                               SEQUENCE LISTING

<110> THE UNIVERSITY OF CHICAGO
 
<120> METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY AND AUTOIMMUNE
      CONDITIONS WITH ECM-AFFINITY PEPTIDES LINKED TO 
      ANTI-INFLAMMATORY AGENTS

<130> ARCD-P0679WO-1001110046

<140> PCT/US2020/019668
<141> 2020-02-25

<150> 62/809,988
<151> 2019-02-25

<160> 69    

<170> PatentIn version 3.5

<210> 1
<211> 10
<212> PRT
<213> Bos sp.

<400> 1
Leu Arg Glu Leu His Leu Asn Asn Asn Cys 
1               5                   10  


<210> 2
<211> 10
<212> PRT
<213> Homo sapiens

<400> 2
Leu Arg Glu Leu His Leu Asp Asn Asn Cys 
1               5                   10  


<210> 3
<211> 344
<212> PRT
<213> Homo sapiens

<400> 3
Cys Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp 
1               5                   10                  15      


Glu Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu 
            20                  25                  30          


Pro Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg 
        35                  40                  45              


Val Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu 
    50                  55                  60                  


Pro Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu 
65                  70                  75                  80  


Ile Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile 
                85                  90                  95      


Leu Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro 
            100                 105                 110         


Leu Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu 
        115                 120                 125             


Leu Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu 
    130                 135                 140                 


Asn Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln 
145                 150                 155                 160 


Met Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile 
                165                 170                 175     


Glu Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile 
            180                 185                 190         


Ala Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu 
        195                 200                 205             


Thr Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala 
    210                 215                 220                 


Ser Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn 
225                 230                 235                 240 


Ser Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu 
                245                 250                 255     


Arg Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly 
            260                 265                 270         


Leu Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn 
        275                 280                 285             


Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr 
    290                 295                 300                 


Lys Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln 
305                 310                 315                 320 


Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser 
                325                 330                 335     


Ala Ile Gln Leu Gly Asn Tyr Lys 
            340                 


<210> 4
<211> 222
<212> PRT
<213> Homo sapiens

<400> 4
Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro Val 
1               5                   10                  15      


Ser Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu His 
            20                  25                  30          


Asp Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly 
        35                  40                  45              


Ser Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val 
    50                  55                  60                  


Val Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val 
65                  70                  75                  80  


Ala Val Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys 
                85                  90                  95      


Asp Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys 
            100                 105                 110         


Tyr Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr 
        115                 120                 125             


Leu Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile 
    130                 135                 140                 


Thr Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn 
145                 150                 155                 160 


Phe Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile 
                165                 170                 175     


Pro Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile 
            180                 185                 190         


Glu Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp 
        195                 200                 205             


Glu Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys 
    210                 215                 220         


<210> 5
<211> 196
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      vWF A3 sequence

<400> 5
Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
        35                  40                  45              


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
    50                  55                  60                  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
                85                  90                  95      


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe Val Arg 
            180                 185                 190         


Ile Cys Thr Gly 
        195     


<210> 6
<211> 2813
<212> PRT
<213> Homo sapiens

<400> 6
Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Thr Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210> 7
<211> 205
<212> PRT
<213> Homo sapiens

<400> 7
Cys Ser Gly Glu Gly Leu Gln Ile Pro Thr Leu Ser Pro Ala Pro Asp 
1               5                   10                  15      


Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
            20                  25                  30          


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
        35                  40                  45              


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
    50                  55                  60                  


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
65                  70                  75                  80  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
                85                  90                  95      


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
            100                 105                 110         


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
        115                 120                 125             


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
    130                 135                 140                 


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
145                 150                 155                 160 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
                165                 170                 175     


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
            180                 185                 190         


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly 
        195                 200                 205 


<210> 8
<211> 170
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      PlGF-2 sequence

<400> 8
Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly 
            20                  25                  30          


Asn Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly 
        35                  40                  45              


Arg Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu 
    50                  55                  60                  


Tyr Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu 
65                  70                  75                  80  


Leu Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro 
                85                  90                  95      


Val Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly 
            100                 105                 110         


Asp Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys 
        115                 120                 125             


Glu Cys Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Arg Arg Pro 
    130                 135                 140                 


Lys Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg Pro Thr Asp Cys 
145                 150                 155                 160 


His Leu Cys Gly Asp Ala Val Pro Arg Arg 
                165                 170 


<210> 9
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      PlGF-2 sequence

<400> 9
Arg Arg Arg Pro Lys Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg 
1               5                   10                  15      


Pro Thr Asp Cys His Leu Cys Gly Asp Ala Val Pro Arg Arg 
            20                  25                  30  


<210> 10
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      PlGF-2 sequence

<400> 10
Arg Arg Arg Pro Lys Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg 
1               5                   10                  15      


Pro Thr Asp Cys His Leu 
            20          


<210> 11
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      PlGF-2 sequence

<400> 11
Arg Arg Pro Lys Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg Pro 
1               5                   10                  15      


Thr Asp 
        


<210> 12
<211> 15
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      PlGF-2 sequence

<400> 12
Arg Arg Arg Pro Lys Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln 
1               5                   10                  15  


<210> 13
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      PlGF-2 sequence

<400> 13
Gly Lys Arg Arg Arg Glu Lys Gln 
1               5               


<210> 14
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      PlGF-2 sequence

<400> 14
Arg Arg Arg Pro Lys Gly Arg Gly 
1               5               


<210> 15
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      PlGF-2 sequence

<400> 15
Arg Arg Lys Thr Lys Gly Lys Arg Lys Arg Ser Arg Asn Ser Gln Thr 
1               5                   10                  15      


Glu Glu Pro His Pro 
            20      


<210> 16
<211> 98
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CXCL-12gamma sequence

<400> 16
Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys Gly Arg Arg Glu Glu Lys Val Gly Lys Lys Glu Lys 
65                  70                  75                  80  


Ile Gly Lys Lys Lys Arg Gln Lys Lys Arg Lys Ala Ala Gln Lys Arg 
                85                  90                  95      


Lys Asn 
        


<210> 17
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CXCL-12gamma sequence

<400> 17
Gly Arg Arg Glu Glu Lys Val Gly Lys Lys Glu Lys Ile Gly Lys Lys 
1               5                   10                  15      


Lys Arg Gln Lys Lys Arg Lys Ala Ala Gln Lys Arg Lys Asn 
            20                  25                  30  


<210> 18
<211> 152
<212> PRT
<213> Homo sapiens

<400> 18
Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      


Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          


Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              


Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  


Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  


Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         


<210> 19
<211> 152
<212> PRT
<213> Mus sp.

<400> 19
Arg Pro Ser Gly Lys Arg Pro Cys Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      


Asp Thr Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Ile Ala 
            20                  25                  30          


Gly Tyr Leu Gln Gly Pro Asn Ile Lys Leu Glu Glu Lys Ile Asp Met 
        35                  40                  45              


Val Pro Ile Asp Leu His Ser Val Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  


Leu Cys Leu Ser Cys Ala Lys Ser Gly Asp Asp Ile Lys Leu Gln Leu 
65                  70                  75                  80  


Glu Glu Val Asn Ile Thr Asp Leu Ser Lys Asn Lys Glu Glu Asp Lys 
                85                  90                  95      


Arg Phe Thr Phe Ile Arg Ser Glu Lys Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Thr Leu Glu Ala Asp 
        115                 120                 125             


Arg Pro Val Ser Leu Thr Asn Thr Pro Glu Glu Pro Leu Ile Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp Gln 
145                 150         


<210> 20
<211> 129
<212> PRT
<213> Homo sapiens

<400> 20
His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210> 21
<211> 120
<212> PRT
<213> Mus sp.

<400> 21
His Ile His Gly Cys Asp Lys Asn His Leu Arg Glu Ile Ile Gly Ile 
1               5                   10                  15      


Leu Asn Glu Val Thr Gly Glu Gly Thr Pro Cys Thr Glu Met Asp Val 
            20                  25                  30          


Pro Asn Val Leu Thr Ala Thr Lys Asn Thr Thr Glu Ser Glu Leu Val 
        35                  40                  45              


Cys Arg Ala Ser Lys Val Leu Arg Ile Phe Tyr Leu Lys His Gly Lys 
    50                  55                  60                  


Thr Pro Cys Leu Lys Lys Asn Ser Ser Val Leu Met Glu Leu Gln Arg 
65                  70                  75                  80  


Leu Phe Arg Ala Phe Arg Cys Leu Asp Ser Ser Ile Ser Cys Thr Met 
                85                  90                  95      


Asn Glu Ser Lys Ser Thr Ser Leu Lys Asp Phe Leu Glu Ser Leu Lys 
            100                 105                 110         


Ser Ile Met Gln Met Asp Tyr Ser 
        115                 120 


<210> 22
<211> 115
<212> PRT
<213> Homo sapiens

<400> 22
Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu Thr Leu Ala 
1               5                   10                  15      


Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu Thr Leu Arg 
            20                  25                  30          


Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr Glu Glu Ile 
        35                  40                  45              


Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln Gly Gly Thr 
    50                  55                  60                  


Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys Tyr Ile Asp 
65                  70                  75                  80  


Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val Asn Gln Phe 
                85                  90                  95      


Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr Glu Trp Ile 
            100                 105                 110         


Ile Glu Ser 
        115 


<210> 23
<211> 112
<212> PRT
<213> Mus sp.

<400> 23
Glu Ile Pro Met Ser Thr Val Val Lys Glu Thr Leu Thr Gln Leu Ser 
1               5                   10                  15      


Ala His Arg Ala Leu Leu Thr Ser Asn Glu Thr Met Arg Leu Pro Val 
            20                  25                  30          


Pro Thr His Lys Asn His Gln Leu Cys Ile Gly Glu Ile Phe Gln Gly 
        35                  40                  45              


Leu Asp Ile Leu Lys Asn Gln Thr Val Arg Gly Gly Thr Val Glu Met 
    50                  55                  60                  


Leu Phe Gln Asn Leu Ser Leu Ile Lys Lys Tyr Ile Asp Arg Gln Lys 
65                  70                  75                  80  


Glu Lys Cys Gly Glu Glu Arg Arg Arg Thr Arg Gln Phe Leu Asp Tyr 
                85                  90                  95      


Leu Gln Glu Phe Leu Gly Val Met Ser Thr Glu Trp Ala Met Glu Gly 
            100                 105                 110         


<210> 24
<211> 160
<212> PRT
<213> Homo sapiens

<400> 24
Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210> 25
<211> 101
<212> PRT
<213> Mus sp.

<400> 25
Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu 
1               5                   10                  15      


Val Met Pro Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu 
            20                  25                  30          


Asn Ser Leu Gly Gln Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg 
        35                  40                  45              


Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln 
    50                  55                  60                  


Val Lys Ser Asp Phe Asn Lys Leu Glu Asp Gln Gly Val Tyr Lys Ala 
65                  70                  75                  80  


Met Asn Glu Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met 
                85                  90                  95      


Ile Lys Met Lys Ser 
            100     


<210> 26
<211> 178
<212> PRT
<213> Homo sapiens

<400> 26
Pro Gly Pro Pro Pro Gly Pro Pro Arg Val Ser Pro Asp Pro Arg Ala 
1               5                   10                  15      


Glu Leu Asp Ser Thr Val Leu Leu Thr Arg Ser Leu Leu Ala Asp Thr 
            20                  25                  30          


Arg Gln Leu Ala Ala Gln Leu Arg Asp Lys Phe Pro Ala Asp Gly Asp 
        35                  40                  45              


His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met Ser Ala Gly Ala Leu 
    50                  55                  60                  


Gly Ala Leu Gln Leu Pro Gly Val Leu Thr Arg Leu Arg Ala Asp Leu 
65                  70                  75                  80  


Leu Ser Tyr Leu Arg His Val Gln Trp Leu Arg Arg Ala Gly Gly Ser 
                85                  90                  95      


Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Thr Leu Gln Ala Arg Leu 
            100                 105                 110         


Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu Met Ser Arg Leu Ala Leu 
        115                 120                 125             


Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro Pro Leu Ala Pro Pro Ser 
    130                 135                 140                 


Ser Ala Trp Gly Gly Ile Arg Ala Ala His Ala Ile Leu Gly Gly Leu 
145                 150                 155                 160 


His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu Leu Leu Leu Lys Thr 
                165                 170                 175     


Arg Leu 
        


<210> 27
<211> 179
<212> PRT
<213> Mus sp.

<400> 27
Met Pro Gly Pro Pro Ala Gly Ser Pro Arg Val Ser Ser Asp Pro Arg 
1               5                   10                  15      


Ala Asp Leu Asp Ser Ala Val Leu Leu Thr Arg Ser Leu Leu Ala Asp 
            20                  25                  30          


Thr Arg Gln Leu Ala Ala Gln Met Arg Asp Lys Phe Pro Ala Asp Gly 
        35                  40                  45              


Asp His Ser Leu Asp Ser Leu Pro Thr Leu Ala Met Ser Ala Gly Thr 
    50                  55                  60                  


Leu Gly Ser Leu Gln Leu Pro Gly Val Leu Thr Arg Leu Arg Val Asp 
65                  70                  75                  80  


Leu Met Ser Tyr Leu Arg His Val Gln Trp Leu Arg Arg Ala Gly Gly 
                85                  90                  95      


Pro Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Ala Leu Gln Ala Arg 
            100                 105                 110         


Leu Glu Arg Leu Leu Arg Arg Leu Gln Leu Leu Met Ser Arg Leu Ala 
        115                 120                 125             


Leu Pro Gln Ala Ala Pro Asp Gln Pro Val Ile Pro Leu Gly Pro Pro 
    130                 135                 140                 


Ala Ser Ala Trp Gly Ser Ile Arg Ala Ala His Ala Ile Leu Gly Gly 
145                 150                 155                 160 


Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu Leu Leu Leu Lys 
                165                 170                 175     


Thr Arg Leu 
            


<210> 28
<211> 170
<212> PRT
<213> Homo sapiens

<400> 28
Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln Cys Gln Gln 
1               5                   10                  15      


Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His Pro Leu Val 
            20                  25                  30          


Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr Thr Asn Asp 
        35                  40                  45              


Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln Gly Leu Arg 
    50                  55                  60                  


Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly Leu Ile Phe 
65                  70                  75                  80  


Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu Pro Ser Leu 
                85                  90                  95      


Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu Leu Gly Leu 
            100                 105                 110         


Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr Gln Gln Ile 
        115                 120                 125             


Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu Leu Arg Phe 
    130                 135                 140                 


Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala Ala Arg Val 
145                 150                 155                 160 


Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
                165                 170 


<210> 29
<211> 306
<212> PRT
<213> Homo sapiens

<400> 29
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210> 30
<211> 197
<212> PRT
<213> Homo sapiens

<400> 30
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 31
<211> 209
<212> PRT
<213> Homo sapiens

<400> 31
Arg Lys Gly Pro Pro Ala Ala Leu Thr Leu Pro Arg Val Gln Cys Arg 
1               5                   10                  15      


Ala Ser Arg Tyr Pro Ile Ala Val Asp Cys Ser Trp Thr Leu Pro Pro 
            20                  25                  30          


Ala Pro Asn Ser Thr Ser Pro Val Ser Phe Ile Ala Thr Tyr Arg Leu 
        35                  40                  45              


Gly Met Ala Ala Arg Gly His Ser Trp Pro Cys Leu Gln Gln Thr Pro 
    50                  55                  60                  


Thr Ser Thr Ser Cys Thr Ile Thr Asp Val Gln Leu Phe Ser Met Ala 
65                  70                  75                  80  


Pro Tyr Val Leu Asn Val Thr Ala Val His Pro Trp Gly Ser Ser Ser 
                85                  90                  95      


Ser Phe Val Pro Phe Ile Thr Glu His Ile Ile Lys Pro Asp Pro Pro 
            100                 105                 110         


Glu Gly Val Arg Leu Ser Pro Leu Ala Glu Arg Gln Leu Gln Val Gln 
        115                 120                 125             


Trp Glu Pro Pro Gly Ser Trp Pro Phe Pro Glu Ile Phe Ser Leu Lys 
    130                 135                 140                 


Tyr Trp Ile Arg Tyr Lys Arg Gln Gly Ala Ala Arg Phe His Arg Val 
145                 150                 155                 160 


Gly Pro Ile Glu Ala Thr Ser Phe Ile Leu Arg Ala Val Arg Pro Arg 
                165                 170                 175     


Ala Arg Tyr Tyr Val Gln Val Ala Ala Gln Asp Leu Thr Asp Tyr Gly 
            180                 185                 190         


Glu Leu Ser Asp Trp Ser Leu Pro Ala Thr Ala Thr Met Ser Leu Gly 
        195                 200                 205             


Lys 
    


<210> 32
<211> 193
<212> PRT
<213> Mus sp.

<400> 32
Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala 
    


<210> 33
<211> 206
<212> PRT
<213> Mus sp.

<400> 33
Ala Leu Val Ala Leu Ser Gln Pro Arg Val Gln Cys His Ala Ser Arg 
1               5                   10                  15      


Tyr Pro Val Ala Val Asp Cys Ser Trp Thr Pro Leu Gln Ala Pro Asn 
            20                  25                  30          


Ser Thr Arg Ser Thr Ser Phe Ile Ala Thr Tyr Arg Leu Gly Val Ala 
        35                  40                  45              


Thr Gln Gln Gln Ser Gln Pro Cys Leu Gln Arg Ser Pro Gln Ala Ser 
    50                  55                  60                  


Arg Cys Thr Ile Pro Asp Val His Leu Phe Ser Thr Val Pro Tyr Met 
65                  70                  75                  80  


Leu Asn Val Thr Ala Val His Pro Gly Gly Ala Ser Ser Ser Leu Leu 
                85                  90                  95      


Ala Phe Val Ala Glu Arg Ile Ile Lys Pro Asp Pro Pro Glu Gly Val 
            100                 105                 110         


Arg Leu Arg Thr Ala Gly Gln Arg Leu Gln Val Leu Trp His Pro Pro 
        115                 120                 125             


Ala Ser Trp Pro Phe Pro Asp Ile Phe Ser Leu Lys Tyr Arg Leu Arg 
    130                 135                 140                 


Tyr Arg Arg Arg Gly Ala Ser His Phe Arg Gln Val Gly Pro Ile Glu 
145                 150                 155                 160 


Ala Thr Thr Phe Thr Leu Arg Asn Ser Lys Pro His Ala Lys Tyr Cys 
                165                 170                 175     


Ile Gln Val Ser Ala Gln Asp Leu Thr Asp Tyr Gly Lys Pro Ser Asp 
            180                 185                 190         


Trp Ser Leu Pro Gly Gln Val Glu Ser Ala Pro His Lys Pro 
        195                 200                 205     


<210> 34
<211> 154
<212> PRT
<213> Homo sapiens

<400> 34
Val Leu Ser Gly Ala Leu Cys Phe Arg Met Lys Asp Ser Ala Leu Lys 
1               5                   10                  15      


Val Leu Tyr Leu His Asn Asn Gln Leu Leu Ala Gly Gly Leu His Ala 
            20                  25                  30          


Gly Lys Val Ile Lys Gly Glu Glu Ile Ser Val Val Pro Asn Arg Trp 
        35                  40                  45              


Leu Asp Ala Ser Leu Ser Pro Val Ile Leu Gly Val Gln Gly Gly Ser 
    50                  55                  60                  


Gln Cys Leu Ser Cys Gly Val Gly Gln Glu Pro Thr Leu Thr Leu Glu 
65                  70                  75                  80  


Pro Val Asn Ile Met Glu Leu Tyr Leu Gly Ala Lys Glu Ser Lys Ser 
                85                  90                  95      


Phe Thr Phe Tyr Arg Arg Asp Met Gly Leu Thr Ser Ser Phe Glu Ser 
            100                 105                 110         


Ala Ala Tyr Pro Gly Trp Phe Leu Cys Thr Val Pro Glu Ala Asp Gln 
        115                 120                 125             


Pro Val Arg Leu Thr Gln Leu Pro Glu Asn Gly Gly Trp Asn Ala Pro 
    130                 135                 140                 


Ile Thr Asp Phe Tyr Phe Gln Gln Cys Asp 
145                 150                 


<210> 35
<211> 154
<212> PRT
<213> Mus sp.

<400> 35
Val Leu Ser Gly Ala Leu Cys Phe Arg Met Lys Asp Ser Ala Leu Lys 
1               5                   10                  15      


Val Leu Tyr Leu His Asn Asn Gln Leu Leu Ala Gly Gly Leu His Ala 
            20                  25                  30          


Glu Lys Val Ile Lys Gly Glu Glu Ile Ser Val Val Pro Asn Arg Ala 
        35                  40                  45              


Leu Asp Ala Ser Leu Ser Pro Val Ile Leu Gly Val Gln Gly Gly Ser 
    50                  55                  60                  


Gln Cys Leu Ser Cys Gly Thr Glu Lys Gly Pro Ile Leu Lys Leu Glu 
65                  70                  75                  80  


Pro Val Asn Ile Met Glu Leu Tyr Leu Gly Ala Lys Glu Ser Lys Ser 
                85                  90                  95      


Phe Thr Phe Tyr Arg Arg Asp Met Gly Leu Thr Ser Ser Phe Glu Ser 
            100                 105                 110         


Ala Ala Tyr Pro Gly Trp Phe Leu Cys Thr Ser Pro Glu Ala Asp Gln 
        115                 120                 125             


Pro Val Arg Leu Thr Gln Ile Pro Glu Asp Pro Ala Trp Asp Ala Pro 
    130                 135                 140                 


Ile Thr Asp Phe Tyr Phe Gln Gln Cys Asp 
145                 150                 


<210> 36
<211> 173
<212> PRT
<213> Homo sapiens

<400> 36
Val His Thr Ser Pro Lys Val Lys Asn Leu Asn Pro Lys Lys Phe Ser 
1               5                   10                  15      


Ile His Asp Gln Asp His Lys Val Leu Val Leu Asp Ser Gly Asn Leu 
            20                  25                  30          


Ile Ala Val Pro Asp Lys Asn Tyr Ile Arg Pro Glu Ile Phe Phe Ala 
        35                  40                  45              


Leu Ala Ser Ser Leu Ser Ser Ala Ser Ala Glu Lys Gly Ser Pro Ile 
    50                  55                  60                  


Leu Leu Gly Val Ser Lys Gly Glu Phe Cys Leu Tyr Cys Asp Lys Asp 
65                  70                  75                  80  


Lys Gly Gln Ser His Pro Ser Leu Gln Leu Lys Lys Glu Lys Leu Met 
                85                  90                  95      


Lys Leu Ala Ala Gln Lys Glu Ser Ala Arg Arg Pro Phe Ile Phe Tyr 
            100                 105                 110         


Arg Ala Gln Val Gly Ser Trp Asn Met Leu Glu Ser Ala Ala His Pro 
        115                 120                 125             


Gly Trp Phe Ile Cys Thr Ser Cys Asn Cys Asn Glu Pro Val Gly Val 
    130                 135                 140                 


Thr Asp Lys Phe Glu Asn Arg Lys His Ile Glu Phe Ser Phe Gln Pro 
145                 150                 155                 160 


Val Cys Lys Ala Glu Met Ser Pro Ser Glu Val Ser Asp 
                165                 170             


<210> 37
<211> 171
<212> PRT
<213> Mus sp.

<400> 37
Val Pro Ser Ser Ala Lys Val Asn Ala Arg Ala Pro Glu Lys Phe Ser 
1               5                   10                  15      


Ile Arg Asp Gln Asp Gln Lys Val Leu Val Leu Ser Asp Glu Thr Leu 
            20                  25                  30          


Ile Ala Val Pro Asn Lys Pro Tyr Thr Val Pro Glu Thr Phe Phe Val 
        35                  40                  45              


Leu Ala Ser His Thr Ser Ser Ser His Glu Gly Ser Pro Ile Leu Leu 
    50                  55                  60                  


Ala Val Ser Lys Gly Glu Leu Cys Leu Cys Cys Asp Lys Asp Glu Glu 
65                  70                  75                  80  


Gln Ser Lys Pro Ser Leu Gln Leu Lys Lys Asn Glu Leu Met Lys Leu 
                85                  90                  95      


Ala Thr Gln Lys Glu Lys Val Arg Leu Pro Phe Val Phe Tyr Arg Ala 
            100                 105                 110         


Gln Val Gly Ser Cys Cys Thr Leu Glu Ser Ala Ala His Pro Gly Trp 
        115                 120                 125             


Phe Val Cys Thr Ser Arg Asn Ser Gly Ala Pro Val Glu Val Thr Asp 
    130                 135                 140                 


Thr Ser Gly Glu Gly Lys Leu Met Glu Phe Ser Phe Gln Gln Val Ser 
145                 150                 155                 160 


Glu Thr Glu Met Ser Pro Ser Glu Val Ser Ile 
                165                 170     


<210> 38
<211> 165
<212> PRT
<213> Homo sapiens

<400> 38
Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn Phe Gln Cys 
1               5                   10                  15      


Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr Cys Leu Lys 
            20                  25                  30          


Asp Arg Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu Gln Gln 
        35                  40                  45              


Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met Leu Gln Asn 
    50                  55                  60                  


Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn Glu 
65                  70                  75                  80  


Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn His 
                85                  90                  95      


Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr Arg 
            100                 105                 110         


Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg Ile 
        115                 120                 125             


Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala Trp Thr Ile 
    130                 135                 140                 


Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu Thr 
145                 150                 155                 160 


Gly Tyr Leu Arg Asn 
                165 


<210> 39
<211> 161
<212> PRT
<213> Mus sp.

<400> 39
Ile Asn Tyr Lys Gln Leu Gln Leu Gln Glu Arg Thr Asn Ile Arg Lys 
1               5                   10                  15      


Cys Gln Glu Leu Leu Glu Gln Leu Asn Gly Lys Ile Asn Leu Thr Tyr 
            20                  25                  30          


Arg Ala Asp Phe Lys Ile Pro Met Glu Met Thr Glu Lys Met Gln Lys 
        35                  40                  45              


Ser Tyr Thr Ala Phe Ala Ile Gln Glu Met Leu Gln Asn Val Phe Leu 
    50                  55                  60                  


Val Phe Arg Asn Asn Phe Ser Ser Thr Gly Trp Asn Glu Thr Ile Val 
65                  70                  75                  80  


Val Arg Leu Leu Asp Glu Leu His Gln Gln Thr Val Phe Leu Lys Thr 
                85                  90                  95      


Val Leu Glu Glu Lys Gln Glu Glu Arg Leu Thr Trp Glu Met Ser Ser 
            100                 105                 110         


Thr Ala Leu His Leu Lys Ser Tyr Tyr Trp Arg Val Gln Arg Tyr Leu 
        115                 120                 125             


Lys Leu Met Lys Tyr Asn Ser Tyr Ala Trp Met Val Val Arg Ala Glu 
    130                 135                 140                 


Ile Phe Arg Asn Phe Leu Ile Ile Arg Arg Leu Thr Arg Asn Phe Gln 
145                 150                 155                 160 


Asn 
    


<210> 40
<211> 112
<212> PRT
<213> Homo sapiens

<400> 40
Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210> 41
<211> 112
<212> PRT
<213> Mus sp.

<400> 41
Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210> 42
<211> 161
<212> PRT
<213> Homo sapiens

<400> 42
Asp Ser Val Cys Pro Gln Gly Lys Tyr Ile His Pro Gln Asn Asn Ser 
1               5                   10                  15      


Ile Cys Cys Thr Lys Cys His Lys Gly Thr Tyr Leu Tyr Asn Asp Cys 
            20                  25                  30          


Pro Gly Pro Gly Gln Asp Thr Asp Cys Arg Glu Cys Glu Ser Gly Ser 
        35                  40                  45              


Phe Thr Ala Ser Glu Asn His Leu Arg His Cys Leu Ser Cys Ser Lys 
    50                  55                  60                  


Cys Arg Lys Glu Met Gly Gln Val Glu Ile Ser Ser Cys Thr Val Asp 
65                  70                  75                  80  


Arg Asp Thr Val Cys Gly Cys Arg Lys Asn Gln Tyr Arg His Tyr Trp 
                85                  90                  95      


Ser Glu Asn Leu Phe Gln Cys Phe Asn Cys Ser Leu Cys Leu Asn Gly 
            100                 105                 110         


Thr Val His Leu Ser Cys Gln Glu Lys Gln Asn Thr Val Cys Thr Cys 
        115                 120                 125             


His Ala Gly Phe Phe Leu Arg Glu Asn Glu Cys Val Ser Cys Ser Asn 
    130                 135                 140                 


Cys Lys Lys Ser Leu Glu Cys Thr Lys Leu Cys Leu Pro Gln Ile Glu 
145                 150                 155                 160 


Asn 
    


<210> 43
<211> 439
<212> PRT
<213> Homo sapiens

<400> 43
Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Phe Ala Leu Pro Val 
225                 230                 235                 240 


Gly Leu Ile Val Gly Val Thr Ala Leu Gly Leu Leu Ile Ile Gly Val 
                245                 250                 255     


Val Asn Cys Val Ile Met Thr Gln Val Lys Lys Lys Pro Leu Cys Leu 
            260                 265                 270         


Gln Arg Glu Ala Lys Val Pro His Leu Pro Ala Asp Lys Ala Arg Gly 
        275                 280                 285             


Thr Gln Gly Pro Glu Gln Gln His Leu Leu Ile Thr Ala Pro Ser Ser 
    290                 295                 300                 


Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser Ala Leu Asp Arg Arg Ala 
305                 310                 315                 320 


Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly Val Glu Ala Ser Gly Ala 
                325                 330                 335     


Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser Asp Ser Ser Pro Gly Gly 
            340                 345                 350         


His Gly Thr Gln Val Asn Val Thr Cys Ile Val Asn Val Cys Ser Ser 
        355                 360                 365             


Ser Asp His Ser Ser Gln Cys Ser Ser Gln Ala Ser Ser Thr Met Gly 
    370                 375                 380                 


Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro Lys Asp Glu Gln Val Pro 
385                 390                 395                 400 


Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser Gln Leu Glu Thr Pro Glu 
                405                 410                 415     


Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro Leu Pro Leu Gly Val Pro 
            420                 425                 430         


Asp Ala Gly Met Lys Pro Ser 
        435                 


<210> 44
<211> 236
<212> PRT
<213> Mus sp.

<400> 44
Val Pro Ala Gln Val Val Leu Thr Pro Tyr Lys Pro Glu Pro Gly Tyr 
1               5                   10                  15      


Glu Cys Gln Ile Ser Gln Glu Tyr Tyr Asp Arg Lys Ala Gln Met Cys 
            20                  25                  30          


Cys Ala Lys Cys Pro Pro Gly Gln Tyr Val Lys His Phe Cys Asn Lys 
        35                  40                  45              


Thr Ser Asp Thr Val Cys Ala Asp Cys Glu Ala Ser Met Tyr Thr Gln 
    50                  55                  60                  


Val Trp Asn Gln Phe Arg Thr Cys Leu Ser Cys Ser Ser Ser Cys Thr 
65                  70                  75                  80  


Thr Asp Gln Val Glu Ile Arg Ala Cys Thr Lys Gln Gln Asn Arg Val 
                85                  90                  95      


Cys Ala Cys Glu Ala Gly Arg Tyr Cys Ala Leu Lys Thr His Ser Gly 
            100                 105                 110         


Ser Cys Arg Gln Cys Met Arg Leu Ser Lys Cys Gly Pro Gly Phe Gly 
        115                 120                 125             


Val Ala Ser Ser Arg Ala Pro Asn Gly Asn Val Leu Cys Lys Ala Cys 
    130                 135                 140                 


Ala Pro Gly Thr Phe Ser Asp Thr Thr Ser Ser Thr Asp Val Cys Arg 
145                 150                 155                 160 


Pro His Arg Ile Cys Ser Ile Leu Ala Ile Pro Gly Asn Ala Ser Thr 
                165                 170                 175     


Asp Ala Val Cys Ala Pro Glu Ser Pro Thr Leu Ser Ala Ile Pro Arg 
            180                 185                 190         


Thr Leu Tyr Val Ser Gln Pro Glu Pro Thr Arg Ser Gln Pro Leu Asp 
        195                 200                 205             


Gln Glu Pro Gly Pro Ser Gln Thr Pro Ser Ile Leu Thr Ser Leu Gly 
    210                 215                 220                 


Ser Thr Pro Ile Ile Glu Gln Ser Thr Lys Gly Gly 
225                 230                 235     


<210> 45
<211> 608
<212> PRT
<213> Homo sapiens

<400> 45
Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala Tyr 
1               5                   10                  15      


Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala His 
            20                  25                  30          


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
        35                  40                  45              


Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys 
    50                  55                  60                  


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
65                  70                  75                  80  


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
                85                  90                  95      


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
            100                 105                 110         


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
        115                 120                 125             


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
    130                 135                 140                 


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
145                 150                 155                 160 


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
                165                 170                 175     


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
            180                 185                 190         


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
        195                 200                 205             


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
    210                 215                 220                 


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
225                 230                 235                 240 


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
                245                 250                 255     


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
            260                 265                 270         


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
        275                 280                 285             


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
    290                 295                 300                 


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
305                 310                 315                 320 


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
                325                 330                 335     


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
            340                 345                 350         


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
        355                 360                 365             


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
    370                 375                 380                 


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
385                 390                 395                 400 


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
                405                 410                 415     


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
            420                 425                 430         


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
        435                 440                 445             


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
    450                 455                 460                 


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
465                 470                 475                 480 


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
                485                 490                 495     


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
            500                 505                 510         


Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu 
        515                 520                 525             


Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 
    530                 535                 540                 


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 
545                 550                 555                 560 


Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 
                565                 570                 575     


Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 
            580                 585                 590         


Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
        595                 600                 605             


<210> 46
<211> 584
<212> PRT
<213> Mus sp.

<400> 46
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Cys Lys Asp Ala Leu Ala 
            580                 


<210> 47
<211> 193
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      vWF A3 sequence

<400> 47
Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
        35                  40                  45              


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
    50                  55                  60                  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
                85                  90                  95      


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe Val Arg 
            180                 185                 190         


Ile 
    


<210> 48
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210> 49
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(40)
<223> This sequence may encompass 1-10 "Gly Gly Gly Ser"
      repeating units

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 49
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40  


<210> 50
<211> 785
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
        35                  40                  45              


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
    50                  55                  60                  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
                85                  90                  95      


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe Val Arg 
            180                 185                 190         


Ile Gly Gly Gly Ser Gly Gly Gly Ser Glu Ala His Lys Ser Glu Ile 
        195                 200                 205             


Ala His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val 
    210                 215                 220                 


Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His 
225                 230                 235                 240 


Ala Lys Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala 
                245                 250                 255     


Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
            260                 265                 270         


Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu 
        275                 280                 285             


Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
    290                 295                 300                 


Gln His Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu 
305                 310                 315                 320 


Ala Glu Ala Met Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met 
                325                 330                 335     


Gly His Tyr Leu His Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala 
            340                 345                 350         


Pro Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln 
        355                 360                 365             


Cys Cys Ala Glu Ala Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp 
    370                 375                 380                 


Gly Val Lys Glu Lys Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys 
385                 390                 395                 400 


Cys Ser Ser Met Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
                405                 410                 415     


Val Ala Arg Leu Ser Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile 
            420                 425                 430         


Thr Lys Leu Ala Thr Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His 
        435                 440                 445             


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr 
    450                 455                 460                 


Met Cys Glu Asn Gln Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys 
465                 470                 475                 480 


Asp Lys Pro Leu Leu Lys Lys Ala His Cys Leu Ser Glu Val Glu His 
                485                 490                 495     


Asp Thr Met Pro Ala Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu 
            500                 505                 510         


Asp Gln Glu Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
        515                 520                 525             


Gly Thr Phe Leu Tyr Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val 
    530                 535                 540                 


Ser Leu Leu Leu Arg Leu Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys 
545                 550                 555                 560 


Cys Cys Ala Glu Ala Asn Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala 
                565                 570                 575     


Glu Phe Gln Pro Leu Val Glu Glu Pro Lys Asn Leu Val Lys Thr Asn 
            580                 585                 590         


Cys Asp Leu Tyr Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile 
        595                 600                 605             


Leu Val Arg Tyr Thr Gln Lys Ala Pro Gln Val Ser Thr Pro Thr Leu 
    610                 615                 620                 


Val Glu Ala Ala Arg Asn Leu Gly Arg Val Gly Thr Lys Cys Cys Thr 
625                 630                 635                 640 


Leu Pro Glu Asp Gln Arg Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala 
                645                 650                 655     


Ile Leu Asn Arg Val Cys Leu Leu His Glu Lys Thr Pro Val Ser Glu 
            660                 665                 670         


His Val Thr Lys Cys Cys Ser Gly Ser Leu Val Glu Arg Arg Pro Cys 
        675                 680                 685             


Phe Ser Ala Leu Thr Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys 
    690                 695                 700                 


Ala Glu Thr Phe Thr Phe His Ser Asp Ile Cys Thr Leu Pro Glu Lys 
705                 710                 715                 720 


Glu Lys Gln Ile Lys Lys Gln Thr Ala Leu Ala Glu Leu Val Lys His 
                725                 730                 735     


Lys Pro Lys Ala Thr Ala Glu Gln Leu Lys Thr Val Met Asp Asp Phe 
            740                 745                 750         


Ala Gln Phe Leu Asp Thr Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys 
        755                 760                 765             


Phe Ser Thr Glu Gly Pro Asn Leu Val Thr Arg Cys Lys Asp Ala Leu 
    770                 775                 780                 


Ala 
785 


<210> 51
<211> 809
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
        35                  40                  45              


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
    50                  55                  60                  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
                85                  90                  95      


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe Val Arg 
            180                 185                 190         


Ile Gly Gly Gly Ser Gly Gly Gly Ser Lys Trp Val Thr Phe Ile Ser 
        195                 200                 205             


Leu Leu Phe Leu Phe Ser Ser Ala Tyr Ser Arg Gly Val Phe Arg Arg 
    210                 215                 220                 


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
225                 230                 235                 240 


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
                245                 250                 255     


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
            260                 265                 270         


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
        275                 280                 285             


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
    290                 295                 300                 


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
305                 310                 315                 320 


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
                325                 330                 335     


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
            340                 345                 350         


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
        355                 360                 365             


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
    370                 375                 380                 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
385                 390                 395                 400 


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
                405                 410                 415     


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
            420                 425                 430         


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
        435                 440                 445             


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
    450                 455                 460                 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
465                 470                 475                 480 


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
                485                 490                 495     


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
            500                 505                 510         


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
        515                 520                 525             


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
    530                 535                 540                 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
545                 550                 555                 560 


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
                565                 570                 575     


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
            580                 585                 590         


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
        595                 600                 605             


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
    610                 615                 620                 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
625                 630                 635                 640 


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
                645                 650                 655     


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
            660                 665                 670         


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
        675                 680                 685             


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
    690                 695                 700                 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
705                 710                 715                 720 


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
                725                 730                 735     


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
            740                 745                 750         


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
        755                 760                 765             


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
    770                 775                 780                 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
785                 790                 795                 800 


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
                805                 


<210> 52
<211> 193
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      vWF A3 sequence

<400> 52
Cys Ser Gln Pro Leu Asp Val Val Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Leu Pro Glu Ser Ser Phe Asp Lys Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro His Leu Thr Gln Val Ser Val Ile 
        35                  40                  45              


Gln Tyr Gly Ser Ile Asn Thr Ile Asp Val Pro Trp Asn Val Val Gln 
    50                  55                  60                  


Glu Lys Ala His Leu Gln Ser Leu Val Asp Leu Met Gln Gln Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Ala Phe Ala Val Arg Tyr Val 
                85                  90                  95      


Thr Ser Gln Ile His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Ile Ile Met Asp Thr Ser Leu Asp Pro Val Asp Thr Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Ala Val Phe Pro Val Gly Val Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Glu Ala Gln Leu Arg Ile Leu Ala Gly Pro Gly Ala Ser 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Gln Val Glu Asp Leu Ser Thr Met Ala 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Phe His Lys Leu Cys Ser Gly Phe Ser Gly 
            180                 185                 190         


Val 
    


<210> 53
<211> 165
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His Phe Pro Val 
1               5                   10                  15      


Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe Ser Gln Val 
            20                  25                  30          


Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile Leu Leu Thr 
        35                  40                  45              


Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu 
    50                  55                  60                  


Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro Gln Ala Glu 
65                  70                  75                  80  


Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu Gly Glu Lys 
                85                  90                  95      


Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg Phe Leu Pro 
            100                 105                 110         


Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser Asp Phe Asn 
        115                 120                 125             


Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu Phe Asp Ile 
    130                 135                 140                 


Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met Lys Ser His 
145                 150                 155                 160 


His His His His His 
                165 


<210> 54
<211> 758
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Cys Lys Asp Ala Leu Ala Gly Gly Gly Ser Gly Gly Gly Ser 
            580                 585                 590         


Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His Phe Pro 
        595                 600                 605             


Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe Ser Gln 
    610                 615                 620                 


Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile Leu Leu 
625                 630                 635                 640 


Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
                645                 650                 655     


Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro Gln Ala 
            660                 665                 670         


Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu Gly Glu 
        675                 680                 685             


Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg Phe Leu 
    690                 695                 700                 


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser Asp Phe 
705                 710                 715                 720 


Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu Phe Asp 
                725                 730                 735     


Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met Lys Ser 
            740                 745                 750         


His His His His His His 
        755             


<210> 55
<211> 959
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Cys Ser Gln Pro Leu Asp Val Val Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Leu Pro Glu Ser Ser Phe Asp Lys Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro His Leu Thr Gln Val Ser Val Ile 
        35                  40                  45              


Gln Tyr Gly Ser Ile Asn Thr Ile Asp Val Pro Trp Asn Val Val Gln 
    50                  55                  60                  


Glu Lys Ala His Leu Gln Ser Leu Val Asp Leu Met Gln Gln Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Ala Phe Ala Val Arg Tyr Val 
                85                  90                  95      


Thr Ser Gln Ile His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Ile Ile Met Asp Thr Ser Leu Asp Pro Val Asp Thr Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Ala Val Phe Pro Val Gly Val Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Glu Ala Gln Leu Arg Ile Leu Ala Gly Pro Gly Ala Ser 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Gln Val Glu Asp Leu Ser Thr Met Ala 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Phe His Lys Leu Cys Ser Gly Phe Ser Gly 
            180                 185                 190         


Val Gly Gly Gly Ser Gly Gly Gly Ser Glu Ala His Lys Ser Glu Ile 
        195                 200                 205             


Ala His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val 
    210                 215                 220                 


Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His 
225                 230                 235                 240 


Ala Lys Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala 
                245                 250                 255     


Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
            260                 265                 270         


Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu 
        275                 280                 285             


Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
    290                 295                 300                 


Gln His Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu 
305                 310                 315                 320 


Ala Glu Ala Met Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met 
                325                 330                 335     


Gly His Tyr Leu His Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala 
            340                 345                 350         


Pro Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln 
        355                 360                 365             


Cys Cys Ala Glu Ala Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp 
    370                 375                 380                 


Gly Val Lys Glu Lys Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys 
385                 390                 395                 400 


Cys Ser Ser Met Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
                405                 410                 415     


Val Ala Arg Leu Ser Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile 
            420                 425                 430         


Thr Lys Leu Ala Thr Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His 
        435                 440                 445             


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr 
    450                 455                 460                 


Met Cys Glu Asn Gln Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys 
465                 470                 475                 480 


Asp Lys Pro Leu Leu Lys Lys Ala His Cys Leu Ser Glu Val Glu His 
                485                 490                 495     


Asp Thr Met Pro Ala Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu 
            500                 505                 510         


Asp Gln Glu Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
        515                 520                 525             


Gly Thr Phe Leu Tyr Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val 
    530                 535                 540                 


Ser Leu Leu Leu Arg Leu Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys 
545                 550                 555                 560 


Cys Cys Ala Glu Ala Asn Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala 
                565                 570                 575     


Glu Phe Gln Pro Leu Val Glu Glu Pro Lys Asn Leu Val Lys Thr Asn 
            580                 585                 590         


Cys Asp Leu Tyr Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile 
        595                 600                 605             


Leu Val Arg Tyr Thr Gln Lys Ala Pro Gln Val Ser Thr Pro Thr Leu 
    610                 615                 620                 


Val Glu Ala Ala Arg Asn Leu Gly Arg Val Gly Thr Lys Cys Cys Thr 
625                 630                 635                 640 


Leu Pro Glu Asp Gln Arg Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala 
                645                 650                 655     


Ile Leu Asn Arg Val Cys Leu Leu His Glu Lys Thr Pro Val Ser Glu 
            660                 665                 670         


His Val Thr Lys Cys Cys Ser Gly Ser Leu Val Glu Arg Arg Pro Cys 
        675                 680                 685             


Phe Ser Ala Leu Thr Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys 
    690                 695                 700                 


Ala Glu Thr Phe Thr Phe His Ser Asp Ile Cys Thr Leu Pro Glu Lys 
705                 710                 715                 720 


Glu Lys Gln Ile Lys Lys Gln Thr Ala Leu Ala Glu Leu Val Lys His 
                725                 730                 735     


Lys Pro Lys Ala Thr Ala Glu Gln Leu Lys Thr Val Met Asp Asp Phe 
            740                 745                 750         


Ala Gln Phe Leu Asp Thr Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys 
        755                 760                 765             


Phe Ser Thr Glu Gly Pro Asn Leu Val Thr Arg Cys Lys Asp Ala Leu 
    770                 775                 780                 


Ala Gly Gly Gly Ser Gly Gly Gly Ser Ser Arg Gly Gln Tyr Ser Arg 
785                 790                 795                 800 


Glu Asp Asn Asn Cys Thr His Phe Pro Val Gly Gln Ser His Met Leu 
                805                 810                 815     


Leu Glu Leu Arg Thr Ala Phe Ser Gln Val Lys Thr Phe Phe Gln Thr 
            820                 825                 830         


Lys Asp Gln Leu Asp Asn Ile Leu Leu Thr Asp Ser Leu Met Gln Asp 
        835                 840                 845             


Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe 
    850                 855                 860                 


Tyr Leu Val Glu Val Met Pro Gln Ala Glu Lys His Gly Pro Glu Ile 
865                 870                 875                 880 


Lys Glu His Leu Asn Ser Leu Gly Glu Lys Leu Lys Thr Leu Arg Met 
                885                 890                 895     


Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys 
            900                 905                 910         


Ala Val Glu Gln Val Lys Ser Asp Phe Asn Lys Leu Gln Asp Gln Gly 
        915                 920                 925             


Val Tyr Lys Ala Met Asn Glu Phe Asp Ile Phe Ile Asn Cys Ile Glu 
    930                 935                 940                 


Ala Tyr Met Met Ile Lys Met Lys Ser His His His His His His 
945                 950                 955                 


<210> 56
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met His Ile His Gly Cys Asp Lys Asn His Leu Arg Glu Ile Ile Gly 
1               5                   10                  15      


Ile Leu Asn Glu Val Thr Gly Glu Gly Thr Pro Cys Thr Glu Met Asp 
            20                  25                  30          


Val Pro Asn Val Leu Thr Ala Thr Lys Asn Thr Thr Glu Ser Glu Leu 
        35                  40                  45              


Val Cys Arg Ala Ser Lys Val Leu Arg Ile Phe Tyr Leu Lys His Gly 
    50                  55                  60                  


Lys Thr Pro Cys Leu Lys Lys Asn Ser Ser Val Leu Met Glu Leu Gln 
65                  70                  75                  80  


Arg Leu Phe Arg Ala Phe Arg Cys Leu Asp Ser Ser Ile Ser Cys Thr 
                85                  90                  95      


Met Asn Glu Ser Lys Ser Thr Ser Leu Lys Asp Phe Leu Glu Ser Leu 
            100                 105                 110         


Lys Ser Ile Met Gln Met Asp Tyr Ser His His His His His His 
        115                 120                 125         


<210> 57
<211> 720
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Cys Lys Asp Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Ser Met His Ile His Gly Cys Asp Lys Asn His Leu Arg Glu Ile Ile 
        595                 600                 605             


Gly Ile Leu Asn Glu Val Thr Gly Glu Gly Thr Pro Cys Thr Glu Met 
    610                 615                 620                 


Asp Val Pro Asn Val Leu Thr Ala Thr Lys Asn Thr Thr Glu Ser Glu 
625                 630                 635                 640 


Leu Val Cys Arg Ala Ser Lys Val Leu Arg Ile Phe Tyr Leu Lys His 
                645                 650                 655     


Gly Lys Thr Pro Cys Leu Lys Lys Asn Ser Ser Val Leu Met Glu Leu 
            660                 665                 670         


Gln Arg Leu Phe Arg Ala Phe Arg Cys Leu Asp Ser Ser Ile Ser Cys 
        675                 680                 685             


Thr Met Asn Glu Ser Lys Ser Thr Ser Leu Lys Asp Phe Leu Glu Ser 
    690                 695                 700                 


Leu Lys Ser Ile Met Gln Met Asp Tyr Ser His His His His His His 
705                 710                 715                 720 


<210> 58
<211> 202
<212> PRT
<213> Mus sp.

<400> 58
Gln Val Glu Val Val Thr Gln Asp Glu Arg Lys Ala Leu His Thr Thr 
1               5                   10                  15      


Ala Ser Leu Arg Cys Ser Leu Lys Thr Ser Gln Glu Pro Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Tyr 
        35                  40                  45              


Ser Lys Thr His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Arg Ile 
    50                  55                  60                  


Asn Val Thr Glu Leu Gly Leu Trp Asn Ser Ser Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Thr Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Ser Gln Lys Val Ser Gly Thr Ala Cys Leu Thr Leu Tyr Val Gln 
            100                 105                 110         


Pro Ile Val His Leu His Tyr Asn Tyr Phe Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Ala Ile Ser Trp Lys Gly 
    130                 135                 140                 


Thr Gly Thr Gly Ile Glu Asn Ser Thr Glu Ser His Phe His Ser Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu Arg Val Lys Asp Pro Lys Thr 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu Tyr Leu Gly Asn Val 
            180                 185                 190         


Ile Asp Tyr Lys Gln Ser Leu Asp Lys Gly 
        195                 200         


<210> 59
<211> 202
<212> PRT
<213> Homo sapiens

<400> 59
Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro 
1               5                   10                  15      


Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe 
        35                  40                  45              


Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile 
    50                  55                  60                  


Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln 
            100                 105                 110         


Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val 
    130                 135                 140                 


Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val 
            180                 185                 190         


Thr Asp Phe Lys Gln Thr Val Asn Lys Gly 
        195                 200         


<210> 60
<211> 585
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      serum albumin sequence

<400> 60
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210> 61
<211> 795
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro 
1               5                   10                  15      


Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe 
        35                  40                  45              


Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile 
    50                  55                  60                  


Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln 
            100                 105                 110         


Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val 
    130                 135                 140                 


Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val 
            180                 185                 190         


Thr Asp Phe Lys Gln Thr Val Asn Lys Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu 
    210                 215                 220                 


Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr 
225                 230                 235                 240 


Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val 
                245                 250                 255     


Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys 
            260                 265                 270         


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala 
        275                 280                 285             


Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln 
    290                 295                 300                 


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
305                 310                 315                 320 


Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala 
                325                 330                 335     


Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile 
            340                 345                 350         


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 
        355                 360                 365             


Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 
    370                 375                 380                 


Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 
385                 390                 395                 400 


Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 
                405                 410                 415     


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 
            420                 425                 430         


Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 
        435                 440                 445             


Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
    450                 455                 460                 


Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 
465                 470                 475                 480 


Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 
                485                 490                 495     


Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 
            500                 505                 510         


Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 
        515                 520                 525             


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 
    530                 535                 540                 


Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala 
545                 550                 555                 560 


Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro 
                565                 570                 575     


His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu 
            580                 585                 590         


Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu 
        595                 600                 605             


Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys 
    610                 615                 620                 


Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu 
625                 630                 635                 640 


Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met 
                645                 650                 655     


Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val 
            660                 665                 670         


Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr 
        675                 680                 685             


Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp 
    690                 695                 700                 


Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His 
705                 710                 715                 720 


Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln 
                725                 730                 735     


Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu 
            740                 745                 750         


Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys 
        755                 760                 765             


Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys 
    770                 775                 780                 


Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
785                 790                 795 


<210> 62
<211> 403
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Gln Val Glu Val Val Thr Gln Asp Glu Arg Lys Ala Leu His Thr Thr 
1               5                   10                  15      


Ala Ser Leu Arg Cys Ser Leu Lys Thr Ser Gln Glu Pro Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Tyr 
        35                  40                  45              


Ser Lys Thr His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Arg Ile 
    50                  55                  60                  


Asn Val Thr Glu Leu Gly Leu Trp Asn Ser Ser Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Thr Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Ser Gln Lys Val Ser Gly Thr Ala Cys Leu Thr Leu Tyr Val Gln 
            100                 105                 110         


Pro Ile Val His Leu His Tyr Asn Tyr Phe Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Ala Ile Ser Trp Lys Gly 
    130                 135                 140                 


Thr Gly Thr Gly Ile Glu Asn Ser Thr Glu Ser His Phe His Ser Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu Arg Val Lys Asp Pro Lys Thr 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu Tyr Leu Gly Asn Val 
            180                 185                 190         


Ile Asp Tyr Lys Gln Ser Leu Asp Lys Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser 
    210                 215                 220                 


Ser Ser Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys 
225                 230                 235                 240 


Ala Phe Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser 
                245                 250                 255     


Val Leu Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val 
            260                 265                 270         


Val Pro Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg 
        275                 280                 285             


Glu Gly Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg 
    290                 295                 300                 


Tyr Leu Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala 
305                 310                 315                 320 


Val Val Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala 
                325                 330                 335     


Ala Asp Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile 
            340                 345                 350         


Gly Asp Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala 
        355                 360                 365             


Gly Asp Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr 
    370                 375                 380                 


Met Val Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe 
385                 390                 395                 400 


Val Arg Ile 
            


<210> 63
<211> 403
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro 
1               5                   10                  15      


Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe 
        35                  40                  45              


Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile 
    50                  55                  60                  


Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln 
            100                 105                 110         


Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val 
    130                 135                 140                 


Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val 
            180                 185                 190         


Thr Asp Phe Lys Gln Thr Val Asn Lys Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser 
    210                 215                 220                 


Ser Ser Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys 
225                 230                 235                 240 


Ala Phe Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser 
                245                 250                 255     


Val Leu Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val 
            260                 265                 270         


Val Pro Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg 
        275                 280                 285             


Glu Gly Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg 
    290                 295                 300                 


Tyr Leu Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala 
305                 310                 315                 320 


Val Val Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala 
                325                 330                 335     


Ala Asp Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile 
            340                 345                 350         


Gly Asp Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala 
        355                 360                 365             


Gly Asp Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr 
    370                 375                 380                 


Met Val Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe 
385                 390                 395                 400 


Val Arg Ile 
            


<210> 64
<211> 995
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Gln Val Glu Val Val Thr Gln Asp Glu Arg Lys Ala Leu His Thr Thr 
1               5                   10                  15      


Ala Ser Leu Arg Cys Ser Leu Lys Thr Ser Gln Glu Pro Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Tyr 
        35                  40                  45              


Ser Lys Thr His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Arg Ile 
    50                  55                  60                  


Asn Val Thr Glu Leu Gly Leu Trp Asn Ser Ser Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Thr Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Ser Gln Lys Val Ser Gly Thr Ala Cys Leu Thr Leu Tyr Val Gln 
            100                 105                 110         


Pro Ile Val His Leu His Tyr Asn Tyr Phe Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Ala Ile Ser Trp Lys Gly 
    130                 135                 140                 


Thr Gly Thr Gly Ile Glu Asn Ser Thr Glu Ser His Phe His Ser Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu Arg Val Lys Asp Pro Lys Thr 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu Tyr Leu Gly Asn Val 
            180                 185                 190         


Ile Asp Tyr Lys Gln Ser Leu Asp Lys Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu 
    210                 215                 220                 


Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr 
225                 230                 235                 240 


Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val 
                245                 250                 255     


Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys 
            260                 265                 270         


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro 
        275                 280                 285             


Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln 
    290                 295                 300                 


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
305                 310                 315                 320 


Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser 
                325                 330                 335     


Phe Lys Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val 
            340                 345                 350         


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala 
        355                 360                 365             


Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys 
    370                 375                 380                 


Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu 
385                 390                 395                 400 


Val Ser Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe 
                405                 410                 415     


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr 
            420                 425                 430         


Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu 
        435                 440                 445             


Thr Lys Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
    450                 455                 460                 


Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr 
465                 470                 475                 480 


Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys 
                485                 490                 495     


Ala His Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu 
            500                 505                 510         


Pro Ala Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn 
        515                 520                 525             


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr 
    530                 535                 540                 


Ser Arg Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala 
545                 550                 555                 560 


Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro 
                565                 570                 575     


Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu 
            580                 585                 590         


Glu Pro Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu 
        595                 600                 605             


Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys 
    610                 615                 620                 


Ala Pro Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu 
625                 630                 635                 640 


Gly Arg Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu 
                645                 650                 655     


Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu 
            660                 665                 670         


Leu His Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser 
        675                 680                 685             


Gly Ser Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp 
    690                 695                 700                 


Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His 
705                 710                 715                 720 


Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln 
                725                 730                 735     


Thr Ala Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu 
            740                 745                 750         


Gln Leu Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys 
        755                 760                 765             


Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn 
    770                 775                 780                 


Leu Val Thr Arg Cys Lys Asp Ala Leu Ala Gly Gly Gly Ser Gly Gly 
785                 790                 795                 800 


Gly Ser Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser 
                805                 810                 815     


Ser Ser Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys 
            820                 825                 830         


Ala Phe Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser 
        835                 840                 845             


Val Leu Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val 
    850                 855                 860                 


Val Pro Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg 
865                 870                 875                 880 


Glu Gly Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg 
                885                 890                 895     


Tyr Leu Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala 
            900                 905                 910         


Val Val Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala 
        915                 920                 925             


Ala Asp Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile 
    930                 935                 940                 


Gly Asp Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala 
945                 950                 955                 960 


Gly Asp Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr 
                965                 970                 975     


Met Val Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe 
            980                 985                 990         


Val Arg Ile 
        995 


<210> 65
<211> 996
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro 
1               5                   10                  15      


Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe 
        35                  40                  45              


Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile 
    50                  55                  60                  


Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln 
            100                 105                 110         


Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val 
    130                 135                 140                 


Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val 
            180                 185                 190         


Thr Asp Phe Lys Gln Thr Val Asn Lys Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu 
    210                 215                 220                 


Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr 
225                 230                 235                 240 


Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val 
                245                 250                 255     


Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys 
            260                 265                 270         


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala 
        275                 280                 285             


Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln 
    290                 295                 300                 


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
305                 310                 315                 320 


Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala 
                325                 330                 335     


Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile 
            340                 345                 350         


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 
        355                 360                 365             


Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 
    370                 375                 380                 


Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 
385                 390                 395                 400 


Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 
                405                 410                 415     


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 
            420                 425                 430         


Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 
        435                 440                 445             


Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
    450                 455                 460                 


Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 
465                 470                 475                 480 


Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 
                485                 490                 495     


Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 
            500                 505                 510         


Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 
        515                 520                 525             


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 
    530                 535                 540                 


Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala 
545                 550                 555                 560 


Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro 
                565                 570                 575     


His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu 
            580                 585                 590         


Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu 
        595                 600                 605             


Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys 
    610                 615                 620                 


Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu 
625                 630                 635                 640 


Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met 
                645                 650                 655     


Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val 
            660                 665                 670         


Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr 
        675                 680                 685             


Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp 
    690                 695                 700                 


Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His 
705                 710                 715                 720 


Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln 
                725                 730                 735     


Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu 
            740                 745                 750         


Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys 
        755                 760                 765             


Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys 
    770                 775                 780                 


Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Ser Gly 
785                 790                 795                 800 


Gly Gly Ser Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly 
                805                 810                 815     


Ser Ser Ser Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala 
            820                 825                 830         


Lys Ala Phe Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val 
        835                 840                 845             


Ser Val Leu Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn 
    850                 855                 860                 


Val Val Pro Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln 
865                 870                 875                 880 


Arg Glu Gly Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val 
                885                 890                 895     


Arg Tyr Leu Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys 
            900                 905                 910         


Ala Val Val Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala 
        915                 920                 925             


Ala Ala Asp Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly 
    930                 935                 940                 


Ile Gly Asp Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro 
945                 950                 955                 960 


Ala Gly Asp Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro 
                965                 970                 975     


Thr Met Val Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly 
            980                 985                 990         


Phe Val Arg Ile 
        995     


<210> 66
<211> 794
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Gln Val Glu Val Val Thr Gln Asp Glu Arg Lys Ala Leu His Thr Thr 
1               5                   10                  15      


Ala Ser Leu Arg Cys Ser Leu Lys Thr Ser Gln Glu Pro Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Tyr 
        35                  40                  45              


Ser Lys Thr His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Arg Ile 
    50                  55                  60                  


Asn Val Thr Glu Leu Gly Leu Trp Asn Ser Ser Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Thr Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Ser Gln Lys Val Ser Gly Thr Ala Cys Leu Thr Leu Tyr Val Gln 
            100                 105                 110         


Pro Ile Val His Leu His Tyr Asn Tyr Phe Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Ala Ile Ser Trp Lys Gly 
    130                 135                 140                 


Thr Gly Thr Gly Ile Glu Asn Ser Thr Glu Ser His Phe His Ser Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu Arg Val Lys Asp Pro Lys Thr 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu Tyr Leu Gly Asn Val 
            180                 185                 190         


Ile Asp Tyr Lys Gln Ser Leu Asp Lys Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu 
    210                 215                 220                 


Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr 
225                 230                 235                 240 


Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val 
                245                 250                 255     


Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys 
            260                 265                 270         


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro 
        275                 280                 285             


Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln 
    290                 295                 300                 


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
305                 310                 315                 320 


Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser 
                325                 330                 335     


Phe Lys Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val 
            340                 345                 350         


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala 
        355                 360                 365             


Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys 
    370                 375                 380                 


Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu 
385                 390                 395                 400 


Val Ser Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe 
                405                 410                 415     


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr 
            420                 425                 430         


Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu 
        435                 440                 445             


Thr Lys Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
    450                 455                 460                 


Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr 
465                 470                 475                 480 


Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys 
                485                 490                 495     


Ala His Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu 
            500                 505                 510         


Pro Ala Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn 
        515                 520                 525             


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr 
    530                 535                 540                 


Ser Arg Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala 
545                 550                 555                 560 


Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro 
                565                 570                 575     


Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu 
            580                 585                 590         


Glu Pro Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu 
        595                 600                 605             


Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys 
    610                 615                 620                 


Ala Pro Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu 
625                 630                 635                 640 


Gly Arg Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu 
                645                 650                 655     


Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu 
            660                 665                 670         


Leu His Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser 
        675                 680                 685             


Gly Ser Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp 
    690                 695                 700                 


Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His 
705                 710                 715                 720 


Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln 
                725                 730                 735     


Thr Ala Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu 
            740                 745                 750         


Gln Leu Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys 
        755                 760                 765             


Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn 
    770                 775                 780                 


Leu Val Thr Arg Cys Lys Asp Ala Leu Ala 
785                 790                 


<210> 67
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 67
His His His His His His 
1               5       


<210> 68
<211> 11
<212> PRT
<213> Homo sapiens

<400> 68
Ser Tyr Ile Arg Ile Ala Asp Thr Asn Ile Thr 
1               5                   10      


<210> 69
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Cy7 label

<400> 69
Leu Arg Glu Leu His Leu Asn Asn Asn Cys 
1               5                   10  



