                         SEQUENCE LISTING

<110>  Editas Medicine, Inc.
 
<120>  CRISPR/RNA-Guided Nuclease-Related Methods and Compositions for 
       Treating RHO-Associated Autosomal-Dominant Retinitis Pigmentosa 
       (ADRP)

<130>  118945-8018.WO00 (EM127PCT)

<140>  PCT/US2020/019766
<141>  2020-02-25

<150>  US 62/810,320
<151>  2019-02-25

<160>  1002  

<170>  PatentIn version 3.5

<210>  1
<211>  6706
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO genomic

<400>  1
agagtcatcc agctggagcc ctgagtggct gagctcaggc cttcgcagca ttcttgggtg       60

ggagcagcca cgggtcagcc acaagggcca cagccatgaa tggcacagaa ggccctaact      120

tctacgtgcc cttctccaat gcgacgggtg tggtacgcag ccccttcgag tacccacagt      180

actacctggc tgagccatgg cagttctcca tgctggccgc ctacatgttt ctgctgatcg      240

tgctgggctt ccccatcaac ttcctcacgc tctacgtcac cgtccagcac aagaagctgc      300

gcacgcctct caactacatc ctgctcaacc tagccgtggc tgacctcttc atggtcctag      360

gtggcttcac cagcaccctc tacacctctc tgcatggata cttcgtcttc gggcccacag      420

gatgcaattt ggagggcttc tttgccaccc tgggcggtat gagccgggtg tgggtggggt      480

gtgcaggagc ccgggagcat ggaggggtct gggagagtcc cgggcttggc ggtggtggct      540

gagaggcctt ctcccttctc ctgtcctgtc aatgttatcc aaagccctca tatattcagt      600

caacaaacac cattcatggt gatagccggg ctgctgtttg tgcagggctg gcactgaaca      660

ctgccttgat cttatttgga gcaatatgcg cttgtctaat ttcacagcaa gaaaactgag      720

ctgaggctca aagaagtcaa gcgccctgct ggggcgtcac acagggacgg gtgcagagtt      780

gagttggaag cccgcatcta tctcgggcca tgtttgcagc accaagcctc tgtttccctt      840

ggagcagctg tgctgagtca gacccaggct gggcactgag ggagagctgg gcaagccaga      900

cccctcctct ctgggggccc aagctcaggg tgggaagtgg attttccatt ctccagtcat      960

tgggtcttcc ctgtgctggg caatgggctc ggtcccctct ggcatcctct gcctcccctc     1020

tcagcccctg tcctcaggtg cccctccagc ctccctgccg cgttccaagt ctcctggtgt     1080

tgagaaccgc aagcagccgc tctgaagcag ttcctttttg ctttagaata atgtcttgca     1140

tttaacagga aaacagatgg ggtgctgcag ggataacaga tcccacttaa cagagaggaa     1200

aactgaggca gggagagggg aagagactca tttagggatg tggccaggca gcaacaagag     1260

cctaggtctc ctggctgtga tccaggaata tctctgctga gatgcaggag gagacgctag     1320

aagcagccat tgcaaagctg ggtgacgggg agagcttacc gccagccaca agcgtctctc     1380

tgccagcctt gccctgtctc ccccatgtcc aggctgctgc ctcggtccca ttctcaggga     1440

atctctggcc attgttgggt gtttgttgca ttcaataatc acagatcact cagttctggc     1500

cagaaggtgg gtgtgccact tacgggtggt tgttctctgc agggtcagtc ccagtttaca     1560

aatattgtcc ctttcactgt taggaatgtc ccagtttggt tgattaacta tatggccact     1620

ctccctatgg aacttcatgg ggtggtgagc aggacagatg tctgaattcc atcatttcct     1680

tcttcttcct ctgggcaaaa cattgcacat tgcttcatgg ctcctaggag aggcccccac     1740

atgtccgggt tatttcattt cccgagaagg gagagggagg aaggactgcc aattctgggt     1800

ttccaccacc tctgcattcc ttcccaacaa ggaactctgc cccacattag gatgcattct     1860

tctgctaaac acacacacac acacacacac acacaacaca cacacacaca cacacacaca     1920

cacacacaca aaactcccta ccgggttccc agttcaatcc tgaccccctg atctgattcg     1980

tgtcccttat gggcccagag cgctaagcaa ataacttccc ccattccctg gaatttcttt     2040

gcccagctct cctcagcgtg tggtccctct gccccttccc cctcctccca gcaccaagct     2100

ctctccttcc ccaaggcctc ctcaaatccc tctcccactc ctggttgcct tcctagctac     2160

cctctccctg tctagggggg agtgcaccct ccttaggcag tggggtctgt gctgaccgcc     2220

tgctgactgc cttgcaggtg aaattgccct gtggtccttg gtggtcctgg ccatcgagcg     2280

gtacgtggtg gtgtgtaagc ccatgagcaa cttccgcttc ggggagaacc atgccatcat     2340

gggcgttgcc ttcacctggg tcatggcgct ggcctgcgcc gcacccccac tcgccggctg     2400

gtccaggtaa tggcactgag cagaagggaa gaagctccgg gggctctttg tagggtcctc     2460

cagtcaggac tcaaacccag tagtgtctgg ttccaggcac tgaccttgta tgtctcctgg     2520

cccaaatgcc cactcagggt aggggtgtag ggcagaagaa gaaacagact ctaatgttgc     2580

tacaagggct ggtcccatct cctgagcccc atgtcaaaca gaatccaaga catcccaacc     2640

cttcaccttg gctgtgcccc taatcctcaa ctaagctagg cgcaaattcc aatcctcttt     2700

ggtctagtac cccgggggca gccccctcta accttgggcc tcagcagcag gggaggccac     2760

accttcctag tgcaggtggc catattgtgg ccccttggaa ctgggtccca ctcagcctct     2820

aggcgattgt ctcctaatgg ggctgagatg agacacagtg gggacagtgg tttggacaat     2880

aggactggtg actctggtcc ccagaggcct catgtccctc tgtctccaga aaattcccac     2940

tctcacttcc ctttcctcct cagtcttgct agggtccatt tcttacccct tgctgaattt     3000

gagcccaccc cctggacttt ttccccatct tctccaatct ggcctagttc tatcctctgg     3060

aagcagagcc gctggacgct ctgggtttcc tgaggcccgt ccactgtcac caatatcagg     3120

aaccattgcc acgtcctaat gacgtgcgct ggaagcctct agtttccaga agctgcacaa     3180

agatccctta gatactctgt gtgtccatct ttggcctgga aaatactctc accctggggc     3240

taggaagacc tcggtttgta caaacttcct caaatgcaga gcctgagggc tctccccacc     3300

tcctcaccaa ccctctgcgt ggcatagccc tagcctcagc gggcagtgga tgctggggct     3360

gggcatgcag ggagaggctg ggtggtgtca tctggtaacg cagccaccaa acaatgaagc     3420

gacactgatt ccacaaggtg catctgcatc cccatctgat ccattccatc ctgtcaccca     3480

gccatgcaga cgtttatgat ccccttttcc agggagggaa tgtgaagccc cagaaagggc     3540

cagcgctcgg cagccacctt ggctgttccc aagtccctca caggcagggt ctccctacct     3600

gcctgtcctc aggtacatcc ccgagggcct gcagtgctcg tgtggaatcg actactacac     3660

gctcaagccg gaggtcaaca acgagtcttt tgtcatctac atgttcgtgg tccacttcac     3720

catccccatg attatcatct ttttctgcta tgggcagctc gtcttcaccg tcaaggaggt     3780

acgggccggg gggtgggcgg cctcacggct ctgagggtcc agcccccagc atgcatctgc     3840

ggctcctgct ccctggagga gccatggtct ggacccgggt cccgtgtcct gcaggccgct     3900

gcccagcagc aggagtcagc caccacacag aaggcagaga aggaggtcac ccgcatggtc     3960

atcatcatgg tcatcgcttt cctgatctgc tgggtgccct acgccagcgt ggcattctac     4020

atcttcaccc accagggctc caacttcggt cccatcttca tgaccatccc agcgttcttt     4080

gccaagagcg ccgccatcta caaccctgtc atctatatca tgatgaacaa gcaggtgcct     4140

actgcgggtg ggagggcccc agtgccccag gccacaggcg ctgcctgcca aggacaagct     4200

acttcccagg gcaggggagg gggctccatc agggttactg gcagcagtct tgggtcagca     4260

gtcccaatgg ggagtgtgtg agaaatgcag attcctggcc ccactcagaa ctgctgaatc     4320

tcagggtggg cccaggaacc tgcatttcca gcaagccctc cacaggtggc tcagatgctc     4380

actcaggtgg gagaagctcc agtcagctag ttctggaagc ccaatgtcaa agtcagaagg     4440

acccaagtcg ggaatgggat gggccagtct ccataaagct gaataaggag ctaaaaagtc     4500

ttattctgag gggtaaaggg gtaaagggtt cctcggagag gtacctccga ggggtaaaca     4560

gttgggtaaa cagtctctga agtcagctct gccattttct agctgtatgg ccctgggcaa     4620

gtcaatttcc ttctctgtgc tttggtttcc tcatccatag aaaggtagaa agggcaaaac     4680

accaaactct tggattacaa gagataattt acagaacacc cttggcacac agagggcacc     4740

atgaaatgtc acgggtgaca cagccccctt gtgctcagtc cctggcatct ctaggggtga     4800

ggagcgtctg cctagcaggt tccctccagg aagctggatt tgagtggatg gggcgctgga     4860

atcgtgaggg gcagaagcag gcaaagggtc ggggcgaacc tcactaacgt gccagttcca     4920

agcacactgt gggcagccct ggccctgact caagcctctt gccttccagt tccggaactg     4980

catgctcacc accatctgct gcggcaagaa cccactgggt gacgatgagg cctctgctac     5040

cgtgtccaag acggagacga gccaggtggc cccggcctaa gacctgccta ggactctgtg     5100

gccgactata ggcgtctccc atcccctaca ccttccccca gccacagcca tcccaccagg     5160

agcagcgcct gtgcagaatg aacgaagtca cataggctcc ttaatttttt tttttttttt     5220

aagaaataat taatgaggct cctcactcac ctgggacagc ctgagaaggg acatccacca     5280

agacctactg atctggagtc ccacgttccc caaggccagc gggatgtgtg cccctcctcc     5340

tcccaactca tctttcagga acacgaggat tcttgctttc tggaaaagtg tcccagctta     5400

gggataagtg tctagcacag aatggggcac acagtaggtg cttaataaat gctggatgga     5460

tgcaggaagg aatggaggaa tgaatgggaa gggagaacat atctatcctc tcagaccctc     5520

gcagcagcag caactcatac ttggctaatg atatggagca gttgtttttc cctccctggg     5580

cctcactttc ttctcctata aaatggaaat cccagatccc tggtcctgcc gacacgcagc     5640

tactgagaag accaaaagag gtgtgtgtgt gtctatgtgt gtgtttcagc actttgtaaa     5700

tagcaagaag ctgtacagat tctagttaat gttgtgaata acatcaatta atgtaactag     5760

ttaattacta tgattatcac ctcctgatag tgaacatttt gagattgggc attcagatga     5820

tggggtttca cccaaccttg gggcaggttt ttaaaaatta gctaggcatc aaggccagac     5880

cagggctggg ggttgggctg taggcaggga cagtcacagg aatgcagaat gcagtcatca     5940

gacctgaaaa aacaacactg ggggaggggg acggtgaagg ccaagttccc aatgagggtg     6000

agattgggcc tggggtctca cccctagtgt ggggccccag gtcccgtgcc tccccttccc     6060

aatgtggcct atggagagac aggcctttct ctcagcctct ggaagccacc tgctcttttg     6120

ctctagcacc tgggtcccag catctagagc atggagcctc tagaagccat gctcacccgc     6180

ccacatttaa ttaacagctg agtccctgat gtcatcctta tctcgaagag cttagaaaca     6240

aagagtggga aattccactg ggcctacctt ccttggggat gttcatgggc cccagtttcc     6300

agtttccctt gccagacaag cccatcttca gcagttgcta gtccattctc cattctggag     6360

aatctgctcc aaaaagctgg ccacatctct gaggtgtcag aattaagctg cctcagtaac     6420

tgctccccct tctccatata agcaaagcca gaagctctag ctttacccag ctctgcctgg     6480

agactaaggc aaattgggcc attaaaagct cagctcctat gttggtatta acggtggtgg     6540

gttttgttgc tttcacactc tatccacagg atagattgaa actgccagct tccacctgat     6600

ccctgaccct gggatggctg gattgagcaa tgagcagagc caagcagcac agagtcccct     6660

ggggctagag gtggaggagg cagtcctggg aatgggaaaa acccca                    6706


<210>  2
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild-type RHO cDNA

<400>  2
atgaatggca cagaaggccc taacttctac gtgcccttct ccaatgcgac gggtgtggta       60

cgcagcccct tcgagtaccc acagtactac ctggctgagc catggcagtt ctccatgctg      120

gccgcctaca tgtttctgct gatcgtgctg ggcttcccca tcaacttcct cacgctctac      180

gtcaccgtcc agcacaagaa gctgcgcacg cctctcaact acatcctgct caacctagcc      240

gtggctgacc tcttcatggt cctaggtggc ttcaccagca ccctctacac ctctctgcat      300

ggatacttcg tcttcgggcc cacaggatgc aatttggagg gcttctttgc caccctgggc      360

ggtgaaattg ccctgtggtc cttggtggtc ctggccatcg agcggtacgt ggtggtgtgt      420

aagcccatga gcaacttccg cttcggggag aaccatgcca tcatgggcgt tgccttcacc      480

tgggtcatgg cgctggcctg cgccgcaccc ccactcgccg gctggtccag gtacatcccc      540

gagggcctgc agtgctcgtg tggaatcgac tactacacgc tcaagccgga ggtcaacaac      600

gagtcttttg tcatctacat gttcgtggtc cacttcacca tccccatgat tatcatcttt      660

ttctgctatg ggcagctcgt cttcaccgtc aaggaggccg ctgcccagca gcaggagtca      720

gccaccacac agaaggcaga gaaggaggtc acccgcatgg tcatcatcat ggtcatcgct      780

ttcctgatct gctgggtgcc ctacgccagc gtggcattct acatcttcac ccaccagggc      840

tccaacttcg gtcccatctt catgaccatc ccagcgttct ttgccaagag cgccgccatc      900

tacaaccctg tcatctatat catgatgaac aagcagttcc ggaactgcat gctcaccacc      960

atctgctgcg gcaagaaccc actgggtgac gatgaggcct ctgctaccgt gtccaagacg     1020

gagacgagcc aggtggcccc ggcctaa                                         1047


<210>  3

<400>  3
000

<210>  4
<211>  2828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO cDNA with intron 1

<400>  4
atgaatggca cagaaggccc taacttctac gtgcccttct ccaatgcgac gggtgtggta       60

cgcagcccct tcgagtaccc acagtactac ctggctgagc catggcagtt ctccatgctg      120

gccgcctaca tgtttctgct gatcgtgctg ggcttcccca tcaacttcct cacgctctac      180

gtcaccgtcc agcacaagaa gctgcgcacg cctctcaact acatcctgct caacctagcc      240

gtggctgacc tcttcatggt cctaggtggc ttcaccagca ccctctacac ctctctgcat      300

ggatacttcg tcttcgggcc cacaggatgc aatttggagg gcttctttgc caccctgggc      360

ggtatgagcc gggtgtgggt ggggtgtgca ggagcccggg agcatggagg ggtctgggag      420

agtcccgggc ttggcggtgg tggctgagag gccttctccc ttctcctgtc ctgtcaatgt      480

tatccaaagc cctcatatat tcagtcaaca aacaccattc atggtgatag ccgggctgct      540

gtttgtgcag ggctggcact gaacactgcc ttgatcttat ttggagcaat atgcgcttgt      600

ctaatttcac agcaagaaaa ctgagctgag gctcaaagaa gtcaagcgcc ctgctggggc      660

gtcacacagg gacgggtgca gagttgagtt ggaagcccgc atctatctcg ggccatgttt      720

gcagcaccaa gcctctgttt cccttggagc agctgtgctg agtcagaccc aggctgggca      780

ctgagggaga gctgggcaag ccagacccct cctctctggg ggcccaagct cagggtggga      840

agtggatttt ccattctcca gtcattgggt cttccctgtg ctgggcaatg ggctcggtcc      900

cctctggcat cctctgcctc ccctctcagc ccctgtcctc aggtgcccct ccagcctccc      960

tgccgcgttc caagtctcct ggtgttgaga accgcaagca gccgctctga agcagttcct     1020

ttttgcttta gaataatgtc ttgcatttaa caggaaaaca gatggggtgc tgcagggata     1080

acagatccca cttaacagag aggaaaactg aggcagggag aggggaagag actcatttag     1140

ggatgtggcc aggcagcaac aagagcctag gtctcctggc tgtgatccag gaatatctct     1200

gctgagatgc aggaggagac gctagaagca gccattgcaa agctgggtga cggggagagc     1260

ttaccgccag ccacaagcgt ctctctgcca gccttgccct gtctccccca tgtccaggct     1320

gctgcctcgg tcccattctc agggaatctc tggccattgt tgggtgtttg ttgcattcaa     1380

taatcacaga tcactcagtt ctggccagaa ggtgggtgtg ccacttacgg gtggttgttc     1440

tctgcagggt cagtcccagt ttacaaatat tgtccctttc actgttagga atgtcccagt     1500

ttggttgatt aactatatgg ccactctccc tatggaactt catggggtgg tgagcaggac     1560

agatgtctga attccatcat ttccttcttc ttcctctggg caaaacattg cacattgctt     1620

catggctcct aggagaggcc cccacatgtc cgggttattt catttcccga gaagggagag     1680

ggaggaagga ctgccaattc tgggtttcca ccacctctgc attccttccc aacaaggaac     1740

tctgccccac attaggatgc attcttctgc taaacacaca cacacacaca cacacacaca     1800

acacacacac acacacacac acacacacac acacaaaact ccctaccggg ttcccagttc     1860

aatcctgacc ccctgatctg attcgtgtcc cttatgggcc cagagcgcta agcaaataac     1920

ttcccccatt ccctggaatt tctttgccca gctctcctca gcgtgtggtc cctctgcccc     1980

ttccccctcc tcccagcacc aagctctctc cttccccaag gcctcctcaa atccctctcc     2040

cactcctggt tgccttccta gctaccctct ccctgtctag gggggagtgc accctcctta     2100

ggcagtgggg tctgtgctga ccgcctgctg actgccttgc aggtgaaatt gccctgtggt     2160

ccttggtggt cctggccatc gagcggtacg tggtggtgtg taagcccatg agcaacttcc     2220

gcttcgggga gaaccatgcc atcatgggcg ttgccttcac ctgggtcatg gcgctggcct     2280

gcgccgcacc cccactcgcc ggctggtcca ggtacatccc cgagggcctg cagtgctcgt     2340

gtggaatcga ctactacacg ctcaagccgg aggtcaacaa cgagtctttt gtcatctaca     2400

tgttcgtggt ccacttcacc atccccatga ttatcatctt tttctgctat gggcagctcg     2460

tcttcaccgt caaggaggcc gctgcccagc agcaggagtc agccaccaca cagaaggcag     2520

agaaggaggt cacccgcatg gtcatcatca tggtcatcgc tttcctgatc tgctgggtgc     2580

cctacgccag cgtggcattc tacatcttca cccaccaggg ctccaacttc ggtcccatct     2640

tcatgaccat cccagcgttc tttgccaaga gcgccgccat ctacaaccct gtcatctata     2700

tcatgatgaa caagcagttc cggaactgca tgctcaccac catctgctgc ggcaagaacc     2760

cactgggtga cgatgaggcc tctgctaccg tgtccaagac ggagacgagc caggtggccc     2820

cggcctaa                                                              2828


<210>  5
<211>  2253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO cDNA with intron 2

<400>  5
atgaatggca cagaaggccc taacttctac gtgcccttct ccaatgcgac gggtgtggta       60

cgcagcccct tcgagtaccc acagtactac ctggctgagc catggcagtt ctccatgctg      120

gccgcctaca tgtttctgct gatcgtgctg ggcttcccca tcaacttcct cacgctctac      180

gtcaccgtcc agcacaagaa gctgcgcacg cctctcaact acatcctgct caacctagcc      240

gtggctgacc tcttcatggt cctaggtggc ttcaccagca ccctctacac ctctctgcat      300

ggatacttcg tcttcgggcc cacaggatgc aatttggagg gcttctttgc caccctgggc      360

ggtgaaattg ccctgtggtc cttggtggtc ctggccatcg agcggtacgt ggtggtgtgt      420

aagcccatga gcaacttccg cttcggggag aaccatgcca tcatgggcgt tgccttcacc      480

tgggtcatgg cgctggcctg cgccgcaccc ccactcgccg gctggtccag gtaatggcac      540

tgagcagaag ggaagaagct ccgggggctc tttgtagggt cctccagtca ggactcaaac      600

ccagtagtgt ctggttccag gcactgacct tgtatgtctc ctggcccaaa tgcccactca      660

gggtaggggt gtagggcaga agaagaaaca gactctaatg ttgctacaag ggctggtccc      720

atctcctgag ccccatgtca aacagaatcc aagacatccc aacccttcac cttggctgtg      780

cccctaatcc tcaactaagc taggcgcaaa ttccaatcct ctttggtcta gtaccccggg      840

ggcagccccc tctaaccttg ggcctcagca gcaggggagg ccacaccttc ctagtgcagg      900

tggccatatt gtggcccctt ggaactgggt cccactcagc ctctaggcga ttgtctccta      960

atggggctga gatgagacac agtggggaca gtggtttgga caataggact ggtgactctg     1020

gtccccagag gcctcatgtc cctctgtctc cagaaaattc ccactctcac ttccctttcc     1080

tcctcagtct tgctagggtc catttcttac cccttgctga atttgagccc accccctgga     1140

ctttttcccc atcttctcca atctggccta gttctatcct ctggaagcag agccgctgga     1200

cgctctgggt ttcctgaggc ccgtccactg tcaccaatat caggaaccat tgccacgtcc     1260

taatgacgtg cgctggaagc ctctagtttc cagaagctgc acaaagatcc cttagatact     1320

ctgtgtgtcc atctttggcc tggaaaatac tctcaccctg gggctaggaa gacctcggtt     1380

tgtacaaact tcctcaaatg cagagcctga gggctctccc cacctcctca ccaaccctct     1440

gcgtggcata gccctagcct cagcgggcag tggatgctgg ggctgggcat gcagggagag     1500

gctgggtggt gtcatctggt aacgcagcca ccaaacaatg aagcgacact gattccacaa     1560

ggtgcatctg catccccatc tgatccattc catcctgtca cccagccatg cagacgttta     1620

tgatcccctt ttccagggag ggaatgtgaa gccccagaaa gggccagcgc tcggcagcca     1680

ccttggctgt tcccaagtcc ctcacaggca gggtctccct acctgcctgt cctcaggtac     1740

atccccgagg gcctgcagtg ctcgtgtgga atcgactact acacgctcaa gccggaggtc     1800

aacaacgagt cttttgtcat ctacatgttc gtggtccact tcaccatccc catgattatc     1860

atctttttct gctatgggca gctcgtcttc accgtcaagg aggccgctgc ccagcagcag     1920

gagtcagcca ccacacagaa ggcagagaag gaggtcaccc gcatggtcat catcatggtc     1980

atcgctttcc tgatctgctg ggtgccctac gccagcgtgg cattctacat cttcacccac     2040

cagggctcca acttcggtcc catcttcatg accatcccag cgttctttgc caagagcgcc     2100

gccatctaca accctgtcat ctatatcatg atgaacaagc agttccggaa ctgcatgctc     2160

accaccatct gctgcggcaa gaacccactg ggtgacgatg aggcctctgc taccgtgtcc     2220

aagacggaga cgagccaggt ggccccggcc taa                                  2253


<210>  6
<211>  1163
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO cDNA with intron 3

<400>  6
atgaatggca cagaaggccc taacttctac gtgcccttct ccaatgcgac gggtgtggta       60

cgcagcccct tcgagtaccc acagtactac ctggctgagc catggcagtt ctccatgctg      120

gccgcctaca tgtttctgct gatcgtgctg ggcttcccca tcaacttcct cacgctctac      180

gtcaccgtcc agcacaagaa gctgcgcacg cctctcaact acatcctgct caacctagcc      240

gtggctgacc tcttcatggt cctaggtggc ttcaccagca ccctctacac ctctctgcat      300

ggatacttcg tcttcgggcc cacaggatgc aatttggagg gcttctttgc caccctgggc      360

ggtgaaattg ccctgtggtc cttggtggtc ctggccatcg agcggtacgt ggtggtgtgt      420

aagcccatga gcaacttccg cttcggggag aaccatgcca tcatgggcgt tgccttcacc      480

tgggtcatgg cgctggcctg cgccgcaccc ccactcgccg gctggtccag gtacatcccc      540

gagggcctgc agtgctcgtg tggaatcgac tactacacgc tcaagccgga ggtcaacaac      600

gagtcttttg tcatctacat gttcgtggtc cacttcacca tccccatgat tatcatcttt      660

ttctgctatg ggcagctcgt cttcaccgtc aaggaggtac gggccggggg gtgggcggcc      720

tcacggctct gagggtccag cccccagcat gcatctgcgg ctcctgctcc ctggaggagc      780

catggtctgg acccgggtcc cgtgtcctgc aggccgctgc ccagcagcag gagtcagcca      840

ccacacagaa ggcagagaag gaggtcaccc gcatggtcat catcatggtc atcgctttcc      900

tgatctgctg ggtgccctac gccagcgtgg cattctacat cttcacccac cagggctcca      960

acttcggtcc catcttcatg accatcccag cgttctttgc caagagcgcc gccatctaca     1020

accctgtcat ctatatcatg atgaacaagc agttccggaa ctgcatgctc accaccatct     1080

gctgcggcaa gaacccactg ggtgacgatg aggcctctgc taccgtgtcc aagacggaga     1140

cgagccaggt ggccccggcc taa                                             1163


<210>  7
<211>  1882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO cDNA with intron 4

<400>  7
atgaatggca cagaaggccc taacttctac gtgcccttct ccaatgcgac gggtgtggta       60

cgcagcccct tcgagtaccc acagtactac ctggctgagc catggcagtt ctccatgctg      120

gccgcctaca tgtttctgct gatcgtgctg ggcttcccca tcaacttcct cacgctctac      180

gtcaccgtcc agcacaagaa gctgcgcacg cctctcaact acatcctgct caacctagcc      240

gtggctgacc tcttcatggt cctaggtggc ttcaccagca ccctctacac ctctctgcat      300

ggatacttcg tcttcgggcc cacaggatgc aatttggagg gcttctttgc caccctgggc      360

ggtgaaattg ccctgtggtc cttggtggtc ctggccatcg agcggtacgt ggtggtgtgt      420

aagcccatga gcaacttccg cttcggggag aaccatgcca tcatgggcgt tgccttcacc      480

tgggtcatgg cgctggcctg cgccgcaccc ccactcgccg gctggtccag gtacatcccc      540

gagggcctgc agtgctcgtg tggaatcgac tactacacgc tcaagccgga ggtcaacaac      600

gagtcttttg tcatctacat gttcgtggtc cacttcacca tccccatgat tatcatcttt      660

ttctgctatg ggcagctcgt cttcaccgtc aaggaggccg ctgcccagca gcaggagtca      720

gccaccacac agaaggcaga gaaggaggtc acccgcatgg tcatcatcat ggtcatcgct      780

ttcctgatct gctgggtgcc ctacgccagc gtggcattct acatcttcac ccaccagggc      840

tccaacttcg gtcccatctt catgaccatc ccagcgttct ttgccaagag cgccgccatc      900

tacaaccctg tcatctatat catgatgaac aagcaggtgc ctactgcggg tgggagggcc      960

ccagtgcccc aggccacagg cgctgcctgc caaggacaag ctacttccca gggcagggga     1020

gggggctcca tcagggttac tggcagcagt cttgggtcag cagtcccaat ggggagtgtg     1080

tgagaaatgc agattcctgg ccccactcag aactgctgaa tctcagggtg ggcccaggaa     1140

cctgcatttc cagcaagccc tccacaggtg gctcagatgc tcactcaggt gggagaagct     1200

ccagtcagct agttctggaa gcccaatgtc aaagtcagaa ggacccaagt cgggaatggg     1260

atgggccagt ctccataaag ctgaataagg agctaaaaag tcttattctg aggggtaaag     1320

gggtaaaggg ttcctcggag aggtacctcc gaggggtaaa cagttgggta aacagtctct     1380

gaagtcagct ctgccatttt ctagctgtat ggccctgggc aagtcaattt ccttctctgt     1440

gctttggttt cctcatccat agaaaggtag aaagggcaaa acaccaaact cttggattac     1500

aagagataat ttacagaaca cccttggcac acagagggca ccatgaaatg tcacgggtga     1560

cacagccccc ttgtgctcag tccctggcat ctctaggggt gaggagcgtc tgcctagcag     1620

gttccctcca ggaagctgga tttgagtgga tggggcgctg gaatcgtgag gggcagaagc     1680

aggcaaaggg tcggggcgaa cctcactaac gtgccagttc caagcacact gtgggcagcc     1740

ctggccctga ctcaagcctc ttgccttcca gttccggaac tgcatgctca ccaccatctg     1800

ctgcggcaag aacccactgg gtgacgatga ggcctctgct accgtgtcca agacggagac     1860

gagccaggtg gccccggcct aa                                              1882


<210>  8
<211>  1670
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector 2

<400>  8
ccacgtcaga atcaaaccct caccttaacc tcattagcgt tgggcataat caccaggcca       60

agcgccttaa actacgagag gccccatccc acccgccctg ccttagccct gccacgtgtg      120

ccaaacgctg ttagacccaa caccacccag gccaggtagg gggctggagc ccaggtgggc      180

atttgagtca ccaaccccca ggcagtctcc cttttcctgg atcctgagta cctctcctcc      240

ctgacctcag gcttcctcct agtgtcacct tggcccctct tagaagccaa ttaggccctc      300

agtttctgca gcggggatta atatgattat gaacaccccc aatctcccag atgctgattc      360

agccaggagc ttaggagggg gaggtcactt tataagggtc tgggggggtc agaacccaga      420

gtcatccagc tggagccctg agtggctgag ctcaggcctt cgcagcattc ttgggtggga      480

gcagccacgg gtcagccaca agggccacca ccatgaatgg cacagaaggc cctaacttct      540

acgtgccctt ctccaatgcg acgggtgtgg tacgcagccc cttcgagtac ccacagtact      600

acctggctga gccatggcag ttctccatgc tggccgccta catgtttctg ctgatcgtgc      660

tgggcttccc catcaacttc ctcacgctct acgtcaccgt ccagcacaag aagctgcgca      720

cgcctctcaa ctacatcctg ctcaacctag ccgtggctga cctcttcatg gtcctaggtg      780

gcttcaccag caccctctac acctctctgc atggatactt cgtcttcggg cccacaggat      840

gcaatttgga gggcttcttt gccaccctgg gcggtgaaat tgccctgtgg tccttggtgg      900

tcctggccat cgagcggtac gtggtggtgt gtaagcccat gagcaacttc cgcttcgggg      960

agaaccatgc catcatgggc gttgccttca cctgggtcat ggcgctggcc tgcgccgcac     1020

ccccactcgc cggctggtcc aggtacatcc ccgagggcct gcagtgctcg tgtggaatcg     1080

actactacac gctcaagccg gaggtcaaca acgagtcttt tgtcatctac atgttcgtgg     1140

tccacttcac catccccatg attatcatct ttttctgcta tgggcagctc gtcttcaccg     1200

tcaaggaggc cgctgcccag cagcaggagt cagccaccac acagaaggca gagaaggagg     1260

tcacccgcat ggtcatcatc atggtcatcg ctttcctgat ctgctgggtg ccctacgcca     1320

gcgtggcatt ctacatcttc acccaccagg gctccaactt cggtcccatc ttcatgacca     1380

tcccagcgtt ctttgccaag agcgccgcca tctacaaccc tgtcatctat atcatgatga     1440

acaagcagtt ccggaactgc atgctcacca ccatctgctg cggcaagaac ccactgggtg     1500

acgatgaggc ctctgctacc gtgtccaaga cggagacgag ccaggtggcc ccggcctaag     1560

ctggagcctc ggtggccatg cttcttgccc cttgggcctc cccccagccc ctcctcccct     1620

tcctgcaccc gtacccccgt ggtctttgaa taaagtctga gtgggcggca                1670


<210>  9
<211>  4498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector 1: 550 bp minimal RHO promoter driving wt Cas9 with SV40 
       polyA signal


<220>
<221>  misc_feature
<222>  (1)..(141)
<223>  ITR

<220>
<221>  misc_feature
<222>  (172)..(796)
<223>  MinRHO promoter

<220>
<221>  misc_feature
<222>  (797)..(960)
<223>  SV40 SA/SD

<220>
<221>  misc_feature
<222>  (964)..(976)
<223>  Kozak start

<220>
<221>  misc_feature
<222>  (979)..(1008)
<223>  NLS

<220>
<221>  misc_feature
<222>  (1009)..(4167)
<223>  Sa Cas9

<220>
<221>  misc_feature
<222>  (4174)..(4194)
<223>  SV40 NLS

<220>
<221>  misc_feature
<222>  (4201)..(4260)
<223>  Minimal polyA

<220>
<221>  misc_feature
<222>  (4358)..(4498)
<223>  ITR

<400>  9
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc taagcggccg cggttcctca gatctgaatt ctcatgttac      180

aggcagggag acgggcacaa aacacaaata aaaagcttcc atgctgtcag aagcactatg      240

caaaaagcaa gatgctgagg tcatggagct cctcctgtca gaggagtgtg gggactggat      300

gactccagag gtaacttgtg ggggaacgaa caggtaaggg gctgtgtgac gagatgagag      360

actgggagaa taaaccagaa agtctctagc tgtccagagg acatagcaca gaggcccatg      420

gtccctattt caaacccagg ccaccagact gagctgggac cttgggacag acaagtcatg      480

cagaagttag gggaccttct cctccctttt cctggatcct gagtacctct cctccctgac      540

ctcaggcttc ctcctagtgt caccttggcc cctcttagaa gccaattagg ccctcagttt      600

ctgcagcggg gattaatatg attatgaaca cccccaatct cccagatgct gattcagcca      660

ggagcttagg agggggaggt cactttataa gggtctgggg gggtcagaac ccagagtcat      720

ccagctggag ccctgagtgg ctgagctcag gccttcgcag cattcttggg tgggagcagc      780

cacgggtcag ccacaatcta gaggatccgg tactcgagga actgaaaaac cagaaagtta      840

actggtaagt ttagtctttt tgtcttttat ttcaggtccc ggatccggtg gtggtgcaaa      900

tcaaagaact gctcctcagt ggatgttgcc tttacttcta ggcctgtacg gaagtgttac      960

gcggccgcca ccatgggacc gaagaaaaag cgcaaggtcg aagcgtccat gaaaaggaac     1020

tacattctgg ggctggacat cgggattaca agcgtggggt atgggattat tgactatgaa     1080

acaagggacg tgatcgacgc aggcgtcaga ctgttcaagg aggccaacgt ggaaaacaat     1140

gagggacgga gaagcaagag gggagccagg cgcctgaaac gacggagaag gcacagaatc     1200

cagagggtga agaaactgct gttcgattac aacctgctga ccgaccattc tgagctgagt     1260

ggaattaatc cttatgaagc cagggtgaaa ggcctgagtc agaagctgtc agaggaagag     1320

ttttccgcag ctctgctgca cctggctaag cgccgaggag tgcataacgt caatgaggtg     1380

gaagaggaca ccggcaacga gctgtctaca aaggaacaga tctcacgcaa tagcaaagct     1440

ctggaagaga agtatgtcgc agagctgcag ctggaacggc tgaagaaaga tggcgaggtg     1500

agagggtcaa ttaataggtt caagacaagc gactacgtca aagaagccaa gcagctgctg     1560

aaagtgcaga aggcttacca ccagctggat cagagcttca tcgatactta tatcgacctg     1620

ctggagactc ggagaaccta ctatgaggga ccaggagaag ggagcccctt cggatggaaa     1680

gacatcaagg aatggtacga gatgctgatg ggacattgca cctattttcc agaagagctg     1740

agaagcgtca agtacgctta taacgcagat ctgtacaacg ccctgaatga cctgaacaac     1800

ctggtcatca ccagggatga aaacgagaaa ctggaatact atgagaagtt ccagatcatc     1860

gaaaacgtgt ttaagcagaa gaaaaagcct acactgaaac agattgctaa ggagatcctg     1920

gtcaacgaag aggacatcaa gggctaccgg gtgacaagca ctggaaaacc agagttcacc     1980

aatctgaaag tgtatcacga tattaaggac atcacagcac ggaaagaaat cattgagaac     2040

gccgaactgc tggatcagat tgctaagatc ctgactatct accagagctc cgaggacatc     2100

caggaagagc tgactaacct gaacagcgag ctgacccagg aagagatcga acagattagt     2160

aatctgaagg ggtacaccgg aacacacaac ctgtccctga aagctatcaa tctgattctg     2220

gatgagctgt ggcatacaaa cgacaatcag attgcaatct ttaaccggct gaagctggtc     2280

ccaaaaaagg tggacctgag tcagcagaaa gagatcccaa ccacactggt ggacgatttc     2340

attctgtcac ccgtggtcaa gcggagcttc atccagagca tcaaagtgat caacgccatc     2400

atcaagaagt acggcctgcc caatgatatc attatcgagc tggctaggga gaagaacagc     2460

aaggacgcac agaagatgat caatgagatg cagaaacgaa accggcagac caatgaacgc     2520

attgaagaga ttatccgaac taccgggaaa gagaacgcaa agtacctgat tgaaaaaatc     2580

aagctgcacg atatgcagga gggaaagtgt ctgtattctc tggaggccat ccccctggag     2640

gacctgctga acaatccatt caactacgag gtcgatcata ttatccccag aagcgtgtcc     2700

ttcgacaatt cctttaacaa caaggtgctg gtcaagcagg aagagaactc taaaaagggc     2760

aataggactc ctttccagta cctgtctagt tcagattcca agatctctta cgaaaccttt     2820

aaaaagcaca ttctgaatct ggccaaagga aagggccgca tcagcaagac caaaaaggag     2880

tacctgctgg aagagcggga catcaacaga ttctccgtcc agaaggattt tattaaccgg     2940

aatctggtgg acacaagata cgctactcgc ggcctgatga atctgctgcg atcctatttc     3000

cgggtgaaca atctggatgt gaaagtcaag tccatcaacg gcgggttcac atcttttctg     3060

aggcgcaaat ggaagtttaa aaaggagcgc aacaaagggt acaagcacca tgccgaagat     3120

gctctgatta tcgcaaatgc cgacttcatc tttaaggagt ggaaaaagct ggacaaagcc     3180

aagaaagtga tggagaacca gatgttcgaa gagaagcagg ccgaatctat gcccgaaatc     3240

gagacagaac aggagtacaa ggagattttc atcactcctc accagatcaa gcatatcaag     3300

gatttcaagg actacaagta ctctcaccgg gtggataaaa agcccaacag agagctgatc     3360

aatgacaccc tgtatagtac aagaaaagac gataagggga ataccctgat tgtgaacaat     3420

ctgaacggac tgtacgacaa agataatgac aagctgaaaa agctgatcaa caaaagtccc     3480

gagaagctgc tgatgtacca ccatgatcct cagacatatc agaaactgaa gctgattatg     3540

gagcagtacg gcgacgagaa gaacccactg tataagtact atgaagagac tgggaactac     3600

ctgaccaagt atagcaaaaa ggataatggc cccgtgatca agaagatcaa gtactatggg     3660

aacaagctga atgcccatct ggacatcaca gacgattacc ctaacagtcg caacaaggtg     3720

gtcaagctgt cactgaagcc atacagattc gatgtctatc tggacaacgg cgtgtataaa     3780

tttgtgactg tcaagaatct ggatgtcatc aaaaaggaga actactatga agtgaatagc     3840

aagtgctacg aagaggctaa aaagctgaaa aagattagca accaggcaga gttcatcgcc     3900

tccttttaca acaacgacct gattaagatc aatggcgaac tgtatagggt catcggggtg     3960

aacaatgatc tgctgaaccg cattgaagtg aatatgattg acatcactta ccgagagtat     4020

ctggaaaaca tgaatgataa gcgcccccct cgaattatca aaacaattgc ctctaagact     4080

cagagtatca aaaagtactc aaccgacatt ctgggaaacc tgtatgaggt gaagagcaaa     4140

aagcaccctc agattatcaa aaagggcgga tcccccaaga agaagaggaa agtctcgagc     4200

tagcaataaa ggatcgttta ttttcattgg aagcgtgtgt tggttttttg atcaggcgcg     4260

tccaagcttg catgctgggg agagatctgc ggccgcctag caataaagga tcgtttattt     4320

tcattggaag cgtgtgttgg ttttttgatc aggcgcgagg aacccctagt gatggagttg     4380

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga     4440

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg cctgcagg       4498


<210>  10
<211>  4170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 Vector 2: 250 bp minimal RHO promoter driving Cas9 w/ alpha 
       globin UTR


<220>
<221>  misc_feature
<222>  (1)..(141)
<223>  ITR

<220>
<221>  misc_feature
<222>  (179)..(427)
<223>  MinRHO promoter (250bp)

<220>
<221>  misc_feature
<222>  (428)..(590)
<223>  SV40 intron

<220>
<221>  misc_feature
<222>  (607)..(636)
<223>  NLS

<220>
<221>  misc_feature
<222>  (637)..(3795)
<223>  Sa Cas9

<220>
<221>  misc_feature
<222>  (3802)..(3822)
<223>  SV40 NLS

<220>
<221>  misc_feature
<222>  (3832)..(3942)
<223>  HBA1 UTR

<220>
<221>  misc_feature
<222>  (4030)..(4170)
<223>  ITR

<400>  10
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc taagcggccg cggttcctca gatctgaatt cggtacctgt      180

caccttggcc cctcttagaa gccaattagg ccctcagttt ctgcagcggg gattaatatg      240

attatgaaca cccccaatct cccagatgct gattcagcca ggagcttagg agggggaggt      300

cactttataa gggtctgggg gggtcagaac ccagagtcat ccagctggag ccctgagtgg      360

ctgagctcag gccttcgcag cattcttggg tgggagcagc cacgggtcag ccacaagggc      420

cacagcctct agaggatccg gtactcgagg aactgaaaaa ccagaaagtt aactggtaag      480

tttagtcttt ttgtctttta tttcaggtcc cggatccggt ggtggtgcaa atcaaagaac      540

tgctcctcag tggatgttgc ctttacttct aggcctgtac ggaagtgtta ctccgccacc      600

atgggaccga agaaaaagcg caaggtcgaa gcgtccatga aaaggaacta cattctgggg      660

ctggacatcg ggattacaag cgtggggtat gggattattg actatgaaac aagggacgtg      720

atcgacgcag gcgtcagact gttcaaggag gccaacgtgg aaaacaatga gggacggaga      780

agcaagaggg gagccaggcg cctgaaacga cggagaaggc acagaatcca gagggtgaag      840

aaactgctgt tcgattacaa cctgctgacc gaccattctg agctgagtgg aattaatcct      900

tatgaagcca gggtgaaagg cctgagtcag aagctgtcag aggaagagtt ttccgcagct      960

ctgctgcacc tggctaagcg ccgaggagtg cataacgtca atgaggtgga agaggacacc     1020

ggcaacgagc tgtctacaaa ggaacagatc tcacgcaata gcaaagctct ggaagagaag     1080

tatgtcgcag agctgcagct ggaacggctg aagaaagatg gcgaggtgag agggtcaatt     1140

aataggttca agacaagcga ctacgtcaaa gaagccaagc agctgctgaa agtgcagaag     1200

gcttaccacc agctggatca gagcttcatc gatacttata tcgacctgct ggagactcgg     1260

agaacctact atgagggacc aggagaaggg agccccttcg gatggaaaga catcaaggaa     1320

tggtacgaga tgctgatggg acattgcacc tattttccag aagagctgag aagcgtcaag     1380

tacgcttata acgcagatct gtacaacgcc ctgaatgacc tgaacaacct ggtcatcacc     1440

agggatgaaa acgagaaact ggaatactat gagaagttcc agatcatcga aaacgtgttt     1500

aagcagaaga aaaagcctac actgaaacag attgctaagg agatcctggt caacgaagag     1560

gacatcaagg gctaccgggt gacaagcact ggaaaaccag agttcaccaa tctgaaagtg     1620

tatcacgata ttaaggacat cacagcacgg aaagaaatca ttgagaacgc cgaactgctg     1680

gatcagattg ctaagatcct gactatctac cagagctccg aggacatcca ggaagagctg     1740

actaacctga acagcgagct gacccaggaa gagatcgaac agattagtaa tctgaagggg     1800

tacaccggaa cacacaacct gtccctgaaa gctatcaatc tgattctgga tgagctgtgg     1860

catacaaacg acaatcagat tgcaatcttt aaccggctga agctggtccc aaaaaaggtg     1920

gacctgagtc agcagaaaga gatcccaacc acactggtgg acgatttcat tctgtcaccc     1980

gtggtcaagc ggagcttcat ccagagcatc aaagtgatca acgccatcat caagaagtac     2040

ggcctgccca atgatatcat tatcgagctg gctagggaga agaacagcaa ggacgcacag     2100

aagatgatca atgagatgca gaaacgaaac cggcagacca atgaacgcat tgaagagatt     2160

atccgaacta ccgggaaaga gaacgcaaag tacctgattg aaaaaatcaa gctgcacgat     2220

atgcaggagg gaaagtgtct gtattctctg gaggccatcc ccctggagga cctgctgaac     2280

aatccattca actacgaggt cgatcatatt atccccagaa gcgtgtcctt cgacaattcc     2340

tttaacaaca aggtgctggt caagcaggaa gagaactcta aaaagggcaa taggactcct     2400

ttccagtacc tgtctagttc agattccaag atctcttacg aaacctttaa aaagcacatt     2460

ctgaatctgg ccaaaggaaa gggccgcatc agcaagacca aaaaggagta cctgctggaa     2520

gagcgggaca tcaacagatt ctccgtccag aaggatttta ttaaccggaa tctggtggac     2580

acaagatacg ctactcgcgg cctgatgaat ctgctgcgat cctatttccg ggtgaacaat     2640

ctggatgtga aagtcaagtc catcaacggc gggttcacat cttttctgag gcgcaaatgg     2700

aagtttaaaa aggagcgcaa caaagggtac aagcaccatg ccgaagatgc tctgattatc     2760

gcaaatgccg acttcatctt taaggagtgg aaaaagctgg acaaagccaa gaaagtgatg     2820

gagaaccaga tgttcgaaga gaagcaggcc gaatctatgc ccgaaatcga gacagaacag     2880

gagtacaagg agattttcat cactcctcac cagatcaagc atatcaagga tttcaaggac     2940

tacaagtact ctcaccgggt ggataaaaag cccaacagag agctgatcaa tgacaccctg     3000

tatagtacaa gaaaagacga taaggggaat accctgattg tgaacaatct gaacggactg     3060

tacgacaaag ataatgacaa gctgaaaaag ctgatcaaca aaagtcccga gaagctgctg     3120

atgtaccacc atgatcctca gacatatcag aaactgaagc tgattatgga gcagtacggc     3180

gacgagaaga acccactgta taagtactat gaagagactg ggaactacct gaccaagtat     3240

agcaaaaagg ataatggccc cgtgatcaag aagatcaagt actatgggaa caagctgaat     3300

gcccatctgg acatcacaga cgattaccct aacagtcgca acaaggtggt caagctgtca     3360

ctgaagccat acagattcga tgtctatctg gacaacggcg tgtataaatt tgtgactgtc     3420

aagaatctgg atgtcatcaa aaaggagaac tactatgaag tgaatagcaa gtgctacgaa     3480

gaggctaaaa agctgaaaaa gattagcaac caggcagagt tcatcgcctc cttttacaac     3540

aacgacctga ttaagatcaa tggcgaactg tatagggtca tcggggtgaa caatgatctg     3600

ctgaaccgca ttgaagtgaa tatgattgac atcacttacc gagagtatct ggaaaacatg     3660

aatgataagc gcccccctcg aattatcaaa acaattgcct ctaagactca gagtatcaaa     3720

aagtactcaa ccgacattct gggaaacctg tatgaggtga agagcaaaaa gcaccctcag     3780

attatcaaaa agggcggatc ccccaagaag aagaggaaag tctcgagcta ggctggagcc     3840

tcggtggcca tgcttcttgc cccttgggcc tccccccagc ccctcctccc cttcctgcac     3900

ccgtaccccc gtggtctttg aataaagtct gagtgggcgg cacatgctgg ggagagatct     3960

gcggccgcct agcaataaag gatcgtttat tttcattgga agcgtgtgtt ggttttttga     4020

tcaggcgcga ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     4080

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     4140

tgagcgagcg agcgcgcagc tgcctgcagg                                      4170


<210>  11
<211>  2691
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary replacement vector: 250 bp minimal RHO promoter driving
       codon-optimized RHO cDNA; U6 promoter driving gRNA targeting RHO


<220>
<221>  misc_feature
<222>  (1)..(139)
<223>  ITR

<220>
<221>  misc_feature
<222>  (174)..(437)
<223>  U6 promoter

<220>
<221>  misc_feature
<222>  (439)..(460)
<223>  RHO-7 gRNA targeting domain

<220>
<221>  misc_feature
<222>  (461)..(536)
<223>  Sa gRNA scaffold

<220>
<221>  misc_feature
<222>  (563)..(826)
<223>  U6 promoter

<220>
<221>  misc_feature
<222>  (828)..(849)
<223>  RHO-7 gRNA targeting domain

<220>
<221>  misc_feature
<222>  (850)..(925)
<223>  Sa gRNA scaffold

<220>
<221>  misc_feature
<222>  (947)..(1195)
<223>  minRHO promoter (250bp)

<220>
<221>  misc_feature
<222>  (1196)..(1359)
<223>  SV40 intron

<220>
<221>  misc_feature
<222>  (1369)..(2412)
<223>  Codon Optimized RHO cDNA

<220>
<221>  misc_feature
<222>  (2416)..(2526)
<223>  HBA1 UTR

<220>
<221>  misc_feature
<222>  (2553)..(2691)
<223>  ITR

<400>  11
tgcaggcagc tgcgcgctcg ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg       60

gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaac      120

tccatcacta ggggttcctg cggccgcggt tcctcagatc tgaattcggt accaaggtcg      180

ggcaggaaga gggcctattt cccatgattc cttcatattt gcatatacga tacaaggctg      240

ttagagagat aattagaatt aatttgactg taaacacaaa gatattagta caaaatacgt      300

gacgtagaaa gtaataattt cttgggtagt ttgcagtttt aaaattatgt tttaaaatgg      360

actatcatat gcttaccgta acttgaaagt atttcgattt cttggcttta tatatcttgt      420

ggaaaggacg aaacaccgcc cacacccggc tcataccgcc gttatagtac tctggaaaca      480

gaatctacta taacaaggca aaatgccgtg tttatctcgt caacttgttg gcgagatttt      540

ttcgacttag ttcgatcgaa ggaaggtcgg gcaggaagag ggcctatttc ccatgattcc      600

ttcatatttg catatacgat acaaggctgt tagagagata attagaatta atttgactgt      660

aaacacaaag atattagtac aaaatacgtg acgtagaaag taataatttc ttgggtagtt      720

tgcagtttta aaattatgtt ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta      780

tttcgatttc ttggctttat atatcttgtg gaaaggacga aacaccgccc acacccggct      840

cataccgccg ttatagtact ctggaaacag aatctactat aacaaggcaa aatgccgtgt      900

ttatctcgtc aacttgttgg cgagattttt tggtaccgct agcgctgtca ccttggcccc      960

tcttagaagc caattaggcc ctcagtttct gcagcgggga ttaatatgat tatgaacacc     1020

cccaatctcc cagatgctga ttcagccagg agcttaggag ggggaggtca ctttataagg     1080

gtctgggggg gtcagaaccc agagtcatcc agctggagcc ctgagtggct gagctcaggc     1140

cttcgcagca ttcttgggtg ggagcagcca cgggtcagcc acaagggcca cagcctctag     1200

aggatccggt actcgaggaa ctgaaaaacc agaaagttaa ctggtaagtt tagtcttttt     1260

gtcttttatt tcaggtcccg gatccggtgg tggtgcaaat caaagaactg ctcctcagtg     1320

gatgttgcct ttacttctag gcctgtacgg aagtgttact ccgccaccat gaatggcaca     1380

gagggcccta acttctacgt gccctttagc aatgccacag gcgtcgtgcg gagccctttt     1440

gagtaccctc agtactatct ggccgagcct tggcagttta gcatgctggc cgcctacatg     1500

ttcctgctga tcgtgctggg cttccccatc aactttctga ccctgtacgt gaccgtgcag     1560

cacaagaagc tgcggacccc tctgaactac atcctgctga atctggccgt ggccgacctg     1620

tttatggtgc tcggcggctt taccagcaca ctgtacacaa gcctgcacgg ctacttcgtg     1680

tttggcccca ccggctgcaa tctggaaggc ttttttgcca cactcggcgg cgaaattgct     1740

ctgtggtcac tggtggtgct ggccatcgag agatacgtgg tcgtgtgcaa gcccatgagc     1800

aacttcagat tcggcgagaa ccacgccatc atgggcgtcg cctttacatg ggttatggcc     1860

ctggcttgtg cagctcctcc tcttgccggc tggtccagat atattcctga gggcctgcag     1920

tgcagctgcg gcatcgatta ctacaccctg aagcctgaag tgaacaacga gagcttcgtg     1980

atctacatgt ttgtggtgca cttcacgatc cccatgatca tcatattctt ttgctacggc     2040

cagctggtgt tcaccgtgaa agaagccgct gctcagcagc aagagagcgc cacaacacag     2100

aaagccgaga aagaagtgac ccggatggtc attatcatgg ttatcgcctt tctgatctgt     2160

tgggtgccct acgccagcgt ggccttctac atctttaccc accaaggcag caacttcggc     2220

cccatcttta tgacaatccc cgccttcttt gccaagagcg ccgccatcta caaccccgtg     2280

atctatatca tgatgaacaa gcagttccgc aactgcatgc tgaccaccat ctgctgcgga     2340

aagaaccctc tgggagatga tgaggccagc gccaccgtgt ctaagaccga aacatctcag     2400

gtggcccctg catgagctgg agcctcggtg gccatgcttc ttgccccttg ggcctccccc     2460

cagcccctcc tccccttcct gcacccgtac ccccgtggtc tttgaataaa gtctgagtgg     2520

gcggcacatg ctggggagag atctgcggcc gcaggaaccc ctagtgatgg agttggccac     2580

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     2640

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agctgcctgc a              2691


<210>  12
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA scaffold sequence

<400>  12
gttatagtac tctggaaaca gaatctacta taacaaggca aaatgccgtg tttatctcgt       60

caacttgttg gcgaga                                                       76


<210>  13
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized RHO-encoding sequence 1 (Codon 1)

<400>  13
atgaacggca ccgagggccc caacttctac gtccccttca gcaacgccac cggcgtcgtc       60

cgcagcccct tcgagtaccc ccagtactac ctggccgagc cctggcagtt cagcatgctg      120

gccgcctaca tgttcctgct gatcgtcctg ggcttcccca tcaacttcct gaccctgtac      180

gtcaccgtcc agcacaagaa gctgcgcacc cccctgaact acatcctgct gaacctggcc      240

gtcgccgacc tgttcatggt cctgggcggc ttcaccagca ccctgtacac cagcctgcac      300

ggctacttcg tcttcggccc caccggctgc aacctggagg gcttcttcgc caccctgggc      360

ggcgagatcg ccctgtggag cctggtcgtc ctggccatcg agcgctacgt cgtcgtctgc      420

aagcccatga gcaacttccg cttcggcgag aaccacgcca tcatgggcgt cgccttcacc      480

tgggtcatgg ccctggcctg cgccgccccc cccctggccg gctggagccg ctacatcccc      540

gagggcctgc agtgcagctg cggcatcgac tactacaccc tgaagcccga ggtcaacaac      600

gagagcttcg tcatctacat gttcgtcgtc cacttcacca tccccatgat catcatcttc      660

ttctgctacg gccagctggt cttcaccgtc aaggaggccg ccgcccagca gcaggagagc      720

gccaccaccc agaaggccga gaaggaggtc acccgcatgg tcatcatcat ggtcatcgcc      780

ttcctgatct gctgggtccc ctacgccagc gtcgccttct acatcttcac ccaccagggc      840

agcaacttcg gccccatctt catgaccatc cccgccttct tcgccaagag cgccgccatc      900

tacaaccccg tcatctacat catgatgaac aagcagttcc gcaactgcat gctgaccacc      960

atctgctgcg gcaagaaccc cctgggcgac gacgaggcca gcgccaccgt cagcaagacc     1020

gagaccagcc aggtcgcccc cgcctaa                                         1047


<210>  14
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized RHO-encoding sequence 2 (Codon 2)

<400>  14
atgaacggca ccgagggccc caacttctac gtgcccttct ccaacgccac cggcgtggtg       60

cgctccccct tcgagtaccc ccagtactac ctggccgagc cctggcagtt ctccatgctg      120

gccgcctaca tgttcctgct gatcgtgctg ggcttcccca tcaacttcct gaccctgtac      180

gtgaccgtgc agcacaagaa gctgcgcacc cccctgaact acatcctgct gaacctggcc      240

gtggccgacc tgttcatggt gctgggcggc ttcacctcca ccctgtacac ctccctgcac      300

ggctacttcg tgttcggccc caccggctgc aacctggagg gcttcttcgc caccctgggc      360

ggcgagatcg ccctgtggtc cctggtggtg ctggccatcg agcgctacgt ggtggtgtgc      420

aagcccatgt ccaacttccg cttcggcgag aaccacgcca tcatgggcgt ggccttcacc      480

tgggtgatgg ccctggcctg cgccgccccc cccctggccg gctggtcccg ctacatcccc      540

gagggcctgc agtgctcctg cggcatcgac tactacaccc tgaagcccga ggtgaacaac      600

gagtccttcg tgatctacat gttcgtggtg cacttcacca tccccatgat catcatcttc      660

ttctgctacg gccagctggt gttcaccgtg aaggaggccg ccgcccagca gcaggagtcc      720

gccaccaccc agaaggccga gaaggaggtg acccgcatgg tgatcatcat ggtgatcgcc      780

ttcctgatct gctgggtgcc ctacgcctcc gtggccttct acatcttcac ccaccagggc      840

tccaacttcg gccccatctt catgaccatc cccgccttct tcgccaagtc cgccgccatc      900

tacaaccccg tgatctacat catgatgaac aagcagttcc gcaactgcat gctgaccacc      960

atctgctgcg gcaagaaccc cctgggcgac gacgaggcct ccgccaccgt gtccaagacc     1020

gagacctccc aggtggcccc cgcctaa                                         1047


<210>  15
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized RHO-encoding sequence 3 (Codon 3)

<400>  15
atgaacggca ccgagggccc caacttctac gtccccttca gcaacgccac cggcgtcgtc       60

cgcagcccct tcgagtaccc ccagtactac ctggccgagc cctggcagtt ctctatgctg      120

gccgcctaca tgttcctgct gatcgtcctg ggcttcccta tcaacttcct caccctctac      180

gtcaccgtcc agcacaagaa gctccgcacc cctctcaact acatcctcct taaccttgcc      240

gtcgccgacc ttttcatggt ccttggcggc ttcacctcta ctctttacac ttctttgcac      300

gggtacttcg tgttcggtcc tactggttgc aacttggagg gtttcttcgc cactttgggt      360

ggtgagatcg ccttgtggtc gttggtggtg ttagctatcg agcgatacgt ggtggtgtgc      420

aagcctatgt cgaacttccg gttcggtgag aatcatgcta tcatgggagt ggcttttact      480

tgggtgatgg ctttagcttg cgctgctcct ccgttagctg gatggtcgcg ttatatcccg      540

gagggattac agtgctcatg cggaatcgac tattatactc taaagccgga agttaataat      600

gaatcatttg ttatttatat gtttgttgtt cattttacaa ttccgatgat tattattttt      660

ttttgttatg gacagctagt ttttacagtt aaggaagcag cagcacagca acaagaatca      720

gcaacaacac aaaaggcaga aaaagaagtt acaaggatgg ttattattat ggtaattgca      780

tttctaatat gttgggtacc gtatgcatcc gtagcatttt atatatttac acatcaaggg      840

tccaattttg ggccaatatt tatgacgata ccagcgtttt ttgcgaaatc cgcggcgata      900

tataatccag taatatatat aatgatgaat aaacaattta gaaattgtat gctaacgacg      960

atatgttgtg ggaaaaatcc actaggggat gatgaagcga gtgcgacggt aagtaaaacg     1020

gaaacgagtc aagtagcgcc agcgtaa                                         1047


<210>  16
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized RHO-encoding sequence 4 (Codon 4)

<400>  16
atgaacggca ccgagggtcc caatttctac gtcccatttt ccaacgccac gggggtggta       60

cgcagccctt tcgaatatcc gcagtactat ctggctgagc cctggcagtt ttctatgctc      120

gcagcgtaca tgttcttgct aatcgttctg ggatttccaa ttaatttcct cacattgtat      180

gtcaccgtgc agcacaagaa gctacggacg cctctgaact acatcctctt gaatctagcc      240

gtcgctgacc tgtttatggt tctcggcggt ttcacatcga ccttgtatac gtcactacat      300

gggtactttg tcttcggacc gacaggctgc aacctggaag gttttttcgc aaccctcggg      360

ggagagattg cgttgtggtc cctagtggta ctggccatcg aaaggtatgt tgtcgtgtgt      420

aagcccatga gcaattttcg cttcggcgag aaccacgcta ttatgggtgt agcatttacg      480

tgggttatgg cgctcgcctg cgctgcacca cctttggcgg ggtggtctcg gtacatcccg      540

gaaggactac agtgttcgtg cggcattgat tattacacac tgaagcccga ggtcaataac      600

gaatcattcg tgatctatat gtttgtagtt catttcacca ttccaatgat cattatcttt      660

ttctgttacg gtcagctcgt ctttacggtg aaggaggccg ctgcacagca gcaggaatcc      720

gcgacaaccc agaaggccga gaaggaagta acgaggatgg ttattatcat ggtcattgct      780

ttcttgatct gctgggtgcc ttatgcaagc gtagcgtttt acattttcac acaccagggg      840

tctaattttg gaccgatctt catgaccatt cccgcctttt tcgctaagtc ggcagcgatc      900

tataacccag ttatttacat catgatgaat aagcagtttc gcaactgtat gctaacgaca      960

atttgctgtg gcaagaatcc tctgggtgac gatgaggcct cagctaccgt ctccaagacg     1020

gaaacaagcc aggtggcacc ggcgtaa                                         1047


<210>  17
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized RHO-encoding sequence 5 (Codon 5)

<400>  17
atgaatggga ctgaaggacc taatttctat gtgccattta gcaatgctac tggcgttgtc       60

agaagcccct tcgaatatcc acaatactat ctggccgaac cttggcagtt cagcatgctc      120

gctgcctata tgtttctgct gattgtgctg ggctttccca taaatttcct caccctgtat      180

gttactgttc aacacaaaaa gctgcggacg cctctgaact acatactgct gaacctggcc      240

gtcgccgacc tgtttatggt cctgggaggc tttacaagca ctctgtatac aagcctgcac      300

ggctacttcg tgttcggccc cacaggctgc aacctcgaag gcttctttgc caccctcgga      360

ggagagattg ccctgtggag cctggtggtg ctggccatcg aaaggtatgt ggtggtgtgt      420

aaacccatgt ccaattttcg gttcggcgag aaccacgcta ttatgggagt ggctttcact      480

tgggtgatgg ccctggcctg cgccgcccca ccactggccg ggtggagccg gtacatccca      540

gaggggctgc aatgtagctg cggaatcgac tattataccc tgaaaccaga ggtgaacaac      600

gagagctttg tgatttatat gtttgtggtg cattttacaa ttcctatgat tatcattttc      660

ttctgttacg ggcaactggt gtttaccgtg aaggaagccg ccgctcaaca gcaggagagc      720

gccacaaccc aaaaggccga gaaggaggtg accagaatgg tgattattat ggtgatcgct      780

tttctgattt gctgggtgcc atacgctagc gtcgctttct atattttcac tcaccagggg      840

agcaacttcg gccccatttt catgacaatc cctgcctttt ttgctaaaag cgccgccatc      900

tataacccag tgatctacat catgatgaac aaacagttta ggaactgtat gctcacaaca      960

atctgctgtg gaaagaaccc cctcggcgat gacgaagcca gcgccaccgt cagcaagaca     1020

gaaacaagcc aggtggcccc tgcctaa                                         1047


<210>  18
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized RHO-encoding sequence 6 (Codon 6)

<400>  18
atgaatggca cagagggccc taacttctac gtgcccttta gcaatgccac aggcgtcgtg       60

cggagccctt ttgagtaccc tcagtactat ctggccgagc cttggcagtt tagcatgctg      120

gccgcctaca tgttcctgct gatcgtgctg ggcttcccca tcaactttct gaccctgtac      180

gtgaccgtgc agcacaagaa gctgcggacc cctctgaact acatcctgct gaatctggcc      240

gtggccgacc tgtttatggt gctcggcggc tttaccagca cactgtacac aagcctgcac      300

ggctacttcg tgtttggccc caccggctgc aatctggaag gcttttttgc cacactcggc      360

ggcgaaattg ctctgtggtc actggtggtg ctggccatcg agagatacgt ggtcgtgtgc      420

aagcccatga gcaacttcag attcggcgag aaccacgcca tcatgggcgt cgcctttaca      480

tgggttatgg ccctggcttg tgcagctcct cctcttgccg gctggtccag atatattcct      540

gagggcctgc agtgcagctg cggcatcgat tactacaccc tgaagcctga agtgaacaac      600

gagagcttcg tgatctacat gtttgtggtg cacttcacga tccccatgat catcatattc      660

ttttgctacg gccagctggt gttcaccgtg aaagaagccg ctgctcagca gcaagagagc      720

gccacaacac agaaagccga gaaagaagtg acccggatgg tcattatcat ggttatcgcc      780

tttctgatct gttgggtgcc ctacgccagc gtggccttct acatctttac ccaccaaggc      840

agcaacttcg gccccatctt tatgacaatc cccgccttct ttgccaagag cgccgccatc      900

tacaaccccg tgatctatat catgatgaac aagcagttcc gcaactgcat gctgaccacc      960

atctgctgcg gaaagaaccc tctgggagat gatgaggcca gcgccaccgt gtctaagacc     1020

gaaacatctc aggtggcccc tgcatga                                         1047


<210>  19

<400>  19
000

<210>  20

<400>  20
000

<210>  21

<400>  21
000

<210>  22

<400>  22
000

<210>  23

<400>  23
000

<210>  24

<400>  24
000

<210>  25

<400>  25
000

<210>  26

<400>  26
000

<210>  27

<400>  27
000

<210>  28

<400>  28
000

<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33

<400>  33
000

<210>  34

<400>  34
000

<210>  35

<400>  35
000

<210>  36

<400>  36
000

<210>  37

<400>  37
000

<210>  38
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBA1 3'UTR

<400>  38
gctggagcct cggtggccat gcttcttgcc ccttgggcct ccccccagcc cctcctcccc       60

ttcctgcacc cgtacccccg tggtctttga ataaagtctg agtgggcggc a               111


<210>  39
<211>  101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  short HBA1 3'UTR

<400>  39
gctggagcct cggtggccat gcttcttgcc ccttgggcct ccccccagcc cctcctcccc       60

ttcctgcacc cgtacccccg tggtctttga ataaagtctg a                          101


<210>  40
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TH 3'UTR

<400>  40
gtgcacggcg tccctgaggg cccttcccaa cctcccctgg tcctgcactg tcccggagct       60

caggccctgg tgaggggctg ggtcccgggt gccccccatg ccctccctgc tgccaggctc      120

ccactgcccc tgcacctgct tctcagcgca acagctgtgt gtgcccgtgg tgaggttgtg      180

ctgcctgtgg tgaggtcctg tcctggctcc cagggtcctg ggggctgctg cactgccctc      240

cgcccttccc tgacactgtc tgctgcccca atcaccgtca caataaaaga aactgtggtc      300

tcta                                                                   304


<210>  41
<211>  1406
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL1A1 3'UTR

<400>  41
actccctcca tcccaacctg gctccctccc acccaaccaa ctttcccccc aacccggaaa       60

cagacaagca acccaaactg aaccccctca aaagccaaaa aatgggagac aatttcacat      120

ggactttgga aaatattttt ttcctttgca ttcatctctc aaacttagtt tttatctttg      180

accaaccgaa catgaccaaa aaccaaaagt gcattcaacc ttaccaaaaa aaaaaaaaaa      240

aaaagaataa ataaataact ttttaaaaaa ggaagcttgg tccacttgct tgaagaccca      300

tgcgggggta agtccctttc tgcccgttgg gcttatgaaa ccccaatgct gccctttctg      360

ctcctttctc cacacccccc ttggggcctc ccctccactc cttcccaaat ctgtctcccc      420

agaagacaca ggaaacaatg tattgtctgc ccagcaatca aaggcaatgc tcaaacaccc      480

aagtggcccc caccctcagc ccgctcctgc ccgcccagca cccccaggcc ctgggggacc      540

tggggttctc agactgccaa agaagccttg ccatctggcg ctcccatggc tcttgcaaca      600

tctccccttc gtttttgagg gggtcatgcc gggggagcca ccagcccctc actgggttcg      660

gaggagagtc aggaagggcc acgacaaagc agaaacatcg gatttgggga acgcgtgtca      720

atcccttgtg ccgcagggct gggcgggaga gactgttctg ttccttgtgt aactgtgttg      780

ctgaaagact acctcgttct tgtcttgatg tgtcaccggg gcaactgcct gggggcgggg      840

atgggggcag ggtggaagcg gctccccatt ttataccaaa ggtgctacat ctatgtgatg      900

ggtggggtgg ggagggaatc actggtgcta tagaaattga gatgcccccc caggccagca      960

aatgttcctt tttgttcaaa gtctattttt attccttgat atttttcttt tttttttttt     1020

ttttttgtgg atggggactt gtgaattttt ctaaaggtgc tatttaacat gggaggagag     1080

cgtgtgcggc tccagcccag cccgctgctc actttccacc ctctctccac ctgcctctgg     1140

cttctcaggc ctctgctctc cgacctctct cctctgaaac cctcctccac agctgcagcc     1200

catcctcccg gctccctcct agtctgtcct gcgtcctctg tccccgggtt tcagagacaa     1260

cttcccaaag cacaaagcag tttttccccc taggggtggg aggaagcaaa agactctgta     1320

cctattttgt atgtgtataa taatttgaga tgtttttaat tattttgatt gctggaataa     1380

agcatgtgga aatgacccaa acataa                                          1406


<210>  42
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALOX15 3'UTR

<400>  42
gcgtcgccac cctttggtta tttcagcccc catcacccaa gccacaagct gaccccttcg       60

tggttatagc cctgccctcc caagtcccac cctcttccca tgtcccaccc tccctagagg      120

ggcacctttt catggtctct gcacccagtg aacacatttt actctagagg catcacctgg      180

gaccttactc ctctttcctt ccttcctcct ttcctatctt ccttcctctc tctcttcctc      240

tttcttcatt cagatctata tggcaaatag ccacaattat ataaatcatt tcaagactag      300

aataggggga tataatacat attactccac accttttatg aatcaaatat gatttttttg      360

ttgttgttaa gacagagtct cactttgaca cccaggctgg agtgcagtgg tgccatcacc      420

acggctcact gcagcctcag cgtcctgggc tcaaatgatc ctcccacctc agcctcctga      480

gtagctggga ctacaggctc atgccatcat gcccagctaa tattttttta ttttcgtgga      540

gacggggcct cactatgttg cctaggctgg aaataggatt ttgaacccaa attgagttta      600

acaataataa aaagttgttt tacgctaaag atggaaaaga actaggactg aactatttta      660

aataaaatat tggcaaaaga a                                                681


<210>  43
<211>  516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human rhodopsin promoter

<400>  43
ccacgtcaga atcaaaccct caccttaacc tcattagcgt tgggcataat caccaggcca       60

agcgccttaa actacgagag gccccatccc acccgccctg ccttagccct gccacgtgtg      120

ccaaacgctg ttagacccaa caccacccag gccaggtagg gggctggagc ccaggtgggc      180

atttgagtca ccaaccccca ggcagtctcc cttttcctgg atcctgagta cctctcctcc      240

ctgacctcag gcttcctcct agtgtcacct tggcccctct tagaagccaa ttaggccctc      300

agtttctgca gcggggatta atatgattat gaacaccccc aatctcccag atgctgattc      360

agccaggagc ttaggagggg gaggtcactt tataagggtc tgggggggtc agaacccaga      420

gtcatccagc tggagccctg agtggctgag ctcaggcctt cgcagcattc ttgggtggga      480

gcagccacgg gtcagccaca agggccacca ccatgg                                516


<210>  44
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Minimal Human rhodopsin promoter

<400>  44
gtcaccttgg cccctcttag aagccaatta ggccctcagt ttctgcagcg gggattaata       60

tgattatgaa cacccccaat ctcccagatg ctgattcagc caggagctta ggagggggag      120

gtcactttat aagggtctgg gggggtcaga acccagagtc atccagctgg agccctgagt      180

ggctgagctc aggccttcgc agcattcttg ggtgggagca gccacgggtc agccacaagg      240

gccacagcc                                                              249


<210>  45
<211>  617
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter

<400>  45
cattgattat tgactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca       60

tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac      120

gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact      180

ttccattgac gtcaatgggt ggactattta cggtaaactg cccacttggc agtacatcaa      240

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      300

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      360

gtcatcgcta ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg      420

tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg      480

caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg      540

ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctggtttagt gaaccgtcag      600

atccgctaga gatccgc                                                     617


<210>  46
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EFS promoter

<400>  46
tcgagtggct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag       60

ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg ggtaaactgg      120

gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata      180

agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacaggtg      240

tcgtgaccgc gg                                                          252


<210>  47
<211>  292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human GRK1 (rhodopsin kinase) promoter

<400>  47
gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg cggccccttg       60

gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg gattgtcttt      120

ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg atttcgcctg      180

gtgctgtgtc agccccggtc tcccaggggc ttcccagtgg tccccaggaa ccctcgacag      240

ggcccggtct ctctcgtcca gcaagggcag ggacgggcca caggccaagg gc              292


<210>  48
<211>  113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CRX (cone rod homeobox transcription factor) promoter

<400>  48
gcctgtagcc ttaatctctc ctagcagggg gtttggggga gggaggagga gaaagaaagg       60

gccccttatg gctgagacac aatgacccag ccacaaggag ggattaccgg gcg             113


<210>  49
<211>  281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NRL (neural retina leucine zipper transcription factor 
       enhance upstream of the human TK terminal promoter)

<400>  49
aggtaggaag tggcctttaa ctccatagac cctatttaaa cagcttcgga caggtttaaa       60

catctccttg gataattcct agtatccctg ttcccactcc tactcaggga tgatagctct      120

aagaggtgtt aggggattag gctgaaaatg taggtcaccc ctcagccatc tgggaactag      180

aatgagtgag agaggagaga ggggcagaga cacacacatt cgcatattaa ggtgacgcgt      240

gtggcctcga acaccgagcg accctgcagc gacccgctta a                          281


<210>  50
<211>  235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human RCVRN (recoverin) promoter

<400>  50
attttaatct cactagggtt ctgggagcac ccccccccac cgctcccgcc ctccacaaag       60

ctcctgggcc cctcctccct tcaaggattg cgaagagctg gtcgcaaatc ctcctaagcc      120

accagcatct cggtcttcag ctcacaccag ccttgagccc agcctgcggc caggggacca      180

cgcacgtccc acccacccag cgactcccca gccgctgccc actcttcctc actca           235


<210>  51
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3X Flag tag

<400>  51

Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys 
            20          


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag (single)

<400>  52

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA tag

<400>  53

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  54

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIS tag

<400>  55

His His His His His His 
1               5       


<210>  56
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mini polyA

<400>  56
tagcaataaa ggatcgttta ttttcattgg aagcgtgtgt tggttttttg atcaggcgcg       60


<210>  57
<211>  228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bGH polyA

<400>  57
gctgcaggat gaccggtcat catcaccatc accattgagt ttaaacccgc tgatcagcct       60

cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga      120

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt      180

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggaca                   228


<210>  58
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 polyA

<400>  58
atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa       60

taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg      120

ggaggttttt taaa                                                        134


<210>  59
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV1 Left ITR

<400>  59
ttgcccactc cctctctgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcag agagggagtg      120

ggcaactcca tcactagggg taa                                              143


<210>  60
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 Left ITR

<400>  60
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  61
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV3B Left ITR

<400>  61
tggccactcc ctctatgcgc actcgctcgc tcggtggggc ctggcgacca aaggtcgcca       60

gacggacgtg ctttgcacgt ccggccccac cgagcgagcg agtgcgcata gagggagtgg      120

ccaactccat cactagaggt at                                               142


<210>  62
<211>  146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV4 Left ITR

<400>  62
ttggccactc cctctatgcg cgctcgctca ctcactcggc cctggagacc aaaggtctcc       60

agactgccgg cctctggccg gcagggccga gtgagtgagc gagcgcgcat agagggagtg      120

gccaactcca tcatctaggt ttgccc                                           146


<210>  63
<211>  155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV5 Left ITR

<400>  63
ctctcccccc tgtcgcgttc gctcgctcgc tggctcgttt gggggggtgg cagctcaaag       60

agctgccaga cgacggccct ctggccgtcg cccccccaaa cgagccagcg agcgagcgaa      120

cgcgacaggg gggagagtgc cacactctca agcaa                                 155


<210>  64
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV6 Left ITR

<400>  64
atacccctag tgatggagtt gcccactccc tctatgcgcg ctcgctcgct cggtggggcc       60

ggcagagcag agctctgccg tctgcggacc tttggtccgc aggccccacc gagcgagcga      120

gcgcgcatag agggagtggg caa                                              143


<210>  65
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV7 Left ITR

<400>  65
ttggccactc cctctatgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcat agagggagtg      120

gccaactcca tcactagggg taccg                                            145


<210>  66
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV8 Left ITR

<400>  66
cagagaggga gtggccaact ccatcactag gggtagcgcg aagcgcctcc cacgctgccg       60

cgtcagcgct gacgtaaatt acgtcatagg ggagtggtcc tgtattagct gtcacgtgag      120

tgcttttgcg gcattttgcg acacc                                            145


<210>  67
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 Left ITR

<400>  67
cagagaggga gtggccaact ccatcactag gggtaatcgc gaagcgcctc ccacgctgcc       60

gcgtcagcgc tgacgtagat tacgtcatag gggagtggtc ctgtattagc tgtcacgtga      120

gtgcttttgc gacattttgc gacac                                            145


<210>  68
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV1 Right ITR

<400>  68
ttacccctag tgatggagtt gcccactccc tctctgcgcg ctcgctcgct cggtggggcc       60

ggcagagcag agctctgccg tctgcggacc tttggtccgc aggccccacc gagcgagcga      120

gcgcgcagag agggagtggg caa                                              143


<210>  69
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 Right ITR

<400>  69
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  70
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV3B Right ITR

<400>  70
atacctctag tgatggagtt ggccactccc tctatgcgca ctcgctcgct cggtggggcc       60

ggacgtgcaa agcacgtccg tctggcgacc tttggtcgcc aggccccacc gagcgagcga      120

gtgcgcatag agggagtggc ca                                               142


<210>  71
<211>  146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV4 Right ITR

<400>  71
gggcaaacct agatgatgga gttggccact ccctctatgc gcgctcgctc actcactcgg       60

ccctgccggc cagaggccgg cagtctggag acctttggtc tccagggccg agtgagtgag      120

cgagcgcgca tagagggagt ggccaa                                           146


<210>  72
<211>  155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV5 Right ITR

<400>  72
ttgcttgaga gtgtggcact ctcccccctg tcgcgttcgc tcgctcgctg gctcgtttgg       60

gggggcgacg gccagagggc cgtcgtctgg cagctctttg agctgccacc cccccaaacg      120

agccagcgag cgagcgaacg cgacaggggg gagag                                 155


<210>  73
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV6 Right ITR

<400>  73
ttgcccactc cctctatgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcat agagggagtg      120

ggcaactcca tcactagggg tat                                              143


<210>  74
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV7 Right ITR

<400>  74
cggtacccct agtgatggag ttggccactc cctctatgcg cgctcgctcg ctcggtgggg       60

ccggcagagc agagctctgc cgtctgcgga cctttggtcc gcaggcccca ccgagcgagc      120

gagcgcgcat agagggagtg gccaa                                            145


<210>  75
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV8 Right ITR

<400>  75
ggtgtcgcaa aatgccgcaa aagcactcac gtgacagcta atacaggacc actcccctat       60

gacgtaattt acgtcagcgc tgacgcggca gcgtgggagg cgcttcgcgc tacccctagt      120

gatggagttg gccactccct ctctg                                            145


<210>  76
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 Right ITR

<400>  76
gtgtcgcaaa atgtcgcaaa agcactcacg tgacagctaa tacaggacca ctcccctatg       60

acgtaatcta cgtcagcgct gacgcggcag cgtgggaggc gcttcgcgat tacccctagt      120

gatggagttg gccactccct ctctg                                            145


<210>  77
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer

<400>  77
cagatctgaa ttcggtacc                                                    19


<210>  78
<211>  264
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U6 Promoter

<400>  78
aaggtcgggc aggaagaggg cctatttccc atgattcctt catatttgca tatacgatac       60

aaggctgtta gagagataat tagaattaat ttgactgtaa acacaaagat attagtacaa      120

aatacgtgac gtagaaagta ataatttctt gggtagtttg cagttttaaa attatgtttt      180

aaaatggact atcatatgct taccgtaact tgaaagtatt tcgatttctt ggctttatat      240

atcttgtgga aaggacgaaa cacc                                             264


<210>  79
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA scaffold domain

<400>  79
gttttagtac tctggaaaca gaatctacta aaacaaggca aaatgccgtg tttatctcgt       60

caacttgttg gcgagatttt tt                                                82


<210>  80
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer

<400>  80
ggtaccgcta gcgcttaagt cgcgatgtac gggccagata tacgcgttga                  50


<210>  81
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N-ter NLS nucleotide sequence

<400>  81
ccgaagaaaa agcgcaaggt cgaagcgtcc                                        30


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-ter NLS amino acid sequence

<400>  82

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-ter NLS sequence

<400>  83
cccaagaaga agaggaaagt c                                                 21


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-ter NLS amino acid sequence

<400>  84

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  85
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer

<400>  85
tccaagcttc gcaggaaaga acatgtgagc aaaaggccag caaaaggcgt taactctaga       60

tttaaatgca tgctggggag agatct                                            86


<210>  86
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3X FLAG nucleotide sequence

<400>  86
gactacaaag accatgacgg tgattataaa gatcatgaca tcgattacaa ggatgacgat       60

gacaag                                                                  66


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer

<400>  87
cgacttagtt cgatcgaagg                                                   20


<210>  88
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Unimolecular S. aureus gRNA


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  targeting domain (between 16 and 24 bases in length)

<220>
<221>  misc_feature
<222>  (17)..(24)
<223>  a, c, t, g, unknown, absent or other

<220>
<221>  misc_feature
<222>  (25)..(38)
<223>  crRNA

<220>
<221>  misc_feature
<222>  (39)..(42)
<223>  GAAA linker

<220>
<221>  misc_feature
<222>  (43)..(106)
<223>  tracrRNA

<400>  88
nnnnnnnnnn nnnnnnnnnn nnnngtttta gtactctgga aacagaatct actaaaacaa       60

ggcaaaatgc cgtgtttatc tcgtcaactt gttggcgaga tttttt                     106


<210>  89
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Unimolecular S. aureus gRNA


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  a, c, g, u, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  targeting domain (between 16 and 24 bases in length)

<220>
<221>  misc_feature
<222>  (17)..(24)
<223>  a, c, g, u, unknown, absent or other

<220>
<221>  misc_feature
<222>  (25)..(38)
<223>  crRNA

<220>
<221>  misc_feature
<222>  (39)..(42)
<223>  GAAA linker

<220>
<221>  misc_feature
<222>  (43)..(106)
<223>  tracrRNA

<400>  89
nnnnnnnnnn nnnnnnnnnn nnnnguuuua guacucugga aacagaaucu acuaaaacaa       60

ggcaaaaugc cguguuuauc ucgucaacuu guuggcgaga uuuuuu                     106


<210>  90
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Unimolecular S. aureus gRNA


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  targeting domain (between 16 and 24 bases in length)

<220>
<221>  misc_feature
<222>  (17)..(24)
<223>  a, c, t, g, unknown, absent or other

<220>
<221>  misc_feature
<222>  (25)..(38)
<223>  crRNA

<220>
<221>  misc_feature
<222>  (39)..(42)
<223>  GAAA linker

<220>
<221>  misc_feature
<222>  (43)..(106)
<223>  tracrRNA

<400>  90
nnnnnnnnnn nnnnnnnnnn nnnngttata gtactctgga aacagaatct actataacaa       60

ggcaaaatgc cgtgtttatc tcgtcaactt gttggcgaga tttttt                     106


<210>  91
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Unimolecular S. aureus gRNA


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  targeting domain (between 16 and 24 bases in length)

<220>
<221>  misc_feature
<222>  (17)..(24)
<223>  a, c, u, g, unknown, absent or other

<220>
<221>  misc_feature
<222>  (25)..(38)
<223>  crRNA

<220>
<221>  misc_feature
<222>  (39)..(42)
<223>  GAAA linker

<220>
<221>  misc_feature
<222>  (43)..(106)
<223>  tracrRNA

<400>  91
nnnnnnnnnn nnnnnnnnnn nnnnguuaua guacucugga aacagaaucu acuauaacaa       60

ggcaaaaugc cguguuuauc ucgucaacuu guuggcgaga uuuuuu                     106


<210>  92
<211>  139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV Left ITR

<400>  92
tgcaggcagc tgcgcgctcg ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg       60

gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaac      120

tccatcacta ggggttcct                                                   139


<210>  93
<211>  139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV Right ITR

<400>  93
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgca                                                   139


<210>  94
<211>  164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 intron

<400>  94
tctagaggat ccggtactcg aggaactgaa aaaccagaaa gttaactggt aagtttagtc       60

tttttgtctt ttatttcagg tcccggatcc ggtggtggtg caaatcaaag aactgctcct      120

cagtggatgt tgcctttact tctaggcctg tacggaagtg ttac                       164


<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-1 targeting domain

<400>  100
gucagccaca agggccacag cc                                                22


<210>  101
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-2 targeting domain

<400>  101
ccgaagacga aguauccaug ca                                                22


<210>  102
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-3 targeting domain

<400>  102
aguauccaug cagagaggug ua                                                22


<210>  103
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-4 targeting domain

<400>  103
cuagguugag caggauguag uu                                                22


<210>  104
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-5 targeting domain

<400>  104
cauggcucag ccagguagua cu                                                22


<210>  105
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-6 targeting domain

<400>  105
acgggugugg uacgcagccc cu                                                22


<210>  106
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-7 targeting domain

<400>  106
cccacacccg gcucauaccg cc                                                22


<210>  107
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-8 targeting domain

<400>  107
cccugggcgg uaugagccgg gu                                                22


<210>  108
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-9 targeting domain

<400>  108
ccaucauggg cguugccuuc ac                                                22


<210>  109
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-10 targeting domain

<400>  109
gugccauuac cuggaccagc cg                                                22


<210>  110
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-11 targeting domain

<400>  110
uuaccuggac cagccggcga gu                                                22


<210>  111
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-12 targeting domain

<400>  111
gcauucuugg gugggagcag cc                                                22


<210>  112
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-13 targeting domain

<400>  112
gcucagccac ucagggcucc ag                                                22


<210>  113
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-14 targeting domain

<400>  113
ugacccgugg cugcucccac cc                                                22


<210>  114
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-15 targeting domain

<400>  114
agcucaggcc uucgcagcau uc                                                22


<210>  115
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-16 targeting domain

<400>  115
uagcagaaga augcauccua au                                                22


<210>  116
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-17 targeting domain

<400>  116
acacgcugag gagagcuggg ca                                                22


<210>  117
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-18 targeting domain

<400>  117
gcaaauaacu ucccccauuc cc                                                22


<210>  118
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-19 targeting domain

<400>  118
agacccaggc ugggcacuga gg                                                22


<210>  119
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-20 targeting domain

<400>  119
cuaggucucc uggcugugau cc                                                22


<210>  120
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-21 targeting domain

<400>  120
ccagaaggug ggugugccac uu                                                22


<210>  121
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-22 targeting domain

<400>  121
aacaaggaac ucugccccac au                                                22


<210>  122
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-23 targeting domain

<400>  122
caggauugaa cugggaaccc gg                                                22


<210>  123
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-24 targeting domain

<400>  123
gggcgucaca cagggacggg ug                                                22


<210>  124
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-25 targeting domain

<400>  124
cugugaucca ggaauaucuc ug                                                22


<210>  125
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-26 targeting domain

<400>  125
uugcauuuaa caggaaaaca ga                                                22


<210>  126
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-27 targeting domain

<400>  126
ggagugcacc cuccuuaggc ag                                                22


<210>  127
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-28 targeting domain

<400>  127
caucuguccu gcucaccacc cc                                                22


<210>  128
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-29 targeting domain

<400>  128
gaggggaggc agaggaugcc ag                                                22


<210>  129
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-30 targeting domain

<400>  129
cucagggaau cucuggccau ug                                                22


<210>  130
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-31 targeting domain

<400>  130
ugcacucccc ccuagacagg ga                                                22


<210>  131
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-32 targeting domain

<400>  131
ugcuguuugu gcagggcugg ca                                                22


<210>  132
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-33 targeting domain

<400>  132
acugggacau uccuaacagu ga                                                22


<210>  133
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-34 targeting domain

<400>  133
aucagggggu caggauugaa cu                                                22


<210>  134
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-35 targeting domain

<400>  134
cuccucucug ggggcccaag cu                                                22


<210>  135
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-36 targeting domain

<400>  135
cugcaucuca gcagagauau uc                                                22


<210>  136
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-37 targeting domain

<400>  136
uguuucccuu ggagcagcug ug                                                22


<210>  137
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-38 targeting domain

<400>  137
gcgcucuggg cccauaaggg ac                                                22


<210>  138
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-39 targeting domain

<400>  138
aggauugaac ugggaacccg gu                                                22


<210>  139
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-40 targeting domain

<400>  139
ccuaggagag gcccccacau gu                                                22


<210>  140
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-41 targeting domain

<400>  140
aucacucagu ucuggccaga ag                                                22


<210>  141
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-42 targeting domain

<400>  141
agagcugggc aaagaaauuc ca                                                22


<210>  142
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-43 targeting domain

<400>  142
ccaccccaug aaguuccaua gg                                                22


<210>  143
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-44 targeting domain

<400>  143
ccacccugag cuugggcccc ca                                                22


<210>  144
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-45 targeting domain

<400>  144
cagaggaaga agaaggaaau ga                                                22


<210>  145
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-46 targeting domain

<400>  145
aaacagcagc ccggcuauca cc                                                22


<210>  146
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-47 targeting domain

<400>  146
ggauugaacu gggaacccgg ua                                                22


<210>  147
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-48 targeting domain

<400>  147
ugugugugug uguguuuagc ag                                                22


<210>  148
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-49 targeting domain

<400>  148
ucacacaggg acgggugcag ag                                                22


<210>  149
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-50 targeting domain

<400>  149
gugugugugu guguguguuu ag                                                22


<210>  150
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-51 targeting domain

<400>  150
ugagcuuggg cccccagaga gg                                                22


<210>  151
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-52 targeting domain

<400>  151
aauaucucug cugagaugca gg                                                22


<210>  152
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-53 targeting domain

<400>  152
ggagagggga agagacucau uu                                                22


<210>  153
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-54 targeting domain

<400>  153
agaacugagu gaucugugau ua                                                22


<210>  154
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-55 targeting domain

<400>  154
ccacucuccc uauggaacuu ca                                                22


<210>  155
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-56 targeting domain

<400>  155
auaagggaca cgaaucagau ca                                                22


<210>  156
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-57 targeting domain

<400>  156
uggauuuucc auucuccagu ca                                                22


<210>  157
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-58 targeting domain

<400>  157
gugcaggagc ccgggagcau gg                                                22


<210>  158
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-59 targeting domain

<400>  158
ggguggugag caggacagau gu                                                22


<210>  159
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-60 targeting domain

<400>  159
cagcucuccc ucagugccca gc                                                22


<210>  160
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-61 targeting domain

<400>  160
ccugcugggg cgucacacag gg                                                22


<210>  161
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-62 targeting domain

<400>  161
cacacacaca caaaacuccc ua                                                22


<210>  162
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-63 targeting domain

<400>  162
acuuacgggu gguuguucuc ug                                                22


<210>  163
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-64 targeting domain

<400>  163
cacagggaag acccaaugac ug                                                22


<210>  164
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-65 targeting domain

<400>  164
agcacagacc ccacugccua ag                                                22


<210>  165
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-66 targeting domain

<400>  165
accugaggac aggggcugag ag                                                22


<210>  166
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-67 targeting domain

<400>  166
caacaauggc cagagauucc cu                                                22


<210>  167
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-68 targeting domain

<400>  167
ugcugccucg gucccauucu ca                                                22


<210>  168
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-69 targeting domain

<400>  168
ugcugccugg ccacaucccu aa                                                22


<210>  169
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-70 targeting domain

<400>  169
gccacucucc cuauggaacu uc                                                22


<210>  170
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-71 targeting domain

<400>  170
gagggaggaa ggacugccaa uu                                                22


<210>  171
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-72 targeting domain

<400>  171
gaggguagcu aggaaggcaa cc                                                22


<210>  172
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-73 targeting domain

<400>  172
ggaaggcaac caggaguggg ag                                                22


<210>  173
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-74 targeting domain

<400>  173
gcugagaugc aggaggagac gc                                                22


<210>  174
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-75 targeting domain

<400>  174
aggcuggagg ggcaccugag ga                                                22


<210>  175
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-76 targeting domain

<400>  175
aggaaggcaa ccaggagugg ga                                                22


<210>  176
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-77 targeting domain

<400>  176
ccgggagcau ggaggggucu gg                                                22


<210>  177
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-78 targeting domain

<400>  177
ggauaacaga ucccacuuaa ca                                                22


<210>  178
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-79 targeting domain

<400>  178
aggcagagga ugccagaggg ga                                                22


<210>  179
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-80 targeting domain

<400>  179
gggcccaagc ucaggguggg aa                                                22


<210>  180
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-81 targeting domain

<400>  180
uaacuauaug gccacucucc cu                                                22


<210>  181
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-82 targeting domain

<400>  181
ucccacuuaa cagagaggaa aa                                                22


<210>  182
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-83 targeting domain

<400>  182
gaaugcagag gugguggaaa cc                                                22


<210>  183
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-84 targeting domain

<400>  183
gggagacagg gcaaggcugg ca                                                22


<210>  184
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-85 targeting domain

<400>  184
caccacccca ugaaguucca ua                                                22


<210>  185
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-86 targeting domain

<400>  185
gccauauagu uaaucaacca aa                                                22


<210>  186
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-87 targeting domain

<400>  186
guagcuagga aggcaaccag ga                                                22


<210>  187
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-88 targeting domain

<400>  187
cacauugcuu cauggcuccu ag                                                22


<210>  188
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-89 targeting domain

<400>  188
cugagcuugg gcccccagag ag                                                22


<210>  189
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-90 targeting domain

<400>  189
accgagccca uugcccagca ca                                                22


<210>  190
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-91 targeting domain

<400>  190
cucaaagaag ucaagcgccc ug                                                22


<210>  191
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-92 targeting domain

<400>  191
gcuacccucu cccugucuag gg                                                22


<210>  192
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-93 targeting domain

<400>  192
acccugagcu ugggccccca ga                                                22


<210>  193
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-94 targeting domain

<400>  193
ggcagaggga ccacacgcug ag                                                22


<210>  194
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-95 targeting domain

<400>  194
ucugacucag cacagcugcu cc                                                22


<210>  195
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-96 targeting domain

<400>  195
cucucagcca ccaccgccaa gc                                                22


<210>  196
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-97 targeting domain

<400>  196
agggaugugg ccaggcagca ac                                                22


<210>  197
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-98 targeting domain

<400>  197
caccugagga caggggcuga ga                                                22


<210>  198
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-99 targeting domain

<400>  198
gcccaugaug gcaugguucu cc                                                22


<210>  199
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-100 targeting domain

<400>  199
gaaggggcag agggaccaca cg                                                22


<210>  200
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-101 targeting domain

<400>  200
agcacccucu acaccucucu gc                                                22


<210>  201
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-102 targeting domain

<400>  201
cuuuggauaa cauugacagg ac                                                22


<210>  202
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-103 targeting domain

<400>  202
ggugaagcca ccuaggacca ug                                                22


<210>  203
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-104 targeting domain

<400>  203
uaacauugac aggacaggag aa                                                22


<210>  204
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-105 targeting domain

<400>  204
gggagagggg aagagacuca uu                                                22


<210>  205
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-106 targeting domain

<400>  205
gcugugcuga gucagaccca gg                                                22


<210>  206
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-107 targeting domain

<400>  206
uugaggaggc cuuggggaag ga                                                22


<210>  207
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-108 targeting domain

<400>  207
gcccgggagc auggaggggu cu                                                22


<210>  208
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-109 targeting domain

<400>  208
guaaacuggg acugacccug ca                                                22


<210>  209
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-110 targeting domain

<400>  209
auaacauuga caggacagga ga                                                22


<210>  210
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-111 targeting domain

<400>  210
ggcagggagg cuggaggggc ac                                                22


<210>  211
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-112 targeting domain

<400>  211
gcaaacaugg cccgagauag au                                                22


<210>  212
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-113 targeting domain

<400>  212
ggaccgagcc cauugcccag ca                                                22


<210>  213
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-114 targeting domain

<400>  213
gcucuacguc accguccagc ac                                                22


<210>  214
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-115 targeting domain

<400>  214
agcacagcug cuccaaggga aa                                                22


<210>  215
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-116 targeting domain

<400>  215
cuaaagcaaa aaggaacugc uu                                                22


<210>  216
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-117 targeting domain

<400>  216
gagaggaaaa cugaggcagg ga                                                22


<210>  217
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-118 targeting domain

<400>  217
cauugcaaag cugggugacg gg                                                22


<210>  218
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-119 targeting domain

<400>  218
uugccacccu gggcgguaug ag                                                22


<210>  219
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-120 targeting domain

<400>  219
agcuaggaag gcaaccagga gu                                                22


<210>  220
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-121 targeting domain

<400>  220
ucucuggggg cccaagcuca gg                                                22


<210>  221
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-122 targeting domain

<400>  221
agcacaggga agacccaaug ac                                                22


<210>  222
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-123 targeting domain

<400>  222
guugacugaa uauaugaggg cu                                                22


<210>  223
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-124 targeting domain

<400>  223
uuguaaacug ggacugaccc ug                                                22


<210>  224
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-125 targeting domain

<400>  224
cacacccacc uucuggccag aa                                                22


<210>  225
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-126 targeting domain

<400>  225
ccagaggaag aagaaggaaa ug                                                22


<210>  226
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-127 targeting domain

<400>  226
gagauauucc uggaucacag cc                                                22


<210>  227
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-128 targeting domain

<400>  227
aggggcagag ggaccacacg cu                                                22


<210>  228
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-129 targeting domain

<400>  228
aacuauaugg ccacucuccc ua                                                22


<210>  229
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-130 targeting domain

<400>  229
gcugcuugcg guucucaaca cc                                                22


<210>  230
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-131 targeting domain

<400>  230
caccaugaau gguguuuguu ga                                                22


<210>  231
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-132 targeting domain

<400>  231
gcagccauug caaagcuggg ug                                                22


<210>  232
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-133 targeting domain

<400>  232
ugacucagca cagcugcucc aa                                                22


<210>  233
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-134 targeting domain

<400>  233
cugggaggag ggggaagggg ca                                                22


<210>  234
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-135 targeting domain

<400>  234
gauaacauug acaggacagg ag                                                22


<210>  235
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-136 targeting domain

<400>  235
ccaaacuggg acauuccuaa ca                                                22


<210>  236
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-137 targeting domain

<400>  236
aggaaaacag auggggugcu gc                                                22


<210>  237
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-138 targeting domain

<400>  237
cggacaugug ggggccucuc cu                                                22


<210>  238
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-139 targeting domain

<400>  238
gcaaagaaau uccagggaau gg                                                22


<210>  239
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-140 targeting domain

<400>  239
ccaggagacu uggaacgcgg ca                                                22


<210>  240
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-141 targeting domain

<400>  240
ugguccuugg ugguccuggc ca                                                22


<210>  241
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-142 targeting domain

<400>  241
aauggaaaau ccacuuccca cc                                                22


<210>  242
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-143 targeting domain

<400>  242
gcccgaagac gaaguaucca ug                                                22


<210>  243
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-144 targeting domain

<400>  243
gugcuggacg gugacguaga gc                                                22


<210>  244
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-145 targeting domain

<400>  244
agaaacaugu aggcggccag ca                                                22


<210>  245
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-146 targeting domain

<400>  245
ccgcucgaug gccaggacca cc                                                22


<210>  246
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-147 targeting domain

<400>  246
ucagcacaga ccccacugcc ua                                                22


<210>  247
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-148 targeting domain

<400>  247
gaauaucucu gcugagaugc ag                                                22


<210>  248
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-149 targeting domain

<400>  248
gaguacccac aguacuaccu gg                                                22


<210>  249
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-150 targeting domain

<400>  249
caaccaggag ugggagaggg au                                                22


<210>  250
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-151 targeting domain

<400>  250
uugagaaccg caagcagccg cu                                                22


<210>  251
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-152 targeting domain

<400>  251
gcaagccaga ccccuccucu cu                                                22


<210>  252
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-153 targeting domain

<400>  252
gagagcuggg caaagaaauu cc                                                22


<210>  253
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-154 targeting domain

<400>  253
cgaggcagca gccuggacau gg                                                22


<210>  254
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-155 targeting domain

<400>  254
aggaauaucu cugcugagau gc                                                22


<210>  255
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-156 targeting domain

<400>  255
uucccgagaa gggagaggga gg                                                22


<210>  256
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-157 targeting domain

<400>  256
uccuuccucc cucucccuuc uc                                                22


<210>  257
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-158 targeting domain

<400>  257
uguuuugccc agaggaagaa ga                                                22


<210>  258
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-159 targeting domain

<400>  258
ccggcugguc cagguaaugg ca                                                22


<210>  259
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-160 targeting domain

<400>  259
cagcacaggg aagacccaau ga                                                22


<210>  260
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-161 targeting domain

<400>  260
accaggagug ggagagggau uu                                                22


<210>  261
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-162 targeting domain

<400>  261
gcuggugaag ccaccuagga cc                                                22


<210>  262
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-163 targeting domain

<400>  262
ggcgguauga gccgggugug gg                                                22


<210>  263
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-164 targeting domain

<400>  263
cagccauugc aaagcugggu ga                                                22


<210>  264
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-165 targeting domain

<400>  264
acauugacag gacaggagaa gg                                                22


<210>  265
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-166 targeting domain

<400>  265
ugggucuucc cugugcuggg ca                                                22


<210>  266
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-167 targeting domain

<400>  266
guacguggug guguguaagc cc                                                22


<210>  267
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-168 targeting domain

<400>  267
agcaaauaac uucccccauu cc                                                22


<210>  268
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-169 targeting domain

<400>  268
ggauuugagg aggccuuggg ga                                                22


<210>  269
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-170 targeting domain

<400>  269
cccugagcuu gggcccccag ag                                                22


<210>  270
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-171 targeting domain

<400>  270
cagagauucc cugagaaugg ga                                                22


<210>  271
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-172 targeting domain

<400>  271
gaguuggaag cccgcaucua uc                                                22


<210>  272
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-173 targeting domain

<400>  272
aguccuuccu cccucucccu uc                                                22


<210>  273
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-174 targeting domain

<400>  273
guuauuucau uucccgagaa gg                                                22


<210>  274
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-175 targeting domain

<400>  274
auuucauuuc ccgagaaggg ag                                                22


<210>  275
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-176 targeting domain

<400>  275
gacguagagc gugaggaagu ug                                                22


<210>  276
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-177 targeting domain

<400>  276
cauuucccga gaagggagag gg                                                22


<210>  277
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-178 targeting domain

<400>  277
guagagcgug aggaaguuga ug                                                22


<210>  278
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-179 targeting domain

<400>  278
caggccuucg cagcauucuu gg                                                22


<210>  279
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-180 targeting domain

<400>  279
agguaguacu guggguacuc ga                                                22


<210>  280
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-181 targeting domain

<400>  280
aaacauguag gcggccagca ug                                                22


<210>  281
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-182 targeting domain

<400>  281
uuucauuucc cgagaaggga ga                                                22


<210>  282
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-183 targeting domain

<400>  282
gggaagaccc aaugacugga ga                                                22


<210>  283
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-184 targeting domain

<400>  283
aaaacugagg cagggagagg gg                                                22


<210>  284
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-185 targeting domain

<400>  284
ugagucagac ccaggcuggg ca                                                22


<210>  285
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-186 targeting domain

<400>  285
gggauuugag gaggccuugg gg                                                22


<210>  286
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-187 targeting domain

<400>  286
ucugggggcc caagcucagg gu                                                22


<210>  287
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-188 targeting domain

<400>  287
cgggcccaca ggaugcaauu ug                                                22


<210>  288
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-189 targeting domain

<400>  288
acguagagcg ugaggaaguu ga                                                22


<210>  289
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-190 targeting domain

<400>  289
gaccgaggca gcagccugga ca                                                22


<210>  290
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-191 targeting domain

<400>  290
caggcugggc acugagggag ag                                                22


<210>  291
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-192 targeting domain

<400>  291
uauuucauuu cccgagaagg ga                                                22


<210>  292
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-193 targeting domain

<400>  292
gucccgggcu uggcgguggu gg                                                22


<210>  293
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-194 targeting domain

<400>  293
cugcugccuc ggucccauuc uc                                                22


<210>  294
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-195 targeting domain

<400>  294
agcgucuccu ccugcaucuc ag                                                22


<210>  295
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-196 targeting domain

<400>  295
ucagacccag gcugggcacu ga                                                22


<210>  296
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-197 targeting domain

<400>  296
agcuacccuc ucccugucua gg                                                22


<210>  297
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-198 targeting domain

<400>  297
cagagaggaa aacugaggca gg                                                22


<210>  298
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-199 targeting domain

<400>  298
ggagagggau uugaggaggc cu                                                22


<210>  299
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-200 targeting domain

<400>  299
guccuuccuc ccucucccuu cu                                                22


<210>  300
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-201 targeting domain

<400>  300
agagagcuug gugcugggag ga                                                22


<210>  301
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-202 targeting domain

<400>  301
ccuucucggg aaaugaaaua ac                                                22


<210>  302
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-203 targeting domain

<400>  302
gcgguucuca acaccaggag ac                                                22


<210>  303
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-204 targeting domain

<400>  303
cucugggggc ccaagcucag gg                                                22


<210>  304
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-205 targeting domain

<400>  304
ugugcaggag cccgggagca ug                                                22


<210>  305
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-206 targeting domain

<400>  305
cagagaggug uagagggugc ug                                                22


<210>  306
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-207 targeting domain

<400>  306
cuccccgaag cggaaguugc uc                                                22


<210>  307
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-208 targeting domain

<400>  307
gcuagaagca gccauugcaa ag                                                22


<210>  308
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-209 targeting domain

<400>  308
caaacaccau ucauggugau ag                                                22


<210>  309
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-210 targeting domain

<400>  309
ucauuucccg agaagggaga gg                                                22


<210>  310
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-211 targeting domain

<400>  310
ucaccacccc augaaguucc au                                                22


<210>  311
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-212 targeting domain

<400>  311
gggagugcac ccuccuuagg ca                                                22


<210>  312
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-213 targeting domain

<400>  312
aauggccaga gauucccuga ga                                                22


<210>  313
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-214 targeting domain

<400>  313
agaaugggac cgaggcagca gc                                                22


<210>  314
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-215 targeting domain

<400>  314
ggcaagccag accccuccuc uc                                                22


<210>  315
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-216 targeting domain

<400>  315
cccgggcuug gcgguggugg cu                                                22


<210>  316
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-217 targeting domain

<400>  316
agcccgggag cauggagggg uc                                                22


<210>  317
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-218 targeting domain

<400>  317
ccggguuauu ucauuucccg ag                                                22


<210>  318
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-219 targeting domain

<400>  318
gguguuuguu gacugaauau au                                                22


<210>  319
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-220 targeting domain

<400>  319
ccgucccugu gugacgcccc ag                                                22


<210>  320
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-221 targeting domain

<400>  320
ggacaggggc ugagagggga gg                                                22


<210>  321
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-222 targeting domain

<400>  321
agagggugcu ggugaagcca cc                                                22


<210>  322
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-223 targeting domain

<400>  322
auugcauccu gugggcccga ag                                                22


<210>  323
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-224 targeting domain

<400>  323
cggguuauuu cauuucccga ga                                                22


<210>  324
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-225 targeting domain

<400>  324
ggaaaugaaa uaacccggac au                                                22


<210>  325
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-226 targeting domain

<400>  325
cugacucagc acagcugcuc ca                                                22


<210>  326
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-227 targeting domain

<400>  326
ggcaccugag gacaggggcu ga                                                22


<210>  327
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-228 targeting domain

<400>  327
ggagagcugg gcaaagaaau uc                                                22


<210>  328
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-229 targeting domain

<400>  328
gggcgguaug agccgggugu gg                                                22


<210>  329
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-230 targeting domain

<400>  329
ccucccucuc ccuucucggg aa                                                22


<210>  330
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-231 targeting domain

<400>  330
uccagguaau ggcacugagc ag                                                22


<210>  331
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-232 targeting domain

<400>  331
gugggggccu cuccuaggag cc                                                22


<210>  332
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-233 targeting domain

<400>  332
gauggcaugg uucuccccga ag                                                22


<210>  333
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-234 targeting domain

<400>  333
cgucgcauug gagaagggca cg                                                22


<210>  334
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-235 targeting domain

<400>  334
uggguggggu gugcaggagc cc                                                22


<210>  335
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-236 targeting domain

<400>  335
cuggacggug acguagagcg ug                                                22


<210>  336
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-237 targeting domain

<400>  336
gaggaaaacu gaggcaggga ga                                                22


<210>  337
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-238 targeting domain

<400>  337
cugaacacug ccuugaucuu au                                                22


<210>  338
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-239 targeting domain

<400>  338
cauuaccugg accagccggc ga                                                22


<210>  339
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-240 targeting domain

<400>  339
ggagagagcu uggugcuggg ag                                                22


<210>  340
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-241 targeting domain

<400>  340
agaauaaugu cuugcauuua ac                                                22


<210>  341
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-242 targeting domain

<400>  341
cuaggaaggc aaccaggagu gg                                                22


<210>  342
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-243 targeting domain

<400>  342
ucucccagac cccuccaugc uc                                                22


<210>  343
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-244 targeting domain

<400>  343
acaggggcug agaggggagg ca                                                22


<210>  344
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-245 targeting domain

<400>  344
ggggcagagg gaccacacgc ug                                                22


<210>  345
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-246 targeting domain

<400>  345
aggggaggca gaggaugcca ga                                                22


<210>  346
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-247 targeting domain

<400>  346
ugguccaggu aauggcacug ag                                                22


<210>  347
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-248 targeting domain

<400>  347
ccggacaugu gggggccucu cc                                                22


<210>  348
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-249 targeting domain

<400>  348
gcaggccagc gccaugaccc ag                                                22


<210>  349
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-250 targeting domain

<400>  349
cuagcuaccc ucucccuguc ua                                                22


<210>  350
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-251 targeting domain

<400>  350
gcuuuggaua acauugacag ga                                                22


<210>  351
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-252 targeting domain

<400>  351
gccauugcaa agcuggguga cg                                                22


<210>  352
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-253 targeting domain

<400>  352
ccuaggucuc cuggcuguga uc                                                22


<210>  353
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-254 targeting domain

<400>  353
aacagagagg aaaacugagg ca                                                22


<210>  354
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-255 targeting domain

<400>  354
auuaccugga ccagccggcg ag                                                22


<210>  355
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-256 targeting domain

<400>  355
gaggggcacc ugaggacagg gg                                                22


<210>  356
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-257 targeting domain

<400>  356
ggguuauuuc auuucccgag aa                                                22


<210>  357
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-258 targeting domain

<400>  357
agggugcacu ccccccuaga ca                                                22


<210>  358
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-259 targeting domain

<400>  358
ccaggagugg gagagggauu ug                                                22


<210>  359
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-260 targeting domain

<400>  359
agaggggagg cagaggaugc ca                                                22


<210>  360
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-261 targeting domain

<400>  360
ccgccugcug acugccuugc ag                                                22


<210>  361
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-262 targeting domain

<400>  361
ggcuuggugc ugcaaacaug gc                                                22


<210>  362
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-263 targeting domain

<400>  362
cagguaaugg cacugagcag aa                                                22


<210>  363
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-264 targeting domain

<400>  363
uuggaacgcg gcagggaggc ug                                                22


<210>  364
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-265 targeting domain

<400>  364
uguccggguu auuucauuuc cc                                                22


<210>  365
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-266 targeting domain

<400>  365
cagguaguac uguggguacu cg                                                22


<210>  366
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-267 targeting domain

<400>  366
auaacagauc ccacuuaaca ga                                                22


<210>  367
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-268 targeting domain

<400>  367
agggacgggu gcagaguuga gu                                                22


<210>  368
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-269 targeting domain

<400>  368
gaaggagaga gcuuggugcu gg                                                22


<210>  369
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-270 targeting domain

<400>  369
ggucagccac ggcuagguug ag                                                22


<210>  370
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-271 targeting domain

<400>  370
auuucacagc aagaaaacug ag                                                22


<210>  371
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-272 targeting domain

<400>  371
ucaaagaagu caagcgcccu gc                                                22


<210>  372
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-273 targeting domain

<400>  372
gcugcuccca cccaagaaug cu                                                22


<210>  373
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-274 targeting domain

<400>  373
gcaacaaaca cccaacaaug gc                                                22


<210>  374
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-275 targeting domain

<400>  374
aaauccacuu cccacccuga gc                                                22


<210>  375
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-276 targeting domain

<400>  375
cagggaggcu ggaggggcac cu                                                22


<210>  376
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-277 targeting domain

<400>  376
gggcaagcca gaccccuccu cu                                                22


<210>  377
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-278 targeting domain

<400>  377
caggaaaaca gauggggugc ug                                                22


<210>  378
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-279 targeting domain

<400>  378
uuggagaagg gcacguagaa gu                                                22


<210>  379
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-280 targeting domain

<400>  379
agagcuuggu gcugggagga gg                                                22


<210>  380
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-281 targeting domain

<400>  380
uagcuaggaa ggcaaccagg ag                                                22


<210>  381
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-282 targeting domain

<400>  381
ggcuagguug agcaggaugu ag                                                22


<210>  382
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-283 targeting domain

<400>  382
cucaccaccc caugaaguuc ca                                                22


<210>  383
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-284 targeting domain

<400>  383
aagcaaugug caauguuuug cc                                                22


<210>  384
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-285 targeting domain

<400>  384
ggaagaccca augacuggag aa                                                22


<210>  385
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-286 targeting domain

<400>  385
uggccaggac caccaaggac ca                                                22


<210>  386
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-287 targeting domain

<400>  386
aaauauuguc ccuuucacug uu                                                22


<210>  387
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-288 targeting domain

<400>  387
caugagcaac uuccgcuucg gg                                                22


<210>  388
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-289 targeting domain

<400>  388
agagauauuc cuggaucaca gc                                                22


<210>  389
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-290 targeting domain

<400>  389
cauggagggg ucugggagag uc                                                22


<210>  390
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-291 targeting domain

<400>  390
auguuuugcc cagaggaaga ag                                                22


<210>  391
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-292 targeting domain

<400>  391
gugggugggg ugugcaggag cc                                                22


<210>  392
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-293 targeting domain

<400>  392
ccagguaaug gcacugagca ga                                                22


<210>  393
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-294 targeting domain

<400>  393
cccaacaaug gccagagauu cc                                                22


<210>  394
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-295 targeting domain

<400>  394
gcaccugagg acaggggcug ag                                                22


<210>  395
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-296 targeting domain

<400>  395
gucagaccca ggcugggcac ug                                                22


<210>  396
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-297 targeting domain

<400>  396
ggggcaccug aggacagggg cu                                                22


<210>  397
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-298 targeting domain

<400>  397
agaggaaaac ugaggcaggg ag                                                22


<210>  398
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-299 targeting domain

<400>  398
agggauaaca gaucccacuu aa                                                22


<210>  399
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-300 targeting domain

<400>  399
cuuggugcug ggaggagggg ga                                                22


<210>  400
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-301 targeting domain

<400>  400
agaggguagc uaggaaggca ac                                                22


<210>  401
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-302 targeting domain

<400>  401
uugcacauug cuucauggcu cc                                                22


<210>  402
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-303 targeting domain

<400>  402
gaccgagccc auugcccagc ac                                                22


<210>  403
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-304 targeting domain

<400>  403
ugaacacugc cuugaucuua uu                                                22


<210>  404
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-305 targeting domain

<400>  404
ggugcacucc ccccuagaca gg                                                22


<210>  405
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-306 targeting domain

<400>  405
gcuuggugcu gggaggaggg gg                                                22


<210>  406
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-307 targeting domain

<400>  406
ggauacuucg ucuucgggcc ca                                                22


<210>  407
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-308 targeting domain

<400>  407
agucagaccc aggcugggca cu                                                22


<210>  408
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-309 targeting domain

<400>  408
agcaccaagc cucuguuucc cu                                                22


<210>  409
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-310 targeting domain

<400>  409
ugggcaaaga aauuccaggg aa                                                22


<210>  410
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-311 targeting domain

<400>  410
agagggauuu gaggaggccu ug                                                22


<210>  411
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-312 targeting domain

<400>  411
gcaauguuuu gcccagagga ag                                                22


<210>  412
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-313 targeting domain

<400>  412
cauguccggg uuauuucauu uc                                                22


<210>  413
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-314 targeting domain

<400>  413
aagcccauga gcaacuuccg cu                                                22


<210>  414
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-315 targeting domain

<400>  414
ucccacccug agcuugggcc cc                                                22


<210>  415
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-316 targeting domain

<400>  415
gagagagcuu ggugcuggga gg                                                22


<210>  416
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-317 targeting domain

<400>  416
cuacgugccc uucuccaaug cg                                                22


<210>  417
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-318 targeting domain

<400>  417
cuugcauuua acaggaaaac ag                                                22


<210>  418
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-319 targeting domain

<400>  418
gaaaugaaau aacccggaca ug                                                22


<210>  419
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-320 targeting domain

<400>  419
cgaaggccug agcucagcca cu                                                22


<210>  420
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-321 targeting domain

<400>  420
ggagggugca cuccccccua ga                                                22


<210>  421
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-322 targeting domain

<400>  421
cagcaccaag ccucuguuuc cc                                                22


<210>  422
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-323 targeting domain

<400>  422
gggcaaagaa auuccaggga au                                                22


<210>  423
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-324 targeting domain

<400>  423
cuucggggag aaccaugcca uc                                                22


<210>  424
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-325 targeting domain

<400>  424
ugggaggagg gggaaggggc ag                                                22


<210>  425
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-326 targeting domain

<400>  425
ccuagacagg gagaggguag cu                                                22


<210>  426
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-327 targeting domain

<400>  426
uaacagagag gaaaacugag gc                                                22


<210>  427
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-328 targeting domain

<400>  427
ucucagccac caccgccaag cc                                                22


<210>  428
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-329 targeting domain

<400>  428
gucagcacag accccacugc cu                                                22


<210>  429
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-330 targeting domain

<400>  429
aggaaaacug aggcagggag ag                                                22


<210>  430
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-331 targeting domain

<400>  430
agccauugca aagcugggug ac                                                22


<210>  431
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-332 targeting domain

<400>  431
aaaugaaaua acccggacau gu                                                22


<210>  432
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-333 targeting domain

<400>  432
uagcuacccu cucccugucu ag                                                22


<210>  433
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-334 targeting domain

<400>  433
uguggguggg gugugcagga gc                                                22


<210>  434
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-335 targeting domain

<400>  434
uggggaagga gagagcuugg ug                                                22


<210>  435
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-336 targeting domain

<400>  435
gacuuggaac gcggcaggga gg                                                22


<210>  436
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-337 targeting domain

<400>  436
aaggagagag cuuggugcug gg                                                22


<210>  437
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-338 targeting domain

<400>  437
gggaaggaga gagcuuggug cu                                                22


<210>  438
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-339 targeting domain

<400>  438
auuugaggag gccuugggga ag                                                22


<210>  439
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-340 targeting domain

<400>  439
auccagcugg agcccugagu gg                                                22


<210>  440
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-341 targeting domain

<400>  440
gagagcuugg ugcugggagg ag                                                22


<210>  441
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-342 targeting domain

<400>  441
uccuagcuac ccucucccug uc                                                22


<210>  442
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-343 targeting domain

<400>  442
ccgaggcagc agccuggaca ug                                                22


<210>  443
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-344 targeting domain

<400>  443
ggggaaggag agagcuuggu gc                                                22


<210>  444
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-345 targeting domain

<400>  444
ugcugggagg agggggaagg gg                                                22


<210>  445
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-346 targeting domain

<400>  445
cuucuugugc uggacgguga cg                                                22


<210>  446
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-347 targeting domain

<400>  446
uaccacaccc gucgcauugg ag                                                22


<210>  447
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-348 targeting domain

<400>  447
agcagccugg acauggggga ga                                                22


<210>  448
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-349 targeting domain

<400>  448
agccagguag uacugugggu ac                                                22


<210>  449
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-350 targeting domain

<400>  449
ggcugcuugc gguucucaac ac                                                22


<210>  450
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-351 targeting domain

<400>  450
ggaccgaggc agcagccugg ac                                                22


<210>  451
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-352 targeting domain

<400>  451
cugggcaaag aaauuccagg ga                                                22


<210>  452
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-353 targeting domain

<400>  452
ugagagggga ggcagaggau gc                                                22


<210>  453
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-354 targeting domain

<400>  453
gagggugcac uccccccuag ac                                                22


<210>  454
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-355 targeting domain

<400>  454
cgguucucaa caccaggaga cu                                                22


<210>  455
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-356 targeting domain

<400>  455
ugugcaaugu uuugcccaga gg                                                22


<210>  456
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-357 targeting domain

<400>  456
gggggagaca gggcaaggcu gg                                                22


<210>  457
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-358 targeting domain

<400>  457
gccgggugug gguggggugu gc                                                22


<210>  458
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-359 targeting domain

<400>  458
cugcguacca cacccgucgc au                                                22


<210>  459
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-360 targeting domain

<400>  459
cacccaagaa ugcugcgaag gc                                                22


<210>  460
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-361 targeting domain

<400>  460
ccuagcuacc cucucccugu cu                                                22


<210>  461
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-362 targeting domain

<400>  461
caccaggaga cuuggaacgc gg                                                22


<210>  462
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-363 targeting domain

<400>  462
uuggauaaca uugacaggac ag                                                22


<210>  463
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-364 targeting domain

<400>  463
uucgggccca caggaugcaa uu                                                22


<210>  464
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-365 targeting domain

<400>  464
gaaguaucca ugcagagagg ug                                                22


<210>  465
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-366 targeting domain

<400>  465
ggugugcagg agcccgggag ca                                                22


<210>  466
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-367 targeting domain

<400>  466
ggagcagcca cgggucagcc ac                                                22


<210>  467
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-368 targeting domain

<400>  467
agcgcccugc uggggcguca ca                                                22


<210>  468
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-369 targeting domain

<400>  468
gagcccggga gcauggaggg gu                                                22


<210>  469
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-370 targeting domain

<400>  469
agggccacag ccaugaaugg ca                                                22


<210>  470
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-371 targeting domain

<400>  470
gcaaugugca auguuuugcc ca                                                22


<210>  471
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-372 targeting domain

<400>  471
gaagagguca gccacggcua gg                                                22


<210>  472
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-373 targeting domain

<400>  472
ggccuucgca gcauucuugg gu                                                22


<210>  473
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-374 targeting domain

<400>  473
uuaacagaga ggaaaacuga gg                                                22


<210>  474
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-375 targeting domain

<400>  474
ugauggcaug guucuccccg aa                                                22


<210>  475
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-376 targeting domain

<400>  475
accgaggcag cagccuggac au                                                22


<210>  476
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-377 targeting domain

<400>  476
agggaccaca cgcugaggag ag                                                22


<210>  477
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-378 targeting domain

<400>  477
uggaacgcgg cagggaggcu gg                                                22


<210>  478
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-379 targeting domain

<400>  478
ugcacauugc uucauggcuc cu                                                22


<210>  479
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-380 targeting domain

<400>  479
gcguuccaag ucuccuggug uu                                                22


<210>  480
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-381 targeting domain

<400>  480
gggugugcag gagcccggga gc                                                22


<210>  481
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-382 targeting domain

<400>  481
ggcaaagaaa uuccagggaa ug                                                22


<210>  482
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-383 targeting domain

<400>  482
ggcuggaggg gcaccugagg ac                                                22


<210>  483
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-384 targeting domain

<400>  483
gcgcccugcu ggggcgucac ac                                                22


<210>  484
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-385 targeting domain

<400>  484
gcguaccaca cccgucgcau ug                                                22


<210>  485
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-386 targeting domain

<400>  485
accaggagac uuggaacgcg gc                                                22


<210>  486
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-387 targeting domain

<400>  486
gcugcugccu cggucccauu cu                                                22


<210>  487
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-388 targeting domain

<400>  487
gaagcccucc aaauugcauc cu                                                22


<210>  488
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-389 targeting domain

<400>  488
cguagagcgu gaggaaguug au                                                22


<210>  489
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-390 targeting domain

<400>  489
cugaagcagu uccuuuuugc uu                                                22


<210>  490
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-391 targeting domain

<400>  490
gcuggacggu gacguagagc gu                                                22


<210>  491
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-392 targeting domain

<400>  491
ugagggcuuu ggauaacauu ga                                                22


<210>  492
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-393 targeting domain

<400>  492
agccgggugu ggguggggug ug                                                22


<210>  493
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-394 targeting domain

<400>  493
cucaguuuuc cucucuguua ag                                                22


<210>  494
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-395 targeting domain

<400>  494
caagacauua uucuaaagca aa                                                22


<210>  495
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-396 targeting domain

<400>  495
uggaacuuca ugggguggug ag                                                22


<210>  496
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-397 targeting domain

<400>  496
gagagggauu ugaggaggcc uu                                                22


<210>  497
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-398 targeting domain

<400>  497
cuucgggccc acaggaugca au                                                22


<210>  498
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-399 targeting domain

<400>  498
acuuggaacg cggcagggag gc                                                22


<210>  499
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-400 targeting domain

<400>  499
auggccagag auucccugag aa                                                22


<210>  500
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-401 targeting domain

<400>  500
ccucaguuuu ccucucuguu aa                                                22


<210>  501
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-402 targeting domain

<400>  501
uaacagaucc cacuuaacag ag                                                22


<210>  502
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RHO-403 targeting domain

<400>  502
gggagaggga uuugaggagg cc                                                22


<210>  503

<400>  503
000

<210>  504

<400>  504
000

<210>  505

<400>  505
000

<210>  506

<400>  506
000

<210>  507

<400>  507
000

<210>  508

<400>  508
000

<210>  509

<400>  509
000

<210>  510

<400>  510
000

<210>  511

<400>  511
000

<210>  512

<400>  512
000

<210>  513

<400>  513
000

<210>  514

<400>  514
000

<210>  515

<400>  515
000

<210>  516

<400>  516
000

<210>  517

<400>  517
000

<210>  518

<400>  518
000

<210>  519

<400>  519
000

<210>  520

<400>  520
000

<210>  521

<400>  521
000

<210>  522

<400>  522
000

<210>  523

<400>  523
000

<210>  524

<400>  524
000

<210>  525

<400>  525
000

<210>  526

<400>  526
000

<210>  527

<400>  527
000

<210>  528

<400>  528
000

<210>  529

<400>  529
000

<210>  530

<400>  530
000

<210>  531

<400>  531
000

<210>  532

<400>  532
000

<210>  533

<400>  533
000

<210>  534

<400>  534
000

<210>  535

<400>  535
000

<210>  536

<400>  536
000

<210>  537

<400>  537
000

<210>  538

<400>  538
000

<210>  539

<400>  539
000

<210>  540

<400>  540
000

<210>  541

<400>  541
000

<210>  542

<400>  542
000

<210>  543

<400>  543
000

<210>  544

<400>  544
000

<210>  545

<400>  545
000

<210>  546

<400>  546
000

<210>  547

<400>  547
000

<210>  548

<400>  548
000

<210>  549

<400>  549
000

<210>  550

<400>  550
000

<210>  551

<400>  551
000

<210>  552

<400>  552
000

<210>  553

<400>  553
000

<210>  554

<400>  554
000

<210>  555

<400>  555
000

<210>  556

<400>  556
000

<210>  557

<400>  557
000

<210>  558

<400>  558
000

<210>  559

<400>  559
000

<210>  560

<400>  560
000

<210>  561

<400>  561
000

<210>  562

<400>  562
000

<210>  563

<400>  563
000

<210>  564

<400>  564
000

<210>  565

<400>  565
000

<210>  566

<400>  566
000

<210>  567

<400>  567
000

<210>  568

<400>  568
000

<210>  569

<400>  569
000

<210>  570

<400>  570
000

<210>  571

<400>  571
000

<210>  572

<400>  572
000

<210>  573

<400>  573
000

<210>  574

<400>  574
000

<210>  575

<400>  575
000

<210>  576

<400>  576
000

<210>  577

<400>  577
000

<210>  578

<400>  578
000

<210>  579

<400>  579
000

<210>  580

<400>  580
000

<210>  581

<400>  581
000

<210>  582

<400>  582
000

<210>  583

<400>  583
000

<210>  584

<400>  584
000

<210>  585

<400>  585
000

<210>  586

<400>  586
000

<210>  587

<400>  587
000

<210>  588

<400>  588
000

<210>  589

<400>  589
000

<210>  590

<400>  590
000

<210>  591

<400>  591
000

<210>  592

<400>  592
000

<210>  593

<400>  593
000

<210>  594

<400>  594
000

<210>  595

<400>  595
000

<210>  596

<400>  596
000

<210>  597

<400>  597
000

<210>  598

<400>  598
000

<210>  599

<400>  599
000

<210>  600
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-1 targeting domain

<400>  600
gtcagccaca agggccacag cc                                                22


<210>  601
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-2 targeting domain

<400>  601
ccgaagacga agtatccatg ca                                                22


<210>  602
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-3 targeting domain

<400>  602
agtatccatg cagagaggtg ta                                                22


<210>  603
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-4 targeting domain

<400>  603
ctaggttgag caggatgtag tt                                                22


<210>  604
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-5 targeting domain

<400>  604
catggctcag ccaggtagta ct                                                22


<210>  605
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-6 targeting domain

<400>  605
acgggtgtgg tacgcagccc ct                                                22


<210>  606
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-7 targeting domain

<400>  606
cccacacccg gctcataccg cc                                                22


<210>  607
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-8 targeting domain

<400>  607
ccctgggcgg tatgagccgg gt                                                22


<210>  608
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-9 targeting domain

<400>  608
ccatcatggg cgttgccttc ac                                                22


<210>  609
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-10 targeting domain

<400>  609
gtgccattac ctggaccagc cg                                                22


<210>  610
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-11 targeting domain

<400>  610
ttacctggac cagccggcga gt                                                22


<210>  611
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-12 targeting domain

<400>  611
gcattcttgg gtgggagcag cc                                                22


<210>  612
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-13 targeting domain

<400>  612
gctcagccac tcagggctcc ag                                                22


<210>  613
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-14 targeting domain

<400>  613
tgacccgtgg ctgctcccac cc                                                22


<210>  614
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-15 targeting domain

<400>  614
agctcaggcc ttcgcagcat tc                                                22


<210>  615
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-16 targeting domain

<400>  615
tagcagaaga atgcatccta at                                                22


<210>  616
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-17 targeting domain

<400>  616
acacgctgag gagagctggg ca                                                22


<210>  617
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-18 targeting domain

<400>  617
gcaaataact tcccccattc cc                                                22


<210>  618
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-19 targeting domain

<400>  618
agacccaggc tgggcactga gg                                                22


<210>  619
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-20 targeting domain

<400>  619
ctaggtctcc tggctgtgat cc                                                22


<210>  620
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-21 targeting domain

<400>  620
ccagaaggtg ggtgtgccac tt                                                22


<210>  621
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-22 targeting domain

<400>  621
aacaaggaac tctgccccac at                                                22


<210>  622
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-23 targeting domain

<400>  622
caggattgaa ctgggaaccc gg                                                22


<210>  623
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-24 targeting domain

<400>  623
gggcgtcaca cagggacggg tg                                                22


<210>  624
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-25 targeting domain

<400>  624
ctgtgatcca ggaatatctc tg                                                22


<210>  625
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-26 targeting domain

<400>  625
ttgcatttaa caggaaaaca ga                                                22


<210>  626
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-27 targeting domain

<400>  626
ggagtgcacc ctccttaggc ag                                                22


<210>  627
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-28 targeting domain

<400>  627
catctgtcct gctcaccacc cc                                                22


<210>  628
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-29 targeting domain

<400>  628
gaggggaggc agaggatgcc ag                                                22


<210>  629
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-30 targeting domain

<400>  629
ctcagggaat ctctggccat tg                                                22


<210>  630
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-31 targeting domain

<400>  630
tgcactcccc cctagacagg ga                                                22


<210>  631
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-32 targeting domain

<400>  631
tgctgtttgt gcagggctgg ca                                                22


<210>  632
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-33 targeting domain

<400>  632
actgggacat tcctaacagt ga                                                22


<210>  633
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-34 targeting domain

<400>  633
atcagggggt caggattgaa ct                                                22


<210>  634
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-35 targeting domain

<400>  634
ctcctctctg ggggcccaag ct                                                22


<210>  635
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-36 targeting domain

<400>  635
ctgcatctca gcagagatat tc                                                22


<210>  636
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-37 targeting domain

<400>  636
tgtttccctt ggagcagctg tg                                                22


<210>  637
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-38 targeting domain

<400>  637
gcgctctggg cccataaggg ac                                                22


<210>  638
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-39 targeting domain

<400>  638
aggattgaac tgggaacccg gt                                                22


<210>  639
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-40 targeting domain

<400>  639
cctaggagag gcccccacat gt                                                22


<210>  640
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-41 targeting domain

<400>  640
atcactcagt tctggccaga ag                                                22


<210>  641
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-42 targeting domain

<400>  641
agagctgggc aaagaaattc ca                                                22


<210>  642
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-43 targeting domain

<400>  642
ccaccccatg aagttccata gg                                                22


<210>  643
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-44 targeting domain

<400>  643
ccaccctgag cttgggcccc ca                                                22


<210>  644
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-45 targeting domain

<400>  644
cagaggaaga agaaggaaat ga                                                22


<210>  645
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-46 targeting domain

<400>  645
aaacagcagc ccggctatca cc                                                22


<210>  646
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-47 targeting domain

<400>  646
ggattgaact gggaacccgg ta                                                22


<210>  647
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-48 targeting domain

<400>  647
tgtgtgtgtg tgtgtttagc ag                                                22


<210>  648
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-49 targeting domain

<400>  648
tcacacaggg acgggtgcag ag                                                22


<210>  649
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-50 targeting domain

<400>  649
gtgtgtgtgt gtgtgtgttt ag                                                22


<210>  650
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-51 targeting domain

<400>  650
tgagcttggg cccccagaga gg                                                22


<210>  651
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-52 targeting domain

<400>  651
aatatctctg ctgagatgca gg                                                22


<210>  652
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-53 targeting domain

<400>  652
ggagagggga agagactcat tt                                                22


<210>  653
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-54 targeting domain

<400>  653
agaactgagt gatctgtgat ta                                                22


<210>  654
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-55 targeting domain

<400>  654
ccactctccc tatggaactt ca                                                22


<210>  655
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-56 targeting domain

<400>  655
ataagggaca cgaatcagat ca                                                22


<210>  656
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-57 targeting domain

<400>  656
tggattttcc attctccagt ca                                                22


<210>  657
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-58 targeting domain

<400>  657
gtgcaggagc ccgggagcat gg                                                22


<210>  658
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-59 targeting domain

<400>  658
gggtggtgag caggacagat gt                                                22


<210>  659
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-60 targeting domain

<400>  659
cagctctccc tcagtgccca gc                                                22


<210>  660
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-61 targeting domain

<400>  660
cctgctgggg cgtcacacag gg                                                22


<210>  661
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-62 targeting domain

<400>  661
cacacacaca caaaactccc ta                                                22


<210>  662
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-63 targeting domain

<400>  662
acttacgggt ggttgttctc tg                                                22


<210>  663
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-64 targeting domain

<400>  663
cacagggaag acccaatgac tg                                                22


<210>  664
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-65 targeting domain

<400>  664
agcacagacc ccactgccta ag                                                22


<210>  665
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-66 targeting domain

<400>  665
acctgaggac aggggctgag ag                                                22


<210>  666
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-67 targeting domain

<400>  666
caacaatggc cagagattcc ct                                                22


<210>  667
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-68 targeting domain

<400>  667
tgctgcctcg gtcccattct ca                                                22


<210>  668
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-69 targeting domain

<400>  668
tgctgcctgg ccacatccct aa                                                22


<210>  669
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-70 targeting domain

<400>  669
gccactctcc ctatggaact tc                                                22


<210>  670
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-71 targeting domain

<400>  670
gagggaggaa ggactgccaa tt                                                22


<210>  671
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-72 targeting domain

<400>  671
gagggtagct aggaaggcaa cc                                                22


<210>  672
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-73 targeting domain

<400>  672
ggaaggcaac caggagtggg ag                                                22


<210>  673
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-74 targeting domain

<400>  673
gctgagatgc aggaggagac gc                                                22


<210>  674
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-75 targeting domain

<400>  674
aggctggagg ggcacctgag ga                                                22


<210>  675
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-76 targeting domain

<400>  675
aggaaggcaa ccaggagtgg ga                                                22


<210>  676
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-77 targeting domain

<400>  676
ccgggagcat ggaggggtct gg                                                22


<210>  677
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-78 targeting domain

<400>  677
ggataacaga tcccacttaa ca                                                22


<210>  678
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-79 targeting domain

<400>  678
aggcagagga tgccagaggg ga                                                22


<210>  679
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-80 targeting domain

<400>  679
gggcccaagc tcagggtggg aa                                                22


<210>  680
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-81 targeting domain

<400>  680
taactatatg gccactctcc ct                                                22


<210>  681
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-82 targeting domain

<400>  681
tcccacttaa cagagaggaa aa                                                22


<210>  682
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-83 targeting domain

<400>  682
gaatgcagag gtggtggaaa cc                                                22


<210>  683
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-84 targeting domain

<400>  683
gggagacagg gcaaggctgg ca                                                22


<210>  684
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-85 targeting domain

<400>  684
caccacccca tgaagttcca ta                                                22


<210>  685
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-86 targeting domain

<400>  685
gccatatagt taatcaacca aa                                                22


<210>  686
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-87 targeting domain

<400>  686
gtagctagga aggcaaccag ga                                                22


<210>  687
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-88 targeting domain

<400>  687
cacattgctt catggctcct ag                                                22


<210>  688
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-89 targeting domain

<400>  688
ctgagcttgg gcccccagag ag                                                22


<210>  689
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-90 targeting domain

<400>  689
accgagccca ttgcccagca ca                                                22


<210>  690
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-91 targeting domain

<400>  690
ctcaaagaag tcaagcgccc tg                                                22


<210>  691
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-92 targeting domain

<400>  691
gctaccctct ccctgtctag gg                                                22


<210>  692
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-93 targeting domain

<400>  692
accctgagct tgggccccca ga                                                22


<210>  693
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-94 targeting domain

<400>  693
ggcagaggga ccacacgctg ag                                                22


<210>  694
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-95 targeting domain

<400>  694
tctgactcag cacagctgct cc                                                22


<210>  695
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-96 targeting domain

<400>  695
ctctcagcca ccaccgccaa gc                                                22


<210>  696
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-97 targeting domain

<400>  696
agggatgtgg ccaggcagca ac                                                22


<210>  697
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-98 targeting domain

<400>  697
cacctgagga caggggctga ga                                                22


<210>  698
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-99 targeting domain

<400>  698
gcccatgatg gcatggttct cc                                                22


<210>  699
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-100 targeting domain

<400>  699
gaaggggcag agggaccaca cg                                                22


<210>  700
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-101 targeting domain

<400>  700
agcaccctct acacctctct gc                                                22


<210>  701
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-102 targeting domain

<400>  701
ctttggataa cattgacagg ac                                                22


<210>  702
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-103 targeting domain

<400>  702
ggtgaagcca cctaggacca tg                                                22


<210>  703
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-104 targeting domain

<400>  703
taacattgac aggacaggag aa                                                22


<210>  704
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-105 targeting domain

<400>  704
gggagagggg aagagactca tt                                                22


<210>  705
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-106 targeting domain

<400>  705
gctgtgctga gtcagaccca gg                                                22


<210>  706
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-107 targeting domain

<400>  706
ttgaggaggc cttggggaag ga                                                22


<210>  707
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-108 targeting domain

<400>  707
gcccgggagc atggaggggt ct                                                22


<210>  708
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-109 targeting domain

<400>  708
gtaaactggg actgaccctg ca                                                22


<210>  709
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-110 targeting domain

<400>  709
ataacattga caggacagga ga                                                22


<210>  710
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-111 targeting domain

<400>  710
ggcagggagg ctggaggggc ac                                                22


<210>  711
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-112 targeting domain

<400>  711
gcaaacatgg cccgagatag at                                                22


<210>  712
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-113 targeting domain

<400>  712
ggaccgagcc cattgcccag ca                                                22


<210>  713
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-114 targeting domain

<400>  713
gctctacgtc accgtccagc ac                                                22


<210>  714
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-115 targeting domain

<400>  714
agcacagctg ctccaaggga aa                                                22


<210>  715
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-116 targeting domain

<400>  715
ctaaagcaaa aaggaactgc tt                                                22


<210>  716
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-117 targeting domain

<400>  716
gagaggaaaa ctgaggcagg ga                                                22


<210>  717
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-118 targeting domain

<400>  717
cattgcaaag ctgggtgacg gg                                                22


<210>  718
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-119 targeting domain

<400>  718
ttgccaccct gggcggtatg ag                                                22


<210>  719
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-120 targeting domain

<400>  719
agctaggaag gcaaccagga gt                                                22


<210>  720
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-121 targeting domain

<400>  720
tctctggggg cccaagctca gg                                                22


<210>  721
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-122 targeting domain

<400>  721
agcacaggga agacccaatg ac                                                22


<210>  722
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-123 targeting domain

<400>  722
gttgactgaa tatatgaggg ct                                                22


<210>  723
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-124 targeting domain

<400>  723
ttgtaaactg ggactgaccc tg                                                22


<210>  724
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-125 targeting domain

<400>  724
cacacccacc ttctggccag aa                                                22


<210>  725
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-126 targeting domain

<400>  725
ccagaggaag aagaaggaaa tg                                                22


<210>  726
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-127 targeting domain

<400>  726
gagatattcc tggatcacag cc                                                22


<210>  727
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-128 targeting domain

<400>  727
aggggcagag ggaccacacg ct                                                22


<210>  728
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-129 targeting domain

<400>  728
aactatatgg ccactctccc ta                                                22


<210>  729
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-130 targeting domain

<400>  729
gctgcttgcg gttctcaaca cc                                                22


<210>  730
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-131 targeting domain

<400>  730
caccatgaat ggtgtttgtt ga                                                22


<210>  731
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-132 targeting domain

<400>  731
gcagccattg caaagctggg tg                                                22


<210>  732
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-133 targeting domain

<400>  732
tgactcagca cagctgctcc aa                                                22


<210>  733
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-134 targeting domain

<400>  733
ctgggaggag ggggaagggg ca                                                22


<210>  734
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-135 targeting domain

<400>  734
gataacattg acaggacagg ag                                                22


<210>  735
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-136 targeting domain

<400>  735
ccaaactggg acattcctaa ca                                                22


<210>  736
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-137 targeting domain

<400>  736
aggaaaacag atggggtgct gc                                                22


<210>  737
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-138 targeting domain

<400>  737
cggacatgtg ggggcctctc ct                                                22


<210>  738
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-139 targeting domain

<400>  738
gcaaagaaat tccagggaat gg                                                22


<210>  739
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-140 targeting domain

<400>  739
ccaggagact tggaacgcgg ca                                                22


<210>  740
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-141 targeting domain

<400>  740
tggtccttgg tggtcctggc ca                                                22


<210>  741
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-142 targeting domain

<400>  741
aatggaaaat ccacttccca cc                                                22


<210>  742
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-143 targeting domain

<400>  742
gcccgaagac gaagtatcca tg                                                22


<210>  743
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-144 targeting domain

<400>  743
gtgctggacg gtgacgtaga gc                                                22


<210>  744
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-145 targeting domain

<400>  744
agaaacatgt aggcggccag ca                                                22


<210>  745
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-146 targeting domain

<400>  745
ccgctcgatg gccaggacca cc                                                22


<210>  746
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-147 targeting domain

<400>  746
tcagcacaga ccccactgcc ta                                                22


<210>  747
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-148 targeting domain

<400>  747
gaatatctct gctgagatgc ag                                                22


<210>  748
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-149 targeting domain

<400>  748
gagtacccac agtactacct gg                                                22


<210>  749
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-150 targeting domain

<400>  749
caaccaggag tgggagaggg at                                                22


<210>  750
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-151 targeting domain

<400>  750
ttgagaaccg caagcagccg ct                                                22


<210>  751
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-152 targeting domain

<400>  751
gcaagccaga cccctcctct ct                                                22


<210>  752
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-153 targeting domain

<400>  752
gagagctggg caaagaaatt cc                                                22


<210>  753
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-154 targeting domain

<400>  753
cgaggcagca gcctggacat gg                                                22


<210>  754
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-155 targeting domain

<400>  754
aggaatatct ctgctgagat gc                                                22


<210>  755
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-156 targeting domain

<400>  755
ttcccgagaa gggagaggga gg                                                22


<210>  756
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-157 targeting domain

<400>  756
tccttcctcc ctctcccttc tc                                                22


<210>  757
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-158 targeting domain

<400>  757
tgttttgccc agaggaagaa ga                                                22


<210>  758
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-159 targeting domain

<400>  758
ccggctggtc caggtaatgg ca                                                22


<210>  759
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-160 targeting domain

<400>  759
cagcacaggg aagacccaat ga                                                22


<210>  760
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-161 targeting domain

<400>  760
accaggagtg ggagagggat tt                                                22


<210>  761
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-162 targeting domain

<400>  761
gctggtgaag ccacctagga cc                                                22


<210>  762
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-163 targeting domain

<400>  762
ggcggtatga gccgggtgtg gg                                                22


<210>  763
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-164 targeting domain

<400>  763
cagccattgc aaagctgggt ga                                                22


<210>  764
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-165 targeting domain

<400>  764
acattgacag gacaggagaa gg                                                22


<210>  765
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-166 targeting domain

<400>  765
tgggtcttcc ctgtgctggg ca                                                22


<210>  766
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-167 targeting domain

<400>  766
gtacgtggtg gtgtgtaagc cc                                                22


<210>  767
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-168 targeting domain

<400>  767
agcaaataac ttcccccatt cc                                                22


<210>  768
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-169 targeting domain

<400>  768
ggatttgagg aggccttggg ga                                                22


<210>  769
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-170 targeting domain

<400>  769
ccctgagctt gggcccccag ag                                                22


<210>  770
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-171 targeting domain

<400>  770
cagagattcc ctgagaatgg ga                                                22


<210>  771
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-172 targeting domain

<400>  771
gagttggaag cccgcatcta tc                                                22


<210>  772
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-173 targeting domain

<400>  772
agtccttcct ccctctccct tc                                                22


<210>  773
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-174 targeting domain

<400>  773
gttatttcat ttcccgagaa gg                                                22


<210>  774
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-175 targeting domain

<400>  774
atttcatttc ccgagaaggg ag                                                22


<210>  775
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-176 targeting domain

<400>  775
gacgtagagc gtgaggaagt tg                                                22


<210>  776
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-177 targeting domain

<400>  776
catttcccga gaagggagag gg                                                22


<210>  777
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-178 targeting domain

<400>  777
gtagagcgtg aggaagttga tg                                                22


<210>  778
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-179 targeting domain

<400>  778
caggccttcg cagcattctt gg                                                22


<210>  779
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-180 targeting domain

<400>  779
aggtagtact gtgggtactc ga                                                22


<210>  780
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-181 targeting domain

<400>  780
aaacatgtag gcggccagca tg                                                22


<210>  781
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-182 targeting domain

<400>  781
tttcatttcc cgagaaggga ga                                                22


<210>  782
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-183 targeting domain

<400>  782
gggaagaccc aatgactgga ga                                                22


<210>  783
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-184 targeting domain

<400>  783
aaaactgagg cagggagagg gg                                                22


<210>  784
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-185 targeting domain

<400>  784
tgagtcagac ccaggctggg ca                                                22


<210>  785
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-186 targeting domain

<400>  785
gggatttgag gaggccttgg gg                                                22


<210>  786
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-187 targeting domain

<400>  786
tctgggggcc caagctcagg gt                                                22


<210>  787
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-188 targeting domain

<400>  787
cgggcccaca ggatgcaatt tg                                                22


<210>  788
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-189 targeting domain

<400>  788
acgtagagcg tgaggaagtt ga                                                22


<210>  789
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-190 targeting domain

<400>  789
gaccgaggca gcagcctgga ca                                                22


<210>  790
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-191 targeting domain

<400>  790
caggctgggc actgagggag ag                                                22


<210>  791
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-192 targeting domain

<400>  791
tatttcattt cccgagaagg ga                                                22


<210>  792
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-193 targeting domain

<400>  792
gtcccgggct tggcggtggt gg                                                22


<210>  793
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-194 targeting domain

<400>  793
ctgctgcctc ggtcccattc tc                                                22


<210>  794
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-195 targeting domain

<400>  794
agcgtctcct cctgcatctc ag                                                22


<210>  795
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-196 targeting domain

<400>  795
tcagacccag gctgggcact ga                                                22


<210>  796
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-197 targeting domain

<400>  796
agctaccctc tccctgtcta gg                                                22


<210>  797
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-198 targeting domain

<400>  797
cagagaggaa aactgaggca gg                                                22


<210>  798
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-199 targeting domain

<400>  798
ggagagggat ttgaggaggc ct                                                22


<210>  799
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-200 targeting domain

<400>  799
gtccttcctc cctctccctt ct                                                22


<210>  800
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-201 targeting domain

<400>  800
agagagcttg gtgctgggag ga                                                22


<210>  801
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-202 targeting domain

<400>  801
ccttctcggg aaatgaaata ac                                                22


<210>  802
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-203 targeting domain

<400>  802
gcggttctca acaccaggag ac                                                22


<210>  803
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-204 targeting domain

<400>  803
ctctgggggc ccaagctcag gg                                                22


<210>  804
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-205 targeting domain

<400>  804
tgtgcaggag cccgggagca tg                                                22


<210>  805
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-206 targeting domain

<400>  805
cagagaggtg tagagggtgc tg                                                22


<210>  806
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-207 targeting domain

<400>  806
ctccccgaag cggaagttgc tc                                                22


<210>  807
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-208 targeting domain

<400>  807
gctagaagca gccattgcaa ag                                                22


<210>  808
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-209 targeting domain

<400>  808
caaacaccat tcatggtgat ag                                                22


<210>  809
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-210 targeting domain

<400>  809
tcatttcccg agaagggaga gg                                                22


<210>  810
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-211 targeting domain

<400>  810
tcaccacccc atgaagttcc at                                                22


<210>  811
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-212 targeting domain

<400>  811
gggagtgcac cctccttagg ca                                                22


<210>  812
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-213 targeting domain

<400>  812
aatggccaga gattccctga ga                                                22


<210>  813
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-214 targeting domain

<400>  813
agaatgggac cgaggcagca gc                                                22


<210>  814
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-215 targeting domain

<400>  814
ggcaagccag acccctcctc tc                                                22


<210>  815
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-216 targeting domain

<400>  815
cccgggcttg gcggtggtgg ct                                                22


<210>  816
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-217 targeting domain

<400>  816
agcccgggag catggagggg tc                                                22


<210>  817
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-218 targeting domain

<400>  817
ccgggttatt tcatttcccg ag                                                22


<210>  818
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-219 targeting domain

<400>  818
ggtgtttgtt gactgaatat at                                                22


<210>  819
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-220 targeting domain

<400>  819
ccgtccctgt gtgacgcccc ag                                                22


<210>  820
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-221 targeting domain

<400>  820
ggacaggggc tgagagggga gg                                                22


<210>  821
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-222 targeting domain

<400>  821
agagggtgct ggtgaagcca cc                                                22


<210>  822
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-223 targeting domain

<400>  822
attgcatcct gtgggcccga ag                                                22


<210>  823
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-224 targeting domain

<400>  823
cgggttattt catttcccga ga                                                22


<210>  824
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-225 targeting domain

<400>  824
ggaaatgaaa taacccggac at                                                22


<210>  825
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-226 targeting domain

<400>  825
ctgactcagc acagctgctc ca                                                22


<210>  826
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-227 targeting domain

<400>  826
ggcacctgag gacaggggct ga                                                22


<210>  827
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-228 targeting domain

<400>  827
ggagagctgg gcaaagaaat tc                                                22


<210>  828
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-229 targeting domain

<400>  828
gggcggtatg agccgggtgt gg                                                22


<210>  829
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-230 targeting domain

<400>  829
cctccctctc ccttctcggg aa                                                22


<210>  830
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-231 targeting domain

<400>  830
tccaggtaat ggcactgagc ag                                                22


<210>  831
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-232 targeting domain

<400>  831
gtgggggcct ctcctaggag cc                                                22


<210>  832
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-233 targeting domain

<400>  832
gatggcatgg ttctccccga ag                                                22


<210>  833
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-234 targeting domain

<400>  833
cgtcgcattg gagaagggca cg                                                22


<210>  834
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-235 targeting domain

<400>  834
tgggtggggt gtgcaggagc cc                                                22


<210>  835
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-236 targeting domain

<400>  835
ctggacggtg acgtagagcg tg                                                22


<210>  836
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-237 targeting domain

<400>  836
gaggaaaact gaggcaggga ga                                                22


<210>  837
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-238 targeting domain

<400>  837
ctgaacactg ccttgatctt at                                                22


<210>  838
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-239 targeting domain

<400>  838
cattacctgg accagccggc ga                                                22


<210>  839
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-240 targeting domain

<400>  839
ggagagagct tggtgctggg ag                                                22


<210>  840
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-241 targeting domain

<400>  840
agaataatgt cttgcattta ac                                                22


<210>  841
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-242 targeting domain

<400>  841
ctaggaaggc aaccaggagt gg                                                22


<210>  842
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-243 targeting domain

<400>  842
tctcccagac ccctccatgc tc                                                22


<210>  843
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-244 targeting domain

<400>  843
acaggggctg agaggggagg ca                                                22


<210>  844
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-245 targeting domain

<400>  844
ggggcagagg gaccacacgc tg                                                22


<210>  845
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-246 targeting domain

<400>  845
aggggaggca gaggatgcca ga                                                22


<210>  846
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-247 targeting domain

<400>  846
tggtccaggt aatggcactg ag                                                22


<210>  847
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-248 targeting domain

<400>  847
ccggacatgt gggggcctct cc                                                22


<210>  848
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-249 targeting domain

<400>  848
gcaggccagc gccatgaccc ag                                                22


<210>  849
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-250 targeting domain

<400>  849
ctagctaccc tctccctgtc ta                                                22


<210>  850
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-251 targeting domain

<400>  850
gctttggata acattgacag ga                                                22


<210>  851
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-252 targeting domain

<400>  851
gccattgcaa agctgggtga cg                                                22


<210>  852
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-253 targeting domain

<400>  852
cctaggtctc ctggctgtga tc                                                22


<210>  853
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-254 targeting domain

<400>  853
aacagagagg aaaactgagg ca                                                22


<210>  854
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-255 targeting domain

<400>  854
attacctgga ccagccggcg ag                                                22


<210>  855
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-256 targeting domain

<400>  855
gaggggcacc tgaggacagg gg                                                22


<210>  856
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-257 targeting domain

<400>  856
gggttatttc atttcccgag aa                                                22


<210>  857
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-258 targeting domain

<400>  857
agggtgcact cccccctaga ca                                                22


<210>  858
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-259 targeting domain

<400>  858
ccaggagtgg gagagggatt tg                                                22


<210>  859
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-260 targeting domain

<400>  859
agaggggagg cagaggatgc ca                                                22


<210>  860
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-261 targeting domain

<400>  860
ccgcctgctg actgccttgc ag                                                22


<210>  861
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-262 targeting domain

<400>  861
ggcttggtgc tgcaaacatg gc                                                22


<210>  862
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-263 targeting domain

<400>  862
caggtaatgg cactgagcag aa                                                22


<210>  863
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-264 targeting domain

<400>  863
ttggaacgcg gcagggaggc tg                                                22


<210>  864
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-265 targeting domain

<400>  864
tgtccgggtt atttcatttc cc                                                22


<210>  865
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-266 targeting domain

<400>  865
caggtagtac tgtgggtact cg                                                22


<210>  866
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-267 targeting domain

<400>  866
ataacagatc ccacttaaca ga                                                22


<210>  867
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-268 targeting domain

<400>  867
agggacgggt gcagagttga gt                                                22


<210>  868
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-269 targeting domain

<400>  868
gaaggagaga gcttggtgct gg                                                22


<210>  869
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-270 targeting domain

<400>  869
ggtcagccac ggctaggttg ag                                                22


<210>  870
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-271 targeting domain

<400>  870
atttcacagc aagaaaactg ag                                                22


<210>  871
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-272 targeting domain

<400>  871
tcaaagaagt caagcgccct gc                                                22


<210>  872
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-273 targeting domain

<400>  872
gctgctccca cccaagaatg ct                                                22


<210>  873
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-274 targeting domain

<400>  873
gcaacaaaca cccaacaatg gc                                                22


<210>  874
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-275 targeting domain

<400>  874
aaatccactt cccaccctga gc                                                22


<210>  875
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-276 targeting domain

<400>  875
cagggaggct ggaggggcac ct                                                22


<210>  876
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-277 targeting domain

<400>  876
gggcaagcca gacccctcct ct                                                22


<210>  877
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-278 targeting domain

<400>  877
caggaaaaca gatggggtgc tg                                                22


<210>  878
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-279 targeting domain

<400>  878
ttggagaagg gcacgtagaa gt                                                22


<210>  879
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-280 targeting domain

<400>  879
agagcttggt gctgggagga gg                                                22


<210>  880
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-281 targeting domain

<400>  880
tagctaggaa ggcaaccagg ag                                                22


<210>  881
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-282 targeting domain

<400>  881
ggctaggttg agcaggatgt ag                                                22


<210>  882
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-283 targeting domain

<400>  882
ctcaccaccc catgaagttc ca                                                22


<210>  883
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-284 targeting domain

<400>  883
aagcaatgtg caatgttttg cc                                                22


<210>  884
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-285 targeting domain

<400>  884
ggaagaccca atgactggag aa                                                22


<210>  885
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-286 targeting domain

<400>  885
tggccaggac caccaaggac ca                                                22


<210>  886
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-287 targeting domain

<400>  886
aaatattgtc cctttcactg tt                                                22


<210>  887
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-288 targeting domain

<400>  887
catgagcaac ttccgcttcg gg                                                22


<210>  888
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-289 targeting domain

<400>  888
agagatattc ctggatcaca gc                                                22


<210>  889
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-290 targeting domain

<400>  889
catggagggg tctgggagag tc                                                22


<210>  890
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-291 targeting domain

<400>  890
atgttttgcc cagaggaaga ag                                                22


<210>  891
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-292 targeting domain

<400>  891
gtgggtgggg tgtgcaggag cc                                                22


<210>  892
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-293 targeting domain

<400>  892
ccaggtaatg gcactgagca ga                                                22


<210>  893
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-294 targeting domain

<400>  893
cccaacaatg gccagagatt cc                                                22


<210>  894
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-295 targeting domain

<400>  894
gcacctgagg acaggggctg ag                                                22


<210>  895
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-296 targeting domain

<400>  895
gtcagaccca ggctgggcac tg                                                22


<210>  896
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-297 targeting domain

<400>  896
ggggcacctg aggacagggg ct                                                22


<210>  897
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-298 targeting domain

<400>  897
agaggaaaac tgaggcaggg ag                                                22


<210>  898
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-299 targeting domain

<400>  898
agggataaca gatcccactt aa                                                22


<210>  899
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-300 targeting domain

<400>  899
cttggtgctg ggaggagggg ga                                                22


<210>  900
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-301 targeting domain

<400>  900
agagggtagc taggaaggca ac                                                22


<210>  901
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-302 targeting domain

<400>  901
ttgcacattg cttcatggct cc                                                22


<210>  902
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-303 targeting domain

<400>  902
gaccgagccc attgcccagc ac                                                22


<210>  903
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-304 targeting domain

<400>  903
tgaacactgc cttgatctta tt                                                22


<210>  904
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-305 targeting domain

<400>  904
ggtgcactcc cccctagaca gg                                                22


<210>  905
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-306 targeting domain

<400>  905
gcttggtgct gggaggaggg gg                                                22


<210>  906
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-307 targeting domain

<400>  906
ggatacttcg tcttcgggcc ca                                                22


<210>  907
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-308 targeting domain

<400>  907
agtcagaccc aggctgggca ct                                                22


<210>  908
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-309 targeting domain

<400>  908
agcaccaagc ctctgtttcc ct                                                22


<210>  909
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-310 targeting domain

<400>  909
tgggcaaaga aattccaggg aa                                                22


<210>  910
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-311 targeting domain

<400>  910
agagggattt gaggaggcct tg                                                22


<210>  911
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-312 targeting domain

<400>  911
gcaatgtttt gcccagagga ag                                                22


<210>  912
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-313 targeting domain

<400>  912
catgtccggg ttatttcatt tc                                                22


<210>  913
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-314 targeting domain

<400>  913
aagcccatga gcaacttccg ct                                                22


<210>  914
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-315 targeting domain

<400>  914
tcccaccctg agcttgggcc cc                                                22


<210>  915
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-316 targeting domain

<400>  915
gagagagctt ggtgctggga gg                                                22


<210>  916
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-317 targeting domain

<400>  916
ctacgtgccc ttctccaatg cg                                                22


<210>  917
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-318 targeting domain

<400>  917
cttgcattta acaggaaaac ag                                                22


<210>  918
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-319 targeting domain

<400>  918
gaaatgaaat aacccggaca tg                                                22


<210>  919
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-320 targeting domain

<400>  919
cgaaggcctg agctcagcca ct                                                22


<210>  920
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-321 targeting domain

<400>  920
ggagggtgca ctccccccta ga                                                22


<210>  921
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-322 targeting domain

<400>  921
cagcaccaag cctctgtttc cc                                                22


<210>  922
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-323 targeting domain

<400>  922
gggcaaagaa attccaggga at                                                22


<210>  923
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-324 targeting domain

<400>  923
cttcggggag aaccatgcca tc                                                22


<210>  924
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-325 targeting domain

<400>  924
tgggaggagg gggaaggggc ag                                                22


<210>  925
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-326 targeting domain

<400>  925
cctagacagg gagagggtag ct                                                22


<210>  926
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-327 targeting domain

<400>  926
taacagagag gaaaactgag gc                                                22


<210>  927
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-328 targeting domain

<400>  927
tctcagccac caccgccaag cc                                                22


<210>  928
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-329 targeting domain

<400>  928
gtcagcacag accccactgc ct                                                22


<210>  929
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-330 targeting domain

<400>  929
aggaaaactg aggcagggag ag                                                22


<210>  930
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-331 targeting domain

<400>  930
agccattgca aagctgggtg ac                                                22


<210>  931
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-332 targeting domain

<400>  931
aaatgaaata acccggacat gt                                                22


<210>  932
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-333 targeting domain

<400>  932
tagctaccct ctccctgtct ag                                                22


<210>  933
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-334 targeting domain

<400>  933
tgtgggtggg gtgtgcagga gc                                                22


<210>  934
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-335 targeting domain

<400>  934
tggggaagga gagagcttgg tg                                                22


<210>  935
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-336 targeting domain

<400>  935
gacttggaac gcggcaggga gg                                                22


<210>  936
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-337 targeting domain

<400>  936
aaggagagag cttggtgctg gg                                                22


<210>  937
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-338 targeting domain

<400>  937
gggaaggaga gagcttggtg ct                                                22


<210>  938
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-339 targeting domain

<400>  938
atttgaggag gccttgggga ag                                                22


<210>  939
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-340 targeting domain

<400>  939
atccagctgg agccctgagt gg                                                22


<210>  940
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-341 targeting domain

<400>  940
gagagcttgg tgctgggagg ag                                                22


<210>  941
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-342 targeting domain

<400>  941
tcctagctac cctctccctg tc                                                22


<210>  942
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-343 targeting domain

<400>  942
ccgaggcagc agcctggaca tg                                                22


<210>  943
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-344 targeting domain

<400>  943
ggggaaggag agagcttggt gc                                                22


<210>  944
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-345 targeting domain

<400>  944
tgctgggagg agggggaagg gg                                                22


<210>  945
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-346 targeting domain

<400>  945
cttcttgtgc tggacggtga cg                                                22


<210>  946
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-347 targeting domain

<400>  946
taccacaccc gtcgcattgg ag                                                22


<210>  947
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-348 targeting domain

<400>  947
agcagcctgg acatggggga ga                                                22


<210>  948
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-349 targeting domain

<400>  948
agccaggtag tactgtgggt ac                                                22


<210>  949
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-350 targeting domain

<400>  949
ggctgcttgc ggttctcaac ac                                                22


<210>  950
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-351 targeting domain

<400>  950
ggaccgaggc agcagcctgg ac                                                22


<210>  951
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-352 targeting domain

<400>  951
ctgggcaaag aaattccagg ga                                                22


<210>  952
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-353 targeting domain

<400>  952
tgagagggga ggcagaggat gc                                                22


<210>  953
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-354 targeting domain

<400>  953
gagggtgcac tcccccctag ac                                                22


<210>  954
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-355 targeting domain

<400>  954
cggttctcaa caccaggaga ct                                                22


<210>  955
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-356 targeting domain

<400>  955
tgtgcaatgt tttgcccaga gg                                                22


<210>  956
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-357 targeting domain

<400>  956
gggggagaca gggcaaggct gg                                                22


<210>  957
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-358 targeting domain

<400>  957
gccgggtgtg ggtggggtgt gc                                                22


<210>  958
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-359 targeting domain

<400>  958
ctgcgtacca cacccgtcgc at                                                22


<210>  959
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-360 targeting domain

<400>  959
cacccaagaa tgctgcgaag gc                                                22


<210>  960
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-361 targeting domain

<400>  960
cctagctacc ctctccctgt ct                                                22


<210>  961
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-362 targeting domain

<400>  961
caccaggaga cttggaacgc gg                                                22


<210>  962
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-363 targeting domain

<400>  962
ttggataaca ttgacaggac ag                                                22


<210>  963
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-364 targeting domain

<400>  963
ttcgggccca caggatgcaa tt                                                22


<210>  964
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-365 targeting domain

<400>  964
gaagtatcca tgcagagagg tg                                                22


<210>  965
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-366 targeting domain

<400>  965
ggtgtgcagg agcccgggag ca                                                22


<210>  966
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-367 targeting domain

<400>  966
ggagcagcca cgggtcagcc ac                                                22


<210>  967
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-368 targeting domain

<400>  967
agcgccctgc tggggcgtca ca                                                22


<210>  968
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-369 targeting domain

<400>  968
gagcccggga gcatggaggg gt                                                22


<210>  969
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-370 targeting domain

<400>  969
agggccacag ccatgaatgg ca                                                22


<210>  970
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-371 targeting domain

<400>  970
gcaatgtgca atgttttgcc ca                                                22


<210>  971
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-372 targeting domain

<400>  971
gaagaggtca gccacggcta gg                                                22


<210>  972
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-373 targeting domain

<400>  972
ggccttcgca gcattcttgg gt                                                22


<210>  973
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-374 targeting domain

<400>  973
ttaacagaga ggaaaactga gg                                                22


<210>  974
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-375 targeting domain

<400>  974
tgatggcatg gttctccccg aa                                                22


<210>  975
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-376 targeting domain

<400>  975
accgaggcag cagcctggac at                                                22


<210>  976
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-377 targeting domain

<400>  976
agggaccaca cgctgaggag ag                                                22


<210>  977
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-378 targeting domain

<400>  977
tggaacgcgg cagggaggct gg                                                22


<210>  978
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-379 targeting domain

<400>  978
tgcacattgc ttcatggctc ct                                                22


<210>  979
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-380 targeting domain

<400>  979
gcgttccaag tctcctggtg tt                                                22


<210>  980
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-381 targeting domain

<400>  980
gggtgtgcag gagcccggga gc                                                22


<210>  981
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-382 targeting domain

<400>  981
ggcaaagaaa ttccagggaa tg                                                22


<210>  982
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-383 targeting domain

<400>  982
ggctggaggg gcacctgagg ac                                                22


<210>  983
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-384 targeting domain

<400>  983
gcgccctgct ggggcgtcac ac                                                22


<210>  984
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-385 targeting domain

<400>  984
gcgtaccaca cccgtcgcat tg                                                22


<210>  985
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-386 targeting domain

<400>  985
accaggagac ttggaacgcg gc                                                22


<210>  986
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-387 targeting domain

<400>  986
gctgctgcct cggtcccatt ct                                                22


<210>  987
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-388 targeting domain

<400>  987
gaagccctcc aaattgcatc ct                                                22


<210>  988
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-389 targeting domain

<400>  988
cgtagagcgt gaggaagttg at                                                22


<210>  989
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-390 targeting domain

<400>  989
ctgaagcagt tcctttttgc tt                                                22


<210>  990
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-391 targeting domain

<400>  990
gctggacggt gacgtagagc gt                                                22


<210>  991
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-392 targeting domain

<400>  991
tgagggcttt ggataacatt ga                                                22


<210>  992
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-393 targeting domain

<400>  992
agccgggtgt gggtggggtg tg                                                22


<210>  993
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-394 targeting domain

<400>  993
ctcagttttc ctctctgtta ag                                                22


<210>  994
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-395 targeting domain

<400>  994
caagacatta ttctaaagca aa                                                22


<210>  995
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-396 targeting domain

<400>  995
tggaacttca tggggtggtg ag                                                22


<210>  996
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-397 targeting domain

<400>  996
gagagggatt tgaggaggcc tt                                                22


<210>  997
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-398 targeting domain

<400>  997
cttcgggccc acaggatgca at                                                22


<210>  998
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-399 targeting domain

<400>  998
acttggaacg cggcagggag gc                                                22


<210>  999
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-400 targeting domain

<400>  999
atggccagag attccctgag aa                                                22


<210>  1000
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-401 targeting domain

<400>  1000
cctcagtttt cctctctgtt aa                                                22


<210>  1001
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-402 targeting domain

<400>  1001
taacagatcc cacttaacag ag                                                22


<210>  1002
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-403 targeting domain

<400>  1002
gggagaggga tttgaggagg cc                                                22


