
            500                 505                 510         


Leu Ser Pro Glu Glu Val Ser Glu Thr Gln Gly Thr Glu Lys Leu Thr 
        515                 520                 525             


Ile Ile Tyr Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser 
    530                 535                 540                 


Val Leu Val Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Ile Val 
545                 550                 555                 560 


Lys Ile Gln Trp Ser Gln Asp Pro Thr Met Leu Tyr Asn Lys Ile Glu 
                565                 570                 575     


Phe Glu Pro Phe Gln Ser Leu Val Pro Arg Ala Thr Arg Ser Gln Tyr 
            580                 585                 590         


Ser Gly Phe Val Arg Thr Leu Phe Gln Gln Met Arg Asp Val Leu Gly 
        595                 600                 605             


Thr Phe Asp Thr Ala Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala 
    610                 615                 620                 


Pro Pro Glu Gln Ser Arg Met Gln Phe Ser Ser Leu Thr Val Asn Val 
625                 630                 635                 640 


Arg Gly Ser Gly Met Arg Ile Leu Val Arg Gly Asn Ser Pro Val Phe 
                645                 650                 655     


Asn Tyr Asn Lys Ala Thr Lys Arg Leu Thr Val Leu Gly Lys Asp Ala 
            660                 665                 670         


Gly Ala Leu Thr Glu Asp Pro Asp Glu Gly Thr Ala Gly Val Glu Ser 
        675                 680                 685             


Ala Val Leu Arg Gly Phe Leu Ile Leu Gly Lys Glu Asn Lys Arg Tyr 
    690                 695                 700                 


Gly Pro Ala Leu Ser Ile Asn Glu Leu Ser Lys Leu Ala Lys Gly Glu 
705                 710                 715                 720 


Lys Ala Asn Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys 
                725                 730                 735     


Arg Lys Arg Asp Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys 
            740                 745                 750         


Arg Ile Arg Met Ala Ile Asn 
        755                 


<210>  3
<211>  2341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized - mutant segment 2 based on 
       A/equine/Ohio/1/2003 H3N8 EIV

<400>  3
agcgaaagca ggcaaaccat ttgaatggat gtcaatccga ctctactttt cttaaaggtg       60

ccagcgcaaa atgctataag cacaacattc ccttatactg gagatcctcc ctacagtcat      120

ggaacaggga caggatacac catggatact gtcaacagaa cacaccaata ttcagaaaaa      180

gggaaatgga caacaaacac tgagattgga gcaccacaac ttaatccaat cgatggacca      240

cttcctgaag acaatgaacc aagtgggtac gcccaaacag attgtgtatt ggaagcaatg      300

gctttccttg aagaatccca tcccggaatc tttgaaaatt cgtgtcttga aacgatggag      360

gtgattcagc agacaagagt ggacaaacta acacaaggcc gacaaactta tgattggacc      420

ttgaatagga atcaacctgc cgcaacagca cttgctaata cgattgaagt attcagatca      480

aatggtctga cttccaatga atcggggaga ttgatggact tcctcaaaga tgtcatggag      540

tccatgaaca aggaagaaat ggaaataaca acacacttcc aacggaagag aagagtaaga      600

gacaacatga caaagagaat ggtaacacag agaaccatag ggaagaagaa acaacgatta      660

aacagaaaga gctatctaat cagaacatta accctaaaca caatgaccaa ggacgctgag      720

agagggaaat tgaaacgacg agcaatcgct accccaggga tgcagataag agggtttgta      780

tattttgttg aaacactagc ccgaagaata tgtgaaaagc ttgaacaatc aggattgcca      840

gttggcggta atgagaaaaa ggccaaactg gctaatgtcg tcagaaaaat gatgactaat      900

tcccaagaca ctgaactctc cttcaccatc actggggaca ataccaaatg gaatgaaaat      960

cagaacccac gcatattcct ggcaatgatc acatacataa ctagaaacca gccagaatgg     1020

ttcagaaatg ttctaagcat tgcaccgatt atgttctcaa ataaaatggc aagactgggg     1080

aaaggatata tgtttgaaag caaaagtatg aaattgagaa ctcaaatacc agcagaaatg     1140

ctagcaagca ttgacctgaa atatttcaat gattcaacaa aaaagaaaat tgaagaaata     1200

aggcctcttc tggttgacgg gactgcttca ctgagtcctg gcatgatgat gggaatgttc     1260

aacatgttga gcactgtgct gggtgtatcc atattaaacc tgggccagag gaaatacaca     1320

aagaccacat actggtggga tggtctgcaa tcatccgatg actttgcttt gatagtgaat     1380

gcgcctaatc atgaaggaat acaagctgga gtagacagat tctatagaac ttgcaaactg     1440

gtcgggatca acatgagcaa aaagaagtcc tacataaata gaactggaac attcgaattc     1500

acaagctttt tctaccggta tggttttgta gccaatttca gcatggaact acccagtttt     1560

ggggtttccg gaataaatga atctgcagac atgagcattg gagtgacagt catcaaaaac     1620

aacatgataa ataatgatct cggtcctgcc acggcacaaa tggcactcca actcttcatt     1680

aaggattatc ggtacacata ccggtgccat agaggtgata cccagataca aaccagaaga     1740

tcttttgagt tgaagaagct ttgggggcag actcgatcaa agactggtct actggtatca     1800

gatgggggtc caaacctata taacatcaga aacctacaca tcccggaagt ctgtttaaaa     1860

tgggagctaa tggatgaaga ttataagggg aggctatgca atccattgaa tcctttcgtt     1920

agtcacaaag aaattgaatc agtcaacagt gcagtagtaa tgtctgcgca tggccctgcc     1980

aaaagcatgg agtatgatgc tgttactaca acacattctt ggatacccaa gaggaaccgg     2040

tccatattga acacaagcca aaggggaata ctcgaagatg agcagatgta tcagaaatgc     2100

tgcaacctgt ttgaaaaatt cttccccagc agctcataca gaagaccagt cggaatttct     2160

agtatggttg aggccatggt gtccagggcc cgcattgatg cacgaattga cttcgaatct     2220

ggacggataa agaaggatga gttcgctgag atcatgaaga tctgttccac cattgaagag     2280

ctcagacggc aaaaatagtg aatttagctt gatcttcatg aaaaaatgcc ttgtttctac     2340

t                                                                     2341


<210>  4
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized - mutant PB1 based on A/equine/Ohio/1/2003
       H3N8 EIV

<400>  4

Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Val Pro Ala Gln Asn 
1               5                   10                  15      


Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          


Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              


Tyr Ser Glu Lys Gly Lys Trp Thr Thr Asn Thr Glu Ile Gly Ala Pro 
    50                  55                  60                  


Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  


Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Glu 
                85                  90                  95      


Glu Ser His Pro Gly Ile Phe Glu Asn Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         


Val Ile Gln Gln Thr Arg Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             


Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 


Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ser Asn Glu Ser 
145                 150                 155                 160 


Gly Arg Leu Met Asp Phe Leu Lys Asp Val Met Glu Ser Met Asn Lys 
                165                 170                 175     


Glu Glu Met Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         


Asp Asn Met Thr Lys Arg Met Val Thr Gln Arg Thr Ile Gly Lys Lys 
        195                 200                 205             


Lys Gln Arg Leu Asn Arg Lys Ser Tyr Leu Ile Arg Thr Leu Thr Leu 
    210                 215                 220                 


Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 


Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     


Thr Leu Ala Arg Arg Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         


Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             


Met Met Thr Asn Ser Gln Asp Thr Glu Leu Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 


Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Ile Phe Leu Ala 
305                 310                 315                 320 


Met Ile Thr Tyr Ile Thr Arg Asn Gln Pro Glu Trp Phe Arg Asn Val 
                325                 330                 335     


Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         


Lys Gly Tyr Met Phe Glu Ser Lys Ser Met Lys Leu Arg Thr Gln Ile 
        355                 360                 365             


Pro Ala Glu Met Leu Ala Ser Ile Asp Leu Lys Tyr Phe Asn Asp Ser 
    370                 375                 380                 


Thr Lys Lys Lys Ile Glu Glu Ile Arg Pro Leu Leu Val Asp Gly Thr 
385                 390                 395                 400 


Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     


Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Arg Lys Tyr Thr 
            420                 425                 430         


Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             


Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 


Arg Phe Tyr Arg Thr Cys Lys Leu Val Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 


Lys Ser Tyr Ile Asn Arg Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     


Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         


Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             


Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 


Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 


Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Leu 
                565                 570                 575     


Lys Lys Leu Trp Gly Gln Thr Arg Ser Lys Thr Gly Leu Leu Val Ser 
            580                 585                 590         


Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             


Val Cys Leu Lys Trp Glu Leu Met Asp Glu Asp Tyr Lys Gly Arg Leu 
    610                 615                 620                 


Cys Asn Pro Leu Asn Pro Phe Val Ser His Lys Glu Ile Glu Ser Val 
625                 630                 635                 640 


Asn Ser Ala Val Val Met Ser Ala His Gly Pro Ala Lys Ser Met Glu 
                645                 650                 655     


Tyr Asp Ala Val Thr Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         


Ser Ile Leu Asn Thr Ser Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             


Tyr Gln Lys Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 


Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 


Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     


Lys Asp Glu Phe Ala Glu Ile Met Lys Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         


Leu Arg Arg Gln Lys 
        755         


<210>  5
<211>  2341
<212>  DNA
<213>  Influenza A virus

<400>  5
agcgaaagca ggtcaaatat attcaatatg gagagaataa aagaactgag agatctgatg       60

ttacaatccc gcacccgcga gatactaaca aaaactactg tggaccacat ggccataatc      120

aagaaataca catcaggaag acaagagaag aaccctgcac ttaggatgaa atggatgatg      180

gcaatgaaat acccaatcac ggcagataag aggataatgg agatgattcc tgagagaaat      240

gaacagggac aaaccctttg gagcaaaacg aacgatgctg gctcagaccg cgtaatggta      300

tcacctctgg cagtgacatg gtggaatagg aatggaccaa caacaagcac aattcattat      360

ccaaaagtct acaaaactta ttttgaaaag gttgaaagat tgaaacacgg aacctttggc      420

cccgttcatt ttaggaatca agtcaagata agacgaagag ttgatgtaaa ccctggtcac      480

gcggacctca gtgccaaaga agcacaagat gtgatcatgg aagttgtttt cccaaatgaa      540

gtgggagcca gaattctaac atcggaatca caactaacaa taaccaaaga gaaaaaggaa      600

gaacttcagg actgcaaaat tgctcccttg atggtagcat acatgctaga aagagagttg      660

gtccgaaaaa caaggttcct cccagtagca ggcggaacaa gcagtgtata cattgaagtg      720

ttgcatctga ctcagggaac atgctgggag caaatgtaca ccccaggagg agaagttaga      780

aacgatgata ttgatcaaag tttaattatt gcagcacgga acatagtgag aagagcaaca      840

gtatcagcag atccactagc atccctactg gaaatgtgcc acagtacaca gattggtgga      900

ataaggatgg tagacatcct taagcagaat ccaacagagg aacaagctgt ggatatatgc      960

aaagcagcaa tgggattgag aattagctca tcattcagct ttggtggatt caccttcaaa     1020

agaacaagtg gatcatcagt caagagagaa gaagaaatgc ttacgggcaa ccttcaaaca     1080

ttgaaaataa gaatgcatga gggctatgaa gaattcacaa tggtcggaag aagagcaaca     1140

gctattctca gaaaggcaac cagaagattg attcaattga tagtaagtgg gagagatgaa     1200

caatcaattg ctgaagcaat aattgtagcc atggtgtttt cgcaagaaga ttgcatgata     1260

aaagcagttc gaggcgattt gaactttgtt aatagagcaa atcagcgttt gaaccccatg     1320

catcaactct tgaggcattt ccaaaaagat gcaaaagtgc ttttccaaaa ttggggaatt     1380

gaacccatcg acaatgtaat ggggatgatt ggaatattgc ctgacatgac cccaagcacc     1440

gagatgtcat tgagaggagt gagagtcagc aaaatgggag tggatgagta ctccagcact     1500

gagagagtgg tggtgagcat tgaccgtttt ttaagagttc gggatcaaag gggaaacata     1560

ctactgtccc ctgaagaagt cagtgaaaca caaggaacgg aaaagctgac aataatttat     1620

tcgtcatcaa tgatgtggga gattaatggt cccgaatcag tgttggtcaa tacttatcaa     1680

tggatcatca ggaactggga aattgtaaaa attcagtggt cacaggaccc cacaatgtta     1740

tacaataaga tagaatttga gccattccaa tccctggtcc ctagggccac cagaagccaa     1800

tacagcggtt tcgtaagaac cctgtttcag caaatgcgag atgtacttgg aacatttgat     1860

actgctcaaa taataaaact cctccctttt gccgctgctc ctccggaaca gagtaggatg     1920

cagttctctt ctttgactgt taatgtaaga ggttcgggaa tgaggatact tgtaagaggc     1980

aattccccag tgttcaacta caataaagcc actaaaaggc tcacagtcct cggaaaggat     2040

gcaggtgcgc ttactgagga cccagatgaa ggtacggctg gagtagaatc tgctgttcta     2100

agagggtttc tcattttagg taaagaaaac aagagatatg gcccagcact aagcatcaat     2160

gaactaagca aacttgcaaa aggggagaaa gccaatgtac taattgggca aggggacgta     2220

gtgttggtaa tgaaacggaa acgtgactct agcatactta ctgacagcca gacagcgacc     2280

aaaaggattc ggatggccat caattagtgt tgaattgttt aaaaacgacc ttgtttctac     2340

t                                                                     2341


<210>  6
<211>  759
<212>  PRT
<213>  Influenza A virus

<400>  6

Met Glu Arg Ile Lys Glu Leu Arg Asp Leu Met Leu Gln Ser Arg Thr 
1               5                   10                  15      


Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 
            20                  25                  30          


Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys 
        35                  40                  45              


Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Met 
    50                  55                  60                  


Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys 
65                  70                  75                  80  


Thr Asn Asp Ala Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 
                85                  90                  95      


Thr Trp Trp Asn Arg Asn Gly Pro Thr Thr Ser Thr Ile His Tyr Pro 
            100                 105                 110         


Lys Val Tyr Lys Thr Tyr Phe Glu Lys Val Glu Arg Leu Lys His Gly 
        115                 120                 125             


Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg 
    130                 135                 140                 


Val Asp Val Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln 
145                 150                 155                 160 


Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile 
                165                 170                 175     


Leu Thr Ser Glu Ser Gln Leu Thr Ile Thr Lys Glu Lys Lys Glu Glu 
            180                 185                 190         


Leu Gln Asp Cys Lys Ile Ala Pro Leu Met Val Ala Tyr Met Leu Glu 
        195                 200                 205             


Arg Glu Leu Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr 
    210                 215                 220                 


Ser Ser Val Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp 
225                 230                 235                 240 


Glu Gln Met Tyr Thr Pro Gly Gly Glu Val Arg Asn Asp Asp Ile Asp 
                245                 250                 255     


Gln Ser Leu Ile Ile Ala Ala Arg Asn Ile Val Arg Arg Ala Thr Val 
            260                 265                 270         


Ser Ala Asp Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln 
        275                 280                 285             


Ile Gly Gly Ile Arg Met Val Asp Ile Leu Lys Gln Asn Pro Thr Glu 
    290                 295                 300                 


Glu Gln Ala Val Asp Ile Cys Lys Ala Ala Met Gly Leu Arg Ile Ser 
305                 310                 315                 320 


Ser Ser Phe Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Ser Gly Ser 
                325                 330                 335     


Ser Val Lys Arg Glu Glu Glu Met Leu Thr Gly Asn Leu Gln Thr Leu 
            340                 345                 350         


Lys Ile Arg Met His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Arg 
        355                 360                 365             


Arg Ala Thr Ala Ile Leu Arg Lys Ala Thr Arg Arg Leu Ile Gln Leu 
    370                 375                 380                 


Ile Val Ser Gly Arg Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val 
385                 390                 395                 400 


Ala Met Val Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly 
                405                 410                 415     


Asp Leu Asn Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His 
            420                 425                 430         


Gln Leu Leu Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn 
        435                 440                 445             


Trp Gly Ile Glu Pro Ile Asp Asn Val Met Gly Met Ile Gly Ile Leu 
    450                 455                 460                 


Pro Asp Met Thr Pro Ser Thr Glu Met Ser Leu Arg Gly Val Arg Val 
465                 470                 475                 480 


Ser Lys Met Gly Val Asp Glu Tyr Ser Ser Thr Glu Arg Val Val Val 
                485                 490                 495     


Ser Ile Asp Arg Phe Leu Arg Val Arg Asp Gln Arg Gly Asn Ile Leu 
            500                 505                 510         


Leu Ser Pro Glu Glu Val Ser Glu Thr Gln Gly Thr Glu Lys Leu Thr 
        515                 520                 525             


Ile Ile Tyr Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser 
    530                 535                 540                 


Val Leu Val Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Ile Val 
545                 550                 555                 560 


Lys Ile Gln Trp Ser Gln Asp Pro Thr Met Leu Tyr Asn Lys Ile Glu 
                565                 570                 575     


Phe Glu Pro Phe Gln Ser Leu Val Pro Arg Ala Thr Arg Ser Gln Tyr 
            580                 585                 590         


Ser Gly Phe Val Arg Thr Leu Phe Gln Gln Met Arg Asp Val Leu Gly 
        595                 600                 605             


Thr Phe Asp Thr Ala Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala 
    610                 615                 620                 


Pro Pro Glu Gln Ser Arg Met Gln Phe Ser Ser Leu Thr Val Asn Val 
625                 630                 635                 640 


Arg Gly Ser Gly Met Arg Ile Leu Val Arg Gly Asn Ser Pro Val Phe 
                645                 650                 655     


Asn Tyr Asn Lys Ala Thr Lys Arg Leu Thr Val Leu Gly Lys Asp Ala 
            660                 665                 670         


Gly Ala Leu Thr Glu Asp Pro Asp Glu Gly Thr Ala Gly Val Glu Ser 
        675                 680                 685             


Ala Val Leu Arg Gly Phe Leu Ile Leu Gly Lys Glu Asn Lys Arg Tyr 
    690                 695                 700                 


Gly Pro Ala Leu Ser Ile Asn Glu Leu Ser Lys Leu Ala Lys Gly Glu 
705                 710                 715                 720 


Lys Ala Asn Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys 
                725                 730                 735     


Arg Lys Arg Asp Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys 
            740                 745                 750         


Arg Ile Arg Met Ala Ile Asn 
        755                 


<210>  7
<211>  2341
<212>  DNA
<213>  Influenza A virus

<400>  7
agcgaaagca ggcaaaccat ttgaatggat gtcaatccga ctctactttt cttaaaggtg       60

ccagcgcaaa atgctataag cacaacattc ccttatactg gagatcctcc ctacagtcat      120

ggaacaggga caggatacac catggatact gtcaacagaa cacaccaata ttcagaaaaa      180

gggaaatgga caacaaacac tgagattgga gcaccacaac ttaatccaat cgatggacca      240

cttcctgaag acaatgaacc aagtgggtac gcccaaacag attgtgtatt ggaagcaatg      300

gctttccttg aagaatccca tcccggaatc tttgaaaatt cgtgtcttga aacgatggag      360

gtgattcagc agacaagagt ggacaaacta acacaaggcc gacaaactta tgattggacc      420

ttgaatagga atcaacctgc cgcaacagca cttgctaata cgattgaagt attcagatca      480

aatggtctga cttccaatga atcggggaga ttgatggact tcctcaaaga tgtcatggag      540

tccatgaaca aggaagaaat ggaaataaca acacacttcc aacggaagag aagagtaaga      600

gacaacatga caaagagaat ggtaacacag agaaccatag ggaagaagaa acaacgatta      660

aacagaaaga gctatctaat cagaacatta accctaaaca caatgaccaa ggacgctgag      720

agagggaaat tgaaacgacg agcaatcgct accccaggga tgcagataag agggtttgta      780

tattttgttg aaacactagc ccgaagaata tgtgaaaagc ttgaacaatc aggattgcca      840

gttggcggta atgagaaaaa ggccaaactg gctaatgtcg tcagaaaaat gatgactaat      900

tcccaagaca ctgaactctc cttcaccatc actggggaca ataccaaatg gaatgaaaat      960

cagaacccac gcatattcct ggcaatgatc acatacataa ctagaaacca gccagaatgg     1020

ttcagaaatg ttctaagcat tgcaccgatt atgttctcaa ataaaatggc aagactgggg     1080

aaaggatata tgtttgaaag caaaagtatg aaattgagaa ctcaaatacc agcagaaatg     1140

ctagcaagca ttgacctgaa atatttcaat gattcaacaa aaaagaaaat tgaaaagata     1200

cgaccacttc tggttgacgg gactgcttca ctgagtcctg gcatgatgat gggaatgttc     1260

aacatgttga gcactgtgct gggtgtatcc atattaaacc tgggccagag gaaatacaca     1320

aagaccacat actggtggga tggtctgcaa tcatccgatg actttgcttt gatagtgaat     1380

gcgcctaatc atgaaggaat acaagctgga gtagacagat tctatagaac ttgcaaactg     1440

gtcgggatca acatgagcaa aaagaagtcc tacataaata gaactggaac attcgaattc     1500

acaagctttt tctaccggta tggttttgta gccaatttca gcatggaact acccagtttt     1560

ggggtttccg gaataaatga atctgcagac atgagcattg gagtgacagt catcaaaaac     1620

aacatgataa ataatgatct cggtcctgcc acggcacaaa tggcactcca actcttcatt     1680

aaggattatc ggtacacata ccggtgccat agaggtgata cccagataca aaccagaaga     1740

tcttttgagt tgaagaaact gtgggaacag actcgatcaa agactggtct actggtatca     1800

gatgggggtc caaacctata taacatcaga aacctacaca tcccggaagt ctgtttaaaa     1860

tgggagctaa tggatgaaga ttataagggg aggctatgca atccattgaa tcctttcgtt     1920

agtcacaaag aaattgaatc agtcaacagt gcagtagtaa tgtctgcgca tggccctgcc     1980

aaaagcatgg agtatgatgc tgttgcaaca acacattctt ggatccccaa gaggaaccgg     2040

tccatattga acacaagcca aaggggaata ctcgaagatg agcagatgta tcagaaatgc     2100

tgcaacctgt ttgaaaaatt cttccccagc agctcataca gaagaccagt cggaatttct     2160

agtatggttg aggccatggt gtccagggcc cgcattgatg cacgaattga cttcgaatct     2220

ggacggataa agaaggatga gttcgctgag atcatgaaga tctgttccac cattgaagag     2280

ctcagacggc aaaaatagtg aatttagctt gatcttcatg aaaaaatgcc ttgtttctac     2340

t                                                                     2341


<210>  8
<211>  757
<212>  PRT
<213>  Influenza A virus

<400>  8

Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Val Pro Ala Gln Asn 
1               5                   10                  15      


Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          


Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              


Tyr Ser Glu Lys Gly Lys Trp Thr Thr Asn Thr Glu Ile Gly Ala Pro 
    50                  55                  60                  


Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  


Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Glu 
                85                  90                  95      


Glu Ser His Pro Gly Ile Phe Glu Asn Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         


Val Ile Gln Gln Thr Arg Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             


Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 


Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ser Asn Glu Ser 
145                 150                 155                 160 


Gly Arg Leu Met Asp Phe Leu Lys Asp Val Met Glu Ser Met Asn Lys 
                165                 170                 175     


Glu Glu Met Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         


Asp Asn Met Thr Lys Arg Met Val Thr Gln Arg Thr Ile Gly Lys Lys 
        195                 200                 205             


Lys Gln Arg Leu Asn Arg Lys Ser Tyr Leu Ile Arg Thr Leu Thr Leu 
    210                 215                 220                 


Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 


Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     


Thr Leu Ala Arg Arg Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         


Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             


Met Met Thr Asn Ser Gln Asp Thr Glu Leu Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 


Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Ile Phe Leu Ala 
305                 310                 315                 320 


Met Ile Thr Tyr Ile Thr Arg Asn Gln Pro Glu Trp Phe Arg Asn Val 
                325                 330                 335     


Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         


Lys Gly Tyr Met Phe Glu Ser Lys Ser Met Lys Leu Arg Thr Gln Ile 
        355                 360                 365             


Pro Ala Glu Met Leu Ala Ser Ile Asp Leu Lys Tyr Phe Asn Asp Ser 
    370                 375                 380                 


Thr Lys Lys Lys Ile Glu Lys Ile Arg Pro Leu Leu Val Asp Gly Thr 
385                 390                 395                 400 


Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     


Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Arg Lys Tyr Thr 
            420                 425                 430         


Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             


Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 


Arg Phe Tyr Arg Thr Cys Lys Leu Val Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 


Lys Ser Tyr Ile Asn Arg Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     


Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         


Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             


Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 


Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 


Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Leu 
                565                 570                 575     


Lys Lys Leu Trp Glu Gln Thr Arg Ser Lys Thr Gly Leu Leu Val Ser 
            580                 585                 590         


Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             


Val Cys Leu Lys Trp Glu Leu Met Asp Glu Asp Tyr Lys Gly Arg Leu 
    610                 615                 620                 


Cys Asn Pro Leu Asn Pro Phe Val Ser His Lys Glu Ile Glu Ser Val 
625                 630                 635                 640 


Asn Ser Ala Val Val Met Ser Ala His Gly Pro Ala Lys Ser Met Glu 
                645                 650                 655     


Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         


Ser Ile Leu Asn Thr Ser Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             


Tyr Gln Lys Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 


Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 


Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     


Lys Asp Glu Phe Ala Glu Ile Met Lys Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         


Leu Arg Arg Gln Lys 
        755         


<210>  9
<211>  2233
<212>  DNA
<213>  Influenza A virus

<400>  9
agcgaaagca ggtactgatc caaaatggaa gactttgtgc gacagtgctt caatccaatg       60

atcgtcgagc ttgcggaaaa ggcaatgaaa gaatatggag aggacccgaa aatcgaaaca      120

aacaaatttg cagcaatatg cactcacttg gaagtctgct tcatgtactc ggatttccac      180

tttattaatg aactgggtga gtcagtggtc atagagtctg gtgacccaaa tgctcttttg      240

aaacacagat ttgaaatcat tgaggggaga gatcgaacaa tggcatggac agtagtaaac      300

agcatctgca acaccacaag agctgaaaaa cctaaatttc ttccagattt atacgactat      360

aaggagaaca gatttgttga aattggtgtg acaaggagag aagttcacat atactacctg      420

gagaaggcca acaaaataaa gtctgagaaa acacatatcc acattttctc atttacagga      480

gaggaaatgg ctacaaaagc ggactatact cttgatgaag agagtagagc caggatcaag      540

accagactat tcactataag acaagaaatg gccagtagag gcctctggga ttcctttcgt      600

cagtccgaga gaggcgaaga gacaattgaa gaaagatttg aaatcacagg gacgatgcgc      660

aagcttgcca attacagtct cccaccgaac ttctccagcc ttgaaaattt tagagtctat      720

gtggatggat tcgaaccgaa cggcttcatt gagagtaagc tttctcaaat gtccaaagaa      780

gtaaatgcca gaatcgaacc attttcaaag acaacacccc gaccactcaa aatgccaggt      840

ggtccaccct gccatcagcg atctaaattc ttgctaatgg atgctctgaa actgagcatt      900

gaggacccaa gtcacgaggg agagggaata ccactatatg atgcaatcaa atgcatgaaa      960

actttctttg gatggaaaga gcccagtatt gttaaaccac atgaaaaggg tataaacccg     1020

aactatctcc aaacttggaa gcaagtatta gaagaaatac aagaccttga gaacgaagaa     1080

aggaccccca agaccaagaa tatgaaaaaa acaagccaat tgaaatgggc actaggtgaa     1140

aatatggcac cagagaaagt ggattttgag gattgtaaag acatcagtga tttaaaacag     1200

tatgacagtg atgagccaga aacaaggtct cttgcaagtt ggattcaaag tgagttcaac     1260

aaagcttgtg agctgacaga ttcaagctgg atagagctcg atgaaattgg ggaggatgtc     1320

gccccaatag aatacattgc gagcatgagg agaaattatt ttactgctga gatttcccat     1380

tgtagagcaa cagaatatat aatgaaagga gtgtacatca acactgctct actcaatgca     1440

tcctgtgctg cgatggatga atttcaatta attccgatga taagtaaatg caggaccaaa     1500

gaagggagaa ggaaaacaaa tttatatgga ttcataataa agggaagatc ccatttaaga     1560

aatgatactg acgtggtgaa ctttgtaagt atggaatttt ctctcactga tccaagattt     1620

gagccacaca aatgggaaaa atactgcgtt ctagaaattg gagacatgct tctaagaact     1680

gctgtaggtc aagtgtcaag acccatgttt ttgtatgtaa ggacaaatgg aacctctaaa     1740

attaaaatga aatggggaat ggaaatgagg cgctgcctcc ttcagtctct gcaacagatt     1800

gaaagcatga tcgaagctga gtcctcggtc aaagaaaagg acatgaccaa agaatttttt     1860

gagaacaaat cagagacatg gcctatagga gagtccccca aaggagtgga agagggctca     1920

atcgggaagg tttgcaggac cttattagca aaatctgtgt ttaacagttt gtatgcatct     1980

ccacaactgg aagggttttc agctgaatct aggaaattac ttctcattgt tcaggctctt     2040

agggataacc tggaacctgg aacatttgat attggggggt tatatgaatc aattgaggag     2100

tgcctgatta atgatccctg ggttttgctt aatgcatctt ggttcaactc cttccttaca     2160

catgcactga agtagttgtg gcaatgctac tatttgctat ccatactgtc caaaaaagta     2220

ccttgtttct act                                                        2233


<210>  10
<211>  716
<212>  PRT
<213>  Influenza A virus

<400>  10

Met Glu Asp Phe Val Arg Gln Cys Phe Asn Pro Met Ile Val Glu Leu 
1               5                   10                  15      


Ala Glu Lys Ala Met Lys Glu Tyr Gly Glu Asp Pro Lys Ile Glu Thr 
            20                  25                  30          


Asn Lys Phe Ala Ala Ile Cys Thr His Leu Glu Val Cys Phe Met Tyr 
        35                  40                  45              


Ser Asp Phe His Phe Ile Asn Glu Leu Gly Glu Ser Val Val Ile Glu 
    50                  55                  60                  


Ser Gly Asp Pro Asn Ala Leu Leu Lys His Arg Phe Glu Ile Ile Glu 
65                  70                  75                  80  


Gly Arg Asp Arg Thr Met Ala Trp Thr Val Val Asn Ser Ile Cys Asn 
                85                  90                  95      


Thr Thr Arg Ala Glu Lys Pro Lys Phe Leu Pro Asp Leu Tyr Asp Tyr 
            100                 105                 110         


Lys Glu Asn Arg Phe Val Glu Ile Gly Val Thr Arg Arg Glu Val His 
        115                 120                 125             


Ile Tyr Tyr Leu Glu Lys Ala Asn Lys Ile Lys Ser Glu Lys Thr His 
    130                 135                 140                 


Ile His Ile Phe Ser Phe Thr Gly Glu Glu Met Ala Thr Lys Ala Asp 
145                 150                 155                 160 


Tyr Thr Leu Asp Glu Glu Ser Arg Ala Arg Ile Lys Thr Arg Leu Phe 
                165                 170                 175     


Thr Ile Arg Gln Glu Met Ala Ser Arg Gly Leu Trp Asp Ser Phe Arg 
            180                 185                 190         


Gln Ser Glu Arg Gly Glu Glu Thr Ile Glu Glu Arg Phe Glu Ile Thr 
        195                 200                 205             


Gly Thr Met Arg Lys Leu Ala Asn Tyr Ser Leu Pro Pro Asn Phe Ser 
    210                 215                 220                 


Ser Leu Glu Asn Phe Arg Val Tyr Val Asp Gly Phe Glu Pro Asn Gly 
225                 230                 235                 240 


Phe Ile Glu Ser Lys Leu Ser Gln Met Ser Lys Glu Val Asn Ala Arg 
                245                 250                 255     


Ile Glu Pro Phe Ser Lys Thr Thr Pro Arg Pro Leu Lys Met Pro Gly 
            260                 265                 270         


Gly Pro Pro Cys His Gln Arg Ser Lys Phe Leu Leu Met Asp Ala Leu 
        275                 280                 285             


Lys Leu Ser Ile Glu Asp Pro Ser His Glu Gly Glu Gly Ile Pro Leu 
    290                 295                 300                 


Tyr Asp Ala Ile Lys Cys Met Lys Thr Phe Phe Gly Trp Lys Glu Pro 
305                 310                 315                 320 


Ser Ile Val Lys Pro His Glu Lys Gly Ile Asn Pro Asn Tyr Leu Gln 
                325                 330                 335     


Thr Trp Lys Gln Val Leu Glu Glu Ile Gln Asp Leu Glu Asn Glu Glu 
            340                 345                 350         


Arg Thr Pro Lys Thr Lys Asn Met Lys Lys Thr Ser Gln Leu Lys Trp 
        355                 360                 365             


Ala Leu Gly Glu Asn Met Ala Pro Glu Lys Val Asp Phe Glu Asp Cys 
    370                 375                 380                 


Lys Asp Ile Ser Asp Leu Lys Gln Tyr Asp Ser Asp Glu Pro Glu Thr 
385                 390                 395                 400 


Arg Ser Leu Ala Ser Trp Ile Gln Ser Glu Phe Asn Lys Ala Cys Glu 
                405                 410                 415     


Leu Thr Asp Ser Ser Trp Ile Glu Leu Asp Glu Ile Gly Glu Asp Val 
            420                 425                 430         


Ala Pro Ile Glu Tyr Ile Ala Ser Met Arg Arg Asn Tyr Phe Thr Ala 
        435                 440                 445             


Glu Ile Ser His Cys Arg Ala Thr Glu Tyr Ile Met Lys Gly Val Tyr 
    450                 455                 460                 


Ile Asn Thr Ala Leu Leu Asn Ala Ser Cys Ala Ala Met Asp Glu Phe 
465                 470                 475                 480 


Gln Leu Ile Pro Met Ile Ser Lys Cys Arg Thr Lys Glu Gly Arg Arg 
                485                 490                 495     


Lys Thr Asn Leu Tyr Gly Phe Ile Ile Lys Gly Arg Ser His Leu Arg 
            500                 505                 510         


Asn Asp Thr Asp Val Val Asn Phe Val Ser Met Glu Phe Ser Leu Thr 
        515                 520                 525             


Asp Pro Arg Phe Glu Pro His Lys Trp Glu Lys Tyr Cys Val Leu Glu 
    530                 535                 540                 


Ile Gly Asp Met Leu Leu Arg Thr Ala Val Gly Gln Val Ser Arg Pro 
545                 550                 555                 560 


Met Phe Leu Tyr Val Arg Thr Asn Gly Thr Ser Lys Ile Lys Met Lys 
                565                 570                 575     


Trp Gly Met Glu Met Arg Arg Cys Leu Leu Gln Ser Leu Gln Gln Ile 
            580                 585                 590         


Glu Ser Met Ile Glu Ala Glu Ser Ser Val Lys Glu Lys Asp Met Thr 
        595                 600                 605             


Lys Glu Phe Phe Glu Asn Lys Ser Glu Thr Trp Pro Ile Gly Glu Ser 
    610                 615                 620                 


Pro Lys Gly Val Glu Glu Gly Ser Ile Gly Lys Val Cys Arg Thr Leu 
625                 630                 635                 640 


Leu Ala Lys Ser Val Phe Asn Ser Leu Tyr Ala Ser Pro Gln Leu Glu 
                645                 650                 655     


Gly Phe Ser Ala Glu Ser Arg Lys Leu Leu Leu Ile Val Gln Ala Leu 
            660                 665                 670         


Arg Asp Asn Leu Glu Pro Gly Thr Phe Asp Ile Gly Gly Leu Tyr Glu 
        675                 680                 685             


Ser Ile Glu Glu Cys Leu Ile Asn Asp Pro Trp Val Leu Leu Asn Ala 
    690                 695                 700                 


Ser Trp Phe Asn Ser Phe Leu Thr His Ala Leu Lys 
705                 710                 715     


<210>  11
<211>  1762
<212>  DNA
<213>  Influenza A virus

<400>  11
agcaaaagca ggggatattt ctgtcaatca tgaagacaac cattattttg atactactga       60

cccattgggc ctacagtcaa aacccaatca gtggcaacaa cacagccaca ttgtgtctgg      120

gacgccatgc agtagcaaat ggaacattgg taaaaacaat aagtgatgat caaattgagg      180

tgacaaatgc tacagaatta gttcagagca tttcaacggg gaaaatatgc aacaactcat      240

atagaattct agatggaaga aattgcacat taatagatgc aatgctagga gacccccact      300

gtgacgcctt tcagtatgag aattgggacc tctttataga aagaagcagc gctttcagca      360

attgctaccc atatgacatc cctgactatg catcgctccg atccattgta gcatcctcag      420

gaacattgga attcacagca gagggattca catggacagg tgtcactcaa aacggaataa      480

gtggagcctg caaaagggga tcagccgata gtttctttag ccgactgaat tggctaacaa      540

aatctggaag ctcttacccc acattgaatg tgacaatgcc taacaataaa aatttcgaca      600

agctatacat ctgggggatt catcacccga gctcaaatca agagcagaca aaattgtaca      660

tccaagaatc aggacgagta acagtctcaa caaaaagaag tcaacaaaca ataatcccta      720

acatcggatc tagaccgtgg gtcagaggtc aatcaggcag gataagcata tactggacca      780

ttgtaaaacc tggagatatc ctaatgataa acagtaatgg caacttagtt gcaccgcggg      840

gatattttaa attgaaaaca gggaaaagct ctgtaatgag atcagatgta cccatagaaa      900

tttgtgtgtc tgaatgtatt acaccaaatg gaagcatctc caacgacaag ccattccaaa      960

atgtgaacaa agttacatat ggaaaatgcc ccaagtatat caggcaaaac actttaaagc     1020

tggccactgg gatgaggaat gtaccagaaa agcaaatcag aggaatcttc ggagcaatag     1080

cgggattcat cgaaaacggc tgggaaggaa tggttgatgg gtggtatggg ttccgatatc     1140

aaaactctga aggaacaggg caagctgcag atctaaagag cactcaagca gccatcgacc     1200

agattaatgg aaagttaaac agagtgattg aaagaaccaa tgagaaattc catcaaatag     1260

agaaggaatt ctcagaagta gaaggaagaa ttcaggactt ggagaaatat gtagaagaca     1320

ccaaaataga cctatggtcc tacaatgcag aattgctggt ggctctagaa aatcaacata     1380

caattgactt aacagatgca gaaatgaata aattatttga gaagactaga cgccagttaa     1440

gagaaaacgc agaagacatg ggaggtggat gtttcaagat ttaccacaaa tgtgataatg     1500

catgcattgg atcaataaga aatgggacat atgaccatta catatacaga gatgaagcat     1560

taaacaaccg atttcagatc aaaggtgtag agttgaaatc aggctacaaa gattggatac     1620

tgtggatttc attcgccata tcatgcttct taatttgcgt tgttctattg ggtttcatta     1680

tgtgggcttg ccaaaaaggc aacatcagat gcaacatttg catttgagta aactgatagt     1740

taaaaacacc cttgtttcta ct                                              1762


<210>  12
<211>  565
<212>  PRT
<213>  Influenza A virus

<400>  12

Met Lys Thr Thr Ile Ile Leu Ile Leu Leu Thr His Trp Ala Tyr Ser 
1               5                   10                  15      


Gln Asn Pro Ile Ser Gly Asn Asn Thr Ala Thr Leu Cys Leu Gly Arg 
            20                  25                  30          


His Ala Val Ala Asn Gly Thr Leu Val Lys Thr Ile Ser Asp Asp Gln 
        35                  40                  45              


Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ile Ser Thr Gly 
    50                  55                  60                  


Lys Ile Cys Asn Asn Ser Tyr Arg Ile Leu Asp Gly Arg Asn Cys Thr 
65                  70                  75                  80  


Leu Ile Asp Ala Met Leu Gly Asp Pro His Cys Asp Ala Phe Gln Tyr 
                85                  90                  95      


Glu Asn Trp Asp Leu Phe Ile Glu Arg Ser Ser Ala Phe Ser Asn Cys 
            100                 105                 110         


Tyr Pro Tyr Asp Ile Pro Asp Tyr Ala Ser Leu Arg Ser Ile Val Ala 
        115                 120                 125             


Ser Ser Gly Thr Leu Glu Phe Thr Ala Glu Gly Phe Thr Trp Thr Gly 
    130                 135                 140                 


Val Thr Gln Asn Gly Ile Ser Gly Ala Cys Lys Arg Gly Ser Ala Asp 
145                 150                 155                 160 


Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Ser Ser Tyr 
                165                 170                 175     


Pro Thr Leu Asn Val Thr Met Pro Asn Asn Lys Asn Phe Asp Lys Leu 
            180                 185                 190         


Tyr Ile Trp Gly Ile His His Pro Ser Ser Asn Gln Glu Gln Thr Lys 
        195                 200                 205             


Leu Tyr Ile Gln Glu Ser Gly Arg Val Thr Val Ser Thr Lys Arg Ser 
    210                 215                 220                 


Gln Gln Thr Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg Gly 
225                 230                 235                 240 


Gln Ser Gly Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly Asp 
                245                 250                 255     


Ile Leu Met Ile Asn Ser Asn Gly Asn Leu Val Ala Pro Arg Gly Tyr 
            260                 265                 270         


Phe Lys Leu Lys Thr Gly Lys Ser Ser Val Met Arg Ser Asp Val Pro 
        275                 280                 285             


Ile Glu Ile Cys Val Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile Ser 
    290                 295                 300                 


Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Val Thr Tyr Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Ile Arg Gln Asn Thr Leu Lys Leu Ala Thr Gly Met Arg 
                325                 330                 335     


Asn Val Pro Glu Lys Gln Ile Arg Gly Ile Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe 
        355                 360                 365             


Arg Tyr Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Val Ile 
385                 390                 395                 400 


Glu Arg Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser Glu 
                405                 410                 415     


Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys 
            420                 425                 430         


Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn 
        435                 440                 445             


Gln His Thr Ile Asp Leu Thr Asp Ala Glu Met Asn Lys Leu Phe Glu 
    450                 455                 460                 


Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Gly Gly 
465                 470                 475                 480 


Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser Ile 
                485                 490                 495     


Arg Asn Gly Thr Tyr Asp His Tyr Ile Tyr Arg Asp Glu Ala Leu Asn 
            500                 505                 510         


Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys Asp 
        515                 520                 525             


Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Ile Cys Val 
    530                 535                 540                 


Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile Arg 
545                 550                 555                 560 


Cys Asn Ile Cys Ile 
                565 


<210>  13
<211>  1565
<212>  DNA
<213>  Influenza A virus

<400>  13
agcaaaagca gggtagataa tcactcactg agtgacatca aagtcatggc gtctcaaggc       60

accaaacgat cctatgaaca gatggaaact gatggggaac gccagaatgc aactgaaatc      120

agagcatctg tcggaaggat ggtgggagga atcggccggt tttatgttca gatgtgtact      180

gagcttaaac taaacgacca tgaagggcgg ctgattcaga acagcataac aatagaaagg      240

atggtacttt cggcattcga cgaaagaaga aacaagtatc tcgaggagca tcccagtgct      300

gggaaagacc ctaagaaaac gggaggcccg atatacagaa ggaaagatgg gaaatggatg      360

agggaactca tcctccatga taaagaagaa atcatgagaa tctggcgtca ggccaacaat      420

ggtgaagacg ctactgctgg tcttactcat atgatgatct ggcactccaa tctcaatgac      480

accacatacc aaagaacaag ggctcttgtt cggactggga tggatcccag aatgtgctct      540

ctgatgcaag gctcaaccct cccacggaga tctggagccg ctggtgctgc agtaaaaggt      600

gttggaacaa tggtaatgga actcatcaga atgatcaaac gcggaataaa tgatcggaat      660

ttctggagag gtgaaaatgg tcgaagaacc agaattgctt atgaaagaat gtgcaatatc      720

ctcaaaggga aatttcagac agcagcacaa cgggctatga tggaccaggt gagggaaggc      780

cgcaatcctg gaaacgctga gattgaggat ctcattttct tggcacgatc agcacttatt      840

ttgagaggat cagtagccca taaatcatgc ctacctgcct gtgtttatgg ccttgcagta      900

accagtgggt atgactttga gaaggaagga tactctctgg ttggaattga tcctttcaaa      960

ctactccaga acagtcaaat tttcagtcta atcagaccaa aagaaaaccc agcacacaag     1020

agccagttgg tgtggatggc atgccattct gcagcatttg aggacctgag agttttaaat     1080

ttcattagag gaaccaaagt aatcccaaga ggacagttaa caaccagagg agttcaaata     1140

gcttcaaatg aaaacatgga gacaatagat tctagcacac ttgaactgag aagcaaatat     1200

tgggcaataa ggaccagaag cggaggaaac accagtcaac agagagcatc tgcaggacag     1260

ataagtgtgc aacctacttt ctcagtacag agaaatcttc cctttgagag agcaaccatt     1320

atggctgcat tcactggtaa cactgaaggg aggacttccg acatgagaac ggaaatcata     1380

aggatgatgg aaaatgccaa atcagaagat gtgtctttcc aggggcgggg agtcttcgag     1440

ctctcggacg aaaaggcaac gaacccgatc gtgccttcct ttgacatgag caatgaaggg     1500

tcttatttct tcggagacaa tgctgaggag tttgacaatt aaagaaaaat acccttgttt     1560

ctact                                                                 1565


<210>  14
<211>  498
<212>  PRT
<213>  Influenza A virus

<400>  14

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Arg Met 
            20                  25                  30          


Val Gly Gly Ile Gly Arg Phe Tyr Val Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Asn Asp His Glu Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Lys Asp Gly Lys Trp Met Arg Glu Leu Ile Leu His Asp 
            100                 105                 110         


Lys Glu Glu Ile Met Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Thr Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Arg Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Gly Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Leu Ala Val Thr Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Lys Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Asn Ser Gln Ile Phe Ser Leu Ile Arg Pro Lys Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Leu Asn Phe Ile Arg Gly Thr Lys Val 
            340                 345                 350         


Ile Pro Arg Gly Gln Leu Thr Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Glu Thr Ile Asp Ser Ser Thr Leu Glu Leu Arg Ser Lys 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Ser Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Arg Ala Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Asn Ala Lys Ser Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Phe 
                485                 490                 495     


Asp Asn 
        


<210>  15
<211>  1460
<212>  DNA
<213>  Influenza A virus

<400>  15
agcaaaagca ggagtttaaa atgaatccaa atcaaaagat aatagcaatt ggatttgcat       60

cattggggat attaatcatt aatgtcattc tccatgtagt cagcattata gtaacagtac      120

tggtcctcaa taacaataga acagatctga actgcaaagg gacgatcata agagagtgca      180

atgaaacagt aagagtagaa aaaattactc aatggtataa taccagtaca attaagtaca      240

tagagagacc ttcaaatgaa tactacatga acaacactga accactttgt gaggcccaag      300

gctttgcacc attttccaaa gataatggaa tacgaattgg gtcgagaggc catgtttttg      360

tgataagaga accttttgta tcatgttcgc cctcagaatg tagaaccttt ttcctcacac      420

agggctcatt actcaatgac aaacattcta acggcacagt aaaggaccga agtccgtata      480

ggactttgat gagtgtcaga atagggcaat cacctaatgt atatcaagct aggtttgaat      540

cggtagcatg gtcagcaaca gcatgccatg atggaaaaaa atggatgaca gttggagtca      600

cagggcccga caatcaagca attgcagtag tgaactatgg aggtgttccg gttgatatta      660

ttaattcatg ggcaggggat attttaagaa cccaagaatc atcatgcacc tgcattaaag      720

gagactgtta ttgggtaatg actgatggac cggcaaatag gcaagctaaa tataggatat      780

tcaaagcaaa agatggaaga gtaattggac agactgatat aagtttcaat gggggacaca      840

tagaggagtg ttcttgttac cccaatgaag ggaaggtgga atgcatatgc agggacaatt      900

ggactggaac aaatagacca attctggtaa tatcttctga tctatcgtac acagttggat      960

atttgtgtgc tggcattccc actgacactc ctaggggaga ggatagtcaa ttcacaggct     1020

catgtacaag tcctttggga aataaaggat acggtgtaaa aggtttcggg tttcgacaag     1080

gaactgacgt atgggccgga aggacaatta gtaggacttc aagatcagga ttcgaaataa     1140

taaaaatcag gaatggttgg acacagaaca gtaaagacca aatcaggagg caagtgatta     1200

tcgatgaccc aaattggtca ggatatagcg gttctttcac attgccggtt gaactaacaa     1260

aaaagggatg tttggtcccc tgtttctggg ttgaaatgat tagaggtaaa cctgaagaaa     1320

caacaatatg gacctctagc agctccattg tgatgtgtgg agtagatcat aaaattgcca     1380

gttggtcatg gcacgatgga gctattcttc cctttgacat cgataagatg taatttacga     1440

aaaaactcct tgtttctact                                                 1460


<210>  16
<211>  470
<212>  PRT
<213>  Influenza A virus

<400>  16

Met Asn Pro Asn Gln Lys Ile Ile Ala Ile Gly Phe Ala Ser Leu Gly 
1               5                   10                  15      


Ile Leu Ile Ile Asn Val Ile Leu His Val Val Ser Ile Ile Val Thr 
            20                  25                  30          


Val Leu Val Leu Asn Asn Asn Arg Thr Asp Leu Asn Cys Lys Gly Thr 
        35                  40                  45              


Ile Ile Arg Glu Cys Asn Glu Thr Val Arg Val Glu Lys Ile Thr Gln 
    50                  55                  60                  


Trp Tyr Asn Thr Ser Thr Ile Lys Tyr Ile Glu Arg Pro Ser Asn Glu 
65                  70                  75                  80  


Tyr Tyr Met Asn Asn Thr Glu Pro Leu Cys Glu Ala Gln Gly Phe Ala 
                85                  90                  95      


Pro Phe Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Arg Gly His Val 
            100                 105                 110         


Phe Val Ile Arg Glu Pro Phe Val Ser Cys Ser Pro Ser Glu Cys Arg 
        115                 120                 125             


Thr Phe Phe Leu Thr Gln Gly Ser Leu Leu Asn Asp Lys His Ser Asn 
    130                 135                 140                 


Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Val Arg 
145                 150                 155                 160 


Ile Gly Gln Ser Pro Asn Val Tyr Gln Ala Arg Phe Glu Ser Val Ala 
                165                 170                 175     


Trp Ser Ala Thr Ala Cys His Asp Gly Lys Lys Trp Met Thr Val Gly 
            180                 185                 190         


Val Thr Gly Pro Asp Asn Gln Ala Ile Ala Val Val Asn Tyr Gly Gly 
        195                 200                 205             


Val Pro Val Asp Ile Ile Asn Ser Trp Ala Gly Asp Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ser Cys Thr Cys Ile Lys Gly Asp Cys Tyr Trp Val Met 
225                 230                 235                 240 


Thr Asp Gly Pro Ala Asn Arg Gln Ala Lys Tyr Arg Ile Phe Lys Ala 
                245                 250                 255     


Lys Asp Gly Arg Val Ile Gly Gln Thr Asp Ile Ser Phe Asn Gly Gly 
            260                 265                 270         


His Ile Glu Glu Cys Ser Cys Tyr Pro Asn Glu Gly Lys Val Glu Cys 
        275                 280                 285             


Ile Cys Arg Asp Asn Trp Thr Gly Thr Asn Arg Pro Ile Leu Val Ile 
    290                 295                 300                 


Ser Ser Asp Leu Ser Tyr Thr Val Gly Tyr Leu Cys Ala Gly Ile Pro 
305                 310                 315                 320 


Thr Asp Thr Pro Arg Gly Glu Asp Ser Gln Phe Thr Gly Ser Cys Thr 
                325                 330                 335     


Ser Pro Leu Gly Asn Lys Gly Tyr Gly Val Lys Gly Phe Gly Phe Arg 
            340                 345                 350         


Gln Gly Thr Asp Val Trp Ala Gly Arg Thr Ile Ser Arg Thr Ser Arg 
        355                 360                 365             


Ser Gly Phe Glu Ile Ile Lys Ile Arg Asn Gly Trp Thr Gln Asn Ser 
    370                 375                 380                 


Lys Asp Gln Ile Arg Arg Gln Val Ile Ile Asp Asp Pro Asn Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Thr Leu Pro Val Glu Leu Thr Lys Lys Gly 
                405                 410                 415     


Cys Leu Val Pro Cys Phe Trp Val Glu Met Ile Arg Gly Lys Pro Glu 
            420                 425                 430         


Glu Thr Thr Ile Trp Thr Ser Ser Ser Ser Ile Val Met Cys Gly Val 
        435                 440                 445             


Asp His Lys Ile Ala Ser Trp Ser Trp His Asp Gly Ala Ile Leu Pro 
    450                 455                 460                 


Phe Asp Ile Asp Lys Met 
465                 470 


<210>  17
<211>  1027
<212>  DNA
<213>  Influenza A virus

<400>  17
agcaaaagca ggtagatatt taaagatgag tcttctaacc gaggtcgaaa cgtacgttct       60

ctctatcgta ccatcaggcc ccctcaaagc cgagatcgcg cagagacttg aagatgtctt      120

tgcagggaag aacaccgatc ttgaggcact catggaatgg ctaaagacaa gaccaatcct      180

gtcacctctg actaaaggga ttttaggatt tgtattcacg ctcaccgtgc ccagtgagcg      240

aggactgcag cgtagacgct ttgtccaaaa tgcccttagt ggaaacggag atccaaacaa      300

catggacaga gcagtaaaac tgtacaggaa gcttaaaaga gaaataacat tccatggggc      360

aaaagaggtg gcactcagct attccactgg tgcactagcc agctgcatgg gactcatata      420

caacagaatg ggaactgtta caaccgaagt ggcatttggc ctggtatgcg ccacatgtga      480

acagattgct gattcccagc atcgatctca caggcagatg gtgacaacaa ccaacccatt      540

aatcagacat gaaaacagaa tggtattagc cagtaccacg gctaaagcca tggaacagat      600

ggcaggatcg agtgagcagg cagcagaggc catggaggtt gctagtaggg ctaggcagat      660

ggtacaggca atgagaacca ttgggaccca ccctagctcc agtgccggtt tgaaagatga      720

tctcattgaa aatttacagg cctaccagaa acggatggga gtgcaaatgc agcgattcaa      780

gtgatcctct cgttattgca gcaagtatca ttgggatctt gcacttgata ttgtggattc      840

ttgatcgtct tttcttcaaa ttcatttatc gtcgccttaa atacgggttg aaaagagggc      900

cttctacgga aggagtacct gagtctatga gggaagaata tcggcaggaa cagcagaatg      960

ctgtggatgt tgacgatggt cattttgtca acatagagct ggagtaaaaa actaccttgt     1020

ttctact                                                               1027


<210>  18
<211>  252
<212>  PRT
<213>  Influenza A virus

<400>  18

Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Val Pro 
1               5                   10                  15      


Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe 
            20                  25                  30          


Ala Gly Lys Asn Thr Asp Leu Glu Ala Leu Met Glu Trp Leu Lys Thr 
        35                  40                  45              


Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe 
    50                  55                  60                  


Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val 
65                  70                  75                  80  


Gln Asn Ala Leu Ser Gly Asn Gly Asp Pro Asn Asn Met Asp Arg Ala 
                85                  90                  95      


Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala 
            100                 105                 110         


Lys Glu Val Ala Leu Ser Tyr Ser Thr Gly Ala Leu Ala Ser Cys Met 
        115                 120                 125             


Gly Leu Ile Tyr Asn Arg Met Gly Thr Val Thr Thr Glu Val Ala Phe 
    130                 135                 140                 


Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg 
145                 150                 155                 160 


Ser His Arg Gln Met Val Thr Thr Thr Asn Pro Leu Ile Arg His Glu 
                165                 170                 175     


Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met 
            180                 185                 190         


Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala Ser Arg 
        195                 200                 205             


Ala Arg Gln Met Val Gln Ala Met Arg Thr Ile Gly Thr His Pro Ser 
    210                 215                 220                 


Ser Ser Ala Gly Leu Lys Asp Asp Leu Ile Glu Asn Leu Gln Ala Tyr 
225                 230                 235                 240 


Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys 
                245                 250         


<210>  19
<211>  97
<212>  PRT
<213>  Influenza A virus

<400>  19

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Gly Trp Glu 
1               5                   10                  15      


Cys Lys Cys Ser Asp Ser Ser Asp Pro Leu Val Ile Ala Ala Ser Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Phe Ile Tyr Arg Arg Leu Lys Tyr Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Glu Ser Met Arg Glu Glu Tyr Arg Gln Glu Gln 
65                  70                  75                  80  


Gln Asn Ala Val Asp Val Asp Asp Gly His Phe Val Asn Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  20
<211>  890
<212>  DNA
<213>  Influenza A virus

<400>  20
agcaaaagca gggtgacaaa aacataatgg attccaacac tgtgtcaagc tttcaggtag       60

actgttttct ttggcatgtc cgcaaacgat tcgcagacca agaactgggt gatgccccat      120

tccttgaccg gcttcgccga gaccagaagt ccctaagggg aagaggtagc actcttggtc      180

tggacatcga aacagccact catgcaggaa agcagatagt ggagcagatt ctggaaaagg      240

aatcagatga ggcacttaaa atgaccattg cctctgttcc tacttcacgc tacttaactg      300

acatgactct tgatgagatg tcaagagact ggttcatgct catgcccaag caaaaagtaa      360

caggctccct atgtataaga atggaccagg caatcatgga taagaacatc atacttaaag      420

caaactttag tgtgattttc gaaaggctgg aaacactaat actacttaga gccttcaccg      480

aagaaggagc agtcgttggc gaaatttcac cattaccttc tcttccagga catactaatg      540

aggatgtcaa aaatgcaatt ggggtcctca tcggaggact taaatggaat gataatacgg      600

ttagaatctc tgaaactcta cagagattcg cttggagaag cagtcatgag aatgggagac      660

cttcattccc ttcaaagcag aaatgaaaaa tggagagaac aattaagcca gaaatttgaa      720

gaaataagat ggttgattga agaagtgcga catagattga aaaatacaga aaatagtttt      780

gaacaaataa catttatgca agccttacaa ctattgcttg aagtagaaca agagataaga      840

actttctcgt ttcagcttat ttaatgataa aaaacaccct tgtttctact                 890


<210>  21
<211>  219
<212>  PRT
<213>  Influenza A virus

<400>  21

Met Asp Ser Asn Thr Val Ser Ser Phe Gln Val Asp Cys Phe Leu Trp 
1               5                   10                  15      


His Val Arg Lys Arg Phe Ala Asp Gln Glu Leu Gly Asp Ala Pro Phe 
            20                  25                  30          


Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly Arg Gly Ser 
        35                  40                  45              


Thr Leu Gly Leu Asp Ile Glu Thr Ala Thr His Ala Gly Lys Gln Ile 
    50                  55                  60                  


Val Glu Gln Ile Leu Glu Lys Glu Ser Asp Glu Ala Leu Lys Met Thr 
65                  70                  75                  80  


Ile Ala Ser Val Pro Thr Ser Arg Tyr Leu Thr Asp Met Thr Leu Asp 
                85                  90                  95      


Glu Met Ser Arg Asp Trp Phe Met Leu Met Pro Lys Gln Lys Val Thr 
            100                 105                 110         


Gly Ser Leu Cys Ile Arg Met Asp Gln Ala Ile Met Asp Lys Asn Ile 
        115                 120                 125             


Ile Leu Lys Ala Asn Phe Ser Val Ile Phe Glu Arg Leu Glu Thr Leu 
    130                 135                 140                 


Ile Leu Leu Arg Ala Phe Thr Glu Glu Gly Ala Val Val Gly Glu Ile 
145                 150                 155                 160 


Ser Pro Leu Pro Ser Leu Pro Gly His Thr Asn Glu Asp Val Lys Asn 
                165                 170                 175     


Ala Ile Gly Val Leu Ile Gly Gly Leu Lys Trp Asn Asp Asn Thr Val 
            180                 185                 190         


Arg Ile Ser Glu Thr Leu Gln Arg Phe Ala Trp Arg Ser Ser His Glu 
        195                 200                 205             


Asn Gly Arg Pro Ser Phe Pro Ser Lys Gln Lys 
    210                 215                 


<210>  22
<211>  121
<212>  PRT
<213>  Influenza A virus

<400>  22

Met Asp Ser Asn Thr Val Ser Ser Phe Gln Asp Ile Leu Met Arg Met 
1               5                   10                  15      


Ser Lys Met Gln Leu Gly Ser Ser Ser Glu Asp Leu Asn Gly Met Ile 
            20                  25                  30          


Ile Arg Leu Glu Ser Leu Lys Leu Tyr Arg Asp Ser Leu Gly Glu Ala 
        35                  40                  45              


Val Met Arg Met Gly Asp Leu His Ser Leu Gln Ser Arg Asn Glu Lys 
    50                  55                  60                  


Trp Arg Glu Gln Leu Ser Gln Lys Phe Glu Glu Ile Arg Trp Leu Ile 
65                  70                  75                  80  


Glu Glu Val Arg His Arg Leu Lys Asn Thr Glu Asn Ser Phe Glu Gln 
                85                  90                  95      


Ile Thr Phe Met Gln Ala Leu Gln Leu Leu Leu Glu Val Glu Gln Glu 
            100                 105                 110         


Ile Arg Thr Phe Ser Phe Gln Leu Ile 
        115                 120     


<210>  23
<211>  1768
<212>  DNA
<213>  Influenza A virus

<400>  23
agcaaaagca ggggatattt ctgtcaatca tgaagacaac cattattttt atttttatac       60

tactgaccca ttgggcctac agtcaaaacc caatcagtaa caacaacaca gccacattgt      120

gtctgggaca ccatgcagta gcaaatggaa cattagtaaa aacaataagt gatgatcaaa      180

ttgaggtgac aaatgctaca gaattagttc agagcatttc aatggggaaa atatgcaaca      240

actcatatag aattctagat ggaagaaatt gcacattaat agatgcaatg ctaggagacc      300

cccactgtga cgtctttcag tatgagaatt gggacctctt tatagaaaga agcagcgctt      360

tcagcaattg ctacccatat gacatccctg actatgcatc gctccgatca attgtagcat      420

cctcaggaac attggaattc acagcagagg gattcacatg gacaggtgtc actcaaaacg      480

gaagaagtgg agcctgcaaa aggggatcag ccgatagttt ctttagccga ctgaattggc      540

taacaaaatc tggaaactct tatcccacat tgaatgtgac aatgcctaac aataaaaatt      600

tcgacaagct atacatctgg gggattcatc acccgagttc aaatcaagag cagacaaaat      660

tgtatatcca agaatcagga cgagtaacag tctcaacaaa aagaagtcaa caaacaataa      720

tccctaacat cggatctaga ccgtgggtca gaggtcaatc aggcaggata agcatatact      780

ggaccattgt aaaacctgga gatatcctaa tgataaacag taatggcaac ttagttgcac      840

cgcggggata ttttaaattg aaaacaggga aaagctctgt aatgagatca gatgtaccca      900

tagacatttg tgtgtctgaa tgtattacac caaatggaag catctccaac gaaaagccat      960

tccaaaatgt aaacaaagtt acatatggaa aatgccccaa atatatcagg caaaacactt     1020

taaagttggc cactggaatg agaaatgtac cagaaaagca aatcagagga atctttggag     1080

caatagcggg attcatcgaa aacggctggg aaggaatggt tgatgggtgg tatgggttcc     1140

gataccaaaa ctctgaagga acaggacaag ctgcagatct aaagagcact caaacagcca     1200

tcgaccagat taatgaaaag ttaaacagag tgattgaaag aaccaatgaa aaattccatc     1260

agatagagaa ggaattctca gaagtagaag gaagaattca ggacttggag aaatatgtgg     1320

aagacaccaa aatagaccta tggtcctaca atgcagaatt gctggtggct ctagaaaatc     1380

aacatacaat tgacttaaca gatgcagaaa tgaataaatt attcgagaag actagacgcc     1440

agttaagaga aaacgcagaa gacatgggag gtggatgttt caagatttac cacaaatgtg     1500

ataatgcatg cattggatca ataagaaatg ggacatatga ccattacata tacagagatg     1560

aagcattaaa caaccgattt caaatcaaag gtgttgagtt gaaatcaggc tacaaagatt     1620

ggatactgtg gatttcattc gccatatcat gcttcttaat ttgcgttgtt ctattgggtt     1680

ttattatgtg ggcttgccaa aaaggcaaca tcagatgcaa catttgcatt tgagtaaact     1740

gatagttaaa aacacccttg tttctact                                        1768


<210>  24
<211>  567
<212>  PRT
<213>  Influenza A virus

<400>  24

Met Lys Thr Thr Ile Ile Phe Ile Phe Ile Leu Leu Thr His Trp Ala 
1               5                   10                  15      


Tyr Ser Gln Asn Pro Ile Ser Asn Asn Asn Thr Ala Thr Leu Cys Leu 
            20                  25                  30          


Gly His His Ala Val Ala Asn Gly Thr Leu Val Lys Thr Ile Ser Asp 
        35                  40                  45              


Asp Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ile Ser 
    50                  55                  60                  


Met Gly Lys Ile Cys Asn Asn Ser Tyr Arg Ile Leu Asp Gly Arg Asn 
65                  70                  75                  80  


Cys Thr Leu Ile Asp Ala Met Leu Gly Asp Pro His Cys Asp Val Phe 
                85                  90                  95      


Gln Tyr Glu Asn Trp Asp Leu Phe Ile Glu Arg Ser Ser Ala Phe Ser 
            100                 105                 110         


Asn Cys Tyr Pro Tyr Asp Ile Pro Asp Tyr Ala Ser Leu Arg Ser Ile 
        115                 120                 125             


Val Ala Ser Ser Gly Thr Leu Glu Phe Thr Ala Glu Gly Phe Thr Trp 
    130                 135                 140                 


Thr Gly Val Thr Gln Asn Gly Arg Ser Gly Ala Cys Lys Arg Gly Ser 
145                 150                 155                 160 


Ala Asp Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Asn 
                165                 170                 175     


Ser Tyr Pro Thr Leu Asn Val Thr Met Pro Asn Asn Lys Asn Phe Asp 
            180                 185                 190         


Lys Leu Tyr Ile Trp Gly Ile His His Pro Ser Ser Asn Gln Glu Gln 
        195                 200                 205             


Thr Lys Leu Tyr Ile Gln Glu Ser Gly Arg Val Thr Val Ser Thr Lys 
    210                 215                 220                 


Arg Ser Gln Gln Thr Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp Val 
225                 230                 235                 240 


Arg Gly Gln Ser Gly Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro 
                245                 250                 255     


Gly Asp Ile Leu Met Ile Asn Ser Asn Gly Asn Leu Val Ala Pro Arg 
            260                 265                 270         


Gly Tyr Phe Lys Leu Lys Thr Gly Lys Ser Ser Val Met Arg Ser Asp 
        275                 280                 285             


Val Pro Ile Asp Ile Cys Val Ser Glu Cys Ile Thr Pro Asn Gly Ser 
    290                 295                 300                 


Ile Ser Asn Glu Lys Pro Phe Gln Asn Val Asn Lys Val Thr Tyr Gly 
305                 310                 315                 320 


Lys Cys Pro Lys Tyr Ile Arg Gln Asn Thr Leu Lys Leu Ala Thr Gly 
                325                 330                 335     


Met Arg Asn Val Pro Glu Lys Gln Ile Arg Gly Ile Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Phe Arg Tyr Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu 
    370                 375                 380                 


Lys Ser Thr Gln Thr Ala Ile Asp Gln Ile Asn Glu Lys Leu Asn Arg 
385                 390                 395                 400 


Val Ile Glu Arg Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe 
                405                 410                 415     


Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp 
            420                 425                 430         


Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu 
        435                 440                 445             


Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ala Glu Met Asn Lys Leu 
    450                 455                 460                 


Phe Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly 
465                 470                 475                 480 


Gly Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly 
                485                 490                 495     


Ser Ile Arg Asn Gly Thr Tyr Asp His Tyr Ile Tyr Arg Asp Glu Ala 
            500                 505                 510         


Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr 
        515                 520                 525             


Lys Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Ile 
    530                 535                 540                 


Cys Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn 
545                 550                 555                 560 


Ile Arg Cys Asn Ile Cys Ile 
                565         


<210>  25
<211>  1460
<212>  DNA
<213>  Influenza A virus

<400>  25
agcaaaagca ggagtttaaa atgaatccaa atcaaaagat aataacaatt ggatctgcat       60

cattggggat attaatcatt aacgtcattc tccatgtagt cagcattata gtaacagtac      120

tggtcctcaa taacaatgaa acaggtctga actgcaaagg gacgatcata agagagtaca      180

atgaaacagt aagagtagaa aaaattactc aatggcataa taccagtgca attaagtaca      240

tagagagacc tccaaatgaa tactacatga acaacaccga accactttgt gaggcccaag      300

gctttgcacc attttccaaa gataatggaa tacgaattgg gtcgagaggc catgtttttg      360

tgataagaga accttttgta tcatgttcgc cctcagaatg tagaaccttt ttcctcacac      420

agggctcatt actcaatgac aaacattcta acggcacagt aaaggatcga agtccatata      480

ggactttgat gagtgtcaaa atagggcaat cacctaatgt gtatcaagct aggtttgaat      540

cggtggcatg gtcagcaaca gcatgccatg atggaaaaaa atggatgaca attggagtca      600

cagggcccga caatcaagca attgcagtag tgaactatgg gggtgttccg gttgatatta      660

ttaattcatg ggcaggggac atcttaagaa cccaagaatc atcatgcacc tgcattaaag      720

gaaactgtta ttgggtaatg actgatggac cggcaaatag gcaagctaaa tatagaatat      780

tcaaagcaaa agatggaaga gtaattggac agactgatat aagcttcaat gggggacaca      840

tagaggagtg ttcttgttac cccaatgaag ggaaggtgga atgcatatgc agggacaatt      900

ggactggaac aaatagacca attctggtaa tatcttctga tctatcgtac acagttggat      960

atttgtgtgc tggcattccc actgacactc ctaggggaga ggatagtcaa ttcacaggct     1020

catgtacaag tcctttggga aataaaggat acggtgtaaa aggtttcggg tttcgacaag     1080

gaactgacgt atgggccgga aggacaatta gtaggacttc gagatcagga ttcgaaataa     1140

taaaaatcag gaatggttgg acacagaaca gtaaagacca aatcaggagg caagtgatta     1200

tcgatgaccc aaattggtca ggatatagcg gttctttcac attgccgatt gaactaacaa     1260

aaaagggatg tttggtcccc tgtttctggg ttgaaatgat tagaggtaaa cctgaagaaa     1320

caacaatatg gacctctagc agctccattg tgatgtgtgg agtagatcat aaaattgcca     1380

gttggtcatg gcacgatgga gctattcttc cctttgacat cgataagatg taatttacga     1440

aaaaactcct tgtttctact                                                 1460


<210>  26
<211>  470
<212>  PRT
<213>  Influenza A virus

<400>  26

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ala Ser Leu Gly 
1               5                   10                  15      


Ile Leu Ile Ile Asn Val Ile Leu His Val Val Ser Ile Ile Val Thr 
            20                  25                  30          


Val Leu Val Leu Asn Asn Asn Glu Thr Gly Leu Asn Cys Lys Gly Thr 
        35                  40                  45              


Ile Ile Arg Glu Tyr Asn Glu Thr Val Arg Val Glu Lys Ile Thr Gln 
    50                  55                  60                  


Trp His Asn Thr Ser Ala Ile Lys Tyr Ile Glu Arg Pro Pro Asn Glu 
65                  70                  75                  80  


Tyr Tyr Met Asn Asn Thr Glu Pro Leu Cys Glu Ala Gln Gly Phe Ala 
                85                  90                  95      


Pro Phe Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Arg Gly His Val 
            100                 105                 110         


Phe Val Ile Arg Glu Pro Phe Val Ser Cys Ser Pro Ser Glu Cys Arg 
        115                 120                 125             


Thr Phe Phe Leu Thr Gln Gly Ser Leu Leu Asn Asp Lys His Ser Asn 
    130                 135                 140                 


Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Val Lys 
145                 150                 155                 160 


Ile Gly Gln Ser Pro Asn Val Tyr Gln Ala Arg Phe Glu Ser Val Ala 
                165                 170                 175     


Trp Ser Ala Thr Ala Cys His Asp Gly Lys Lys Trp Met Thr Ile Gly 
            180                 185                 190         


Val Thr Gly Pro Asp Asn Gln Ala Ile Ala Val Val Asn Tyr Gly Gly 
        195                 200                 205             


Val Pro Val Asp Ile Ile Asn Ser Trp Ala Gly Asp Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ser Cys Thr Cys Ile Lys Gly Asn Cys Tyr Trp Val Met 
225                 230                 235                 240 


Thr Asp Gly Pro Ala Asn Arg Gln Ala Lys Tyr Arg Ile Phe Lys Ala 
                245                 250                 255     


Lys Asp Gly Arg Val Ile Gly Gln Thr Asp Ile Ser Phe Asn Gly Gly 
            260                 265                 270         


His Ile Glu Glu Cys Ser Cys Tyr Pro Asn Glu Gly Lys Val Glu Cys 
        275                 280                 285             


Ile Cys Arg Asp Asn Trp Thr Gly Thr Asn Arg Pro Ile Leu Val Ile 
    290                 295                 300                 


Ser Ser Asp Leu Ser Tyr Thr Val Gly Tyr Leu Cys Ala Gly Ile Pro 
305                 310                 315                 320 


Thr Asp Thr Pro Arg Gly Glu Asp Ser Gln Phe Thr Gly Ser Cys Thr 
                325                 330                 335     


Ser Pro Leu Gly Asn Lys Gly Tyr Gly Val Lys Gly Phe Gly Phe Arg 
            340                 345                 350         


Gln Gly Thr Asp Val Trp Ala Gly Arg Thr Ile Ser Arg Thr Ser Arg 
        355                 360                 365             


Ser Gly Phe Glu Ile Ile Lys Ile Arg Asn Gly Trp Thr Gln Asn Ser 
    370                 375                 380                 


Lys Asp Gln Ile Arg Arg Gln Val Ile Ile Asp Asp Pro Asn Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Thr Leu Pro Ile Glu Leu Thr Lys Lys Gly 
                405                 410                 415     


Cys Leu Val Pro Cys Phe Trp Val Glu Met Ile Arg Gly Lys Pro Glu 
            420                 425                 430         


Glu Thr Thr Ile Trp Thr Ser Ser Ser Ser Ile Val Met Cys Gly Val 
        435                 440                 445             


Asp His Lys Ile Ala Ser Trp Ser Trp His Asp Gly Ala Ile Leu Pro 
    450                 455                 460                 


Phe Asp Ile Asp Lys Met 
465                 470 


<210>  27
<211>  1762
<212>  DNA
<213>  Influenza A virus

<400>  27
agcgaaagca ggggatattt ctgtcaatca tgacgataac cattattttg atactactga       60

cccattgggc ttacagtcaa aacccaatca atgacaacaa cacagccaca ttgtgtctag      120

gacaccatgc agtagcaaat ggaacattgg taaaaacaat aagtgatgat caaattgagg      180

tgacaaatgc tacagaatta gttcagagca ttccaatggg gaaaatatgc aacaattcgt      240

atagaattct agatggaaag gattgcacat taatagatgc aatgctagga gacccccact      300

gtgacgcctt tcagtatgag aattgggacc tctttataga aagaagcagc gccttcagca      360

attgctaccc atatgacatc cctaactatg catcgctccg atccattgta gcatcctcag      420

gaacattgga attcacagca gagggattca catggacagg tgtcactcaa aacggaagaa      480

gcggatcctg caaaagggga tcagccgata gtttctttag ccgactgaat tggctaacaa      540

aatccggaag ctcttacccc acattgaatg tgacaatgcc taacaataaa aacttcgaca      600

agctatacat ctgggggatc catcacccga gctcaactca agagcagaca aaattgtata      660

tccaggaatc agggcgagta acagtctcaa caaaaagaag tcaacaaaca ataatcccta      720

acattgggtc tagaccatgg atcagaggtc aatcaggtag gataagcata tactggacca      780

ttgtaaaacc tggagatatt ctaatgataa acagtaatgg caacttagtt gcaccgcggg      840

gatactttaa attgaaaaca gggaaaagct ctgtaatgag atcagatgta cccatagaca      900

tttgtgtgtc tgaatgtatt acaccaaatg gaagcatctc caacgacaag ccattccaaa      960

atgtgaacaa agttacatat ggaaaatgtc ccaagtatat cagacaaaac actttaaagc     1020

tggccactgg gatgaggaat gtaccagaaa agcaaatcag aggaatcttc ggggcaatag     1080

cgggattcat cgaaaacggc tgggaaggaa tggttgatgg atggtatggg ttccgatacc     1140

aaaactctga aggaacaggg caagctgcag atctaaagag cactcaagca gccatcgacc     1200

agatcaatgg aaagttaaac agagtgattg aaagaacaaa tgagaaattc catcaaatag     1260

agaaggaatt ctcagaagta gaaggaagaa ttcaggactt ggagaaatat gtagaagaca     1320

ccaaaataga cctatggtcc tacaatgcag aattgctggt ggctctagaa aatcaacata     1380

caattgactt aacagatgca gaaatgaata aattgtttga gagaactaga cgcctgttaa     1440

gagaaaacgc agaagacatg ggaggtggat gtttcaagat ttaccacaaa tgtaataatg     1500

catgcattgg atcaataaga aatgggacat atgaccatta catatacaga gatgaagcat     1560

taaacaaccg atttcagatc aaaggtgtag agttgaaatc aggctacaaa gattggatac     1620

tctggatttc attcgccata tcatgcttct taatttgcgt tgttctattg ggttttatta     1680

tgtgggcttg ccaaaaaggc aacatcagat gcaacatttg catttgagta gattaatagt     1740

taaaaacacc cttgtttcta ct                                              1762


<210>  28
<211>  565
<212>  PRT
<213>  Influenza A virus

<400>  28

Met Thr Ile Thr Ile Ile Leu Ile Leu Leu Thr His Trp Ala Tyr Ser 
1               5                   10                  15      


Gln Asn Pro Ile Asn Asp Asn Asn Thr Ala Thr Leu Cys Leu Gly His 
            20                  25                  30          


His Ala Val Ala Asn Gly Thr Leu Val Lys Thr Ile Ser Asp Asp Gln 
        35                  40                  45              


Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ile Pro Met Gly 
    50                  55                  60                  


Lys Ile Cys Asn Asn Ser Tyr Arg Ile Leu Asp Gly Lys Asp Cys Thr 
65                  70                  75                  80  


Leu Ile Asp Ala Met Leu Gly Asp Pro His Cys Asp Ala Phe Gln Tyr 
                85                  90                  95      


Glu Asn Trp Asp Leu Phe Ile Glu Arg Ser Ser Ala Phe Ser Asn Cys 
            100                 105                 110         


Tyr Pro Tyr Asp Ile Pro Asn Tyr Ala Ser Leu Arg Ser Ile Val Ala 
        115                 120                 125             


Ser Ser Gly Thr Leu Glu Phe Thr Ala Glu Gly Phe Thr Trp Thr Gly 
    130                 135                 140                 


Val Thr Gln Asn Gly Arg Ser Gly Ser Cys Lys Arg Gly Ser Ala Asp 
145                 150                 155                 160 


Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Ser Ser Tyr 
                165                 170                 175     


Pro Thr Leu Asn Val Thr Met Pro Asn Asn Lys Asn Phe Asp Lys Leu 
            180                 185                 190         


Tyr Ile Trp Gly Ile His His Pro Ser Ser Thr Gln Glu Gln Thr Lys 
        195                 200                 205             


Leu Tyr Ile Gln Glu Ser Gly Arg Val Thr Val Ser Thr Lys Arg Ser 
    210                 215                 220                 


Gln Gln Thr Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp Ile Arg Gly 
225                 230                 235                 240 


Gln Ser Gly Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly Asp 
                245                 250                 255     


Ile Leu Met Ile Asn Ser Asn Gly Asn Leu Val Ala Pro Arg Gly Tyr 
            260                 265                 270         


Phe Lys Leu Lys Thr Gly Lys Ser Ser Val Met Arg Ser Asp Val Pro 
        275                 280                 285             


Ile Asp Ile Cys Val Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile Ser 
    290                 295                 300                 


Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Val Thr Tyr Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Ile Arg Gln Asn Thr Leu Lys Leu Ala Thr Gly Met Arg 
                325                 330                 335     


Asn Val Pro Glu Lys Gln Ile Arg Gly Ile Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe 
        355                 360                 365             


Arg Tyr Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Val Ile 
385                 390                 395                 400 


Glu Arg Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser Glu 
                405                 410                 415     


Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys 
            420                 425                 430         


Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn 
        435                 440                 445             


Gln His Thr Ile Asp Leu Thr Asp Ala Glu Met Asn Lys Leu Phe Glu 
    450                 455                 460                 


Arg Thr Arg Arg Leu Leu Arg Glu Asn Ala Glu Asp Met Gly Gly Gly 
465                 470                 475                 480 


Cys Phe Lys Ile Tyr His Lys Cys Asn Asn Ala Cys Ile Gly Ser Ile 
                485                 490                 495     


Arg Asn Gly Thr Tyr Asp His Tyr Ile Tyr Arg Asp Glu Ala Leu Asn 
            500                 505                 510         


Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys Asp 
        515                 520                 525             


Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Ile Cys Val 
    530                 535                 540                 


Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile Arg 
545                 550                 555                 560 


Cys Asn Ile Cys Ile 
                565 


<210>  29
<211>  1460
<212>  DNA
<213>  Influenza A virus

<400>  29
agcaaaagca ggagtttaaa atgaatccaa atcaaaagat aatagcaatt ggatttacat       60

cattggggat attaatcatt agtgtcattc tccatgtagt cagcattata gtaacagtac      120

tggccctaaa taacaacaga acagatctga actgcaaaga gacgatcata agggagtaca      180

atgaaacagt aagagtagaa aaaattactc aatggtataa tatcagtaca attaagtaca      240

tagagaaacc ttcaaatgaa tactatatga acaacactga accactttgt gaggcccaag      300

gctttgcacc attttccaaa gataatggaa tacgaattgg atcgaggggc catgtttttg      360

tgataagaga accttttgta tcatgttcgc cttcagaatg tagaaccttt ttcctcacac      420

agggctcatt actcaatgac aaacattcta acggcacaat aaaggaccga agtccgtata      480

gaactctgat gagtgtcaaa atagggcaat cacctaatgt atatcaagct aggtttgaat      540

cagtggcatg gtcagcaaca gcatgccatg atggaaaaaa atggatgacg gttggagtca      600

cagggcctga caaccaagca attgcagtag tgaactatgg gggtgttccg gttgatatta      660

ttaattcatg ggcaggggat attttaagaa cccaagaatc gtcatgcacc tgcatcaaag      720

gagattgtta ttgggtaatg actgatgggc cggcgaatag gcaagccaaa tataagatat      780

tcaaagcaaa aaatggaaaa gtaattggac aaactgatat aagtttcaat ggaggacaca      840

tagaggagtg ttcttgttac cccaatgaag ggaaggtgga atgcatatgc agggacaatt      900

ggactggaac aaatagacca attttggtaa tatcttctga tctatcatac acagttggat      960

atttgtgtgc tggcattccc actgacactc ctaggggaga ggatagtcaa ttcacgggct     1020

catgtacaaa ccctttggga aataaaggat acggtgtaaa aggtttcgga tttcgacaag     1080

gaactgacgt atgggccgga aggacaatta gtagaacttc aagatcagga ttcgaaataa     1140

taaaaatcag gaatggttgg acacagaaca gtaaagacca aataaggagg caagtgatta     1200

tcgatgatca aaattggtca ggatatagcg gttctttcac attgccggtt gaactaacaa     1260

aaaaagaatg tttggtgccc tgtttctggg ttgaaatgat tagaggtaaa cctgaagaaa     1320

aaacaatatg gacctctagc agctccattg tgatgtgtgg agtagatcat aaaattgcca     1380

gttggtcatg gcacgatgga gctattcttc cctttgacat cgataagatg taatttacga     1440

aaaaactcct tgtttctact                                                 1460


<210>  30
<211>  470
<212>  PRT
<213>  Influenza A virus

<400>  30

Met Asn Pro Asn Gln Lys Ile Ile Ala Ile Gly Phe Thr Ser Leu Gly 
1               5                   10                  15      


Ile Leu Ile Ile Ser Val Ile Leu His Val Val Ser Ile Ile Val Thr 
            20                  25                  30          


Val Leu Ala Leu Asn Asn Asn Arg Thr Asp Leu Asn Cys Lys Glu Thr 
        35                  40                  45              


Ile Ile Arg Glu Tyr Asn Glu Thr Val Arg Val Glu Lys Ile Thr Gln 
    50                  55                  60                  


Trp Tyr Asn Ile Ser Thr Ile Lys Tyr Ile Glu Lys Pro Ser Asn Glu 
65                  70                  75                  80  


Tyr Tyr Met Asn Asn Thr Glu Pro Leu Cys Glu Ala Gln Gly Phe Ala 
                85                  90                  95      


Pro Phe Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Arg Gly His Val 
            100                 105                 110         


Phe Val Ile Arg Glu Pro Phe Val Ser Cys Ser Pro Ser Glu Cys Arg 
        115                 120                 125             


Thr Phe Phe Leu Thr Gln Gly Ser Leu Leu Asn Asp Lys His Ser Asn 
    130                 135                 140                 


Gly Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Val Lys 
145                 150                 155                 160 


Ile Gly Gln Ser Pro Asn Val Tyr Gln Ala Arg Phe Glu Ser Val Ala 
                165                 170                 175     


Trp Ser Ala Thr Ala Cys His Asp Gly Lys Lys Trp Met Thr Val Gly 
            180                 185                 190         


Val Thr Gly Pro Asp Asn Gln Ala Ile Ala Val Val Asn Tyr Gly Gly 
        195                 200                 205             


Val Pro Val Asp Ile Ile Asn Ser Trp Ala Gly Asp Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ser Cys Thr Cys Ile Lys Gly Asp Cys Tyr Trp Val Met 
225                 230                 235                 240 


Thr Asp Gly Pro Ala Asn Arg Gln Ala Lys Tyr Lys Ile Phe Lys Ala 
                245                 250                 255     


Lys Asn Gly Lys Val Ile Gly Gln Thr Asp Ile Ser Phe Asn Gly Gly 
            260                 265                 270         


His Ile Glu Glu Cys Ser Cys Tyr Pro Asn Glu Gly Lys Val Glu Cys 
        275                 280                 285             


Ile Cys Arg Asp Asn Trp Thr Gly Thr Asn Arg Pro Ile Leu Val Ile 
    290                 295                 300                 


Ser Ser Asp Leu Ser Tyr Thr Val Gly Tyr Leu Cys Ala Gly Ile Pro 
305                 310                 315                 320 


Thr Asp Thr Pro Arg Gly Glu Asp Ser Gln Phe Thr Gly Ser Cys Thr 
                325                 330                 335     


Asn Pro Leu Gly Asn Lys Gly Tyr Gly Val Lys Gly Phe Gly Phe Arg 
            340                 345                 350         


Gln Gly Thr Asp Val Trp Ala Gly Arg Thr Ile Ser Arg Thr Ser Arg 
        355                 360                 365             


Ser Gly Phe Glu Ile Ile Lys Ile Arg Asn Gly Trp Thr Gln Asn Ser 
    370                 375                 380                 


Lys Asp Gln Ile Arg Arg Gln Val Ile Ile Asp Asp Gln Asn Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Thr Leu Pro Val Glu Leu Thr Lys Lys Glu 
                405                 410                 415     


Cys Leu Val Pro Cys Phe Trp Val Glu Met Ile Arg Gly Lys Pro Glu 
            420                 425                 430         


Glu Lys Thr Ile Trp Thr Ser Ser Ser Ser Ile Val Met Cys Gly Val 
        435                 440                 445             


Asp His Lys Ile Ala Ser Trp Ser Trp His Asp Gly Ala Ile Leu Pro 
    450                 455                 460                 


Phe Asp Ile Asp Lys Met 
465                 470 


<210>  31
<211>  1768
<212>  DNA
<213>  Influenza A virus

<400>  31
agcgaaagca ggggatattt ctgtcaatca tgaagacaac cattattttt aattttatac       60

tactgaccca ttgggcctac agtcaaaacc caatcagtaa caacaacaca gccacattgt      120

gtctgggaca ccatgcagta gcaaatggaa cattagtaaa aacaataagt gatgatcaaa      180

ttgaggtgac aaatgctaca gaattagttc agagcatttc aatggggaaa atatgcaaca      240

actcatatag aattctagat ggaagaaatt gcacgttaat agatgcaatg ttaggagacc      300

cccactgtga tgtctttcag tatgagaatt gggacctctt tatagaaaga agcagcgctt      360

tcagcaattg ctacccatat gacatcctcg actatgcatc gcttcgatca attatagcat      420

cctcaggaac attggaattc acagcagagg gattcacatg gacaggtgtc actcagaacg      480

gaagaagtgg agcctgcaaa aggggatcgg tcgatagttt ctttagccga ctgaattggc      540

taacgaaatc tggaaactct tatcccacat tgaatgtgac aatgcctaac aataaaaatt      600

tcgacaagct atacatctgg gggattcatc acccgagttc aaatcaagag cagaaaaaat      660

tgtatatcca agaatcagga cgagtaacag tctcaacaaa aagaagtcaa cagacaataa      720

ttcctaatat cggatctaga ccgtgggtca gaggtcaatc aggcagaata agcatatact      780

ggaccattgt aaaacctgga gatatcctaa tgataaacag taatggcaac ttagttgcgc      840

cgcggggata ttttaaattg aaaacaggga aaagctctat aatgagatca gacgtaccca      900

tagacatttg tgtgtctgaa tgtattacac caaatggaag catctccaac gacaagccat      960

tccaaaatgt aaacaaaatt acatatggaa aatgccccaa atatatcagg caaaacactt     1020

taaagttggc cactggaatg agaaatgtac cagaaaagca aatcagagga atctttggag     1080

caatagcggg attcatcgaa aacggctggg aaggaatggt tgatgggtgg tatgggttcc     1140

gataccaaaa ctctgaagga acaggacaag ctgcagatct aaagagcact caagcagcca     1200

tcgaccagat taatgaaaag ttaaatagag tgattgaaag aaccaatgag aaattccatc     1260

agatagagaa ggaattctca gaagtagaag gaagaattca ggacttggag aaatatgtgg     1320

aagacaccaa aatagaccta tggtcctaca atgcagaatt gctggtggct ctagaaaatc     1380

aacatacaat tgacttaaca gatgcagaaa tgaataaatt gttcgagaag actagacgcc     1440

agttaagaga aaacgcagaa gacatggggg gtggatgttt caagatttac cacaaatgtg     1500

ataatgcatg cattggatca ataagaaatg gaacatatga ccattacata tacagagatg     1560

aagcattaaa caaccgattt cagatcaaag gtgttgagtt gaaatcaggc tataaagatt     1620

ggataatatg gatttcattt gccatatcat gcttcttaat ttgcgttgtt ctattgggtt     1680

ttattatgtg ggcttgccaa aaaggcaaca tcagatgcaa catttgcatt tgagtaaact     1740

gatagttaaa aacacccttg tttctact                                        1768


<210>  32
<211>  567
<212>  PRT
<213>  Influenza A virus

<400>  32

Met Lys Thr Thr Ile Ile Phe Asn Phe Ile Leu Leu Thr His Trp Ala 
1               5                   10                  15      


Tyr Ser Gln Asn Pro Ile Ser Asn Asn Asn Thr Ala Thr Leu Cys Leu 
            20                  25                  30          


Gly His His Ala Val Ala Asn Gly Thr Leu Val Lys Thr Ile Ser Asp 
        35                  40                  45              


Asp Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ile Ser 
    50                  55                  60                  


Met Gly Lys Ile Cys Asn Asn Ser Tyr Arg Ile Leu Asp Gly Arg Asn 
65                  70                  75                  80  


Cys Thr Leu Ile Asp Ala Met Leu Gly Asp Pro His Cys Asp Val Phe 
                85                  90                  95      


Gln Tyr Glu Asn Trp Asp Leu Phe Ile Glu Arg Ser Ser Ala Phe Ser 
            100                 105                 110         


Asn Cys Tyr Pro Tyr Asp Ile Leu Asp Tyr Ala Ser Leu Arg Ser Ile 
        115                 120                 125             


Ile Ala Ser Ser Gly Thr Leu Glu Phe Thr Ala Glu Gly Phe Thr Trp 
    130                 135                 140                 


Thr Gly Val Thr Gln Asn Gly Arg Ser Gly Ala Cys Lys Arg Gly Ser 
145                 150                 155                 160 


Val Asp Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Asn 
                165                 170                 175     


Ser Tyr Pro Thr Leu Asn Val Thr Met Pro Asn Asn Lys Asn Phe Asp 
            180                 185                 190         


Lys Leu Tyr Ile Trp Gly Ile His His Pro Ser Ser Asn Gln Glu Gln 
        195                 200                 205             


Lys Lys Leu Tyr Ile Gln Glu Ser Gly Arg Val Thr Val Ser Thr Lys 
    210                 215                 220                 


Arg Ser Gln Gln Thr Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp Val 
225                 230                 235                 240 


Arg Gly Gln Ser Gly Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro 
                245                 250                 255     


Gly Asp Ile Leu Met Ile Asn Ser Asn Gly Asn Leu Val Ala Pro Arg 
            260                 265                 270         


Gly Tyr Phe Lys Leu Lys Thr Gly Lys Ser Ser Ile Met Arg Ser Asp 
        275                 280                 285             


Val Pro Ile Asp Ile Cys Val Ser Glu Cys Ile Thr Pro Asn Gly Ser 
    290                 295                 300                 


Ile Ser Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly 
305                 310                 315                 320 


Lys Cys Pro Lys Tyr Ile Arg Gln Asn Thr Leu Lys Leu Ala Thr Gly 
                325                 330                 335     


Met Arg Asn Val Pro Glu Lys Gln Ile Arg Gly Ile Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Phe Arg Tyr Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu 
    370                 375                 380                 


Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Glu Lys Leu Asn Arg 
385                 390                 395                 400 


Val Ile Glu Arg Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe 
                405                 410                 415     


Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp 
            420                 425                 430         


Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu 
        435                 440                 445             


Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ala Glu Met Asn Lys Leu 
    450                 455                 460                 


Phe Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly 
465                 470                 475                 480 


Gly Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly 
                485                 490                 495     


Ser Ile Arg Asn Gly Thr Tyr Asp His Tyr Ile Tyr Arg Asp Glu Ala 
            500                 505                 510         


Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr 
        515                 520                 525             


Lys Asp Trp Ile Ile Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Ile 
    530                 535                 540                 


Cys Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn 
545                 550                 555                 560 


Ile Arg Cys Asn Ile Cys Ile 
                565         


<210>  33
<211>  1460
<212>  DNA
<213>  Influenza A virus

<400>  33
agcaaaagca ggagtttaaa atgaatccga atcaaaagat aataacaatt ggatctgcat       60

cattggggat attaatcatt aacgtcattc tcaatgtagt cagcattata ataacagtac      120

tggtcctcaa taacaatgaa acatgtctga actgcaaagg gacgatcata agagagtaca      180

atgaaacagt aagagtagaa aaaattactc aatggcataa tacaagtgca attaagtaca      240

tagagagacc tccaaatgaa tactacatga acaacaccga accactttgt gaggcccaag      300

gctttgcacc attttccaaa gataatggaa tacgaattgg gtcgaaaggc catgtttttg      360

tgataagaga accctttgta tcatgttcgc cctcagaatg tagaaccttt ttcctcacac      420

agggctcatt actcaatgac aaacattcta acggcacagt aaaggatcga agtccataca      480

ggactttgat gagtgtcaaa atagggcaat cacccaatgt gtatcaagct aggtttgaat      540

cggtggcatg gtcagcaaca gcatgccatg atggaaaaaa atggatgaca attggagtca      600

cagggcccga caatcaagca attgcagtag tgaactatgg gggtgttccg gttgatatta      660

tcaattcatg ggcaggggac atcttaagaa cccaagaatc atcatgcacc tgcattaaag      720

gaaactgtta ttgggtaatg actgatggac cggcaaatag gcaagctaaa tataggatat      780

tcaaagcaaa agatgggaga gtaattggac agattgatat aaatttcaat gggggacaca      840

tagaggagtg ttcttgttac cccaatgaag ggaaagtgga atgcatatgc agggacaatt      900

ggactggaac aaatagaccg attctggtaa tatcttctga tctatcgtac acagttggat      960

atttgtgtgc tggcattccc actgacactc ctaggggaga ggatagtcaa ttcacaggct     1020

catgtacaag tcctttggga aataaaggat acggtgtaaa aggtttcggg tttcgacaag     1080

gaactgacgt atgggtcgga aggacaatta gtaggacttc gagatcagga ttcgaaataa     1140

taaaaatcag gaatggttgg acacagaata gtaaagacca aatcaggagg caagtgatca     1200

tcgatgaccc aaattggtca ggatatagcg gttctttcac attgccggtt gaattaacaa     1260

aaagaggatg tttggtcccc tgtttctggg ttgaaatgat tagaggtaaa cctgaagaat     1320

caacaatatg gacctctagc agctccattg tgatgtgtgg agtagatcat aaaattgcca     1380

gttggtcatg gcacgatgga gctattcttc cctttgacat cgataagatg taatttatga     1440

aaaaactcct tgtttctact                                                 1460


<210>  34
<211>  470
<212>  PRT
<213>  Influenza A virus

<400>  34

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ala Ser Leu Gly 
1               5                   10                  15      


Ile Leu Ile Ile Asn Val Ile Leu Asn Val Val Ser Ile Ile Ile Thr 
            20                  25                  30          


Val Leu Val Leu Asn Asn Asn Glu Thr Cys Leu Asn Cys Lys Gly Thr 
        35                  40                  45              


Ile Ile Arg Glu Tyr Asn Glu Thr Val Arg Val Glu Lys Ile Thr Gln 
    50                  55                  60                  


Trp His Asn Thr Ser Ala Ile Lys Tyr Ile Glu Arg Pro Pro Asn Glu 
65                  70                  75                  80  


Tyr Tyr Met Asn Asn Thr Glu Pro Leu Cys Glu Ala Gln Gly Phe Ala 
                85                  90                  95      


Pro Phe Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Lys Gly His Val 
            100                 105                 110         


Phe Val Ile Arg Glu Pro Phe Val Ser Cys Ser Pro Ser Glu Cys Arg 
        115                 120                 125             


Thr Phe Phe Leu Thr Gln Gly Ser Leu Leu Asn Asp Lys His Ser Asn 
    130                 135                 140                 


Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Val Lys 
145                 150                 155                 160 


Ile Gly Gln Ser Pro Asn Val Tyr Gln Ala Arg Phe Glu Ser Val Ala 
                165                 170                 175     


Trp Ser Ala Thr Ala Cys His Asp Gly Lys Lys Trp Met Thr Ile Gly 
            180                 185                 190         


Val Thr Gly Pro Asp Asn Gln Ala Ile Ala Val Val Asn Tyr Gly Gly 
        195                 200                 205             


Val Pro Val Asp Ile Ile Asn Ser Trp Ala Gly Asp Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ser Cys Thr Cys Ile Lys Gly Asn Cys Tyr Trp Val Met 
225                 230                 235                 240 


Thr Asp Gly Pro Ala Asn Arg Gln Ala Lys Tyr Arg Ile Phe Lys Ala 
                245                 250                 255     


Lys Asp Gly Arg Val Ile Gly Gln Ile Asp Ile Asn Phe Asn Gly Gly 
            260                 265                 270         


His Ile Glu Glu Cys Ser Cys Tyr Pro Asn Glu Gly Lys Val Glu Cys 
        275                 280                 285             


Ile Cys Arg Asp Asn Trp Thr Gly Thr Asn Arg Pro Ile Leu Val Ile 
    290                 295                 300                 


Ser Ser Asp Leu Ser Tyr Thr Val Gly Tyr Leu Cys Ala Gly Ile Pro 
305                 310                 315                 320 


Thr Asp Thr Pro Arg Gly Glu Asp Ser Gln Phe Thr Gly Ser Cys Thr 
                325                 330                 335     


Ser Pro Leu Gly Asn Lys Gly Tyr Gly Val Lys Gly Phe Gly Phe Arg 
            340                 345                 350         


Gln Gly Thr Asp Val Trp Val Gly Arg Thr Ile Ser Arg Thr Ser Arg 
        355                 360                 365             


Ser Gly Phe Glu Ile Ile Lys Ile Arg Asn Gly Trp Thr Gln Asn Ser 
    370                 375                 380                 


Lys Asp Gln Ile Arg Arg Gln Val Ile Ile Asp Asp Pro Asn Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Thr Leu Pro Val Glu Leu Thr Lys Arg Gly 
                405                 410                 415     


Cys Leu Val Pro Cys Phe Trp Val Glu Met Ile Arg Gly Lys Pro Glu 
            420                 425                 430         


Glu Ser Thr Ile Trp Thr Ser Ser Ser Ser Ile Val Met Cys Gly Val 
        435                 440                 445             


Asp His Lys Ile Ala Ser Trp Ser Trp His Asp Gly Ala Ile Leu Pro 
    450                 455                 460                 


Phe Asp Ile Asp Lys Met 
465                 470 


