                         SEQUENCE LISTING

<110>  RGENIX, INC.
 
<120>  High-Affinity Anti-MERTK Antibodies and Uses Thereof

<130>  13256-008-228

<140>
<141>

<150>  US 62/810,841
<151>  2019-02-26

<160>  132   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR1 (Kabat)

<400>  1

Asn Tyr Gly Met Asn 
1               5   


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR1 (Chothia)

<400>  2

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR1 (AbM/Exemplary)

<400>  3

Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR1 (Contact)

<400>  4

Thr Asn Tyr Gly Met Asn 
1               5       


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR1 (IMGT)

<400>  5

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR2 (Kabat/Exemplary)

<400>  6

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR2 (Chothia)

<400>  7

Thr Tyr Thr Gly 
1               


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR2 (AbM)

<400>  8

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
1               5                   10  


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR2 (Contact)

<400>  9

Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
1               5                   10              


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR2 (IMGT)

<400>  10

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR3 (Kabat/AbM/Exemplary)

<400>  11

Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val 
1               5                   10      


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR3 (Chothia)

<400>  12

Ser Thr Val Val Ser Arg Tyr Phe Asp 
1               5                   


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR3 (Contact)

<400>  13

Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp 
1               5                   10          


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VH CDR3 (IMGT)

<400>  14

Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val 
1               5                   10              


<210>  15
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/Z11/z13 VH Framework Region VH FR1 (Kabat)

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR2 (Kabat)

<400>  16

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  17
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10 VH Framework Region VH FR3 (Kabat/Exemplary)

<400>  17

Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR4 (Kabat)

<400>  18

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  19
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR1 (Chothia)

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR2 (Chothia)

<400>  20

Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
1               5                   10                  15      


Gly Trp Ile Asn 
            20  


<210>  21
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10 VH Framework Region VH FR3 (Chothia)

<400>  21

Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Phe Thr Thr 
1               5                   10                  15      


Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser 
            20                  25                  30          


Asp Asp Met Ala Val Tyr Tyr Cys Ala Arg Lys 
        35                  40              


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR4 (Chothia)

<400>  22

Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10          


<210>  23
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR1 (AbM)

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR2 (AbM)

<400>  24

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  25
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10 VH Framework Region VH FR3 (AbM)

<400>  25

Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser 
1               5                   10                  15      


Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Arg 
        35                  


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR4 (AbM)

<400>  26

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  27
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR1 (Contact)

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
            20                  25                  


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR2 (Contact)

<400>  28

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
1               5                   10      


<210>  29
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10 VH Framework Region VH FR3 (Contact)

<400>  29

Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser 
1               5                   10                  15      


Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR4 (Contact)

<400>  30

Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10          


<210>  31
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR1 (IMGT)

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR2 (IMGT)

<400>  32

Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  33
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10 VH Framework Region VH FR3 (IMGT)

<400>  33

Thr Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Phe Thr Thr Asp Thr 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            20                  25                  30          


Met Ala Val Tyr Tyr Cys 
        35              


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR4 (IMGT)

<400>  34

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  35
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR1 (Exemplary)

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  36
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR2 (Exemplary)

<400>  36

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VH Framework Region VH FR4 (Exemplary)

<400>  37

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  38
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z11 VH Framework Region VH FR3 (Kabat/Exemplary)

<400>  38

Arg Val Thr Met Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  39
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z11 VH Framework Region VH FR3 (Chothia)

<400>  39

Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Leu 
1               5                   10                  15      


Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser 
            20                  25                  30          


Asp Asp Met Ala Val Tyr Tyr Cys Ala Arg Lys 
        35                  40              


<210>  40
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z11 VH Framework Region VH FR3 (AbM)

<400>  40

Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Leu Asp Thr Ser 
1               5                   10                  15      


Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Arg 
        35                  


<210>  41
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z11 VH Framework Region VH FR3 (Contact)

<400>  41

Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Leu Asp Thr Ser 
1               5                   10                  15      


Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  42
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z11 VH Framework Region VH FR3 (IMGT)

<400>  42

Thr Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Leu Asp Thr 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            20                  25                  30          


Met Ala Val Tyr Tyr Cys 
        35              


<210>  43
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z13 VH Framework Region VH FR3 (Kabat/Exemplary)

<400>  43

Arg Val Thr Phe Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  44
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z13 VH Framework Region VH FR3 (Chothia)

<400>  44

Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Phe Thr Leu 
1               5                   10                  15      


Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser 
            20                  25                  30          


Asp Asp Met Ala Val Tyr Tyr Cys Ala Arg Lys 
        35                  40              


<210>  45
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z13 VH Framework Region VH FR3 (AbM)

<400>  45

Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Phe Thr Leu Asp Thr Ser 
1               5                   10                  15      


Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Arg 
        35                  


<210>  46
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z13 VH Framework Region VH FR3 (Contact)

<400>  46

Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Phe Thr Leu Asp Thr Ser 
1               5                   10                  15      


Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  47
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z13 VH Framework Region VH FR3 (IMGT)

<400>  47

Thr Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Phe Thr Leu Asp Thr 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            20                  25                  30          


Met Ala Val Tyr Tyr Cys 
        35              


<210>  48
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody VH FR3 Consensus sequence (Kabat)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = Phe or Met

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Thr or Leu

<400>  48

Arg Val Thr Xaa Thr Xaa Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  49
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody VH FR3 Consensus sequence (Chothia)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = Phe or Met

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = Thr or Leu

<400>  49

Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Xaa Thr Xaa 
1               5                   10                  15      


Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser 
            20                  25                  30          


Asp Asp Met Ala Val Tyr Tyr Cys Ala Arg Lys 
        35                  40              


<210>  50
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody VH FR3 Consensus sequence (AbM)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Phe or Met

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Thr or Leu

<400>  50

Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Xaa Thr Xaa Asp Thr Ser 
1               5                   10                  15      


Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Arg 
        35                  


<210>  51
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody VH FR3 Consensus sequence (Contact)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Phe or Met

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Thr or Leu

<400>  51

Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Xaa Thr Xaa Asp Thr Ser 
1               5                   10                  15      


Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  52
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody VH FR3 Consensus sequence (IMGT)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = Phe or Met

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = Thr or Leu

<400>  52

Thr Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Xaa Thr Xaa Asp Thr 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            20                  25                  30          


Met Ala Val Tyr Tyr Cys 
        35              


<210>  53
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody VH FR3 Consensus sequence (Exemplary)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = Phe or Met

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Thr or Leu

<400>  53

Arg Val Thr Xaa Thr Xaa Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  54
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR1 (Kabat)

<400>  54

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR2 (Kabat/AbM/Exemplary)

<400>  55

Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
1               5                   10                  


<210>  56
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR3 (Kabat/Exemplary)

<400>  56

Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR4 
(Kabat/AbM/IMGT/Exemplary)

<400>  57

Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  58
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR1 
(Chothia/AbM/IMGT/Exemplary)

<400>  58

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  59
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR2 (Chothia)

<400>  59

Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
1               5                   10                  15      


Gly Trp Ile Asn 
            20  


<210>  60
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR3 (Chothia)

<400>  60

Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Val Phe Ser Leu 
1               5                   10                  15      


Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn 
            20                  25                  30          


Glu Asp Met Ala Thr Tyr Phe Cys Ala Arg Lys 
        35                  40              


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR4 (Chothia/Contact)

<400>  61

Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10          


<210>  62
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR3 (AbM)

<400>  62

Tyr Ala Asp Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser 
1               5                   10                  15      


Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met 
            20                  25                  30          


Ala Thr Tyr Phe Cys Ala Arg 
        35                  


<210>  63
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR1 (Contact)

<400>  63

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
            20                  25                  


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR2 (Contact)

<400>  64

Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys 
1               5                   10      


<210>  65
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR3 (Contact)

<400>  65

Tyr Ala Asp Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser 
1               5                   10                  15      


Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met 
            20                  25                  30          


Ala Thr Tyr Phe Cys 
        35          


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR2 (IMGT)

<400>  66

Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  67
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VH Framework Region VH FR3 (IMGT)

<400>  67

Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Glu Thr 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            20                  25                  30          


Met Ala Thr Tyr Phe Cys 
        35              


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VL CDR1 (Kabat/AbM/Exemplary)

<400>  68

Lys Ala Ser Gln Asp Val Gly Asp Ala Val Thr 
1               5                   10      


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VL CDR2 (Kabat/AbM/Exemplary)

<400>  69

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VL CDR3 (Kabat/AbM/IMGT/Exemplary)

<400>  70

Gln Gln Tyr Arg Ser Tyr Pro Leu Thr 
1               5                   


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VL CDR1 (Chothia)

<400>  71

Ser Gln Asp Val Gly Asp Ala 
1               5           


<210>  72
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VL CDR2 (Chothia/IMGT)

<400>  72

Trp Ala Ser 
1           


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VL CDR3 (Chothia)

<400>  73

Tyr Arg Ser Tyr Pro Leu 
1               5       


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL CDR1 (Contact)

<400>  74

Gly Asp Ala Val Thr Trp Tyr 
1               5           


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VL CDR2 (Contact)

<400>  75

Leu Leu Ile Tyr Trp Ala Ser Thr Arg His 
1               5                   10  


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VL CDR3 (Contact)

<400>  76

Gln Gln Tyr Arg Ser Tyr Pro Leu 
1               5               


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13/xAb VL CDR1 (IMGT)

<400>  77

Gln Asp Val Gly Asp Ala 
1               5       


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL CDR1 (Contact)

<400>  78

Gly Asp Ala Val Thr Trp Cys 
1               5           


<210>  79
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR1 
(Kabat/AbM/Exemplary)

<400>  79

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR2 
(Kabat/AbM/Exemplary)

<400>  80

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  81
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR3 
(Kabat/AbM/Exemplary)

<400>  81

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR4 
(Kabat/AbM/IMGT/Exemplary)

<400>  82

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  83
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR1 (Chothia)

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala 
            20                  25  


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR2 (Chothia/IMGT)

<400>  84

Val Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  85
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR3 (Chothia)

<400>  85

Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys Gln Gln 
        35              


<210>  86
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR4 (Chothia/Contact)

<400>  86

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10      


<210>  87
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR1 (Contact)

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 
            20                  25                  


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR2 (Contact)

<400>  88

Gln Gln Lys Pro Gly Lys Ala Pro Lys 
1               5                   


<210>  89
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR3 (Contact)

<400>  89

Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
1               5                   10                  15      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            20                  25                  30          


Cys 
    


<210>  90
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR1 (IMGT)

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  91
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 VL Framework Region VL FR3 (IMGT)

<400>  91

Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  92
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR1 (Kabat/AbM/Exemplary)

<400>  92

Asp Ile Val Leu Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys 
            20              


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR2 (Kabat/AbM/Exemplary)

<400>  93

Trp Cys Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  94
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR3 (Kabat/AbM/Exemplary)

<400>  94

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Asn Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys 
            20                  25                  30          


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR4 (Kabat/AbM/IMGT/Exemplary)

<400>  95

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  96
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR1 (Chothia)

<400>  96

Asp Ile Val Leu Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala 
            20                  25  


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR2 (Chothia/IMGT)

<400>  97

Val Thr Trp Cys Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  98
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR3 (Chothia)

<400>  98

Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser Glu Asp Leu Ala 
            20                  25                  30          


Asp Tyr Phe Cys Gln Gln 
        35              


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR4 (Chothia/Contact)

<400>  99

Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10      


<210>  100
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR1 (Contact)

<400>  100

Asp Ile Val Leu Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val 
            20                  25                  


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR2 (Contact)

<400>  101

Gln Gln Lys Pro Gly Gln Pro Pro Lys 
1               5                   


<210>  102
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR3 (Contact)

<400>  102

Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
1               5                   10                  15      


Thr Leu Thr Ile Asn Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe 
            20                  25                  30          


Cys 
    


<210>  103
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR1 (IMGT)

<400>  103

Asp Ile Val Leu Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  104
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb VL Framework Region VL FR3 (IMGT)

<400>  104

Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser Glu Asp Leu Ala 
            20                  25                  30          


Asp Tyr Phe Cys 
        35      


<210>  105
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10 Heavy Chain Variable Region (VH)

<400>  105

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  106
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 light Chain Variable Region (VL)

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Asp Ala 
            20                  25                  30          


Val Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  107
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z11 Heavy Chain Variable Region (VH)

<400>  107

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  108
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z13 Heavy Chain Variable Region (VH)

<400>  108

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  109
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Heavy Chain Variable Region Consensus sequence

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa = Phe or Met

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa =  Thr or Leu

<400>  109

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Xaa Thr Xaa Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  110
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb Heavy Chain Variable Region (VH)

<400>  110

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  111
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb Light Chain Variable Region (VL)

<400>  111

Asp Ile Val Leu Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Asp Ala 
            20                  25                  30          


Val Thr Trp Cys Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  112
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10 Heavy Chain 

<400>  112

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  113
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 Light Chain

<400>  113

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Asp Ala 
            20                  25                  30          


Val Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  114
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z11 Heavy Chain

<400>  114

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  115
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody z13 Heavy Chain

<400>  115

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  116
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Heavy Chain Consensus Sequences

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa = Phe or Met

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = Thr or Leu

<400>  116

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Xaa Thr Xaa Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  117
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb Heavy Chain

<400>  117

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  118
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody xAb Light Chain

<400>  118

Asp Ile Val Leu Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Asp Ala 
            20                  25                  30          


Val Thr Trp Cys Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  119
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody z10 Variable Region VH DNA Sequences

<400>  119
caggtgcagc tggtgcagag cggcgctgag gtgaagaagc ccggcgctag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc aactacggca tgaactgggt gaggcaggct      120

cctggacagg gcctggagtg gatgggctgg atcaacacat acaccggcga gcccacctac      180

gccgacgact tcaagggcag ggtgaccttt accaccgaca ccagcaccag caccgcctac      240

atggagctga ggagcctgag aagcgacgac atggccgtgt actactgcgc cagaaagagc      300

accgtggtgt ccaggtactt cgacgtgtgg ggccagggca ccacagtgac cgtgagcagc      360


<210>  120
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 Variable Region VL DNA Sequences

<400>  120
gacatccaga tgacccagag ccccagcttc ctgtccgcta gcgtgggcga cagggtgacc       60

atcacctgca aggccagcca ggacgtgggc gatgccgtga cctggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactgg gccagcacaa ggcacacagg cgtgcccgac      180

agattcagcg gcagcggaag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacaggagct accccctgac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  121
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody z11 Variable Region VH DNA Sequences

<400>  121
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggcgccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc aactacggca tgaactgggt gaggcaggct      120

cctggccagg gactggagtg gatgggctgg atcaacacct acaccggcga gcccacctac      180

gccgacgact tcaagggcag ggtgaccatg accctggaca ccagcaccag caccgcctac      240

atggagctga ggagcctgag gagcgacgac atggccgtgt actactgcgc caggaagagc      300

accgtggtgt ccaggtactt cgacgtgtgg ggacagggca ccaccgtgac cgtgagcagc      360


<210>  122
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody z13 Variable Region VH DNA Sequences

<400>  122
caggtgcagc tggtgcagag cggagccgaa gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc aactacggca tgaactgggt gagacaggcc      120

cctggacagg gactggagtg gatgggctgg atcaacacct acaccggcga gcccacctac      180

gccgacgact tcaagggcag ggtgaccttc accctggaca ccagcaccag caccgcctac      240

atggagctga ggagcctgag gagcgacgac atggccgtgt actattgcgc caggaagagc      300

accgtggtga gcaggtactt cgacgtgtgg ggccagggaa ccaccgtgac cgtgagcagc      360


<210>  123
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody xAb Variable Region VH DNA Sequences

<400>  123
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggata taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgtcttc tctttggaaa cctctgccag cactgcctac      240

ttgcagatca acaacctcaa aaatgaggac atggccacat atttctgtgc aagaaaaagt      300

acggtagtaa gtaggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360


<210>  124
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody xAb Variable Region VL DNA Sequences

<400>  124
gacattgtgc tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgggt gatgctgtaa cctggtgtca acagaaacca      120

ggtcaacctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtgggtc tgggacagat ttcactctca ccattaacaa tgtgcagtct      240

gaggacttgg cagattattt ctgtcagcaa tatcgcagct atcctctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  125
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody z10 Heavy Chain DNA Sequences

<400>  125
caggtgcagc tggtgcagag cggcgctgag gtgaagaagc ccggcgctag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc aactacggca tgaactgggt gaggcaggct      120

cctggacagg gcctggagtg gatgggctgg atcaacacat acaccggcga gcccacctac      180

gccgacgact tcaagggcag ggtgaccttt accaccgaca ccagcaccag caccgcctac      240

atggagctga ggagcctgag aagcgacgac atggccgtgt actactgcgc cagaaagagc      300

accgtggtgt ccaggtactt cgacgtgtgg ggccagggca ccacagtgac cgtgagcagc      360

gcgtcgacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcc      480

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtctacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagct taagcctgtc tccgggtaaa tga                                  1353


<210>  126
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody z10/z11/z13 Light Chain DNA Sequences

<400>  126
gacatccaga tgacccagag ccccagcttc ctgtccgcta gcgtgggcga cagggtgacc       60

atcacctgca aggccagcca ggacgtgggc gatgccgtga cctggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactgg gccagcacaa ggcacacagg cgtgcccgac      180

agattcagcg gcagcggaag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacaggagct accccctgac cttcggccag      300

ggcaccaagc tggaaatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      645


<210>  127
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody z11 Heavy Chain DNA Sequences

<400>  127
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggcgccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc aactacggca tgaactgggt gaggcaggct      120

cctggccagg gactggagtg gatgggctgg atcaacacct acaccggcga gcccacctac      180

gccgacgact tcaagggcag ggtgaccatg accctggaca ccagcaccag caccgcctac      240

atggagctga ggagcctgag gagcgacgac atggccgtgt actactgcgc caggaagagc      300

accgtggtgt ccaggtactt cgacgtgtgg ggacagggca ccaccgtgac cgtgagcagc      360

gcgtcgacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcc      480

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtctacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagct taagcctgtc tccgggtaaa tga                                  1353


<210>  128
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody z13 Heavy Chain DNA Sequences

<400>  128
caggtgcagc tggtgcagag cggagccgaa gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc aactacggca tgaactgggt gagacaggcc      120

cctggacagg gactggagtg gatgggctgg atcaacacct acaccggcga gcccacctac      180

gccgacgact tcaagggcag ggtgaccttc accctggaca ccagcaccag caccgcctac      240

atggagctga ggagcctgag gagcgacgac atggccgtgt actattgcgc caggaagagc      300

accgtggtga gcaggtactt cgacgtgtgg ggccagggaa ccaccgtgac cgtgagcagc      360

gcgtcgacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcc      480

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtctacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagct taagcctgtc tccgggtaaa tga                                  1353


<210>  129
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody xAb Heavy Chain DNA Sequences

<400>  129
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggata taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgtcttc tctttggaaa cctctgccag cactgcctac      240

ttgcagatca acaacctcaa aaatgaggac atggccacat atttctgtgc aagaaaaagt      300

acggtagtaa gtaggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360

gcgtcgacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcc      480

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtctacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagct taagcctgtc tccgggtaaa tga                                  1353


<210>  130
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody xAb Light Chain DNA Sequences

<400>  130
gacattgtgc tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgggt gatgctgtaa cctggtgtca acagaaacca      120

ggtcaacctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtgggtc tgggacagat ttcactctca ccattaacaa tgtgcagtct      240

gaggacttgg cagattattt ctgtcagcaa tatcgcagct atcctctcac gttcggtgct      300

gggaccaagc tggagctgaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      645


<210>  131
<211>  999
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Full-Length Human MERTK (Swiss-Prot ID: Q12866.2)

<400>  131

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  


Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  


Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      


Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         


Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             


Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 


Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 


Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     


Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         


Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             


Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 


Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 


Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     


Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         


Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             


Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 


Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 


Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     


Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         


Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             


Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 


Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 


Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     


Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         


Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             


Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 


Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 


Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     


Gly Asn Ala Asp Pro Val Leu Ile Ile Phe Gly Cys Phe Cys Gly Phe 
            500                 505                 510         


Ile Leu Ile Gly Leu Ile Leu Tyr Ile Ser Leu Ala Ile Arg Lys Arg 
        515                 520                 525             


Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu 
    530                 535                 540                 


Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile 
545                 550                 555                 560 


Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys 
                565                 570                 575     


Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile 
            580                 585                 590         


Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln 
        595                 600                 605             


Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp 
    610                 615                 620                 


Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys 
625                 630                 635                 640 


Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys 
                645                 650                 655     


Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro 
            660                 665                 670         


Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu 
        675                 680                 685             


Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met 
    690                 695                 700                 


Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu 
705                 710                 715                 720 


His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr 
                725                 730                 735     


Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        755                 760                 765             


Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    770                 775                 780                 


Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro 
785                 790                 795                 800 


Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly 
                805                 810                 815     


His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile 
            820                 825                 830         


Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser 
        835                 840                 845             


Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val 
    850                 855                 860                 


Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser 
865                 870                 875                 880 


Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn 
                885                 890                 895     


Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile 
            900                 905                 910         


Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg 
        915                 920                 925             


Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala 
    930                 935                 940                 


Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu 
945                 950                 955                 960 


Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro 
                965                 970                 975     


Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser 
            980                 985                 990         


Glu Gly Ser Glu Val Leu Met 
        995                 


<210>  132
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Doman of MERTK Used for Immunization

<400>  132

Arg Glu Glu Ala Lys Pro Tyr Pro Leu Phe Pro Gly Pro Phe Pro Gly 
1               5                   10                  15      


Ser Leu Gln Thr Asp His Thr Pro Leu Leu Ser Leu Pro His Ala Ser 
            20                  25                  30          


Gly Tyr Gln Pro Ala Leu Met Phe Ser Pro Thr Gln Pro Gly Arg Pro 
        35                  40                  45              


His Thr Gly Asn Val Ala Ile Pro Gln Val Thr Ser Val Glu Ser Lys 
    50                  55                  60                  


Pro Leu Pro Pro Leu Ala Phe Lys His Thr Val Gly His Ile Ile Leu 
65                  70                  75                  80  


Ser Glu His Lys Gly Val Lys Phe Asn Cys Ser Ile Ser Val Pro Asn 
                85                  90                  95      


Ile Tyr Gln Asp Thr Thr Ile Ser Trp Trp Lys Asp Gly Lys Glu Leu 
            100                 105                 110         


Leu Gly Ala His His Ala Ile Thr Gln Phe Tyr Pro Asp Asp Glu Val 
        115                 120                 125             


Thr Ala Ile Ile Ala Ser Phe Ser Ile Thr Ser Val Gln Arg Ser Asp 
    130                 135                 140                 


Asn Gly Ser Tyr Ile Cys Lys Met Lys Ile Asn Asn Glu Glu Ile Val 
145                 150                 155                 160 


Ser Asp Pro Ile Tyr Ile Glu Val Gln Gly Leu Pro His Phe Thr Lys 
                165                 170                 175     


Gln Pro Glu Ser Met Asn Val Thr Arg Asn Thr Ala Phe Asn Leu Thr 
            180                 185                 190         


Cys Gln Ala Val Gly Pro Pro Glu Pro Val Asn Ile Phe Trp Val Gln 
        195                 200                 205             


Asn Ser Ser Arg Val Asn Glu Gln Pro Glu Lys Ser Pro Ser Val Leu 
    210                 215                 220                 


Thr Val Pro Gly Leu Thr Glu Met Ala Val Phe Ser Cys Glu Ala His 
225                 230                 235                 240 


Asn Asp Lys Gly Leu Thr Val Ser Lys Gly Val Gln Ile Asn Ile Lys 
                245                 250                 255     


Ala Ile Pro Ser Pro Pro Thr Glu Val Ser Ile Arg Asn Ser Thr Ala 
            260                 265                 270         


His Ser Ile Leu Ile Ser Trp Val Pro Gly Phe Asp Gly Tyr Ser Pro 
        275                 280                 285             


Phe Arg Asn Cys Ser Ile Gln Val Lys Glu Ala Asp Pro Leu Ser Asn 
    290                 295                 300                 


Gly Ser Val Met Ile Phe Asn Thr Ser Ala Leu Pro His Leu Tyr Gln 
305                 310                 315                 320 


Ile Lys Gln Leu Gln Ala Leu Ala Asn Tyr Ser Ile Gly Val Ser Cys 
                325                 330                 335     


Met Asn Glu Ile Gly Trp Ser Ala Val Ser Pro Trp Ile Leu Ala Ser 
            340                 345                 350         


Thr Thr Glu Gly Ala Pro Ser Val Ala Pro Leu Asn Val Thr Val Phe 
        355                 360                 365             


Leu Asn Glu Ser Ser Asp Asn Val Asp Ile Arg Trp Met Lys Pro Pro 
    370                 375                 380                 


Thr Lys Gln Gln Asp Gly Glu Leu Val Gly Tyr Arg Ile Ser His Val 
385                 390                 395                 400 


Trp Gln Ser Ala Gly Ile Ser Lys Glu Leu Leu Glu Glu Val Gly Gln 
                405                 410                 415     


Asn Gly Ser Arg Ala Arg Ile Ser Val Gln Val His Asn Ala Thr Cys 
            420                 425                 430         


Thr Val Arg Ile Ala Ala Val Thr Arg Gly Gly Val Gly Pro Phe Ser 
        435                 440                 445             


Asp Pro Val Lys Ile Phe Ile Pro Ala His Gly Trp Val Asp Tyr Ala 
    450                 455                 460                 


Pro Ser Ser Thr Pro Ala Pro Gly Asn Ala 
465                 470                 


